ASB18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)5.64063037
2behavioral response to nicotine (GO:0035095)5.47994228
3neutrophil activation involved in immune response (GO:0002283)4.53652201
4hydrogen peroxide biosynthetic process (GO:0050665)4.48240823
5regulation of skeletal muscle contraction (GO:0014819)4.42561586
6detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.28663191
7myofibril assembly (GO:0030239)4.22221905
8heart process (GO:0003015)4.05838454
9heart contraction (GO:0060047)4.05838454
10response to pheromone (GO:0019236)3.99112997
11DNA deamination (GO:0045006)3.98245617
12sarcoplasmic reticulum calcium ion transport (GO:0070296)3.95113178
13reactive oxygen species biosynthetic process (GO:1903409)3.93003536
14regulation of relaxation of muscle (GO:1901077)3.90271784
15response to peptidoglycan (GO:0032494)3.88355363
16L-fucose catabolic process (GO:0042355)3.85418807
17fucose catabolic process (GO:0019317)3.85418807
18L-fucose metabolic process (GO:0042354)3.85418807
19sarcomere organization (GO:0045214)3.84774600
20regulation of sarcomere organization (GO:0060297)3.75915683
21muscle filament sliding (GO:0030049)3.72082537
22actin-myosin filament sliding (GO:0033275)3.72082537
23regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.68520688
24cellular ketone body metabolic process (GO:0046950)3.68449732
25production of molecular mediator involved in inflammatory response (GO:0002532)3.64245140
26indolalkylamine metabolic process (GO:0006586)3.61778637
27indole-containing compound catabolic process (GO:0042436)3.61196302
28indolalkylamine catabolic process (GO:0046218)3.61196302
29tryptophan catabolic process (GO:0006569)3.61196302
30cardiac myofibril assembly (GO:0055003)3.54151536
31cellular response to zinc ion (GO:0071294)3.52945245
32detection of other organism (GO:0098543)3.51785915
33kynurenine metabolic process (GO:0070189)3.51362221
34NADH dehydrogenase complex assembly (GO:0010257)3.50275828
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.50275828
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.50275828
37positive regulation of cellular amide metabolic process (GO:0034250)3.49992286
38ketone body metabolic process (GO:1902224)3.41055516
39actin-mediated cell contraction (GO:0070252)3.39247504
40protein complex biogenesis (GO:0070271)3.38874712
41detection of light stimulus involved in sensory perception (GO:0050962)3.38856346
42detection of light stimulus involved in visual perception (GO:0050908)3.38856346
43response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.38310043
44detection of bacterium (GO:0016045)3.36135247
45regulation of cell communication by electrical coupling (GO:0010649)3.32517331
46eosinophil chemotaxis (GO:0048245)3.30947349
47skeletal muscle contraction (GO:0003009)3.30406667
48positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.30273529
49positive regulation by symbiont of host defense response (GO:0052509)3.29400504
50modulation by symbiont of host defense response (GO:0052031)3.29400504
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.29400504
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.29400504
53positive regulation by organism of defense response of other organism involved in symbiotic interact3.29400504
54modulation by symbiont of host immune response (GO:0052553)3.29400504
55piRNA metabolic process (GO:0034587)3.28402154
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.27722878
57neutrophil activation (GO:0042119)3.27182468
58tryptophan metabolic process (GO:0006568)3.25708829
59negative regulation of mast cell activation (GO:0033004)3.25223603
60granulocyte activation (GO:0036230)3.22680961
61protein polyglutamylation (GO:0018095)3.21872579
62regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.20118092
63water-soluble vitamin biosynthetic process (GO:0042364)3.19792098
64regulation of actin filament-based movement (GO:1903115)3.17701559
65mitochondrial respiratory chain complex assembly (GO:0033108)3.16198457
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.15556318
67daunorubicin metabolic process (GO:0044597)3.14267923
68polyketide metabolic process (GO:0030638)3.14267923
69doxorubicin metabolic process (GO:0044598)3.14267923
70phosphatidylinositol acyl-chain remodeling (GO:0036149)3.13059684
71superoxide metabolic process (GO:0006801)3.12433849
72respiratory chain complex IV assembly (GO:0008535)3.11063576
73cornea development in camera-type eye (GO:0061303)3.10749266
74neuronal action potential (GO:0019228)3.10573233
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.09018061
76positive regulation of prostaglandin secretion (GO:0032308)3.08753708
77skeletal muscle adaptation (GO:0043501)3.08226141
78reflex (GO:0060004)3.07826339
79respiratory burst (GO:0045730)3.07324033
80negative regulation of cAMP-mediated signaling (GO:0043951)3.06162280
81regulation of action potential (GO:0098900)3.04982200
82preassembly of GPI anchor in ER membrane (GO:0016254)3.03030496
83detection of calcium ion (GO:0005513)3.02646417
84pyrimidine ribonucleoside catabolic process (GO:0046133)3.02270454
85indole-containing compound metabolic process (GO:0042430)3.01930197
86cellular response to ATP (GO:0071318)3.01317225
87negative regulation of telomere maintenance (GO:0032205)3.00303734
88platelet dense granule organization (GO:0060155)2.99089894
89response to host immune response (GO:0052572)2.98810494
90response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98810494
91eosinophil migration (GO:0072677)2.98244951
92protein-cofactor linkage (GO:0018065)2.97059505
93primary amino compound metabolic process (GO:1901160)2.96074752
94synaptic transmission, cholinergic (GO:0007271)2.94407341
95cellular response to exogenous dsRNA (GO:0071360)2.94074949
96positive regulation of fatty acid transport (GO:2000193)2.92737914
97regulation of activation of Janus kinase activity (GO:0010533)2.91798920
98epithelial cilium movement (GO:0003351)2.91352134
99muscle hypertrophy (GO:0014896)2.88937528
100positive regulation of cAMP-mediated signaling (GO:0043950)2.88750699
101mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87974335
102kidney morphogenesis (GO:0060993)2.87714576
103cilium or flagellum-dependent cell motility (GO:0001539)2.87026069
104axoneme assembly (GO:0035082)2.86352352
105ubiquinone biosynthetic process (GO:0006744)2.84295930
106replication fork processing (GO:0031297)2.83329054
107detection of mechanical stimulus involved in sensory perception (GO:0050974)2.82471369
108muscle atrophy (GO:0014889)2.82257575
109bundle of His cell to Purkinje myocyte communication (GO:0086069)2.81166268
110nonmotile primary cilium assembly (GO:0035058)2.80917507
111amino acid salvage (GO:0043102)2.80282546
112L-methionine salvage (GO:0071267)2.80282546
113L-methionine biosynthetic process (GO:0071265)2.80282546
114photoreceptor cell maintenance (GO:0045494)2.79902367
115auditory receptor cell stereocilium organization (GO:0060088)2.79208836
116detection of molecule of bacterial origin (GO:0032490)2.78913092
117positive regulation of mast cell activation involved in immune response (GO:0033008)2.77413001
118positive regulation of mast cell degranulation (GO:0043306)2.77413001
119protein K11-linked deubiquitination (GO:0035871)2.76624485
120regulation of striated muscle contraction (GO:0006942)2.76334372
121behavioral response to ethanol (GO:0048149)2.76064922
122positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.75101183
123regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74042133
124regulation of sequestering of triglyceride (GO:0010889)2.73949685
125adenosine metabolic process (GO:0046085)2.73565224
126positive regulation of antigen processing and presentation (GO:0002579)2.73457378
127regulation of dendritic cell antigen processing and presentation (GO:0002604)2.73152893
128striated muscle contraction (GO:0006941)2.72721459
129DNA methylation involved in gamete generation (GO:0043046)2.70018797
130detection of external biotic stimulus (GO:0098581)2.67683847
131positive regulation of monocyte chemotaxis (GO:0090026)2.67572971
132cytidine deamination (GO:0009972)2.66810647
133cytidine metabolic process (GO:0046087)2.66810647
134cytidine catabolic process (GO:0006216)2.66810647
135RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66661837
136regulation of hexokinase activity (GO:1903299)2.66215126
137regulation of glucokinase activity (GO:0033131)2.66215126
138striated muscle atrophy (GO:0014891)2.65508459
139reciprocal meiotic recombination (GO:0007131)2.65314327
140reciprocal DNA recombination (GO:0035825)2.65314327
141cilium morphogenesis (GO:0060271)2.65116179
142positive regulation of interleukin-1 beta secretion (GO:0050718)2.64854301
143retinal cone cell development (GO:0046549)2.63305171
144sulfation (GO:0051923)2.62702653
145ubiquinone metabolic process (GO:0006743)2.62192408
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.60234900
147mannosylation (GO:0097502)2.60108083
148serotonin metabolic process (GO:0042428)2.59933793
149cytochrome complex assembly (GO:0017004)2.59846005
150positive regulation of icosanoid secretion (GO:0032305)2.58540547
151rhodopsin mediated signaling pathway (GO:0016056)2.58466014
152muscle adaptation (GO:0043500)2.58426922
153proline transport (GO:0015824)2.58418504
154rRNA catabolic process (GO:0016075)2.58173770
155relaxation of cardiac muscle (GO:0055119)2.57683937
156T-helper 1 type immune response (GO:0042088)2.57533721
157signal peptide processing (GO:0006465)2.57124912
158adaptation of signaling pathway (GO:0023058)2.57072603
159cardiac muscle hypertrophy (GO:0003300)2.56854131
160cardiac muscle contraction (GO:0060048)2.55867188
161photoreceptor cell development (GO:0042461)2.55191146
162gamma-aminobutyric acid transport (GO:0015812)2.54969827
163S-adenosylmethionine metabolic process (GO:0046500)2.54896517
164hindbrain development (GO:0030902)2.53436046
165regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52228366
166recombinational repair (GO:0000725)2.51913044
167cardiac muscle tissue morphogenesis (GO:0055008)2.51541397
168negative regulation of viral genome replication (GO:0045071)2.51140255
169tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.50990268
170RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.50990268
171striated muscle hypertrophy (GO:0014897)2.50855914
172regulation of cilium movement (GO:0003352)2.50258549
173multicellular organism reproduction (GO:0032504)2.49861128
174neuronal action potential propagation (GO:0019227)2.49414114
175response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.48994810
176response to host (GO:0075136)2.48994810
177response to host defenses (GO:0052200)2.48994810
178double-strand break repair via homologous recombination (GO:0000724)2.48801579
179regulation of nuclear cell cycle DNA replication (GO:0033262)2.47610908
180cilium organization (GO:0044782)2.47481172
181cAMP catabolic process (GO:0006198)2.46319378
182positive regulation of heat generation (GO:0031652)2.45424525
183adult heart development (GO:0007512)2.45332953
184phosphatidylserine acyl-chain remodeling (GO:0036150)2.45147433
185actomyosin structure organization (GO:0031032)2.44998606
186regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.44483359
187cilium movement (GO:0003341)2.43881429
188positive regulation of lymphocyte migration (GO:2000403)2.43075689
189regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.42687072
190positive regulation of interleukin-1 secretion (GO:0050716)2.40756168
191neural tube formation (GO:0001841)2.40714219
192natural killer cell activation involved in immune response (GO:0002323)2.39702616
193methionine biosynthetic process (GO:0009086)2.39466509
194maturation of 5.8S rRNA (GO:0000460)2.38890700
195inner ear receptor stereocilium organization (GO:0060122)2.38854404
196G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.38046623
197ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.37977502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.14228618
2ZNF274_21170338_ChIP-Seq_K562_Hela3.98489370
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.14802799
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04018687
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.92919408
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.83877854
7GBX2_23144817_ChIP-Seq_PC3_Human2.83600169
8* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.69775926
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68935440
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.51579069
11* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.25005418
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.19058644
13FUS_26573619_Chip-Seq_HEK293_Human2.16772984
14* NFE2_27457419_Chip-Seq_LIVER_Mouse2.14935308
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12507856
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12398269
17EZH2_22144423_ChIP-Seq_EOC_Human2.09846257
18EWS_26573619_Chip-Seq_HEK293_Human2.08533030
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08501777
20* PCGF2_27294783_Chip-Seq_NPCs_Mouse2.07830876
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03079363
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02536674
23* EZH2_27294783_Chip-Seq_NPCs_Mouse1.99758391
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.96888149
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96753945
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.89705574
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88125773
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.80259459
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79199428
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77783421
31* STAT3_18555785_Chip-Seq_ESCs_Mouse1.76591909
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72778860
33* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.69369628
34* P53_22387025_ChIP-Seq_ESCs_Mouse1.68952829
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65917133
36* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.64845011
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63823590
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.62736932
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61839217
40* E2F1_18555785_Chip-Seq_ESCs_Mouse1.59173527
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59123506
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57603544
43TP53_22573176_ChIP-Seq_HFKS_Human1.56628432
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55569288
45BCAT_22108803_ChIP-Seq_LS180_Human1.55194428
46* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.54469618
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53025615
48IRF1_19129219_ChIP-ChIP_H3396_Human1.52350203
49* NMYC_18555785_Chip-Seq_ESCs_Mouse1.52310846
50* NANOG_18555785_Chip-Seq_ESCs_Mouse1.51496784
51* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.50818629
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50430972
53CBP_20019798_ChIP-Seq_JUKART_Human1.50430972
54* STAT3_23295773_ChIP-Seq_U87_Human1.48986215
55* CRX_20693478_ChIP-Seq_RETINA_Mouse1.48643363
56* SOX2_18555785_Chip-Seq_ESCs_Mouse1.45421817
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45162887
58* PU1_27457419_Chip-Seq_LIVER_Mouse1.44784511
59* ZFX_18555785_Chip-Seq_ESCs_Mouse1.44391969
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.43928412
61AR_25329375_ChIP-Seq_VCAP_Human1.43277775
62* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43158984
63VDR_22108803_ChIP-Seq_LS180_Human1.42616717
64* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.42081225
65MYC_18940864_ChIP-ChIP_HL60_Human1.42080394
66* P300_18555785_Chip-Seq_ESCs_Mouse1.41593827
67* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.41501772
68* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38240502
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.37657655
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37657655
71* CMYC_18555785_Chip-Seq_ESCs_Mouse1.37633333
72* OCT4_18555785_Chip-Seq_ESCs_Mouse1.37102683
73* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.35997652
74SOX2_19829295_ChIP-Seq_ESCs_Human1.35680099
75NANOG_19829295_ChIP-Seq_ESCs_Human1.35680099
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35626281
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35453542
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34145674
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.33907353
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.33866767
81* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.33610209
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.33572420
83TCF4_22108803_ChIP-Seq_LS180_Human1.32759045
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27986966
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27700303
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27115177
87* KLF4_18555785_Chip-Seq_ESCs_Mouse1.26443172
88KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26327657
89* CTCF_18555785_Chip-Seq_ESCs_Mouse1.22942602
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22887957
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22591666
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21672524
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.20192859
94ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20155932
95NCOR_22424771_ChIP-Seq_293T_Human1.19962139
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19801421
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19801421
98ER_23166858_ChIP-Seq_MCF-7_Human1.19440604
99P300_19829295_ChIP-Seq_ESCs_Human1.19302699
100* RUNX2_22187159_ChIP-Seq_PCA_Human1.19074638
101REST_21632747_ChIP-Seq_MESCs_Mouse1.18714689
102IGF1R_20145208_ChIP-Seq_DFB_Human1.18203073
103GATA3_21878914_ChIP-Seq_MCF-7_Human1.17890459
104AR_20517297_ChIP-Seq_VCAP_Human1.17609797
105PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16810683
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15942765
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14785533
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14517602
109HOXB7_26014856_ChIP-Seq_BT474_Human1.14472900
110GATA2_21666600_ChIP-Seq_HMVEC_Human1.14452221
111RNF2_27304074_Chip-Seq_NSC_Mouse1.14288873
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.13784718
113* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10540012
114KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10476666
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10370305
116NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10370305
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10266014
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.09793012
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09036702
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.08387786
121EST1_17652178_ChIP-ChIP_JURKAT_Human1.06570500
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06278726
123SMAD4_21799915_ChIP-Seq_A2780_Human1.06022306
124FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05193279
125CBX2_27304074_Chip-Seq_ESCs_Mouse1.04750547
126ELK1_19687146_ChIP-ChIP_HELA_Human1.03897560
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02089928
128CDX2_22108803_ChIP-Seq_LS180_Human1.02025831
129TP53_18474530_ChIP-ChIP_U2OS_Human1.01591963
130TP53_16413492_ChIP-PET_HCT116_Human1.00624466
131STAT1_17558387_ChIP-Seq_HELA_Human0.99244398
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97925097
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97030094
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95816604
135VDR_24787735_ChIP-Seq_THP-1_Human0.95795366
136AR_21572438_ChIP-Seq_LNCaP_Human0.95561827
137* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95365346
138NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95341509
139AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95285072
140LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93368495
141TAF15_26573619_Chip-Seq_HEK293_Human0.91599608
142TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90624673
143SMAD3_21741376_ChIP-Seq_EPCs_Human0.88578850
144PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.88138111
145STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87617723
146CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86732315
147RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86607140
148NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86113711
149KDM2B_26808549_Chip-Seq_REH_Human0.85845260
150FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85765980
151SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85150496
152HTT_18923047_ChIP-ChIP_STHdh_Human0.85035908
153EED_16625203_ChIP-ChIP_MESCs_Mouse0.84810649
154SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.82069530
155TCF4_23295773_ChIP-Seq_U87_Human0.81928656
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81696540
157GF1_26923725_Chip-Seq_HPCs_Mouse0.81580549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.05466744
2MP0002837_dystrophic_cardiac_calcinosis4.62323779
3MP0000749_muscle_degeneration3.19637850
4MP0001968_abnormal_touch/_nociception2.84670999
5MP0004215_abnormal_myocardial_fiber2.82865984
6MP0001188_hyperpigmentation2.76649940
7MP0002148_abnormal_hypersensitivity_rea2.72135000
8MP0008877_abnormal_DNA_methylation2.63401221
9MP0003195_calcinosis2.63163973
10MP0000751_myopathy2.58165734
11MP0005551_abnormal_eye_electrophysiolog2.56310131
12MP0004036_abnormal_muscle_relaxation2.46790810
13MP0004084_abnormal_cardiac_muscle2.42536445
14MP0009785_altered_susceptibility_to2.34266900
15MP0001835_abnormal_antigen_presentation2.31763889
16MP0002277_abnormal_respiratory_mucosa2.19373508
17MP0003724_increased_susceptibility_to2.10718003
18MP0002736_abnormal_nociception_after2.09823443
19MP0003136_yellow_coat_color2.09028652
20MP0003436_decreased_susceptibility_to2.08261450
21MP0005330_cardiomyopathy2.06265746
22MP0004147_increased_porphyrin_level2.02698585
23MP0002972_abnormal_cardiac_muscle2.00773998
24MP0002419_abnormal_innate_immunity2.00629167
25MP0004510_myositis2.00482291
26MP0006072_abnormal_retinal_apoptosis1.98868304
27MP0008872_abnormal_physiological_respon1.96886010
28MP0001501_abnormal_sleep_pattern1.92791565
29MP0005253_abnormal_eye_physiology1.87828717
30MP0002938_white_spotting1.86371526
31MP0009764_decreased_sensitivity_to1.81502001
32MP0009745_abnormal_behavioral_response1.81274901
33MP0002138_abnormal_hepatobiliary_system1.79441514
34MP0003828_pulmonary_edema1.79326634
35MP0005620_abnormal_muscle_contractility1.76453295
36MP0003787_abnormal_imprinting1.75378228
37MP0008260_abnormal_autophagy1.74142240
38MP0009046_muscle_twitch1.73421741
39MP0004484_altered_response_of1.71240836
40MP0002106_abnormal_muscle_physiology1.70407306
41MP0008875_abnormal_xenobiotic_pharmacok1.70005440
42MP0004142_abnormal_muscle_tone1.69476831
43MP0005025_abnormal_response_to1.69180194
44MP0005670_abnormal_white_adipose1.67930464
45MP0006082_CNS_inflammation1.67046648
46MP0004145_abnormal_muscle_electrophysio1.66051284
47MP0004782_abnormal_surfactant_physiolog1.64316747
48MP0005000_abnormal_immune_tolerance1.63497512
49MP0008775_abnormal_heart_ventricle1.62928776
50MP0009697_abnormal_copulation1.62375904
51MP0003137_abnormal_impulse_conducting1.61073249
52MP0005451_abnormal_body_composition1.59046809
53MP0006292_abnormal_olfactory_placode1.58640718
54MP0000343_altered_response_to1.57889384
55MP0000427_abnormal_hair_cycle1.57246771
56MP0000569_abnormal_digit_pigmentation1.55785675
57MP0010386_abnormal_urinary_bladder1.54394373
58MP0002638_abnormal_pupillary_reflex1.53105867
59MP0002272_abnormal_nervous_system1.52604800
60MP0002653_abnormal_ependyma_morphology1.49991916
61MP0005369_muscle_phenotype1.46981623
62MP0005084_abnormal_gallbladder_morpholo1.46801982
63MP0004885_abnormal_endolymph1.45372293
64MP0008058_abnormal_DNA_repair1.40431115
65MP0005389_reproductive_system_phenotype1.40038015
66MP0000631_abnormal_neuroendocrine_gland1.39669932
67MP0005387_immune_system_phenotype1.39585123
68MP0001790_abnormal_immune_system1.39585123
69MP0005385_cardiovascular_system_phenoty1.39276217
70MP0001544_abnormal_cardiovascular_syste1.39276217
71MP0001486_abnormal_startle_reflex1.38279800
72MP0004130_abnormal_muscle_cell1.38130003
73MP0006276_abnormal_autonomic_nervous1.37646567
74MP0005171_absent_coat_pigmentation1.37537635
75MP0000566_synostosis1.36317989
76MP0002160_abnormal_reproductive_system1.35951069
77MP0004133_heterotaxia1.34594106
78MP0004043_abnormal_pH_regulation1.31122883
79MP0003880_abnormal_central_pattern1.29126372
80MP0002332_abnormal_exercise_endurance1.27050753
81MP0001485_abnormal_pinna_reflex1.26793566
82MP0002735_abnormal_chemical_nociception1.26088085
83MP0004087_abnormal_muscle_fiber1.24691879
84MP0008004_abnormal_stomach_pH1.24362877
85MP0000750_abnormal_muscle_regeneration1.20954234
86MP0002557_abnormal_social/conspecific_i1.20880271
87MP0002693_abnormal_pancreas_physiology1.20637595
88MP0003011_delayed_dark_adaptation1.19472759
89MP0002572_abnormal_emotion/affect_behav1.18705884
90MP0006036_abnormal_mitochondrial_physio1.18492902
91MP0002452_abnormal_antigen_presenting1.17694887
92MP0001919_abnormal_reproductive_system1.16348787
93MP0001984_abnormal_olfaction1.14951973
94MP0002127_abnormal_cardiovascular_syste1.14757730
95MP0002064_seizures1.13974490
96MP0004924_abnormal_behavior1.13472715
97MP0005386_behavior/neurological_phenoty1.13472715
98MP0002733_abnormal_thermal_nociception1.13126453
99MP0002067_abnormal_sensory_capabilities1.12373482
100MP0005645_abnormal_hypothalamus_physiol1.07905246
101MP0002723_abnormal_immune_serum1.07136607
102MP0001970_abnormal_pain_threshold1.06101014
103MP0002102_abnormal_ear_morphology1.05690009
104MP0002928_abnormal_bile_duct1.05129465
105MP0003283_abnormal_digestive_organ1.02155046
106MP0005195_abnormal_posterior_eye1.01687228
107MP0005671_abnormal_response_to1.01299531
108MP0000015_abnormal_ear_pigmentation1.01070804
109MP0002095_abnormal_skin_pigmentation0.97997287
110MP0002132_abnormal_respiratory_system0.97931284
111MP0001845_abnormal_inflammatory_respons0.97827666
112MP0001533_abnormal_skeleton_physiology0.95993865
113MP0003718_maternal_effect0.95841753
114MP0002909_abnormal_adrenal_gland0.95839306
115MP0005646_abnormal_pituitary_gland0.95794407
116MP0002876_abnormal_thyroid_physiology0.95735692
117MP0001853_heart_inflammation0.94934250
118MP0000759_abnormal_skeletal_muscle0.94620444
119MP0005332_abnormal_amino_acid0.94473562
120MP0005165_increased_susceptibility_to0.93596433
121MP0005167_abnormal_blood-brain_barrier0.93405059
122MP0008469_abnormal_protein_level0.93007478
123MP0001800_abnormal_humoral_immune0.92557252
124MP0010630_abnormal_cardiac_muscle0.92443328
125MP0002998_abnormal_bone_remodeling0.92399188
126MP0000678_abnormal_parathyroid_gland0.92197686
127MP0001905_abnormal_dopamine_level0.91484823
128MP0003186_abnormal_redox_activity0.91124716
129MP0001819_abnormal_immune_cell0.88621753
130MP0005075_abnormal_melanosome_morpholog0.88599849
131MP0002734_abnormal_mechanical_nocicepti0.88030996
132MP0005257_abnormal_intraocular_pressure0.86523536
133MP0002420_abnormal_adaptive_immunity0.86112030
134MP0002752_abnormal_somatic_nervous0.85804902
135MP0005085_abnormal_gallbladder_physiolo0.85384351
136MP0001324_abnormal_eye_pigmentation0.84571537
137MP0000230_abnormal_systemic_arterial0.83723873
138MP0004085_abnormal_heartbeat0.83474567
139MP0004742_abnormal_vestibular_system0.83299854
140MP0003252_abnormal_bile_duct0.83162858
141MP0010329_abnormal_lipoprotein_level0.82664055
142MP0003698_abnormal_male_reproductive0.82586162
143MP0000026_abnormal_inner_ear0.81975615
144MP0002163_abnormal_gland_morphology0.79689736
145MP0001529_abnormal_vocalization0.79682190
146MP0008995_early_reproductive_senescence0.79511328
147MP0005410_abnormal_fertilization0.79081347
148MP0010155_abnormal_intestine_physiology0.78097582
149MP0002063_abnormal_learning/memory/cond0.77698561
150MP0001963_abnormal_hearing_physiology0.77462024
151MP0005058_abnormal_lysosome_morphology0.77344481
152MP0002269_muscular_atrophy0.77151442
153MP0000579_abnormal_nail_morphology0.76769414
154MP0002229_neurodegeneration0.76684299
155MP0000372_irregular_coat_pigmentation0.76602931
156MP0000538_abnormal_urinary_bladder0.76547912
157MP0001929_abnormal_gametogenesis0.76310422
158MP0002184_abnormal_innervation0.75138887
159MP0004019_abnormal_vitamin_homeostasis0.74773029
160MP0001986_abnormal_taste_sensitivity0.74472356
161MP0006138_congestive_heart_failure0.74383676
162MP0005379_endocrine/exocrine_gland_phen0.70214807
163MP0005409_darkened_coat_color0.68867014
164MP0003950_abnormal_plasma_membrane0.67886304
165MP0002078_abnormal_glucose_homeostasis0.66139080
166MP0001879_abnormal_lymphatic_vessel0.64686065
167MP0010368_abnormal_lymphatic_system0.64474917
168MP0005174_abnormal_tail_pigmentation0.63940625
169MP0005535_abnormal_body_temperature0.63709203
170MP0002234_abnormal_pharynx_morphology0.60946598
171MP0001764_abnormal_homeostasis0.60725926

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.48830704
2Calf muscle hypertrophy (HP:0008981)4.43136861
3Muscle hypertrophy of the lower extremities (HP:0008968)4.25915165
4Pancreatic fibrosis (HP:0100732)4.15772114
5True hermaphroditism (HP:0010459)4.10336563
6Ventricular tachycardia (HP:0004756)3.91942426
7Atrial fibrillation (HP:0005110)3.91260773
8Sudden death (HP:0001699)3.90318411
9Abnormality of midbrain morphology (HP:0002418)3.88814716
10Molar tooth sign on MRI (HP:0002419)3.88814716
11Eczematoid dermatitis (HP:0000976)3.85821961
12Type II lissencephaly (HP:0007260)3.79990300
13Congenital stationary night blindness (HP:0007642)3.73969487
14Exercise-induced myalgia (HP:0003738)3.65444617
15Nephronophthisis (HP:0000090)3.58359631
16Recurrent abscess formation (HP:0002722)3.54354732
17Recurrent gram-negative bacterial infections (HP:0005420)3.53765014
18Primary atrial arrhythmia (HP:0001692)3.51093490
19Abnormality of the renal cortex (HP:0011035)3.43459897
20Congenital sensorineural hearing impairment (HP:0008527)3.38513797
21Supraventricular tachycardia (HP:0004755)3.31852626
22Medial flaring of the eyebrow (HP:0010747)3.23142825
23Exercise-induced muscle cramps (HP:0003710)3.22819102
24Abnormality of the calf musculature (HP:0001430)3.22765876
25Recurrent bacterial skin infections (HP:0005406)3.20396639
26Supraventricular arrhythmia (HP:0005115)3.17505445
27Abnormality of the renal medulla (HP:0100957)3.13767894
28Cerebellar dysplasia (HP:0007033)3.07544640
29Abnormality of the left ventricular outflow tract (HP:0011103)3.02701235
30Subaortic stenosis (HP:0001682)3.02701235
31Lipoatrophy (HP:0100578)2.99433689
32Distal lower limb muscle weakness (HP:0009053)2.93018591
33Muscle fiber splitting (HP:0003555)2.92680986
34Syncope (HP:0001279)2.91810894
35Attenuation of retinal blood vessels (HP:0007843)2.87551489
36Prostate neoplasm (HP:0100787)2.87367059
37Abolished electroretinogram (ERG) (HP:0000550)2.86073753
38Dilated cardiomyopathy (HP:0001644)2.84227183
39Hyperventilation (HP:0002883)2.81329124
40Palpitations (HP:0001962)2.77914984
41Tubular atrophy (HP:0000092)2.75401238
42Cystic liver disease (HP:0006706)2.73935936
43Prolonged QT interval (HP:0001657)2.71302700
44Osteomalacia (HP:0002749)2.68569371
45Generalized aminoaciduria (HP:0002909)2.66979789
46Gingivitis (HP:0000230)2.66063503
47Chromosomal breakage induced by crosslinking agents (HP:0003221)2.65904686
48Renal Fanconi syndrome (HP:0001994)2.65683949
49Pendular nystagmus (HP:0012043)2.65256525
50Abnormal drinking behavior (HP:0030082)2.62033807
51Polydipsia (HP:0001959)2.62033807
52Acute necrotizing encephalopathy (HP:0006965)2.60511520
53Increased corneal curvature (HP:0100692)2.57773070
54Keratoconus (HP:0000563)2.57773070
55Chronic hepatic failure (HP:0100626)2.55892098
56Aplasia/Hypoplasia of the fovea (HP:0008060)2.55608371
57Hypoplasia of the fovea (HP:0007750)2.55608371
58Hyperinsulinemic hypoglycemia (HP:0000825)2.54779838
59Hepatic necrosis (HP:0002605)2.52825221
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.52563959
61Hypoglycemic coma (HP:0001325)2.48627294
62Mitochondrial inheritance (HP:0001427)2.48427972
63Abnormal rod and cone electroretinograms (HP:0008323)2.48057872
64Abnormal mitochondria in muscle tissue (HP:0008316)2.47420460
65Sclerocornea (HP:0000647)2.47353018
66Abnormality of macrophages (HP:0004311)2.45581070
67Renal cortical cysts (HP:0000803)2.39340174
68Gait imbalance (HP:0002141)2.38726608
69Increased hepatocellular lipid droplets (HP:0006565)2.38557298
70Asymmetric septal hypertrophy (HP:0001670)2.38179179
71Abnormal EKG (HP:0003115)2.36708602
72Lipid accumulation in hepatocytes (HP:0006561)2.36534215
73Large for gestational age (HP:0001520)2.33875610
74EMG: myopathic abnormalities (HP:0003458)2.32581109
75Congenital primary aphakia (HP:0007707)2.31864322
76Abnormality of the pons (HP:0007361)2.30335749
77Joint hemorrhage (HP:0005261)2.29417468
78Bundle branch block (HP:0011710)2.29060052
79Ventricular arrhythmia (HP:0004308)2.28720776
80Hypoplasia of the pons (HP:0012110)2.28580719
81Type 2 muscle fiber atrophy (HP:0003554)2.27263718
82Gaze-evoked nystagmus (HP:0000640)2.26250065
83Right ventricular cardiomyopathy (HP:0011663)2.26146510
84Heart block (HP:0012722)2.25762236
85Insulin-resistant diabetes mellitus (HP:0000831)2.24793109
86Aplasia/Hypoplasia of the tongue (HP:0010295)2.23848245
87Chromsome breakage (HP:0040012)2.23536797
88Lissencephaly (HP:0001339)2.23446933
89Increased intramyocellular lipid droplets (HP:0012240)2.22924723
90Abnormality of renal resorption (HP:0011038)2.21970144
91Congenital hepatic fibrosis (HP:0002612)2.20480295
92Anencephaly (HP:0002323)2.19614421
93Vacuolated lymphocytes (HP:0001922)2.19226059
94Aplasia/Hypoplasia of the tibia (HP:0005772)2.18726786
95Inability to walk (HP:0002540)2.17467190
96Retrobulbar optic neuritis (HP:0100654)2.17183784
97Optic neuritis (HP:0100653)2.17183784
98Nephrogenic diabetes insipidus (HP:0009806)2.17183741
99Glycosuria (HP:0003076)2.16925264
100Abnormality of urine glucose concentration (HP:0011016)2.16925264
101Myoglobinuria (HP:0002913)2.16520079
102Abnormal atrioventricular conduction (HP:0005150)2.15719853
103Obstructive lung disease (HP:0006536)2.14231839
104Chronic obstructive pulmonary disease (HP:0006510)2.14231839
105Male pseudohermaphroditism (HP:0000037)2.14140704
106Hyperalaninemia (HP:0003348)2.13308377
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13308377
108Abnormality of alanine metabolism (HP:0010916)2.13308377
109Increased muscle lipid content (HP:0009058)2.13219317
110Abnormal biliary tract physiology (HP:0012439)2.12190640
111Bile duct proliferation (HP:0001408)2.12190640
112Progressive macrocephaly (HP:0004481)2.11757689
113Severe muscular hypotonia (HP:0006829)2.11075389
114Furrowed tongue (HP:0000221)2.10475062
115Chorioretinal atrophy (HP:0000533)2.10409954
116Basal ganglia calcification (HP:0002135)2.10321673
117Polyuria (HP:0000103)2.10266964
118Hepatocellular necrosis (HP:0001404)2.09866692
119Protruding tongue (HP:0010808)2.08692736
120Hyperglycinuria (HP:0003108)2.06474952
121Mediastinal lymphadenopathy (HP:0100721)2.06355705
122Left ventricular hypertrophy (HP:0001712)2.05479396
123Acute encephalopathy (HP:0006846)2.05412440
124Muscle fiber inclusion bodies (HP:0100299)2.05320145
125Increased CSF lactate (HP:0002490)2.05093890
126Progressive inability to walk (HP:0002505)2.04920611
127Decreased central vision (HP:0007663)2.03892568
128Absent/shortened dynein arms (HP:0200106)2.02344053
129Dynein arm defect of respiratory motile cilia (HP:0012255)2.02344053
130Hypothermia (HP:0002045)2.00982218
131Nausea (HP:0002018)2.00884532
132Abnormality of DNA repair (HP:0003254)2.00529712
133Symptomatic seizures (HP:0011145)1.99642285
134Methylmalonic acidemia (HP:0002912)1.98734553
135Alveolar cell carcinoma (HP:0006519)1.98099104
136Fair hair (HP:0002286)1.98059303
137Atrioventricular block (HP:0001678)1.97653060
138Hyperkalemia (HP:0002153)1.97315856
139Abnormal respiratory epithelium morphology (HP:0012253)1.97120266
140Abnormal respiratory motile cilium morphology (HP:0005938)1.97120266
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96807736
142Recurrent pneumonia (HP:0006532)1.96735595
143Abnormality of the fovea (HP:0000493)1.96624213
144Congenital, generalized hypertrichosis (HP:0004540)1.96323779
145Ventricular fibrillation (HP:0001663)1.95850498
146Exertional dyspnea (HP:0002875)1.95260249
147Stomatitis (HP:0010280)1.94737081
148Optic nerve hypoplasia (HP:0000609)1.94492872
149Stomach cancer (HP:0012126)1.94299666
150Exercise intolerance (HP:0003546)1.94297067
151Cheilitis (HP:0100825)1.93700118
152Aplasia/Hypoplasia of the uvula (HP:0010293)1.92854246
153Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.92540065
154Broad-based gait (HP:0002136)1.92369408
155Hemiparesis (HP:0001269)1.91938198
156Hypoglycemic seizures (HP:0002173)1.90583367
157Recurrent skin infections (HP:0001581)1.90040910
158Postaxial foot polydactyly (HP:0001830)1.89518998
159Poor coordination (HP:0002370)1.88603453
160Decreased circulating renin level (HP:0003351)1.88565047
161Cerebral edema (HP:0002181)1.88062101
162Ketosis (HP:0001946)1.84783264
163Genital tract atresia (HP:0001827)1.84665056
164Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84243341
165Hyperglycemia (HP:0003074)1.84214698
166Prolonged neonatal jaundice (HP:0006579)1.84131416
167Abnormal protein glycosylation (HP:0012346)1.83735004
168Abnormal glycosylation (HP:0012345)1.83735004
169Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83735004
170Abnormal protein N-linked glycosylation (HP:0012347)1.83735004
171Pachygyria (HP:0001302)1.83546029
172Abnormality of fatty-acid metabolism (HP:0004359)1.83533071
173Orchitis (HP:0100796)1.82504478
174Hyporeflexia of lower limbs (HP:0002600)1.82163938
175Aplasia/Hypoplasia of the spleen (HP:0010451)1.81301580
176Concave nail (HP:0001598)1.81056542
177Ketoacidosis (HP:0001993)1.80975471
1783-Methylglutaconic aciduria (HP:0003535)1.79376404
179Optic disc pallor (HP:0000543)1.78637904
180Methylmalonic aciduria (HP:0012120)1.78130946
181Bony spicule pigmentary retinopathy (HP:0007737)1.76301897
182Vaginal atresia (HP:0000148)1.76019113
183Progressive cerebellar ataxia (HP:0002073)1.73091806
184Clumsiness (HP:0002312)1.72707830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.73734074
2IRAK33.69102041
3MAP4K23.09283534
4MAP3K143.03916879
5OBSCN2.99396555
6IRAK42.66684537
7PINK12.39374555
8TXK2.39151498
9WNK32.31313520
10PBK2.25984864
11ZAK2.25232052
12WNK42.09301017
13TLK12.05921568
14MUSK2.01141981
15ACVR1B1.91363781
16TTN1.85238297
17BMPR21.79265991
18TIE11.73952452
19PHKG21.70855651
20PHKG11.70855651
21EIF2AK21.70030370
22RIPK41.68090648
23BLK1.67321649
24STK391.64739298
25MST1R1.64578724
26CASK1.59651235
27PIK3CG1.51998970
28OXSR11.51188108
29NEK91.48162464
30NME21.46424040
31GRK71.43229572
32TNIK1.43225807
33PNCK1.41490679
34MYLK1.40258140
35IRAK11.38598178
36TEC1.38061311
37MAP3K41.37112152
38AKT31.36501028
39YES11.35913963
40LMTK21.32636018
41CAMKK21.30116539
42VRK11.30052354
43WEE11.25930736
44PIK3CA1.25024060
45GRK11.24467729
46STK241.24321519
47IKBKB1.23202047
48ERBB31.21192739
49BRSK21.19475325
50TBK11.18596747
51MKNK21.17869121
52NLK1.17016923
53IKBKE1.16521559
54VRK21.15783975
55ADRBK11.12615233
56SGK21.11946639
57NUAK11.10802645
58ADRBK21.07879333
59PAK31.07867834
60STK38L1.07159837
61TRPM71.06626809
62STK41.06438041
63TSSK61.05971114
64STK161.02975861
65EIF2AK31.00852979
66EPHA31.00331141
67TGFBR10.98563220
68JAK10.98034237
69PKN10.97396297
70IRAK20.96431851
71PLK20.95551825
72MAP2K70.93254787
73PDK20.93185680
74JAK30.92751281
75DYRK20.92310221
76PTK2B0.91052321
77TRIM280.90949605
78NEK60.90029549
79PRKCG0.88589469
80PRKCE0.86725216
81DAPK20.83604377
82MAPK70.83057629
83MAPK150.82564766
84DMPK0.82256117
85MAPKAPK30.82199328
86MARK10.82095163
87BMPR1B0.80422313
88PLK30.78489853
89NTRK30.77582383
90NME10.76444353
91CHUK0.74283435
92TAOK30.74240368
93MAPK120.71467901
94CAMK2D0.70583360
95MAPKAPK50.69677182
96CSNK1G10.69347674
97MST40.68923663
98PRPF4B0.66107947
99CSNK1G20.62814216
100MKNK10.62652442
101CSNK1G30.62049544
102MAP3K130.61744330
103BCKDK0.61378083
104RPS6KL10.60274752
105RPS6KC10.60274752
106RPS6KA60.58568181
107FGFR20.57345373
108MAP3K50.56764181
109TYK20.56155204
110SYK0.55820001
111SIK30.55073054
112TNK20.54546203
113SGK30.54493733
114STK110.54186293
115CSNK1A1L0.54074331
116KIT0.53206796
117SGK2230.53125823
118SGK4940.53125823
119PRKCD0.52167140
120STK30.51727787
121PRKCQ0.51441327
122RPS6KA50.50260829
123PRKAA20.50183611
124LYN0.50112785
125MAP2K60.50067480
126CAMK10.49026265
127PLK40.48953252
128ABL20.45660880
129PRKAA10.45351005
130CAMK2A0.44708826
131CDK30.44259357
132FRK0.43747948
133PRKG20.42884255
134PRKACA0.40838963
135MAPK130.40823196
136MARK30.40279843
137PRKCI0.38840516
138ERBB40.38408565
139CSNK1A10.38336570
140SGK10.38217113
141MAP2K20.37584867
142ATR0.35857771
143LIMK10.35783934
144ITK0.35283454
145PRKG10.35106887
146FLT30.35017562
147CSNK1D0.33998080
148CDC42BPA0.33612157
149DYRK1A0.33341816
150CAMK40.33290251
151BTK0.33215611
152PRKCA0.32850922
153GRK50.32490693
154PIM20.31770692
155TAF10.31751422

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.76883689
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.72291850
3Oxidative phosphorylation_Homo sapiens_hsa001902.70904416
4Nitrogen metabolism_Homo sapiens_hsa009102.51313004
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.49182922
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40471688
7Selenocompound metabolism_Homo sapiens_hsa004502.36727663
8Graft-versus-host disease_Homo sapiens_hsa053322.29213667
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01900731
10Rheumatoid arthritis_Homo sapiens_hsa053232.00270146
11Homologous recombination_Homo sapiens_hsa034402.00230511
12Cardiac muscle contraction_Homo sapiens_hsa042601.94978973
13RNA polymerase_Homo sapiens_hsa030201.93532476
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92306741
15Parkinsons disease_Homo sapiens_hsa050121.91068515
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88673993
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.88093668
18Leishmaniasis_Homo sapiens_hsa051401.84430438
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.81737270
20Staphylococcus aureus infection_Homo sapiens_hsa051501.79696200
21Alzheimers disease_Homo sapiens_hsa050101.79277153
22Nicotine addiction_Homo sapiens_hsa050331.79195146
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78130465
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.78000878
25Protein export_Homo sapiens_hsa030601.77602354
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77120142
27Allograft rejection_Homo sapiens_hsa053301.75401261
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75095977
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74011381
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69906210
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.69106784
32Legionellosis_Homo sapiens_hsa051341.67817908
33Caffeine metabolism_Homo sapiens_hsa002321.63205582
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.59904497
35Dilated cardiomyopathy_Homo sapiens_hsa054141.59722205
36Basal transcription factors_Homo sapiens_hsa030221.53739405
37Asthma_Homo sapiens_hsa053101.52341328
38beta-Alanine metabolism_Homo sapiens_hsa004101.50496048
39Propanoate metabolism_Homo sapiens_hsa006401.50428211
40Fatty acid degradation_Homo sapiens_hsa000711.50048324
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.48429170
42Type I diabetes mellitus_Homo sapiens_hsa049401.46390036
43One carbon pool by folate_Homo sapiens_hsa006701.43921403
44Olfactory transduction_Homo sapiens_hsa047401.40495894
45Taste transduction_Homo sapiens_hsa047421.39598124
46Huntingtons disease_Homo sapiens_hsa050161.38481443
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32251209
48Regulation of autophagy_Homo sapiens_hsa041401.30250230
49Peroxisome_Homo sapiens_hsa041461.27122487
50Other glycan degradation_Homo sapiens_hsa005111.25885602
51Starch and sucrose metabolism_Homo sapiens_hsa005001.25082818
52Arachidonic acid metabolism_Homo sapiens_hsa005901.24160598
53RNA degradation_Homo sapiens_hsa030181.20965450
54Autoimmune thyroid disease_Homo sapiens_hsa053201.19877131
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19783570
56TNF signaling pathway_Homo sapiens_hsa046681.19710359
57Measles_Homo sapiens_hsa051621.19236965
58Glycosaminoglycan degradation_Homo sapiens_hsa005311.18571237
59Histidine metabolism_Homo sapiens_hsa003401.18448576
60Hematopoietic cell lineage_Homo sapiens_hsa046401.18046238
61Morphine addiction_Homo sapiens_hsa050321.16637896
62Tuberculosis_Homo sapiens_hsa051521.15603415
63Chemical carcinogenesis_Homo sapiens_hsa052041.12685250
64Phagosome_Homo sapiens_hsa041451.11088749
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10998487
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09138629
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08608377
68Phenylalanine metabolism_Homo sapiens_hsa003601.08096566
69Tryptophan metabolism_Homo sapiens_hsa003801.07240614
70Fatty acid elongation_Homo sapiens_hsa000621.06206364
71Primary bile acid biosynthesis_Homo sapiens_hsa001201.05994166
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04314049
73Pertussis_Homo sapiens_hsa051331.03799367
74Malaria_Homo sapiens_hsa051441.03248936
75Non-homologous end-joining_Homo sapiens_hsa034500.99510236
76Osteoclast differentiation_Homo sapiens_hsa043800.97921998
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94543515
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93978337
79Circadian entrainment_Homo sapiens_hsa047130.92291044
80Fat digestion and absorption_Homo sapiens_hsa049750.89812872
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89006729
82Sulfur metabolism_Homo sapiens_hsa009200.88934251
83Arginine and proline metabolism_Homo sapiens_hsa003300.88562400
84Influenza A_Homo sapiens_hsa051640.88519079
85Lysosome_Homo sapiens_hsa041420.87212602
86ABC transporters_Homo sapiens_hsa020100.86658893
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82849379
88Purine metabolism_Homo sapiens_hsa002300.82712990
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.82688264
90Collecting duct acid secretion_Homo sapiens_hsa049660.81147497
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80948511
92Proteasome_Homo sapiens_hsa030500.80756595
93Serotonergic synapse_Homo sapiens_hsa047260.79805714
94GABAergic synapse_Homo sapiens_hsa047270.78823821
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76805894
96Primary immunodeficiency_Homo sapiens_hsa053400.75721316
97Viral myocarditis_Homo sapiens_hsa054160.73485688
98Salivary secretion_Homo sapiens_hsa049700.71892628
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.71619460
100Glutamatergic synapse_Homo sapiens_hsa047240.71544156
101Fatty acid metabolism_Homo sapiens_hsa012120.70178738
102Nucleotide excision repair_Homo sapiens_hsa034200.66524406
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66078892
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65378719
105Herpes simplex infection_Homo sapiens_hsa051680.65097127
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63412392
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61871501
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61631220
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60156251
110Linoleic acid metabolism_Homo sapiens_hsa005910.60000968
111Sphingolipid metabolism_Homo sapiens_hsa006000.59525217
112Complement and coagulation cascades_Homo sapiens_hsa046100.59041010
113African trypanosomiasis_Homo sapiens_hsa051430.58367239
114Calcium signaling pathway_Homo sapiens_hsa040200.58204889
115Salmonella infection_Homo sapiens_hsa051320.57882186
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57615193
117Glycerolipid metabolism_Homo sapiens_hsa005610.57096232
118Tyrosine metabolism_Homo sapiens_hsa003500.56062388
119Sulfur relay system_Homo sapiens_hsa041220.55391493
120Vitamin digestion and absorption_Homo sapiens_hsa049770.54009312
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.53312392
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52642127
123Galactose metabolism_Homo sapiens_hsa000520.52024120
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51396574
125Retinol metabolism_Homo sapiens_hsa008300.50898836
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50755251
127Pyrimidine metabolism_Homo sapiens_hsa002400.47283249
128Fanconi anemia pathway_Homo sapiens_hsa034600.46850080
129Insulin secretion_Homo sapiens_hsa049110.46640899
130Metabolic pathways_Homo sapiens_hsa011000.45090794
131Chemokine signaling pathway_Homo sapiens_hsa040620.44522866
132Circadian rhythm_Homo sapiens_hsa047100.44422596
133Type II diabetes mellitus_Homo sapiens_hsa049300.42547946
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42065252
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41614785
136Dopaminergic synapse_Homo sapiens_hsa047280.39423226
137Ovarian steroidogenesis_Homo sapiens_hsa049130.38674940
138Butanoate metabolism_Homo sapiens_hsa006500.37826875
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36984585
140PPAR signaling pathway_Homo sapiens_hsa033200.36336207
141Cocaine addiction_Homo sapiens_hsa050300.34828987
142Amphetamine addiction_Homo sapiens_hsa050310.34307264
143Ether lipid metabolism_Homo sapiens_hsa005650.33634146
144Mineral absorption_Homo sapiens_hsa049780.33395730
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.33329186
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.32905525

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