ASAH2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)3.63010362
2pyrimidine nucleobase catabolic process (GO:0006208)3.07161807
3nucleobase catabolic process (GO:0046113)2.87094016
4DNA replication-dependent nucleosome assembly (GO:0006335)2.79754421
5DNA replication-dependent nucleosome organization (GO:0034723)2.79754421
6cullin deneddylation (GO:0010388)2.78399185
7replication fork processing (GO:0031297)2.76637567
8synapsis (GO:0007129)2.74709521
9proteasome assembly (GO:0043248)2.74258758
10respiratory chain complex IV assembly (GO:0008535)2.72771384
11peptidyl-histidine modification (GO:0018202)2.70043275
12regulation of hexokinase activity (GO:1903299)2.69533540
13regulation of glucokinase activity (GO:0033131)2.69533540
14behavioral response to nicotine (GO:0035095)2.64013876
15intraciliary transport (GO:0042073)2.63728333
16water-soluble vitamin biosynthetic process (GO:0042364)2.62180664
17protein K11-linked deubiquitination (GO:0035871)2.57563638
18protein deneddylation (GO:0000338)2.57290224
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.56078536
20regulation of mitotic spindle checkpoint (GO:1903504)2.56078536
21resolution of meiotic recombination intermediates (GO:0000712)2.54965336
22protein K6-linked ubiquitination (GO:0085020)2.53278986
23ubiquinone metabolic process (GO:0006743)2.52830020
24somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51909814
25somatic hypermutation of immunoglobulin genes (GO:0016446)2.51909814
26anterograde synaptic vesicle transport (GO:0048490)2.50273462
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47876882
28protein complex biogenesis (GO:0070271)2.45729434
29organelle disassembly (GO:1903008)2.45397949
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.44050531
31mitochondrial respiratory chain complex assembly (GO:0033108)2.42649358
32RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.41984251
33nonmotile primary cilium assembly (GO:0035058)2.41486626
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.39784630
35negative regulation of DNA recombination (GO:0045910)2.38601572
36maturation of 5.8S rRNA (GO:0000460)2.37458429
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.34664013
38mitochondrial respiratory chain complex I assembly (GO:0032981)2.34664013
39NADH dehydrogenase complex assembly (GO:0010257)2.34664013
40pseudouridine synthesis (GO:0001522)2.34348104
41biotin metabolic process (GO:0006768)2.30828323
42dopamine transport (GO:0015872)2.27625738
43branched-chain amino acid catabolic process (GO:0009083)2.27086108
44amino acid activation (GO:0043038)2.23775601
45tRNA aminoacylation (GO:0043039)2.23775601
46L-methionine salvage (GO:0071267)2.23477940
47L-methionine biosynthetic process (GO:0071265)2.23477940
48amino acid salvage (GO:0043102)2.23477940
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.23056522
50lactate metabolic process (GO:0006089)2.22766667
51ribonucleoprotein complex disassembly (GO:0032988)2.22537231
52tRNA aminoacylation for protein translation (GO:0006418)2.22477324
53regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.22345908
54regulation of helicase activity (GO:0051095)2.21764463
55nuclear pore complex assembly (GO:0051292)2.21530581
56ribosome assembly (GO:0042255)2.20883423
57nuclear pore organization (GO:0006999)2.20251897
58intestinal epithelial cell development (GO:0060576)2.19888796
59negative regulation of transcription regulatory region DNA binding (GO:2000678)2.19351570
60DNA damage response, detection of DNA damage (GO:0042769)2.18417837
61detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.16598076
62single strand break repair (GO:0000012)2.14486277
63response to pheromone (GO:0019236)2.14332420
64cytochrome complex assembly (GO:0017004)2.13629353
65aspartate family amino acid biosynthetic process (GO:0009067)2.13269012
66oxidative demethylation (GO:0070989)2.12292110
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.11579273
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.11579273
69maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.10945133
70methionine biosynthetic process (GO:0009086)2.10149801
71regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.09136626
72reciprocal DNA recombination (GO:0035825)2.08318070
73reciprocal meiotic recombination (GO:0007131)2.08318070
74metaphase plate congression (GO:0051310)2.07459982
75chromatin remodeling at centromere (GO:0031055)2.07166968
76somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.05908270
77isotype switching (GO:0045190)2.05908270
78somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.05908270
79tRNA metabolic process (GO:0006399)2.05699897
80olfactory bulb development (GO:0021772)2.05409756
81regulation of acyl-CoA biosynthetic process (GO:0050812)2.05208126
82prenylation (GO:0097354)2.04205108
83protein prenylation (GO:0018342)2.04205108
84retinal ganglion cell axon guidance (GO:0031290)2.03541475
85behavioral response to ethanol (GO:0048149)2.03464867
86isoprenoid biosynthetic process (GO:0008299)2.02912000
87neural tube formation (GO:0001841)2.02806461
88anterograde axon cargo transport (GO:0008089)2.02552232
89piRNA metabolic process (GO:0034587)2.02089040
90histone H2A acetylation (GO:0043968)2.00421179
91platelet dense granule organization (GO:0060155)2.00094743
92DNA integration (GO:0015074)1.99645288
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)1.99486407
94righting reflex (GO:0060013)1.99367089
95mitochondrial RNA metabolic process (GO:0000959)1.99325515
96presynaptic membrane assembly (GO:0097105)1.98375433
97microtubule anchoring (GO:0034453)1.98344184
98cellular ketone body metabolic process (GO:0046950)1.97896797
99negative regulation of DNA-dependent DNA replication (GO:2000104)1.97348903
100meiotic chromosome segregation (GO:0045132)1.97321840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1POU3F2_20337985_ChIP-ChIP_501MEL_Human2.79773132
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75111874
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73467091
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69902264
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.67456343
6GBX2_23144817_ChIP-Seq_PC3_Human2.60232629
7IGF1R_20145208_ChIP-Seq_DFB_Human2.58047086
8FUS_26573619_Chip-Seq_HEK293_Human2.49533790
9ZNF274_21170338_ChIP-Seq_K562_Hela2.45437698
10VDR_22108803_ChIP-Seq_LS180_Human2.42095450
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.40369025
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38570719
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26410829
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14171381
15EWS_26573619_Chip-Seq_HEK293_Human2.13194052
16ELK1_19687146_ChIP-ChIP_HELA_Human2.03176258
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01472847
18TAF15_26573619_Chip-Seq_HEK293_Human1.99350607
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.92755668
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92442200
21P300_19829295_ChIP-Seq_ESCs_Human1.84907276
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79693283
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76194802
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.73027020
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72006054
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70099647
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67697185
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66131406
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62637393
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.58666983
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58547833
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56775519
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55021430
34ER_23166858_ChIP-Seq_MCF-7_Human1.52432366
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51569188
36SMAD4_21799915_ChIP-Seq_A2780_Human1.51501206
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50643422
38CBP_20019798_ChIP-Seq_JUKART_Human1.50643422
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44782730
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43102226
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41896106
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41160617
43IRF1_19129219_ChIP-ChIP_H3396_Human1.40026637
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39158236
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38964341
46STAT3_23295773_ChIP-Seq_U87_Human1.38824439
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38068025
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37850666
49VDR_23849224_ChIP-Seq_CD4+_Human1.37431670
50RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36757448
51MYC_18940864_ChIP-ChIP_HL60_Human1.36048963
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32671104
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32029710
54EZH2_22144423_ChIP-Seq_EOC_Human1.31120955
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30755499
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30689893
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.28709335
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.27677193
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26086686
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25948497
61* TCF4_23295773_ChIP-Seq_U87_Human1.23880041
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.22398181
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22386395
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20619454
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20217864
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19825138
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.19149907
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17613137
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16614386
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.15349047
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15283784
72BCAT_22108803_ChIP-Seq_LS180_Human1.14781501
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12948826
74RNF2_27304074_Chip-Seq_NSC_Mouse1.12681347
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11908744
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11250753
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09738887
78AR_25329375_ChIP-Seq_VCAP_Human1.09229674
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.08761717
80TCF4_22108803_ChIP-Seq_LS180_Human1.08624501
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07039515
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06805749
83TP53_22573176_ChIP-Seq_HFKS_Human1.05605281
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04415339
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04415339
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04096207
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03074803
88* SOX2_19829295_ChIP-Seq_ESCs_Human1.00975129
89* NANOG_19829295_ChIP-Seq_ESCs_Human1.00975129
90HTT_18923047_ChIP-ChIP_STHdh_Human1.00116376
91NFE2_27457419_Chip-Seq_LIVER_Mouse0.99809860
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99310866
93CDX2_22108803_ChIP-Seq_LS180_Human0.98379455
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.96355802
95FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96237676
96FLI1_21867929_ChIP-Seq_TH2_Mouse0.96192313
97FOXP3_21729870_ChIP-Seq_TREG_Human0.95173647
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94912503
99RUNX2_22187159_ChIP-Seq_PCA_Human0.94895638
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.93892518

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology2.63822080
2MP0008058_abnormal_DNA_repair2.23762734
3MP0001529_abnormal_vocalization2.17945984
4MP0008877_abnormal_DNA_methylation1.91508100
5MP0003880_abnormal_central_pattern1.89176603
6MP0005187_abnormal_penis_morphology1.87210204
7MP0003718_maternal_effect1.86436509
8MP0006276_abnormal_autonomic_nervous1.85794189
9MP0009697_abnormal_copulation1.81740787
10MP0008057_abnormal_DNA_replication1.79262360
11MP0002638_abnormal_pupillary_reflex1.78518073
12MP0003195_calcinosis1.77843543
13MP0002234_abnormal_pharynx_morphology1.75130976
14MP0006292_abnormal_olfactory_placode1.72306982
15MP0000372_irregular_coat_pigmentation1.70604750
16MP0005646_abnormal_pituitary_gland1.61461909
17MP0005645_abnormal_hypothalamus_physiol1.56635432
18MP0008789_abnormal_olfactory_epithelium1.56225199
19MP0003646_muscle_fatigue1.54846918
20MP0004145_abnormal_muscle_electrophysio1.53568129
21MP0001984_abnormal_olfaction1.51154300
22MP0003937_abnormal_limbs/digits/tail_de1.43369024
23MP0001188_hyperpigmentation1.42064635
24MP0005551_abnormal_eye_electrophysiolog1.40138870
25MP0003890_abnormal_embryonic-extraembry1.39392852
26MP0000749_muscle_degeneration1.37528288
27MP0009046_muscle_twitch1.37368923
28MP0000631_abnormal_neuroendocrine_gland1.36534759
29MP0008995_early_reproductive_senescence1.36396931
30MP0001293_anophthalmia1.36131515
31MP0001299_abnormal_eye_distance/1.34807503
32MP0002938_white_spotting1.33854144
33MP0003786_premature_aging1.32608161
34MP0009780_abnormal_chondrocyte_physiolo1.31048649
35MP0005253_abnormal_eye_physiology1.29732578
36MP0002837_dystrophic_cardiac_calcinosis1.27167799
37MP0003950_abnormal_plasma_membrane1.26794061
38MP0004270_analgesia1.23593742
39MP0000778_abnormal_nervous_system1.22144513
40MP0008007_abnormal_cellular_replicative1.21865865
41MP0002272_abnormal_nervous_system1.21534972
42MP0005394_taste/olfaction_phenotype1.20753503
43MP0005499_abnormal_olfactory_system1.20753503
44MP0002184_abnormal_innervation1.20591087
45MP0002233_abnormal_nose_morphology1.20411823
46MP0000427_abnormal_hair_cycle1.19737347
47MP0006072_abnormal_retinal_apoptosis1.18264542
48MP0000569_abnormal_digit_pigmentation1.16893929
49MP0002822_catalepsy1.16175320
50MP0004147_increased_porphyrin_level1.14831036
51MP0008932_abnormal_embryonic_tissue1.14396718
52MP0002751_abnormal_autonomic_nervous1.13977659
53MP0004924_abnormal_behavior1.12821663
54MP0005386_behavior/neurological_phenoty1.12821663
55MP0003136_yellow_coat_color1.12452643
56MP0003121_genomic_imprinting1.10396121
57MP0002160_abnormal_reproductive_system1.08291669
58MP0000647_abnormal_sebaceous_gland1.08124625
59MP0004142_abnormal_muscle_tone1.07216124
60MP0009745_abnormal_behavioral_response1.06643078
61MP0001764_abnormal_homeostasis1.05089216
62MP0010094_abnormal_chromosome_stability1.04997841
63MP0003755_abnormal_palate_morphology1.03711541
64MP0005085_abnormal_gallbladder_physiolo1.03447948
65MP0006035_abnormal_mitochondrial_morpho1.02402864
66MP0004957_abnormal_blastocyst_morpholog1.01771048
67MP0004215_abnormal_myocardial_fiber0.99936650
68MP0002210_abnormal_sex_determination0.97078752
69MP0002876_abnormal_thyroid_physiology0.94316017
70MP0001929_abnormal_gametogenesis0.93860204
71MP0003122_maternal_imprinting0.93301087
72MP0002735_abnormal_chemical_nociception0.92221806
73MP0005389_reproductive_system_phenotype0.90057175
74MP0001486_abnormal_startle_reflex0.88974478
75MP0003693_abnormal_embryo_hatching0.88375875
76MP0002736_abnormal_nociception_after0.87605065
77MP0002734_abnormal_mechanical_nocicepti0.86264674
78MP0001968_abnormal_touch/_nociception0.85780674
79MP0005391_vision/eye_phenotype0.85002336
80MP0005395_other_phenotype0.84523887
81MP0000955_abnormal_spinal_cord0.83793834
82MP0001324_abnormal_eye_pigmentation0.83719569
83MP0003941_abnormal_skin_development0.83455120
84MP0004043_abnormal_pH_regulation0.83043087
85MP0002282_abnormal_trachea_morphology0.82490903
86MP0002752_abnormal_somatic_nervous0.81844405
87MP0000653_abnormal_sex_gland0.81724590
88MP0002557_abnormal_social/conspecific_i0.81597007
89MP0003567_abnormal_fetal_cardiomyocyte0.81112163
90MP0002067_abnormal_sensory_capabilities0.80186083
91MP0003698_abnormal_male_reproductive0.79843441
92MP0002332_abnormal_exercise_endurance0.79725528
93MP0001286_abnormal_eye_development0.78440423
94MP0000049_abnormal_middle_ear0.77820718
95MP0003119_abnormal_digestive_system0.77814285
96MP0006036_abnormal_mitochondrial_physio0.76740244
97MP0001919_abnormal_reproductive_system0.75992332
98MP0003787_abnormal_imprinting0.75918388
99MP0000383_abnormal_hair_follicle0.74582839
100MP0002269_muscular_atrophy0.74450180

Predicted human phenotypes

RankGene SetZ-score
1Medial flaring of the eyebrow (HP:0010747)3.09229148
2Colon cancer (HP:0003003)2.84182692
3Gait imbalance (HP:0002141)2.65108969
4Congenital primary aphakia (HP:0007707)2.64157296
5Pancreatic cysts (HP:0001737)2.62691247
6Pancreatic fibrosis (HP:0100732)2.54980887
7Acute necrotizing encephalopathy (HP:0006965)2.47306283
8Acute encephalopathy (HP:0006846)2.46185658
9Nephrogenic diabetes insipidus (HP:0009806)2.42741175
10Medulloblastoma (HP:0002885)2.42300714
11Abnormality of the labia minora (HP:0012880)2.41567862
12Abnormality of the astrocytes (HP:0100707)2.41388274
13Astrocytoma (HP:0009592)2.41388274
14True hermaphroditism (HP:0010459)2.37095975
15Genital tract atresia (HP:0001827)2.34480392
16Abnormal mitochondria in muscle tissue (HP:0008316)2.30802147
17Thyroid-stimulating hormone excess (HP:0002925)2.29830084
18Vaginal atresia (HP:0000148)2.28854822
19Gaze-evoked nystagmus (HP:0000640)2.27526750
20Progressive macrocephaly (HP:0004481)2.26463717
21Type 2 muscle fiber atrophy (HP:0003554)2.25211728
22Increased CSF lactate (HP:0002490)2.20616325
23Glioma (HP:0009733)2.18897063
24Ependymoma (HP:0002888)2.18560804
25Type II lissencephaly (HP:0007260)2.12319487
26Neuroendocrine neoplasm (HP:0100634)2.12278878
27Proximal tubulopathy (HP:0000114)2.12181368
28Nephronophthisis (HP:0000090)2.11879155
29Progressive inability to walk (HP:0002505)2.07456833
30Mitochondrial inheritance (HP:0001427)2.07042630
31Hypothermia (HP:0002045)2.06390841
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.04490693
33Cerebellar dysplasia (HP:0007033)2.02653701
34Abnormality of midbrain morphology (HP:0002418)2.02602582
35Molar tooth sign on MRI (HP:0002419)2.02602582
36Poor coordination (HP:0002370)2.02306086
37Hepatocellular necrosis (HP:0001404)2.02083937
38Hepatic necrosis (HP:0002605)1.98797527
39Pheochromocytoma (HP:0002666)1.98784664
40Inability to walk (HP:0002540)1.98371446
41Volvulus (HP:0002580)1.97307100
42Optic nerve hypoplasia (HP:0000609)1.96144021
43Lissencephaly (HP:0001339)1.95710257
44Tubulointerstitial nephritis (HP:0001970)1.94752051
45Abnormality of chromosome stability (HP:0003220)1.90728493
46Abnormality of alanine metabolism (HP:0010916)1.90620382
47Hyperalaninemia (HP:0003348)1.90620382
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90620382
49Aplasia/Hypoplasia of the tongue (HP:0010295)1.89615335
50Exercise-induced muscle cramps (HP:0003710)1.89104863
51Cerebral edema (HP:0002181)1.87329455
52Hyperglycinemia (HP:0002154)1.87215260
53Hypomagnesemia (HP:0002917)1.87004511
54Renal cortical cysts (HP:0000803)1.86661202
55Aplasia/Hypoplasia of the tibia (HP:0005772)1.85333053
56Lipid accumulation in hepatocytes (HP:0006561)1.84696223
57Increased serum lactate (HP:0002151)1.84086065
58Abnormality of the renal cortex (HP:0011035)1.82091190
59Drooling (HP:0002307)1.81922607
60Calf muscle hypertrophy (HP:0008981)1.81758241
61Sclerocornea (HP:0000647)1.80215884
62Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80185480
63Biliary tract neoplasm (HP:0100574)1.78937569
64Broad-based gait (HP:0002136)1.76732780
65Specific learning disability (HP:0001328)1.75748009
66Chromsome breakage (HP:0040012)1.75525166
67Abnormality of the renal medulla (HP:0100957)1.75343754
68Chronic hepatic failure (HP:0100626)1.74552884
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72677045
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72607186
71Astigmatism (HP:0000483)1.71390745
72Postaxial hand polydactyly (HP:0001162)1.71003376
73Nemaline bodies (HP:0003798)1.70917630
74Increased hepatocellular lipid droplets (HP:0006565)1.70111369
75Rimmed vacuoles (HP:0003805)1.68332522
76Preaxial hand polydactyly (HP:0001177)1.67755446
77Short tibia (HP:0005736)1.66803702
78Degeneration of the lateral corticospinal tracts (HP:0002314)1.65833478
79Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.65833478
80Sloping forehead (HP:0000340)1.65693268
81Rhabdomyosarcoma (HP:0002859)1.65286763
82Lactic acidosis (HP:0003128)1.64442949
83Abnormality of the ileum (HP:0001549)1.63820238
84Methylmalonic acidemia (HP:0002912)1.63547182
85Meckel diverticulum (HP:0002245)1.63159256
86Hypoplastic pelvis (HP:0008839)1.62285661
87Hypobetalipoproteinemia (HP:0003563)1.62166966
88Muscle fiber atrophy (HP:0100295)1.61913227
89Muscle hypertrophy of the lower extremities (HP:0008968)1.59877118
90Postaxial foot polydactyly (HP:0001830)1.59759568
91Abnormality of macular pigmentation (HP:0008002)1.59497417
92Muscular hypotonia of the trunk (HP:0008936)1.59072594
93Pachygyria (HP:0001302)1.58948035
94Bifid tongue (HP:0010297)1.58777482
95Abnormality of serum amino acid levels (HP:0003112)1.58677093
96Neonatal respiratory distress (HP:0002643)1.58022677
97Anencephaly (HP:0002323)1.57725944
98Papillary thyroid carcinoma (HP:0002895)1.56804167
99Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.56443887
100Tubular atrophy (HP:0000092)1.54234055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.10702720
2ZAK3.05408842
3BMPR1B2.58264248
4TRIM282.49487484
5CASK2.45299112
6WNK32.17960809
7MST42.14184377
8BCR2.11871374
9PBK2.10918429
10ERBB32.08178181
11STK392.06426000
12TNIK2.05352577
13MAP3K42.02959772
14PINK12.01312622
15TSSK61.95748002
16BUB11.94379471
17OBSCN1.90056131
18BRSK21.85310370
19MAP2K71.74298467
20MKNK21.62299813
21EIF2AK31.61709379
22NEK11.57694358
23NUAK11.50117540
24WEE11.46988496
25MAP4K21.46276179
26MARK11.42683651
27CSNK1G11.41541639
28OXSR11.33963248
29ACVR1B1.29021299
30PLK31.27970561
31CSNK1G31.24862287
32CSNK1A1L1.24413463
33STK38L1.20896474
34CCNB11.20297398
35VRK11.19858742
36PLK41.15894662
37WNK41.15323825
38MAP3K121.15284609
39PNCK1.14184032
40STK161.12319704
41CSNK1G21.11197228
42PLK21.11110233
43EPHA41.07414658
44TTK1.06376624
45TLK10.99721442
46MAPK130.99579169
47CAMKK20.99488539
48SRPK10.98700669
49PLK10.97525013
50PHKG20.96282012
51PHKG10.96282012
52CDC70.93488321
53GRK10.92697788
54MKNK10.92628681
55PRKCG0.92295843
56PAK30.87817693
57MINK10.86629793
58EIF2AK10.84530417
59PRKCE0.79574698
60MAP2K40.74114978
61AKT30.73278945
62MUSK0.73274633
63RPS6KA50.73137305
64PDK20.71825708
65ATM0.66736671
66ADRBK20.65066395
67MST1R0.62397776
68CDK80.62016245
69BCKDK0.61775391
70MET0.61132243
71BRSK10.60198122
72CAMK2A0.60137159
73PIK3CA0.59591772
74ATR0.58764097
75INSRR0.56660437
76LIMK10.54204767
77FER0.54203053
78DYRK20.52788528
79DYRK30.52724423
80CHEK20.52063824
81NLK0.51041723
82LATS10.47303891
83STK30.46841645
84NME10.46768235
85NTRK20.45293343
86CSNK1E0.45085597
87PRKAA10.45041616
88AURKB0.44866949
89FGFR10.41339124
90EPHA30.40243535
91EIF2AK20.39931965
92LMTK20.39769503
93CAMK2G0.36495318
94NTRK30.36399403
95NEK20.36332587
96CAMK2D0.35721659
97PKN10.34744333
98PRKCI0.34668608
99ERBB40.33768598
100FGFR20.33407458

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.46536853
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20571042
3Propanoate metabolism_Homo sapiens_hsa006402.19206924
4Proteasome_Homo sapiens_hsa030502.16803506
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.15591106
6Butanoate metabolism_Homo sapiens_hsa006502.14012673
7Basal transcription factors_Homo sapiens_hsa030222.03714113
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98909008
9Oxidative phosphorylation_Homo sapiens_hsa001901.88093937
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85281561
11Fanconi anemia pathway_Homo sapiens_hsa034601.82123614
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80993733
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77863008
14Parkinsons disease_Homo sapiens_hsa050121.77461391
15Non-homologous end-joining_Homo sapiens_hsa034501.66202551
16Homologous recombination_Homo sapiens_hsa034401.64532199
17Caffeine metabolism_Homo sapiens_hsa002321.63944063
18RNA polymerase_Homo sapiens_hsa030201.63426152
19RNA degradation_Homo sapiens_hsa030181.62504436
20Nicotine addiction_Homo sapiens_hsa050331.58638026
21Vitamin B6 metabolism_Homo sapiens_hsa007501.50900409
22Selenocompound metabolism_Homo sapiens_hsa004501.43293696
23Mismatch repair_Homo sapiens_hsa034301.40442635
24Circadian rhythm_Homo sapiens_hsa047101.37479153
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.36341375
26Steroid biosynthesis_Homo sapiens_hsa001001.35516175
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32965637
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31026836
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28980196
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28359771
31Huntingtons disease_Homo sapiens_hsa050161.28243521
32Peroxisome_Homo sapiens_hsa041461.27240832
33RNA transport_Homo sapiens_hsa030131.26114614
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19611726
35Tryptophan metabolism_Homo sapiens_hsa003801.11408774
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10748777
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.10651978
38One carbon pool by folate_Homo sapiens_hsa006701.09176704
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07338382
40beta-Alanine metabolism_Homo sapiens_hsa004101.06176511
41Fatty acid elongation_Homo sapiens_hsa000621.05725404
42Alzheimers disease_Homo sapiens_hsa050101.05093265
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04998422
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02892707
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02624105
46Nucleotide excision repair_Homo sapiens_hsa034201.01808503
47Alcoholism_Homo sapiens_hsa050341.00096173
48Arginine and proline metabolism_Homo sapiens_hsa003300.98088874
49Retinol metabolism_Homo sapiens_hsa008300.97861577
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97085422
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96026094
52Phototransduction_Homo sapiens_hsa047440.95925666
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94695499
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94296187
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.93146255
56Fatty acid degradation_Homo sapiens_hsa000710.93029481
57Purine metabolism_Homo sapiens_hsa002300.92226746
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92067773
59Pyruvate metabolism_Homo sapiens_hsa006200.90751008
60Regulation of autophagy_Homo sapiens_hsa041400.89846767
61Fatty acid metabolism_Homo sapiens_hsa012120.87240736
62Sphingolipid metabolism_Homo sapiens_hsa006000.87064589
63GABAergic synapse_Homo sapiens_hsa047270.86598427
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86163997
65Cardiac muscle contraction_Homo sapiens_hsa042600.86083825
66Pyrimidine metabolism_Homo sapiens_hsa002400.85357237
67Nitrogen metabolism_Homo sapiens_hsa009100.85148554
68Sulfur metabolism_Homo sapiens_hsa009200.85063924
69Folate biosynthesis_Homo sapiens_hsa007900.82856759
70Metabolic pathways_Homo sapiens_hsa011000.79221319
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.78641348
72Carbon metabolism_Homo sapiens_hsa012000.69740036
73Vitamin digestion and absorption_Homo sapiens_hsa049770.68501351
74Cell cycle_Homo sapiens_hsa041100.67080638
75Oocyte meiosis_Homo sapiens_hsa041140.65465670
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65392557
77Arginine biosynthesis_Homo sapiens_hsa002200.64859144
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64486876
79Systemic lupus erythematosus_Homo sapiens_hsa053220.63532642
80Sulfur relay system_Homo sapiens_hsa041220.63487810
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63101057
82Tyrosine metabolism_Homo sapiens_hsa003500.63018003
83Biosynthesis of amino acids_Homo sapiens_hsa012300.62592575
84Hedgehog signaling pathway_Homo sapiens_hsa043400.62400239
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62057024
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61731898
87Olfactory transduction_Homo sapiens_hsa047400.61446106
88Base excision repair_Homo sapiens_hsa034100.60814369
89Chemical carcinogenesis_Homo sapiens_hsa052040.60775291
90Linoleic acid metabolism_Homo sapiens_hsa005910.59279215
91Taste transduction_Homo sapiens_hsa047420.55786611
92DNA replication_Homo sapiens_hsa030300.53470509
93ABC transporters_Homo sapiens_hsa020100.50919654
94Hippo signaling pathway_Homo sapiens_hsa043900.48237175
95Fat digestion and absorption_Homo sapiens_hsa049750.47528230
96Dopaminergic synapse_Homo sapiens_hsa047280.47457211
97Fatty acid biosynthesis_Homo sapiens_hsa000610.46701806
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.45401360
99Starch and sucrose metabolism_Homo sapiens_hsa005000.45142119
100Insulin secretion_Homo sapiens_hsa049110.43321947

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