ASAH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)7.77661849
2intestinal absorption (GO:0050892)7.24968906
3angiotensin maturation (GO:0002003)6.60757606
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.01300395
5phospholipid efflux (GO:0033700)5.39682768
6regulation of triglyceride catabolic process (GO:0010896)5.30042256
7regulation of cholesterol esterification (GO:0010872)4.93567499
8drug catabolic process (GO:0042737)4.93472046
9positive regulation of triglyceride lipase activity (GO:0061365)4.83949754
10positive regulation of lipoprotein lipase activity (GO:0051006)4.83949754
11uronic acid metabolic process (GO:0006063)4.79096285
12glucuronate metabolic process (GO:0019585)4.79096285
13regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.70238140
14cholesterol efflux (GO:0033344)4.62295343
15plasma lipoprotein particle assembly (GO:0034377)4.53908140
16flavonoid metabolic process (GO:0009812)4.53758296
17reverse cholesterol transport (GO:0043691)4.45286668
18hormone catabolic process (GO:0042447)4.43121818
19high-density lipoprotein particle remodeling (GO:0034375)4.43087190
20protein-lipid complex assembly (GO:0065005)4.35649040
21lipoprotein metabolic process (GO:0042157)4.20809448
22L-phenylalanine catabolic process (GO:0006559)4.05340593
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.05340593
24negative regulation of sterol transport (GO:0032372)4.04271745
25negative regulation of cholesterol transport (GO:0032375)4.04271745
26cholesterol homeostasis (GO:0042632)4.00019921
27sterol homeostasis (GO:0055092)3.97543390
28plasma lipoprotein particle remodeling (GO:0034369)3.96853530
29protein-lipid complex remodeling (GO:0034368)3.96853530
30macromolecular complex remodeling (GO:0034367)3.96853530
31very-low-density lipoprotein particle assembly (GO:0034379)3.96211707
32alpha-linolenic acid metabolic process (GO:0036109)3.90851405
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.86136648
34L-phenylalanine metabolic process (GO:0006558)3.86136648
35urea cycle (GO:0000050)3.85642834
36urea metabolic process (GO:0019627)3.85642834
37regulation of bile acid biosynthetic process (GO:0070857)3.85198381
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.79732933
39cysteine metabolic process (GO:0006534)3.76452292
40drug transmembrane transport (GO:0006855)3.75174900
41regulation of cholesterol homeostasis (GO:2000188)3.72359905
42adhesion of symbiont to host cell (GO:0044650)3.71706725
43virion attachment to host cell (GO:0019062)3.71706725
44positive regulation of lipid catabolic process (GO:0050996)3.71619309
45positive regulation of fatty acid biosynthetic process (GO:0045723)3.71565473
46triglyceride homeostasis (GO:0070328)3.68788041
47acylglycerol homeostasis (GO:0055090)3.68788041
48cholesterol transport (GO:0030301)3.67597521
49sterol transport (GO:0015918)3.67597521
50vitamin A metabolic process (GO:0006776)3.65765935
51epoxygenase P450 pathway (GO:0019373)3.60780554
52plasma lipoprotein particle clearance (GO:0034381)3.55790522
53lysine metabolic process (GO:0006553)3.53410715
54lysine catabolic process (GO:0006554)3.53410715
55homocysteine metabolic process (GO:0050667)3.48738009
56nitrogen cycle metabolic process (GO:0071941)3.46451164
57nuclear pore complex assembly (GO:0051292)3.43805475
58positive regulation of triglyceride metabolic process (GO:0090208)3.43725962
59plasma lipoprotein particle organization (GO:0071827)3.41396074
60mRNA modification (GO:0016556)3.40185370
61aromatic amino acid family catabolic process (GO:0009074)3.39562137
62protein-lipid complex subunit organization (GO:0071825)3.38052858
63NADH metabolic process (GO:0006734)3.37245466
64drug transport (GO:0015893)3.36203518
65lipoprotein transport (GO:0042953)3.35948315
66adhesion of symbiont to host (GO:0044406)3.34092173
67peptide catabolic process (GO:0043171)3.32518610
68phospholipid homeostasis (GO:0055091)3.31402532
69exogenous drug catabolic process (GO:0042738)3.26510905
70response to phenylpropanoid (GO:0080184)3.25713823
71regulation of lipoprotein metabolic process (GO:0050746)3.24665734
72drug metabolic process (GO:0017144)3.22358013
73nuclear pore organization (GO:0006999)3.21521973
74fat-soluble vitamin biosynthetic process (GO:0042362)3.20641076
753-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.20475564
76purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.20475564
77regulation of guanylate cyclase activity (GO:0031282)3.20301531
78lipid homeostasis (GO:0055088)3.19222099
79amino-acid betaine metabolic process (GO:0006577)3.12719420
80negative regulation of digestive system process (GO:0060457)3.11940842
81bile acid and bile salt transport (GO:0015721)3.11514310
82glyoxylate metabolic process (GO:0046487)3.10453637
83transepithelial transport (GO:0070633)3.09819856
84heme transport (GO:0015886)3.09510975
85transcytosis (GO:0045056)3.08247787
86regulation of sterol transport (GO:0032371)3.05428323
87regulation of cholesterol transport (GO:0032374)3.05428323
88drinking behavior (GO:0042756)3.05207406
89digestive system process (GO:0022600)3.03102895
90peptide hormone processing (GO:0016486)3.03018543
91bile acid biosynthetic process (GO:0006699)3.01545183
92modified amino acid transport (GO:0072337)3.01285254
93low-density lipoprotein particle clearance (GO:0034383)3.00578767
94very long-chain fatty acid metabolic process (GO:0000038)2.99658351
95vitamin transmembrane transport (GO:0035461)2.99457667
96COPII vesicle coating (GO:0048208)2.99271040
97positive regulation of guanylate cyclase activity (GO:0031284)2.99168921
98positive regulation of dendritic spine morphogenesis (GO:0061003)2.94716597
99urate metabolic process (GO:0046415)2.94288276
100bile acid metabolic process (GO:0008206)2.91360734
101cellular glucuronidation (GO:0052695)2.91055360
102positive regulation of steroid metabolic process (GO:0045940)2.88873440
103glutamate metabolic process (GO:0006536)2.87418464
104attachment of spindle microtubules to kinetochore (GO:0008608)2.87243197
105regulation of triglyceride metabolic process (GO:0090207)2.86814454
106glucose 6-phosphate metabolic process (GO:0051156)2.86452895
107diacylglycerol metabolic process (GO:0046339)2.86334295
108fatty acid beta-oxidation (GO:0006635)2.85996082
109digestion (GO:0007586)2.85803735
110kynurenine metabolic process (GO:0070189)2.83939461
111indole-containing compound catabolic process (GO:0042436)2.82902980
112indolalkylamine catabolic process (GO:0046218)2.82902980
113tryptophan catabolic process (GO:0006569)2.82902980
114fatty acid catabolic process (GO:0009062)2.82401086
115sulfur amino acid catabolic process (GO:0000098)2.81964607
116cellular modified amino acid catabolic process (GO:0042219)2.80802793
117positive regulation of fatty acid metabolic process (GO:0045923)2.79697075
118alkaloid metabolic process (GO:0009820)2.78316566
119proline transport (GO:0015824)2.78091428
120regulation of centriole replication (GO:0046599)2.75342861
121fatty acid oxidation (GO:0019395)2.74197211
122oxidative demethylation (GO:0070989)2.69710846
123DNA demethylation (GO:0080111)2.69696949
124sulfate transmembrane transport (GO:1902358)2.66177373
125regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.65403266
126endocrine process (GO:0050886)2.65403266
127regulation of systemic arterial blood pressure by hormone (GO:0001990)2.65403266
128vitamin biosynthetic process (GO:0009110)2.64428430
129glycerol metabolic process (GO:0006071)2.63389951
130intestinal epithelial cell development (GO:0060576)2.62314815
131cytidine deamination (GO:0009972)2.62093945
132cytidine metabolic process (GO:0046087)2.62093945
133cytidine catabolic process (GO:0006216)2.62093945
134DNA double-strand break processing (GO:0000729)2.59862052
135negative regulation of gene silencing (GO:0060969)2.56865515
136midgut development (GO:0007494)2.55831503
137quinone biosynthetic process (GO:1901663)2.54988565
138proline biosynthetic process (GO:0006561)2.52706742
139sulfate transport (GO:0008272)2.52390265
140arginine metabolic process (GO:0006525)2.50733864
141fat-soluble vitamin metabolic process (GO:0006775)2.50221915
142glycine transport (GO:0015816)2.48877000
143sphingomyelin metabolic process (GO:0006684)2.48259447
144metaphase plate congression (GO:0051310)2.47923560
145alditol metabolic process (GO:0019400)2.47465234
146coenzyme catabolic process (GO:0009109)2.46638290
147regulation of cilium movement (GO:0003352)2.45986189
148fructose metabolic process (GO:0006000)2.45521897
149C4-dicarboxylate transport (GO:0015740)2.44831522
150regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.43055813
151bundle of His cell to Purkinje myocyte communication (GO:0086069)2.42135555
152glutamine family amino acid biosynthetic process (GO:0009084)2.41711778
153omega-hydroxylase P450 pathway (GO:0097267)2.39737505
154positive regulation of glycoprotein biosynthetic process (GO:0010560)2.39684253
155sulfur compound transport (GO:0072348)2.39644689
156phenylpropanoid metabolic process (GO:0009698)2.38420039
157regulation of pigment cell differentiation (GO:0050932)2.35887194
158mitotic sister chromatid cohesion (GO:0007064)2.34762061
159DNA dealkylation (GO:0035510)2.31792775
160quinone metabolic process (GO:1901661)2.31791769
161citrulline biosynthetic process (GO:0019240)2.30698024
162pore complex assembly (GO:0046931)2.30096840
163synapsis (GO:0007129)2.29529039
164zinc ion transport (GO:0006829)2.28489231
165neutral amino acid transport (GO:0015804)2.28301573
166cobalamin metabolic process (GO:0009235)2.27302460
167vitamin transport (GO:0051180)2.26902931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.26193647
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.70175693
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.21460685
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.19430246
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.18531091
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.45300485
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.35209364
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.30467964
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.94139915
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.87273387
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.85722932
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.77397929
13VDR_22108803_ChIP-Seq_LS180_Human2.76832569
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59244410
15IGF1R_20145208_ChIP-Seq_DFB_Human2.56289332
16FUS_26573619_Chip-Seq_HEK293_Human2.45308518
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.41606691
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38988754
19AR_21909140_ChIP-Seq_LNCAP_Human2.36459381
20E2F7_22180533_ChIP-Seq_HELA_Human2.35577419
21SOX2_27498859_Chip-Seq_STOMACH_Mouse2.21133720
22ZNF274_21170338_ChIP-Seq_K562_Hela2.20880259
23GATA1_22025678_ChIP-Seq_K562_Human2.10993446
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97789903
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.92934844
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92168734
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.91490351
28EWS_26573619_Chip-Seq_HEK293_Human1.88810962
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.87984419
30GBX2_23144817_ChIP-Seq_PC3_Human1.87432400
31TAF15_26573619_Chip-Seq_HEK293_Human1.87190930
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84768029
33GATA4_25053715_ChIP-Seq_YYC3_Human1.84654796
34P300_19829295_ChIP-Seq_ESCs_Human1.81372719
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79541586
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77868386
37ELK1_19687146_ChIP-ChIP_HELA_Human1.76514932
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69487646
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.69414712
40CLOCK_20551151_ChIP-Seq_293T_Human1.68362562
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68212576
42* FOXA2_19822575_ChIP-Seq_HepG2_Human1.65686092
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.64249982
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63834206
45SOX2_20726797_ChIP-Seq_SW620_Human1.61437545
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58762820
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58661702
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58347874
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58133503
50ER_23166858_ChIP-Seq_MCF-7_Human1.56943443
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56933525
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55300750
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52598152
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.48606158
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48286188
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48268162
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.47601477
58* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46323326
59STAT3_23295773_ChIP-Seq_U87_Human1.45280467
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45107067
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.44555585
62* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43132982
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39427211
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38448173
65SMAD4_21799915_ChIP-Seq_A2780_Human1.38382917
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.37790948
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37285448
68* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37241946
69* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35888414
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35466922
71CBP_20019798_ChIP-Seq_JUKART_Human1.34237564
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34237564
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34186276
74GATA6_25053715_ChIP-Seq_YYC3_Human1.33376447
75MYC_18940864_ChIP-ChIP_HL60_Human1.29997250
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28540072
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26992253
78* FOXO3_23340844_ChIP-Seq_DLD1_Human1.26858701
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.25489616
80* HNF4A_19822575_ChIP-Seq_HepG2_Human1.24905078
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24642002
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24627688
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24147678
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23574123
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.23572711
86* TCF4_22108803_ChIP-Seq_LS180_Human1.22957688
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22784435
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20556649
89* SMAD3_21741376_ChIP-Seq_EPCs_Human1.20363491
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.19977603
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19494403
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19386303
93IRF1_19129219_ChIP-ChIP_H3396_Human1.18613543
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.17059615
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16460229
96SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16385277
97FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16102112
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15911321
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15849686
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15749418
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15746113
102* TCF4_23295773_ChIP-Seq_U87_Human1.15584795
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15286614
104TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.14238294
105CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13382151
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12045657
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.11651898
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.10369179
109* GATA2_19941826_ChIP-Seq_K562_Human1.08396529
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07008887
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06262103
112NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06262103
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06187543
114P53_22387025_ChIP-Seq_ESCs_Mouse1.06126179
115* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04220733
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02318850
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02000810
118FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01832940
119SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01320600
120* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01245690
121* TP63_23658742_ChIP-Seq_EP156T_Human1.00672917
122CMYC_18555785_Chip-Seq_ESCs_Mouse1.00517150
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00471436
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00037596
125SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99058778
126RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98745982
127GATA1_19941826_ChIP-Seq_K562_Human0.98052290
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97506081
129SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97492576
130TP53_18474530_ChIP-ChIP_U2OS_Human0.97312293
131FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97164159
132TCF4_18268006_ChIP-ChIP_LS174T_Human0.97081781
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95929902
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95469025
135P300_18555785_Chip-Seq_ESCs_Mouse0.95331651
136SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95006596
137OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94808701
138CJUN_26792858_Chip-Seq_BT549_Human0.94781721
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.94586278
140PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94442710
141AR_25329375_ChIP-Seq_VCAP_Human0.94401073
142* NANOG_19829295_ChIP-Seq_ESCs_Human0.93793249
143* SOX2_19829295_ChIP-Seq_ESCs_Human0.93793249
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.89524724
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89177032
146IRF8_22096565_ChIP-ChIP_GC-B_Human0.88788637
147EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87984798
148KLF5_25053715_ChIP-Seq_YYC3_Human0.86815886
149FOXA1_25552417_ChIP-Seq_VCAP_Human0.86220441
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85836732
151KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84355361
152ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83538204
153RUNX1_27514584_Chip-Seq_MCF-7_Human0.83508185
154CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82909159
155STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81688347
156ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80839693
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80801786
158EGR1_19032775_ChIP-ChIP_M12_Human0.80146602
159PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79614173
160NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79203291
161CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78981767
162HTT_18923047_ChIP-ChIP_STHdh_Human0.78606562
163KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.78319020
164RXR_22108803_ChIP-Seq_LS180_Human0.77959912
165AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77548589
166BCAT_22108803_ChIP-Seq_LS180_Human0.77436694
167AHR_22903824_ChIP-Seq_MCF-7_Human0.77349714
168MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76085558
169TBX20_22328084_ChIP-Seq_HEART_Mouse0.76033817
170TBX20_22080862_ChIP-Seq_HEART_Mouse0.76033817
171P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74912449
172GATA3_24758297_ChIP-Seq_MCF-7_Human0.74784371
173RACK7_27058665_Chip-Seq_MCF-7_Human0.74254292
174TP53_16413492_ChIP-PET_HCT116_Human0.74012317
175FOXM1_26456572_ChIP-Seq_MCF-7_Human0.71328904
176SMAD3_21741376_ChIP-Seq_HESCs_Human0.70415471
177* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70219310
178* CDX2_22108803_ChIP-Seq_LS180_Human0.69495474
179SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.69092403
180ARNT_22903824_ChIP-Seq_MCF-7_Human0.68934768
181* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68624227
182* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.67599991
183DROSHA_22980978_ChIP-Seq_HELA_Human0.66852051
184SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.65780847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.75515892
2MP0002139_abnormal_hepatobiliary_system6.08103236
3MP0001666_abnormal_nutrient_absorption4.76497756
4MP0005085_abnormal_gallbladder_physiolo4.59617579
5MP0008875_abnormal_xenobiotic_pharmacok4.05947636
6MP0003252_abnormal_bile_duct3.99331135
7MP0009840_abnormal_foam_cell3.95760903
8MP0005365_abnormal_bile_salt3.82747410
9MP0003718_maternal_effect3.37549103
10MP0010329_abnormal_lipoprotein_level3.21822026
11MP0010234_abnormal_vibrissa_follicle2.47746901
12MP0004019_abnormal_vitamin_homeostasis2.26690103
13MP0008057_abnormal_DNA_replication2.25784374
14MP0003191_abnormal_cellular_cholesterol2.25688442
15MP0003183_abnormal_peptide_metabolism2.23354382
16MP0005332_abnormal_amino_acid2.16326498
17MP0004043_abnormal_pH_regulation2.06219926
18MP0003806_abnormal_nucleotide_metabolis2.03391151
19MP0002102_abnormal_ear_morphology1.86788488
20MP0003195_calcinosis1.85382112
21* MP0002118_abnormal_lipid_homeostasis1.79650769
22MP0004957_abnormal_blastocyst_morpholog1.72742342
23MP0004264_abnormal_extraembryonic_tissu1.69193604
24MP0002796_impaired_skin_barrier1.68530212
25MP0008058_abnormal_DNA_repair1.66799880
26MP0003941_abnormal_skin_development1.64131561
27MP0003705_abnormal_hypodermis_morpholog1.61803177
28MP0000609_abnormal_liver_physiology1.60105689
29MP0003693_abnormal_embryo_hatching1.58495511
30MP0003300_gastrointestinal_ulcer1.53554884
31MP0003890_abnormal_embryonic-extraembry1.52001837
32MP0002254_reproductive_system_inflammat1.51651282
33MP0005451_abnormal_body_composition1.50108229
34MP0009643_abnormal_urine_homeostasis1.49669592
35MP0005083_abnormal_biliary_tract1.49183417
36MP0005395_other_phenotype1.45486355
37MP0005084_abnormal_gallbladder_morpholo1.43405792
38MP0010094_abnormal_chromosome_stability1.35391969
39MP0001188_hyperpigmentation1.34973096
40MP0004270_analgesia1.33367937
41MP0009697_abnormal_copulation1.33020862
42MP0009780_abnormal_chondrocyte_physiolo1.31755455
43MP0000462_abnormal_digestive_system1.27895660
44MP0005319_abnormal_enzyme/_coenzyme1.26557034
45MP0005448_abnormal_energy_balance1.22556349
46MP0001293_anophthalmia1.18521399
47MP0005645_abnormal_hypothalamus_physiol1.17427214
48MP0008877_abnormal_DNA_methylation1.17136054
49MP0001529_abnormal_vocalization1.16773893
50MP0008932_abnormal_embryonic_tissue1.13858276
51MP0008789_abnormal_olfactory_epithelium1.13805871
52MP0003111_abnormal_nucleus_morphology1.12731207
53MP0004147_increased_porphyrin_level1.11206584
54MP0005584_abnormal_enzyme/coenzyme_acti1.10180666
55MP0003937_abnormal_limbs/digits/tail_de1.05022007
56MP0002234_abnormal_pharynx_morphology1.04918892
57MP0003868_abnormal_feces_composition1.03101102
58MP0002638_abnormal_pupillary_reflex1.02406423
59MP0002138_abnormal_hepatobiliary_system1.00180530
60MP0001764_abnormal_homeostasis0.96937998
61MP0002822_catalepsy0.96727828
62MP0000604_amyloidosis0.96435689
63MP0000538_abnormal_urinary_bladder0.95974176
64MP0003122_maternal_imprinting0.95767941
65MP0004947_skin_inflammation0.95127600
66MP0001501_abnormal_sleep_pattern0.94346308
67MP0005551_abnormal_eye_electrophysiolog0.92736207
68MP0002697_abnormal_eye_size0.91522099
69MP0005394_taste/olfaction_phenotype0.90764219
70MP0005499_abnormal_olfactory_system0.90764219
71MP0003866_abnormal_defecation0.90384075
72MP0001765_abnormal_ion_homeostasis0.90257254
73MP0002938_white_spotting0.89800049
74MP0002233_abnormal_nose_morphology0.88508004
75MP0005167_abnormal_blood-brain_barrier0.86582299
76MP0005636_abnormal_mineral_homeostasis0.85794463
77MP0002876_abnormal_thyroid_physiology0.84617823
78MP0009764_decreased_sensitivity_to0.83734087
79MP0010678_abnormal_skin_adnexa0.83353727
80MP0002971_abnormal_brown_adipose0.82855053
81MP0010386_abnormal_urinary_bladder0.82770881
82MP0002078_abnormal_glucose_homeostasis0.82559449
83MP0006072_abnormal_retinal_apoptosis0.82032814
84MP0006054_spinal_hemorrhage0.82021234
85MP0009384_cardiac_valve_regurgitation0.81648893
86MP0001929_abnormal_gametogenesis0.81392808
87MP0002751_abnormal_autonomic_nervous0.80526683
88MP0008872_abnormal_physiological_respon0.80467196
89MP0005501_abnormal_skin_physiology0.80097999
90MP0003121_genomic_imprinting0.79674737
91MP0005187_abnormal_penis_morphology0.78161569
92MP0002136_abnormal_kidney_physiology0.77682551
93MP0005666_abnormal_adipose_tissue0.76825630
94MP0001664_abnormal_digestion0.76473516
95MP0001756_abnormal_urination0.75804746
96MP0001730_embryonic_growth_arrest0.75672201
97MP0001324_abnormal_eye_pigmentation0.74442274
98MP0009642_abnormal_blood_homeostasis0.73908334
99MP0005334_abnormal_fat_pad0.73773693
100MP0003690_abnormal_glial_cell0.73711426
101MP0002160_abnormal_reproductive_system0.73606727
102MP0009765_abnormal_xenobiotic_induced0.73004570
103MP0003656_abnormal_erythrocyte_physiolo0.71371272
104MP0000598_abnormal_liver_morphology0.70924482
105MP0005253_abnormal_eye_physiology0.68569268
106MP0000230_abnormal_systemic_arterial0.68487122
107MP0004215_abnormal_myocardial_fiber0.68469608
108MP0003077_abnormal_cell_cycle0.68308245
109MP0005381_digestive/alimentary_phenotyp0.68134355
110MP0003221_abnormal_cardiomyocyte_apopto0.67841339
111MP0008007_abnormal_cellular_replicative0.67732572
112MP0004130_abnormal_muscle_cell0.67680696
113MP0001286_abnormal_eye_development0.67405265
114MP0010352_gastrointestinal_tract_polyps0.66496789
115MP0005386_behavior/neurological_phenoty0.65843177
116MP0004924_abnormal_behavior0.65843177
117MP0000647_abnormal_sebaceous_gland0.65561820
118MP0005670_abnormal_white_adipose0.65132576
119MP0002084_abnormal_developmental_patter0.64971363
120MP0003638_abnormal_response/metabolism_0.64925952
121MP0001663_abnormal_digestive_system0.64798404
122MP0005535_abnormal_body_temperature0.63259186
123MP0000653_abnormal_sex_gland0.62999458
124MP0003698_abnormal_male_reproductive0.62446367
125MP0002060_abnormal_skin_morphology0.62327872
126MP0005409_darkened_coat_color0.62206892
127MP0003453_abnormal_keratinocyte_physiol0.62092316
128MP0005275_abnormal_skin_tensile0.62005373
129MP0003699_abnormal_female_reproductive0.61912023
130MP0004185_abnormal_adipocyte_glucose0.61654906
131MP0003567_abnormal_fetal_cardiomyocyte0.61134542
132MP0008961_abnormal_basal_metabolism0.60764303
133MP0003786_premature_aging0.59865872
134MP0006035_abnormal_mitochondrial_morpho0.59499601
135MP0009115_abnormal_fat_cell0.59433288
136MP0008469_abnormal_protein_level0.59420303
137MP0000467_abnormal_esophagus_morphology0.59412627
138MP0000579_abnormal_nail_morphology0.59158417
139MP0003045_fibrosis0.58506893
140MP0010155_abnormal_intestine_physiology0.58300542
141MP0002098_abnormal_vibrissa_morphology0.58255122
142MP0002210_abnormal_sex_determination0.57678093
143MP0005058_abnormal_lysosome_morphology0.57654295
144MP0005410_abnormal_fertilization0.57499220
145MP0005375_adipose_tissue_phenotype0.57308660
146MP0005376_homeostasis/metabolism_phenot0.56309576
147MP0005166_decreased_susceptibility_to0.54667756
148MP0001216_abnormal_epidermal_layer0.54502666
149MP0010368_abnormal_lymphatic_system0.53925169
150MP0003329_amyloid_beta_deposits0.53154838
151MP0005391_vision/eye_phenotype0.52693663
152MP0009763_increased_sensitivity_to0.52544215
153MP0005389_reproductive_system_phenotype0.52469146
154MP0004197_abnormal_fetal_growth/weight/0.52440274
155MP0002161_abnormal_fertility/fecundity0.52432426
156MP0003755_abnormal_palate_morphology0.52349321
157MP0003950_abnormal_plasma_membrane0.50821368
158MP0000427_abnormal_hair_cycle0.50302398
159MP0000477_abnormal_intestine_morphology0.49426788
160MP0005266_abnormal_metabolism0.49233466
161MP0000003_abnormal_adipose_tissue0.49052972
162MP0005377_hearing/vestibular/ear_phenot0.47559157
163MP0003878_abnormal_ear_physiology0.47559157
164MP0001191_abnormal_skin_condition0.46997815
165MP0006138_congestive_heart_failure0.45871481

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)6.29079080
2Abnormality of glutamine family amino acid metabolism (HP:0010902)5.99189528
3Xanthomatosis (HP:0000991)5.13700003
4Intrahepatic cholestasis (HP:0001406)5.02213951
5Acanthocytosis (HP:0001927)4.99142770
6Conjugated hyperbilirubinemia (HP:0002908)4.59867058
7Abnormality of proline metabolism (HP:0010907)4.49033091
8Hydroxyprolinuria (HP:0003080)4.49033091
9Hypolipoproteinemia (HP:0010981)4.38356171
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.34439467
11Ileus (HP:0002595)4.29543791
12Fat malabsorption (HP:0002630)4.18905007
13Hyperglycinuria (HP:0003108)4.04514776
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.98776418
15Epidermoid cyst (HP:0200040)3.86916335
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.82810853
17Deep venous thrombosis (HP:0002625)3.77192572
18Malnutrition (HP:0004395)3.76389437
19Abnormality of the vitamin B12 metabolism (HP:0004341)3.70538956
20Abnormality of vitamin B metabolism (HP:0004340)3.65938792
21Autoimmune thrombocytopenia (HP:0001973)3.62522194
22Abnormality of serine family amino acid metabolism (HP:0010894)3.59015915
23Abnormality of glycine metabolism (HP:0010895)3.59015915
24Renal cortical cysts (HP:0000803)3.47660111
25Hypoglycemic coma (HP:0001325)3.41738058
26Hypercholesterolemia (HP:0003124)3.36324482
27Volvulus (HP:0002580)3.31598796
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.31358986
29Abnormality of purine metabolism (HP:0004352)3.29045975
30Hyperammonemia (HP:0001987)3.25255355
31Right ventricular cardiomyopathy (HP:0011663)3.18211999
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.17579543
33Ketosis (HP:0001946)3.16764700
34Facial shape deformation (HP:0011334)3.13389238
35Potter facies (HP:0002009)3.13389238
36Ketoacidosis (HP:0001993)3.11256082
37Pigmentary retinal degeneration (HP:0001146)2.99859285
38Hypoalphalipoproteinemia (HP:0003233)2.94647800
39Abnormality of the common coagulation pathway (HP:0010990)2.93939472
40Widely patent fontanelles and sutures (HP:0004492)2.92269474
41Prolonged partial thromboplastin time (HP:0003645)2.85261956
42Poikilocytosis (HP:0004447)2.84398892
43Hypothermia (HP:0002045)2.80768596
44Hyperlipoproteinemia (HP:0010980)2.80123210
45Glycosuria (HP:0003076)2.71021336
46Abnormality of urine glucose concentration (HP:0011016)2.71021336
47Metabolic acidosis (HP:0001942)2.68370897
48Abnormality of nucleobase metabolism (HP:0010932)2.68326711
49Complement deficiency (HP:0004431)2.67471955
50Cupped ribs (HP:0000887)2.64284668
51Abnormality of glycolysis (HP:0004366)2.63199521
52Abnormality of fatty-acid metabolism (HP:0004359)2.57029258
53Medial flaring of the eyebrow (HP:0010747)2.56838508
54Increased serum pyruvate (HP:0003542)2.56716942
55Skin nodule (HP:0200036)2.56345020
56Autoimmune hemolytic anemia (HP:0001890)2.53363599
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.47059116
58Hyperbilirubinemia (HP:0002904)2.46357566
59Nephrolithiasis (HP:0000787)2.42351374
60Vascular calcification (HP:0004934)2.41594445
61Megaloblastic anemia (HP:0001889)2.39459007
62Increased IgE level (HP:0003212)2.37677173
63Abnormal tarsal ossification (HP:0008369)2.36845505
64Papillary thyroid carcinoma (HP:0002895)2.36275805
65Abnormality of the intrinsic pathway (HP:0010989)2.34972723
66Abdominal distention (HP:0003270)2.34924524
67Hypoglycemic seizures (HP:0002173)2.34318620
68Hypophosphatemic rickets (HP:0004912)2.33053940
69Dehydration (HP:0001944)2.32387771
70Congenital primary aphakia (HP:0007707)2.30879144
71Osteomalacia (HP:0002749)2.28886595
72Cardiovascular calcification (HP:0011915)2.27055210
73Colon cancer (HP:0003003)2.26608730
74Myocardial infarction (HP:0001658)2.26091079
75Hyperinsulinemic hypoglycemia (HP:0000825)2.25035661
76Polycythemia (HP:0001901)2.23181283
77Gout (HP:0001997)2.22535869
78Increased mean platelet volume (HP:0011877)2.22064202
79Cortical dysplasia (HP:0002539)2.18669532
80Generalized aminoaciduria (HP:0002909)2.17842581
81Symptomatic seizures (HP:0011145)2.17544925
82Proximal tubulopathy (HP:0000114)2.17298849
83Gait imbalance (HP:0002141)2.17245301
84Chromsome breakage (HP:0040012)2.13239827
85Pancreatitis (HP:0001733)2.13110265
86Amyloidosis (HP:0011034)2.12891203
87Abnormality of serum amino acid levels (HP:0003112)2.12330103
88Hyperglycinemia (HP:0002154)2.11092920
89Sensorimotor neuropathy (HP:0007141)2.10212735
90Cholecystitis (HP:0001082)2.08782380
91Abnormal gallbladder physiology (HP:0012438)2.08782380
92Abnormality of the renal cortex (HP:0011035)2.06899108
93Systemic lupus erythematosus (HP:0002725)2.02440451
94Poor coordination (HP:0002370)2.01825119
95Chorioretinal atrophy (HP:0000533)2.00544093
96Nephrogenic diabetes insipidus (HP:0009806)1.99076086
97Reticulocytosis (HP:0001923)1.98767787
98Abnormality of chromosome stability (HP:0003220)1.98466012
99Abnormality of vitamin metabolism (HP:0100508)1.97780956
100Hypophosphatemia (HP:0002148)1.96849668
101Joint hemorrhage (HP:0005261)1.94825517
102Abnormal gallbladder morphology (HP:0012437)1.93002200
103Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92749820
104Confusion (HP:0001289)1.92391666
105Protuberant abdomen (HP:0001538)1.91851390
106Abnormal urine phosphate concentration (HP:0012599)1.90257565
107Hepatocellular carcinoma (HP:0001402)1.89310335
108Late onset (HP:0003584)1.89006048
109Esophageal varix (HP:0002040)1.87536375
110Hyperglycemia (HP:0003074)1.86447041
111Abnormal platelet volume (HP:0011876)1.85878828
112Peripheral demyelination (HP:0011096)1.85437705
113Steatorrhea (HP:0002570)1.84605487
114Hyperuricemia (HP:0002149)1.84413041
115Increased purine levels (HP:0004368)1.84413041
116Abnormal glucose tolerance (HP:0001952)1.83791443
117Cholelithiasis (HP:0001081)1.83519860
118Thyroid carcinoma (HP:0002890)1.83236581
119Genital tract atresia (HP:0001827)1.82936095
120Rickets (HP:0002748)1.82349937
121Abnormality of complement system (HP:0005339)1.82261463
122Vaginal atresia (HP:0000148)1.81837310
123Hyperphosphaturia (HP:0003109)1.80952506
124Dicarboxylic aciduria (HP:0003215)1.79981185
125Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79981185
126Chronic diarrhea (HP:0002028)1.78410844
127Termporal pattern (HP:0011008)1.75787505
128Insidious onset (HP:0003587)1.75787505
129Biliary tract neoplasm (HP:0100574)1.75068702
130Alkalosis (HP:0001948)1.75064985
131Broad alveolar ridges (HP:0000187)1.73498022
132Mesangial abnormality (HP:0001966)1.73228748
133Urethral obstruction (HP:0000796)1.72239173
134Meckel diverticulum (HP:0002245)1.72040448
135Irritability (HP:0000737)1.72017544
136Abnormal foot bone ossification (HP:0010675)1.67469190
137Abnormal biliary tract morphology (HP:0012440)1.66853947
138Methylmalonic aciduria (HP:0012120)1.66103892
139Abnormality of the labia minora (HP:0012880)1.65378392
140Abnormality of the ileum (HP:0001549)1.65089421
141Posterior subcapsular cataract (HP:0007787)1.63887378
142Neoplasm of the small intestine (HP:0100833)1.63725428
143Medulloblastoma (HP:0002885)1.63105784
144Neuroendocrine neoplasm (HP:0100634)1.61622842
145Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.58687331
146Abnormality of alanine metabolism (HP:0010916)1.58687331
147Hyperalaninemia (HP:0003348)1.58687331
148Pheochromocytoma (HP:0002666)1.57624426
149Lethargy (HP:0001254)1.57023476
150Methylmalonic acidemia (HP:0002912)1.56475236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK15.85538729
2FRK4.83530389
3ACVR1B3.98999613
4MST1R3.60548876
5ERN12.93936664
6MST42.90277355
7RIPK12.86042383
8TAOK32.64391984
9INSRR2.55370417
10TRIM282.47793511
11LMTK22.47456343
12PLK42.39210522
13LATS12.38865566
14BCR2.24313770
15PTK62.20147537
16BUB12.18814758
17EPHB12.18472456
18SIK12.17815354
19EIF2AK32.13973815
20MAP3K22.04033250
21BRSK22.02981953
22PRKG22.00189394
23TTK1.98914949
24ERBB31.98755337
25SRPK11.96905375
26NEK21.93826399
27MAP3K41.93373553
28BCKDK1.89108367
29MAP4K21.80604518
30FGFR41.79728765
31TSSK61.79555773
32BMPR1B1.78109944
33WNK41.74487307
34AKT31.71921685
35GRK61.66578517
36MET1.66565005
37MAP3K101.63886940
38CDC71.60305835
39MKNK21.59607653
40STK391.55512613
41EPHA21.52185003
42EIF2AK11.50941553
43MAP2K71.49847622
44NUAK11.47877202
45MAP3K71.41151049
46TNIK1.38590775
47FGFR21.31507968
48PLK31.28536082
49OXSR11.27978211
50TRIB31.26611694
51BRD41.23576266
52PRKAA21.20421689
53EPHA41.15503271
54TBK11.13157180
55MKNK11.12131714
56CSNK1G11.11602154
57CASK1.10029144
58FER1.09737998
59PINK11.06063915
60PKN21.05460180
61MAP2K21.02990610
62PIK3CG1.01849163
63PLK11.00329988
64ERBB40.99607644
65CSNK1A1L0.96704956
66MAPK150.95283704
67CAMK1D0.94267123
68STK38L0.92690876
69PTK20.92502027
70DDR20.92410852
71ZAK0.92082497
72BMX0.88664641
73GRK10.87688031
74JAK10.87187409
75PDPK10.85843214
76TAOK10.85484038
77CSNK1G30.84878451
78FGFR10.84750746
79PAK30.82211955
80MAP3K10.81508832
81TIE10.81170363
82NME10.80181068
83PDGFRA0.79727884
84TYK20.78907981
85WNK10.77255614
86ATM0.77229074
87MAP3K30.76546467
88MAPK110.74730743
89EPHA30.74694046
90DMPK0.72997477
91PLK20.72852006
92LRRK20.70601207
93STK240.69329078
94PIK3CA0.68510149
95FGFR30.68383588
96PRKD10.67921091
97STK30.67826129
98MAP3K120.67673322
99JAK20.67385527
100CSNK1G20.66041575
101ERBB20.65649935
102TGFBR20.65625157
103PRKAA10.65420589
104BRSK10.63453533
105GSK3A0.63157303
106STK100.62084335
107PDK20.61601185
108NEK60.61362411
109WEE10.61259533
110RET0.60493537
111MAPK130.60268849
112NEK90.59509896
113ATR0.59003137
114MAP2K40.58686727
115CAMK1G0.57281607
116SGK30.57086929
117KSR20.54780266
118EPHB20.54586085
119AURKB0.54494216
120PRKCH0.54439242
121CSNK1E0.54408285
122PRKCE0.54368125
123PDK10.52914404
124MATK0.52080845
125IRAK30.51938344
126MAP2K10.51890216
127MAP3K140.51452980
128MARK10.50717426
129DYRK1B0.50491378
130PRKCQ0.50313509
131PRKCG0.49028997
132CSK0.46346839
133CDK80.46181280
134SCYL20.45976562
135CHEK20.44182490
136PRKACG0.42953367
137TESK20.42816166
138MYLK0.41799125
139PDGFRB0.40677506
140OBSCN0.40578303
141PRKACB0.40188577
142CAMK2A0.40014435
143KDR0.38906897
144CHEK10.38685551
145PDK30.38431549
146PDK40.38431549
147NTRK10.38425920
148WNK30.37669536
149RIPK40.37351981
150PAK20.36105030
151IKBKE0.35774470
152FLT30.35490698
153CDK10.35202445
154CCNB10.34522738
155CSNK1D0.33002803
156CDK30.32993707
157ITK0.32976358
158MAPKAPK50.32667882
159PBK0.32133966
160IGF1R0.31962716
161CAMKK20.31928726
162CDK60.30791521
163DYRK30.30493097
164EIF2AK20.29697414
165CSNK2A20.29381152
166CDK70.28330027
167MAPKAPK30.28257583
168CAMK2B0.27817554

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.91613309
2Nitrogen metabolism_Homo sapiens_hsa009102.88801385
3Vitamin digestion and absorption_Homo sapiens_hsa049772.81849003
4Caffeine metabolism_Homo sapiens_hsa002322.63469639
5Renin-angiotensin system_Homo sapiens_hsa046142.55921110
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.53963655
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.46988067
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.33885751
9Arginine biosynthesis_Homo sapiens_hsa002202.28637161
10Starch and sucrose metabolism_Homo sapiens_hsa005002.27987953
11Tryptophan metabolism_Homo sapiens_hsa003802.22704606
12Fatty acid degradation_Homo sapiens_hsa000712.16690327
13Histidine metabolism_Homo sapiens_hsa003402.04396979
14PPAR signaling pathway_Homo sapiens_hsa033202.03749094
15Bile secretion_Homo sapiens_hsa049761.97164744
16Mineral absorption_Homo sapiens_hsa049781.97014667
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.88195121
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79641407
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78920827
20Sulfur metabolism_Homo sapiens_hsa009201.77881077
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75002671
22Folate biosynthesis_Homo sapiens_hsa007901.74031609
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.71895733
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67848935
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65336663
26Butanoate metabolism_Homo sapiens_hsa006501.59052159
27Galactose metabolism_Homo sapiens_hsa000521.57913871
28Fatty acid metabolism_Homo sapiens_hsa012121.55284349
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54984908
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54787837
31Non-homologous end-joining_Homo sapiens_hsa034501.53334722
32Propanoate metabolism_Homo sapiens_hsa006401.46983651
33Peroxisome_Homo sapiens_hsa041461.46613999
34ABC transporters_Homo sapiens_hsa020101.44887013
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40119334
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37987590
37Protein digestion and absorption_Homo sapiens_hsa049741.37006702
38beta-Alanine metabolism_Homo sapiens_hsa004101.34702569
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.29093932
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26765242
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24184034
42Chemical carcinogenesis_Homo sapiens_hsa052041.23247843
43Pyruvate metabolism_Homo sapiens_hsa006201.19682496
44Glycerolipid metabolism_Homo sapiens_hsa005611.19255835
45Protein export_Homo sapiens_hsa030601.19055533
46Complement and coagulation cascades_Homo sapiens_hsa046101.18866135
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16232139
48Fatty acid elongation_Homo sapiens_hsa000621.14421237
49Retinol metabolism_Homo sapiens_hsa008301.12411243
50Basal transcription factors_Homo sapiens_hsa030221.09136511
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08868467
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.08366782
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99606195
54Mismatch repair_Homo sapiens_hsa034300.98425496
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97132198
56Arginine and proline metabolism_Homo sapiens_hsa003300.97115269
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96260658
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95067556
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.94448350
60Steroid biosynthesis_Homo sapiens_hsa001000.94309894
61Glutathione metabolism_Homo sapiens_hsa004800.92535115
62Phenylalanine metabolism_Homo sapiens_hsa003600.90092628
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88076569
64Homologous recombination_Homo sapiens_hsa034400.87856828
65Carbon metabolism_Homo sapiens_hsa012000.85059106
66Fanconi anemia pathway_Homo sapiens_hsa034600.82888750
67Fatty acid biosynthesis_Homo sapiens_hsa000610.79816211
68RNA degradation_Homo sapiens_hsa030180.76895628
69Selenocompound metabolism_Homo sapiens_hsa004500.75878429
70RNA transport_Homo sapiens_hsa030130.75195762
71Fructose and mannose metabolism_Homo sapiens_hsa000510.74737589
72Staphylococcus aureus infection_Homo sapiens_hsa051500.74327005
73Lysine degradation_Homo sapiens_hsa003100.74172307
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71268150
75Tyrosine metabolism_Homo sapiens_hsa003500.69877874
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68039741
77Proteasome_Homo sapiens_hsa030500.68004953
78One carbon pool by folate_Homo sapiens_hsa006700.61921782
79Circadian rhythm_Homo sapiens_hsa047100.54438731
80Biosynthesis of amino acids_Homo sapiens_hsa012300.54339570
81Cell cycle_Homo sapiens_hsa041100.53869180
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53505671
83Insulin resistance_Homo sapiens_hsa049310.48756223
84RNA polymerase_Homo sapiens_hsa030200.46701659
85Nucleotide excision repair_Homo sapiens_hsa034200.45349784
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44682481
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.44635201
88Oocyte meiosis_Homo sapiens_hsa041140.44229318
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44202911
90Type II diabetes mellitus_Homo sapiens_hsa049300.42444214
91Nicotine addiction_Homo sapiens_hsa050330.40180527
92N-Glycan biosynthesis_Homo sapiens_hsa005100.39658052
93* Sphingolipid metabolism_Homo sapiens_hsa006000.38671222
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.36055922
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34626283
96Thyroid hormone synthesis_Homo sapiens_hsa049180.34568771
97Linoleic acid metabolism_Homo sapiens_hsa005910.32793089
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32506478
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32137449
100* Metabolic pathways_Homo sapiens_hsa011000.26186113
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.25475918
102Pentose phosphate pathway_Homo sapiens_hsa000300.25412780
103Pancreatic secretion_Homo sapiens_hsa049720.23017666
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19173306
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19043746
106Ether lipid metabolism_Homo sapiens_hsa005650.17199556
107African trypanosomiasis_Homo sapiens_hsa051430.13918429
108AMPK signaling pathway_Homo sapiens_hsa041520.13449078
109Arachidonic acid metabolism_Homo sapiens_hsa005900.13276173
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.10595741
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10518661
112Tight junction_Homo sapiens_hsa045300.09630330
113Hepatitis C_Homo sapiens_hsa051600.09542517
114Amoebiasis_Homo sapiens_hsa051460.08055728
115Ovarian steroidogenesis_Homo sapiens_hsa049130.07940761
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06214561
117Renin secretion_Homo sapiens_hsa049240.06059463
118Insulin secretion_Homo sapiens_hsa049110.04558174
119Glucagon signaling pathway_Homo sapiens_hsa049220.03875654
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03566662
121Gastric acid secretion_Homo sapiens_hsa049710.03502510
122Vitamin B6 metabolism_Homo sapiens_hsa007500.00071975

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