ARX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is thought to be involved in CNS development. Expansion of a polyalanine tract and other mutations in this gene cause X-linked mental retardation and epilepsy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of oligodendrocyte differentiation (GO:0048715)5.59657421
2gamma-aminobutyric acid transport (GO:0015812)5.50741569
3neuron cell-cell adhesion (GO:0007158)5.38555259
4pyrimidine dimer repair (GO:0006290)5.25990376
5glycine transport (GO:0015816)5.02847671
6pyrimidine nucleobase catabolic process (GO:0006208)4.93772338
7layer formation in cerebral cortex (GO:0021819)4.91432288
8vocalization behavior (GO:0071625)4.87887313
9limb bud formation (GO:0060174)4.49891273
10neuron recognition (GO:0008038)4.44878515
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.38178797
12dendritic spine morphogenesis (GO:0060997)4.37851788
13protein localization to synapse (GO:0035418)4.33807435
14glial cell proliferation (GO:0014009)4.23078132
15cell migration in hindbrain (GO:0021535)4.20287917
16regulation of glutamate receptor signaling pathway (GO:1900449)4.10026005
17cerebral cortex radially oriented cell migration (GO:0021799)4.07946488
18synaptic vesicle exocytosis (GO:0016079)4.06461557
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.03044848
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.00960810
21central nervous system projection neuron axonogenesis (GO:0021952)3.99196465
22hippocampus development (GO:0021766)3.98909380
23nucleobase catabolic process (GO:0046113)3.96850465
24axonal fasciculation (GO:0007413)3.96699453
25positive regulation of synaptic transmission, GABAergic (GO:0032230)3.96308439
26lens morphogenesis in camera-type eye (GO:0002089)3.95958997
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.94561565
28neuron fate determination (GO:0048664)3.89847503
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.76267075
30neurotransmitter secretion (GO:0007269)3.75345229
31presynaptic membrane organization (GO:0097090)3.75299117
32regulation of synaptic vesicle exocytosis (GO:2000300)3.73052746
33positive regulation of synapse maturation (GO:0090129)3.71290922
34locomotory exploration behavior (GO:0035641)3.70825375
35positive regulation of synapse assembly (GO:0051965)3.60844838
36behavioral response to nicotine (GO:0035095)3.59065378
37nonmotile primary cilium assembly (GO:0035058)3.57624542
38synaptic vesicle maturation (GO:0016188)3.55822478
39glutamate secretion (GO:0014047)3.55772919
40multicellular organismal aging (GO:0010259)3.53179137
41forebrain neuron differentiation (GO:0021879)3.49236344
42dendrite morphogenesis (GO:0048813)3.48634328
43postsynaptic membrane organization (GO:0001941)3.47143108
44response to auditory stimulus (GO:0010996)3.45407462
45regulation of timing of cell differentiation (GO:0048505)3.42994512
46forebrain neuron development (GO:0021884)3.39123541
47auditory behavior (GO:0031223)3.36823702
48regulation of development, heterochronic (GO:0040034)3.34174779
49gonadal mesoderm development (GO:0007506)3.32540356
50negative regulation of multicellular organism growth (GO:0040015)3.30547169
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30121373
52proline transport (GO:0015824)3.27779966
53regulation of synaptic vesicle transport (GO:1902803)3.27119999
54central nervous system neuron development (GO:0021954)3.26710659
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.26364968
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25902758
57protein localization to cilium (GO:0061512)3.25499229
58synaptic transmission, glutamatergic (GO:0035249)3.23741135
59protein polyglutamylation (GO:0018095)3.22728448
60regulation of transcription involved in cell fate commitment (GO:0060850)3.21438966
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20984369
62regulation of vesicle fusion (GO:0031338)3.18674162
63positive regulation of amino acid transport (GO:0051957)3.16522786
64hindbrain development (GO:0030902)3.14730223
65spinal cord development (GO:0021510)3.13011680
66exploration behavior (GO:0035640)3.12726858
67central nervous system neuron axonogenesis (GO:0021955)3.12036509
68negative regulation of cytosolic calcium ion concentration (GO:0051481)3.11254929
69regulation of neuronal synaptic plasticity (GO:0048168)3.10455354
70regulation of cilium movement (GO:0003352)3.09727286
71negative regulation of glial cell differentiation (GO:0045686)3.08155911
72artery development (GO:0060840)3.07731574
73embryonic foregut morphogenesis (GO:0048617)3.06829013
74astrocyte differentiation (GO:0048708)3.05788268
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05562004
76regulation of oligodendrocyte differentiation (GO:0048713)3.04709591
77mechanosensory behavior (GO:0007638)3.04635762
78regulation of synapse maturation (GO:0090128)3.04389225
79spinal cord motor neuron differentiation (GO:0021522)3.04389111
80neuronal action potential propagation (GO:0019227)3.04316539
81regulation of synapse structural plasticity (GO:0051823)3.04124326
82epithelial cilium movement (GO:0003351)3.03886758
83regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03708736
84intraciliary transport (GO:0042073)3.03162902
85regulation of synapse assembly (GO:0051963)3.01967867
86olfactory bulb development (GO:0021772)3.00071450
87regulation of dendritic spine morphogenesis (GO:0061001)2.99383726
88glutamate receptor signaling pathway (GO:0007215)2.99223747
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99098625
90positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98182450
91retinal ganglion cell axon guidance (GO:0031290)2.97046257
92cerebellum development (GO:0021549)2.94973159
93glycosphingolipid biosynthetic process (GO:0006688)2.94583034
94protein-cofactor linkage (GO:0018065)2.94436101
95neurotransmitter-gated ion channel clustering (GO:0072578)2.90517782
96negative regulation of telomere maintenance (GO:0032205)2.88609757
97somite development (GO:0061053)2.87767698
98regulation of hexokinase activity (GO:1903299)2.87423081
99regulation of glucokinase activity (GO:0033131)2.87423081
100positive regulation of oligodendrocyte differentiation (GO:0048714)2.86782306
101cornea development in camera-type eye (GO:0061303)2.86243812
102presynaptic membrane assembly (GO:0097105)2.85428578
103synapse assembly (GO:0007416)2.83591946
104regulation of synaptic transmission, GABAergic (GO:0032228)2.83437098
105cerebral cortex neuron differentiation (GO:0021895)2.83268481
106synaptic vesicle docking involved in exocytosis (GO:0016081)2.82164356
107positive regulation of dendritic spine development (GO:0060999)2.82150598
108neuron-neuron synaptic transmission (GO:0007270)2.81379030
109cellular ketone body metabolic process (GO:0046950)2.81011227
110long-term memory (GO:0007616)2.80885849
111adult feeding behavior (GO:0008343)2.80125330
112axoneme assembly (GO:0035082)2.79651204
113G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.79371692
114neurotransmitter transport (GO:0006836)2.78308465
115glycerophospholipid catabolic process (GO:0046475)2.77482438
116* neuron migration (GO:0001764)2.75133098
117regulation of respiratory system process (GO:0044065)2.74247597
118dentate gyrus development (GO:0021542)2.72634459
119cilium assembly (GO:0042384)2.72103732
120negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71611697
121cilium organization (GO:0044782)2.71031708
122cardiac ventricle formation (GO:0003211)2.68907690
123alanine transport (GO:0032328)2.68785138
124regulation of synapse organization (GO:0050807)2.68582200
125proximal/distal pattern formation (GO:0009954)2.68257868
126gamma-aminobutyric acid signaling pathway (GO:0007214)2.68177053
127neuron fate specification (GO:0048665)2.67727449
128neuronal ion channel clustering (GO:0045161)2.67340124
129kidney morphogenesis (GO:0060993)2.66182248
130negative regulation of gliogenesis (GO:0014014)2.65516005
131atrial cardiac muscle cell action potential (GO:0086014)2.65238262
132cochlea development (GO:0090102)2.64702499
133regulation of neuron migration (GO:2001222)2.64571894
134neural tube formation (GO:0001841)2.62688232
135protein complex biogenesis (GO:0070271)2.62143071
136positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.61486043
137water-soluble vitamin biosynthetic process (GO:0042364)2.60830297
138inositol phosphate catabolic process (GO:0071545)2.60240407
139startle response (GO:0001964)2.59389254
140cilium movement (GO:0003341)2.58203998
141cilium morphogenesis (GO:0060271)2.55757103
142cAMP catabolic process (GO:0006198)2.54620936
143nephron epithelium morphogenesis (GO:0072088)2.54364329
144nephron tubule morphogenesis (GO:0072078)2.54364329
145ubiquinone metabolic process (GO:0006743)2.52332927
146positive regulation of gastrulation (GO:2000543)2.51925293
147calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.48814625
148membrane depolarization during action potential (GO:0086010)2.48726661
149urinary tract smooth muscle contraction (GO:0014848)2.47847182
150ketone body metabolic process (GO:1902224)2.47257938
151transmission of nerve impulse (GO:0019226)2.46015670
152response to pheromone (GO:0019236)2.45807031
153smoothened signaling pathway (GO:0007224)2.44122239
154reflex (GO:0060004)2.41622014
155negative regulation of astrocyte differentiation (GO:0048712)2.40872471
156dopamine transport (GO:0015872)2.40558781
157fucose catabolic process (GO:0019317)2.40143726
158L-fucose metabolic process (GO:0042354)2.40143726
159L-fucose catabolic process (GO:0042355)2.40143726
160renal tubule morphogenesis (GO:0061333)2.40074557
161cyclic nucleotide catabolic process (GO:0009214)2.39177575
162negative regulation of appetite (GO:0032099)2.37801112
163negative regulation of response to food (GO:0032096)2.37801112
164establishment of mitochondrion localization (GO:0051654)2.37119858
165regulation of membrane repolarization (GO:0060306)2.36240016
166neuromuscular synaptic transmission (GO:0007274)2.34544486
167mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.34361042
168insulin secretion (GO:0030073)2.33811090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.52054458
2* EZH2_27304074_Chip-Seq_ESCs_Mouse3.37440434
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.31353865
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07652229
5GBX2_23144817_ChIP-Seq_PC3_Human2.98549081
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97418496
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.88633420
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.88633420
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77502901
10* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.73804992
11* EZH2_27294783_Chip-Seq_ESCs_Mouse2.71714670
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.68400876
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.59893637
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58438968
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.55716105
16* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.55435811
17* RNF2_27304074_Chip-Seq_ESCs_Mouse2.51202052
18REST_21632747_ChIP-Seq_MESCs_Mouse2.48118369
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46115262
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39025187
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34226367
22* CBX2_27304074_Chip-Seq_ESCs_Mouse2.30798699
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28878824
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24971910
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.05912660
26VDR_22108803_ChIP-Seq_LS180_Human2.03293368
27* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.01808291
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.00179346
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94667531
30DROSHA_22980978_ChIP-Seq_HELA_Human1.89201593
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88907460
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88689348
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78042704
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75885164
35* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72879058
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67088599
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.66065389
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65847067
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.62241352
40EWS_26573619_Chip-Seq_HEK293_Human1.59954494
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.58998632
42AR_21572438_ChIP-Seq_LNCaP_Human1.58489524
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58211555
44* RNF2_27304074_Chip-Seq_NSC_Mouse1.58175447
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57975835
46* RING1B_27294783_Chip-Seq_ESCs_Mouse1.53990385
47* RING1B_27294783_Chip-Seq_NPCs_Mouse1.53702214
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53164175
49ER_23166858_ChIP-Seq_MCF-7_Human1.50536412
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49867175
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48255874
52BCAT_22108803_ChIP-Seq_LS180_Human1.47356452
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46815608
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41916829
55* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41571014
56* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38766771
57P300_19829295_ChIP-Seq_ESCs_Human1.37993302
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37869357
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36795093
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34195647
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33633776
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31948421
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31134925
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29191832
65CBP_20019798_ChIP-Seq_JUKART_Human1.28865006
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28865006
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.28575166
68IGF1R_20145208_ChIP-Seq_DFB_Human1.27479960
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26824807
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26220525
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.24960653
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24606365
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.24491549
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24005555
75SMAD4_21799915_ChIP-Seq_A2780_Human1.22982132
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22843386
77* TP53_20018659_ChIP-ChIP_R1E_Mouse1.22745480
78TP53_22573176_ChIP-Seq_HFKS_Human1.21614860
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20558703
80* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19810989
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19209226
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19180042
83TAF15_26573619_Chip-Seq_HEK293_Human1.17727176
84HTT_18923047_ChIP-ChIP_STHdh_Human1.15059546
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14888934
86ZNF274_21170338_ChIP-Seq_K562_Hela1.14471235
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12869458
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12583731
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11626144
90P53_22387025_ChIP-Seq_ESCs_Mouse1.11609711
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11166050
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11113355
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10978016
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10806085
95* AR_19668381_ChIP-Seq_PC3_Human1.09131047
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.06403029
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06287745
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.05785279
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.05702792
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05683811
101TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05347897
102AR_25329375_ChIP-Seq_VCAP_Human1.05254138
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04361935
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04208119
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04192624
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04086897
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03818656
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02739622
109CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02418960
110DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02125261
111NANOG_19829295_ChIP-Seq_ESCs_Human1.01731714
112SOX2_19829295_ChIP-Seq_ESCs_Human1.01731714
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01490385
114EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01282274
115* TCF4_22108803_ChIP-Seq_LS180_Human1.00868290
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98686691
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97050841
118* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96723329
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95507848
120* ISL1_27105846_Chip-Seq_CPCs_Mouse0.95296066
121ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94877469
122FUS_26573619_Chip-Seq_HEK293_Human0.94860153
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.92714025
124NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92680347
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92634226
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92622066
127SOX2_16153702_ChIP-ChIP_HESCs_Human0.92465419
128STAT3_23295773_ChIP-Seq_U87_Human0.92030109
129KDM2B_26808549_Chip-Seq_K562_Human0.92027182
130RUNX2_22187159_ChIP-Seq_PCA_Human0.91860033
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.91717593
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90438148
133TCF4_23295773_ChIP-Seq_U87_Human0.89567271
134* SMAD4_21741376_ChIP-Seq_HESCs_Human0.88878584
135RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88605531
136* SMAD3_21741376_ChIP-Seq_HESCs_Human0.88560255
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.88135653
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87253764
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87253764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.02177152
2MP0003635_abnormal_synaptic_transmissio2.95628795
3MP0006292_abnormal_olfactory_placode2.83870639
4MP0000778_abnormal_nervous_system2.73044824
5MP0004270_analgesia2.64009516
6MP0000013_abnormal_adipose_tissue2.49041090
7MP0002837_dystrophic_cardiac_calcinosis2.47172462
8* MP0002063_abnormal_learning/memory/cond2.40731210
9* MP0002064_seizures2.32316175
10* MP0009745_abnormal_behavioral_response2.25949946
11MP0003880_abnormal_central_pattern2.21807121
12MP0002638_abnormal_pupillary_reflex2.16691168
13MP0005394_taste/olfaction_phenotype2.13495145
14MP0005499_abnormal_olfactory_system2.13495145
15MP0002249_abnormal_larynx_morphology2.13348745
16MP0008789_abnormal_olfactory_epithelium2.11416865
17* MP0002572_abnormal_emotion/affect_behav2.09549490
18MP0000537_abnormal_urethra_morphology2.08346716
19MP0000516_abnormal_urinary_system2.06698757
20MP0005367_renal/urinary_system_phenotyp2.06698757
21MP0001486_abnormal_startle_reflex2.05168472
22MP0002184_abnormal_innervation2.03520597
23MP0004142_abnormal_muscle_tone2.03095559
24MP0005423_abnormal_somatic_nervous1.98436059
25* MP0002557_abnormal_social/conspecific_i1.93163322
26MP0002734_abnormal_mechanical_nocicepti1.92611486
27* MP0009046_muscle_twitch1.90296284
28MP0005645_abnormal_hypothalamus_physiol1.90104128
29MP0004043_abnormal_pH_regulation1.83451937
30MP0000049_abnormal_middle_ear1.83348388
31MP0009780_abnormal_chondrocyte_physiolo1.83139762
32MP0008877_abnormal_DNA_methylation1.82678484
33MP0004885_abnormal_endolymph1.80358776
34MP0003787_abnormal_imprinting1.80014928
35MP0002938_white_spotting1.78937228
36MP0006276_abnormal_autonomic_nervous1.72530556
37MP0002735_abnormal_chemical_nociception1.72461326
38MP0000955_abnormal_spinal_cord1.70343675
39* MP0002272_abnormal_nervous_system1.68997660
40MP0001529_abnormal_vocalization1.67261197
41MP0001502_abnormal_circadian_rhythm1.66682968
42MP0004858_abnormal_nervous_system1.65955340
43MP0004133_heterotaxia1.60656626
44* MP0004811_abnormal_neuron_physiology1.59177169
45MP0005551_abnormal_eye_electrophysiolog1.57774709
46MP0005257_abnormal_intraocular_pressure1.56472783
47MP0001968_abnormal_touch/_nociception1.54636319
48MP0003011_delayed_dark_adaptation1.53250580
49MP0003122_maternal_imprinting1.52497938
50MP0008569_lethality_at_weaning1.49982125
51MP0002102_abnormal_ear_morphology1.48967804
52MP0005379_endocrine/exocrine_gland_phen1.47331832
53* MP0002733_abnormal_thermal_nociception1.47266819
54MP0003938_abnormal_ear_development1.46292158
55MP0000631_abnormal_neuroendocrine_gland1.45700537
56MP0010386_abnormal_urinary_bladder1.43143396
57MP0005084_abnormal_gallbladder_morpholo1.42606148
58MP0005253_abnormal_eye_physiology1.39990041
59MP0002067_abnormal_sensory_capabilities1.36670464
60* MP0002882_abnormal_neuron_morphology1.36533838
61MP0002653_abnormal_ependyma_morphology1.35140275
62MP0002234_abnormal_pharynx_morphology1.33493453
63MP0001270_distended_abdomen1.32577886
64* MP0002152_abnormal_brain_morphology1.32039491
65MP0005646_abnormal_pituitary_gland1.31914451
66MP0001984_abnormal_olfaction1.31101818
67* MP0001970_abnormal_pain_threshold1.30246927
68MP0002909_abnormal_adrenal_gland1.28591540
69MP0001501_abnormal_sleep_pattern1.28008392
70MP0003890_abnormal_embryonic-extraembry1.27359134
71MP0005386_behavior/neurological_phenoty1.27252464
72MP0004924_abnormal_behavior1.27252464
73* MP0003861_abnormal_nervous_system1.24062566
74MP0002736_abnormal_nociception_after1.23171471
75MP0004145_abnormal_muscle_electrophysio1.22415003
76MP0002751_abnormal_autonomic_nervous1.22049795
77MP0002876_abnormal_thyroid_physiology1.21252428
78* MP0002066_abnormal_motor_capabilities/c1.15717602
79* MP0001944_abnormal_pancreas_morphology1.13088058
80MP0010030_abnormal_orbit_morphology1.12267026
81MP0001440_abnormal_grooming_behavior1.11182106
82MP0001188_hyperpigmentation1.10350801
83MP0004742_abnormal_vestibular_system1.10210855
84MP0003385_abnormal_body_wall1.09660284
85MP0003119_abnormal_digestive_system1.08206047
86MP0002163_abnormal_gland_morphology1.07431954
87MP0001485_abnormal_pinna_reflex1.07381228
88MP0003755_abnormal_palate_morphology1.07342013
89MP0003183_abnormal_peptide_metabolism1.05034328
90MP0002277_abnormal_respiratory_mucosa1.02937262
91MP0002822_catalepsy1.02894686
92MP0000566_synostosis1.01791136
93MP0009384_cardiac_valve_regurgitation1.01106808
94MP0002069_abnormal_eating/drinking_beha0.99462546
95MP0003136_yellow_coat_color0.97530127
96MP0000427_abnormal_hair_cycle0.97500222
97MP0002116_abnormal_craniofacial_bone0.97057443
98MP0002693_abnormal_pancreas_physiology0.94970299
99MP0005187_abnormal_penis_morphology0.91867121
100MP0005195_abnormal_posterior_eye0.91792794
101MP0000026_abnormal_inner_ear0.91532869
102MP0003121_genomic_imprinting0.90537446
103MP0002752_abnormal_somatic_nervous0.89972399
104MP0000383_abnormal_hair_follicle0.88831669
105MP0002233_abnormal_nose_morphology0.88485587
106MP0006072_abnormal_retinal_apoptosis0.88385484
107MP0003315_abnormal_perineum_morphology0.88295577
108MP0003935_abnormal_craniofacial_develop0.87530146
109MP0003634_abnormal_glial_cell0.87352404
110MP0004215_abnormal_myocardial_fiber0.86208770
111MP0003283_abnormal_digestive_organ0.85006798
112MP0000003_abnormal_adipose_tissue0.84109939
113MP0003633_abnormal_nervous_system0.83776938
114MP0003937_abnormal_limbs/digits/tail_de0.81249615
115MP0003115_abnormal_respiratory_system0.81027396
116MP0001963_abnormal_hearing_physiology0.80912190
117MP0001986_abnormal_taste_sensitivity0.80865084
118MP0001943_abnormal_respiration0.76430645
119* MP0002081_perinatal_lethality0.76081827
120* MP0002082_postnatal_lethality0.73309574
121* MP0010770_preweaning_lethality0.73309574
122MP0004085_abnormal_heartbeat0.72619400
123MP0001905_abnormal_dopamine_level0.72500178
124MP0002177_abnormal_outer_ear0.72444795
125MP0005248_abnormal_Harderian_gland0.69968840
126MP0001664_abnormal_digestion0.69941385

Predicted human phenotypes

RankGene SetZ-score
1Morphological abnormality of the middle ear (HP:0008609)6.12540377
2Failure to thrive in infancy (HP:0001531)5.01810872
3Hyperacusis (HP:0010780)4.60362754
4Focal motor seizures (HP:0011153)4.58881540
5Abnormality of the aortic arch (HP:0012303)4.55855293
6Bilateral microphthalmos (HP:0007633)4.40442892
7Tented upper lip vermilion (HP:0010804)4.39099623
8Prominent metopic ridge (HP:0005487)3.88408956
9Abnormality of the metopic suture (HP:0005556)3.84968087
10Broad face (HP:0000283)3.79130758
11Pancreatic fibrosis (HP:0100732)3.45131567
12Epileptic encephalopathy (HP:0200134)3.39883993
13Abnormality of midbrain morphology (HP:0002418)3.27213474
14Molar tooth sign on MRI (HP:0002419)3.27213474
15True hermaphroditism (HP:0010459)3.25416070
16Pancreatic cysts (HP:0001737)3.23213345
17Intestinal atresia (HP:0011100)3.21002846
18Myokymia (HP:0002411)3.18861734
19Nephronophthisis (HP:0000090)3.15655845
20Focal seizures (HP:0007359)3.12968287
21Megalencephaly (HP:0001355)3.11994208
22Hyperventilation (HP:0002883)3.08934669
23Type II lissencephaly (HP:0007260)3.05844428
24Abnormality of the labia minora (HP:0012880)3.05491474
25Abnormality of chromosome segregation (HP:0002916)3.03715975
26Excessive salivation (HP:0003781)2.87344988
27Drooling (HP:0002307)2.87344988
28Hemiparesis (HP:0001269)2.85102904
29Progressive cerebellar ataxia (HP:0002073)2.77814876
30Abnormal rod and cone electroretinograms (HP:0008323)2.77525180
31Split foot (HP:0001839)2.77112637
32Hyperthyroidism (HP:0000836)2.71375565
33Abnormality of the renal medulla (HP:0100957)2.69472680
34Stereotypic behavior (HP:0000733)2.69237121
35Gait imbalance (HP:0002141)2.61035153
36Visual hallucinations (HP:0002367)2.60884089
37Generalized hypotonia (HP:0001290)2.60240117
38Congenital stationary night blindness (HP:0007642)2.59695152
39Poor eye contact (HP:0000817)2.57730590
40Volvulus (HP:0002580)2.55462457
41Progressive inability to walk (HP:0002505)2.55290126
42Abnormal respiratory epithelium morphology (HP:0012253)2.50901978
43Abnormal respiratory motile cilium morphology (HP:0005938)2.50901978
44Retinal dysplasia (HP:0007973)2.49546621
45Atonic seizures (HP:0010819)2.48439208
46Acute necrotizing encephalopathy (HP:0006965)2.47660035
47Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.43564118
48Agitation (HP:0000713)2.43542472
49Amblyopia (HP:0000646)2.41834878
50Short philtrum (HP:0000322)2.40102640
51Progressive macrocephaly (HP:0004481)2.39257181
52Hypothermia (HP:0002045)2.38845613
53Hypoplasia of the fovea (HP:0007750)2.37796374
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.37796374
55Genital tract atresia (HP:0001827)2.37351390
56Abnormality of the renal cortex (HP:0011035)2.36648250
57Dislocated radial head (HP:0003083)2.36613739
58Autism (HP:0000717)2.34268360
59Chronic hepatic failure (HP:0100626)2.34254473
60Obstructive sleep apnea (HP:0002870)2.32329387
61Gastrointestinal atresia (HP:0002589)2.32313188
62Sporadic (HP:0003745)2.29736342
63Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.29224186
64Febrile seizures (HP:0002373)2.28628272
65Abnormal social behavior (HP:0012433)2.28508949
66Impaired social interactions (HP:0000735)2.28508949
67Oligodactyly (hands) (HP:0001180)2.26920000
68Pendular nystagmus (HP:0012043)2.24990422
69Abnormality of the radial head (HP:0003995)2.24104953
70Optic nerve hypoplasia (HP:0000609)2.23562628
71Broad-based gait (HP:0002136)2.23392643
72Nephrogenic diabetes insipidus (HP:0009806)2.18693250
73Abnormal respiratory motile cilium physiology (HP:0012261)2.18032788
74Deeply set eye (HP:0000490)2.16903091
75* Lissencephaly (HP:0001339)2.16718821
76* Limb dystonia (HP:0002451)2.16529716
77Bony spicule pigmentary retinopathy (HP:0007737)2.15982946
78Tubular atrophy (HP:0000092)2.15908156
79Truncus arteriosus (HP:0001660)2.14702687
80Cystic liver disease (HP:0006706)2.14205225
81Vaginal atresia (HP:0000148)2.13980517
82Open mouth (HP:0000194)2.12892927
83Impaired pain sensation (HP:0007328)2.12485675
84Abnormality of pain sensation (HP:0010832)2.12485675
85Mitochondrial inheritance (HP:0001427)2.11993400
86Mutism (HP:0002300)2.11407557
87Absence seizures (HP:0002121)2.11104187
88Dysdiadochokinesis (HP:0002075)2.08712353
893-Methylglutaconic aciduria (HP:0003535)2.08617236
90Poor suck (HP:0002033)2.08541254
91Thickened helices (HP:0000391)2.08152772
92Amyotrophic lateral sclerosis (HP:0007354)2.08120742
93Shoulder girdle muscle weakness (HP:0003547)2.07832677
94Abnormal mitochondria in muscle tissue (HP:0008316)2.07071314
95Polyphagia (HP:0002591)2.06660415
96Congenital primary aphakia (HP:0007707)2.05687841
97Postaxial hand polydactyly (HP:0001162)2.05253825
98Abnormality of the humeroradial joint (HP:0100744)2.04243843
99Generalized tonic-clonic seizures (HP:0002069)2.01387685
100Atrioventricular canal defect (HP:0006695)2.01332772
101Double outlet right ventricle (HP:0001719)2.00794851
102Congenital malformation of the right heart (HP:0011723)2.00794851
103Renal Fanconi syndrome (HP:0001994)1.99888786
104Abnormality of the dental root (HP:0006486)1.98907224
105Taurodontia (HP:0000679)1.98907224
106Abnormality of permanent molar morphology (HP:0011071)1.98907224
107Aplasia/Hypoplasia of the lens (HP:0008063)1.98877312
108Abnormality of the fovea (HP:0000493)1.98833330
109Truncal ataxia (HP:0002078)1.97492447
110Dynein arm defect of respiratory motile cilia (HP:0012255)1.96466313
111Absent/shortened dynein arms (HP:0200106)1.96466313
112Atelectasis (HP:0100750)1.95496461
113Acute encephalopathy (HP:0006846)1.94118722
114Dialeptic seizures (HP:0011146)1.93648086
115* Specific learning disability (HP:0001328)1.93600088
116Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92598925
117Rimmed vacuoles (HP:0003805)1.92371767
118Medial flaring of the eyebrow (HP:0010747)1.91766809
119Depression (HP:0000716)1.90937609
120Progressive sensorineural hearing impairment (HP:0000408)1.90798383
121Abnormality of molar morphology (HP:0011070)1.90519202
122Abnormality of molar (HP:0011077)1.90519202
123Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90220579
124Abnormal ciliary motility (HP:0012262)1.90005158
125Inability to walk (HP:0002540)1.89450115
126Supranuclear gaze palsy (HP:0000605)1.88874406
127Narrow nasal bridge (HP:0000446)1.88278901
128Bronchomalacia (HP:0002780)1.87889582
129Poor coordination (HP:0002370)1.87747792
130Absent speech (HP:0001344)1.87512652
131Abnormal eating behavior (HP:0100738)1.87019258
132Sleep apnea (HP:0010535)1.86924170
133Aplasia/Hypoplasia of the tongue (HP:0010295)1.86659742
134Anencephaly (HP:0002323)1.86285973
135Protruding tongue (HP:0010808)1.85747275
136* Hypsarrhythmia (HP:0002521)1.85572277
137Abnormality of the dental pulp (HP:0006479)1.85450782
138Sclerocornea (HP:0000647)1.85297390
139Abnormality of vitamin B metabolism (HP:0004340)1.85135469
140Methylmalonic acidemia (HP:0002912)1.85115760
141Postaxial foot polydactyly (HP:0001830)1.84802710
142Male pseudohermaphroditism (HP:0000037)1.84674506
143Insomnia (HP:0100785)1.84416033
144* EEG with generalized epileptiform discharges (HP:0011198)1.84228343
145Lipid accumulation in hepatocytes (HP:0006561)1.82363667
146Ankle clonus (HP:0011448)1.82200133
147Occipital encephalocele (HP:0002085)1.81112326
148Renal cortical cysts (HP:0000803)1.81078837
149Attenuation of retinal blood vessels (HP:0007843)1.81062157
150* Epileptiform EEG discharges (HP:0011182)1.80751480
151Abolished electroretinogram (ERG) (HP:0000550)1.80564971
152* Pachygyria (HP:0001302)1.79592929
153Increased hepatocellular lipid droplets (HP:0006565)1.79562629
154Gaze-evoked nystagmus (HP:0000640)1.78915264
155Abnormality of the intervertebral disk (HP:0005108)1.78344458
156Slender long bone (HP:0003100)1.78190185
157Thyroid-stimulating hormone excess (HP:0002925)1.77729332
158Palpebral edema (HP:0100540)1.77641914
159Precocious puberty (HP:0000826)1.77620019
160Widely spaced teeth (HP:0000687)1.77315563
161Exotropia (HP:0000577)1.77244838
162Patellar aplasia (HP:0006443)1.76999405
163Self-mutilation (HP:0000742)1.75007118
164Increased corneal curvature (HP:0100692)1.74939876
165Keratoconus (HP:0000563)1.74939876
166Gastroesophageal reflux (HP:0002020)1.74429067
167Abnormal drinking behavior (HP:0030082)1.74171654
168Polydipsia (HP:0001959)1.74171654
169Rhinitis (HP:0012384)1.73832128
170Hepatoblastoma (HP:0002884)1.73539248
171Abnormality of salivation (HP:0100755)1.73028368
172Pointed chin (HP:0000307)1.72913870
173Polymicrogyria (HP:0002126)1.72523815
174Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71139381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.65999490
2FRK3.83606109
3MAP4K23.62277960
4MAP3K43.25576534
5MAP2K73.09828778
6NTRK22.85481305
7MAP3K92.65893583
8PRPF4B2.60539331
9CASK2.45851679
10EPHB22.40887309
11EPHA42.35012537
12MKNK22.22942597
13WNK32.12289718
14NTRK32.07937339
15PINK11.99064368
16UHMK11.96102363
17SIK21.93359168
18MINK11.92740866
19PRKD31.90680894
20MAPK131.89855190
21DYRK21.78969984
22ICK1.69951938
23KSR11.66035951
24GRK11.50429405
25MAP2K41.43322602
26CDK51.34620033
27CSNK1G11.33954824
28PAK61.32753863
29EPHA31.32418715
30CCNB11.31051569
31DAPK21.29520427
32ADRBK21.29310080
33SGK4941.28748804
34SGK2231.28748804
35PNCK1.28678180
36TNIK1.27892508
37TAOK21.27539644
38SGK21.26832258
39STK38L1.22068116
40LATS21.20750980
41PHKG21.20504642
42PHKG11.20504642
43ERBB31.18279676
44MKNK11.17851210
45MAPK151.15225465
46TYRO31.14822154
47TAOK11.13083182
48INSRR1.08966226
49TRIM281.07594022
50LIMK11.06437192
51ERBB41.03780390
52ZAK0.97612160
53PRKD20.95809395
54OBSCN0.93862612
55DYRK1A0.93764184
56PAK30.91764927
57PKN10.91048316
58WNK40.90423864
59TAF10.89610148
60TRIB30.89062364
61OXSR10.87001116
62BRSK20.85975453
63SGK30.85780755
64MAP2K60.85380405
65PRKCG0.83991269
66MAP3K20.83585670
67CSNK1G20.82796273
68YES10.74891951
69CAMKK10.74759743
70PRKCZ0.73785192
71CAMKK20.69225194
72KSR20.68980396
73FER0.67681245
74CAMK2B0.66864143
75MAP3K120.66058781
76ROCK10.65875484
77PLK20.65764397
78PRKCH0.65469031
79DAPK10.64657998
80CAMK2A0.64325656
81FES0.64125788
82CDC42BPA0.63644045
83CDK140.63282402
84PRKCE0.61567379
85CDK180.61233788
86NME10.60911126
87VRK10.60334234
88WEE10.59726283
89BMPR1B0.58909641
90RPS6KA20.58128707
91CDK150.57638984
92BCR0.57552122
93MAP3K60.57432141
94CSNK1A10.57138259
95BRSK10.55682940
96CAMK2D0.54270412
97STK110.53901398
98CDK30.53503976
99DYRK30.53111070
100SGK10.53071885
101PRKACA0.52554103
102IRAK10.52447671
103TAOK30.50804191
104CDK11A0.50184013
105NTRK10.48344120
106NUAK10.47991635
107ROCK20.47954590
108MARK20.46928431
109PLK30.44972862
110STK390.43941564
111PRKG10.43859504
112CSNK1G30.43849432
113PDGFRA0.43347072
114TLK10.43345191
115IRAK20.42845403
116ACVR1B0.41952244
117CAMK40.41914003
118PRKCI0.40344698
119PRKAA10.40322120
120PRKACB0.40243513
121FYN0.39650437
122CSNK1D0.39454780
123CSNK1E0.39121946
124RPS6KA30.38642120
125MAPK80.38600885
126ADRBK10.37250681
127FGFR20.36966879
128SRPK10.36600401
129MAPK90.36374919
130NEK60.36246740
131DYRK1B0.36055262
132CSNK1A1L0.35829769
133CAMK10.35593289
134CDK190.35201791
135HIPK20.33912423
136MAPK100.33368696
137PTK60.32930184
138ERBB20.32223729
139GSK3B0.30728417
140LMTK20.29493414
141MST40.29299954
142CAMK2G0.28217463

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82318857
2GABAergic synapse_Homo sapiens_hsa047273.31487307
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.01426063
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78854019
5Morphine addiction_Homo sapiens_hsa050322.66648354
6Synaptic vesicle cycle_Homo sapiens_hsa047212.61659739
7Circadian entrainment_Homo sapiens_hsa047132.37795170
8Glutamatergic synapse_Homo sapiens_hsa047242.36068596
9Protein export_Homo sapiens_hsa030602.26665968
10Axon guidance_Homo sapiens_hsa043602.11758480
11Dopaminergic synapse_Homo sapiens_hsa047282.06451114
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06228744
13Insulin secretion_Homo sapiens_hsa049111.99714520
14Serotonergic synapse_Homo sapiens_hsa047261.94170614
15Olfactory transduction_Homo sapiens_hsa047401.86875618
16Cholinergic synapse_Homo sapiens_hsa047251.79689970
17Long-term potentiation_Homo sapiens_hsa047201.78665623
18Taste transduction_Homo sapiens_hsa047421.78600884
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78155174
20Amphetamine addiction_Homo sapiens_hsa050311.75752833
21Cocaine addiction_Homo sapiens_hsa050301.72169702
22Long-term depression_Homo sapiens_hsa047301.67318892
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66836274
24Gap junction_Homo sapiens_hsa045401.60635102
25Type I diabetes mellitus_Homo sapiens_hsa049401.60460005
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59195191
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58706003
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57425273
29Gastric acid secretion_Homo sapiens_hsa049711.47161308
30Oxytocin signaling pathway_Homo sapiens_hsa049211.41632085
31Renin secretion_Homo sapiens_hsa049241.40508615
32Linoleic acid metabolism_Homo sapiens_hsa005911.38631733
33Steroid biosynthesis_Homo sapiens_hsa001001.38124474
34Salivary secretion_Homo sapiens_hsa049701.37973912
35Butanoate metabolism_Homo sapiens_hsa006501.35910783
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32824499
37Folate biosynthesis_Homo sapiens_hsa007901.29179921
38Basal transcription factors_Homo sapiens_hsa030221.26805869
39Melanogenesis_Homo sapiens_hsa049161.26137908
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26008393
41GnRH signaling pathway_Homo sapiens_hsa049121.24321070
42ErbB signaling pathway_Homo sapiens_hsa040121.23526306
43Selenocompound metabolism_Homo sapiens_hsa004501.22831320
44Estrogen signaling pathway_Homo sapiens_hsa049151.22557758
45beta-Alanine metabolism_Homo sapiens_hsa004101.22511797
46Ether lipid metabolism_Homo sapiens_hsa005651.19655437
47Tryptophan metabolism_Homo sapiens_hsa003801.18453087
48Sulfur metabolism_Homo sapiens_hsa009201.17404120
49Type II diabetes mellitus_Homo sapiens_hsa049301.17248515
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16442598
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15224827
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14714588
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12507420
54Nitrogen metabolism_Homo sapiens_hsa009101.10747401
55Propanoate metabolism_Homo sapiens_hsa006401.10267293
56Calcium signaling pathway_Homo sapiens_hsa040201.05021629
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04220785
58cAMP signaling pathway_Homo sapiens_hsa040241.04029066
59Wnt signaling pathway_Homo sapiens_hsa043101.02964325
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00532735
61Endometrial cancer_Homo sapiens_hsa052130.98397938
62Alcoholism_Homo sapiens_hsa050340.96834562
63Cardiac muscle contraction_Homo sapiens_hsa042600.95785942
64Glioma_Homo sapiens_hsa052140.94159630
65Dorso-ventral axis formation_Homo sapiens_hsa043200.92726853
66Hedgehog signaling pathway_Homo sapiens_hsa043400.91542536
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89529706
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89417288
69Prion diseases_Homo sapiens_hsa050200.86122495
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85542266
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84991538
72Collecting duct acid secretion_Homo sapiens_hsa049660.84396939
73Phototransduction_Homo sapiens_hsa047440.83007186
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82534328
75Colorectal cancer_Homo sapiens_hsa052100.81459921
76Choline metabolism in cancer_Homo sapiens_hsa052310.80727557
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79301125
78RNA polymerase_Homo sapiens_hsa030200.78542752
79Peroxisome_Homo sapiens_hsa041460.76711940
80Renal cell carcinoma_Homo sapiens_hsa052110.76691768
81Ras signaling pathway_Homo sapiens_hsa040140.76592221
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.76145941
83Oocyte meiosis_Homo sapiens_hsa041140.75526737
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75495391
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73669865
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73183393
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71712632
88Basal cell carcinoma_Homo sapiens_hsa052170.71549951
89MAPK signaling pathway_Homo sapiens_hsa040100.69639258
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.68258204
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67867104
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.67625145
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.65165711
94Vibrio cholerae infection_Homo sapiens_hsa051100.64947111
95ABC transporters_Homo sapiens_hsa020100.64450449
96Alzheimers disease_Homo sapiens_hsa050100.63327548
97Histidine metabolism_Homo sapiens_hsa003400.63196163
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.63119917
99Rap1 signaling pathway_Homo sapiens_hsa040150.62949857
100Ovarian steroidogenesis_Homo sapiens_hsa049130.62862639
101Oxidative phosphorylation_Homo sapiens_hsa001900.61923959
102Melanoma_Homo sapiens_hsa052180.61113519
103Caffeine metabolism_Homo sapiens_hsa002320.60404356
104Hippo signaling pathway_Homo sapiens_hsa043900.59465422
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.59026066
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58929947
107Fanconi anemia pathway_Homo sapiens_hsa034600.58534282
108Circadian rhythm_Homo sapiens_hsa047100.58330287
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58030268
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56315403
111Insulin signaling pathway_Homo sapiens_hsa049100.55907499
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55551539
113Retinol metabolism_Homo sapiens_hsa008300.55337926
114Thyroid hormone synthesis_Homo sapiens_hsa049180.55051144
115Regulation of autophagy_Homo sapiens_hsa041400.54408324
116Metabolic pathways_Homo sapiens_hsa011000.53960027
117Glucagon signaling pathway_Homo sapiens_hsa049220.53836111
118Parkinsons disease_Homo sapiens_hsa050120.53535672
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52815132
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52568627
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.52049908
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51395058
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50501588
124Dilated cardiomyopathy_Homo sapiens_hsa054140.50331721
125RNA degradation_Homo sapiens_hsa030180.50156216
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48555547
127Notch signaling pathway_Homo sapiens_hsa043300.47839664
128Prolactin signaling pathway_Homo sapiens_hsa049170.45637954
129Fat digestion and absorption_Homo sapiens_hsa049750.44994548
130Huntingtons disease_Homo sapiens_hsa050160.44719989
131Chemical carcinogenesis_Homo sapiens_hsa052040.44619200
132Pancreatic secretion_Homo sapiens_hsa049720.43790061
133Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43682877
134VEGF signaling pathway_Homo sapiens_hsa043700.41231527
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40475801
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39337380
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39297374
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38747246
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38722189
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37992696
141mTOR signaling pathway_Homo sapiens_hsa041500.37699774
142Fatty acid elongation_Homo sapiens_hsa000620.36924131
143TGF-beta signaling pathway_Homo sapiens_hsa043500.35970471
144Fatty acid metabolism_Homo sapiens_hsa012120.34219436

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