ART3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.73673567
2cardiac myofibril assembly (GO:0055003)6.35265893
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.35030093
4carnitine shuttle (GO:0006853)6.20945519
5actin-myosin filament sliding (GO:0033275)6.17448033
6muscle filament sliding (GO:0030049)6.17448033
7tricarboxylic acid cycle (GO:0006099)5.98753421
8myofibril assembly (GO:0030239)5.97265891
9fatty acid transmembrane transport (GO:1902001)5.82987662
10regulation of sequestering of triglyceride (GO:0010889)5.77467908
11regulation of skeletal muscle contraction (GO:0014819)5.66562132
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.64142571
13negative regulation of potassium ion transmembrane transport (GO:1901380)5.60424958
14response to muscle activity (GO:0014850)5.49482374
15response to inactivity (GO:0014854)5.49400413
16carnitine transmembrane transport (GO:1902603)5.43804351
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.43771573
18regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.27583531
19actin-mediated cell contraction (GO:0070252)5.12974466
20regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.02576926
21amino-acid betaine transport (GO:0015838)5.01031643
22carnitine transport (GO:0015879)5.01031643
23cardiac muscle contraction (GO:0060048)4.94677071
24plasma membrane repair (GO:0001778)4.84244712
25regulation of relaxation of muscle (GO:1901077)4.81684388
26skeletal muscle fiber development (GO:0048741)4.70615960
27cardiac muscle cell development (GO:0055013)4.58282130
28sarcoplasmic reticulum calcium ion transport (GO:0070296)4.54398805
29regulation of actin filament-based movement (GO:1903115)4.52830927
30regulation of acyl-CoA biosynthetic process (GO:0050812)4.51658408
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.51597924
32myotube cell development (GO:0014904)4.51292896
33regulation of cell communication by electrical coupling (GO:0010649)4.33873076
34actomyosin structure organization (GO:0031032)4.33551711
35cardiac cell development (GO:0055006)4.32444952
36regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.31802136
37muscle fiber development (GO:0048747)4.31073038
38heart trabecula formation (GO:0060347)4.21942269
39striated muscle contraction (GO:0006941)4.19513120
40creatine metabolic process (GO:0006600)4.15759424
41cardiac muscle tissue morphogenesis (GO:0055008)4.13749662
42cardiac muscle hypertrophy (GO:0003300)4.12411550
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.06587801
44glucan catabolic process (GO:0009251)4.02419388
45regulation of cofactor metabolic process (GO:0051193)4.01679605
46regulation of coenzyme metabolic process (GO:0051196)4.01679605
47cilium or flagellum-dependent cell motility (GO:0001539)3.99336553
48fatty acid beta-oxidation (GO:0006635)3.98592476
49lipid particle organization (GO:0034389)3.97216359
50striated muscle hypertrophy (GO:0014897)3.96993894
51bundle of His cell to Purkinje myocyte communication (GO:0086069)3.96512502
52regulation of fatty acid oxidation (GO:0046320)3.89046723
53regulation of sarcomere organization (GO:0060297)3.88789252
54actin filament-based movement (GO:0030048)3.86160859
55ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.85670136
56muscle tissue morphogenesis (GO:0060415)3.85395937
57ventricular cardiac muscle cell action potential (GO:0086005)3.84298508
58regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.83543577
59glycogen biosynthetic process (GO:0005978)3.82962191
60glucan biosynthetic process (GO:0009250)3.82962191
61brown fat cell differentiation (GO:0050873)3.80497454
62cellular polysaccharide catabolic process (GO:0044247)3.77898383
63neuronal action potential propagation (GO:0019227)3.76729095
64regulation of striated muscle contraction (GO:0006942)3.74306961
65regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.69338083
66quaternary ammonium group transport (GO:0015697)3.67368002
67skeletal muscle tissue development (GO:0007519)3.65003225
68heart process (GO:0003015)3.64294887
69heart contraction (GO:0060047)3.64294887
70low-density lipoprotein particle clearance (GO:0034383)3.64258916
71positive regulation of fatty acid oxidation (GO:0046321)3.60606262
72adult heart development (GO:0007512)3.58832130
73biotin metabolic process (GO:0006768)3.54708278
74regulation of the force of heart contraction (GO:0002026)3.54653833
75regulation of calcium ion transmembrane transporter activity (GO:1901019)3.52700697
76regulation of calcium ion transmembrane transport (GO:1903169)3.52700697
772-oxoglutarate metabolic process (GO:0006103)3.52665045
78muscle hypertrophy (GO:0014896)3.51764655
79negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.48681044
80negative regulation of calcium ion transmembrane transport (GO:1903170)3.48681044
81polysaccharide catabolic process (GO:0000272)3.46363692
82valine metabolic process (GO:0006573)3.44236645
83response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.42214878
84NADH metabolic process (GO:0006734)3.42111961
85ubiquinone biosynthetic process (GO:0006744)3.41830974
86fusion of sperm to egg plasma membrane (GO:0007342)3.41803473
87striated muscle atrophy (GO:0014891)3.41032407
88aspartate family amino acid catabolic process (GO:0009068)3.40836639
89skeletal muscle contraction (GO:0003009)3.36920781
90positive regulation of cation channel activity (GO:2001259)3.36515288
91skeletal muscle adaptation (GO:0043501)3.34710996
92muscle cell cellular homeostasis (GO:0046716)3.32340532
93fatty acid catabolic process (GO:0009062)3.27953409
94muscle contraction (GO:0006936)3.27761084
95regulation of ATP catabolic process (GO:1903289)3.27670495
96regulation of ATPase activity (GO:0043462)3.27670495
97regulation of sulfur metabolic process (GO:0042762)3.27601332
98regulation of membrane repolarization (GO:0060306)3.26535557
99skeletal muscle tissue regeneration (GO:0043403)3.24777862
100intracellular lipid transport (GO:0032365)3.23296914
101fatty acid oxidation (GO:0019395)3.22285283
102positive regulation of fatty acid beta-oxidation (GO:0032000)3.21147023
103otic vesicle formation (GO:0030916)3.20347190
104negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.19090145
105lipid oxidation (GO:0034440)3.17547725
106triglyceride catabolic process (GO:0019433)3.17506629
107succinate metabolic process (GO:0006105)3.11999281
108muscle structure development (GO:0061061)3.11826194
109cell communication involved in cardiac conduction (GO:0086065)3.10990465
110muscle atrophy (GO:0014889)3.10234969
111relaxation of muscle (GO:0090075)3.09836807
112muscle organ development (GO:0007517)3.09749865
113muscle system process (GO:0003012)3.07531379
114response to activity (GO:0014823)3.05728344
115negative regulation of potassium ion transport (GO:0043267)3.05657763
116glycogen metabolic process (GO:0005977)3.05537047
117ubiquinone metabolic process (GO:0006743)3.04603507
118cardiac muscle hypertrophy in response to stress (GO:0014898)3.02904441
119muscle hypertrophy in response to stress (GO:0003299)3.02904441
120cardiac muscle adaptation (GO:0014887)3.02904441
121muscle adaptation (GO:0043500)3.02656695
122response to caffeine (GO:0031000)3.02644922
123regulation of muscle contraction (GO:0006937)3.02445535
124cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02299615
125neuromuscular synaptic transmission (GO:0007274)3.02149761
126regulation of muscle system process (GO:0090257)3.01720780
127regulation of cardiac muscle contraction (GO:0055117)3.00462915
128striated muscle adaptation (GO:0014888)3.00211082
129positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99776575
130regulation of cardiac muscle cell contraction (GO:0086004)2.99565321
131positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.99054352
132glycogen catabolic process (GO:0005980)2.98290472
133mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.96640992
134branched-chain amino acid catabolic process (GO:0009083)2.95409822
135response to epinephrine (GO:0071871)2.93323415
136relaxation of cardiac muscle (GO:0055119)2.93062749
137cellular response to epinephrine stimulus (GO:0071872)2.87693889
138cardiac muscle cell action potential (GO:0086001)2.84053287
139respiratory electron transport chain (GO:0022904)2.83797457
140branched-chain amino acid metabolic process (GO:0009081)2.82815192
141striated muscle cell development (GO:0055002)2.81082866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.15309744
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.34835681
3EP300_21415370_ChIP-Seq_HL-1_Mouse3.53773983
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.17540584
5TBX20_22328084_ChIP-Seq_HEART_Mouse3.03375435
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.03375435
7IGF1R_20145208_ChIP-Seq_DFB_Human2.87920648
8GBX2_23144817_ChIP-Seq_PC3_Human2.65768305
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.63825905
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.42022307
11CLOCK_20551151_ChIP-Seq_293T_Human2.33433822
12EZH2_22144423_ChIP-Seq_EOC_Human2.31073686
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.25419682
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22873057
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.22605765
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.12677244
17ZNF263_19887448_ChIP-Seq_K562_Human2.08884321
18ESR1_20079471_ChIP-ChIP_T-47D_Human2.04097107
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.03527944
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02141423
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94246202
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.92922724
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90647306
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89169397
25* ER_23166858_ChIP-Seq_MCF-7_Human1.79042447
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74541745
27MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.71789506
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71727336
29PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.67077166
30FUS_26573619_Chip-Seq_HEK293_Human1.63586298
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62668042
32* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56053443
33TAF15_26573619_Chip-Seq_HEK293_Human1.55706262
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.53374156
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.53104126
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52647876
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.52248016
38AR_21572438_ChIP-Seq_LNCaP_Human1.50243453
39PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.49490894
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48962239
41GATA1_22025678_ChIP-Seq_K562_Human1.48310085
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46870323
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44244617
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44067777
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42430317
46SMAD4_21799915_ChIP-Seq_A2780_Human1.42325017
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41890495
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.41441839
49* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37657414
50NANOG_19829295_ChIP-Seq_ESCs_Human1.36074518
51SOX2_19829295_ChIP-Seq_ESCs_Human1.36074518
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35666471
53CJUN_26792858_Chip-Seq_BT549_Human1.35279333
54P300_19829295_ChIP-Seq_ESCs_Human1.35237583
55CRX_20693478_ChIP-Seq_RETINA_Mouse1.34302952
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34294056
57* TCF4_23295773_ChIP-Seq_U87_Human1.33231007
58NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31891477
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.30788463
60* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29835726
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28495064
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28025320
63SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.27391248
64BCAT_22108803_ChIP-Seq_LS180_Human1.24374067
65STAT3_23295773_ChIP-Seq_U87_Human1.24295238
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23852999
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.23296447
68AR_25329375_ChIP-Seq_VCAP_Human1.21177454
69HTT_18923047_ChIP-ChIP_STHdh_Human1.19829212
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19441847
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19367549
72OCT4_20526341_ChIP-Seq_ESCs_Human1.18134096
73* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17984799
74* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17912016
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17699337
76OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17683984
77PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17067562
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17037163
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15655025
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14324968
81* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12120439
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11305366
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.11101115
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10843352
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.10673379
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10180560
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.10122674
88* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10049744
89TP53_22573176_ChIP-Seq_HFKS_Human1.09201290
90PHF8_20622853_ChIP-Seq_HELA_Human1.06060688
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04840925
92* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04160999
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03555666
94CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03058809
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.02849361
96RXR_22158963_ChIP-Seq_LIVER_Mouse1.02583437
97ZNF274_21170338_ChIP-Seq_K562_Hela1.02389364
98P53_22387025_ChIP-Seq_ESCs_Mouse1.00140590
99* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99689175
100BP1_19119308_ChIP-ChIP_Hs578T_Human0.98862304
101GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98246971
102* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.98209908
103* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97714710
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.97393320
105SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96886957
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96591137
107NFYB_21822215_ChIP-Seq_K562_Human0.96501652
108* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96241968
109ETV1_20927104_ChIP-Seq_GIST48_Human0.95265614
110HOXB7_26014856_ChIP-Seq_BT474_Human0.94963082
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94510056
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.94021890
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.93917610
114CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93846923
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93752145
116RNF2_27304074_Chip-Seq_NSC_Mouse0.93637474
117TBL1_22424771_ChIP-Seq_293T_Human0.93580993
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93499452
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92810335
120EZH2_27304074_Chip-Seq_ESCs_Mouse0.92078543
121PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.91659073
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91545437
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91394704
124CBP_20019798_ChIP-Seq_JUKART_Human0.91394704
125* MYC_19829295_ChIP-Seq_ESCs_Human0.91018003
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90938376
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90938376
128GATA6_21074721_ChIP-Seq_CACO-2_Human0.90650791
129TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90477974
130TP63_22573176_ChIP-Seq_HFKS_Human0.85594689
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84287930
132RUNX1_27514584_Chip-Seq_MCF-7_Human0.84186061
133VDR_24787735_ChIP-Seq_THP-1_Human0.84022169
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83150259
135SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82826166
136DROSHA_22980978_ChIP-Seq_HELA_Human0.82811671
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.82536785
138CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81827071
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81162352
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80408125
141ELK4_26923725_Chip-Seq_MESODERM_Mouse0.78178524
142IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78033708
143GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77634758
144TCF4_18268006_ChIP-ChIP_LS174T_Human0.77419409
145FOXA2_19822575_ChIP-Seq_HepG2_Human0.77228805
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76299575
147NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76299575
148ISL1_27105846_Chip-Seq_CPCs_Mouse0.76046123
149CSB_26484114_Chip-Seq_FIBROBLAST_Human0.75882362
150SPI1_20517297_ChIP-Seq_HL60_Human0.74403396
151P63_26484246_Chip-Seq_KERATINOCYTES_Human0.73745219
152WDR5_24793694_ChIP-Seq_LNCAP_Human0.73680707
153PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73628458
154JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73182944
155SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73093246
156FOXH1_21741376_ChIP-Seq_ESCs_Human0.72789209
157HIF1A_21447827_ChIP-Seq_MCF-7_Human0.72197441
158CTCF_27219007_Chip-Seq_Bcells_Human0.71589316
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.70925034
160GATA1_19941826_ChIP-Seq_K562_Human0.70121760
161PCGF2_27294783_Chip-Seq_NPCs_Mouse0.70101067
162MTF2_20144788_ChIP-Seq_MESCs_Mouse0.69808594
163SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.69612639
164RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69596438
165VDR_22108803_ChIP-Seq_LS180_Human0.68979969
166KLF4_19829295_ChIP-Seq_ESCs_Human0.68439805
167PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68188113
168UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.67772665
169MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.67756323
170TP63_17297297_ChIP-ChIP_HaCaT_Human0.67519880
171WT1_25993318_ChIP-Seq_PODOCYTE_Human0.67463900
172CBP_21632823_ChIP-Seq_H3396_Human0.67050564
173ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66703531
174AHR_22903824_ChIP-Seq_MCF-7_Human0.66679871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.83643713
2MP0003646_muscle_fatigue5.39080517
3MP0000751_myopathy4.83511958
4MP0004084_abnormal_cardiac_muscle4.39757406
5MP0004215_abnormal_myocardial_fiber3.89219459
6MP0004130_abnormal_muscle_cell3.81765142
7MP0005670_abnormal_white_adipose3.75825429
8MP0004036_abnormal_muscle_relaxation3.74251519
9MP0000749_muscle_degeneration3.74135017
10MP0005330_cardiomyopathy3.21593256
11MP0005666_abnormal_adipose_tissue2.97132081
12MP0004087_abnormal_muscle_fiber2.84013315
13MP0000750_abnormal_muscle_regeneration2.72443435
14MP0008775_abnormal_heart_ventricle2.70281719
15MP0005620_abnormal_muscle_contractility2.69872167
16MP0002972_abnormal_cardiac_muscle2.64000807
17MP0004145_abnormal_muscle_electrophysio2.57097607
18MP0004185_abnormal_adipocyte_glucose2.44152360
19MP0002106_abnormal_muscle_physiology2.37041746
20MP0004484_altered_response_of2.25233404
21MP0006138_congestive_heart_failure2.22774489
22MP0005385_cardiovascular_system_phenoty2.22193330
23MP0001544_abnormal_cardiovascular_syste2.22193330
24MP0010630_abnormal_cardiac_muscle2.13967621
25MP0005375_adipose_tissue_phenotype2.07975703
26MP0003828_pulmonary_edema2.05948893
27MP0002269_muscular_atrophy2.03522603
28MP0005451_abnormal_body_composition2.02765298
29MP0003137_abnormal_impulse_conducting2.00458849
30MP0000759_abnormal_skeletal_muscle1.98367355
31MP0000747_muscle_weakness1.94897808
32MP0005369_muscle_phenotype1.93445757
33MP0008438_abnormal_cutaneous_collagen1.82643794
34MP0005410_abnormal_fertilization1.75454402
35MP0003950_abnormal_plasma_membrane1.73335585
36MP0004272_abnormal_basement_membrane1.60520163
37MP0000013_abnormal_adipose_tissue1.60180615
38MP0002332_abnormal_exercise_endurance1.57856506
39MP0004085_abnormal_heartbeat1.56962786
40MP0003221_abnormal_cardiomyocyte_apopto1.55152014
41MP0006036_abnormal_mitochondrial_physio1.52425716
42MP0004233_abnormal_muscle_weight1.51514681
43MP0005275_abnormal_skin_tensile1.46566562
44MP0004510_myositis1.44632215
45MP0002971_abnormal_brown_adipose1.44205215
46MP0000343_altered_response_to1.39872477
47MP0004270_analgesia1.38705189
48MP0000003_abnormal_adipose_tissue1.26311012
49MP0002127_abnormal_cardiovascular_syste1.24321284
50MP0001879_abnormal_lymphatic_vessel1.20081252
51MP0003279_aneurysm1.18759002
52MP0002108_abnormal_muscle_morphology1.16179060
53MP0005623_abnormal_meninges_morphology1.13839846
54MP0009115_abnormal_fat_cell1.03850148
55MP0003045_fibrosis1.02429507
56MP0001661_extended_life_span0.96294557
57MP0005165_increased_susceptibility_to0.95373576
58MP0000230_abnormal_systemic_arterial0.94712795
59MP0010368_abnormal_lymphatic_system0.93945858
60MP0000266_abnormal_heart_morphology0.91562909
61MP0005334_abnormal_fat_pad0.90987306
62MP0004147_increased_porphyrin_level0.90410150
63MP0000372_irregular_coat_pigmentation0.89990041
64MP0002638_abnormal_pupillary_reflex0.88412989
65MP0004142_abnormal_muscle_tone0.87070541
66MP0001984_abnormal_olfaction0.81234428
67MP0003566_abnormal_cell_adhesion0.80578061
68MP0003705_abnormal_hypodermis_morpholog0.75769238
69MP0006276_abnormal_autonomic_nervous0.74805678
70MP0002876_abnormal_thyroid_physiology0.72532839
71MP0002128_abnormal_blood_circulation0.71541603
72MP0005535_abnormal_body_temperature0.71374203
73MP0002272_abnormal_nervous_system0.70156595
74MP0008877_abnormal_DNA_methylation0.70046780
75MP0002118_abnormal_lipid_homeostasis0.68081420
76MP0005551_abnormal_eye_electrophysiolog0.67792453
77MP0009745_abnormal_behavioral_response0.67715831
78MP0000733_abnormal_muscle_development0.67549674
79MP0002970_abnormal_white_adipose0.66171639
80MP0001529_abnormal_vocalization0.65573830
81MP0001501_abnormal_sleep_pattern0.65289130
82MP0005266_abnormal_metabolism0.64770666
83MP0002078_abnormal_glucose_homeostasis0.61251458
84MP0005645_abnormal_hypothalamus_physiol0.60045996
85MP0005386_behavior/neurological_phenoty0.59681610
86MP0004924_abnormal_behavior0.59681610
87MP0009384_cardiac_valve_regurgitation0.59633942
88MP0003567_abnormal_fetal_cardiomyocyte0.59457862
89MP0005253_abnormal_eye_physiology0.59251254
90MP0008961_abnormal_basal_metabolism0.58683498
91MP0010329_abnormal_lipoprotein_level0.58305453
92MP0003879_abnormal_hair_cell0.57685623
93MP0002234_abnormal_pharynx_morphology0.56592648
94MP0009046_muscle_twitch0.56490122
95MP0001727_abnormal_embryo_implantation0.56385289
96MP0002822_catalepsy0.55824307
97MP0008569_lethality_at_weaning0.55260411
98MP0005319_abnormal_enzyme/_coenzyme0.54995349
99MP0001486_abnormal_startle_reflex0.54943274
100MP0005332_abnormal_amino_acid0.54609125
101MP0002909_abnormal_adrenal_gland0.53817125
102MP0005595_abnormal_vascular_smooth0.52541982
103MP0006035_abnormal_mitochondrial_morpho0.52286590
104MP0002067_abnormal_sensory_capabilities0.52050251
105MP0005167_abnormal_blood-brain_barrier0.51316318
106MP0000767_abnormal_smooth_muscle0.50395808
107MP0005646_abnormal_pituitary_gland0.49935679
108MP0001485_abnormal_pinna_reflex0.49659190
109MP0003959_abnormal_lean_body0.48511200
110MP0002734_abnormal_mechanical_nocicepti0.47931321
111MP0002064_seizures0.47587810
112MP0001299_abnormal_eye_distance/0.46381830
113MP0005423_abnormal_somatic_nervous0.45428989
114MP0006072_abnormal_retinal_apoptosis0.44848865
115MP0005452_abnormal_adipose_tissue0.44719338
116MP0003011_delayed_dark_adaptation0.43307282
117MP0003136_yellow_coat_color0.42671059
118MP0009780_abnormal_chondrocyte_physiolo0.42628730
119MP0003191_abnormal_cellular_cholesterol0.42413561
120MP0001958_emphysema0.41761256
121MP0003948_abnormal_gas_homeostasis0.41684318
122MP0003724_increased_susceptibility_to0.41584331
123MP0004043_abnormal_pH_regulation0.41573937
124MP0000249_abnormal_blood_vessel0.41399398
125MP0008872_abnormal_physiological_respon0.40161390
126MP0001614_abnormal_blood_vessel0.40152662
127MP0002066_abnormal_motor_capabilities/c0.39347778
128MP0005187_abnormal_penis_morphology0.38693165
129MP0003698_abnormal_male_reproductive0.38535847
130MP0005503_abnormal_tendon_morphology0.38450583
131MP0003635_abnormal_synaptic_transmissio0.38330765
132MP0002160_abnormal_reproductive_system0.37171645
133MP0005448_abnormal_energy_balance0.37038487
134MP0002925_abnormal_cardiovascular_devel0.36574446
135MP0002295_abnormal_pulmonary_circulatio0.36156609
136MP0004134_abnormal_chest_morphology0.35773928
137MP0002166_altered_tumor_susceptibility0.33824377
138MP0005376_homeostasis/metabolism_phenot0.33005817
139MP0002133_abnormal_respiratory_system0.32950757
140MP0005388_respiratory_system_phenotype0.32950757
141MP0001853_heart_inflammation0.31557185

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.33894733
2Exercise-induced myalgia (HP:0003738)6.19226542
3Calf muscle hypertrophy (HP:0008981)5.88415568
4Exercise-induced muscle cramps (HP:0003710)5.84536908
5Ventricular tachycardia (HP:0004756)5.79096709
6Muscle fiber splitting (HP:0003555)5.67456131
7Muscle hypertrophy of the lower extremities (HP:0008968)5.58273231
8Myoglobinuria (HP:0002913)5.38035398
9Hyporeflexia of lower limbs (HP:0002600)5.22963917
10Lipoatrophy (HP:0100578)4.80524784
11Difficulty running (HP:0009046)4.74933307
12Atrial fibrillation (HP:0005110)4.72954931
13Myopathic facies (HP:0002058)4.67818251
14Abnormality of the calf musculature (HP:0001430)4.65897103
15Increased connective tissue (HP:0009025)4.42921660
16Primary atrial arrhythmia (HP:0001692)4.36961695
17Rhabdomyolysis (HP:0003201)4.18200716
18Supraventricular tachycardia (HP:0004755)4.18111986
19Right ventricular cardiomyopathy (HP:0011663)4.16569222
20Supraventricular arrhythmia (HP:0005115)4.14223612
21Bundle branch block (HP:0011710)3.92385540
22Ulnar deviation of the wrist (HP:0003049)3.72669146
23Dilated cardiomyopathy (HP:0001644)3.71666047
24Abnormality of the left ventricular outflow tract (HP:0011103)3.67435005
25Subaortic stenosis (HP:0001682)3.67435005
26EMG: myopathic abnormalities (HP:0003458)3.66055455
27Asymmetric septal hypertrophy (HP:0001670)3.65638316
28Palpitations (HP:0001962)3.54012594
29Type 1 muscle fiber predominance (HP:0003803)3.46141730
30Syncope (HP:0001279)3.42455321
31Centrally nucleated skeletal muscle fibers (HP:0003687)3.41654264
32Myotonia (HP:0002486)3.41267306
33Absent phalangeal crease (HP:0006109)3.36190138
34Muscle fiber inclusion bodies (HP:0100299)3.31113604
35Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.25860769
36Frequent falls (HP:0002359)3.24577226
37Calcaneovalgus deformity (HP:0001848)3.23937451
38Prolonged QT interval (HP:0001657)3.20159083
39Heart block (HP:0012722)3.15203508
40Increased variability in muscle fiber diameter (HP:0003557)3.10548085
41Muscle stiffness (HP:0003552)3.08841496
42Difficulty climbing stairs (HP:0003551)3.06129131
43Abnormal atrioventricular conduction (HP:0005150)2.99905304
44Ventricular arrhythmia (HP:0004308)2.94600444
45Deformed tarsal bones (HP:0008119)2.89213694
46Atrioventricular block (HP:0001678)2.88501177
47Facial diplegia (HP:0001349)2.86942331
48Abnormality of skeletal muscle fiber size (HP:0012084)2.86504029
49Hypoplastic ischia (HP:0003175)2.85861072
50Malignant hyperthermia (HP:0002047)2.85797075
51Abnormal finger flexion creases (HP:0006143)2.84782381
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.79276963
53Nemaline bodies (HP:0003798)2.73202770
54Neck muscle weakness (HP:0000467)2.60362884
55Insulin-resistant diabetes mellitus (HP:0000831)2.59845175
56Oligomenorrhea (HP:0000876)2.59157385
57Hypoglycemic coma (HP:0001325)2.58630288
58Abnormality of the ischium (HP:0003174)2.52492668
59Hyperkalemia (HP:0002153)2.52432330
60Distal lower limb muscle weakness (HP:0009053)2.48512036
61Ketoacidosis (HP:0001993)2.47913578
62Ventricular fibrillation (HP:0001663)2.41121466
63Areflexia of lower limbs (HP:0002522)2.40238621
64Abnormality of fatty-acid metabolism (HP:0004359)2.39483231
65Increased muscle lipid content (HP:0009058)2.36312179
66Left ventricular hypertrophy (HP:0001712)2.35508799
67Broad metatarsal (HP:0001783)2.31723496
68Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31451800
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.30718322
70Absent/shortened dynein arms (HP:0200106)2.30718322
71Hepatic necrosis (HP:0002605)2.29473488
72Impaired proprioception (HP:0010831)2.28633283
73Abnormal mitochondria in muscle tissue (HP:0008316)2.28587470
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28171652
75Dicarboxylic aciduria (HP:0003215)2.28171652
76Muscular dystrophy (HP:0003560)2.27763081
77Weak cry (HP:0001612)2.26002725
78Abnormal EKG (HP:0003115)2.25037613
79Distal arthrogryposis (HP:0005684)2.23662267
80Acute necrotizing encephalopathy (HP:0006965)2.22724104
81Fatigable weakness (HP:0003473)2.22612671
82Abnormality of the neuromuscular junction (HP:0003398)2.22612671
83Fetal akinesia sequence (HP:0001989)2.22367042
84Acanthosis nigricans (HP:0000956)2.21163792
85Foot dorsiflexor weakness (HP:0009027)2.19113252
86Testicular atrophy (HP:0000029)2.19012989
87Abnormality of the foot musculature (HP:0001436)2.11755679
88Rimmed vacuoles (HP:0003805)2.10364232
89Bulbar palsy (HP:0001283)2.09625994
90Hyperglycinuria (HP:0003108)2.08833203
91Gowers sign (HP:0003391)2.07006829
92Spinal rigidity (HP:0003306)2.06180090
93Scapular winging (HP:0003691)2.05192691
94Palmoplantar keratoderma (HP:0000982)2.03948737
95Bone cyst (HP:0012062)2.03473770
96Round ear (HP:0100830)1.99775364
97Acute encephalopathy (HP:0006846)1.99242513
98Toxemia of pregnancy (HP:0100603)1.99173034
99Proximal amyotrophy (HP:0007126)1.98109330
100Abnormality of the nasal mucosa (HP:0000433)1.97630185
101Ketosis (HP:0001946)1.96581074
102Generalized muscle weakness (HP:0003324)1.95922113
103Conjunctival hamartoma (HP:0100780)1.95442054
104Hypoalphalipoproteinemia (HP:0003233)1.94437021
105Progressive macrocephaly (HP:0004481)1.94420225
106Hip contracture (HP:0003273)1.93392681
107EMG: neuropathic changes (HP:0003445)1.91618654
108Limb-girdle muscle atrophy (HP:0003797)1.89207380
109Abnormal respiratory motile cilium physiology (HP:0012261)1.88899412
110Abnormality of alanine metabolism (HP:0010916)1.88499747
111Hyperalaninemia (HP:0003348)1.88499747
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88499747
113Abnormality of the shoulder girdle musculature (HP:0001435)1.88478198
114Mildly elevated creatine phosphokinase (HP:0008180)1.87422343
115Progressive muscle weakness (HP:0003323)1.87357565
116Cerebral edema (HP:0002181)1.85497397
117Increased intramyocellular lipid droplets (HP:0012240)1.84888428
118Large for gestational age (HP:0001520)1.83678051
119Exercise intolerance (HP:0003546)1.83622869
120Ulnar claw (HP:0001178)1.82852992
121Type 2 muscle fiber atrophy (HP:0003554)1.82749879
122Waddling gait (HP:0002515)1.79735580
123Respiratory insufficiency due to muscle weakness (HP:0002747)1.71609351
124Nonprogressive disorder (HP:0003680)1.70849662
125Ragged-red muscle fibers (HP:0003200)1.68089089
126Shoulder girdle muscle weakness (HP:0003547)1.65290734
127Slender build (HP:0001533)1.61924725
128Hepatocellular necrosis (HP:0001404)1.61361582
129Abnormality of the calcaneus (HP:0008364)1.61245606
130Mitochondrial inheritance (HP:0001427)1.60582582
131Distal lower limb amyotrophy (HP:0008944)1.60508013

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.43039589
2PDK45.43039589
3TTN5.20774691
4OBSCN3.87921939
5PHKG13.70289857
6PHKG23.70289857
7PDK23.66536533
8MYLK3.54301030
9LMTK23.33096045
10TRIB32.67607455
11DMPK2.29670028
12BCKDK2.27579938
13TIE12.09634381
14FRK1.96081153
15PIK3CA1.88413733
16PINK11.77252228
17PKN21.53225436
18CAMK1D1.46940045
19MARK11.45124382
20MUSK1.36966106
21STK241.30711159
22PTK2B1.26825920
23WNK41.26038464
24CAMK1G1.22445036
25PRKD31.22069616
26PRKAA21.12952781
27RIPK11.10250574
28BMPR1B1.03518786
29STK391.02983239
30NEK11.02593016
31CCNB11.01747322
32SIK10.98401082
33MAP2K40.95151794
34PDGFRA0.94984055
35PRKD10.92087926
36MAPK130.91777958
37ILK0.88787145
38PRKAA10.87902141
39MAP4K20.87258988
40MAP2K30.86955873
41GRK70.86865583
42STK38L0.84462814
43TGFBR20.84309787
44PAK30.83163009
45ERBB30.82622336
46MAP2K60.81746618
47MAPK120.80723030
48WNK30.80617568
49INSRR0.80601502
50GRK10.79678103
51DAPK20.77482315
52OXSR10.77244625
53NEK90.76693293
54ROCK10.76618265
55ICK0.75472431
56LIMK10.74910633
57PIK3CG0.73809738
58ADRBK20.73621568
59EPHB20.73490280
60TNIK0.71101604
61MAP3K30.70207194
62NLK0.67978962
63WNK10.66453605
64EPHB10.65382168
65CAMK2D0.64858066
66ZAK0.63718090
67MAPKAPK30.63662031
68MAP3K70.60967630
69MAP3K40.59388229
70STK380.58508767
71KDR0.57551920
72TRPM70.56665431
73CAMK2B0.51556973
74LATS10.50280020
75ACVR1B0.49696126
76FGFR30.49511084
77TAOK30.49086809
78SGK20.48843773
79PDK10.47350081
80JAK10.47030476
81MAPK70.46811311
82PDPK10.46704273
83NME10.46526299
84CDC42BPA0.46235773
85PKN10.45663284
86PAK20.45136728
87FER0.44265763
88DAPK30.43407536
89FGFR40.43338444
90PRKACG0.42507426
91CAMK10.42482580
92PNCK0.41686471
93MAP3K50.40351981
94ERN10.37814046
95PRKG20.37728404
96AKT20.37354960
97PLK20.37026651
98IRAK10.36064589
99PRKACB0.35160322
100STK110.34307160
101SGK10.33486442
102MAPK40.33359016
103MST1R0.32698528
104RET0.32693241
105MAPK110.32449417
106PDGFRB0.32149004
107CAMK40.31386251
108RPS6KA30.30999755
109MOS0.30930697
110PRKACA0.30769350
111STK40.29352439
112ADRBK10.29175764
113PRKCH0.28193484
114PTK60.26636533
115CAMK2G0.26020643
116PRKG10.25890758
117TBK10.25809675
118SGK30.25806174
119MAPKAPK50.25046514
120STK30.24952208
121MTOR0.24873194
122MAP2K10.24857600
123ROCK20.24252224
124EPHA40.24217176
125CAMK2A0.24148220
126DYRK1B0.23816824
127CDK190.23197367
128RPS6KL10.22932416
129RPS6KC10.22932416
130PRKCE0.22872316
131TESK10.22384013
132SGK4940.22338701
133SGK2230.22338701
134DDR20.21984338
135FLT30.21953713
136MARK30.21792403
137GSK3A0.20711899
138CASK0.20080981
139PAK60.20033850
140IRAK20.19948839
141RPS6KA60.18783338
142TNK20.18446119
143RPS6KA10.18388560
144RPS6KB10.18060370
145UHMK10.17842906
146JAK20.16840735
147NTRK30.16333256
148EPHA30.16301912
149PRKCG0.14653429
150PRKCA0.13901060
151EEF2K0.13640199
152MAPK100.13409225

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.39632455
2Propanoate metabolism_Homo sapiens_hsa006404.30672597
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.41357039
4Cardiac muscle contraction_Homo sapiens_hsa042603.20207380
5Fatty acid degradation_Homo sapiens_hsa000713.06231024
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.88848972
7Dilated cardiomyopathy_Homo sapiens_hsa054142.87534616
8Fatty acid metabolism_Homo sapiens_hsa012122.72445459
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63305936
10PPAR signaling pathway_Homo sapiens_hsa033202.53551373
11Pyruvate metabolism_Homo sapiens_hsa006202.52116448
12Carbon metabolism_Homo sapiens_hsa012002.38050623
13Fatty acid biosynthesis_Homo sapiens_hsa000612.17012469
14Parkinsons disease_Homo sapiens_hsa050122.12495228
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.09891746
16Oxidative phosphorylation_Homo sapiens_hsa001902.04142965
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.88349036
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.81788900
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76266413
20Nitrogen metabolism_Homo sapiens_hsa009101.69671230
21Alzheimers disease_Homo sapiens_hsa050101.68078693
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65739039
23Huntingtons disease_Homo sapiens_hsa050161.60386579
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.58869701
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50141135
26Glucagon signaling pathway_Homo sapiens_hsa049221.47202860
27Viral myocarditis_Homo sapiens_hsa054161.37851599
28Phototransduction_Homo sapiens_hsa047441.30947776
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30931298
30Insulin resistance_Homo sapiens_hsa049311.29060056
31AMPK signaling pathway_Homo sapiens_hsa041521.25067924
32Glycerolipid metabolism_Homo sapiens_hsa005611.23641674
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22992753
34Fatty acid elongation_Homo sapiens_hsa000621.21416245
35ECM-receptor interaction_Homo sapiens_hsa045121.13797808
36Insulin signaling pathway_Homo sapiens_hsa049101.10833331
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09969866
38Butanoate metabolism_Homo sapiens_hsa006501.06197311
39Focal adhesion_Homo sapiens_hsa045101.04001469
40Circadian entrainment_Homo sapiens_hsa047131.02122113
41beta-Alanine metabolism_Homo sapiens_hsa004101.01918664
42Regulation of autophagy_Homo sapiens_hsa041400.95280035
43Starch and sucrose metabolism_Homo sapiens_hsa005000.93661549
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92016292
45Olfactory transduction_Homo sapiens_hsa047400.86985482
46Renin secretion_Homo sapiens_hsa049240.86259690
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84960799
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.79071068
49Calcium signaling pathway_Homo sapiens_hsa040200.78135166
50Biosynthesis of amino acids_Homo sapiens_hsa012300.77191429
51Dorso-ventral axis formation_Homo sapiens_hsa043200.76919850
52Peroxisome_Homo sapiens_hsa041460.74221546
53HIF-1 signaling pathway_Homo sapiens_hsa040660.73239620
54Fat digestion and absorption_Homo sapiens_hsa049750.69829198
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67806721
56Tryptophan metabolism_Homo sapiens_hsa003800.66523989
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.65110448
58Phenylalanine metabolism_Homo sapiens_hsa003600.65098215
59Oxytocin signaling pathway_Homo sapiens_hsa049210.62995586
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62402507
61Type II diabetes mellitus_Homo sapiens_hsa049300.60407339
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58738707
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58331380
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57177195
65Histidine metabolism_Homo sapiens_hsa003400.55965820
66Amphetamine addiction_Homo sapiens_hsa050310.55511158
67Tight junction_Homo sapiens_hsa045300.54765757
68Fructose and mannose metabolism_Homo sapiens_hsa000510.54584133
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54469710
70GABAergic synapse_Homo sapiens_hsa047270.54189257
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52974571
72Lysine degradation_Homo sapiens_hsa003100.50351524
73RNA degradation_Homo sapiens_hsa030180.50124050
74Pentose phosphate pathway_Homo sapiens_hsa000300.50018617
75Arginine biosynthesis_Homo sapiens_hsa002200.49485838
76Purine metabolism_Homo sapiens_hsa002300.49296767
77Morphine addiction_Homo sapiens_hsa050320.49129392
78Protein digestion and absorption_Homo sapiens_hsa049740.48827094
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48644772
80Caffeine metabolism_Homo sapiens_hsa002320.48516092
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47664255
82Ether lipid metabolism_Homo sapiens_hsa005650.47509838
83cAMP signaling pathway_Homo sapiens_hsa040240.47407993
84Amoebiasis_Homo sapiens_hsa051460.46970810
85Nicotine addiction_Homo sapiens_hsa050330.46618310
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44780810
87ABC transporters_Homo sapiens_hsa020100.44360013
88Taste transduction_Homo sapiens_hsa047420.43921760
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.43474999
90Long-term depression_Homo sapiens_hsa047300.40133091
91Cholinergic synapse_Homo sapiens_hsa047250.37807833
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37492889
93Gastric acid secretion_Homo sapiens_hsa049710.36670458
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36636052
95Adherens junction_Homo sapiens_hsa045200.36623018
96Arginine and proline metabolism_Homo sapiens_hsa003300.36578691
97Tyrosine metabolism_Homo sapiens_hsa003500.36137718
98Long-term potentiation_Homo sapiens_hsa047200.35884496
99Oocyte meiosis_Homo sapiens_hsa041140.35824129
100GnRH signaling pathway_Homo sapiens_hsa049120.35669258
101Toxoplasmosis_Homo sapiens_hsa051450.34980913
102Serotonergic synapse_Homo sapiens_hsa047260.34396714
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34115622
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.33695751
105Vitamin B6 metabolism_Homo sapiens_hsa007500.33214473
106Glutamatergic synapse_Homo sapiens_hsa047240.33203952
107Dopaminergic synapse_Homo sapiens_hsa047280.33117801
108Pancreatic secretion_Homo sapiens_hsa049720.33074140
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31710462
110Galactose metabolism_Homo sapiens_hsa000520.31663185
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30571911
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.28237391
113Circadian rhythm_Homo sapiens_hsa047100.27609124
114Proteoglycans in cancer_Homo sapiens_hsa052050.26060525
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.25946311
116Basal transcription factors_Homo sapiens_hsa030220.25759290
117Selenocompound metabolism_Homo sapiens_hsa004500.25101328
118Small cell lung cancer_Homo sapiens_hsa052220.24111077
119VEGF signaling pathway_Homo sapiens_hsa043700.24043404
120Linoleic acid metabolism_Homo sapiens_hsa005910.22366597
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21836269
122Platelet activation_Homo sapiens_hsa046110.21205403
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19454110
124Metabolic pathways_Homo sapiens_hsa011000.19349288
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15951871
126Ovarian steroidogenesis_Homo sapiens_hsa049130.13393687
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10512597
128Renal cell carcinoma_Homo sapiens_hsa052110.09010697
129Bile secretion_Homo sapiens_hsa049760.08481099
130Estrogen signaling pathway_Homo sapiens_hsa049150.06493255
131Salivary secretion_Homo sapiens_hsa049700.05873194
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.05639565
133mTOR signaling pathway_Homo sapiens_hsa041500.05519604
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.05465071
135Insulin secretion_Homo sapiens_hsa049110.05280047

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