ARSK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of transcription from RNA polymerase I promoter (GO:0006356)4.61522889
2snRNA transcription (GO:0009301)4.33247515
3mitotic metaphase plate congression (GO:0007080)4.29520896
4water-soluble vitamin biosynthetic process (GO:0042364)4.12971918
5low-density lipoprotein particle remodeling (GO:0034374)4.10321523
6DNA deamination (GO:0045006)4.09518767
7behavioral response to nicotine (GO:0035095)3.94686682
8establishment of protein localization to mitochondrial membrane (GO:0090151)3.86172320
9definitive hemopoiesis (GO:0060216)3.81419256
10negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.80577243
11lens morphogenesis in camera-type eye (GO:0002089)3.66229429
12purine nucleobase biosynthetic process (GO:0009113)3.50658055
13response to pheromone (GO:0019236)3.47857256
14respiratory chain complex IV assembly (GO:0008535)3.47426330
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45664003
16regulation of interferon-beta biosynthetic process (GO:0045357)3.41168773
17maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.39872117
18meiotic chromosome segregation (GO:0045132)3.38274098
19proteasome assembly (GO:0043248)3.32700623
20metaphase plate congression (GO:0051310)3.32280569
21regulation of retinoic acid receptor signaling pathway (GO:0048385)3.31671180
22negative regulation of keratinocyte proliferation (GO:0010839)3.28590621
23regulation of exit from mitosis (GO:0007096)3.28286544
24protein neddylation (GO:0045116)3.28154649
25regulation of RNA export from nucleus (GO:0046831)3.27191912
26monoubiquitinated protein deubiquitination (GO:0035520)3.24913009
27protein complex biogenesis (GO:0070271)3.24609181
28mitochondrial respiratory chain complex assembly (GO:0033108)3.21464566
29protein-cofactor linkage (GO:0018065)3.19161190
30cullin deneddylation (GO:0010388)3.16859361
31DNA double-strand break processing (GO:0000729)3.15581090
32ATP synthesis coupled proton transport (GO:0015986)3.12478283
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12478283
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08287418
35peptidyl-histidine modification (GO:0018202)3.06749964
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.04200897
37NADH dehydrogenase complex assembly (GO:0010257)3.04200897
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04200897
39somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03815385
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.03815385
41rRNA modification (GO:0000154)3.02894273
42protein deneddylation (GO:0000338)3.02668315
43indole-containing compound catabolic process (GO:0042436)3.02056179
44indolalkylamine catabolic process (GO:0046218)3.02056179
45tryptophan catabolic process (GO:0006569)3.02056179
46cytochrome complex assembly (GO:0017004)3.00311629
47detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00123503
48cellular response to thyroid hormone stimulus (GO:0097067)2.98408631
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.98054915
50ribosome assembly (GO:0042255)2.96798653
51synapsis (GO:0007129)2.95995462
52nonmotile primary cilium assembly (GO:0035058)2.94532441
53chromatin remodeling at centromere (GO:0031055)2.94322170
54platelet dense granule organization (GO:0060155)2.93390255
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93097881
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91591527
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90673849
58regulation of meiosis I (GO:0060631)2.90246549
59mitotic G2 DNA damage checkpoint (GO:0007095)2.90172004
60kynurenine metabolic process (GO:0070189)2.87052752
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86721021
62L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86584078
63mannosylation (GO:0097502)2.86028812
64indolalkylamine metabolic process (GO:0006586)2.84901764
65preassembly of GPI anchor in ER membrane (GO:0016254)2.84623687
66rRNA methylation (GO:0031167)2.79859798
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.77080959
68positive regulation by organism of defense response of other organism involved in symbiotic interact2.77080959
69modulation by symbiont of host immune response (GO:0052553)2.77080959
70positive regulation by symbiont of host defense response (GO:0052509)2.77080959
71modulation by symbiont of host defense response (GO:0052031)2.77080959
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.77080959
73maturation of 5.8S rRNA (GO:0000460)2.76580710
74recombinational repair (GO:0000725)2.76172920
75cilium morphogenesis (GO:0060271)2.75398318
76RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.74407736
77double-strand break repair via homologous recombination (GO:0000724)2.73576681
78RNA capping (GO:0036260)2.72324248
797-methylguanosine RNA capping (GO:0009452)2.72324248
80negative regulation of transcription regulatory region DNA binding (GO:2000678)2.71882767
81positive regulation of granulocyte differentiation (GO:0030854)2.71750512
82fucose catabolic process (GO:0019317)2.70557905
83L-fucose metabolic process (GO:0042354)2.70557905
84L-fucose catabolic process (GO:0042355)2.70557905
85regulation of germinal center formation (GO:0002634)2.70009017
86regulation of nuclear cell cycle DNA replication (GO:0033262)2.69134940
87regulation of establishment of cell polarity (GO:2000114)2.68639639
88DNA replication checkpoint (GO:0000076)2.68626969
89regulation of cilium movement (GO:0003352)2.67894651
90negative regulation of alcohol biosynthetic process (GO:1902931)2.67591501
91centrosome duplication (GO:0051298)2.66681897
92positive regulation of protein import into nucleus, translocation (GO:0033160)2.65647496
93piRNA metabolic process (GO:0034587)2.65627759
94negative regulation of DNA-dependent DNA replication (GO:2000104)2.64330038
95CENP-A containing nucleosome assembly (GO:0034080)2.63463820
96response to nitrosative stress (GO:0051409)2.63335828
97protein K6-linked ubiquitination (GO:0085020)2.62766800
98negative regulation of telomere maintenance (GO:0032205)2.62089215
99tryptophan metabolic process (GO:0006568)2.61914028
100cellular response to arsenic-containing substance (GO:0071243)2.61479379
101axon ensheathment in central nervous system (GO:0032291)2.61297125
102central nervous system myelination (GO:0022010)2.61297125
103regulation of mesoderm development (GO:2000380)2.60924328
104histone exchange (GO:0043486)2.60294338
105epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58772884
106regulation of mitotic spindle checkpoint (GO:1903504)2.58209237
107regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58209237
108response to interferon-beta (GO:0035456)2.57975197
109nucleobase biosynthetic process (GO:0046112)2.57863870
110mitotic sister chromatid cohesion (GO:0007064)2.56850924
111resolution of meiotic recombination intermediates (GO:0000712)2.56787687
112retinal cone cell development (GO:0046549)2.55669504
113regulation of nucleobase-containing compound transport (GO:0032239)2.55041816
114intracellular protein transmembrane import (GO:0044743)2.54489252
115replication fork processing (GO:0031297)2.54465206
116amino acid salvage (GO:0043102)2.54083824
117L-methionine salvage (GO:0071267)2.54083824
118L-methionine biosynthetic process (GO:0071265)2.54083824
119phagocytosis, engulfment (GO:0006911)2.53556522
120DNA synthesis involved in DNA repair (GO:0000731)2.52684082
121somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.52599871
122isotype switching (GO:0045190)2.52599871
123somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.52599871
124tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52520805
125RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52520805
126signal peptide processing (GO:0006465)2.50560951
127epithelial cilium movement (GO:0003351)2.49960307
128nucleotide transmembrane transport (GO:1901679)2.49364478
129termination of RNA polymerase III transcription (GO:0006386)2.48777054
130transcription elongation from RNA polymerase III promoter (GO:0006385)2.48777054
131sister chromatid cohesion (GO:0007062)2.48532636
132G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48071112
133sphingosine metabolic process (GO:0006670)2.47577097
134transcription elongation from RNA polymerase II promoter (GO:0006368)2.46642177
135N-terminal protein amino acid modification (GO:0031365)2.46272989
136cilium organization (GO:0044782)2.46148511
137kidney morphogenesis (GO:0060993)2.46098211
138C4-dicarboxylate transport (GO:0015740)2.45096745
139otic vesicle formation (GO:0030916)2.44829528
140somite development (GO:0061053)2.44315121
141female gamete generation (GO:0007292)2.43756534
142establishment of chromosome localization (GO:0051303)2.43709144
143cellular response to exogenous dsRNA (GO:0071360)2.43651148
144microglial cell activation (GO:0001774)2.42982011
145regulation of T cell migration (GO:2000404)2.42488545
146regulation of platelet aggregation (GO:0090330)2.42123607
147electron transport chain (GO:0022900)2.42095116
148mitotic G2/M transition checkpoint (GO:0044818)2.41672214
149regulation of spindle organization (GO:0090224)2.41218476
150positive regulation of interferon-beta production (GO:0032728)2.40911375
151pyrimidine-containing compound transmembrane transport (GO:0072531)2.40814704
152regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.40385172
153male meiosis I (GO:0007141)2.40362110
154C-terminal protein lipidation (GO:0006501)2.40333702
155DNA catabolic process, exonucleolytic (GO:0000738)2.39885195
156C-terminal protein amino acid modification (GO:0018410)2.39646014
157sulfation (GO:0051923)2.39292715
158meiosis I (GO:0007127)2.37245999
159N-terminal protein amino acid acetylation (GO:0006474)2.37042612
160regulation of keratinocyte proliferation (GO:0010837)2.36800156
1617-methylguanosine mRNA capping (GO:0006370)2.36577426
162ubiquinone metabolic process (GO:0006743)2.36406590
163intraciliary transport (GO:0042073)2.36264771
164respiratory electron transport chain (GO:0022904)2.35769148
165cilium assembly (GO:0042384)2.35312271
166postreplication repair (GO:0006301)2.34782822
167response to thyroid hormone (GO:0097066)2.33837870
168chaperone-mediated protein transport (GO:0072321)2.33385272
169urate metabolic process (GO:0046415)2.33223962
170nephron epithelium morphogenesis (GO:0072088)2.32728751
171nephron tubule morphogenesis (GO:0072078)2.32728751
172protein K11-linked deubiquitination (GO:0035871)2.31447058
173negative regulation of viral entry into host cell (GO:0046597)2.31124957
174protein localization to chromosome, centromeric region (GO:0071459)2.30595202
175adenosine metabolic process (GO:0046085)2.30439044
176left/right axis specification (GO:0070986)2.30222772
177positive regulation of T cell migration (GO:2000406)2.28679354
178positive regulation of cellular amine metabolic process (GO:0033240)2.27986099
179negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.27984457
180negative regulation of DNA-templated transcription, elongation (GO:0032785)2.27984457
181poly(A)+ mRNA export from nucleus (GO:0016973)2.27133031
182cysteine metabolic process (GO:0006534)2.26928920
183mast cell activation (GO:0045576)2.26185425
184termination of RNA polymerase I transcription (GO:0006363)2.25489261
185regulation of energy homeostasis (GO:2000505)2.24639516
186neutrophil activation involved in immune response (GO:0002283)2.24180426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.81471002
2E2F7_22180533_ChIP-Seq_HELA_Human3.84721199
3ZNF274_21170338_ChIP-Seq_K562_Hela3.46040947
4VDR_22108803_ChIP-Seq_LS180_Human3.00920938
5KAP1_22055183_ChIP-Seq_ESCs_Mouse2.98015493
6AR_21909140_ChIP-Seq_LNCAP_Human2.71231787
7SCL_19346495_ChIP-Seq_HPC-7_Human2.70683580
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69163731
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.67617204
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.61816525
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57638665
12GBX2_23144817_ChIP-Seq_PC3_Human2.56592002
13* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54302686
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45852561
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.43942168
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.33533172
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.22928060
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14994219
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.12221430
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.11385517
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05844880
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05614200
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05022165
24P300_19829295_ChIP-Seq_ESCs_Human2.03283498
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02091396
26TAF15_26573619_Chip-Seq_HEK293_Human2.01670481
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01338683
28HOXB4_20404135_ChIP-ChIP_EML_Mouse2.00478343
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.98594444
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.98458586
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95713910
32* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92009949
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.88333215
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85579904
35* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75666646
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.69888493
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68715477
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67716396
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65278601
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.64538673
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.61518688
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60515894
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59274484
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57865235
45* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56144633
46* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54252543
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52092406
48LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52028399
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51772156
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.51634103
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51021113
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50866612
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50808690
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50701033
55SPI1_23547873_ChIP-Seq_NB4_Human1.48371746
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46226697
57VDR_23849224_ChIP-Seq_CD4+_Human1.46201793
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45367440
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41719059
60ER_23166858_ChIP-Seq_MCF-7_Human1.41260501
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41023099
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40526665
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40488458
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40247027
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40013684
66* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39146123
67BCAT_22108803_ChIP-Seq_LS180_Human1.38176708
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37059263
69SMAD4_21799915_ChIP-Seq_A2780_Human1.35456085
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35072023
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34666472
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34159722
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33324400
74ELK1_19687146_ChIP-ChIP_HELA_Human1.33279521
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33134834
76CBP_20019798_ChIP-Seq_JUKART_Human1.33134834
77AR_25329375_ChIP-Seq_VCAP_Human1.32232444
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32003594
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31451186
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.30812420
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29771498
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28660592
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28189862
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27478710
85TP53_22573176_ChIP-Seq_HFKS_Human1.27368062
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27150537
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.26958647
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.25159105
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24472021
90BP1_19119308_ChIP-ChIP_Hs578T_Human1.23942072
91* SOX2_19829295_ChIP-Seq_ESCs_Human1.22868171
92* NANOG_19829295_ChIP-Seq_ESCs_Human1.22868171
93STAT3_23295773_ChIP-Seq_U87_Human1.22702324
94NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21030231
95* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20417165
96EZH2_22144423_ChIP-Seq_EOC_Human1.19456127
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19441590
98TCF4_22108803_ChIP-Seq_LS180_Human1.17985807
99RNF2_27304074_Chip-Seq_NSC_Mouse1.16511681
100* TCF4_23295773_ChIP-Seq_U87_Human1.15169502
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.14983163
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12694836
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12444720
104ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12292805
105FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10992518
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10928508
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.10709393
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.08791807
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08791807
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08309813
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.07213386
112IRF1_19129219_ChIP-ChIP_H3396_Human1.06823457
113RUNX2_22187159_ChIP-Seq_PCA_Human1.05864672
114MYC_18940864_ChIP-ChIP_HL60_Human1.05674574
115RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05100659
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03755362
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03574318
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03564111
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03460673
120MYB_26560356_Chip-Seq_TH2_Human1.02512474
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02206844
122SMAD4_21741376_ChIP-Seq_EPCs_Human1.02122742
123TAL1_26923725_Chip-Seq_HPCs_Mouse1.01989715
124STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01495428
125STAT1_20625510_ChIP-Seq_HELA_Human1.00490388
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00139938
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00003388
128P53_22387025_ChIP-Seq_ESCs_Mouse0.99844333
129MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99734099
130CDX2_22108803_ChIP-Seq_LS180_Human0.98814698
131FLI1_21867929_ChIP-Seq_TH2_Mouse0.98505140
132JUN_21703547_ChIP-Seq_K562_Human0.98273574
133NANOG_18555785_Chip-Seq_ESCs_Mouse0.98137844
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.97293405
135* FOXP3_21729870_ChIP-Seq_TREG_Human0.96813116
136AR_20517297_ChIP-Seq_VCAP_Human0.96652131
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95808749
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95808749
139SALL1_21062744_ChIP-ChIP_HESCs_Human0.95651703
140FUS_26573619_Chip-Seq_HEK293_Human0.95521570
141PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.95228991
142RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94198995
143SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93385350
144IGF1R_20145208_ChIP-Seq_DFB_Human0.93211030
145EZH2_27294783_Chip-Seq_NPCs_Mouse0.92560659
146SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92427007
147EWS_26573619_Chip-Seq_HEK293_Human0.91442366
148ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91151126
149FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90978468
150* ERG_20517297_ChIP-Seq_VCAP_Human0.89880897
151AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89809543
152GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89520386
153* ETS1_20019798_ChIP-Seq_JURKAT_Human0.89190939
154MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88651354
155SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86370451
156STAT3_18555785_Chip-Seq_ESCs_Mouse0.85936463
157TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85149265
158MYB_26560356_Chip-Seq_TH1_Human0.84936674
159* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.84746789
160EOMES_21245162_ChIP-Seq_HESCs_Human0.83908066
161E2F1_21310950_ChIP-Seq_MCF-7_Human0.83860499
162SALL4_22934838_ChIP-ChIP_CD34+_Human0.82422954
163EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82241839
164GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82169804
165EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81589397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.46927656
2MP0006292_abnormal_olfactory_placode3.18096376
3MP0002396_abnormal_hematopoietic_system2.93284876
4MP0008007_abnormal_cellular_replicative2.66611236
5MP0006072_abnormal_retinal_apoptosis2.60737823
6MP0005408_hypopigmentation2.43214049
7MP0008877_abnormal_DNA_methylation2.41345981
8MP0002736_abnormal_nociception_after2.36713069
9MP0004147_increased_porphyrin_level2.28534583
10MP0003941_abnormal_skin_development2.24924001
11MP0005084_abnormal_gallbladder_morpholo2.22428689
12MP0003136_yellow_coat_color2.16106058
13MP0003195_calcinosis2.15474071
14MP0001968_abnormal_touch/_nociception2.06532295
15MP0002234_abnormal_pharynx_morphology2.01360376
16MP0005551_abnormal_eye_electrophysiolog1.98051094
17MP0003724_increased_susceptibility_to1.97945867
18MP0009333_abnormal_splenocyte_physiolog1.95879720
19MP0000465_gastrointestinal_hemorrhage1.93449970
20MP0000569_abnormal_digit_pigmentation1.92171225
21MP0001986_abnormal_taste_sensitivity1.92097508
22MP0008057_abnormal_DNA_replication1.88105508
23MP0002277_abnormal_respiratory_mucosa1.81294647
24MP0004133_heterotaxia1.79387451
25MP0005451_abnormal_body_composition1.78557944
26MP0003656_abnormal_erythrocyte_physiolo1.76641844
27MP0002132_abnormal_respiratory_system1.74889289
28MP0005253_abnormal_eye_physiology1.71925213
29MP0003693_abnormal_embryo_hatching1.69308853
30MP0000372_irregular_coat_pigmentation1.68113208
31MP0003283_abnormal_digestive_organ1.63157145
32MP0005464_abnormal_platelet_physiology1.61730426
33MP0001984_abnormal_olfaction1.60306714
34MP0001188_hyperpigmentation1.60100652
35MP0001835_abnormal_antigen_presentation1.59728035
36MP0000427_abnormal_hair_cycle1.58875438
37MP0001529_abnormal_vocalization1.56075893
38MP0003890_abnormal_embryonic-extraembry1.55437530
39MP0003436_decreased_susceptibility_to1.54963219
40MP0003077_abnormal_cell_cycle1.54529472
41MP0001293_anophthalmia1.54109305
42MP0002837_dystrophic_cardiac_calcinosis1.53525831
43MP0002102_abnormal_ear_morphology1.52869375
44MP0005671_abnormal_response_to1.52673096
45MP0009384_cardiac_valve_regurgitation1.52209275
46MP0000631_abnormal_neuroendocrine_gland1.48608058
47MP0002419_abnormal_innate_immunity1.44957398
48MP0000049_abnormal_middle_ear1.43653623
49MP0009840_abnormal_foam_cell1.41483291
50MP0006054_spinal_hemorrhage1.40843293
51MP0005000_abnormal_immune_tolerance1.39118422
52MP0003111_abnormal_nucleus_morphology1.37880455
53MP0002060_abnormal_skin_morphology1.37659125
54MP0010386_abnormal_urinary_bladder1.36532221
55MP0003186_abnormal_redox_activity1.34792204
56MP0009046_muscle_twitch1.34641880
57MP0003119_abnormal_digestive_system1.33495566
58MP0005187_abnormal_penis_morphology1.33422470
59MP0008789_abnormal_olfactory_epithelium1.32962773
60MP0004381_abnormal_hair_follicle1.32801343
61MP0002751_abnormal_autonomic_nervous1.32419622
62MP0008872_abnormal_physiological_respon1.31696594
63MP0000647_abnormal_sebaceous_gland1.29145001
64MP0009785_altered_susceptibility_to1.28646668
65MP0005646_abnormal_pituitary_gland1.26096989
66MP0005645_abnormal_hypothalamus_physiol1.26008860
67MP0004142_abnormal_muscle_tone1.25668134
68MP0004215_abnormal_myocardial_fiber1.25545711
69MP0003279_aneurysm1.24580425
70MP0001853_heart_inflammation1.24540475
71MP0001545_abnormal_hematopoietic_system1.24513247
72MP0005397_hematopoietic_system_phenotyp1.24513247
73MP0003718_maternal_effect1.23920476
74MP0003868_abnormal_feces_composition1.23843741
75MP0010094_abnormal_chromosome_stability1.23626012
76MP0002009_preneoplasia1.23391562
77MP0000490_abnormal_crypts_of1.23264633
78MP0008875_abnormal_xenobiotic_pharmacok1.22980945
79MP0002938_white_spotting1.22375859
80MP0002160_abnormal_reproductive_system1.22076673
81MP0000343_altered_response_to1.21403457
82MP0003011_delayed_dark_adaptation1.20957913
83MP0002254_reproductive_system_inflammat1.20472730
84MP0009697_abnormal_copulation1.20209634
85MP0003690_abnormal_glial_cell1.19270533
86MP0003950_abnormal_plasma_membrane1.17612897
87MP0005075_abnormal_melanosome_morpholog1.17148044
88MP0005647_abnormal_sex_gland1.15774161
89MP0006276_abnormal_autonomic_nervous1.15554380
90MP0008058_abnormal_DNA_repair1.15177613
91MP0002233_abnormal_nose_morphology1.12220858
92MP0009745_abnormal_behavioral_response1.11752658
93MP0002452_abnormal_antigen_presenting1.11138341
94MP0002272_abnormal_nervous_system1.11110628
95MP0001119_abnormal_female_reproductive1.10775536
96MP0005025_abnormal_response_to1.10369016
97MP0005367_renal/urinary_system_phenotyp1.09151586
98MP0000516_abnormal_urinary_system1.09151586
99MP0005195_abnormal_posterior_eye1.07341709
100MP0003938_abnormal_ear_development1.07329833
101MP0004808_abnormal_hematopoietic_stem1.06915054
102MP0008775_abnormal_heart_ventricle1.06373881
103MP0004885_abnormal_endolymph1.06373517
104MP0002928_abnormal_bile_duct1.06295067
105MP0003763_abnormal_thymus_physiology1.05479186
106MP0005058_abnormal_lysosome_morphology1.05357166
107MP0003828_pulmonary_edema1.04583426
108MP0002148_abnormal_hypersensitivity_rea1.04413306
109MP0002723_abnormal_immune_serum1.04306098
110MP0002876_abnormal_thyroid_physiology1.03998657
111MP0010030_abnormal_orbit_morphology1.03621516
112MP0001800_abnormal_humoral_immune1.03602098
113MP0006082_CNS_inflammation1.02903172
114MP0009780_abnormal_chondrocyte_physiolo1.02779540
115MP0004272_abnormal_basement_membrane1.02242768
116MP0001958_emphysema1.02186869
117MP0000689_abnormal_spleen_morphology1.01961645
118MP0001324_abnormal_eye_pigmentation1.00560124
119MP0001286_abnormal_eye_development1.00434178
120MP0005391_vision/eye_phenotype1.00212475
121MP0003880_abnormal_central_pattern0.99862091
122MP0006035_abnormal_mitochondrial_morpho0.99782049
123MP0005197_abnormal_uvea_morphology0.99672785
124MP0005410_abnormal_fertilization0.98588089
125MP0003567_abnormal_fetal_cardiomyocyte0.97910483
126MP0010155_abnormal_intestine_physiology0.97467986
127MP0004264_abnormal_extraembryonic_tissu0.97413450
128MP0003786_premature_aging0.97389044
129MP0002638_abnormal_pupillary_reflex0.95460393
130MP0002420_abnormal_adaptive_immunity0.95269145
131MP0002163_abnormal_gland_morphology0.94661994
132MP0005171_absent_coat_pigmentation0.93449298
133MP0003937_abnormal_limbs/digits/tail_de0.93144570
134MP0000920_abnormal_myelination0.92955123
135MP0009250_abnormal_appendicular_skeleto0.92819403
136MP0005389_reproductive_system_phenotype0.92704680
137MP0002166_altered_tumor_susceptibility0.92291126
138MP0009764_decreased_sensitivity_to0.92157867
139MP0008932_abnormal_embryonic_tissue0.91690256
140MP0001299_abnormal_eye_distance/0.91644728
141MP0005365_abnormal_bile_salt0.91606465
142MP0002210_abnormal_sex_determination0.91002166
143MP0003806_abnormal_nucleotide_metabolis0.90872201
144MP0001819_abnormal_immune_cell0.90710863
145MP0001851_eye_inflammation0.90423878
146MP0003755_abnormal_palate_morphology0.89785418
147MP0005379_endocrine/exocrine_gland_phen0.89734831
148MP0000538_abnormal_urinary_bladder0.89408178
149MP0002282_abnormal_trachea_morphology0.88587553
150MP0002735_abnormal_chemical_nociception0.88294914
151MP0000383_abnormal_hair_follicle0.88178827
152MP0002405_respiratory_system_inflammati0.87666210
153MP0001533_abnormal_skeleton_physiology0.87593186
154MP0003191_abnormal_cellular_cholesterol0.87528613
155MP0002398_abnormal_bone_marrow0.87197185
156MP0001929_abnormal_gametogenesis0.86084537
157MP0001845_abnormal_inflammatory_respons0.85429160
158MP0000716_abnormal_immune_system0.85135373
159MP0005390_skeleton_phenotype0.84545775
160MP0005174_abnormal_tail_pigmentation0.83856928
161MP0001661_extended_life_span0.83670032
162MP0002249_abnormal_larynx_morphology0.81645286
163MP0002722_abnormal_immune_system0.81070720
164MP0005394_taste/olfaction_phenotype0.80195671
165MP0005499_abnormal_olfactory_system0.80195671
166MP0004085_abnormal_heartbeat0.79956987
167MP0002095_abnormal_skin_pigmentation0.79789918
168MP0000653_abnormal_sex_gland0.79432874
169MP0004134_abnormal_chest_morphology0.78847926
170MP0003878_abnormal_ear_physiology0.78689792
171MP0005377_hearing/vestibular/ear_phenot0.78689792
172MP0005666_abnormal_adipose_tissue0.77843402
173MP0004185_abnormal_adipocyte_glucose0.77464455
174MP0000358_abnormal_cell_content/0.77327582
175MP0010307_abnormal_tumor_latency0.76356790
176MP0001486_abnormal_startle_reflex0.76058359
177MP0008438_abnormal_cutaneous_collagen0.74781104
178MP0001485_abnormal_pinna_reflex0.74428382

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.00553479
2Molar tooth sign on MRI (HP:0002419)3.96797844
3Abnormality of midbrain morphology (HP:0002418)3.96797844
4Prostate neoplasm (HP:0100787)3.45884012
5Abnormality of secondary sexual hair (HP:0009888)3.39731270
6Abnormality of the axillary hair (HP:0100134)3.39731270
7Nephronophthisis (HP:0000090)3.37457756
8Facial hemangioma (HP:0000329)3.34315316
9Capillary hemangiomas (HP:0005306)3.28536846
10Acute necrotizing encephalopathy (HP:0006965)3.17554793
11Medial flaring of the eyebrow (HP:0010747)3.08428573
12Breast hypoplasia (HP:0003187)3.05724016
13Acute encephalopathy (HP:0006846)2.96082516
143-Methylglutaconic aciduria (HP:0003535)2.90851038
15Colon cancer (HP:0003003)2.87944235
16Congenital, generalized hypertrichosis (HP:0004540)2.87635192
17Acute myeloid leukemia (HP:0004808)2.86012801
18Thrombocytosis (HP:0001894)2.83177819
19Progressive macrocephaly (HP:0004481)2.82126022
20Abnormality of the renal medulla (HP:0100957)2.81056308
21Type II lissencephaly (HP:0007260)2.80795731
22Azoospermia (HP:0000027)2.75500547
23Abnormality of the renal cortex (HP:0011035)2.75193784
24Abnormality of the heme biosynthetic pathway (HP:0010472)2.73700212
25Abnormal mitochondria in muscle tissue (HP:0008316)2.69522943
26Increased CSF lactate (HP:0002490)2.67939909
27Mitochondrial inheritance (HP:0001427)2.67271355
28Spontaneous abortion (HP:0005268)2.62326235
29Abnormality of cochlea (HP:0000375)2.60550257
30Recurrent abscess formation (HP:0002722)2.59758278
31Adrenal hypoplasia (HP:0000835)2.58069550
32Methylmalonic acidemia (HP:0002912)2.56107696
33Congenital stationary night blindness (HP:0007642)2.55602591
34Abnormal biliary tract physiology (HP:0012439)2.54889997
35Bile duct proliferation (HP:0001408)2.54889997
36Recurrent bacterial skin infections (HP:0005406)2.53188204
37Abnormality of the prostate (HP:0008775)2.52721727
38Abnormal spermatogenesis (HP:0008669)2.50792357
39Abnormality of the columella (HP:0009929)2.45286482
40Hemiparesis (HP:0001269)2.43629254
41Abnormality of the labia minora (HP:0012880)2.40215442
42Cystic liver disease (HP:0006706)2.39338890
43Abolished electroretinogram (ERG) (HP:0000550)2.36838829
44Breech presentation (HP:0001623)2.36142879
45Abnormality of the ileum (HP:0001549)2.34224242
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.32313149
47Congenital primary aphakia (HP:0007707)2.32054936
48Flat capital femoral epiphysis (HP:0003370)2.31548238
49Sclerocornea (HP:0000647)2.31089466
50Morphological abnormality of the inner ear (HP:0011390)2.31054533
51Hepatocellular necrosis (HP:0001404)2.30257922
52Hypoplasia of the uterus (HP:0000013)2.29195388
53Abnormality of male internal genitalia (HP:0000022)2.27777800
54Gait imbalance (HP:0002141)2.26812101
55Renal cortical cysts (HP:0000803)2.25712050
56Postaxial foot polydactyly (HP:0001830)2.25452554
57Pancreatic fibrosis (HP:0100732)2.23614274
58Reduced antithrombin III activity (HP:0001976)2.23116887
59Clubbing of toes (HP:0100760)2.22997986
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.20959637
61Vacuolated lymphocytes (HP:0001922)2.20803929
62Lip pit (HP:0100267)2.20447728
63Abnormal hair whorl (HP:0010721)2.19105704
64Intestinal atresia (HP:0011100)2.17737223
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14479520
66Abnormality of alanine metabolism (HP:0010916)2.14479520
67Hyperalaninemia (HP:0003348)2.14479520
68Abnormality of the hepatic vasculature (HP:0006707)2.13729884
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12147834
70Progressive inability to walk (HP:0002505)2.12022863
71Aplasia/hypoplasia of the uterus (HP:0008684)2.11436956
72Aplasia/Hypoplasia of the tibia (HP:0005772)2.10898497
73Bilateral microphthalmos (HP:0007633)2.10773924
74Hepatic necrosis (HP:0002605)2.10539750
75Keratoconus (HP:0000563)2.10502764
76Increased corneal curvature (HP:0100692)2.10502764
77Myocardial infarction (HP:0001658)2.09931730
78Myositis (HP:0100614)2.08919825
79Hypoplastic labia majora (HP:0000059)2.08835548
80Pancreatic cysts (HP:0001737)2.08586889
81Nephrogenic diabetes insipidus (HP:0009806)2.08466710
82Patchy hypopigmentation of hair (HP:0011365)2.07715463
83Pendular nystagmus (HP:0012043)2.07362400
84Myelodysplasia (HP:0002863)2.06598129
85Chromsome breakage (HP:0040012)2.06400625
86Tubular atrophy (HP:0000092)2.06352880
87Cerebellar dysplasia (HP:0007033)2.04829382
88Genital tract atresia (HP:0001827)2.04725116
89Optic nerve hypoplasia (HP:0000609)2.04182297
90Hypergonadotropic hypogonadism (HP:0000815)2.00655483
91Anencephaly (HP:0002323)2.00147523
92Methylmalonic aciduria (HP:0012120)1.99358006
93Steatorrhea (HP:0002570)1.98806528
94Stomach cancer (HP:0012126)1.98639793
95Inability to walk (HP:0002540)1.98317488
96Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.98058998
97Abnormal delivery (HP:0001787)1.97958058
98Vaginal atresia (HP:0000148)1.97955282
99Short tibia (HP:0005736)1.97614602
100Postaxial hand polydactyly (HP:0001162)1.97164153
101Occipital encephalocele (HP:0002085)1.96265287
102Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.95873557
103Hyperglycinemia (HP:0002154)1.94762728
104Abnormal drinking behavior (HP:0030082)1.93452613
105Polydipsia (HP:0001959)1.93452613
106Glomerulonephritis (HP:0000099)1.92257882
107Breast aplasia (HP:0100783)1.92255991
108Abnormality of chromosome stability (HP:0003220)1.91815938
109Abnormality of the phalanges of the 2nd finger (HP:0009541)1.91777092
110Gingival bleeding (HP:0000225)1.91524224
111Hyperglycinuria (HP:0003108)1.89180604
112Increased serum lactate (HP:0002151)1.88596945
113Short hallux (HP:0010109)1.88540500
114White forelock (HP:0002211)1.88267380
115Cerebral edema (HP:0002181)1.88217193
116Hepatosplenomegaly (HP:0001433)1.87551654
117Abnormality of the labia majora (HP:0012881)1.87359559
118Congenital hepatic fibrosis (HP:0002612)1.87078924
119Abnormality of lateral ventricle (HP:0030047)1.86187412
120Chronic hepatic failure (HP:0100626)1.85680346
121Aplasia/Hypoplasia of the hallux (HP:0008362)1.85505413
122Abnormality of macrophages (HP:0004311)1.84799776
123Abnormal protein glycosylation (HP:0012346)1.84305210
124Abnormal glycosylation (HP:0012345)1.84305210
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84305210
126Abnormal protein N-linked glycosylation (HP:0012347)1.84305210
127Aplasia/Hypoplasia of the fovea (HP:0008060)1.84130032
128Hypoplasia of the fovea (HP:0007750)1.84130032
129Prolonged bleeding time (HP:0003010)1.83965884
130Attenuation of retinal blood vessels (HP:0007843)1.83867544
131Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83352104
132Clitoromegaly (HP:0000057)1.82775133
133Flared iliac wings (HP:0002869)1.82484424
134True hermaphroditism (HP:0010459)1.82370471
135Sensorimotor neuropathy (HP:0007141)1.81503273
136Rough bone trabeculation (HP:0100670)1.81465067
137Abnormality of incisor morphology (HP:0011063)1.81434793
138Dandy-Walker malformation (HP:0001305)1.81224710
139Optic disc pallor (HP:0000543)1.81121526
140Aplasia/Hypoplasia of the breasts (HP:0010311)1.80604236
141Male pseudohermaphroditism (HP:0000037)1.80585380
142Large for gestational age (HP:0001520)1.80427428
143Hypothermia (HP:0002045)1.79070117
144Abnormal number of erythroid precursors (HP:0012131)1.78874085
145Glioma (HP:0009733)1.78743543
146Lissencephaly (HP:0001339)1.78658387
147Stillbirth (HP:0003826)1.78643537
148Lipid accumulation in hepatocytes (HP:0006561)1.78495566
149Hyperventilation (HP:0002883)1.78359416
150Increased hepatocellular lipid droplets (HP:0006565)1.77582282
151Patellar aplasia (HP:0006443)1.77199578
152Furrowed tongue (HP:0000221)1.77036444
153Hyperlipoproteinemia (HP:0010980)1.76582079
154Severe muscular hypotonia (HP:0006829)1.76233856
155Abnormality of the septum pellucidum (HP:0007375)1.76201517
156Meckel diverticulum (HP:0002245)1.76140757
157Bifid tongue (HP:0010297)1.74832610
158Supernumerary spleens (HP:0009799)1.74803807
159Broad alveolar ridges (HP:0000187)1.74717483
160Aplasia involving bones of the upper limbs (HP:0009823)1.74264479
161Aplasia of the phalanges of the hand (HP:0009802)1.74264479
162Aplasia involving bones of the extremities (HP:0009825)1.74264479
163Epistaxis (HP:0000421)1.74125669
164Chronic otitis media (HP:0000389)1.73761588
165Sparse eyelashes (HP:0000653)1.72892597
166Progressive neurologic deterioration (HP:0002344)1.72711113
167Concave nail (HP:0001598)1.71853565
168Blepharitis (HP:0000498)1.71219195
169Small hand (HP:0200055)1.71101342
170Absent septum pellucidum (HP:0001331)1.70805417
171Short middle phalanx of the 5th finger (HP:0004220)1.70682837
172Premature skin wrinkling (HP:0100678)1.70638904
173Recurrent skin infections (HP:0001581)1.70351722
174Abnormality of serum amino acid levels (HP:0003112)1.69994605
175Abnormality of the pons (HP:0007361)1.69794773
176Disproportionate short-trunk short stature (HP:0003521)1.69623533
177Abnormality of serine family amino acid metabolism (HP:0010894)1.69543482
178Abnormality of glycine metabolism (HP:0010895)1.69543482
179Oculomotor apraxia (HP:0000657)1.69039319
180Lactic acidosis (HP:0003128)1.68557585
181Carpal bone hypoplasia (HP:0001498)1.68181866
182Aplasia/Hypoplasia of the patella (HP:0006498)1.68076170
183Bone marrow hypocellularity (HP:0005528)1.68067747
184Abnormality of the fovea (HP:0000493)1.66758289
185Abnormality of the alveolar ridges (HP:0006477)1.66467594
186Biconcave vertebral bodies (HP:0004586)1.66117128
187Progressive muscle weakness (HP:0003323)1.64589859
188Acute lymphatic leukemia (HP:0006721)1.63168459
189Type 2 muscle fiber atrophy (HP:0003554)1.62615160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK4.14274097
2MAP3K63.59000145
3NLK3.05828566
4WNK32.94589698
5PNCK2.77694752
6TRIM282.65379659
7MKNK12.54124755
8LATS12.49773588
9TEC2.49173116
10DYRK32.46924418
11BRSK22.43545029
12MKNK22.41883750
13KIT2.26009414
14TSSK62.07319154
15ACVR1B2.03450156
16IRAK31.98093106
17TAOK31.94924584
18WEE11.94312756
19MAPKAPK51.85707703
20WNK41.84058411
21GRK11.83398719
22MAP4K21.75341132
23MAP2K31.74566158
24PLK31.72162862
25LATS21.72082403
26MST41.68626116
27TNIK1.64937967
28MAP3K41.55815824
29STK31.55515827
30SRPK11.54473117
31VRK21.53145972
32EIF2AK11.51841880
33MAPK131.48729016
34CASK1.46730351
35VRK11.46525121
36PINK11.45945968
37TRPM71.44623843
38EPHA31.44010148
39CSNK1G11.42134295
40PLK21.41148013
41FRK1.39076619
42ERBB31.38948878
43BUB11.37822899
44NUAK11.35529194
45TIE11.31443471
46CSF1R1.31309835
47TAF11.28394253
48NEK11.26075919
49DYRK21.21429383
50RPS6KA41.18496841
51CDK31.15829552
52ZAP701.15526878
53OXSR11.15390689
54INSRR1.11698224
55TYK21.11457663
56CLK11.11310916
57STK38L1.10463327
58NEK21.10055911
59BCR1.07070571
60NEK61.04269280
61AURKB1.00479228
62STK240.99743071
63ERBB40.99667568
64TGFBR10.97878544
65STK160.97403506
66PIK3CG0.96518206
67IRAK40.95383525
68PRKCE0.94069940
69ADRBK10.90676792
70PBK0.87842977
71TXK0.86776626
72JAK30.86771572
73PRKCG0.86231694
74STK100.85726674
75TGFBR20.85080265
76MAP2K70.84281168
77EIF2AK20.82272379
78PAK30.80655254
79MAPKAPK30.78703556
80MARK30.77353406
81SGK20.75880229
82RPS6KA50.75082424
83PDK20.74815039
84MAPK150.73439080
85ABL20.73178678
86TLK10.72843120
87EIF2AK30.72490569
88HIPK20.71468443
89NME10.71309659
90BTK0.70716165
91LYN0.70373557
92CAMKK20.69106296
93RPS6KB20.68936234
94BMPR1B0.68527527
95PHKG10.67980996
96PHKG20.67980996
97AKT30.66028481
98IKBKE0.65810726
99DYRK1A0.65284203
100FLT30.65218681
101CDK70.64985191
102GRK70.64893754
103MELK0.62711107
104PIM20.61813023
105PLK10.61543600
106SGK2230.60779604
107SGK4940.60779604
108ATR0.60614963
109BCKDK0.60559444
110CSNK1G30.60052168
111STK390.59797558
112NME20.58971995
113TBK10.58724580
114MYLK0.58716702
115CHEK20.58301528
116ZAK0.57352820
117PIM10.56300082
118IKBKB0.53568635
119MAP4K10.52553697
120BRSK10.52154811
121PRKAA20.51254719
122CDC70.51025471
123CSNK1G20.51003395
124ATM0.50560449
125PLK40.50453631
126LCK0.48676701
127CDK90.48489943
128LIMK10.48022978
129CAMK2A0.47961366
130MAP2K60.46423949
131IGF1R0.46089387
132SYK0.44947406
133CDK40.43880512
134ABL10.43465791
135EPHB10.43282247
136TTK0.42183624
137PTK2B0.42093100
138MAP3K120.41430447
139ITK0.40696786
140PASK0.39365210
141ADRBK20.39293630
142CSNK1A10.39193385
143FGFR20.37991163
144CSNK1A1L0.37415031
145CSNK2A10.37208783
146GRK50.35608610
147PRKG10.34529421
148PRKCI0.33103692
149CSNK1D0.30809631
150FGFR10.30314147

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.44072574
2Oxidative phosphorylation_Homo sapiens_hsa001902.73906218
3Proteasome_Homo sapiens_hsa030502.57320188
4Parkinsons disease_Homo sapiens_hsa050122.24883495
5Selenocompound metabolism_Homo sapiens_hsa004502.17850807
6Basal transcription factors_Homo sapiens_hsa030222.14974882
7Homologous recombination_Homo sapiens_hsa034402.00231032
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98308558
9Phototransduction_Homo sapiens_hsa047441.93185153
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90981828
11Propanoate metabolism_Homo sapiens_hsa006401.88680743
12Arachidonic acid metabolism_Homo sapiens_hsa005901.87983900
13Fanconi anemia pathway_Homo sapiens_hsa034601.85460528
14Cell cycle_Homo sapiens_hsa041101.85130796
15Ether lipid metabolism_Homo sapiens_hsa005651.77752147
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.76834323
17Linoleic acid metabolism_Homo sapiens_hsa005911.76290469
18Nitrogen metabolism_Homo sapiens_hsa009101.73310914
19Vitamin B6 metabolism_Homo sapiens_hsa007501.72509935
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72398044
21Other glycan degradation_Homo sapiens_hsa005111.71614848
22Steroid biosynthesis_Homo sapiens_hsa001001.70218322
23Pentose phosphate pathway_Homo sapiens_hsa000301.66654814
24Huntingtons disease_Homo sapiens_hsa050161.64585791
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.63635950
26Sphingolipid metabolism_Homo sapiens_hsa006001.62721677
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61405475
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.60449880
29One carbon pool by folate_Homo sapiens_hsa006701.59552438
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58984310
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57838773
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57668486
33Glutathione metabolism_Homo sapiens_hsa004801.55644582
34Pyrimidine metabolism_Homo sapiens_hsa002401.54695967
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.51924094
36DNA replication_Homo sapiens_hsa030301.50482186
37Malaria_Homo sapiens_hsa051441.49137000
38Butanoate metabolism_Homo sapiens_hsa006501.46263262
39Circadian rhythm_Homo sapiens_hsa047101.44224479
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43866149
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.42462794
42Histidine metabolism_Homo sapiens_hsa003401.41416702
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39484411
44Alzheimers disease_Homo sapiens_hsa050101.39396321
45Chemical carcinogenesis_Homo sapiens_hsa052041.39379973
46Nucleotide excision repair_Homo sapiens_hsa034201.38782199
47Herpes simplex infection_Homo sapiens_hsa051681.37488550
48RNA degradation_Homo sapiens_hsa030181.35131826
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34312724
50Tryptophan metabolism_Homo sapiens_hsa003801.33483511
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31166270
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30904759
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28472110
54Protein export_Homo sapiens_hsa030601.25617473
55Folate biosynthesis_Homo sapiens_hsa007901.24508868
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.21755200
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20489582
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18763967
59NF-kappa B signaling pathway_Homo sapiens_hsa040641.15868547
60Staphylococcus aureus infection_Homo sapiens_hsa051501.13939075
61Peroxisome_Homo sapiens_hsa041461.13697071
62Primary bile acid biosynthesis_Homo sapiens_hsa001201.13184787
63Sulfur relay system_Homo sapiens_hsa041221.11503313
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06301016
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05816706
66Nicotine addiction_Homo sapiens_hsa050331.05327870
67Purine metabolism_Homo sapiens_hsa002301.04831271
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03613467
69Cardiac muscle contraction_Homo sapiens_hsa042601.03134632
70Mismatch repair_Homo sapiens_hsa034301.00351103
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.99621547
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99572543
73Vitamin digestion and absorption_Homo sapiens_hsa049770.98253185
74Measles_Homo sapiens_hsa051620.96282545
75Leishmaniasis_Homo sapiens_hsa051400.95301222
76Base excision repair_Homo sapiens_hsa034100.93163659
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93008341
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92643948
79Arginine and proline metabolism_Homo sapiens_hsa003300.92306396
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.91288294
81Spliceosome_Homo sapiens_hsa030400.90719395
82Ribosome_Homo sapiens_hsa030100.90065915
83Retinol metabolism_Homo sapiens_hsa008300.88955987
84RNA transport_Homo sapiens_hsa030130.88674902
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.88244412
86Complement and coagulation cascades_Homo sapiens_hsa046100.84891751
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83555254
88p53 signaling pathway_Homo sapiens_hsa041150.80299414
89Regulation of autophagy_Homo sapiens_hsa041400.78924611
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78655071
91Fatty acid elongation_Homo sapiens_hsa000620.76433941
92Non-homologous end-joining_Homo sapiens_hsa034500.75138778
93Olfactory transduction_Homo sapiens_hsa047400.74839282
94Taste transduction_Homo sapiens_hsa047420.74406359
95Hematopoietic cell lineage_Homo sapiens_hsa046400.72447855
96Pyruvate metabolism_Homo sapiens_hsa006200.72275243
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70427609
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70352174
99Basal cell carcinoma_Homo sapiens_hsa052170.69212467
100Collecting duct acid secretion_Homo sapiens_hsa049660.69088849
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.67700944
102Hepatitis B_Homo sapiens_hsa051610.66282903
103Hepatitis C_Homo sapiens_hsa051600.64916563
104Influenza A_Homo sapiens_hsa051640.63699480
105Fatty acid degradation_Homo sapiens_hsa000710.63693248
106Hedgehog signaling pathway_Homo sapiens_hsa043400.62934793
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61810241
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61754327
109Morphine addiction_Homo sapiens_hsa050320.61156453
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58802329
111GABAergic synapse_Homo sapiens_hsa047270.56433643
112Caffeine metabolism_Homo sapiens_hsa002320.55692567
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55691184
114ABC transporters_Homo sapiens_hsa020100.54946621
115Lysosome_Homo sapiens_hsa041420.54726157
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54625619
117Circadian entrainment_Homo sapiens_hsa047130.53975777
118beta-Alanine metabolism_Homo sapiens_hsa004100.52435125
119Fatty acid metabolism_Homo sapiens_hsa012120.50975091
120Small cell lung cancer_Homo sapiens_hsa052220.50842526
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48632154
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47518837
123Serotonergic synapse_Homo sapiens_hsa047260.47256099
124Hippo signaling pathway_Homo sapiens_hsa043900.46572632
125Pertussis_Homo sapiens_hsa051330.45650857
126Fat digestion and absorption_Homo sapiens_hsa049750.44918631
127N-Glycan biosynthesis_Homo sapiens_hsa005100.44883261
128TGF-beta signaling pathway_Homo sapiens_hsa043500.44755327
129Fatty acid biosynthesis_Homo sapiens_hsa000610.44752358
130Glutamatergic synapse_Homo sapiens_hsa047240.44011555
131Epstein-Barr virus infection_Homo sapiens_hsa051690.42863533
132Metabolic pathways_Homo sapiens_hsa011000.41908521
133Rheumatoid arthritis_Homo sapiens_hsa053230.41820787
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41186494
135Oocyte meiosis_Homo sapiens_hsa041140.40699483
136PPAR signaling pathway_Homo sapiens_hsa033200.40428607
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40189572
138Insulin secretion_Homo sapiens_hsa049110.38391519
139Osteoclast differentiation_Homo sapiens_hsa043800.38031459
140Platelet activation_Homo sapiens_hsa046110.37876514
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.37609895
142B cell receptor signaling pathway_Homo sapiens_hsa046620.36459870
143Sulfur metabolism_Homo sapiens_hsa009200.35841276
144Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33537442

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