ARSF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the sulfatase family, and more specifically, the arylsulfatase subfamily. Members of the subfamily share similarity in sequence and splice sites, and are clustered together on chromosome X, suggesting that they are derived from recent gene duplication events. Sulfatases are essential for the correct composition of bone and cartilage matrix. The activity of this protein, unlike that of arylsulfatase E, is not inhibited by warfarin. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1platelet dense granule organization (GO:0060155)4.55718169
2response to pheromone (GO:0019236)4.38895115
3positive regulation of oligodendrocyte differentiation (GO:0048714)4.38781122
4regulation of sarcomere organization (GO:0060297)4.10717635
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.80559359
6tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.79807157
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.79807157
8preassembly of GPI anchor in ER membrane (GO:0016254)3.50703139
9inositol phosphate catabolic process (GO:0071545)3.48139593
10epithelial cilium movement (GO:0003351)3.45577559
11DNA deamination (GO:0045006)3.39909439
12detection of light stimulus involved in sensory perception (GO:0050962)3.23230833
13detection of light stimulus involved in visual perception (GO:0050908)3.23230833
14protein localization to cilium (GO:0061512)3.18648023
15somite rostral/caudal axis specification (GO:0032525)3.16726084
16behavioral response to nicotine (GO:0035095)3.15148156
17regulation of neurotransmitter uptake (GO:0051580)3.13974095
18piRNA metabolic process (GO:0034587)3.11634363
19phosphorylated carbohydrate dephosphorylation (GO:0046838)3.05154577
20inositol phosphate dephosphorylation (GO:0046855)3.05154577
21polyol catabolic process (GO:0046174)3.04579029
22glycosphingolipid biosynthetic process (GO:0006688)3.03228575
23axoneme assembly (GO:0035082)3.01794461
24cell wall macromolecule metabolic process (GO:0044036)2.99610317
25water-soluble vitamin biosynthetic process (GO:0042364)2.97067248
26regulation of glucokinase activity (GO:0033131)2.96752865
27regulation of hexokinase activity (GO:1903299)2.96752865
28presynaptic membrane assembly (GO:0097105)2.96368611
29fucose catabolic process (GO:0019317)2.96219436
30L-fucose metabolic process (GO:0042354)2.96219436
31L-fucose catabolic process (GO:0042355)2.96219436
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95701441
33GPI anchor metabolic process (GO:0006505)2.95309314
34C4-dicarboxylate transport (GO:0015740)2.94980752
35cytochrome complex assembly (GO:0017004)2.93205002
36proline transport (GO:0015824)2.93069554
37intraciliary transport (GO:0042073)2.88423567
38protein complex biogenesis (GO:0070271)2.87838224
39cilium movement (GO:0003341)2.87692976
40S-adenosylmethionine metabolic process (GO:0046500)2.87549131
41regulation of cilium movement (GO:0003352)2.84073619
42respiratory chain complex IV assembly (GO:0008535)2.81232212
43neuron cell-cell adhesion (GO:0007158)2.81013764
44C-terminal protein lipidation (GO:0006501)2.80883424
45cellular ketone body metabolic process (GO:0046950)2.77618634
46aggressive behavior (GO:0002118)2.75056637
47postsynaptic membrane organization (GO:0001941)2.73796723
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73045056
49negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72895363
50C-terminal protein amino acid modification (GO:0018410)2.72376151
51establishment of protein localization to Golgi (GO:0072600)2.72190636
52phosphatidylinositol acyl-chain remodeling (GO:0036149)2.71429054
53tachykinin receptor signaling pathway (GO:0007217)2.71128615
54cilium morphogenesis (GO:0060271)2.71103057
55presynaptic membrane organization (GO:0097090)2.68769623
56microtubule depolymerization (GO:0007019)2.67535457
57cilium organization (GO:0044782)2.66801219
58detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.66383510
59L-methionine salvage (GO:0071267)2.66378239
60L-methionine biosynthetic process (GO:0071265)2.66378239
61amino acid salvage (GO:0043102)2.66378239
62cilium assembly (GO:0042384)2.63807895
63glycolipid biosynthetic process (GO:0009247)2.63034745
64photoreceptor cell maintenance (GO:0045494)2.60813947
65kynurenine metabolic process (GO:0070189)2.59942327
66GPI anchor biosynthetic process (GO:0006506)2.59765553
67mannosylation (GO:0097502)2.59455551
68protein targeting to Golgi (GO:0000042)2.59082346
69protein polyglutamylation (GO:0018095)2.58583934
70regulation of transmission of nerve impulse (GO:0051969)2.57216023
71behavioral response to ethanol (GO:0048149)2.54655376
72ketone body metabolic process (GO:1902224)2.54508360
73protein K11-linked deubiquitination (GO:0035871)2.53824183
74anterograde synaptic vesicle transport (GO:0048490)2.53008830
75positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.52404254
76gamma-aminobutyric acid transport (GO:0015812)2.52073786
77dopamine transport (GO:0015872)2.50727830
78atrial cardiac muscle cell action potential (GO:0086014)2.50156636
79negative regulation of telomere maintenance (GO:0032205)2.48331561
80calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.47871903
81alanine transport (GO:0032328)2.47561462
82positive regulation of glycolytic process (GO:0045821)2.47254479
83detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.46928509
84negative regulation of JUN kinase activity (GO:0043508)2.46631114
85coenzyme catabolic process (GO:0009109)2.46610279
86cell wall macromolecule catabolic process (GO:0016998)2.46288439
87retinal cone cell development (GO:0046549)2.46139423
88methionine biosynthetic process (GO:0009086)2.43807682
89protein localization to synapse (GO:0035418)2.42879987
90pyrimidine nucleobase catabolic process (GO:0006208)2.41363265
91neural tube formation (GO:0001841)2.41113297
92mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.39803387
93mitochondrial respiratory chain complex I assembly (GO:0032981)2.39803387
94NADH dehydrogenase complex assembly (GO:0010257)2.39803387
95indolalkylamine metabolic process (GO:0006586)2.39609072
96regulation of feeding behavior (GO:0060259)2.38388770
97mitochondrial respiratory chain complex assembly (GO:0033108)2.37307732
98positive regulation of fatty acid transport (GO:2000193)2.36625702
99nucleobase catabolic process (GO:0046113)2.35342506
100cornea development in camera-type eye (GO:0061303)2.34203662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.89373524
2IGF1R_20145208_ChIP-Seq_DFB_Human3.43169522
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00749726
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.84651889
5GBX2_23144817_ChIP-Seq_PC3_Human2.82612045
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66572943
7FUS_26573619_Chip-Seq_HEK293_Human2.49048948
8VDR_22108803_ChIP-Seq_LS180_Human2.39663209
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29817941
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18133037
11TAF15_26573619_Chip-Seq_HEK293_Human2.16369747
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.14994064
13P300_19829295_ChIP-Seq_ESCs_Human2.13970174
14IRF1_19129219_ChIP-ChIP_H3396_Human2.12161933
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03372126
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99814700
17EZH2_22144423_ChIP-Seq_EOC_Human1.99644718
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95772161
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85059178
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75863855
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73031891
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72694144
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.70842113
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68700582
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.67539591
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63225998
27EWS_26573619_Chip-Seq_HEK293_Human1.62418755
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62264667
29ER_23166858_ChIP-Seq_MCF-7_Human1.61130866
30AR_25329375_ChIP-Seq_VCAP_Human1.59403944
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59367892
32SMAD4_21799915_ChIP-Seq_A2780_Human1.58511038
33CBP_20019798_ChIP-Seq_JUKART_Human1.56377397
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56377397
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55468650
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.55146451
37TP53_22573176_ChIP-Seq_HFKS_Human1.55023251
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52641302
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.46536658
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43744374
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42678297
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.42507471
43KLF5_20875108_ChIP-Seq_MESCs_Mouse1.41891707
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40490923
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40170190
46NANOG_19829295_ChIP-Seq_ESCs_Human1.38939930
47SOX2_19829295_ChIP-Seq_ESCs_Human1.38939930
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.38227623
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37884930
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.37575302
51FLI1_21867929_ChIP-Seq_TH2_Mouse1.36606183
52STAT3_23295773_ChIP-Seq_U87_Human1.36370883
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34949869
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33373167
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33010448
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32526763
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31826065
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.30270865
59TCF4_23295773_ChIP-Seq_U87_Human1.29774136
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.28875246
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28875246
62TCF4_22108803_ChIP-Seq_LS180_Human1.28718279
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28035034
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27555912
65BCAT_22108803_ChIP-Seq_LS180_Human1.27211050
66HTT_18923047_ChIP-ChIP_STHdh_Human1.23143044
67RNF2_27304074_Chip-Seq_NSC_Mouse1.23102387
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23014284
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.22070972
70REST_21632747_ChIP-Seq_MESCs_Mouse1.21749064
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21305481
72AR_20517297_ChIP-Seq_VCAP_Human1.20258653
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19367625
74ELK1_19687146_ChIP-ChIP_HELA_Human1.17505121
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.16511928
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15333251
77NCOR_22424771_ChIP-Seq_293T_Human1.15108476
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14864024
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.14735717
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14692462
81RUNX2_22187159_ChIP-Seq_PCA_Human1.13754485
82TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12940528
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12095972
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11582372
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11519923
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.10943921
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.08995954
88MYC_18940864_ChIP-ChIP_HL60_Human1.08366891
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05835411
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.05719513
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05292147
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05186789
93P53_22387025_ChIP-Seq_ESCs_Mouse1.04669179
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.02825285
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02259385
96REST_18959480_ChIP-ChIP_MESCs_Mouse1.01751259
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01312643
98STAT3_18555785_Chip-Seq_ESCs_Mouse0.99646338
99VDR_23849224_ChIP-Seq_CD4+_Human0.99265711
100AR_21572438_ChIP-Seq_LNCaP_Human0.98843549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology2.94734630
2MP0003880_abnormal_central_pattern2.94119012
3MP0008877_abnormal_DNA_methylation2.78240190
4MP0005551_abnormal_eye_electrophysiolog2.55926666
5MP0005645_abnormal_hypothalamus_physiol2.48621493
6MP0003195_calcinosis2.47326977
7MP0002234_abnormal_pharynx_morphology2.37415689
8MP0003787_abnormal_imprinting2.31499496
9MP0003011_delayed_dark_adaptation2.25178560
10MP0006072_abnormal_retinal_apoptosis2.23786019
11MP0001968_abnormal_touch/_nociception2.12098324
12MP0005646_abnormal_pituitary_gland2.10652715
13MP0002138_abnormal_hepatobiliary_system2.08029048
14MP0008872_abnormal_physiological_respon1.98901139
15MP0005253_abnormal_eye_physiology1.96822520
16MP0009046_muscle_twitch1.96412552
17MP0002736_abnormal_nociception_after1.94094871
18MP0008875_abnormal_xenobiotic_pharmacok1.91256203
19MP0002837_dystrophic_cardiac_calcinosis1.90258087
20MP0001984_abnormal_olfaction1.89373603
21MP0009745_abnormal_behavioral_response1.77382158
22MP0002638_abnormal_pupillary_reflex1.74945883
23MP0001529_abnormal_vocalization1.74650647
24MP0002272_abnormal_nervous_system1.68335611
25MP0002653_abnormal_ependyma_morphology1.67688306
26MP0002909_abnormal_adrenal_gland1.66794200
27MP0004145_abnormal_muscle_electrophysio1.65740565
28MP0001486_abnormal_startle_reflex1.62250927
29MP0005075_abnormal_melanosome_morpholog1.55957875
30MP0003183_abnormal_peptide_metabolism1.53157807
31MP0004270_analgesia1.51080654
32MP0002163_abnormal_gland_morphology1.48960217
33MP0002572_abnormal_emotion/affect_behav1.48240673
34MP0000372_irregular_coat_pigmentation1.48172595
35MP0004142_abnormal_muscle_tone1.48150891
36MP0006292_abnormal_olfactory_placode1.45448979
37MP0002876_abnormal_thyroid_physiology1.45118089
38MP0002735_abnormal_chemical_nociception1.44084190
39MP0005174_abnormal_tail_pigmentation1.44077677
40MP0000631_abnormal_neuroendocrine_gland1.42829140
41MP0004147_increased_porphyrin_level1.41989313
42MP0006276_abnormal_autonomic_nervous1.41339704
43MP0004133_heterotaxia1.40734438
44MP0001501_abnormal_sleep_pattern1.34578255
45MP0005084_abnormal_gallbladder_morpholo1.33910886
46MP0005410_abnormal_fertilization1.31109992
47MP0003635_abnormal_synaptic_transmissio1.27768972
48MP0002095_abnormal_skin_pigmentation1.27606652
49MP0002928_abnormal_bile_duct1.27216670
50MP0002557_abnormal_social/conspecific_i1.26499199
51MP0009780_abnormal_chondrocyte_physiolo1.26200936
52MP0005379_endocrine/exocrine_gland_phen1.24863989
53MP0004043_abnormal_pH_regulation1.23625537
54MP0008995_early_reproductive_senescence1.20465198
55MP0004885_abnormal_endolymph1.19497452
56MP0001970_abnormal_pain_threshold1.19019882
57MP0002751_abnormal_autonomic_nervous1.18735376
58MP0004215_abnormal_myocardial_fiber1.18526995
59MP0000647_abnormal_sebaceous_gland1.18348630
60MP0001764_abnormal_homeostasis1.18289090
61MP0002734_abnormal_mechanical_nocicepti1.16878651
62MP0000427_abnormal_hair_cycle1.16797019
63MP0003567_abnormal_fetal_cardiomyocyte1.16559063
64MP0001905_abnormal_dopamine_level1.13834111
65MP0002063_abnormal_learning/memory/cond1.13036829
66MP0001986_abnormal_taste_sensitivity1.12693783
67MP0005365_abnormal_bile_salt1.11995847
68MP0002064_seizures1.10631972
69MP0001188_hyperpigmentation1.09968162
70MP0003122_maternal_imprinting1.07821443
71MP0001485_abnormal_pinna_reflex1.06152735
72MP0002184_abnormal_innervation1.06105239
73MP0005167_abnormal_blood-brain_barrier1.05075939
74MP0004742_abnormal_vestibular_system1.03689690
75MP0010386_abnormal_urinary_bladder1.02596248
76MP0004924_abnormal_behavior1.01550243
77MP0005386_behavior/neurological_phenoty1.01550243
78MP0004859_abnormal_synaptic_plasticity1.01492403
79MP0002229_neurodegeneration1.01274959
80MP0002733_abnormal_thermal_nociception0.99876635
81MP0005499_abnormal_olfactory_system0.99841530
82MP0005394_taste/olfaction_phenotype0.99841530
83MP0002067_abnormal_sensory_capabilities0.99074220
84MP0005332_abnormal_amino_acid0.98383800
85MP0003137_abnormal_impulse_conducting0.97572079
86MP0000569_abnormal_digit_pigmentation0.97243375
87MP0001502_abnormal_circadian_rhythm0.95257976
88MP0000778_abnormal_nervous_system0.91363171
89MP0001963_abnormal_hearing_physiology0.91359602
90MP0002254_reproductive_system_inflammat0.91308885
91MP0001756_abnormal_urination0.90188945
92MP0006036_abnormal_mitochondrial_physio0.88201795
93MP0001324_abnormal_eye_pigmentation0.88019439
94MP0002139_abnormal_hepatobiliary_system0.87964898
95MP0002277_abnormal_respiratory_mucosa0.87501370
96MP0002090_abnormal_vision0.86313399
97MP0000015_abnormal_ear_pigmentation0.86123700
98MP0005377_hearing/vestibular/ear_phenot0.85524180
99MP0003878_abnormal_ear_physiology0.85524180
100MP0004085_abnormal_heartbeat0.85282369

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.35704700
2Pancreatic fibrosis (HP:0100732)4.09265702
3Molar tooth sign on MRI (HP:0002419)3.87807788
4Abnormality of midbrain morphology (HP:0002418)3.87807788
5True hermaphroditism (HP:0010459)3.84003821
6Nephronophthisis (HP:0000090)3.48111509
7Abnormality of the renal cortex (HP:0011035)3.45483668
8Congenital stationary night blindness (HP:0007642)3.44523614
9Medial flaring of the eyebrow (HP:0010747)3.34286789
10Hyperventilation (HP:0002883)3.18972664
11Renal cortical cysts (HP:0000803)3.07580812
12Aplasia/Hypoplasia of the fovea (HP:0008060)3.06431052
13Hypoplasia of the fovea (HP:0007750)3.06431052
14Abnormal biliary tract physiology (HP:0012439)3.00324758
15Bile duct proliferation (HP:0001408)3.00324758
16Abnormality of the renal medulla (HP:0100957)2.99614323
17Intestinal atresia (HP:0011100)2.81509135
18Abnormal rod and cone electroretinograms (HP:0008323)2.78580403
19Abnormal drinking behavior (HP:0030082)2.76430933
20Polydipsia (HP:0001959)2.76430933
21Nephrogenic diabetes insipidus (HP:0009806)2.75798978
22Cystic liver disease (HP:0006706)2.73093176
23Ketoacidosis (HP:0001993)2.71716202
24Attenuation of retinal blood vessels (HP:0007843)2.71649165
25Focal motor seizures (HP:0011153)2.70768633
26Abnormality of the fovea (HP:0000493)2.65066199
27Tubular atrophy (HP:0000092)2.65007123
28Chronic hepatic failure (HP:0100626)2.62685817
29Hypothermia (HP:0002045)2.59147694
30Methylmalonic acidemia (HP:0002912)2.54927225
31Hemiparesis (HP:0001269)2.52532370
323-Methylglutaconic aciduria (HP:0003535)2.51683835
33Colon cancer (HP:0003003)2.49587948
34Lissencephaly (HP:0001339)2.46373759
35Decreased central vision (HP:0007663)2.44255026
36Gait imbalance (HP:0002141)2.43760633
37Pancreatic islet-cell hyperplasia (HP:0004510)2.42549371
38Large for gestational age (HP:0001520)2.40334147
39Mitochondrial inheritance (HP:0001427)2.36669528
40Congenital primary aphakia (HP:0007707)2.33853528
41Acute necrotizing encephalopathy (HP:0006965)2.33237763
42Progressive macrocephaly (HP:0004481)2.32777898
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.28318060
44Increased CSF lactate (HP:0002490)2.25120716
45Sclerocornea (HP:0000647)2.21919851
46Ketosis (HP:0001946)2.21364902
47Occipital encephalocele (HP:0002085)2.19474468
48Aplasia/hypoplasia of the uterus (HP:0008684)2.17835528
49Furrowed tongue (HP:0000221)2.15703852
50Hepatic necrosis (HP:0002605)2.13878680
51Hyperinsulinemic hypoglycemia (HP:0000825)2.13712996
52Polyuria (HP:0000103)2.12217097
53Febrile seizures (HP:0002373)2.11372870
54Hypoglycemic coma (HP:0001325)2.09319165
55Hyperglycinemia (HP:0002154)2.09011452
56Severe visual impairment (HP:0001141)2.07485784
57Hepatocellular necrosis (HP:0001404)2.07466615
58Hyperglycinuria (HP:0003108)2.07174801
59Hypomagnesemia (HP:0002917)2.07027726
60Increased hepatocellular lipid droplets (HP:0006565)2.07002792
61Acute encephalopathy (HP:0006846)2.04028858
62Rib fusion (HP:0000902)2.04014585
63Methylmalonic aciduria (HP:0012120)1.99223255
64Abnormal mitochondria in muscle tissue (HP:0008316)1.98523311
65Postaxial foot polydactyly (HP:0001830)1.96268212
66Gaze-evoked nystagmus (HP:0000640)1.94335724
67Abnormality of the pancreatic islet cells (HP:0006476)1.94110562
68Abnormality of endocrine pancreas physiology (HP:0012093)1.94110562
69Lipid accumulation in hepatocytes (HP:0006561)1.93558138
70Male pseudohermaphroditism (HP:0000037)1.93177892
71Abnormality of macular pigmentation (HP:0008002)1.92352843
72Genital tract atresia (HP:0001827)1.90811651
73Hypoglycemic seizures (HP:0002173)1.90001415
74Anencephaly (HP:0002323)1.89758533
75Abolished electroretinogram (ERG) (HP:0000550)1.89224395
76Congenital hepatic fibrosis (HP:0002612)1.87993115
77Polyphagia (HP:0002591)1.87697526
78Prolonged partial thromboplastin time (HP:0003645)1.86705040
79Tachypnea (HP:0002789)1.85911412
80Abnormality of vitamin B metabolism (HP:0004340)1.84729479
81Bony spicule pigmentary retinopathy (HP:0007737)1.83505429
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83194711
83Increased corneal curvature (HP:0100692)1.82850366
84Keratoconus (HP:0000563)1.82850366
85Abnormality of glycine metabolism (HP:0010895)1.82822040
86Abnormality of serine family amino acid metabolism (HP:0010894)1.82822040
87Focal seizures (HP:0007359)1.80686958
88Albinism (HP:0001022)1.80007453
89Type II lissencephaly (HP:0007260)1.78336365
90Aplasia/Hypoplasia of the spleen (HP:0010451)1.78094128
91Postaxial hand polydactyly (HP:0001162)1.77991459
92Vaginal atresia (HP:0000148)1.77616814
93Dyskinesia (HP:0100660)1.76404866
94Pachygyria (HP:0001302)1.75853937
95Abnormal urine output (HP:0012590)1.73412687
96Aplasia/Hypoplasia of the macula (HP:0008059)1.73165339
97Broad-based gait (HP:0002136)1.73026347
98Asplenia (HP:0001746)1.72987034
99Abnormality of urine glucose concentration (HP:0011016)1.71313840
100Glycosuria (HP:0003076)1.71313840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.35643152
2MAP4K24.14293382
3MUSK3.27929709
4INSRR3.11687008
5CASK3.08091627
6WNK32.94395942
7MAPK132.63067408
8STK38L2.26962950
9VRK22.14151271
10MARK12.13751446
11MAP3K42.11581863
12TAOK31.95428705
13ADRBK21.95271061
14TRIM281.93912037
15PINK11.92609925
16NUAK11.79032797
17MST41.69409885
18TAF11.65320992
19CSNK1G21.63911002
20OXSR11.57900750
21EPHA41.49727631
22GRK11.49343507
23WNK41.46319852
24MAP2K71.45943831
25TXK1.45333920
26CAMKK21.38381668
27CSNK1G31.32998528
28BCR1.30081103
29BMPR1B1.29374025
30NTRK31.28830872
31CSNK1G11.27379404
32STK391.23321793
33MAP3K121.07774045
34MAP2K61.07295839
35DYRK1A1.06527333
36DAPK21.06192233
37PAK31.06084330
38CSNK1A1L1.04911173
39VRK11.00365520
40PHKG20.98390601
41PHKG10.98390601
42MAP2K40.93387210
43PLK20.93081863
44ADRBK10.92343669
45ZAK0.88122876
46EPHA30.86403793
47TNIK0.85770905
48DYRK20.82964246
49PRKCE0.82143709
50FER0.80778103
51AKT30.76381106
52MKNK20.75753468
53PRKCG0.73737996
54DYRK1B0.70618550
55TIE10.66301480
56DYRK30.65274351
57CAMK2B0.63591962
58PKN10.63362814
59UHMK10.63053818
60SRPK10.62789177
61CAMK2A0.62388330
62PTK2B0.61057563
63NTRK20.59740098
64FLT30.58964265
65STK160.56844198
66CAMK2D0.55592885
67FGFR20.52971892
68ERBB30.50986544
69IKBKE0.50617618
70GRK50.46873206
71PRKACA0.43882298
72TLK10.43451040
73CSNK1A10.42657599
74IRAK10.42076908
75DAPK10.41074220
76CAMK40.40383796
77MINK10.39539584
78PLK30.38623132
79RPS6KA40.36917078
80CAMK10.36647073
81CSNK1D0.36523460
82SGK20.36492125
83PRKCI0.35728384
84BRSK20.35595698
85PRKCQ0.34356607
86IRAK40.32646066
87MAPKAPK50.32313509
88MKNK10.31079289
89PIK3CG0.30661707
90PRKG10.30514712
91STK380.30118051
92PRKCA0.30045490
93IKBKB0.29604882
94SIK30.27893932
95MAP3K50.27333997
96ACVR1B0.26762475
97STK110.26691278
98KDR0.26496477
99EIF2AK10.26416787
100PRKACB0.26057518

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.99565449
2Butanoate metabolism_Homo sapiens_hsa006502.93831222
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.89916103
4Phototransduction_Homo sapiens_hsa047442.80721810
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.71702998
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50824280
7Linoleic acid metabolism_Homo sapiens_hsa005912.47709219
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.40883548
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.30085279
10Oxidative phosphorylation_Homo sapiens_hsa001902.19181225
11Protein export_Homo sapiens_hsa030602.14413874
12Ether lipid metabolism_Homo sapiens_hsa005651.88888358
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84362770
14Propanoate metabolism_Homo sapiens_hsa006401.83271763
15Nicotine addiction_Homo sapiens_hsa050331.74936075
16Tryptophan metabolism_Homo sapiens_hsa003801.59872798
17Taste transduction_Homo sapiens_hsa047421.57243638
18Collecting duct acid secretion_Homo sapiens_hsa049661.55651941
19Caffeine metabolism_Homo sapiens_hsa002321.52759359
20Parkinsons disease_Homo sapiens_hsa050121.51299189
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47630296
22Homologous recombination_Homo sapiens_hsa034401.43072465
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.41940912
24One carbon pool by folate_Homo sapiens_hsa006701.41175586
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39161092
26RNA polymerase_Homo sapiens_hsa030201.35622806
27Fatty acid elongation_Homo sapiens_hsa000621.34065991
28Peroxisome_Homo sapiens_hsa041461.32598871
29Nitrogen metabolism_Homo sapiens_hsa009101.24287914
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23301310
31Insulin secretion_Homo sapiens_hsa049111.23196291
32Fatty acid degradation_Homo sapiens_hsa000711.22926755
33Fanconi anemia pathway_Homo sapiens_hsa034601.22858312
34Basal transcription factors_Homo sapiens_hsa030221.21930686
35Arachidonic acid metabolism_Homo sapiens_hsa005901.19111658
36Type I diabetes mellitus_Homo sapiens_hsa049401.16061054
37Circadian rhythm_Homo sapiens_hsa047101.14370977
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14331639
39Chemical carcinogenesis_Homo sapiens_hsa052041.12719455
40Olfactory transduction_Homo sapiens_hsa047401.12259132
41RNA degradation_Homo sapiens_hsa030181.11298063
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09065514
43beta-Alanine metabolism_Homo sapiens_hsa004101.08562304
44Retinol metabolism_Homo sapiens_hsa008301.08534709
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.05159719
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04543975
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01093115
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.99867577
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.98540258
50GABAergic synapse_Homo sapiens_hsa047270.97542767
51Huntingtons disease_Homo sapiens_hsa050160.97181957
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97148337
53Morphine addiction_Homo sapiens_hsa050320.93576922
54Glutamatergic synapse_Homo sapiens_hsa047240.93228639
55ABC transporters_Homo sapiens_hsa020100.92471797
56Alzheimers disease_Homo sapiens_hsa050100.88528437
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.87251026
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86348003
59Histidine metabolism_Homo sapiens_hsa003400.84683456
60Circadian entrainment_Homo sapiens_hsa047130.84588418
61Regulation of autophagy_Homo sapiens_hsa041400.79614281
62Proteasome_Homo sapiens_hsa030500.78801762
63Ovarian steroidogenesis_Homo sapiens_hsa049130.77498815
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76388048
65Fat digestion and absorption_Homo sapiens_hsa049750.76019055
66Fatty acid metabolism_Homo sapiens_hsa012120.75728392
67Cardiac muscle contraction_Homo sapiens_hsa042600.75631862
68Synaptic vesicle cycle_Homo sapiens_hsa047210.75133094
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72009087
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71825853
71Selenocompound metabolism_Homo sapiens_hsa004500.71631966
72Amphetamine addiction_Homo sapiens_hsa050310.71221358
73Metabolic pathways_Homo sapiens_hsa011000.71064007
74Purine metabolism_Homo sapiens_hsa002300.69721714
75Serotonergic synapse_Homo sapiens_hsa047260.69605062
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.66807338
77Renin secretion_Homo sapiens_hsa049240.66035765
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62828380
79Salivary secretion_Homo sapiens_hsa049700.60415357
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.59135971
81Dopaminergic synapse_Homo sapiens_hsa047280.58596917
82Folate biosynthesis_Homo sapiens_hsa007900.58331134
83Primary immunodeficiency_Homo sapiens_hsa053400.57421605
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51385655
85Rheumatoid arthritis_Homo sapiens_hsa053230.48645121
86Pyruvate metabolism_Homo sapiens_hsa006200.47541207
87Vitamin B6 metabolism_Homo sapiens_hsa007500.47510427
88Calcium signaling pathway_Homo sapiens_hsa040200.46153484
89Glycerolipid metabolism_Homo sapiens_hsa005610.45602771
90Asthma_Homo sapiens_hsa053100.43581111
91Autoimmune thyroid disease_Homo sapiens_hsa053200.43277803
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42888682
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41245037
94Pyrimidine metabolism_Homo sapiens_hsa002400.41165748
95Sphingolipid metabolism_Homo sapiens_hsa006000.38965899
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38296690
97Glutathione metabolism_Homo sapiens_hsa004800.38214700
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38074175
99Arginine and proline metabolism_Homo sapiens_hsa003300.37648028
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35787524

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