ARRDC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skin morphogenesis (GO:0043589)4.25249890
2keratinization (GO:0031424)4.14220319
3oligosaccharide catabolic process (GO:0009313)3.77190163
4positive regulation of p38MAPK cascade (GO:1900745)3.76782573
5response to muramyl dipeptide (GO:0032495)3.60738370
6positive regulation of cellular amide metabolic process (GO:0034250)3.50932294
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.47734853
8positive regulation by symbiont of host defense response (GO:0052509)3.27284425
9modulation by symbiont of host defense response (GO:0052031)3.27284425
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.27284425
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.27284425
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.27284425
13modulation by symbiont of host immune response (GO:0052553)3.27284425
14suckling behavior (GO:0001967)3.20812964
15auditory receptor cell differentiation (GO:0042491)3.20401577
16detection of molecule of bacterial origin (GO:0032490)3.18793473
17macroautophagy (GO:0016236)3.16662159
18low-density lipoprotein particle clearance (GO:0034383)3.16634065
19positive regulation of heat generation (GO:0031652)3.10195184
20neutrophil activation involved in immune response (GO:0002283)3.08971261
21regulation of fever generation (GO:0031620)3.06244072
22positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.03887477
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98351123
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98351123
25regulation of cholesterol storage (GO:0010885)2.98258539
26antigen processing and presentation of endogenous antigen (GO:0019883)2.94004140
27interleukin-6-mediated signaling pathway (GO:0070102)2.92166681
28establishment of skin barrier (GO:0061436)2.91907014
29hemidesmosome assembly (GO:0031581)2.90976924
30positive regulation of interferon-alpha production (GO:0032727)2.90535286
31lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90507739
32macrophage activation involved in immune response (GO:0002281)2.90448359
33wound healing, spreading of epidermal cells (GO:0035313)2.85813246
34Notch signaling involved in heart development (GO:0061314)2.85281157
35neuron remodeling (GO:0016322)2.84536792
36hydrogen peroxide biosynthetic process (GO:0050665)2.84204347
37interferon-gamma secretion (GO:0072643)2.82948548
38growth hormone receptor signaling pathway (GO:0060396)2.82828067
39positive regulation of natural killer cell differentiation (GO:0032825)2.82436800
40response to peptidoglycan (GO:0032494)2.82323940
41production of molecular mediator involved in inflammatory response (GO:0002532)2.81497202
42regulation of heterotypic cell-cell adhesion (GO:0034114)2.76421266
43regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.75932079
44positive regulation of chemokine biosynthetic process (GO:0045080)2.74945009
45negative regulation of lipid storage (GO:0010888)2.74529688
46regulation of water loss via skin (GO:0033561)2.74359818
47peptide catabolic process (GO:0043171)2.73533451
48positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.73117407
49regulation of interleukin-12 biosynthetic process (GO:0045075)2.72577783
50positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.72030869
51regulation of extracellular matrix disassembly (GO:0010715)2.71156734
52positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.70707306
53regulation of interferon-alpha production (GO:0032647)2.70132101
54monocyte chemotaxis (GO:0002548)2.66648304
55regulation of podosome assembly (GO:0071801)2.65822378
56cytokine secretion (GO:0050663)2.65552617
57response to interferon-alpha (GO:0035455)2.64821371
58granulocyte activation (GO:0036230)2.63832689
59apoptotic cell clearance (GO:0043277)2.62621159
60epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61899960
61response to host (GO:0075136)2.60632920
62response to host defenses (GO:0052200)2.60632920
63response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.60632920
64cell adhesion mediated by integrin (GO:0033627)2.57628212
65regulation of p38MAPK cascade (GO:1900744)2.57322242
66nerve growth factor signaling pathway (GO:0038180)2.52750533
67hair cell differentiation (GO:0035315)2.52576434
68Golgi to endosome transport (GO:0006895)2.52010388
69regulation of integrin activation (GO:0033623)2.49458163
70regulation of heat generation (GO:0031650)2.48767367
71glycosphingolipid catabolic process (GO:0046479)2.47548234
72T-helper 1 type immune response (GO:0042088)2.47416448
73detection of external biotic stimulus (GO:0098581)2.47232057
74response to host immune response (GO:0052572)2.46747440
75response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.46747440
76regulation of mononuclear cell migration (GO:0071675)2.45424412
77positive regulation of interleukin-12 production (GO:0032735)2.45385890
78axonal fasciculation (GO:0007413)2.45272840
79regulation of transforming growth factor beta1 production (GO:0032908)2.45091200
80NIK/NF-kappaB signaling (GO:0038061)2.44413978
81regulation of activation of Janus kinase activity (GO:0010533)2.44150057
82response to interferon-beta (GO:0035456)2.42523642
83immunoglobulin mediated immune response (GO:0016064)2.41797381
84superoxide anion generation (GO:0042554)2.41438714
85detection of biotic stimulus (GO:0009595)2.41367057
86positive regulation of lipid storage (GO:0010884)2.40784299
87import into cell (GO:0098657)2.39878714
88peptidyl-proline hydroxylation (GO:0019511)2.37538691
89cellular response to growth hormone stimulus (GO:0071378)2.36125821
90positive regulation of interferon-beta production (GO:0032728)2.35534885
91positive regulation of antigen processing and presentation (GO:0002579)2.35195172
92glycolipid catabolic process (GO:0019377)2.34406534
93basement membrane organization (GO:0071711)2.33670050
94neutrophil activation (GO:0042119)2.33555009
95macrophage activation (GO:0042116)2.32652508
96regulation of macrophage cytokine production (GO:0010935)2.32477801
97phagocytosis, recognition (GO:0006910)2.32287451
98intermediate filament organization (GO:0045109)2.31755345
99myeloid cell homeostasis (GO:0002262)2.30965191
100reactive oxygen species biosynthetic process (GO:1903409)2.30832128
101negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.29699151
102barbed-end actin filament capping (GO:0051016)2.28653375
103positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.27945459
104regulation of dendritic cell antigen processing and presentation (GO:0002604)2.27191187
105negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.27105206
106positive regulation of interleukin-6 production (GO:0032755)2.26838060
107regulation of chemokine biosynthetic process (GO:0045073)2.26284435
108response to type I interferon (GO:0034340)2.25810295
109multicellular organismal water homeostasis (GO:0050891)2.25693494
110cellular response to type I interferon (GO:0071357)2.25569969
111type I interferon signaling pathway (GO:0060337)2.25569969
112cellular response to interferon-alpha (GO:0035457)2.25318434
113desmosome organization (GO:0002934)2.24887884
114negative regulation of keratinocyte proliferation (GO:0010839)2.24115348
115eosinophil chemotaxis (GO:0048245)2.23657864
116surfactant homeostasis (GO:0043129)2.23337135
117endodermal cell differentiation (GO:0035987)2.22878761
118negative regulation of viral genome replication (GO:0045071)2.22683205
119embryonic process involved in female pregnancy (GO:0060136)2.22446392
120regulation of transforming growth factor beta2 production (GO:0032909)2.21526001
121glucose 6-phosphate metabolic process (GO:0051156)2.20965716
122positive regulation vascular endothelial growth factor production (GO:0010575)2.20792423
123positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.19697983
124osteoclast differentiation (GO:0030316)2.19680749
125regulation of cAMP-dependent protein kinase activity (GO:2000479)2.19655233
126platelet-derived growth factor receptor signaling pathway (GO:0048008)2.19523816
127embryonic retina morphogenesis in camera-type eye (GO:0060059)2.18562797
128calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.18514044
129xenobiotic catabolic process (GO:0042178)2.18202006
130regulation of natural killer cell differentiation (GO:0032823)2.17980921
131positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.17926049
132JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.17839301
133chemical homeostasis within a tissue (GO:0048875)2.17172426
134astrocyte differentiation (GO:0048708)2.15571828
135long-chain fatty acid biosynthetic process (GO:0042759)2.14534375
136protein hydroxylation (GO:0018126)2.13319559
137keratinocyte differentiation (GO:0030216)2.11987981
138mating behavior (GO:0007617)2.11551055
139ganglioside metabolic process (GO:0001573)2.10941748
140dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.10892653
141vitamin D metabolic process (GO:0042359)2.10325692
142establishment of planar polarity (GO:0001736)2.09678589
143establishment of tissue polarity (GO:0007164)2.09678589
144endocytic recycling (GO:0032456)2.09595868
145ceramide catabolic process (GO:0046514)2.08155077
146dendrite morphogenesis (GO:0048813)2.08118195
147collagen fibril organization (GO:0030199)2.03010848
148protein heterotrimerization (GO:0070208)2.02200777
149germinal center formation (GO:0002467)2.01458315
150regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.01362500
151negative regulation of Rho protein signal transduction (GO:0035024)2.01097627
152collagen catabolic process (GO:0030574)2.00599921
153regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.99864229
154multicellular organismal catabolic process (GO:0044243)1.98553703
155negative regulation of neurotransmitter secretion (GO:0046929)1.98347261
156cellular copper ion homeostasis (GO:0006878)1.96673841
157neuron recognition (GO:0008038)1.96268481
158water homeostasis (GO:0030104)1.95879149
159positive regulation of calcium ion import (GO:0090280)1.95455760
160vesicle transport along microtubule (GO:0047496)1.95317458
161cellular response to fluid shear stress (GO:0071498)1.95196706
162organelle transport along microtubule (GO:0072384)1.95094132
163peptide hormone processing (GO:0016486)1.94297911
164hypotonic response (GO:0006971)1.93507984
165protein targeting to vacuole (GO:0006623)1.93402361
166protein targeting to lysosome (GO:0006622)1.93402361
167establishment of protein localization to vacuole (GO:0072666)1.93402361
168epidermal cell differentiation (GO:0009913)1.92683216
169early endosome to late endosome transport (GO:0045022)1.92378317
170apical protein localization (GO:0045176)1.91950940
171eosinophil migration (GO:0072677)1.90936444
172endothelial cell chemotaxis (GO:0035767)1.90292081
173ionotropic glutamate receptor signaling pathway (GO:0035235)1.90108120
174positive regulation of cholesterol transport (GO:0032376)1.89871720
175positive regulation of sterol transport (GO:0032373)1.89871720
176negative regulation of type 2 immune response (GO:0002829)1.88381325
177regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.87639016
178sphingolipid catabolic process (GO:0030149)1.84935944
179membrane lipid catabolic process (GO:0046466)1.84785769
180response to lipoprotein particle (GO:0055094)1.84158113
181collagen metabolic process (GO:0032963)1.83376071
182eye photoreceptor cell differentiation (GO:0001754)1.82976183
183photoreceptor cell differentiation (GO:0046530)1.82976183
184multicellular organismal macromolecule metabolic process (GO:0044259)1.81805381
185establishment of mitochondrion localization (GO:0051654)1.81401289
186toxin transport (GO:1901998)1.80896762
187adhesion of symbiont to host cell (GO:0044650)1.80605334
188virion attachment to host cell (GO:0019062)1.80605334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.82180127
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.84990317
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.49757999
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.40052994
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.34232112
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.15140939
7CDX2_19796622_ChIP-Seq_MESCs_Mouse3.05385353
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.93529018
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.89908199
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.87709978
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.56372108
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.50147000
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.50147000
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.50147000
15CLOCK_20551151_ChIP-Seq_293T_Human2.48667853
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.37010499
17GBX2_23144817_ChIP-Seq_PC3_Human2.34150902
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30478278
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23823857
20TRIM28_21343339_ChIP-Seq_HEK293_Human2.23445188
21* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.15762073
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08337010
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04863586
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03073303
25* IRF8_27001747_Chip-Seq_BMDM_Mouse1.99591795
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96146492
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.95930775
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.93137521
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91992322
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.91031720
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88005008
32* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.86722791
33* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.86722791
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84840182
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.83874915
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.83364267
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.81304166
38* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.80288626
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77543075
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75467363
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75082922
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72301459
43TAF15_26573619_Chip-Seq_HEK293_Human1.71880728
44* FOXO3_23340844_ChIP-Seq_DLD1_Human1.71571644
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65770377
46TP53_16413492_ChIP-PET_HCT116_Human1.65534855
47* LXR_22158963_ChIP-Seq_LIVER_Mouse1.65162438
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65072284
49* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.63554294
50* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.63554294
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63428729
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61589602
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59320836
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58353885
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.57336563
56SOX2_20726797_ChIP-Seq_SW620_Human1.53523166
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52041207
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51009602
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50495392
60TP53_18474530_ChIP-ChIP_U2OS_Human1.50350233
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.50292570
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49854409
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46795818
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46142083
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45738391
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.45483900
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.44443799
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44035173
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42910733
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41809952
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41363802
72TP63_23658742_ChIP-Seq_EP156T_Human1.37926201
73* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37800580
74ZNF263_19887448_ChIP-Seq_K562_Human1.37265017
75* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37153711
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34772007
77SMAD4_21799915_ChIP-Seq_A2780_Human1.33822278
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33320701
79AHR_22903824_ChIP-Seq_MCF-7_Human1.33037336
80ATF3_27146783_Chip-Seq_COLON_Human1.31781297
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28728161
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28578454
83ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26786826
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24654322
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.24612014
86PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21385411
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20606117
88SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19502042
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17814484
90RACK7_27058665_Chip-Seq_MCF-7_Human1.17203006
91* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17159767
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.16098624
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15443348
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.15210084
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15199541
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15168721
97GATA6_25053715_ChIP-Seq_YYC3_Human1.14915675
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14572958
99TCF7_22412390_ChIP-Seq_EML_Mouse1.12461152
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11922484
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11273090
102IGF1R_20145208_ChIP-Seq_DFB_Human1.11203233
103* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10826593
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.10202468
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10022533
106* GATA4_25053715_ChIP-Seq_YYC3_Human1.09707585
107SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09103098
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08075229
109* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08008777
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07353843
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06988337
112CJUN_26792858_Chip-Seq_BT549_Human1.06708455
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06526124
114MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06152407
115* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05842829
116BRD4_25478319_ChIP-Seq_HGPS_Human1.05775290
117SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05657019
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04801495
119ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03682093
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03679842
121SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02549169
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02467315
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01773013
124P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01063812
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00972334
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00687902
127SMAD3_21741376_ChIP-Seq_HESCs_Human1.00535490
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00040479
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99482208
130SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99333909
131* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99003397
132MAF_26560356_Chip-Seq_TH1_Human0.98894702
133* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98366236
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97456160
135SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97056356
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96016773
137GATA3_24758297_ChIP-Seq_MCF-7_Human0.95553741
138STAT3_23295773_ChIP-Seq_U87_Human0.95196495
139VDR_24763502_ChIP-Seq_THP-1_Human0.95049363
140UBF1/2_26484160_Chip-Seq_HMECs_Human0.94983554
141VDR_24787735_ChIP-Seq_THP-1_Human0.94476085
142P300_19829295_ChIP-Seq_ESCs_Human0.93962418
143* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93949528
144TCF4_18268006_ChIP-ChIP_LS174T_Human0.93821561
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93504780
146KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93500733
147CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93370785
148HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92243931
149ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92044092
150TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91862011
151EED_16625203_ChIP-ChIP_MESCs_Mouse0.91708995
152WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91416072
153RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90733286
154JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90392165
155SMAD4_21741376_ChIP-Seq_HESCs_Human0.90379874
156KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90224325
157CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89629383
158CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89392432
159MYB_26560356_Chip-Seq_TH2_Human0.89303607
160JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89267661
161CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88453739
162* RUNX1_27514584_Chip-Seq_MCF-7_Human0.88416967
163CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88141761
164PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88005826
165NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87669174
166* SOX2_21211035_ChIP-Seq_LN229_Gbm0.87611422
167TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87219570
168CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87199996
169EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86727545
170CBX2_27304074_Chip-Seq_ESCs_Mouse0.86569215
171JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84415040
172GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84392297
173FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84114251
174* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84029926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.93664925
2MP0002254_reproductive_system_inflammat3.52780339
3MP0004270_analgesia2.89854720
4MP0005409_darkened_coat_color2.73759336
5MP0002909_abnormal_adrenal_gland2.73551480
6MP0003705_abnormal_hypodermis_morpholog2.69043744
7MP0010234_abnormal_vibrissa_follicle2.67680649
8MP0003436_decreased_susceptibility_to2.57249461
9MP0000579_abnormal_nail_morphology2.49377495
10MP0010352_gastrointestinal_tract_polyps2.48763912
11MP0003303_peritoneal_inflammation2.34634892
12MP0009785_altered_susceptibility_to2.33768350
13MP0009780_abnormal_chondrocyte_physiolo2.30709725
14MP0003566_abnormal_cell_adhesion2.25966582
15MP0003941_abnormal_skin_development2.22530468
16MP0005076_abnormal_cell_differentiation2.14301068
17MP0000685_abnormal_immune_system2.10267611
18MP0004885_abnormal_endolymph2.09048692
19MP0001835_abnormal_antigen_presentation2.07241440
20MP0003453_abnormal_keratinocyte_physiol2.06071057
21MP0009278_abnormal_bone_marrow2.01537050
22MP0003724_increased_susceptibility_to1.98858091
23MP0006054_spinal_hemorrhage1.89738175
24MP0002148_abnormal_hypersensitivity_rea1.87407063
25MP0001188_hyperpigmentation1.83731153
26MP0001542_abnormal_bone_strength1.82806138
27MP0004947_skin_inflammation1.81581049
28MP0008438_abnormal_cutaneous_collagen1.77681183
29MP0000013_abnormal_adipose_tissue1.72154647
30MP0003329_amyloid_beta_deposits1.70858610
31MP0002419_abnormal_innate_immunity1.70258512
32MP0010386_abnormal_urinary_bladder1.65910737
33MP0003172_abnormal_lysosome_physiology1.65755541
34MP0006082_CNS_inflammation1.65100118
35MP0003448_altered_tumor_morphology1.64856401
36MP0004858_abnormal_nervous_system1.64482396
37MP0005025_abnormal_response_to1.60739504
38MP0003300_gastrointestinal_ulcer1.60227386
39MP0010155_abnormal_intestine_physiology1.58427242
40MP0001533_abnormal_skeleton_physiology1.57520896
41MP0004264_abnormal_extraembryonic_tissu1.55213783
42MP0005023_abnormal_wound_healing1.53040607
43MP0005275_abnormal_skin_tensile1.52402402
44MP0002837_dystrophic_cardiac_calcinosis1.52375062
45MP0003183_abnormal_peptide_metabolism1.51736402
46MP0000858_altered_metastatic_potential1.49073762
47MP0009764_decreased_sensitivity_to1.46578101
48MP0005000_abnormal_immune_tolerance1.45755682
49MP0003191_abnormal_cellular_cholesterol1.42346309
50MP0002796_impaired_skin_barrier1.41864086
51MP0000604_amyloidosis1.41603550
52MP0002896_abnormal_bone_mineralization1.40395034
53MP0009840_abnormal_foam_cell1.40019304
54MP0000343_altered_response_to1.40007709
55MP0001881_abnormal_mammary_gland1.39264061
56MP0004510_myositis1.36599831
57MP0002998_abnormal_bone_remodeling1.33679382
58MP0004782_abnormal_surfactant_physiolog1.33669623
59MP0004272_abnormal_basement_membrane1.33160782
60MP0003690_abnormal_glial_cell1.33067788
61MP0000778_abnormal_nervous_system1.33010435
62MP0004859_abnormal_synaptic_plasticity1.31891732
63MP0001849_ear_inflammation1.31010644
64MP0003634_abnormal_glial_cell1.30147058
65MP0002138_abnormal_hepatobiliary_system1.29977097
66MP0002060_abnormal_skin_morphology1.29087693
67MP0002452_abnormal_antigen_presenting1.25639095
68MP0000383_abnormal_hair_follicle1.22765786
69MP0003656_abnormal_erythrocyte_physiolo1.22622992
70MP0001790_abnormal_immune_system1.22452211
71MP0005387_immune_system_phenotype1.22452211
72MP0001845_abnormal_inflammatory_respons1.20693082
73MP0002295_abnormal_pulmonary_circulatio1.17265177
74MP0002877_abnormal_melanocyte_morpholog1.16609615
75MP0010030_abnormal_orbit_morphology1.16177846
76MP0005397_hematopoietic_system_phenotyp1.15052620
77MP0001545_abnormal_hematopoietic_system1.15052620
78MP0005164_abnormal_response_to1.14660561
79MP0002971_abnormal_brown_adipose1.12710335
80MP0003122_maternal_imprinting1.12110339
81MP0005257_abnormal_intraocular_pressure1.11468932
82MP0002405_respiratory_system_inflammati1.10690831
83MP0005595_abnormal_vascular_smooth1.09737627
84MP0004043_abnormal_pH_regulation1.08917680
85MP0001299_abnormal_eye_distance/1.07899057
86MP0003091_abnormal_cell_migration1.07609895
87MP0001216_abnormal_epidermal_layer1.07410808
88MP0002723_abnormal_immune_serum1.07036392
89MP0005167_abnormal_blood-brain_barrier1.06611507
90MP0001756_abnormal_urination1.05956514
91MP0010771_integument_phenotype1.05574447
92MP0000377_abnormal_hair_follicle1.04195190
93MP0002006_tumorigenesis1.02766504
94MP0005390_skeleton_phenotype1.02658343
95MP0005174_abnormal_tail_pigmentation1.02515738
96MP0000762_abnormal_tongue_morphology1.02188810
97MP0005365_abnormal_bile_salt1.01221228
98MP0005084_abnormal_gallbladder_morpholo1.01020877
99MP0001958_emphysema1.00773811
100MP0005503_abnormal_tendon_morphology1.00514774
101MP0005464_abnormal_platelet_physiology1.00174610
102MP0001348_abnormal_lacrimal_gland0.99997591
103MP0005058_abnormal_lysosome_morphology0.99254710
104MP0003252_abnormal_bile_duct0.98950562
105MP0004883_abnormal_blood_vessel0.98084754
106MP0001800_abnormal_humoral_immune0.96835567
107MP0001853_heart_inflammation0.95873581
108MP0005248_abnormal_Harderian_gland0.95144581
109MP0003186_abnormal_redox_activity0.94553356
110MP0001819_abnormal_immune_cell0.93041178
111MP0005367_renal/urinary_system_phenotyp0.92083071
112MP0000516_abnormal_urinary_system0.92083071
113MP0002735_abnormal_chemical_nociception0.91803032
114MP0009053_abnormal_anal_canal0.91586442
115MP0005166_decreased_susceptibility_to0.90789061
116MP0000569_abnormal_digit_pigmentation0.90761855
117MP0002277_abnormal_respiratory_mucosa0.90700185
118MP0003075_altered_response_to0.90599056
119MP0002420_abnormal_adaptive_immunity0.89092335
120MP0008469_abnormal_protein_level0.88104006
121MP0004019_abnormal_vitamin_homeostasis0.87089285
122MP0008004_abnormal_stomach_pH0.84764294
123MP0000627_abnormal_mammary_gland0.84500285
124MP0003828_pulmonary_edema0.83191632
125MP0002098_abnormal_vibrissa_morphology0.82943681
126MP0001915_intracranial_hemorrhage0.81858267
127MP0000490_abnormal_crypts_of0.80049500
128MP0002136_abnormal_kidney_physiology0.78659343
129MP0001984_abnormal_olfaction0.78496208
130MP0010329_abnormal_lipoprotein_level0.77827011
131MP0010368_abnormal_lymphatic_system0.77481079
132MP0001879_abnormal_lymphatic_vessel0.75647291
133MP0005501_abnormal_skin_physiology0.75615183
134MP0005671_abnormal_response_to0.75173274
135MP0000767_abnormal_smooth_muscle0.75060175
136MP0004484_altered_response_of0.74920523
137MP0001243_abnormal_dermal_layer0.74562904
138MP0003795_abnormal_bone_structure0.74533492
139MP0000003_abnormal_adipose_tissue0.73980308
140MP0010678_abnormal_skin_adnexa0.73829536
141MP0005085_abnormal_gallbladder_physiolo0.73731665
142MP0000249_abnormal_blood_vessel0.73167232
143MP0000477_abnormal_intestine_morphology0.72787165
144MP0009763_increased_sensitivity_to0.72590281
145MP0000609_abnormal_liver_physiology0.72520169
146MP0010307_abnormal_tumor_latency0.72293171
147MP0000955_abnormal_spinal_cord0.67012269
148MP0000462_abnormal_digestive_system0.65427479
149MP0005360_urolithiasis0.65412753
150MP0002734_abnormal_mechanical_nocicepti0.65065860
151MP0000920_abnormal_myelination0.64126700
152MP0001944_abnormal_pancreas_morphology0.63107133
153MP0004381_abnormal_hair_follicle0.62972501
154MP0005375_adipose_tissue_phenotype0.62162806
155MP0003632_abnormal_nervous_system0.60061618
156MP0005535_abnormal_body_temperature0.59262559
157MP0000467_abnormal_esophagus_morphology0.58278716
158MP0000747_muscle_weakness0.57962779
159MP0000015_abnormal_ear_pigmentation0.55854825

Predicted human phenotypes

RankGene SetZ-score
1Nuclear cataract (HP:0100018)4.31389259
2Eczematoid dermatitis (HP:0000976)4.22596219
3Neurofibrillary tangles (HP:0002185)4.18175912
4Abnormality of nail color (HP:0100643)3.94195592
5Orchitis (HP:0100796)3.81695897
6Abnormality of liposaccharide metabolism (HP:0010968)3.66575681
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.66575681
8Abnormality of glycolipid metabolism (HP:0010969)3.66575681
9Interstitial pulmonary disease (HP:0006530)3.28829195
10Myositis (HP:0100614)3.26222436
11Recurrent gram-negative bacterial infections (HP:0005420)3.23385334
12Retrobulbar optic neuritis (HP:0100654)3.18806313
13Optic neuritis (HP:0100653)3.18806313
14Spondylolisthesis (HP:0003302)3.02966154
15Vacuolated lymphocytes (HP:0001922)3.01852428
16Palmoplantar hyperkeratosis (HP:0000972)3.00354978
17Recurrent bacterial skin infections (HP:0005406)2.99890070
18Protrusio acetabuli (HP:0003179)2.94985399
19Systemic lupus erythematosus (HP:0002725)2.91825847
20Esophageal varix (HP:0002040)2.91144352
21Action tremor (HP:0002345)2.83452340
22Palmar hyperkeratosis (HP:0010765)2.82483242
23Right ventricular cardiomyopathy (HP:0011663)2.79949583
24Increased CSF protein (HP:0002922)2.78372547
25Recurrent abscess formation (HP:0002722)2.77044498
26Vertebral arch anomaly (HP:0008438)2.71300826
27Atrophic scars (HP:0001075)2.70483182
28Persistence of primary teeth (HP:0006335)2.69738990
29Cerebral inclusion bodies (HP:0100314)2.69415084
30Abnormality of macrophages (HP:0004311)2.68193639
31Aortic dissection (HP:0002647)2.67741382
32Follicular hyperkeratosis (HP:0007502)2.67502153
33Autoimmune thrombocytopenia (HP:0001973)2.65703960
34Loss of speech (HP:0002371)2.65133923
35Rectal prolapse (HP:0002035)2.62194399
36Papillary thyroid carcinoma (HP:0002895)2.61808287
37Zonular cataract (HP:0010920)2.58571846
38Periodontitis (HP:0000704)2.57603093
39Genu recurvatum (HP:0002816)2.54173242
40Arterial tortuosity (HP:0005116)2.52044814
41Tetraparesis (HP:0002273)2.48612095
42Aortic aneurysm (HP:0004942)2.47520975
43Micronodular cirrhosis (HP:0001413)2.45049070
44Dysostosis multiplex (HP:0000943)2.42579678
45Neonatal short-limb short stature (HP:0008921)2.41885287
46Elevated erythrocyte sedimentation rate (HP:0003565)2.41379275
47Thick nail (HP:0001805)2.40663050
48Vertebral compression fractures (HP:0002953)2.38858964
49Abnormality of proline metabolism (HP:0010907)2.37586310
50Hydroxyprolinuria (HP:0003080)2.37586310
51Onycholysis (HP:0001806)2.36971804
52Postural tremor (HP:0002174)2.36230615
53Milia (HP:0001056)2.35869560
54Gingivitis (HP:0000230)2.35387166
55Cerebral hemorrhage (HP:0001342)2.34187911
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30751861
57Abnormality of polysaccharide metabolism (HP:0011012)2.30751861
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30751861
59Subacute progressive viral hepatitis (HP:0006572)2.30527183
60Premature loss of primary teeth (HP:0006323)2.30338774
61Vascular tortuosity (HP:0004948)2.29457304
62Cubitus valgus (HP:0002967)2.28945647
63Protuberant abdomen (HP:0001538)2.28709799
64Amyloidosis (HP:0011034)2.26349453
65Cardiomegaly (HP:0001640)2.23150534
66Abnormality of dentin (HP:0010299)2.22477681
67Nephritis (HP:0000123)2.21647772
68Curly hair (HP:0002212)2.20722735
69Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.20293347
70Cerebral aneurysm (HP:0004944)2.20236419
71Malnutrition (HP:0004395)2.19008443
72Inappropriate behavior (HP:0000719)2.18849065
73Myocardial infarction (HP:0001658)2.17037986
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.16780259
75Osteolytic defects of the hand bones (HP:0009699)2.16780259
76Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15802534
77Hyperextensible skin (HP:0000974)2.15555128
78Soft skin (HP:0000977)2.15474137
79Keratoconjunctivitis sicca (HP:0001097)2.14686884
80Peritonitis (HP:0002586)2.14242051
81Mediastinal lymphadenopathy (HP:0100721)2.13032463
82Arterial thrombosis (HP:0004420)2.12638474
83Hematochezia (HP:0002573)2.09982920
84Hammertoe (HP:0001765)2.09839265
85Abnormality of the pericardium (HP:0001697)2.04983234
86Keratoconjunctivitis (HP:0001096)2.04785266
87Porencephaly (HP:0002132)2.04662642
88Congenital sensorineural hearing impairment (HP:0008527)2.03680546
89Tibial bowing (HP:0002982)2.03141207
90Hemorrhage of the eye (HP:0011885)2.01843944
91Increased cerebral lipofuscin (HP:0011813)2.01648002
92Breech presentation (HP:0001623)1.99921909
93Mitral stenosis (HP:0001718)1.98025431
94Bladder diverticulum (HP:0000015)1.97561138
95Cervical subluxation (HP:0003308)1.97009540
96Femoral bowing (HP:0002980)1.96279152
97Alopecia of scalp (HP:0002293)1.95357971
98Wormian bones (HP:0002645)1.94501449
99Mutism (HP:0002300)1.94494643
100Termporal pattern (HP:0011008)1.94456994
101Insidious onset (HP:0003587)1.94456994
102Morphological abnormality of the middle ear (HP:0008609)1.93015312
103Increased density of long bones (HP:0006392)1.92242134
104Plantar hyperkeratosis (HP:0007556)1.92240303
105Gastrointestinal carcinoma (HP:0002672)1.90649351
106Malignant gastrointestinal tract tumors (HP:0006749)1.90649351
107Apathy (HP:0000741)1.89605936
108Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89326598
109Amelogenesis imperfecta (HP:0000705)1.89158429
110Polyphagia (HP:0002591)1.88466495
111Hypoplasia of the iris (HP:0007676)1.87882335
112Proximal tubulopathy (HP:0000114)1.87486374
113Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.86246437
114Unilateral renal agenesis (HP:0000122)1.86220715
115Abnormality of the nasal mucosa (HP:0000433)1.84536140
116Mitral valve prolapse (HP:0001634)1.84353280
117Increased neuronal autofluorescent lipopigment (HP:0002074)1.83941545
118Glomerulonephritis (HP:0000099)1.83796979
119Stenosis of the external auditory canal (HP:0000402)1.82844153
120Fused cervical vertebrae (HP:0002949)1.81656955
121Pustule (HP:0200039)1.81578459
122Axonal loss (HP:0003447)1.80996618
123Wide anterior fontanel (HP:0000260)1.80038189
124Fragile nails (HP:0001808)1.79501380
125Fragile skin (HP:0001030)1.79395693
126Cheilitis (HP:0100825)1.78845917
127Camptodactyly of toe (HP:0001836)1.78323117
128Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.77598457
129Recurrent fungal infections (HP:0002841)1.77295295
130Diminished motivation (HP:0000745)1.76342941
131Agnosia (HP:0010524)1.76153740
132Aneurysm (HP:0002617)1.75815086
133Asymmetric septal hypertrophy (HP:0001670)1.75674997
134Germ cell neoplasia (HP:0100728)1.75277879
135Radial bowing (HP:0002986)1.75235471
136Premature rupture of membranes (HP:0001788)1.74494244
137Disinhibition (HP:0000734)1.74273968
138Thrombocytosis (HP:0001894)1.74231575
139Nasal polyposis (HP:0100582)1.72367374
140Nausea (HP:0002018)1.71678859
141Pheochromocytoma (HP:0002666)1.71012960
142Urticaria (HP:0001025)1.70881527
143Large eyes (HP:0001090)1.70616728
144Exocrine pancreatic insufficiency (HP:0001738)1.69400953
145Corneal dystrophy (HP:0001131)1.69293565
146Abnormality of the nasal septum (HP:0000419)1.67792217
147Hoarse voice (HP:0001609)1.67601243
148Thyroid carcinoma (HP:0002890)1.67492907
149Abnormality of monocarboxylic acid metabolism (HP:0010996)1.67046221
150Ulnar claw (HP:0001178)1.66555708
151Vasculitis (HP:0002633)1.66460041
152Adactyly (HP:0009776)1.66048622
153Bone pain (HP:0002653)1.65261672
154Gingival bleeding (HP:0000225)1.64585352
155Bicuspid aortic valve (HP:0001647)1.63976659
156Buphthalmos (HP:0000557)1.63677946
157Neonatal death (HP:0003811)1.63500022
158Abnormal hemoglobin (HP:0011902)1.63485437
159Abnormality of the ischium (HP:0003174)1.63190839
160Hyperkalemia (HP:0002153)1.62917779
161Spastic diplegia (HP:0001264)1.62908441
162Urinary glycosaminoglycan excretion (HP:0003541)1.62531567
163Mucopolysacchariduria (HP:0008155)1.62531567
164Fetal akinesia sequence (HP:0001989)1.62136388
165Increased IgE level (HP:0003212)1.62091827
166Woolly hair (HP:0002224)1.59382438
167Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.58811967
168Atrioventricular canal defect (HP:0006695)1.58089674
169Abnormality of complement system (HP:0005339)1.57730146
170Gastrointestinal infarctions (HP:0005244)1.57547109
171Thickened calvaria (HP:0002684)1.57239264
172Bundle branch block (HP:0011710)1.57103789
173Agitation (HP:0000713)1.54675066
174Widely spaced teeth (HP:0000687)1.53083502
175Mitral regurgitation (HP:0001653)1.52870365
176Delayed gross motor development (HP:0002194)1.52851433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.49324184
2ERN13.28250283
3MAP3K143.26321991
4MAP3K92.58515331
5NTRK12.54552976
6KSR12.52331702
7TBK12.51420021
8IRAK32.48764507
9STK242.46430204
10EPHA22.39857601
11CASK2.34258623
12FGFR32.31158069
13MOS2.29883214
14MST1R2.02986830
15EPHB22.01971940
16KSR22.01810513
17BMX2.01679452
18MAP4K21.91965826
19MAPKAPK31.90097899
20RIPK11.87558986
21EPHA31.86958304
22TGFBR21.85455688
23PKN21.82579080
24DDR21.79859365
25EPHB11.78863130
26JAK31.78785609
27TAOK31.77778646
28BCR1.77292237
29TYK21.75700580
30CDK121.66988308
31PTK61.64202203
32IKBKB1.62130724
33MARK11.61172082
34MST41.58197404
35CHUK1.54848094
36IKBKE1.53416661
37BRD41.51896533
38SIK11.46868889
39TRIB31.45992187
40PAK41.45830148
41RPS6KB21.44683401
42NEK91.43225642
43FGFR41.41955827
44JAK11.40484725
45RPS6KA41.36828458
46PBK1.36524075
47AKT31.32117397
48MATK1.29201614
49YES11.27856011
50EEF2K1.26014539
51LATS11.24747657
52SIK21.24708145
53TRPM71.24486680
54PIM11.24222404
55PASK1.22477536
56MAP3K61.18028343
57MAP3K31.17212767
58MET1.16791476
59TESK11.16351539
60MAP3K41.16326913
61MAPK151.16147404
62SCYL21.15350874
63TGFBR11.13082000
64NTRK31.11441651
65ERBB31.09940203
66CSK1.02656772
67STK31.02551088
68ARAF1.02070096
69LRRK21.01286056
70PTK21.00855094
71MAP3K100.99429975
72CDK60.99338097
73MAP2K20.98598599
74MAP3K130.94667074
75TAOK10.91789913
76STK100.91312158
77GRK70.91268933
78RET0.89632753
79FER0.89482437
80STK38L0.89392219
81MAP3K20.88458548
82FGFR10.88085164
83ROCK20.84944770
84FLT30.83692834
85PINK10.83380921
86MAP3K10.82699199
87NUAK10.82595356
88RIPK40.79706195
89PHKG10.79289925
90PHKG20.79289925
91TTN0.78925492
92PDGFRA0.78802364
93MARK30.78341758
94JAK20.77046045
95MYLK0.74305987
96CSNK1G20.72896501
97ERBB40.71584226
98CAMK1G0.71235826
99IRAK20.71195241
100RPS6KA10.70233047
101GSK3A0.69919587
102PIM20.69673139
103BTK0.68806503
104NTRK20.67151483
105ABL20.65705160
106DYRK1B0.65363608
107MAPK70.63836597
108MAP3K50.62655263
109PRKG20.61457441
110DYRK30.60604883
111MAPKAPK20.59086551
112TXK0.58213067
113IRAK40.58014072
114WNK10.57951024
115CDK50.57212130
116MAP3K80.56461458
117SGK20.55820199
118PRKCE0.55805154
119NLK0.55390998
120DMPK0.54752736
121IRAK10.53551452
122RPS6KB10.53028165
123HCK0.52582294
124NME20.52352904
125ADRBK20.52262342
126SGK30.51629539
127ABL10.51324642
128STK40.49583143
129EGFR0.49556795
130ERBB20.48340556
131PIK3CA0.48273444
132PAK60.48254683
133BMPR20.48048116
134BCKDK0.47515981
135FRK0.47236022
136MTOR0.47056951
137CAMK2D0.46122433
138PDGFRB0.45944215
139MAP2K40.44988966
140KIT0.44834486
141MAPK100.44239683
142KDR0.43071139
143LATS20.43063221
144WNK40.42971331
145CSF1R0.42729915
146SIK30.42472235
147RPS6KA20.42416211
148RAF10.42398572
149DAPK20.42396994
150ACVR1B0.42363464
151PAK30.42108057
152EIF2AK20.41072948
153PIK3CG0.40995115
154BLK0.40807329
155MAP2K30.40425943
156PAK20.39905152
157INSR0.39280466
158SGK2230.38655490
159SGK4940.38655490
160ZAP700.38176044
161ROCK10.37655712
162MAP2K60.37211237

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.71069219
2Legionellosis_Homo sapiens_hsa051342.49079991
3TNF signaling pathway_Homo sapiens_hsa046682.24227375
4Staphylococcus aureus infection_Homo sapiens_hsa051502.18208735
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.16738381
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.14977588
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09603428
8Osteoclast differentiation_Homo sapiens_hsa043802.08452125
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99623806
10Malaria_Homo sapiens_hsa051441.91853970
11Rheumatoid arthritis_Homo sapiens_hsa053231.75891206
12Graft-versus-host disease_Homo sapiens_hsa053321.75623003
13Toxoplasmosis_Homo sapiens_hsa051451.75068656
14Pertussis_Homo sapiens_hsa051331.73709261
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71071439
16Amoebiasis_Homo sapiens_hsa051461.61393477
17Tuberculosis_Homo sapiens_hsa051521.61216185
18Sphingolipid metabolism_Homo sapiens_hsa006001.57031679
19Influenza A_Homo sapiens_hsa051641.56008252
20Apoptosis_Homo sapiens_hsa042101.51690645
21Protein digestion and absorption_Homo sapiens_hsa049741.48652305
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46151299
23Complement and coagulation cascades_Homo sapiens_hsa046101.44956378
24Long-term depression_Homo sapiens_hsa047301.42283850
25Caffeine metabolism_Homo sapiens_hsa002321.40636277
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40510376
27Salmonella infection_Homo sapiens_hsa051321.35034914
28Renal cell carcinoma_Homo sapiens_hsa052111.35006468
29Antigen processing and presentation_Homo sapiens_hsa046121.34887232
30Measles_Homo sapiens_hsa051621.34778180
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33162477
32African trypanosomiasis_Homo sapiens_hsa051431.29301093
33Other glycan degradation_Homo sapiens_hsa005111.29238181
34Small cell lung cancer_Homo sapiens_hsa052221.28735880
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28590319
36Herpes simplex infection_Homo sapiens_hsa051681.27652178
37Sulfur metabolism_Homo sapiens_hsa009201.25253270
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23420721
39Lysosome_Homo sapiens_hsa041421.20434717
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20422125
41Adherens junction_Homo sapiens_hsa045201.19854269
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.19013560
43ECM-receptor interaction_Homo sapiens_hsa045121.16418113
44Type II diabetes mellitus_Homo sapiens_hsa049301.16411283
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.15702992
46Circadian rhythm_Homo sapiens_hsa047101.13600450
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.13146179
48Renin secretion_Homo sapiens_hsa049241.11529124
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08109013
50Notch signaling pathway_Homo sapiens_hsa043301.07609755
51Prion diseases_Homo sapiens_hsa050201.06857826
52Hepatitis B_Homo sapiens_hsa051611.05959703
53Phagosome_Homo sapiens_hsa041451.04689768
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04383260
55Proteoglycans in cancer_Homo sapiens_hsa052051.02594543
56Bladder cancer_Homo sapiens_hsa052191.01590666
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01341056
58Hematopoietic cell lineage_Homo sapiens_hsa046401.00093197
59Circadian entrainment_Homo sapiens_hsa047131.00091365
60Hepatitis C_Homo sapiens_hsa051601.00000846
61Chronic myeloid leukemia_Homo sapiens_hsa052200.95833766
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.93722642
63Shigellosis_Homo sapiens_hsa051310.93694699
64MicroRNAs in cancer_Homo sapiens_hsa052060.92160780
65GnRH signaling pathway_Homo sapiens_hsa049120.91030002
66Focal adhesion_Homo sapiens_hsa045100.90294884
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.88869708
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88850177
69ErbB signaling pathway_Homo sapiens_hsa040120.88491878
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88165935
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87520723
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87284141
73Viral myocarditis_Homo sapiens_hsa054160.86200482
74Chemical carcinogenesis_Homo sapiens_hsa052040.84068492
75Acute myeloid leukemia_Homo sapiens_hsa052210.83133335
76Prolactin signaling pathway_Homo sapiens_hsa049170.82268525
77Long-term potentiation_Homo sapiens_hsa047200.82168971
78Glutathione metabolism_Homo sapiens_hsa004800.81492458
79Insulin resistance_Homo sapiens_hsa049310.81368831
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81213079
81p53 signaling pathway_Homo sapiens_hsa041150.80070647
82Allograft rejection_Homo sapiens_hsa053300.79839870
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79128347
84Fat digestion and absorption_Homo sapiens_hsa049750.77622659
85TGF-beta signaling pathway_Homo sapiens_hsa043500.77066361
86Gap junction_Homo sapiens_hsa045400.76435094
87Dopaminergic synapse_Homo sapiens_hsa047280.76180030
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.75330879
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74042834
90Insulin secretion_Homo sapiens_hsa049110.73651590
91Pancreatic cancer_Homo sapiens_hsa052120.72935466
92Insulin signaling pathway_Homo sapiens_hsa049100.72280758
93Fructose and mannose metabolism_Homo sapiens_hsa000510.71733898
94Collecting duct acid secretion_Homo sapiens_hsa049660.71574010
95Glutamatergic synapse_Homo sapiens_hsa047240.70945348
96Hippo signaling pathway_Homo sapiens_hsa043900.70586722
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.70443401
98Bile secretion_Homo sapiens_hsa049760.69229622
99Vibrio cholerae infection_Homo sapiens_hsa051100.67837552
100Cocaine addiction_Homo sapiens_hsa050300.67347876
101Tight junction_Homo sapiens_hsa045300.67163559
102Serotonergic synapse_Homo sapiens_hsa047260.67109368
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66976814
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66669619
105Axon guidance_Homo sapiens_hsa043600.66228461
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66121045
107Ether lipid metabolism_Homo sapiens_hsa005650.64352909
108Histidine metabolism_Homo sapiens_hsa003400.62625817
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62458714
110Pancreatic secretion_Homo sapiens_hsa049720.62292820
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62152200
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62078099
113Endometrial cancer_Homo sapiens_hsa052130.60672213
114Chemokine signaling pathway_Homo sapiens_hsa040620.60272756
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59519063
116Dorso-ventral axis formation_Homo sapiens_hsa043200.59474335
117Galactose metabolism_Homo sapiens_hsa000520.59394271
118Asthma_Homo sapiens_hsa053100.58879192
119HTLV-I infection_Homo sapiens_hsa051660.57871703
120HIF-1 signaling pathway_Homo sapiens_hsa040660.57812996
121Cholinergic synapse_Homo sapiens_hsa047250.57657656
122Estrogen signaling pathway_Homo sapiens_hsa049150.57235978
123Renin-angiotensin system_Homo sapiens_hsa046140.57126822
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.55433803
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55167822
126FoxO signaling pathway_Homo sapiens_hsa040680.54614980
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54254902
128Salivary secretion_Homo sapiens_hsa049700.54071581
129Inositol phosphate metabolism_Homo sapiens_hsa005620.53956445
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53803548
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.53459584
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.53162053
133Type I diabetes mellitus_Homo sapiens_hsa049400.52856367
134VEGF signaling pathway_Homo sapiens_hsa043700.52313931
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.50576341
136Selenocompound metabolism_Homo sapiens_hsa004500.50279595
137Oxytocin signaling pathway_Homo sapiens_hsa049210.50144027
138Mineral absorption_Homo sapiens_hsa049780.49998748
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49919992
140Starch and sucrose metabolism_Homo sapiens_hsa005000.49404104
141Pathways in cancer_Homo sapiens_hsa052000.49399989
142Dilated cardiomyopathy_Homo sapiens_hsa054140.49273115
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49055074
144Platelet activation_Homo sapiens_hsa046110.49011272
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48720100
146Melanogenesis_Homo sapiens_hsa049160.48485795
147cAMP signaling pathway_Homo sapiens_hsa040240.48255560
148B cell receptor signaling pathway_Homo sapiens_hsa046620.48154547
149AMPK signaling pathway_Homo sapiens_hsa041520.46377902
150Viral carcinogenesis_Homo sapiens_hsa052030.46170350
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45867279
152PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45794718
153Retinol metabolism_Homo sapiens_hsa008300.45720179
154Nitrogen metabolism_Homo sapiens_hsa009100.45546526
155mTOR signaling pathway_Homo sapiens_hsa041500.45538406
156Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42781146
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40373998
158Prostate cancer_Homo sapiens_hsa052150.40161134
159PPAR signaling pathway_Homo sapiens_hsa033200.39596846
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39507114

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