ARRDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.60703367
2L-phenylalanine catabolic process (GO:0006559)6.60703367
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.34967141
4L-phenylalanine metabolic process (GO:0006558)6.34967141
5positive regulation of gamma-delta T cell activation (GO:0046645)5.53775934
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.45863900
7negative regulation of cell killing (GO:0031342)5.45863900
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.92205070
9aromatic amino acid family catabolic process (GO:0009074)4.91510346
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.74928611
11antigen processing and presentation of endogenous antigen (GO:0019883)4.71714152
12negative regulation of erythrocyte differentiation (GO:0045647)4.70556578
13cysteine metabolic process (GO:0006534)4.70403399
14fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.57265217
15alpha-linolenic acid metabolic process (GO:0036109)4.55302735
16positive thymic T cell selection (GO:0045059)4.52834459
17sulfur amino acid catabolic process (GO:0000098)4.51385470
18regulation of gamma-delta T cell activation (GO:0046643)4.39127741
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.36166229
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.35821577
21regulation of gamma-delta T cell differentiation (GO:0045586)4.30761408
22creatine metabolic process (GO:0006600)4.27359376
23bile acid biosynthetic process (GO:0006699)4.24505974
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.13207963
25kynurenine metabolic process (GO:0070189)4.04597677
26protoporphyrinogen IX metabolic process (GO:0046501)3.99358642
27positive T cell selection (GO:0043368)3.91890503
28regulation of B cell receptor signaling pathway (GO:0050855)3.91774476
29heme transport (GO:0015886)3.88444779
30detection of other organism (GO:0098543)3.86498001
31response to muramyl dipeptide (GO:0032495)3.84925618
32detection of bacterium (GO:0016045)3.84919870
33neutrophil activation involved in immune response (GO:0002283)3.84292128
34negative thymic T cell selection (GO:0045060)3.81091193
35indole-containing compound catabolic process (GO:0042436)3.79912308
36indolalkylamine catabolic process (GO:0046218)3.79912308
37tryptophan catabolic process (GO:0006569)3.79912308
38bile acid metabolic process (GO:0008206)3.78606117
39lysine metabolic process (GO:0006553)3.77704904
40lysine catabolic process (GO:0006554)3.77704904
41response to peptidoglycan (GO:0032494)3.76977350
42tolerance induction (GO:0002507)3.75559577
43thymic T cell selection (GO:0045061)3.74139136
44negative T cell selection (GO:0043383)3.72964088
45glyoxylate metabolic process (GO:0046487)3.70114032
46leukocyte aggregation (GO:0070486)3.68639386
47positive regulation by symbiont of host defense response (GO:0052509)3.68539909
48modulation by symbiont of host defense response (GO:0052031)3.68539909
49modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.68539909
50modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.68539909
51positive regulation by organism of defense response of other organism involved in symbiotic interact3.68539909
52modulation by symbiont of host immune response (GO:0052553)3.68539909
53T cell selection (GO:0045058)3.65963825
54germinal center formation (GO:0002467)3.65595547
55heme biosynthetic process (GO:0006783)3.60713632
56NIK/NF-kappaB signaling (GO:0038061)3.58589382
57negative regulation of interleukin-12 production (GO:0032695)3.57787263
58complement activation, alternative pathway (GO:0006957)3.57496355
59urea metabolic process (GO:0019627)3.55777849
60urea cycle (GO:0000050)3.55777849
61tryptophan metabolic process (GO:0006568)3.50883536
62serine family amino acid catabolic process (GO:0009071)3.47851174
63serine family amino acid metabolic process (GO:0009069)3.46823027
64plasma lipoprotein particle clearance (GO:0034381)3.46164062
65porphyrin-containing compound biosynthetic process (GO:0006779)3.45721191
66protoporphyrinogen IX biosynthetic process (GO:0006782)3.45636018
67macrophage activation involved in immune response (GO:0002281)3.43802165
68aromatic amino acid family metabolic process (GO:0009072)3.43616448
69acetyl-CoA metabolic process (GO:0006084)3.42162634
70response to mercury ion (GO:0046689)3.41942272
71regulation of triglyceride catabolic process (GO:0010896)3.41594119
72negative regulation of lymphocyte mediated immunity (GO:0002707)3.40577833
73glycine metabolic process (GO:0006544)3.40192064
74coenzyme catabolic process (GO:0009109)3.40186216
75cofactor catabolic process (GO:0051187)3.39934298
76central nervous system myelination (GO:0022010)3.39628481
77axon ensheathment in central nervous system (GO:0032291)3.39628481
78regulation of cholesterol homeostasis (GO:2000188)3.39586817
79immunoglobulin mediated immune response (GO:0016064)3.39335502
80heme metabolic process (GO:0042168)3.38643318
81aspartate family amino acid catabolic process (GO:0009068)3.36466989
82regulation of protein activation cascade (GO:2000257)3.36227561
83high-density lipoprotein particle remodeling (GO:0034375)3.36028406
84nitrogen cycle metabolic process (GO:0071941)3.35964258
85short-chain fatty acid metabolic process (GO:0046459)3.35067045
86positive regulation of B cell differentiation (GO:0045579)3.33880501
87valine metabolic process (GO:0006573)3.31627581
88fatty acid catabolic process (GO:0009062)3.31085552
89response to interleukin-15 (GO:0070672)3.29770242
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.29530041
912-oxoglutarate metabolic process (GO:0006103)3.28992774
92porphyrin-containing compound metabolic process (GO:0006778)3.28554623
93alpha-amino acid catabolic process (GO:1901606)3.28529611
94B cell receptor signaling pathway (GO:0050853)3.27855762
95positive regulation of granulocyte differentiation (GO:0030854)3.25512712
96amino-acid betaine metabolic process (GO:0006577)3.24609267
97negative regulation of leukocyte mediated immunity (GO:0002704)3.24427500
98negative regulation of sterol transport (GO:0032372)3.23932586
99negative regulation of cholesterol transport (GO:0032375)3.23932586
100protein-lipid complex assembly (GO:0065005)3.22463653
101protein carboxylation (GO:0018214)3.20915218
102peptidyl-glutamic acid carboxylation (GO:0017187)3.20915218
103negative regulation of T cell mediated immunity (GO:0002710)3.19330205
104fatty acid beta-oxidation (GO:0006635)3.19271115
105cellular amino acid catabolic process (GO:0009063)3.18797397
106negative regulation of fibrinolysis (GO:0051918)3.17255373
107fatty acid transmembrane transport (GO:1902001)3.15723761
108serine family amino acid biosynthetic process (GO:0009070)3.15721908
109regulation of complement activation (GO:0030449)3.15575434
110negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.14791295
111tetrapyrrole biosynthetic process (GO:0033014)3.14034610
112glutamate metabolic process (GO:0006536)3.13536679
113regulation of mast cell degranulation (GO:0043304)3.12671491
114cellular extravasation (GO:0045123)3.12520024
115regulation of T cell tolerance induction (GO:0002664)3.12051018
116monocarboxylic acid catabolic process (GO:0072329)3.09685172
117regulation of cholesterol metabolic process (GO:0090181)3.08125135
118response to methylmercury (GO:0051597)3.07876527
119ethanol oxidation (GO:0006069)3.06922723
120fatty acid oxidation (GO:0019395)3.06918126
121triglyceride homeostasis (GO:0070328)3.05365951
122acylglycerol homeostasis (GO:0055090)3.05365951
123positive regulation of lipoprotein lipase activity (GO:0051006)3.03600997
124positive regulation of triglyceride lipase activity (GO:0061365)3.03600997
125carboxylic acid catabolic process (GO:0046395)3.03365461
126organic acid catabolic process (GO:0016054)3.03365461
127mannose metabolic process (GO:0006013)3.02158860
128detection of external biotic stimulus (GO:0098581)3.02149822
129very long-chain fatty acid metabolic process (GO:0000038)3.01110436
130regulation of cholesterol esterification (GO:0010872)3.00801003
131plasma lipoprotein particle assembly (GO:0034377)3.00791608
132carnitine shuttle (GO:0006853)2.99976425
133negative regulation of innate immune response (GO:0045824)2.99641174
134regulation of B cell differentiation (GO:0045577)2.99627215
135lipid oxidation (GO:0034440)2.99379699
136fatty acid elongation (GO:0030497)2.97514444
137T cell migration (GO:0072678)2.97396126
138regulation of tolerance induction (GO:0002643)2.97134161
139positive regulation of Rap GTPase activity (GO:0032854)2.94481985
140membrane tubulation (GO:0097320)2.94449320
141regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94347216
142regulation of fibrinolysis (GO:0051917)2.94212427
143regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93003105
144biotin metabolic process (GO:0006768)2.92996307
145protein-lipid complex remodeling (GO:0034368)2.92496097
146macromolecular complex remodeling (GO:0034367)2.92496097
147plasma lipoprotein particle remodeling (GO:0034369)2.92496097
148positive regulation of triglyceride metabolic process (GO:0090208)2.90639875
149tyrosine metabolic process (GO:0006570)2.90587427
150cellular ketone body metabolic process (GO:0046950)2.89799347
151regulation of leukocyte degranulation (GO:0043300)2.89381942
152cholesterol efflux (GO:0033344)2.88759374
153L-serine metabolic process (GO:0006563)2.87690723
154cellular modified amino acid catabolic process (GO:0042219)2.87565097
155negative regulation of cytokine production involved in immune response (GO:0002719)2.87554073
156neutrophil activation (GO:0042119)2.86491162
157type I interferon signaling pathway (GO:0060337)2.86346669
158cellular response to type I interferon (GO:0071357)2.86346669
159response to type I interferon (GO:0034340)2.86049966
160cholesterol homeostasis (GO:0042632)2.83838460
161phospholipid efflux (GO:0033700)2.83780703
162amine catabolic process (GO:0009310)2.82968805
163cellular biogenic amine catabolic process (GO:0042402)2.82968805
164myeloid cell activation involved in immune response (GO:0002275)2.82075227
165regulation of granulocyte differentiation (GO:0030852)2.82061897
166regulation of alpha-beta T cell proliferation (GO:0046640)2.81657879
167negative regulation of T-helper cell differentiation (GO:0045623)2.81355381
168negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.81355381
169regulation of mast cell activation involved in immune response (GO:0033006)2.80148431
170regulation of interferon-beta biosynthetic process (GO:0045357)2.79002135
171positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77600001
172interferon-gamma-mediated signaling pathway (GO:0060333)2.77581573
173negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.77258276
174granulocyte activation (GO:0036230)2.76043318
175cellular response to interleukin-15 (GO:0071350)2.75565758
176regulation of T-helper 2 cell differentiation (GO:0045628)2.71545217
177defense response to protozoan (GO:0042832)2.69174557
178negative regulation of glycoprotein biosynthetic process (GO:0010561)2.68597551
179activated T cell proliferation (GO:0050798)2.66846116
180regulation of natural killer cell mediated immunity (GO:0002715)2.65509154
181regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.65509154
182respiratory burst (GO:0045730)2.63822446
183positive regulation of tolerance induction (GO:0002645)2.61874385
184detection of biotic stimulus (GO:0009595)2.61261715
185regulation of antigen processing and presentation (GO:0002577)2.60847082
186macrophage activation (GO:0042116)2.58535200
187lipopolysaccharide-mediated signaling pathway (GO:0031663)2.58464863
188regulation of interleukin-2 biosynthetic process (GO:0045076)2.57877708
189antigen receptor-mediated signaling pathway (GO:0050851)2.57439869
190negative regulation of interleukin-6 production (GO:0032715)2.56803962
191regulation of T cell mediated cytotoxicity (GO:0001914)2.55913109
192B cell homeostasis (GO:0001782)2.55519553
193response to host immune response (GO:0052572)2.55317101
194response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55317101
195Arp2/3 complex-mediated actin nucleation (GO:0034314)2.54498464
196lymphocyte homeostasis (GO:0002260)2.53874406
197positive regulation of antigen processing and presentation (GO:0002579)2.53181021
198negative regulation of type 2 immune response (GO:0002829)2.52469039
199regulation of necroptotic process (GO:0060544)2.51821470
200antigen processing and presentation via MHC class Ib (GO:0002475)2.51564866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.92825239
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.92709918
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.47349664
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.82270891
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.77333935
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.68195651
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.53791636
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.48033338
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.18182679
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.94336464
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.85861660
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.45632538
13RUNX_20019798_ChIP-Seq_JUKART_Human2.40609602
14* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26560002
15ZNF263_19887448_ChIP-Seq_K562_Human2.25491085
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.12497061
17* GATA1_19941826_ChIP-Seq_K562_Human2.10714250
18GATA1_22025678_ChIP-Seq_K562_Human2.10229235
19MYB_26560356_Chip-Seq_TH2_Human2.07594917
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.03491255
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02537943
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.02041014
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00242598
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.95236447
25SPI1_23127762_ChIP-Seq_K562_Human1.94421676
26* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88998857
27* VDR_21846776_ChIP-Seq_THP-1_Human1.87282472
28MYB_26560356_Chip-Seq_TH1_Human1.85178924
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84284464
30* SPI1_23547873_ChIP-Seq_NB4_Human1.82425959
31GATA1_19941827_ChIP-Seq_MEL_Mouse1.79332535
32* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.75106369
33SCL_19346495_ChIP-Seq_HPC-7_Human1.74402836
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74343381
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72850020
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67481633
37GATA1_22383799_ChIP-Seq_G1ME_Mouse1.63929461
38* MYC_22102868_ChIP-Seq_BL_Human1.52750477
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50726426
40* KDM2B_26808549_Chip-Seq_JURKAT_Human1.49204453
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48870320
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45504445
43* TCF7_22412390_ChIP-Seq_EML_Mouse1.44721251
44* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43556532
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40540024
46CLOCK_20551151_ChIP-Seq_293T_Human1.40435618
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38643591
48GATA3_27048872_Chip-Seq_THYMUS_Human1.38447703
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36650156
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36534859
51* ELK3_25401928_ChIP-Seq_HUVEC_Human1.36145601
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36011951
53* ELF1_20517297_ChIP-Seq_JURKAT_Human1.33595379
54LXR_22292898_ChIP-Seq_THP-1_Human1.31642257
55* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31031391
56* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30653308
57* MAF_26560356_Chip-Seq_TH1_Human1.29663252
58KDM2B_26808549_Chip-Seq_DND41_Human1.29528335
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27202544
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26941329
61* STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26883562
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26810628
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.26440976
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25954175
65VDR_24787735_ChIP-Seq_THP-1_Human1.25651781
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25269979
67* BCOR_27268052_Chip-Seq_Bcells_Human1.24374529
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.23676390
69MAF_26560356_Chip-Seq_TH2_Human1.22532846
70* GATA2_19941826_ChIP-Seq_K562_Human1.21673219
71* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21414690
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.20924887
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20890941
74* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19947570
75UTX_26944678_Chip-Seq_JUKART_Human1.19935154
76* P68_20966046_ChIP-Seq_HELA_Human1.19492806
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17597584
78SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17562469
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17496742
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16907098
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16700545
82KDM2B_26808549_Chip-Seq_K562_Human1.16588600
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14324594
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13195207
85VDR_24763502_ChIP-Seq_THP-1_Human1.13118559
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12072047
87STAT1_20625510_ChIP-Seq_HELA_Human1.11637476
88IRF8_27001747_Chip-Seq_BMDM_Mouse1.10503268
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10000925
90PU_27001747_Chip-Seq_BMDM_Mouse1.09526435
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09212310
92RACK7_27058665_Chip-Seq_MCF-7_Human1.09135235
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08071334
94TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06241585
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05291549
96SA1_27219007_Chip-Seq_Bcells_Human1.04620545
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04593034
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04546809
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02856599
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02552987
101* CTCF_26484167_Chip-Seq_Bcells_Mouse1.02049921
102GATA2_21666600_ChIP-Seq_HMVEC_Human1.01650554
103* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.01647934
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01260724
105BCL6_27268052_Chip-Seq_Bcells_Human0.98767844
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95767630
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93646804
108* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93570985
109CREB1_26743006_Chip-Seq_LNCaP_Human0.93253629
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.93142373
111* FOXA2_19822575_ChIP-Seq_HepG2_Human0.93099508
112CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92146965
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92016999
114* NCOR1_26117541_ChIP-Seq_K562_Human0.91727034
115YY1_22570637_ChIP-Seq_MALME-3M_Human0.91459547
116IRF8_21731497_ChIP-ChIP_J774_Mouse0.91310527
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91073147
118PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90906723
119* ESR2_21235772_ChIP-Seq_MCF-7_Human0.90519937
120* E2F1_20622854_ChIP-Seq_HELA_Human0.90515626
121CEBPB_22108803_ChIP-Seq_LS180_Human0.90244438
122SMC4_20622854_ChIP-Seq_HELA_Human0.89820876
123FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89676136
124* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89638935
125* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88965675
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88671739
127TET1_21451524_ChIP-Seq_MESCs_Mouse0.88505081
128* CTCF_21964334_Chip-Seq_Bcells_Human0.87888374
129CIITA_25753668_ChIP-Seq_RAJI_Human0.87051018
130GATA3_26560356_Chip-Seq_TH2_Human0.86938912
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86567719
132* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86323005
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85201954
134FOXM1_23109430_ChIP-Seq_U2OS_Human0.85175971
135NANOG_20526341_ChIP-Seq_ESCs_Human0.84517925
136* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84289529
137P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84090434
138P300_27268052_Chip-Seq_Bcells_Human0.84008218
139FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83693314
140* FOXO3_23340844_ChIP-Seq_DLD1_Human0.81643087
141OCT4_20526341_ChIP-Seq_ESCs_Human0.81547120
142* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80846218

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.12634370
2MP0005360_urolithiasis4.87746041
3MP0009840_abnormal_foam_cell4.67086314
4MP0003806_abnormal_nucleotide_metabolis4.00447064
5MP0005085_abnormal_gallbladder_physiolo3.90559807
6MP0003656_abnormal_erythrocyte_physiolo3.87718806
7MP0005365_abnormal_bile_salt3.78092547
8MP0003303_peritoneal_inflammation3.33584527
9MP0008875_abnormal_xenobiotic_pharmacok3.15147989
10MP0003724_increased_susceptibility_to3.11083115
11MP0005083_abnormal_biliary_tract2.95088740
12MP0003763_abnormal_thymus_physiology2.91113869
13MP0005000_abnormal_immune_tolerance2.65539436
14MP0005451_abnormal_body_composition2.63967414
15MP0004147_increased_porphyrin_level2.49724042
16MP0003646_muscle_fatigue2.29100672
17MP0010329_abnormal_lipoprotein_level2.27804513
18MP0002420_abnormal_adaptive_immunity2.26793755
19MP0001819_abnormal_immune_cell2.23842123
20MP0002452_abnormal_antigen_presenting2.23477445
21MP0003172_abnormal_lysosome_physiology2.22406370
22MP0009785_altered_susceptibility_to2.20575956
23MP0003191_abnormal_cellular_cholesterol2.15513077
24MP0009333_abnormal_splenocyte_physiolog2.12501938
25MP0002148_abnormal_hypersensitivity_rea2.07166832
26MP0004130_abnormal_muscle_cell2.05193431
27MP0001666_abnormal_nutrient_absorption2.03630260
28MP0009278_abnormal_bone_marrow2.03092744
29MP0003252_abnormal_bile_duct2.02842073
30MP0000609_abnormal_liver_physiology2.00968160
31MP0002405_respiratory_system_inflammati1.95249850
32MP0005058_abnormal_lysosome_morphology1.93546578
33MP0005332_abnormal_amino_acid1.91462172
34MP0004145_abnormal_muscle_electrophysio1.90432454
35MP0002118_abnormal_lipid_homeostasis1.90026197
36MP0000747_muscle_weakness1.83480537
37MP0000716_abnormal_immune_system1.79430654
38MP0000749_muscle_degeneration1.77651742
39MP0010155_abnormal_intestine_physiology1.76193665
40MP0001533_abnormal_skeleton_physiology1.74528956
41MP0000920_abnormal_myelination1.71742734
42MP0004185_abnormal_adipocyte_glucose1.70588631
43MP0006036_abnormal_mitochondrial_physio1.67528721
44MP0005584_abnormal_enzyme/coenzyme_acti1.62975949
45MP0003828_pulmonary_edema1.60958085
46MP0003195_calcinosis1.57776547
47MP0003866_abnormal_defecation1.51914656
48MP0000703_abnormal_thymus_morphology1.51194317
49MP0005666_abnormal_adipose_tissue1.49012071
50MP0002138_abnormal_hepatobiliary_system1.46840340
51MP0002429_abnormal_blood_cell1.45063584
52MP0002269_muscular_atrophy1.44910986
53MP0000685_abnormal_immune_system1.42450663
54MP0001853_heart_inflammation1.42275521
55MP0005319_abnormal_enzyme/_coenzyme1.40587323
56MP0002396_abnormal_hematopoietic_system1.40585728
57MP0003690_abnormal_glial_cell1.39242206
58MP0004381_abnormal_hair_follicle1.37722845
59MP0005670_abnormal_white_adipose1.35335985
60MP0003868_abnormal_feces_composition1.35311410
61MP0002998_abnormal_bone_remodeling1.34617070
62MP0002933_joint_inflammation1.24877723
63MP0000604_amyloidosis1.23415241
64MP0008260_abnormal_autophagy1.22261854
65MP0002166_altered_tumor_susceptibility1.21053892
66MP0002971_abnormal_brown_adipose1.20767008
67MP0009643_abnormal_urine_homeostasis1.16303036
68MP0002132_abnormal_respiratory_system1.15938006
69MP0006082_CNS_inflammation1.15357758
70MP0004036_abnormal_muscle_relaxation1.10664621
71MP0005636_abnormal_mineral_homeostasis1.10033590
72MP0005334_abnormal_fat_pad1.09807297
73MP0000858_altered_metastatic_potential1.08922311
74MP0000598_abnormal_liver_morphology1.06489847
75MP0003329_amyloid_beta_deposits1.06433559
76MP0003436_decreased_susceptibility_to1.06182266
77MP0005166_decreased_susceptibility_to1.06075166
78MP0004808_abnormal_hematopoietic_stem1.04146789
79MP0005375_adipose_tissue_phenotype1.03357031
80MP0009763_increased_sensitivity_to1.01974597
81MP0002106_abnormal_muscle_physiology1.00768601
82MP0008469_abnormal_protein_level1.00366186
83MP0000751_myopathy0.98134846
84MP0001764_abnormal_homeostasis0.96294427
85MP0000343_altered_response_to0.94225160
86MP0002009_preneoplasia0.92348503
87MP0000759_abnormal_skeletal_muscle0.91886232
88MP0009764_decreased_sensitivity_to0.90864996
89MP0005464_abnormal_platelet_physiology0.90830196
90MP0004510_myositis0.90686862
91MP0005387_immune_system_phenotype0.90582082
92MP0001790_abnormal_immune_system0.90582082
93MP0003045_fibrosis0.90329026
94MP0004087_abnormal_muscle_fiber0.89619017
95MP0001661_extended_life_span0.86030164
96MP0005076_abnormal_cell_differentiation0.85297378
97MP0001800_abnormal_humoral_immune0.84833574
98MP0003183_abnormal_peptide_metabolism0.84406512
99MP0004947_skin_inflammation0.83524831
100MP0002254_reproductive_system_inflammat0.82627976
101MP0003718_maternal_effect0.82155138
102MP0005310_abnormal_salivary_gland0.81963087
103MP0004883_abnormal_blood_vessel0.80234053
104MP0005266_abnormal_metabolism0.79938914
105MP0001663_abnormal_digestive_system0.79650799
106MP0005535_abnormal_body_temperature0.77823681
107MP0000689_abnormal_spleen_morphology0.77804486
108MP0003091_abnormal_cell_migration0.77695893
109MP0000249_abnormal_blood_vessel0.77687548
110MP0008874_decreased_physiological_sensi0.77381079
111MP0003075_altered_response_to0.76646359
112MP0004019_abnormal_vitamin_homeostasis0.76486417
113MP0003448_altered_tumor_morphology0.75869249
114MP0006035_abnormal_mitochondrial_morpho0.75809954
115MP0005671_abnormal_response_to0.75015707
116MP0002723_abnormal_immune_serum0.74984128
117MP0003186_abnormal_redox_activity0.74660602
118MP0005164_abnormal_response_to0.74636923
119MP0002332_abnormal_exercise_endurance0.74381201
120MP0002078_abnormal_glucose_homeostasis0.74318548
121MP0005075_abnormal_melanosome_morpholog0.73402705
122MP0005025_abnormal_response_to0.72891082
123MP0009765_abnormal_xenobiotic_induced0.72830437
124MP0003221_abnormal_cardiomyocyte_apopto0.71509524
125MP0009642_abnormal_blood_homeostasis0.70156404
126MP0003795_abnormal_bone_structure0.70148782
127MP0002006_tumorigenesis0.70002350
128MP0001873_stomach_inflammation0.68622447
129MP0003705_abnormal_hypodermis_morpholog0.68242984
130MP0005369_muscle_phenotype0.66259447
131MP0005647_abnormal_sex_gland0.65822468
132MP0005390_skeleton_phenotype0.65553700
133MP0001845_abnormal_inflammatory_respons0.64366686
134MP0002419_abnormal_innate_immunity0.64305440
135MP0008961_abnormal_basal_metabolism0.64219080
136MP0002277_abnormal_respiratory_mucosa0.64165492
137MP0001851_eye_inflammation0.63413218
138MP0002722_abnormal_immune_system0.62851897
139MP0001835_abnormal_antigen_presentation0.62722960
140MP0000465_gastrointestinal_hemorrhage0.62480669
141MP0001545_abnormal_hematopoietic_system0.62445360
142MP0005397_hematopoietic_system_phenotyp0.62445360
143MP0002837_dystrophic_cardiac_calcinosis0.62215772
144MP0000750_abnormal_muscle_regeneration0.61941917
145MP0005330_cardiomyopathy0.61410174
146MP0003300_gastrointestinal_ulcer0.61309686
147MP0010368_abnormal_lymphatic_system0.60768914
148MP0002398_abnormal_bone_marrow0.60387305
149MP0003453_abnormal_keratinocyte_physiol0.60215885
150MP0009115_abnormal_fat_cell0.59425193
151MP0000015_abnormal_ear_pigmentation0.59159361
152MP0000733_abnormal_muscle_development0.59017699

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.30217788
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.28840223
3Deep venous thrombosis (HP:0002625)4.58578468
4Xanthomatosis (HP:0000991)4.57806061
5Intrahepatic cholestasis (HP:0001406)4.44315360
6Hyperlipoproteinemia (HP:0010980)4.33759137
7Myositis (HP:0100614)4.32026160
8Abnormality of macrophages (HP:0004311)4.13275873
9Recurrent abscess formation (HP:0002722)4.12380198
10Recurrent bacterial skin infections (HP:0005406)4.08405308
11Elevated erythrocyte sedimentation rate (HP:0003565)3.93534381
12Stomatitis (HP:0010280)3.69459146
13Orchitis (HP:0100796)3.66982726
14Cholelithiasis (HP:0001081)3.61866075
15Muscle fiber inclusion bodies (HP:0100299)3.61473523
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.50782864
17Optic neuritis (HP:0100653)3.46014982
18Retrobulbar optic neuritis (HP:0100654)3.46014982
19Abnormal gallbladder morphology (HP:0012437)3.45765433
20Mediastinal lymphadenopathy (HP:0100721)3.44871115
21Pustule (HP:0200039)3.44411506
22Recurrent fungal infections (HP:0002841)3.43644049
23Ketosis (HP:0001946)3.42524791
24Recurrent gram-negative bacterial infections (HP:0005420)3.39236816
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.38866492
26Abnormal gallbladder physiology (HP:0012438)3.35331513
27Cholecystitis (HP:0001082)3.35331513
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.33443566
29Exercise-induced muscle cramps (HP:0003710)3.27859153
30Exercise-induced myalgia (HP:0003738)3.27445149
31Meningitis (HP:0001287)3.26173204
32Complement deficiency (HP:0004431)3.22355575
33Recurrent skin infections (HP:0001581)3.17872994
34Hypobetalipoproteinemia (HP:0003563)3.15595747
35Nemaline bodies (HP:0003798)3.13788030
36Obstructive lung disease (HP:0006536)3.13025986
37Chronic obstructive pulmonary disease (HP:0006510)3.13025986
38Muscle fiber splitting (HP:0003555)3.12795222
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.11379275
40Hyperammonemia (HP:0001987)3.11034211
41Spontaneous hematomas (HP:0007420)3.10005129
42Reticulocytosis (HP:0001923)3.08552613
43Axonal loss (HP:0003447)3.06938046
44Increased IgE level (HP:0003212)3.06186042
45Panhypogammaglobulinemia (HP:0003139)3.05608342
46Myoglobinuria (HP:0002913)3.01196577
47Gastrointestinal infarctions (HP:0005244)3.00796256
48Abnormality of the heme biosynthetic pathway (HP:0010472)2.97908097
49Gastrointestinal inflammation (HP:0004386)2.97397933
50Increased serum ferritin (HP:0003281)2.97223345
51Hyperbilirubinemia (HP:0002904)2.96633436
52Recurrent cutaneous fungal infections (HP:0011370)2.95803430
53Chronic mucocutaneous candidiasis (HP:0002728)2.95803430
54Inflammation of the large intestine (HP:0002037)2.94334255
55Hypoalphalipoproteinemia (HP:0003233)2.91779210
56Prolonged bleeding time (HP:0003010)2.91386854
57Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.90334080
58Prolonged partial thromboplastin time (HP:0003645)2.89356590
59Recurrent viral infections (HP:0004429)2.88222800
60Colitis (HP:0002583)2.85403971
61Cellulitis (HP:0100658)2.85259851
62Abnormality of glycine metabolism (HP:0010895)2.85234260
63Abnormality of serine family amino acid metabolism (HP:0010894)2.85234260
64Vasculitis (HP:0002633)2.84813855
65T lymphocytopenia (HP:0005403)2.84661794
66Abnormality of iron homeostasis (HP:0011031)2.84221652
67Abnormality of glycolipid metabolism (HP:0010969)2.83436535
68Abnormality of liposaccharide metabolism (HP:0010968)2.83436535
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.83436535
70Hyperglycinemia (HP:0002154)2.81951094
71Hypolipoproteinemia (HP:0010981)2.81939506
72Poikilocytosis (HP:0004447)2.81697959
73Paralysis (HP:0003470)2.80417912
74Abnormality of sulfur amino acid metabolism (HP:0004339)2.77829788
75Muscle stiffness (HP:0003552)2.77727412
76Encephalitis (HP:0002383)2.76985527
77Abnormality of fatty-acid metabolism (HP:0004359)2.73787809
78Neurofibrillary tangles (HP:0002185)2.73160243
79Muscle hypertrophy of the lower extremities (HP:0008968)2.72173764
80Dysostosis multiplex (HP:0000943)2.71834722
81Agammaglobulinemia (HP:0004432)2.69983103
82Ulnar deviation of the wrist (HP:0003049)2.69792007
83Increased cerebral lipofuscin (HP:0011813)2.69449584
84Pulmonary infiltrates (HP:0002113)2.68962034
85Myopathic facies (HP:0002058)2.67400383
86Acanthocytosis (HP:0001927)2.66759050
87Gingivitis (HP:0000230)2.59727389
88Abnormality of transition element cation homeostasis (HP:0011030)2.57333028
89Abnormality of T cell number (HP:0011839)2.56471178
90Rhabdomyolysis (HP:0003201)2.56373175
91Hyporeflexia of lower limbs (HP:0002600)2.55622378
92Keratoconjunctivitis sicca (HP:0001097)2.50532013
93Epistaxis (HP:0000421)2.50341193
94Ketoacidosis (HP:0001993)2.49343816
95Hyperglycinuria (HP:0003108)2.48872233
96Microcytic anemia (HP:0001935)2.48184053
97Abnormality of purine metabolism (HP:0004352)2.48064144
98Epidermoid cyst (HP:0200040)2.46271641
99Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44485969
100Dicarboxylic aciduria (HP:0003215)2.44485969
101Abnormality of methionine metabolism (HP:0010901)2.42638565
102Abnormality of the gallbladder (HP:0005264)2.42208025
103Difficulty running (HP:0009046)2.42141741
104Chest pain (HP:0100749)2.41728055
105Gout (HP:0001997)2.41627000
106Abnormality of T cells (HP:0002843)2.41321257
107Hypoglycemic coma (HP:0001325)2.40308237
108Slow saccadic eye movements (HP:0000514)2.39509613
109Hypercholesterolemia (HP:0003124)2.38244274
110Increased neuronal autofluorescent lipopigment (HP:0002074)2.36980243
111Joint hemorrhage (HP:0005261)2.35283615
112Hypochromic anemia (HP:0001931)2.33564374
113Round ear (HP:0100830)2.33430814
114Abnormality of the common coagulation pathway (HP:0010990)2.32653675
115Distal arthrogryposis (HP:0005684)2.32350044
116Hypochromic microcytic anemia (HP:0004840)2.32321258
117Osteomyelitis (HP:0002754)2.32092634
118Fat malabsorption (HP:0002630)2.29980686
119Obstructive sleep apnea (HP:0002870)2.29230465
120Progressive muscle weakness (HP:0003323)2.28832999
121Hemoptysis (HP:0002105)2.27764707
122Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27528927
123Keratoconjunctivitis (HP:0001096)2.26695627
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24258106
125Anomalous pulmonary venous return (HP:0010772)2.22893962
126Polycythemia (HP:0001901)2.22366202
127Stridor (HP:0010307)2.20060144
128Abnormality of complement system (HP:0005339)2.19832860
129Urticaria (HP:0001025)2.19571102
130Abnormality of polysaccharide metabolism (HP:0011012)2.18557158
131Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18557158
132Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18557158
133Granulocytopenia (HP:0001913)2.18255951
134Abnormality of glutamine family amino acid metabolism (HP:0010902)2.18132787
135Type 1 muscle fiber predominance (HP:0003803)2.17785366
136Leukocytosis (HP:0001974)2.16405405
137Calf muscle hypertrophy (HP:0008981)2.16270756
138Gastrointestinal stroma tumor (HP:0100723)2.16069663
139Abnormality of the fingertips (HP:0001211)2.15624138
140Cerebral hypomyelination (HP:0006808)2.14192755
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12976037
142Systemic lupus erythematosus (HP:0002725)2.11927377
143Papilloma (HP:0012740)2.11649475
144Verrucae (HP:0200043)2.11649475
145Loss of speech (HP:0002371)2.11346283
146Amyloidosis (HP:0011034)2.10890000
147Cerebral inclusion bodies (HP:0100314)2.10094159
148Myocardial infarction (HP:0001658)2.09083299
149Lymphopenia (HP:0001888)2.08456762
150Abnormality of the Achilles tendon (HP:0005109)2.07976424
151Abnormality of T cell physiology (HP:0011840)2.07611937
152Abnormality of nucleobase metabolism (HP:0010932)2.07025052
153Episodic fever (HP:0001954)2.06866427
154Urinary glycosaminoglycan excretion (HP:0003541)2.06249015
155Mucopolysacchariduria (HP:0008155)2.06249015
156Spastic paraparesis (HP:0002313)2.04911101
157Autoimmune hemolytic anemia (HP:0001890)2.03835131
158Papilledema (HP:0001085)2.03789944
159Pulmonary embolism (HP:0002204)2.01599535
160Segmental peripheral demyelination/remyelination (HP:0003481)2.01427958
161Centrally nucleated skeletal muscle fibers (HP:0003687)2.01412365
162Purpura (HP:0000979)2.00827753
163Gingival bleeding (HP:0000225)2.00344037
164Autoimmune thrombocytopenia (HP:0001973)1.99869061
165Fatigue (HP:0012378)1.99784554
166Metabolic acidosis (HP:0001942)1.99777357
167Restrictive lung disease (HP:0002091)1.99125606
168Petechiae (HP:0000967)1.98886222
169Hematochezia (HP:0002573)1.95358055
170Recurrent bronchitis (HP:0002837)1.94833323
171Abnormality of serum amino acid levels (HP:0003112)1.93296642
172Arterial thrombosis (HP:0004420)1.92935129
173Paraparesis (HP:0002385)1.92920531
174Degeneration of the lateral corticospinal tracts (HP:0002314)1.92058473
175Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92058473
176Abnormality of the pulmonary veins (HP:0011718)1.91786966
177Acne (HP:0001061)1.91685127
178Late onset (HP:0003584)1.91671391
179Hemorrhage of the eye (HP:0011885)1.91285606
180Upper motor neuron abnormality (HP:0002127)1.91109218
181Brushfield spots (HP:0001088)1.90446744
182Neuronal loss in central nervous system (HP:0002529)1.89549203
183Hypergammaglobulinemia (HP:0010702)1.89493596
184Steatorrhea (HP:0002570)1.87621950
185Peripheral demyelination (HP:0011096)1.86929280
186Increased purine levels (HP:0004368)1.82665272
187Hyperuricemia (HP:0002149)1.82665272
188Abnormality of the intrinsic pathway (HP:0010989)1.81759478
189EMG: myopathic abnormalities (HP:0003458)1.81423050
190Asymmetric septal hypertrophy (HP:0001670)1.79143728
191Hepatic necrosis (HP:0002605)1.78080235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.88339058
2PRPF4B3.84431737
3EPHB13.74050710
4OBSCN2.96987849
5ERN12.85512203
6RIPK42.83537490
7INSRR2.67745076
8TAOK32.51080263
9TYK22.49582630
10TTN2.45733121
11CDK192.39447175
12TRIB32.28350530
13FGFR42.21130237
14FES2.20588356
15MAP3K142.07936241
16STK392.06253446
17MAP4K11.92202278
18MOS1.91138010
19MAP3K31.80559301
20IRAK41.79903125
21TNK21.78532816
22MAP2K31.69476705
23SIK31.69332244
24TAOK21.67055539
25TXK1.66459428
26MUSK1.55408179
27STK101.50887878
28KSR21.50345863
29DYRK31.50166795
30CDK121.49549205
31OXSR11.48748712
32MAP3K101.48218172
33PHKG11.39143340
34PHKG21.39143340
35MAPK111.38270348
36PKN11.37901493
37TBK11.34342006
38MAP3K71.33567496
39ICK1.33118314
40EEF2K1.29764490
41MAP3K61.28117838
42MARK21.23962915
43IRAK31.23395114
44PINK11.23088976
45MAPKAPK31.21618073
46PKN21.20743418
47PRKAA21.20117952
48JAK21.18160052
49SIK11.16182062
50SIK21.14626929
51EPHA31.13617976
52WNK41.12408872
53JAK11.12138118
54PIK3CG1.10444593
55DYRK1B1.08644574
56MARK31.04410207
57EIF2AK10.99419294
58TGFBR20.98165427
59LYN0.96447735
60MAPK120.96427287
61SMG10.96226136
62MAP2K60.94850733
63LRRK20.92323034
64BTK0.91136238
65CDC42BPA0.90440006
66PRKAA10.90145960
67CAMKK10.89455989
68MET0.89299548
69HIPK20.88810608
70FGFR30.88149995
71MAPK70.85956290
72ITK0.83134506
73NME10.82638111
74IRAK10.76484553
75IRAK20.76445586
76CSF1R0.75246139
77FLT30.74982849
78MAP3K90.74844444
79PTK60.74420093
80MAP2K40.73130668
81BMX0.72438012
82FGR0.72128367
83TESK20.72062665
84WNK10.71291499
85MAPK150.68433939
86RET0.67756841
87NLK0.67501417
88BRD40.65195137
89CHUK0.64741485
90MAP3K110.64716667
91RPS6KC10.64396559
92RPS6KL10.64396559
93TEC0.62833374
94RIPK10.62691844
95CSK0.61512586
96CAMK1D0.61174438
97GRK60.60666986
98NEK20.59115476
99KIT0.59040551
100IKBKE0.58063963
101TAOK10.57524984
102PDPK10.57352983
103MAP3K80.57180722
104PDK10.56944663
105SGK30.56562512
106STK40.54786139
107MATK0.53955448
108PDK20.53621336
109NME20.53279388
110MAP2K20.52032476
111PRKD10.51950639
112RPS6KA60.51636557
113JAK30.51186686
114TLK10.49478619
115BMPR20.49260120
116PASK0.48966411
117PRKCQ0.48864895
118FGFR20.47640938
119ZAP700.47184869
120CAMK2G0.46186489
121CDK40.44349388
122MAP3K130.42549010
123IKBKB0.42399002
124FYN0.42113334
125ERBB40.42096286
126SYK0.41367177
127MAP3K10.41231278
128PIM10.41220303
129BLK0.41197539
130MAPK40.40729825
131MAPKAPK20.39851448
132CAMKK20.37336382
133LCK0.37150283
134CAMK40.36532769
135RPS6KA20.36471635
136SGK20.35998401
137HCK0.35084076
138MAP3K20.33443666
139EIF2AK30.33368021
140MTOR0.32947732
141DYRK20.32557159
142PRKD20.31929500

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.83434466
2Nitrogen metabolism_Homo sapiens_hsa009103.69944317
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.80918968
4Folate biosynthesis_Homo sapiens_hsa007902.76723067
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.76014848
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60368115
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.57965694
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.51415113
9Arginine biosynthesis_Homo sapiens_hsa002202.48795317
10Vitamin B6 metabolism_Homo sapiens_hsa007502.47657835
11Leishmaniasis_Homo sapiens_hsa051402.47064165
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.41355656
13Primary immunodeficiency_Homo sapiens_hsa053402.37814616
14Fatty acid degradation_Homo sapiens_hsa000712.33439814
15Allograft rejection_Homo sapiens_hsa053302.30961836
16Graft-versus-host disease_Homo sapiens_hsa053322.23933368
17Autoimmune thyroid disease_Homo sapiens_hsa053202.15818604
18Propanoate metabolism_Homo sapiens_hsa006402.10693728
19Tryptophan metabolism_Homo sapiens_hsa003802.09902683
20Sulfur relay system_Homo sapiens_hsa041222.03956407
21Caffeine metabolism_Homo sapiens_hsa002321.98939525
22Acute myeloid leukemia_Homo sapiens_hsa052211.95394372
23Complement and coagulation cascades_Homo sapiens_hsa046101.94913013
24Peroxisome_Homo sapiens_hsa041461.91663634
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90397307
26T cell receptor signaling pathway_Homo sapiens_hsa046601.90290256
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.80548640
28Fatty acid metabolism_Homo sapiens_hsa012121.80103289
29Fatty acid elongation_Homo sapiens_hsa000621.78513512
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78332529
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74192364
32Tuberculosis_Homo sapiens_hsa051521.74083424
33Butanoate metabolism_Homo sapiens_hsa006501.73046138
34Histidine metabolism_Homo sapiens_hsa003401.72295373
35Type I diabetes mellitus_Homo sapiens_hsa049401.67567121
36Antigen processing and presentation_Homo sapiens_hsa046121.63893480
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.63803533
38Staphylococcus aureus infection_Homo sapiens_hsa051501.63590539
39PPAR signaling pathway_Homo sapiens_hsa033201.62190512
40beta-Alanine metabolism_Homo sapiens_hsa004101.61806385
41Hematopoietic cell lineage_Homo sapiens_hsa046401.60187151
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60101742
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58909291
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58863313
45ABC transporters_Homo sapiens_hsa020101.58587230
46Toxoplasmosis_Homo sapiens_hsa051451.56384023
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53557414
48Malaria_Homo sapiens_hsa051441.48804386
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.46872296
50Asthma_Homo sapiens_hsa053101.46607865
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46475889
52Measles_Homo sapiens_hsa051621.44794756
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42469598
54Biosynthesis of amino acids_Homo sapiens_hsa012301.41727644
55Selenocompound metabolism_Homo sapiens_hsa004501.41589625
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40118984
57Influenza A_Homo sapiens_hsa051641.40053331
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.38626475
59TNF signaling pathway_Homo sapiens_hsa046681.37722183
60Viral myocarditis_Homo sapiens_hsa054161.37692576
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34911201
62Arginine and proline metabolism_Homo sapiens_hsa003301.33943948
63Herpes simplex infection_Homo sapiens_hsa051681.32861984
64Chemical carcinogenesis_Homo sapiens_hsa052041.32761635
65Sulfur metabolism_Homo sapiens_hsa009201.30392276
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.29440103
67Chemokine signaling pathway_Homo sapiens_hsa040621.27439677
68Non-small cell lung cancer_Homo sapiens_hsa052231.26162371
69Steroid biosynthesis_Homo sapiens_hsa001001.25897831
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23152523
71Fat digestion and absorption_Homo sapiens_hsa049751.21495051
72Pyruvate metabolism_Homo sapiens_hsa006201.20131863
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17722054
74Glycosaminoglycan degradation_Homo sapiens_hsa005311.16266911
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14733074
76Hepatitis B_Homo sapiens_hsa051611.14611054
77Carbon metabolism_Homo sapiens_hsa012001.14444492
78Bile secretion_Homo sapiens_hsa049761.13265376
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12979733
80Chronic myeloid leukemia_Homo sapiens_hsa052201.10664909
81VEGF signaling pathway_Homo sapiens_hsa043701.10452068
82Platelet activation_Homo sapiens_hsa046111.08093494
83Pancreatic cancer_Homo sapiens_hsa052121.07269576
84Leukocyte transendothelial migration_Homo sapiens_hsa046701.05711012
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04497501
86Legionellosis_Homo sapiens_hsa051341.01424538
87Rheumatoid arthritis_Homo sapiens_hsa053231.00797384
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99983371
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.99280997
90Pentose phosphate pathway_Homo sapiens_hsa000300.99107851
91Renal cell carcinoma_Homo sapiens_hsa052110.99012700
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.98746496
93Retinol metabolism_Homo sapiens_hsa008300.97182662
94Linoleic acid metabolism_Homo sapiens_hsa005910.96861426
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95062657
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95054237
97Starch and sucrose metabolism_Homo sapiens_hsa005000.93166954
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.92685762
99Apoptosis_Homo sapiens_hsa042100.91715423
100Glycerolipid metabolism_Homo sapiens_hsa005610.89543307
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89018793
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86855128
103mTOR signaling pathway_Homo sapiens_hsa041500.84518613
104GnRH signaling pathway_Homo sapiens_hsa049120.81978576
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.80339553
106Phagosome_Homo sapiens_hsa041450.80165976
107FoxO signaling pathway_Homo sapiens_hsa040680.79841797
108Vitamin digestion and absorption_Homo sapiens_hsa049770.79326268
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.76540020
110HTLV-I infection_Homo sapiens_hsa051660.76516997
111African trypanosomiasis_Homo sapiens_hsa051430.76215507
112Insulin resistance_Homo sapiens_hsa049310.75879218
113Prolactin signaling pathway_Homo sapiens_hsa049170.75086475
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72312664
115Epstein-Barr virus infection_Homo sapiens_hsa051690.72289728
116Endocytosis_Homo sapiens_hsa041440.71154010
117Inositol phosphate metabolism_Homo sapiens_hsa005620.71148365
118Lysine degradation_Homo sapiens_hsa003100.70389566
119Choline metabolism in cancer_Homo sapiens_hsa052310.69759330
120Shigellosis_Homo sapiens_hsa051310.69165820
121MAPK signaling pathway_Homo sapiens_hsa040100.69101082
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68851506
123Phenylalanine metabolism_Homo sapiens_hsa003600.68530105
124HIF-1 signaling pathway_Homo sapiens_hsa040660.68000468
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.66946288
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64530521
127Viral carcinogenesis_Homo sapiens_hsa052030.63529355
128Endometrial cancer_Homo sapiens_hsa052130.63058382
129Salmonella infection_Homo sapiens_hsa051320.62452148
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62297492
131Tyrosine metabolism_Homo sapiens_hsa003500.62103872
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61797382
133Glutathione metabolism_Homo sapiens_hsa004800.61170409
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59632575
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.58894018
136Ether lipid metabolism_Homo sapiens_hsa005650.58855512
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58515916
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56102035
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.54915960
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54168011
141Dorso-ventral axis formation_Homo sapiens_hsa043200.53925647
142AMPK signaling pathway_Homo sapiens_hsa041520.53533466
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51019083
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50335830
145Long-term potentiation_Homo sapiens_hsa047200.49155738
146Lysosome_Homo sapiens_hsa041420.49004341
147Colorectal cancer_Homo sapiens_hsa052100.48934527
148Amoebiasis_Homo sapiens_hsa051460.48832749
149Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47788522
150Metabolic pathways_Homo sapiens_hsa011000.47018366
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46994328
152Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46729439
153Regulation of autophagy_Homo sapiens_hsa041400.45112617
154Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43356934
155Circadian rhythm_Homo sapiens_hsa047100.43255033
156ErbB signaling pathway_Homo sapiens_hsa040120.43236199
157Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42442282
158Fatty acid biosynthesis_Homo sapiens_hsa000610.41992762
159Type II diabetes mellitus_Homo sapiens_hsa049300.41907904
160Systemic lupus erythematosus_Homo sapiens_hsa053220.38644638
161Other glycan degradation_Homo sapiens_hsa005110.34151652
162B cell receptor signaling pathway_Homo sapiens_hsa046620.31074981
163Fructose and mannose metabolism_Homo sapiens_hsa000510.25274323
164Glucagon signaling pathway_Homo sapiens_hsa049220.24839793
165Insulin signaling pathway_Homo sapiens_hsa049100.23556306
166Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19611954
167Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17984362
168Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17878331
169One carbon pool by folate_Homo sapiens_hsa006700.12939344
170Pertussis_Homo sapiens_hsa051330.10730509
171Prion diseases_Homo sapiens_hsa050200.08826535
172Ovarian steroidogenesis_Homo sapiens_hsa049130.08028037
173Hepatitis C_Homo sapiens_hsa051600.07680017
174Osteoclast differentiation_Homo sapiens_hsa043800.07471307
175Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.04534306
176Arachidonic acid metabolism_Homo sapiens_hsa005900.04488456
177Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04154881
178Sphingolipid metabolism_Homo sapiens_hsa006000.01894636
179NF-kappa B signaling pathway_Homo sapiens_hsa040640.01836977
180Notch signaling pathway_Homo sapiens_hsa043300.01796273

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