ARRB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.53811647
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.53811647
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.53811647
4modulation by symbiont of host immune response (GO:0052553)5.53811647
5positive regulation by symbiont of host defense response (GO:0052509)5.53811647
6modulation by symbiont of host defense response (GO:0052031)5.53811647
7positive regulation of gamma-delta T cell activation (GO:0046645)5.32197417
8leukocyte aggregation (GO:0070486)5.15673384
9detection of other organism (GO:0098543)5.08149328
10regulation of B cell receptor signaling pathway (GO:0050855)4.96283714
11detection of bacterium (GO:0016045)4.87424183
12cellular extravasation (GO:0045123)4.60575700
13regulation of interferon-beta biosynthetic process (GO:0045357)4.46383805
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.33671777
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.33671777
16response to peptidoglycan (GO:0032494)4.28827024
17detection of external biotic stimulus (GO:0098581)4.28303051
18macrophage activation involved in immune response (GO:0002281)4.11435510
19detection of molecule of bacterial origin (GO:0032490)4.10656521
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.08417537
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.06962430
22neutrophil activation involved in immune response (GO:0002283)4.04719769
23respiratory burst (GO:0045730)4.01179265
24positive thymic T cell selection (GO:0045059)4.00394692
25regulation of gamma-delta T cell differentiation (GO:0045586)3.94745128
26antigen processing and presentation of endogenous antigen (GO:0019883)3.93657412
27response to muramyl dipeptide (GO:0032495)3.85506569
28detection of biotic stimulus (GO:0009595)3.83405186
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.83281202
30immunoglobulin mediated immune response (GO:0016064)3.83223825
31tolerance induction (GO:0002507)3.82773165
32regulation of gamma-delta T cell activation (GO:0046643)3.81539034
33response to host immune response (GO:0052572)3.79409797
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.79409797
35negative regulation of erythrocyte differentiation (GO:0045647)3.78903076
36positive regulation of B cell differentiation (GO:0045579)3.76553893
37* negative regulation of lymphocyte mediated immunity (GO:0002707)3.76040441
38negative regulation of granulocyte differentiation (GO:0030853)3.75702361
39mannose metabolic process (GO:0006013)3.74572509
40negative thymic T cell selection (GO:0045060)3.67135367
41negative regulation of T cell mediated immunity (GO:0002710)3.61765957
42response to host defenses (GO:0052200)3.59634996
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.59634996
44response to host (GO:0075136)3.59634996
45negative T cell selection (GO:0043383)3.57414701
46neutrophil activation (GO:0042119)3.52812227
47leukocyte cell-cell adhesion (GO:0007159)3.49809059
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.49182035
49* negative regulation of leukocyte mediated immunity (GO:0002704)3.48736082
50positive regulation of antigen processing and presentation (GO:0002579)3.48258743
51leukocyte migration involved in inflammatory response (GO:0002523)3.45244860
52regulation of B cell differentiation (GO:0045577)3.44804099
53granulocyte activation (GO:0036230)3.44492915
54positive regulation of interferon-alpha production (GO:0032727)3.43811151
55regulation of tolerance induction (GO:0002643)3.42790132
56B cell receptor signaling pathway (GO:0050853)3.40928866
57myeloid cell activation involved in immune response (GO:0002275)3.39399502
58T cell migration (GO:0072678)3.38580330
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.34762640
60regulation of interferon-alpha production (GO:0032647)3.31258436
61positive regulation of mast cell degranulation (GO:0043306)3.30111788
62positive regulation of mast cell activation involved in immune response (GO:0033008)3.30111788
63production of molecular mediator involved in inflammatory response (GO:0002532)3.29012228
64regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.27652072
65neutrophil mediated immunity (GO:0002446)3.26675321
66cellular response to interleukin-15 (GO:0071350)3.26245435
67thymic T cell selection (GO:0045061)3.26217941
68microglial cell activation (GO:0001774)3.24900336
69leukocyte degranulation (GO:0043299)3.23117874
70response to fungus (GO:0009620)3.21608423
71defense response to protozoan (GO:0042832)3.21588944
72lipopolysaccharide-mediated signaling pathway (GO:0031663)3.18379735
73cellular response to type I interferon (GO:0071357)3.16631779
74type I interferon signaling pathway (GO:0060337)3.16631779
75regulation of T-helper 2 cell differentiation (GO:0045628)3.14739906
76positive regulation of mast cell activation (GO:0033005)3.14005801
77NIK/NF-kappaB signaling (GO:0038061)3.13977198
78activated T cell proliferation (GO:0050798)3.12987425
79germinal center formation (GO:0002467)3.12745240
80regulation of regulated secretory pathway (GO:1903305)3.12156745
81regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10720902
82positive T cell selection (GO:0043368)3.09991139
83neutrophil chemotaxis (GO:0030593)3.08833008
84negative regulation of phagocytosis (GO:0050765)3.08726750
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06853966
86negative regulation of cytokine production involved in immune response (GO:0002719)3.06564041
87positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.06034929
88positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.04979158
89regulation of interleukin-12 biosynthetic process (GO:0045075)3.02098912
90myeloid leukocyte mediated immunity (GO:0002444)3.00358728
91defense response to fungus (GO:0050832)3.00126576
92pinocytosis (GO:0006907)2.99023661
93neutrophil migration (GO:1990266)2.98854403
94JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.98249587
95negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96725238
96* negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96085551
97* negative regulation of cell killing (GO:0031342)2.96085551
98regulation of mast cell degranulation (GO:0043304)2.95410807
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93582453
100positive regulation of cellular amide metabolic process (GO:0034250)2.92721145
101regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.92209525
102T cell selection (GO:0045058)2.91612309
103negative regulation of type 2 immune response (GO:0002829)2.90861113
104myeloid leukocyte activation (GO:0002274)2.89718356
105B cell mediated immunity (GO:0019724)2.89457635
106regulation of leukocyte degranulation (GO:0043300)2.89445569
107positive regulation of tolerance induction (GO:0002645)2.89299862
108response to protozoan (GO:0001562)2.89272253
109positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.88533663
110interferon-gamma production (GO:0032609)2.88509110
111regulation of alpha-beta T cell proliferation (GO:0046640)2.87984331
112regulation of integrin activation (GO:0033623)2.86021124
113regulation of antigen processing and presentation (GO:0002577)2.84762916
114regulation of myeloid leukocyte mediated immunity (GO:0002886)2.81725157
115antigen processing and presentation via MHC class Ib (GO:0002475)2.78247459
116regulation of T cell tolerance induction (GO:0002664)2.77265244
117response to interleukin-15 (GO:0070672)2.76814754
118* negative regulation of interleukin-6 production (GO:0032715)2.76766941
119* negative regulation of interleukin-12 production (GO:0032695)2.76556372
120regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76211901
121macrophage activation (GO:0042116)2.74785160
122regulation of mast cell activation involved in immune response (GO:0033006)2.74268597
123interferon-gamma-mediated signaling pathway (GO:0060333)2.72983680
124actin nucleation (GO:0045010)2.71387802
125myeloid dendritic cell activation (GO:0001773)2.70581635
126response to laminar fluid shear stress (GO:0034616)2.69577996
127positive regulation of lamellipodium assembly (GO:0010592)2.68152381
128regulation of mast cell activation (GO:0033003)2.67671008
129regulation of phagocytosis (GO:0050764)2.67214091
130I-kappaB phosphorylation (GO:0007252)2.66259553
131regulation of granulocyte differentiation (GO:0030852)2.65104188
132granulocyte chemotaxis (GO:0071621)2.64534281
133antigen receptor-mediated signaling pathway (GO:0050851)2.63866505
134leukotriene metabolic process (GO:0006691)2.63634097
135T cell proliferation (GO:0042098)2.63369581
136response to type I interferon (GO:0034340)2.63053854
137mature B cell differentiation (GO:0002335)2.62946432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.20073479
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.80283126
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.74083006
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.73172453
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.58063413
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.53344437
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.41996682
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.31730342
9VDR_21846776_ChIP-Seq_THP-1_Human3.28165233
10MYC_22102868_ChIP-Seq_BL_Human3.18721148
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.13752622
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06886362
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04301553
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.94817661
15E2F7_22180533_ChIP-Seq_HELA_Human2.84793550
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.54544448
17BRD4_27068464_Chip-Seq_AML-cells_Mouse2.52651080
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49090212
19* MAF_26560356_Chip-Seq_TH1_Human2.48983595
20SCL_19346495_ChIP-Seq_HPC-7_Human2.48360378
21TCF7_22412390_ChIP-Seq_EML_Mouse2.46271167
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46212523
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44227077
24VDR_24763502_ChIP-Seq_THP-1_Human2.37657063
25SPI1_23127762_ChIP-Seq_K562_Human2.33330862
26* SPI1_23547873_ChIP-Seq_NB4_Human2.28992698
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.28310830
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.22489840
29* UTX_26944678_Chip-Seq_JUKART_Human2.20946259
30MYB_26560356_Chip-Seq_TH2_Human2.20803398
31RUNX_20019798_ChIP-Seq_JUKART_Human2.19781061
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.17795972
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.13448954
34STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11706201
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08914583
36KDM2B_26808549_Chip-Seq_DND41_Human2.08162850
37FOXM1_23109430_ChIP-Seq_U2OS_Human2.04571072
38KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00836357
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00064955
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00007777
41MYB_26560356_Chip-Seq_TH1_Human1.99508400
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98814067
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92652505
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91199200
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87941681
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86164041
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.77301509
48* MAF_26560356_Chip-Seq_TH2_Human1.68023455
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67159835
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66560556
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58843982
52* PU_27001747_Chip-Seq_BMDM_Mouse1.54608814
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52848535
54LXR_22292898_ChIP-Seq_THP-1_Human1.51277692
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48560155
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45376840
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42253986
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41841963
59GATA3_27048872_Chip-Seq_THYMUS_Human1.41187704
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.38706089
61* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38700115
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33861642
63* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29448004
64* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28715986
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28555513
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27590352
67* KDM2B_26808549_Chip-Seq_JURKAT_Human1.25839428
68* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23359415
69* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21161355
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20955781
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16515403
72* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15551751
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13834945
74VDR_24787735_ChIP-Seq_THP-1_Human1.12781856
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09318035
76NCOR1_26117541_ChIP-Seq_K562_Human1.07580169
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05942373
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03964744
79* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02950713
80GATA1_19941826_ChIP-Seq_K562_Human1.02213546
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.00967983
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.00664602
83* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00092885
84TFEB_21752829_ChIP-Seq_HELA_Human0.99218979
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97946219
86* SPI1_20517297_ChIP-Seq_HL60_Human0.97689308
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97267485
88* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96259035
89CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95291670
90P68_20966046_ChIP-Seq_HELA_Human0.94472301
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93606008
92KDM2B_26808549_Chip-Seq_K562_Human0.92685798
93SMAD_19615063_ChIP-ChIP_OVARY_Human0.92553587
94CIITA_25753668_ChIP-Seq_RAJI_Human0.92489301
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91729699
96GATA3_26560356_Chip-Seq_TH2_Human0.91475307
97GATA2_19941826_ChIP-Seq_K562_Human0.90073932
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89920149
99RACK7_27058665_Chip-Seq_MCF-7_Human0.89462973
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89194299
101* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88993402
102P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84994654
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84747349
104CTCF_21964334_ChIP-Seq_BJAB-B_Human0.83895222
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83744392
106BCL6_27268052_Chip-Seq_Bcells_Human0.82403931
107BCOR_27268052_Chip-Seq_Bcells_Human0.81321663
108IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79212562
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.76859043
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76167760

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.18009074
2MP0003436_decreased_susceptibility_to3.55575904
3MP0001835_abnormal_antigen_presentation3.28320637
4MP0005058_abnormal_lysosome_morphology3.28106554
5MP0000685_abnormal_immune_system2.85492174
6MP0002419_abnormal_innate_immunity2.83863917
7MP0003172_abnormal_lysosome_physiology2.72315487
8MP0001800_abnormal_humoral_immune2.71217378
9MP0005387_immune_system_phenotype2.68938031
10MP0001790_abnormal_immune_system2.68938031
11MP0005000_abnormal_immune_tolerance2.68642570
12MP0003300_gastrointestinal_ulcer2.64480846
13MP0006082_CNS_inflammation2.62153505
14MP0005671_abnormal_response_to2.58920062
15MP0000569_abnormal_digit_pigmentation2.57782548
16MP0009278_abnormal_bone_marrow2.57092922
17MP0002452_abnormal_antigen_presenting2.55703581
18MP0005025_abnormal_response_to2.54543990
19MP0005464_abnormal_platelet_physiology2.52209585
20MP0004510_myositis2.42217322
21* MP0002723_abnormal_immune_serum2.42023327
22* MP0002420_abnormal_adaptive_immunity2.39346236
23* MP0001819_abnormal_immune_cell2.39004848
24MP0009785_altered_susceptibility_to2.38753417
25MP0002405_respiratory_system_inflammati2.20063190
26MP0002398_abnormal_bone_marrow2.08876545
27MP0002148_abnormal_hypersensitivity_rea2.08769104
28MP0002396_abnormal_hematopoietic_system2.04167813
29MP0003763_abnormal_thymus_physiology1.99223423
30MP0003183_abnormal_peptide_metabolism1.97536362
31MP0000716_abnormal_immune_system1.96222660
32MP0008260_abnormal_autophagy1.89761111
33MP0003191_abnormal_cellular_cholesterol1.88475121
34MP0004947_skin_inflammation1.87516953
35MP0002166_altered_tumor_susceptibility1.87086230
36MP0009840_abnormal_foam_cell1.86377217
37MP0001533_abnormal_skeleton_physiology1.86184843
38MP0009333_abnormal_splenocyte_physiolog1.84509802
39MP0000689_abnormal_spleen_morphology1.81533405
40MP0002722_abnormal_immune_system1.73366605
41MP0001873_stomach_inflammation1.72203872
42* MP0001845_abnormal_inflammatory_respons1.69934574
43MP0002132_abnormal_respiratory_system1.68198424
44MP0005397_hematopoietic_system_phenotyp1.66847494
45MP0001545_abnormal_hematopoietic_system1.66847494
46MP0005174_abnormal_tail_pigmentation1.65796823
47MP0005076_abnormal_cell_differentiation1.65600583
48MP0002429_abnormal_blood_cell1.63697041
49MP0003724_increased_susceptibility_to1.62649840
50MP0004808_abnormal_hematopoietic_stem1.55951738
51MP0010155_abnormal_intestine_physiology1.53199142
52MP0000465_gastrointestinal_hemorrhage1.51767931
53MP0001853_heart_inflammation1.51627668
54MP0005310_abnormal_salivary_gland1.50499817
55MP0001851_eye_inflammation1.49828122
56MP0000703_abnormal_thymus_morphology1.47646658
57MP0003448_altered_tumor_morphology1.46317433
58MP0002006_tumorigenesis1.44715459
59MP0005451_abnormal_body_composition1.42665552
60MP0003075_altered_response_to1.35254145
61* MP0008469_abnormal_protein_level1.32402735
62MP0010307_abnormal_tumor_latency1.31024367
63MP0000858_altered_metastatic_potential1.27489822
64MP0000343_altered_response_to1.23809836
65MP0002933_joint_inflammation1.18841016
66MP0004883_abnormal_blood_vessel1.18048488
67MP0003566_abnormal_cell_adhesion1.17546568
68MP0000604_amyloidosis1.15269327
69MP0004381_abnormal_hair_follicle1.10433926
70MP0000490_abnormal_crypts_of1.06693593
71MP0003866_abnormal_defecation1.04465336
72MP0002998_abnormal_bone_remodeling1.03301621
73MP0000015_abnormal_ear_pigmentation1.00512723
74MP0008004_abnormal_stomach_pH0.98542303
75MP0002138_abnormal_hepatobiliary_system0.97866011
76MP0010352_gastrointestinal_tract_polyps0.95318127
77MP0005023_abnormal_wound_healing0.95240864
78MP0008961_abnormal_basal_metabolism0.92611656
79MP0005164_abnormal_response_to0.92471751
80MP0000371_diluted_coat_color0.92459120
81MP0004185_abnormal_adipocyte_glucose0.87708547
82MP0003806_abnormal_nucleotide_metabolis0.87151778
83MP0005166_decreased_susceptibility_to0.85131196
84MP0003705_abnormal_hypodermis_morpholog0.83799367
85MP0009764_decreased_sensitivity_to0.81987275
86MP0009763_increased_sensitivity_to0.78332502
87MP0001986_abnormal_taste_sensitivity0.76857933
88MP0002019_abnormal_tumor_incidence0.76781513
89MP0003656_abnormal_erythrocyte_physiolo0.75892592
90MP0005167_abnormal_blood-brain_barrier0.73627397
91MP0005390_skeleton_phenotype0.72865395
92MP0003045_fibrosis0.71376959
93MP0003828_pulmonary_edema0.71316529
94MP0003453_abnormal_keratinocyte_physiol0.70971837
95MP0009765_abnormal_xenobiotic_induced0.70437079
96MP0000249_abnormal_blood_vessel0.68775169
97MP0003091_abnormal_cell_migration0.68687097
98MP0008874_decreased_physiological_sensi0.67311129
99MP0002928_abnormal_bile_duct0.67244287
100MP0003690_abnormal_glial_cell0.66669034
101MP0001915_intracranial_hemorrhage0.62339719
102MP0001663_abnormal_digestive_system0.62207452
103MP0004130_abnormal_muscle_cell0.62110776
104MP0000920_abnormal_myelination0.61579956
105MP0000609_abnormal_liver_physiology0.61384708
106MP0003329_amyloid_beta_deposits0.59863673
107MP0005075_abnormal_melanosome_morpholog0.57367643
108MP0003795_abnormal_bone_structure0.56743687
109MP0008873_increased_physiological_sensi0.55208073
110MP0005319_abnormal_enzyme/_coenzyme0.54753218
111MP0002254_reproductive_system_inflammat0.54652407
112MP0002277_abnormal_respiratory_mucosa0.54413296
113MP0000313_abnormal_cell_death0.54200837
114MP0005621_abnormal_cell_physiology0.53022272
115MP0004858_abnormal_nervous_system0.52357804
116MP0000598_abnormal_liver_morphology0.50927452
117MP0005381_digestive/alimentary_phenotyp0.47732344
118MP0002009_preneoplasia0.46102889
119MP0005377_hearing/vestibular/ear_phenot0.46102440
120MP0003878_abnormal_ear_physiology0.46102440

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.25509982
2Eczematoid dermatitis (HP:0000976)5.93269014
3Recurrent bacterial skin infections (HP:0005406)5.51888123
4Systemic lupus erythematosus (HP:0002725)4.98652317
5Recurrent gram-negative bacterial infections (HP:0005420)4.78988812
6Recurrent fungal infections (HP:0002841)4.25618255
7Gastrointestinal infarctions (HP:0005244)3.99310803
8Abnormality of macrophages (HP:0004311)3.85683705
9Mediastinal lymphadenopathy (HP:0100721)3.79571168
10Glomerulonephritis (HP:0000099)3.70868392
11Dysostosis multiplex (HP:0000943)3.69751065
12Recurrent skin infections (HP:0001581)3.69020442
13Increased cerebral lipofuscin (HP:0011813)3.67912936
14Chronic obstructive pulmonary disease (HP:0006510)3.65046560
15Obstructive lung disease (HP:0006536)3.65046560
16Encephalitis (HP:0002383)3.62440747
17Keratoconjunctivitis sicca (HP:0001097)3.52771699
18Myositis (HP:0100614)3.51182486
19Elevated erythrocyte sedimentation rate (HP:0003565)3.47989618
20Recurrent viral infections (HP:0004429)3.45105172
21Vacuolated lymphocytes (HP:0001922)3.43685330
22Gingivitis (HP:0000230)3.41145073
23Pustule (HP:0200039)3.30813218
24Hypochromic microcytic anemia (HP:0004840)3.29364306
25Keratoconjunctivitis (HP:0001096)3.24609313
26Stomatitis (HP:0010280)3.22899842
27Chronic mucocutaneous candidiasis (HP:0002728)3.17070608
28Recurrent cutaneous fungal infections (HP:0011370)3.17070608
29Increased neuronal autofluorescent lipopigment (HP:0002074)3.12980532
30Hypochromic anemia (HP:0001931)3.07812720
31Abnormality of liposaccharide metabolism (HP:0010968)3.04201648
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.04201648
33Abnormality of glycolipid metabolism (HP:0010969)3.04201648
34Spontaneous hematomas (HP:0007420)3.00742396
35Cellulitis (HP:0100658)2.98387445
36Inflammation of the large intestine (HP:0002037)2.96703523
37Episodic fever (HP:0001954)2.96024030
38Amyloidosis (HP:0011034)2.92625278
39Colitis (HP:0002583)2.92148099
40Gastrointestinal inflammation (HP:0004386)2.91109421
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.88564661
42Mucopolysacchariduria (HP:0008155)2.87728543
43Urinary glycosaminoglycan excretion (HP:0003541)2.87728543
44Autoimmune thrombocytopenia (HP:0001973)2.87711345
45IgM deficiency (HP:0002850)2.83053651
46Abnormality of polysaccharide metabolism (HP:0011012)2.81158340
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.81158340
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.81158340
49Nasal polyposis (HP:0100582)2.76889357
50Periodontitis (HP:0000704)2.76857365
51Meningitis (HP:0001287)2.75641980
52Disinhibition (HP:0000734)2.67220594
53Orchitis (HP:0100796)2.66947299
54Hematochezia (HP:0002573)2.61930498
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.60725647
56Pulmonary embolism (HP:0002204)2.60308874
57Anorexia (HP:0002039)2.58542688
58Prolonged bleeding time (HP:0003010)2.58430388
59Increased IgM level (HP:0003496)2.58180958
60Chronic otitis media (HP:0000389)2.57986386
61Leukocytosis (HP:0001974)2.56902812
62Purpura (HP:0000979)2.56159144
63Abnormality of the nasal mucosa (HP:0000433)2.55590169
64T lymphocytopenia (HP:0005403)2.48227772
65Abnormality of the fingertips (HP:0001211)2.48159402
66Abnormality of complement system (HP:0005339)2.47881075
67Cerebral aneurysm (HP:0004944)2.47169833
68Complement deficiency (HP:0004431)2.45866390
69Vasculitis (HP:0002633)2.44024616
70Abnormality of T cell number (HP:0011839)2.41677441
71Increased serum ferritin (HP:0003281)2.38488675
72Urticaria (HP:0001025)2.36441950
73Loss of speech (HP:0002371)2.36252899
74Microcytic anemia (HP:0001935)2.32557797
75Thoracic kyphosis (HP:0002942)2.32356026
76Increased IgE level (HP:0003212)2.31120377
77Peritonitis (HP:0002586)2.30272159
78Epistaxis (HP:0000421)2.29484687
79Hepatosplenomegaly (HP:0001433)2.26545325
80Optic neuritis (HP:0100653)2.26405550
81Retrobulbar optic neuritis (HP:0100654)2.26405550
82Gangrene (HP:0100758)2.24759460
83Nephritis (HP:0000123)2.23850141
84Gingival bleeding (HP:0000225)2.23389993
85Panhypogammaglobulinemia (HP:0003139)2.23352657
86Eosinophilia (HP:0001880)2.21624482
87Abnormal platelet function (HP:0011869)2.21557523
88Impaired platelet aggregation (HP:0003540)2.21557523
89Sepsis (HP:0100806)2.20733530
90Hypergammaglobulinemia (HP:0010702)2.20435822
91Abnormality of the pleura (HP:0002103)2.19483006
92Abnormality of T cells (HP:0002843)2.18174058
93Arterial thrombosis (HP:0004420)2.17745197
94Abnormality of iron homeostasis (HP:0011031)2.16374454
95Interstitial pulmonary disease (HP:0006530)2.14610987
96Agnosia (HP:0010524)2.12397753
97Spondylolisthesis (HP:0003302)2.11187884
98Chest pain (HP:0100749)2.09863792
99Axonal loss (HP:0003447)2.08455221
100Slow saccadic eye movements (HP:0000514)2.07973384
101Increased density of long bones (HP:0006392)2.06020976
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05646617
103Abnormality of the thoracic spine (HP:0100711)2.05487882
104Glomerulopathy (HP:0100820)2.04974224
105Myocardial infarction (HP:0001658)2.04150298
106Pulmonary infiltrates (HP:0002113)2.03992547
107Acne (HP:0001061)2.03354500
108Petechiae (HP:0000967)2.02169298
109Hemoptysis (HP:0002105)2.01997311
110Abnormality of the peritoneum (HP:0002585)2.01576324
111Osteomyelitis (HP:0002754)2.00780613
112Abnormality of the endocardium (HP:0004306)1.99872307
113Vertigo (HP:0002321)1.99365477
114Premature loss of primary teeth (HP:0006323)1.96480005
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91568937
116Skin ulcer (HP:0200042)1.91106585
117Agammaglobulinemia (HP:0004432)1.88625207
118Abnormality of eosinophils (HP:0001879)1.88005857
119Verrucae (HP:0200043)1.87643345
120Papilloma (HP:0012740)1.87643345
121Granulocytopenia (HP:0001913)1.87542434
122Polyneuropathy (HP:0001271)1.86771403
123Recurrent bronchitis (HP:0002837)1.85980126
124Thyroiditis (HP:0100646)1.85032958
125Abnormality of T cell physiology (HP:0011840)1.83378865
126Segmental peripheral demyelination/remyelination (HP:0003481)1.83027770
127Thrombocytosis (HP:0001894)1.80686009
128Keratitis (HP:0000491)1.80416160
129Abnormal platelet volume (HP:0011876)1.80228747
130Acute hepatic failure (HP:0006554)1.79331684
131Frequent falls (HP:0002359)1.79113073
132Abnormality of cells of the lymphoid lineage (HP:0012140)1.78958756
133Lymphopenia (HP:0001888)1.78337404
134Upper motor neuron abnormality (HP:0002127)1.77816699
135Diminished motivation (HP:0000745)1.76638620
136Cheilitis (HP:0100825)1.76483026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.02271867
2TYK22.84952568
3BLK2.75806261
4PRPF4B2.75090800
5IRAK42.66672577
6TXK2.33751240
7TRIB32.30609432
8RIPK42.28103594
9ZAP702.24663541
10TGFBR22.24280233
11ERN12.14420432
12STK102.08299208
13TBK12.07966676
14FES2.03901547
15GRK61.94551062
16MAP3K101.94023931
17KIT1.91583464
18CSK1.90603956
19SIK21.88171006
20JAK31.87504200
21CSF1R1.87125555
22PKN21.84510127
23MAP3K31.75985862
24CAMK1D1.72415032
25HCK1.71504914
26EEF2K1.70115454
27EPHB11.69091637
28CDK121.64745929
29JAK11.63828421
30IKBKE1.62334858
31MAP3K141.59520205
32BTK1.52298349
33MAP3K131.51610570
34ITK1.50823981
35MAP2K31.48426001
36CAMK1G1.43234747
37TAOK31.41979423
38SIK31.40562924
39FGR1.40011015
40SYK1.38370246
41LCK1.35397771
42MAP3K11.30075073
43IKBKB1.24350446
44PTK61.20064883
45CLK11.19058497
46FGFR41.17384943
47TTN1.15115515
48JAK21.14931145
49TAOK21.14502928
50MARK21.06946023
51IRAK31.03217053
52MARK31.00452114
53PAK40.99372235
54TEC0.96710794
55ALK0.95883189
56RIPK10.93169910
57YES10.93156155
58IRAK20.92850756
59SMG10.92407269
60LRRK20.91720894
61FGFR30.91048903
62LYN0.88856679
63PIM10.87452137
64IRAK10.82899758
65TESK20.82219734
66PDPK10.81146652
67NEK20.76956635
68RPS6KA40.76821913
69CHUK0.75624634
70MAP3K110.75438484
71CDC42BPA0.75155598
72SCYL20.74787975
73MAPK120.74413034
74TAOK10.73304157
75CDK190.71905457
76CDK60.70075212
77PRKCH0.69035639
78BMX0.69034228
79BMPR20.67699567
80TLK10.65337580
81MATK0.62903518
82EGFR0.61477714
83CDK40.61422645
84SIK10.60308813
85MAPK70.60125891
86CAMKK20.60095261
87MAP3K90.58016703
88DYRK1B0.56489279
89NEK90.54486122
90STK110.54173483
91MAP3K60.53431750
92DMPK0.52909300
93KDR0.51922306
94PDK10.50985734
95STK40.50175610
96SGK30.47762157
97MAP3K50.47229337
98ICK0.47134326
99TNK20.46751150
100TRPM70.46106232
101MAP2K40.46046856
102FYN0.45876002
103RPS6KA60.45726068
104CAMKK10.45694061
105HIPK20.45265227
106MAP3K80.41970490
107MAP2K60.41797239
108RPS6KL10.41697441
109RPS6KC10.41697441
110KSR20.41068576
111DAPK20.40834451
112RPS6KA20.39972093
113MAPKAPK20.38868506
114MAP3K20.38634402
115RET0.37855474
116FLT30.37786629
117MAPK110.37320436
118GRK70.36034442
119PDGFRB0.35812987
120PRKD20.35755976
121MOS0.34858060
122ABL10.34465603
123MAPK40.34365943
124MAP3K70.34331865
125PRKCQ0.33704599
126CDK90.32998598
127PTK2B0.31897625
128MAP2K20.31401160
129RAF10.30174941
130PRKG20.30088302
131KSR10.28274227
132STK380.27969376
133NLK0.27860267

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.42264632
2Leishmaniasis_Homo sapiens_hsa051402.96419265
3Osteoclast differentiation_Homo sapiens_hsa043802.66216256
4Other glycan degradation_Homo sapiens_hsa005112.41468949
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.33584026
6B cell receptor signaling pathway_Homo sapiens_hsa046622.29496817
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.20541212
8Autoimmune thyroid disease_Homo sapiens_hsa053202.13756670
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02791530
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89161566
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.87397802
12Pertussis_Homo sapiens_hsa051331.86131198
13Measles_Homo sapiens_hsa051621.85407418
14Primary immunodeficiency_Homo sapiens_hsa053401.85353996
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.83056151
16T cell receptor signaling pathway_Homo sapiens_hsa046601.76748249
17Tuberculosis_Homo sapiens_hsa051521.73690271
18Lysosome_Homo sapiens_hsa041421.73684510
19Type I diabetes mellitus_Homo sapiens_hsa049401.72286251
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.72273946
21Antigen processing and presentation_Homo sapiens_hsa046121.65750241
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64852780
23* Chemokine signaling pathway_Homo sapiens_hsa040621.56766513
24Toxoplasmosis_Homo sapiens_hsa051451.53856306
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51736758
26Hematopoietic cell lineage_Homo sapiens_hsa046401.48457776
27Shigellosis_Homo sapiens_hsa051311.46353470
28Chronic myeloid leukemia_Homo sapiens_hsa052201.44756073
29Acute myeloid leukemia_Homo sapiens_hsa052211.43915068
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.42371995
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42232346
32Legionellosis_Homo sapiens_hsa051341.38602200
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.38494805
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36460909
35Influenza A_Homo sapiens_hsa051641.36215108
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.31504733
37Apoptosis_Homo sapiens_hsa042101.28401031
38Pancreatic cancer_Homo sapiens_hsa052121.27830729
39Herpes simplex infection_Homo sapiens_hsa051681.24656142
40TNF signaling pathway_Homo sapiens_hsa046681.24489328
41Hepatitis B_Homo sapiens_hsa051611.24122820
42Malaria_Homo sapiens_hsa051441.22647027
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.17937460
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17711049
45Asthma_Homo sapiens_hsa053101.16871736
46Platelet activation_Homo sapiens_hsa046111.15781137
47Salmonella infection_Homo sapiens_hsa051321.14706879
48VEGF signaling pathway_Homo sapiens_hsa043701.11665405
49Viral myocarditis_Homo sapiens_hsa054161.05556722
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01399078
51Non-small cell lung cancer_Homo sapiens_hsa052230.96667577
52Graft-versus-host disease_Homo sapiens_hsa053320.96125524
53Notch signaling pathway_Homo sapiens_hsa043300.94717748
54Phagosome_Homo sapiens_hsa041450.87660718
55Colorectal cancer_Homo sapiens_hsa052100.87455074
56Hepatitis C_Homo sapiens_hsa051600.84304828
57Allograft rejection_Homo sapiens_hsa053300.81932660
58Prolactin signaling pathway_Homo sapiens_hsa049170.81844582
59* Endocytosis_Homo sapiens_hsa041440.79581347
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78756454
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78742921
62Caffeine metabolism_Homo sapiens_hsa002320.78489570
63mTOR signaling pathway_Homo sapiens_hsa041500.77407780
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75859245
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74464720
66Viral carcinogenesis_Homo sapiens_hsa052030.74445588
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73905074
68Epstein-Barr virus infection_Homo sapiens_hsa051690.73236478
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70914390
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70827675
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70722385
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70552946
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.70551348
74HTLV-I infection_Homo sapiens_hsa051660.68980828
75Type II diabetes mellitus_Homo sapiens_hsa049300.68777169
76Complement and coagulation cascades_Homo sapiens_hsa046100.68083546
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65125233
78Renal cell carcinoma_Homo sapiens_hsa052110.64236655
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63437251
80Small cell lung cancer_Homo sapiens_hsa052220.62705881
81GnRH signaling pathway_Homo sapiens_hsa049120.62238397
82Rheumatoid arthritis_Homo sapiens_hsa053230.61325716
83Prion diseases_Homo sapiens_hsa050200.60422616
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59683172
85Insulin resistance_Homo sapiens_hsa049310.59646160
86Amoebiasis_Homo sapiens_hsa051460.57383876
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.53637134
88Glioma_Homo sapiens_hsa052140.52503110
89HIF-1 signaling pathway_Homo sapiens_hsa040660.52118783
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51712246
91Inositol phosphate metabolism_Homo sapiens_hsa005620.50967177
92Proteoglycans in cancer_Homo sapiens_hsa052050.49204154
93Rap1 signaling pathway_Homo sapiens_hsa040150.48961643
94Lysine degradation_Homo sapiens_hsa003100.48284584
95Dorso-ventral axis formation_Homo sapiens_hsa043200.47505070
96FoxO signaling pathway_Homo sapiens_hsa040680.46947171
97Collecting duct acid secretion_Homo sapiens_hsa049660.46798486
98* MAPK signaling pathway_Homo sapiens_hsa040100.46597370
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46417493
100Endometrial cancer_Homo sapiens_hsa052130.45394737
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43682915
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.43640786
103MicroRNAs in cancer_Homo sapiens_hsa052060.43489964
104Estrogen signaling pathway_Homo sapiens_hsa049150.43059365
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42845096
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.42255432
107African trypanosomiasis_Homo sapiens_hsa051430.40783872
108Regulation of autophagy_Homo sapiens_hsa041400.40648237
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40149562
110Choline metabolism in cancer_Homo sapiens_hsa052310.37704974
111Bladder cancer_Homo sapiens_hsa052190.37555988
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36940383
113ErbB signaling pathway_Homo sapiens_hsa040120.34980536

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