ARPC3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)7.86506611
2gonadal mesoderm development (GO:0007506)6.83447930
3tyrosine phosphorylation of STAT protein (GO:0007260)5.20732945
4proteasome assembly (GO:0043248)4.59074465
5DNA deamination (GO:0045006)4.45444162
6ovulation cycle (GO:0042698)4.43930047
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.35144623
8ATP synthesis coupled proton transport (GO:0015986)4.35144623
9regulation of female gonad development (GO:2000194)4.08713313
10hepatocyte apoptotic process (GO:0097284)3.88333758
11telencephalon development (GO:0021537)3.77357093
12response to pheromone (GO:0019236)3.71987081
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66068481
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.65383602
15regulation of transmission of nerve impulse (GO:0051969)3.63104131
16GTP biosynthetic process (GO:0006183)3.61822354
17water-soluble vitamin biosynthetic process (GO:0042364)3.55962292
18I-kappaB kinase/NF-kappaB signaling (GO:0007249)3.54369846
19Arp2/3 complex-mediated actin nucleation (GO:0034314)3.54241194
20positive regulation of systemic arterial blood pressure (GO:0003084)3.49733494
21piRNA metabolic process (GO:0034587)3.37627136
22regulation of urine volume (GO:0035809)3.35978428
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29468681
24respiratory electron transport chain (GO:0022904)3.24222046
25ribonucleoprotein complex disassembly (GO:0032988)3.21979433
26termination of RNA polymerase III transcription (GO:0006386)3.21013057
27transcription elongation from RNA polymerase III promoter (GO:0006385)3.21013057
28electron transport chain (GO:0022900)3.20631874
29myoblast migration (GO:0051451)3.18134422
30regulation of cytokine production involved in inflammatory response (GO:1900015)3.14190146
31actin nucleation (GO:0045010)3.11407772
32negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.10734132
33positive regulation of prostaglandin secretion (GO:0032308)3.09682561
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.08996302
35regulation of interleukin-6 biosynthetic process (GO:0045408)3.06179320
36regulation of thymocyte apoptotic process (GO:0070243)3.02765817
37organelle disassembly (GO:1903008)3.01606016
38preassembly of GPI anchor in ER membrane (GO:0016254)2.99721829
39UTP biosynthetic process (GO:0006228)2.96354827
40amine catabolic process (GO:0009310)2.96136526
41cellular biogenic amine catabolic process (GO:0042402)2.96136526
42protein K11-linked deubiquitination (GO:0035871)2.92684877
43protein-cofactor linkage (GO:0018065)2.91164652
44positive regulation of T cell cytokine production (GO:0002726)2.88188831
45viral mRNA export from host cell nucleus (GO:0046784)2.87231367
46GPI anchor biosynthetic process (GO:0006506)2.82659389
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76781419
48regulation of bile acid biosynthetic process (GO:0070857)2.75775349
49C-terminal protein lipidation (GO:0006501)2.74519719
50rRNA modification (GO:0000154)2.70965502
51regulation of glycogen (starch) synthase activity (GO:2000465)2.70631358
52regulation of germinal center formation (GO:0002634)2.69649771
53phosphatidylinositol acyl-chain remodeling (GO:0036149)2.69568732
54negative regulation of multicellular organism growth (GO:0040015)2.69028337
55positive regulation of T-helper 1 type immune response (GO:0002827)2.68561963
56cytokine biosynthetic process (GO:0042089)2.68401478
57hydrogen ion transmembrane transport (GO:1902600)2.68259545
58purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.65920915
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.65855206
60hydrogen transport (GO:0006818)2.64288994
61purine nucleoside triphosphate biosynthetic process (GO:0009145)2.63332801
62cytidine deamination (GO:0009972)2.62913793
63cytidine metabolic process (GO:0046087)2.62913793
64cytidine catabolic process (GO:0006216)2.62913793
65negative regulation of thymocyte apoptotic process (GO:0070244)2.62585192
66proton transport (GO:0015992)2.61114008
67negative regulation of systemic arterial blood pressure (GO:0003085)2.60933743
68UTP metabolic process (GO:0046051)2.58386398
69regulation of prostaglandin secretion (GO:0032306)2.56980963
70antigen processing and presentation via MHC class Ib (GO:0002475)2.55121871
71tryptophan catabolic process (GO:0006569)2.54997336
72indole-containing compound catabolic process (GO:0042436)2.54997336
73indolalkylamine catabolic process (GO:0046218)2.54997336
74antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.53577883
75pyrimidine ribonucleoside catabolic process (GO:0046133)2.53228496
76respiratory chain complex IV assembly (GO:0008535)2.52716740
77GPI anchor metabolic process (GO:0006505)2.52462568
78vitamin biosynthetic process (GO:0009110)2.52012010
79energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.51386521
80ATP hydrolysis coupled proton transport (GO:0015991)2.51386521
81regulation of cellular amino acid metabolic process (GO:0006521)2.50263093
82behavioral response to nicotine (GO:0035095)2.50136191
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49826072
84kynurenine metabolic process (GO:0070189)2.49199848
85protein complex biogenesis (GO:0070271)2.48114751
86protein neddylation (GO:0045116)2.45964652
87positive regulation of T cell mediated cytotoxicity (GO:0001916)2.45788772
88regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.44780585
89neural tube formation (GO:0001841)2.44277240
90regulation of regulatory T cell differentiation (GO:0045589)2.42093791
91signal peptide processing (GO:0006465)2.41919048
92negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.41335309
93regulation of renal sodium excretion (GO:0035813)2.40626806
94cullin deneddylation (GO:0010388)2.40405960
95RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.38326491
96positive regulation of icosanoid secretion (GO:0032305)2.37108667
97positive regulation of antigen processing and presentation (GO:0002579)2.36443268
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.36336247
99ATP biosynthetic process (GO:0006754)2.35636250
100regulation of excretion (GO:0044062)2.34832876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.82091919
2VDR_22108803_ChIP-Seq_LS180_Human3.78414639
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35933629
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.01569316
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.73524258
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.70507763
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69940654
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64277845
9ELK1_19687146_ChIP-ChIP_HELA_Human2.42231229
10ZNF274_21170338_ChIP-Seq_K562_Hela2.40114851
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.36038971
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34270201
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29242629
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28802093
15VDR_23849224_ChIP-Seq_CD4+_Human2.23726454
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.21188938
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.15827995
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14205635
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.13213398
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05246755
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01442846
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94836377
23ER_23166858_ChIP-Seq_MCF-7_Human1.94774744
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85379459
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77326376
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.76580547
27FOXP3_21729870_ChIP-Seq_TREG_Human1.75916852
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75663926
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.72108734
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72050256
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70601718
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69035154
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65333160
34IRF1_19129219_ChIP-ChIP_H3396_Human1.51691013
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49880841
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46753394
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46473462
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45267274
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.44368502
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.42450409
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42231725
42GATA3_26560356_Chip-Seq_TH2_Human1.39033013
43TP53_22573176_ChIP-Seq_HFKS_Human1.34958234
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.34825416
45PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28309081
46MYC_19829295_ChIP-Seq_ESCs_Human1.27554085
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25495731
48GBX2_23144817_ChIP-Seq_PC3_Human1.25474761
49STAT1_20625510_ChIP-Seq_HELA_Human1.24519829
50FOXH1_21741376_ChIP-Seq_EPCs_Human1.24151573
51HTT_18923047_ChIP-ChIP_STHdh_Human1.22384003
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20383001
53CBP_20019798_ChIP-Seq_JUKART_Human1.20383001
54IGF1R_20145208_ChIP-Seq_DFB_Human1.16492583
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16117111
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.14988906
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14799578
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.14799578
59AR_20517297_ChIP-Seq_VCAP_Human1.14254146
60TAF15_26573619_Chip-Seq_HEK293_Human1.14145693
61EWS_26573619_Chip-Seq_HEK293_Human1.14117314
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13541133
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.13223348
64TAF2_19829295_ChIP-Seq_ESCs_Human1.13102212
65NCOR_22424771_ChIP-Seq_293T_Human1.12330629
66MYB_26560356_Chip-Seq_TH2_Human1.11088603
67ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10602010
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10320181
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10045287
70NANOG_19829295_ChIP-Seq_ESCs_Human1.08222490
71SOX2_19829295_ChIP-Seq_ESCs_Human1.08222490
72RUNX_20019798_ChIP-Seq_JUKART_Human1.07687429
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.07652559
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07384235
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07193795
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07078029
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05071732
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03677365
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03041132
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01998442
81ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98342592
82STAT3_18555785_Chip-Seq_ESCs_Mouse0.97618273
83POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96606828
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96522680
85ERG_20517297_ChIP-Seq_VCAP_Human0.95810441
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95480671
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95029982
88EZH2_22144423_ChIP-Seq_EOC_Human0.94459303
89FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91961069
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91650178
91FUS_26573619_Chip-Seq_HEK293_Human0.90356207
92FOXH1_21741376_ChIP-Seq_ESCs_Human0.90340085
93OCT4_18555785_Chip-Seq_ESCs_Mouse0.88901225
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88409599
95OCT4_20526341_ChIP-Seq_ESCs_Human0.88397725
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88159681
97DCP1A_22483619_ChIP-Seq_HELA_Human0.87877192
98NMYC_18555785_Chip-Seq_ESCs_Mouse0.86470784
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86359559
100GATA3_27048872_Chip-Seq_THYMUS_Human0.85563162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.46671849
2MP0002138_abnormal_hepatobiliary_system3.52490703
3MP0003787_abnormal_imprinting3.38107355
4MP0001835_abnormal_antigen_presentation3.22841529
5MP0005671_abnormal_response_to2.68357191
6MP0005646_abnormal_pituitary_gland2.64069458
7MP0008877_abnormal_DNA_methylation2.55806704
8MP0001790_abnormal_immune_system2.23844557
9MP0005387_immune_system_phenotype2.23844557
10MP0003252_abnormal_bile_duct2.19310592
11MP0004147_increased_porphyrin_level2.18445783
12MP0009785_altered_susceptibility_to2.14665198
13MP0003195_calcinosis2.10761989
14MP0002148_abnormal_hypersensitivity_rea2.06132091
15MP0005451_abnormal_body_composition2.05527885
16MP0005310_abnormal_salivary_gland2.04453074
17MP0002837_dystrophic_cardiac_calcinosis1.99414210
18MP0003763_abnormal_thymus_physiology1.93460685
19MP0005075_abnormal_melanosome_morpholog1.89183597
20MP0006072_abnormal_retinal_apoptosis1.89033169
21MP0008875_abnormal_xenobiotic_pharmacok1.86787156
22MP0001800_abnormal_humoral_immune1.86444496
23MP0005187_abnormal_penis_morphology1.85587067
24MP0000372_irregular_coat_pigmentation1.77790691
25MP0002166_altered_tumor_susceptibility1.75791055
26MP0009764_decreased_sensitivity_to1.74487420
27MP0003724_increased_susceptibility_to1.68221851
28MP0005167_abnormal_blood-brain_barrier1.57944904
29MP0003646_muscle_fatigue1.54642615
30MP0002452_abnormal_antigen_presenting1.53505481
31MP0002254_reproductive_system_inflammat1.49279345
32MP0002723_abnormal_immune_serum1.47997307
33MP0009333_abnormal_splenocyte_physiolog1.47882258
34MP0005084_abnormal_gallbladder_morpholo1.43788489
35MP0004215_abnormal_myocardial_fiber1.43565747
36MP0000685_abnormal_immune_system1.42905764
37MP0006036_abnormal_mitochondrial_physio1.41091697
38MP0003315_abnormal_perineum_morphology1.39819359
39MP0010155_abnormal_intestine_physiology1.36014503
40MP0004145_abnormal_muscle_electrophysio1.35684804
41MP0005379_endocrine/exocrine_gland_phen1.35476472
42MP0002009_preneoplasia1.35097199
43MP0004142_abnormal_muscle_tone1.34588141
44MP0005083_abnormal_biliary_tract1.30432026
45MP0002006_tumorigenesis1.30400255
46MP0001968_abnormal_touch/_nociception1.29350967
47MP0003121_genomic_imprinting1.29347722
48MP0002933_joint_inflammation1.28743647
49MP0001765_abnormal_ion_homeostasis1.28118305
50MP0001819_abnormal_immune_cell1.26147199
51MP0001873_stomach_inflammation1.22513934
52MP0005000_abnormal_immune_tolerance1.21545212
53MP0002405_respiratory_system_inflammati1.21381613
54MP0001756_abnormal_urination1.21236125
55MP0002420_abnormal_adaptive_immunity1.20974953
56MP0005645_abnormal_hypothalamus_physiol1.19530539
57MP0005636_abnormal_mineral_homeostasis1.17870014
58MP0005253_abnormal_eye_physiology1.15696708
59MP0002736_abnormal_nociception_after1.14771269
60MP0002139_abnormal_hepatobiliary_system1.13516861
61MP0009046_muscle_twitch1.11654984
62MP0010386_abnormal_urinary_bladder1.08995464
63MP0000613_abnormal_salivary_gland1.08897898
64MP0005025_abnormal_response_to1.07241693
65MP0002928_abnormal_bile_duct1.04099258
66MP0001845_abnormal_inflammatory_respons1.01799106
67MP0003866_abnormal_defecation1.01048813
68MP0002163_abnormal_gland_morphology1.00809855
69MP0003880_abnormal_central_pattern0.99090508
70MP0002332_abnormal_exercise_endurance0.98285435
71MP0001727_abnormal_embryo_implantation0.96135563
72MP0009765_abnormal_xenobiotic_induced0.94664725
73MP0005423_abnormal_somatic_nervous0.93940351
74MP0001984_abnormal_olfaction0.93222413
75MP0008469_abnormal_protein_level0.91129724
76MP0005551_abnormal_eye_electrophysiolog0.89819562
77MP0004484_altered_response_of0.89815807
78MP0006054_spinal_hemorrhage0.88964492
79MP0005266_abnormal_metabolism0.88256043
80MP0003436_decreased_susceptibility_to0.87180248
81MP0000716_abnormal_immune_system0.83617233
82MP0004036_abnormal_muscle_relaxation0.83265216
83MP0008775_abnormal_heart_ventricle0.80968155
84MP0005410_abnormal_fertilization0.79749046
85MP0009384_cardiac_valve_regurgitation0.78976193
86MP0005408_hypopigmentation0.77330473
87MP0009763_increased_sensitivity_to0.76303831
88MP0000689_abnormal_spleen_morphology0.75818411
89MP0002272_abnormal_nervous_system0.74416030
90MP0004084_abnormal_cardiac_muscle0.74143175
91MP0005365_abnormal_bile_salt0.73655764
92MP0001970_abnormal_pain_threshold0.72909462
93MP0002419_abnormal_innate_immunity0.71644682
94MP0002693_abnormal_pancreas_physiology0.70798033
95MP0002429_abnormal_blood_cell0.70785300
96MP0002398_abnormal_bone_marrow0.70526104
97MP0002733_abnormal_thermal_nociception0.69845035
98MP0001986_abnormal_taste_sensitivity0.69627540
99MP0003718_maternal_effect0.68469828
100MP0003045_fibrosis0.68443558

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)6.56793165
2Abnormal drinking behavior (HP:0030082)6.13990949
3Polydipsia (HP:0001959)6.13990949
4Polyuria (HP:0000103)4.21214985
5Elevated erythrocyte sedimentation rate (HP:0003565)3.85617355
6Abnormality of renin-angiotensin system (HP:0000847)3.65894326
7Abnormal urine output (HP:0012590)3.44494190
8Mitochondrial inheritance (HP:0001427)3.34203452
9Stomatitis (HP:0010280)3.22641328
10Increased CSF lactate (HP:0002490)3.13818204
11Pancreatic cysts (HP:0001737)3.08519706
12Abnormality of renal excretion (HP:0011036)3.06586619
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.06178871
14Acute necrotizing encephalopathy (HP:0006965)3.04352309
15Chronic diarrhea (HP:0002028)3.01744380
16Increased hepatocellular lipid droplets (HP:0006565)2.98349303
17Renal Fanconi syndrome (HP:0001994)2.97404508
18Lipid accumulation in hepatocytes (HP:0006561)2.96374589
19Hepatocellular necrosis (HP:0001404)2.95399139
20Nephronophthisis (HP:0000090)2.92544230
21Menstrual irregularities (HP:0000858)2.88825586
22Abolished electroretinogram (ERG) (HP:0000550)2.73518181
23Hepatic necrosis (HP:0002605)2.67668881
24Congenital, generalized hypertrichosis (HP:0004540)2.64714735
25Abnormal mitochondria in muscle tissue (HP:0008316)2.60294984
26Abnormality of the renal medulla (HP:0100957)2.60112516
27IgG deficiency (HP:0004315)2.55974844
28Abnormality of the renal cortex (HP:0011035)2.52536669
29Abnormal biliary tract physiology (HP:0012439)2.50351302
30Bile duct proliferation (HP:0001408)2.50351302
31Hypoproteinemia (HP:0003075)2.45441908
32Molar tooth sign on MRI (HP:0002419)2.42636407
33Abnormality of midbrain morphology (HP:0002418)2.42636407
34Progressive macrocephaly (HP:0004481)2.40213029
35Respiratory difficulties (HP:0002880)2.39875885
36Pancreatic fibrosis (HP:0100732)2.38276192
37Hemoptysis (HP:0002105)2.32731642
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30703031
39Type I transferrin isoform profile (HP:0003642)2.29887220
40Acute encephalopathy (HP:0006846)2.28605124
41Exertional dyspnea (HP:0002875)2.28313801
42Aplasia/Hypoplasia of the spleen (HP:0010451)2.27726725
43Optic disc pallor (HP:0000543)2.27243323
44Asplenia (HP:0001746)2.25856261
45Abnormality of urine glucose concentration (HP:0011016)2.16613325
46Glycosuria (HP:0003076)2.16613325
47Chronic mucocutaneous candidiasis (HP:0002728)2.15123925
48Recurrent cutaneous fungal infections (HP:0011370)2.15123925
49Hyponatremia (HP:0002902)2.14093840
50Adrenal hypoplasia (HP:0000835)2.13803873
51Attenuation of retinal blood vessels (HP:0007843)2.11980550
52Renal cortical cysts (HP:0000803)2.08472118
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06999417
54Porencephaly (HP:0002132)1.95615125
55Cerebral palsy (HP:0100021)1.95010366
56Agitation (HP:0000713)1.94687279
57Vacuolated lymphocytes (HP:0001922)1.94192400
58Generalized aminoaciduria (HP:0002909)1.92947880
59Increased intramyocellular lipid droplets (HP:0012240)1.90487571
60Chronic obstructive pulmonary disease (HP:0006510)1.87900268
61Obstructive lung disease (HP:0006536)1.87900268
62Reduced subcutaneous adipose tissue (HP:0003758)1.87662302
63Chronic hepatic failure (HP:0100626)1.87538478
64True hermaphroditism (HP:0010459)1.86317810
65Autoimmune hemolytic anemia (HP:0001890)1.84459675
66Increased serum lactate (HP:0002151)1.83971277
67Abnormality of renal resorption (HP:0011038)1.83068592
68Tubular atrophy (HP:0000092)1.82836679
69Type 2 muscle fiber atrophy (HP:0003554)1.81693279
70Limb dystonia (HP:0002451)1.76686577
71Anhidrosis (HP:0000970)1.76488673
72Methylmalonic acidemia (HP:0002912)1.75979003
73Increased IgM level (HP:0003496)1.75851520
74Myotonia (HP:0002486)1.75258483
75Neonatal onset (HP:0003623)1.74274892
76Tongue fasciculations (HP:0001308)1.72877031
77Leukodystrophy (HP:0002415)1.71236854
78Cerebral edema (HP:0002181)1.70864645
79Aplastic anemia (HP:0001915)1.70768489
80IgM deficiency (HP:0002850)1.69717543
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.69534367
82Decreased activity of mitochondrial respiratory chain (HP:0008972)1.69534367
83Vasculitis (HP:0002633)1.68837229
843-Methylglutaconic aciduria (HP:0003535)1.68415530
85Abnormal protein glycosylation (HP:0012346)1.67922275
86Abnormal glycosylation (HP:0012345)1.67922275
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.67922275
88Abnormal protein N-linked glycosylation (HP:0012347)1.67922275
89Congenital hepatic fibrosis (HP:0002612)1.67457935
90Tinnitus (HP:0000360)1.67183662
91Respiratory failure (HP:0002878)1.66560757
92Multiple enchondromatosis (HP:0005701)1.66169341
93Abnormality of the pleura (HP:0002103)1.66075101
94Pendular nystagmus (HP:0012043)1.65581749
95Severe visual impairment (HP:0001141)1.65460083
96Methylmalonic aciduria (HP:0012120)1.64679069
97Constricted visual fields (HP:0001133)1.64340481
98Dry hair (HP:0011359)1.64142956
99Enlarged epiphyses (HP:0010580)1.64040805
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.63984930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.86437763
2TXK3.61124215
3MYLK3.09868869
4BLK2.88814850
5WNK42.77690571
6GRK72.45146250
7NUAK12.42675263
8TSSK62.21168598
9EIF2AK32.14642104
10MAP3K132.12635035
11ITK2.11844947
12ADRBK22.03322132
13TEC1.67906719
14FRK1.63374478
15NEK11.58202727
16STK391.51966485
17STK161.49527255
18OXSR11.44715827
19IKBKB1.41226221
20STK38L1.40616130
21CCNB11.36046979
22PTK61.35218318
23SYK1.22572636
24MOS1.18794725
25CAMKK21.17536113
26BTK1.16931502
27LYN1.16906981
28TNK21.14719582
29TAOK31.10074105
30TGFBR21.07576763
31LIMK11.03984308
32EIF2AK11.03201324
33INSRR1.01671097
34TIE11.01544085
35MAP3K140.97904571
36TLK10.97868499
37GRK50.97351723
38MAP4K10.97205752
39PLK20.96381312
40GRK10.94455918
41FES0.93377030
42PDK20.92998912
43WNK10.92994488
44WNK30.92741329
45PRKCQ0.91030087
46IRAK10.87469186
47EIF2AK20.84021714
48PRKCH0.83961720
49KIT0.82068308
50PTK2B0.81334788
51ILK0.79975003
52RPS6KA50.79876335
53TAOK10.77652638
54STK240.76861911
55PRKCE0.76170933
56CSK0.73410719
57CDK30.72051841
58NME20.67092485
59PHKG20.65060072
60PHKG10.65060072
61MAP2K60.64936561
62EPHB20.64573981
63LCK0.64561213
64VRK20.64422006
65PRKCG0.63638160
66ADRBK10.63513042
67PIK3CA0.62916848
68PRKACA0.62013779
69CSF1R0.61868837
70JAK30.61117888
71DAPK10.60752322
72KDR0.60513887
73LMTK20.58771431
74FGR0.57028629
75OBSCN0.56189609
76ROCK10.55622054
77PLK40.54871763
78DMPK0.53409762
79NLK0.52788894
80CSNK1G10.51685461
81PRKG10.50842137
82CHUK0.50642597
83MAP3K90.49957148
84PAK30.48143752
85IKBKE0.47874296
86BCKDK0.47852943
87CSNK1G20.47737080
88CLK10.46654577
89TYK20.46482369
90STK100.46471011
91PRKCA0.44276143
92PRKACG0.42927069
93MATK0.42619647
94CSNK1G30.42354159
95TNIK0.41782295
96SGK10.41602305
97MAP3K70.40923960
98CSNK2A20.38912146
99DYRK20.38255604
100PIK3CG0.38203102

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.50995044
2Oxidative phosphorylation_Homo sapiens_hsa001903.35063647
3Protein export_Homo sapiens_hsa030603.14195518
4Asthma_Homo sapiens_hsa053102.88602133
5Allograft rejection_Homo sapiens_hsa053302.82291819
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.78010668
7Autoimmune thyroid disease_Homo sapiens_hsa053202.72750969
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.69429979
9Parkinsons disease_Homo sapiens_hsa050122.62013868
10Graft-versus-host disease_Homo sapiens_hsa053322.53678335
11Type I diabetes mellitus_Homo sapiens_hsa049402.45651442
12RNA polymerase_Homo sapiens_hsa030202.33129638
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17481261
14Caffeine metabolism_Homo sapiens_hsa002322.11054955
15Rheumatoid arthritis_Homo sapiens_hsa053232.02978923
16Linoleic acid metabolism_Homo sapiens_hsa005911.95161808
17Ribosome_Homo sapiens_hsa030101.94808088
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90517425
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86661120
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83467759
21Alzheimers disease_Homo sapiens_hsa050101.80480398
22Cardiac muscle contraction_Homo sapiens_hsa042601.75586362
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.74554748
24Collecting duct acid secretion_Homo sapiens_hsa049661.73262927
25Huntingtons disease_Homo sapiens_hsa050161.64477618
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49235221
27Viral myocarditis_Homo sapiens_hsa054161.44647036
28Ether lipid metabolism_Homo sapiens_hsa005651.42507915
29Antigen processing and presentation_Homo sapiens_hsa046121.33582626
30Primary immunodeficiency_Homo sapiens_hsa053401.31777867
31Basal transcription factors_Homo sapiens_hsa030221.23165956
32Sulfur metabolism_Homo sapiens_hsa009201.21120878
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19760439
34Staphylococcus aureus infection_Homo sapiens_hsa051501.17063186
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12749252
36Arachidonic acid metabolism_Homo sapiens_hsa005901.04483128
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.02995021
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95927625
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90646520
40Hematopoietic cell lineage_Homo sapiens_hsa046400.88290535
41Pyrimidine metabolism_Homo sapiens_hsa002400.88033970
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85379112
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83549166
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83426994
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.83174438
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82764978
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81012837
48Regulation of autophagy_Homo sapiens_hsa041400.79168571
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76640302
50Phototransduction_Homo sapiens_hsa047440.75616437
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75327276
52Ovarian steroidogenesis_Homo sapiens_hsa049130.74529473
53Leishmaniasis_Homo sapiens_hsa051400.73578764
54RNA transport_Homo sapiens_hsa030130.71504470
55RNA degradation_Homo sapiens_hsa030180.70676890
56Purine metabolism_Homo sapiens_hsa002300.70481579
57Phagosome_Homo sapiens_hsa041450.68370689
58Fatty acid elongation_Homo sapiens_hsa000620.66936034
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64429335
60Propanoate metabolism_Homo sapiens_hsa006400.61015232
61Systemic lupus erythematosus_Homo sapiens_hsa053220.59994513
62Epstein-Barr virus infection_Homo sapiens_hsa051690.57310481
63Dorso-ventral axis formation_Homo sapiens_hsa043200.55174405
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52651397
65Butanoate metabolism_Homo sapiens_hsa006500.51704313
66Tryptophan metabolism_Homo sapiens_hsa003800.50459439
67Chemical carcinogenesis_Homo sapiens_hsa052040.48940997
68Morphine addiction_Homo sapiens_hsa050320.48573006
69Toxoplasmosis_Homo sapiens_hsa051450.47497828
70Measles_Homo sapiens_hsa051620.46755737
71Mineral absorption_Homo sapiens_hsa049780.46538127
72Homologous recombination_Homo sapiens_hsa034400.44743020
73Vibrio cholerae infection_Homo sapiens_hsa051100.44689293
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.43368789
75Tuberculosis_Homo sapiens_hsa051520.42266600
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42061222
77Legionellosis_Homo sapiens_hsa051340.40688616
78Peroxisome_Homo sapiens_hsa041460.39613095
79Salivary secretion_Homo sapiens_hsa049700.38930498
80Herpes simplex infection_Homo sapiens_hsa051680.38817014
81Pancreatic secretion_Homo sapiens_hsa049720.38255607
82Metabolic pathways_Homo sapiens_hsa011000.38239267
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.37054755
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36811983
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33001490
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32676465
87Platelet activation_Homo sapiens_hsa046110.31250417
88GABAergic synapse_Homo sapiens_hsa047270.31193737
89Retinol metabolism_Homo sapiens_hsa008300.30761878
90T cell receptor signaling pathway_Homo sapiens_hsa046600.30369312
91Pertussis_Homo sapiens_hsa051330.28211808
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26283318
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25754546
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25186805
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22977731
96Lysosome_Homo sapiens_hsa041420.22361300
97Shigellosis_Homo sapiens_hsa051310.21677847
98ABC transporters_Homo sapiens_hsa020100.21140395
99Insulin secretion_Homo sapiens_hsa049110.20684655
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.19789265

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