ARPC1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.78736454
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.78736454
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.60152845
4negative regulation of cell killing (GO:0031342)4.60152845
5antigen processing and presentation of endogenous antigen (GO:0019883)4.46141538
6leukocyte aggregation (GO:0070486)4.37904076
7neutrophil activation involved in immune response (GO:0002283)4.28108122
8positive regulation of gamma-delta T cell activation (GO:0046645)4.00892297
9leukocyte migration involved in inflammatory response (GO:0002523)3.77691196
10respiratory burst (GO:0045730)3.73958889
11detection of other organism (GO:0098543)3.71909538
12detection of bacterium (GO:0016045)3.71442569
13regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.61785085
14regulation of B cell receptor signaling pathway (GO:0050855)3.56334738
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.44748739
16regulation of mast cell degranulation (GO:0043304)3.41477607
17pentose-phosphate shunt (GO:0006098)3.36899333
18response to peptidoglycan (GO:0032494)3.34644929
19viral transcription (GO:0019083)3.32845090
20positive regulation by organism of defense response of other organism involved in symbiotic interact3.32070271
21modulation by symbiont of host immune response (GO:0052553)3.32070271
22positive regulation by symbiont of host defense response (GO:0052509)3.32070271
23modulation by symbiont of host defense response (GO:0052031)3.32070271
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.32070271
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.32070271
26positive regulation of B cell differentiation (GO:0045579)3.31699284
27positive thymic T cell selection (GO:0045059)3.30433556
28* Arp2/3 complex-mediated actin nucleation (GO:0034314)3.29170564
29immunoglobulin mediated immune response (GO:0016064)3.25322054
30NADPH regeneration (GO:0006740)3.24249686
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.24215031
32translational termination (GO:0006415)3.14943973
33cellular response to type I interferon (GO:0071357)3.13834168
34type I interferon signaling pathway (GO:0060337)3.13834168
35negative regulation of phagocytosis (GO:0050765)3.11700392
36cellular extravasation (GO:0045123)3.11415263
37response to type I interferon (GO:0034340)3.11347191
38regulation of mast cell activation involved in immune response (GO:0033006)3.08334179
39positive regulation of mast cell activation (GO:0033005)3.06872168
40regulation of B cell differentiation (GO:0045577)3.05773237
41pinocytosis (GO:0006907)3.05438768
42negative T cell selection (GO:0043383)3.05171222
43interferon-gamma-mediated signaling pathway (GO:0060333)3.04100472
44negative thymic T cell selection (GO:0045060)3.04012207
45lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03430422
46B cell receptor signaling pathway (GO:0050853)3.01603607
47regulation of myeloid leukocyte mediated immunity (GO:0002886)3.01113797
48detection of external biotic stimulus (GO:0098581)3.00643634
49regulation of leukocyte degranulation (GO:0043300)3.00207006
50regulation of T cell tolerance induction (GO:0002664)2.97989594
51response to muramyl dipeptide (GO:0032495)2.97827421
52regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94972153
53regulation of natural killer cell mediated immunity (GO:0002715)2.94972153
54neutrophil activation (GO:0042119)2.90139474
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.89757327
56regulation of mast cell activation (GO:0033003)2.89427464
57B cell mediated immunity (GO:0019724)2.88898843
58membrane raft organization (GO:0031579)2.88308181
59regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87954503
60response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.85692069
61response to host immune response (GO:0052572)2.85692069
62positive regulation of antigen processing and presentation (GO:0002579)2.85174912
63negative regulation of leukocyte mediated immunity (GO:0002704)2.83891960
64regulation of T cell mediated cytotoxicity (GO:0001914)2.81280877
65positive regulation of T cell mediated cytotoxicity (GO:0001916)2.81066239
66regulation of gamma-delta T cell differentiation (GO:0045586)2.79909429
67SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79895027
68protein targeting to ER (GO:0045047)2.79116665
69ribosomal small subunit biogenesis (GO:0042274)2.78791886
70cotranslational protein targeting to membrane (GO:0006613)2.78707316
71regulation of interferon-beta biosynthetic process (GO:0045357)2.78274111
72adhesion of symbiont to host cell (GO:0044650)2.78257510
73virion attachment to host cell (GO:0019062)2.78257510
74regulation of antigen processing and presentation (GO:0002577)2.77468174
75myeloid dendritic cell activation (GO:0001773)2.77056605
76negative regulation of lymphocyte mediated immunity (GO:0002707)2.76262733
77regulation of alpha-beta T cell proliferation (GO:0046640)2.75911353
78defense response to protozoan (GO:0042832)2.75332713
79activated T cell proliferation (GO:0050798)2.74348570
80T cell selection (GO:0045058)2.73793030
81amyloid precursor protein catabolic process (GO:0042987)2.73646251
82thymic T cell selection (GO:0045061)2.73374591
83regulation of tolerance induction (GO:0002643)2.72063078
84cytidine metabolic process (GO:0046087)2.71617614
85cytidine catabolic process (GO:0006216)2.71617614
86cytidine deamination (GO:0009972)2.71617614
87ribosomal small subunit assembly (GO:0000028)2.71530711
88granulocyte activation (GO:0036230)2.70277292
89establishment of protein localization to endoplasmic reticulum (GO:0072599)2.69812477
90* actin nucleation (GO:0045010)2.69167175
91negative regulation of innate immune response (GO:0045824)2.69087119
92angiogenesis involved in wound healing (GO:0060055)2.67759009
93leukocyte cell-cell adhesion (GO:0007159)2.67479076
94myeloid cell homeostasis (GO:0002262)2.66658340
95positive regulation of mast cell degranulation (GO:0043306)2.66053210
96positive regulation of mast cell activation involved in immune response (GO:0033008)2.66053210
97response to interleukin-15 (GO:0070672)2.65444225
98positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65259380
99heterotypic cell-cell adhesion (GO:0034113)2.64690275
100response to host (GO:0075136)2.64353483
101response to host defenses (GO:0052200)2.64353483
102response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64353483
103response to fungus (GO:0009620)2.63541093
104myeloid dendritic cell differentiation (GO:0043011)2.63378019
105positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62756207
106protein localization to endoplasmic reticulum (GO:0070972)2.62270704
107T cell costimulation (GO:0031295)2.61141945
108positive T cell selection (GO:0043368)2.61047978
109regulation of gamma-delta T cell activation (GO:0046643)2.61011353
110detection of biotic stimulus (GO:0009595)2.60793271
111NIK/NF-kappaB signaling (GO:0038061)2.60373640
112myeloid cell activation involved in immune response (GO:0002275)2.60059578
113tolerance induction (GO:0002507)2.59952301
114regulation of interleukin-2 biosynthetic process (GO:0045076)2.59445337
115viral life cycle (GO:0019058)2.58962837
116lymphocyte chemotaxis (GO:0048247)2.57915270
117translational elongation (GO:0006414)2.55957540
118macrophage differentiation (GO:0030225)2.55049454
119mannose metabolic process (GO:0006013)2.54650176
120negative regulation of erythrocyte differentiation (GO:0045647)2.54631192
121barbed-end actin filament capping (GO:0051016)2.53486159
122cortical actin cytoskeleton organization (GO:0030866)2.53448602
123response to laminar fluid shear stress (GO:0034616)2.52966028
124positive regulation of macrophage differentiation (GO:0045651)2.51021569
125mature B cell differentiation involved in immune response (GO:0002313)2.50648914
126positive regulation of interleukin-17 production (GO:0032740)2.49149879
127negative regulation of interleukin-12 production (GO:0032695)2.47746366
128positive regulation of lamellipodium assembly (GO:0010592)2.47499028
129leukocyte degranulation (GO:0043299)2.47342434
130antigen processing and presentation via MHC class Ib (GO:0002475)2.46652153
131negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.46264213
132amyloid precursor protein metabolic process (GO:0042982)2.45667220
133mast cell activation (GO:0045576)2.45240295
134T cell homeostasis (GO:0043029)2.45096361
135regulation of protein heterodimerization activity (GO:0043497)2.43954952
136adhesion of symbiont to host (GO:0044406)2.43243976
137mature B cell differentiation (GO:0002335)2.43033164
138neutrophil mediated immunity (GO:0002446)2.41852092
139T cell migration (GO:0072678)2.40410348
140positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.38240184
141cellular protein complex disassembly (GO:0043624)2.37036876
142regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.35815264
143positive regulation of natural killer cell differentiation (GO:0032825)2.34918010
144positive regulation of interferon-alpha production (GO:0032727)2.31472547
145nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.30672264
146response to interferon-beta (GO:0035456)2.29990859
147positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.28993681
148regulation of necroptotic process (GO:0060544)2.28968995
149T cell proliferation (GO:0042098)2.28029400
150macrophage activation involved in immune response (GO:0002281)2.28023923
151lymphocyte apoptotic process (GO:0070227)2.26106263
152cortical cytoskeleton organization (GO:0030865)2.25647660
153response to protozoan (GO:0001562)2.25568777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse3.66370337
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.52415665
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.35714385
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35105773
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21249437
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.07016720
7MYB_21317192_ChIP-Seq_ERMYB_Mouse2.81346277
8E2F7_22180533_ChIP-Seq_HELA_Human2.76869764
9* VDR_21846776_ChIP-Seq_THP-1_Human2.72837716
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.72759455
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.55665236
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55216226
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52918350
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51706440
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34863074
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.33640285
17* SPI1_23547873_ChIP-Seq_NB4_Human2.32365699
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28182923
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26508942
20SCL_19346495_ChIP-Seq_HPC-7_Human2.25169355
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21335497
22* VDR_24763502_ChIP-Seq_THP-1_Human2.21050184
23* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14960037
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.12903561
25MAF_26560356_Chip-Seq_TH1_Human2.05327887
26* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04296029
27* MYB_26560356_Chip-Seq_TH2_Human1.96673619
28* RUNX1_22412390_ChIP-Seq_EML_Mouse1.92131840
29* MYC_22102868_ChIP-Seq_BL_Human1.89820441
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82523434
31LXR_22292898_ChIP-Seq_THP-1_Human1.82383277
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81636615
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77701593
34UTX_26944678_Chip-Seq_JUKART_Human1.75823656
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75672549
36* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75103423
37* ELK3_25401928_ChIP-Seq_HUVEC_Human1.74060486
38* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73046129
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.69413522
40RUNX_20019798_ChIP-Seq_JUKART_Human1.69323167
41MYB_26560356_Chip-Seq_TH1_Human1.63874091
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63188079
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61541560
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58669735
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57902546
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57233750
47* SPI1_23127762_ChIP-Seq_K562_Human1.55609317
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52544793
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47502700
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.45166081
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43634006
52MAF_26560356_Chip-Seq_TH2_Human1.43453396
53BCL6_27268052_Chip-Seq_Bcells_Human1.43414120
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41168555
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40605286
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39824359
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37595494
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37595258
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.33150084
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32327668
61BCOR_27268052_Chip-Seq_Bcells_Human1.32033301
62* TCF7_22412390_ChIP-Seq_EML_Mouse1.31200411
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29277796
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28317930
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.26365685
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.26278189
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25611039
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24816220
69PU_27001747_Chip-Seq_BMDM_Mouse1.23994288
70GATA1_19941826_ChIP-Seq_K562_Human1.23778952
71TFEB_21752829_ChIP-Seq_HELA_Human1.22839359
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20624090
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20522857
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20021554
75* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19882071
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18688185
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18350795
78NCOR1_26117541_ChIP-Seq_K562_Human1.16081104
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15856053
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14910623
81GATA3_27048872_Chip-Seq_THYMUS_Human1.14363047
82* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12785503
83* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12655267
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12127460
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12085307
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11469233
87FOXM1_23109430_ChIP-Seq_U2OS_Human1.11438829
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11287049
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09956817
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09753416
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09369471
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08803473
93MYC_18555785_ChIP-Seq_MESCs_Mouse1.08264656
94KDM2B_26808549_Chip-Seq_DND41_Human1.07713871
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07358807
96CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06583423
97VDR_24787735_ChIP-Seq_THP-1_Human1.06505472
98RACK7_27058665_Chip-Seq_MCF-7_Human1.05524272
99P68_20966046_ChIP-Seq_HELA_Human1.03441917
100VDR_23849224_ChIP-Seq_CD4+_Human1.02616709
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00214193
102ETS1_20019798_ChIP-Seq_JURKAT_Human0.99990666
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99881607
104EST1_17652178_ChIP-ChIP_JURKAT_Human0.99759739
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99203942
106SPI1_20517297_ChIP-Seq_HL60_Human0.98185607
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98028301
108XRN2_22483619_ChIP-Seq_HELA_Human0.97994900
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97855354
110GATA3_26560356_Chip-Seq_TH2_Human0.97512890
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96751480
112SA1_27219007_Chip-Seq_ERYTHROID_Human0.96721002
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96376198
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.95902526
115TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94432527
116MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94202144
117GATA1_22025678_ChIP-Seq_K562_Human0.93521544
118* CTCF_26484167_Chip-Seq_Bcells_Mouse0.93424512
119* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92443269
120TET1_21451524_ChIP-Seq_MESCs_Mouse0.91422223
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91342452
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91237721
123ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90476427
124ELK1_19687146_ChIP-ChIP_HELA_Human0.90033824
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88457892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.08142414
2MP0001835_abnormal_antigen_presentation2.91989045
3MP0003436_decreased_susceptibility_to2.85385774
4MP0005058_abnormal_lysosome_morphology2.74928881
5MP0000685_abnormal_immune_system2.62373703
6MP0009785_altered_susceptibility_to2.59563760
7MP0008438_abnormal_cutaneous_collagen2.58079834
8MP0005000_abnormal_immune_tolerance2.55819642
9MP0002419_abnormal_innate_immunity2.55612687
10MP0005025_abnormal_response_to2.43059060
11MP0005387_immune_system_phenotype2.39162515
12MP0001790_abnormal_immune_system2.39162515
13MP0001800_abnormal_humoral_immune2.35882904
14MP0002452_abnormal_antigen_presenting2.35273512
15MP0002148_abnormal_hypersensitivity_rea2.21090252
16MP0002420_abnormal_adaptive_immunity2.20403987
17MP0009333_abnormal_splenocyte_physiolog2.19856940
18MP0002723_abnormal_immune_serum2.19388057
19MP0001819_abnormal_immune_cell2.18171301
20MP0005671_abnormal_response_to2.11341680
21MP0003724_increased_susceptibility_to2.09200673
22MP0000465_gastrointestinal_hemorrhage2.08688840
23MP0006082_CNS_inflammation2.08629575
24MP0003300_gastrointestinal_ulcer2.07519079
25MP0005464_abnormal_platelet_physiology2.00185715
26MP0002396_abnormal_hematopoietic_system1.99969270
27MP0002405_respiratory_system_inflammati1.91840407
28MP0003806_abnormal_nucleotide_metabolis1.85322649
29MP0009278_abnormal_bone_marrow1.82735136
30MP0002933_joint_inflammation1.82056816
31MP0001533_abnormal_skeleton_physiology1.81186016
32MP0002398_abnormal_bone_marrow1.80134189
33MP0000920_abnormal_myelination1.79750006
34MP0000716_abnormal_immune_system1.76772439
35MP0004947_skin_inflammation1.76332555
36MP0003763_abnormal_thymus_physiology1.68614033
37MP0000689_abnormal_spleen_morphology1.66551792
38MP0010155_abnormal_intestine_physiology1.59895764
39MP0002722_abnormal_immune_system1.57012563
40MP0001851_eye_inflammation1.56338329
41MP0003075_altered_response_to1.54150695
42MP0002166_altered_tumor_susceptibility1.53642896
43MP0002429_abnormal_blood_cell1.53177258
44MP0001845_abnormal_inflammatory_respons1.50464916
45MP0009840_abnormal_foam_cell1.49414849
46MP0005397_hematopoietic_system_phenotyp1.48151364
47MP0001545_abnormal_hematopoietic_system1.48151364
48MP0003448_altered_tumor_morphology1.46357534
49MP0004808_abnormal_hematopoietic_stem1.46321003
50MP0001853_heart_inflammation1.45894318
51MP0003566_abnormal_cell_adhesion1.43923339
52MP0005023_abnormal_wound_healing1.42794095
53MP0000858_altered_metastatic_potential1.41350412
54MP0003172_abnormal_lysosome_physiology1.40022755
55MP0000343_altered_response_to1.39871033
56MP0001873_stomach_inflammation1.35910526
57MP0001958_emphysema1.35108230
58MP0003866_abnormal_defecation1.29893489
59MP0000490_abnormal_crypts_of1.27274710
60MP0004510_myositis1.24947927
61MP0008004_abnormal_stomach_pH1.22714232
62MP0010352_gastrointestinal_tract_polyps1.17951590
63MP0005310_abnormal_salivary_gland1.16088564
64MP0002877_abnormal_melanocyte_morpholog1.15152564
65MP0008469_abnormal_protein_level1.14121988
66MP0003950_abnormal_plasma_membrane1.14073382
67MP0002132_abnormal_respiratory_system1.10946216
68MP0005166_decreased_susceptibility_to1.10851470
69MP0000703_abnormal_thymus_morphology1.10493671
70MP0002006_tumorigenesis1.09341900
71MP0003279_aneurysm1.07057761
72MP0003191_abnormal_cellular_cholesterol1.06985993
73MP0010307_abnormal_tumor_latency1.06088321
74MP0005174_abnormal_tail_pigmentation1.05375123
75MP0006054_spinal_hemorrhage1.04543356
76MP0003453_abnormal_keratinocyte_physiol1.03530851
77MP0003091_abnormal_cell_migration1.03322647
78MP0002998_abnormal_bone_remodeling1.01088658
79MP0004185_abnormal_adipocyte_glucose0.96652167
80MP0000604_amyloidosis0.96627200
81MP0003690_abnormal_glial_cell0.95364082
82MP0005390_skeleton_phenotype0.94823434
83MP0001243_abnormal_dermal_layer0.91016561
84MP0000015_abnormal_ear_pigmentation0.89494090
85MP0000383_abnormal_hair_follicle0.88301617
86MP0003705_abnormal_hypodermis_morpholog0.87538464
87MP0003828_pulmonary_edema0.86959749
88MP0004883_abnormal_blood_vessel0.85668893
89MP0002019_abnormal_tumor_incidence0.84801074
90MP0004381_abnormal_hair_follicle0.81595451
91MP0000249_abnormal_blood_vessel0.80028505
92MP0000733_abnormal_muscle_development0.79482513
93MP0005165_increased_susceptibility_to0.78993746
94MP0003795_abnormal_bone_structure0.78232767
95MP0002138_abnormal_hepatobiliary_system0.77471874
96MP0005075_abnormal_melanosome_morpholog0.74329165
97MP0005275_abnormal_skin_tensile0.74261085
98MP0005164_abnormal_response_to0.73738708
99MP0009765_abnormal_xenobiotic_induced0.72828595
100MP0008260_abnormal_autophagy0.70643143
101MP0003183_abnormal_peptide_metabolism0.69653430
102MP0009763_increased_sensitivity_to0.69230686
103MP0003656_abnormal_erythrocyte_physiolo0.68128531
104MP0005451_abnormal_body_composition0.68091934
105MP0001663_abnormal_digestive_system0.68048068
106MP0008874_decreased_physiological_sensi0.67617844
107MP0009764_decreased_sensitivity_to0.67591427
108MP0000477_abnormal_intestine_morphology0.64913826
109MP0010678_abnormal_skin_adnexa0.64852474
110MP0002060_abnormal_skin_morphology0.64712321
111MP0001542_abnormal_bone_strength0.64412356
112MP0000377_abnormal_hair_follicle0.64171353
113MP0005083_abnormal_biliary_tract0.62325867
114MP0003045_fibrosis0.62245295
115MP0005319_abnormal_enzyme/_coenzyme0.59185892
116MP0005584_abnormal_enzyme/coenzyme_acti0.56291629
117MP0005381_digestive/alimentary_phenotyp0.53863074
118MP0000609_abnormal_liver_physiology0.53177506

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.12914716
2Eczematoid dermatitis (HP:0000976)4.68472365
3Elevated erythrocyte sedimentation rate (HP:0003565)4.28116941
4Chronic otitis media (HP:0000389)4.22567173
5Recurrent bacterial skin infections (HP:0005406)4.14754506
6Vacuolated lymphocytes (HP:0001922)4.12708385
7Abnormality of macrophages (HP:0004311)4.03863876
8Increased cerebral lipofuscin (HP:0011813)3.61486159
9Cellulitis (HP:0100658)3.57678655
10Obstructive lung disease (HP:0006536)3.43083300
11Chronic obstructive pulmonary disease (HP:0006510)3.43083300
12Myositis (HP:0100614)3.33344978
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.32299738
14Recurrent skin infections (HP:0001581)3.28458774
15Petechiae (HP:0000967)3.16901639
16IgM deficiency (HP:0002850)3.14944124
17Increased IgM level (HP:0003496)3.13104782
18Dysostosis multiplex (HP:0000943)3.09686041
19Recurrent fungal infections (HP:0002841)3.07450317
20Interstitial pulmonary disease (HP:0006530)3.06689878
21Stomatitis (HP:0010280)3.04054277
22Retrobulbar optic neuritis (HP:0100654)3.00579258
23Optic neuritis (HP:0100653)3.00579258
24Premature rupture of membranes (HP:0001788)2.93756163
25Encephalitis (HP:0002383)2.92502244
26Osteolytic defects of the phalanges of the hand (HP:0009771)2.91794590
27Osteolytic defects of the hand bones (HP:0009699)2.91794590
28Recurrent viral infections (HP:0004429)2.82309409
29Thrombocytosis (HP:0001894)2.81931823
30Spontaneous hematomas (HP:0007420)2.73924003
31Hepatosplenomegaly (HP:0001433)2.71394942
32Systemic lupus erythematosus (HP:0002725)2.71182530
33Nasal polyposis (HP:0100582)2.70598900
34Recurrent gram-negative bacterial infections (HP:0005420)2.68934044
35Agammaglobulinemia (HP:0004432)2.68143304
36Increased serum ferritin (HP:0003281)2.66403905
37Abnormality of the nasal mucosa (HP:0000433)2.64789038
38Loss of speech (HP:0002371)2.64310846
39Pulmonary infiltrates (HP:0002113)2.64301717
40Pustule (HP:0200039)2.62002819
41Peritonitis (HP:0002586)2.61573599
42Purpura (HP:0000979)2.59233582
43Gastrointestinal infarctions (HP:0005244)2.58323654
44Autoimmune thrombocytopenia (HP:0001973)2.56766118
45Recurrent bronchitis (HP:0002837)2.56200327
46Meningitis (HP:0001287)2.54482044
47Abnormality of glycolipid metabolism (HP:0010969)2.53748049
48Abnormality of liposaccharide metabolism (HP:0010968)2.53748049
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.53748049
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.49860867
51Chest pain (HP:0100749)2.49026554
52Mediastinal lymphadenopathy (HP:0100721)2.48851893
53Leukocytosis (HP:0001974)2.47893291
54Parakeratosis (HP:0001036)2.47655131
55Autoimmune hemolytic anemia (HP:0001890)2.47650557
56Vasculitis (HP:0002633)2.44666181
57Gastrointestinal stroma tumor (HP:0100723)2.42233068
58Vertebral compression fractures (HP:0002953)2.35089877
59Menorrhagia (HP:0000132)2.34711847
60Osteomyelitis (HP:0002754)2.31142596
61Inflammation of the large intestine (HP:0002037)2.30577363
62Hemoptysis (HP:0002105)2.29831738
63Colitis (HP:0002583)2.27690757
64Abnormality of iron homeostasis (HP:0011031)2.26768891
65Protrusio acetabuli (HP:0003179)2.24807751
66Emphysema (HP:0002097)2.23548754
67Gastrointestinal inflammation (HP:0004386)2.23219756
68Increased IgE level (HP:0003212)2.21914568
69Orchitis (HP:0100796)2.21116144
70Increased mean platelet volume (HP:0011877)2.19602266
71Eosinophilia (HP:0001880)2.19357990
72Gingivitis (HP:0000230)2.18587304
73Keratoconjunctivitis sicca (HP:0001097)2.17903124
74Urticaria (HP:0001025)2.17221222
75Arterial thrombosis (HP:0004420)2.16534770
76Thoracic kyphosis (HP:0002942)2.15786600
77Hypertensive crisis (HP:0100735)2.15460481
78Amyloidosis (HP:0011034)2.14822214
79Abnormality of the lumbar spine (HP:0100712)2.14325471
80Recurrent cutaneous fungal infections (HP:0011370)2.13962393
81Chronic mucocutaneous candidiasis (HP:0002728)2.13962393
82Hypergammaglobulinemia (HP:0010702)2.13717855
83Spondylolisthesis (HP:0003302)2.10509160
84Mucopolysacchariduria (HP:0008155)2.10431830
85Urinary glycosaminoglycan excretion (HP:0003541)2.10431830
86Skin ulcer (HP:0200042)2.10260185
87Episodic fever (HP:0001954)2.09726930
88Lymphopenia (HP:0001888)2.09675692
89Axonal loss (HP:0003447)2.07385252
90Abnormality of cells of the erythroid lineage (HP:0012130)2.07171563
91T lymphocytopenia (HP:0005403)2.04815410
92Abnormality of cells of the lymphoid lineage (HP:0012140)2.03041305
93Abnormality of the prostate (HP:0008775)2.02793346
94Abnormality of T cell physiology (HP:0011840)2.01752762
95Restrictive lung disease (HP:0002091)2.01711228
96Abnormal platelet volume (HP:0011876)1.99287378
97Progressive neurologic deterioration (HP:0002344)1.99196006
98Abnormality of T cells (HP:0002843)1.98973603
99J-shaped sella turcica (HP:0002680)1.98803290
100Granulocytopenia (HP:0001913)1.98343707
101IgG deficiency (HP:0004315)1.98090220
102Keratoconjunctivitis (HP:0001096)1.97859272
103Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97217808
104Chronic diarrhea (HP:0002028)1.96839198
105Glomerulopathy (HP:0100820)1.96475277
106Stridor (HP:0010307)1.96427073
107Pulmonary embolism (HP:0002204)1.96421806
108Abnormality of T cell number (HP:0011839)1.96133168
109Recurrent pneumonia (HP:0006532)1.96108846
110Joint swelling (HP:0001386)1.95128896
111Increased density of long bones (HP:0006392)1.94482691
112Recurrent lower respiratory tract infections (HP:0002783)1.94269958
113Abnormality of eosinophils (HP:0001879)1.94031717
114Abnormal delayed hypersensitivity skin test (HP:0002963)1.92729365
115Prolonged bleeding time (HP:0003010)1.92508196
116Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91203055
117Skin rash (HP:0000988)1.91202906
118Arthralgia (HP:0002829)1.90670457
119Aortic dissection (HP:0002647)1.90164735
120Epistaxis (HP:0000421)1.89722076
121Abnormal platelet function (HP:0011869)1.89075617
122Impaired platelet aggregation (HP:0003540)1.89075617
123Hematochezia (HP:0002573)1.88777169
124Abnormal number of erythroid precursors (HP:0012131)1.85641399
125Gingival bleeding (HP:0000225)1.85569561
126Panhypogammaglobulinemia (HP:0003139)1.85095036
127Abnormality of the peritoneum (HP:0002585)1.83959242
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83227326
129Abnormality of polysaccharide metabolism (HP:0011012)1.83227326
130Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83227326
131Ulnar bowing (HP:0003031)1.82696809
132Cervical subluxation (HP:0003308)1.82226323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.78064019
2EPHB13.33212184
3BLK2.98599528
4NME22.96561890
5TESK22.81900138
6IRAK42.30217944
7KIT2.29089665
8STK102.26199851
9PRPF4B2.04184604
10BTK1.95437663
11LRRK21.92393967
12TBK11.91942579
13PIM21.91001971
14ERN11.85380641
15CSF1R1.82364926
16JAK31.74531791
17ZAP701.70582995
18MST41.64574973
19TYK21.61881336
20KDR1.61064028
21STK391.59845747
22TRIB31.56843466
23FES1.56121247
24CSK1.55375195
25TAOK21.51611616
26LIMK11.48534420
27TEC1.46482687
28PKN21.44932420
29CLK11.44141824
30ITK1.44107620
31TNK21.36498590
32EEF2K1.34077679
33TRPM71.31204671
34MAP2K31.26259636
35LCK1.25812863
36IKBKB1.24520813
37TXK1.24046759
38FGR1.20329078
39TESK11.20181796
40IKBKE1.19923410
41HCK1.18465398
42TGFBR21.16199158
43SYK1.15338650
44TAOK11.14518175
45TTN1.12743534
46RPS6KA41.09309662
47PAK41.09168195
48ARAF1.06758159
49MAP3K111.05908381
50BMPR20.99313790
51MAP3K10.99141313
52MAP3K80.98671712
53LYN0.97657618
54SMG10.96530274
55FLT30.94184044
56TLK10.93559098
57SIK30.92280206
58MET0.90879336
59IRAK30.88785660
60BCKDK0.86747957
61EIF2AK30.86452180
62PIM10.86285389
63PBK0.85221198
64GRK60.83431336
65SCYL20.80828419
66CDK190.80365953
67MAP3K140.79271373
68MAPKAPK30.78040376
69RPS6KB20.77093766
70JAK10.73429227
71GRK70.71566661
72PDK10.69680150
73PDPK10.68275118
74NLK0.68044218
75MATK0.67887933
76CDC42BPA0.67021155
77SIK10.65175152
78PRKD20.63289532
79MOS0.62558792
80BMX0.62459425
81IRAK10.61817730
82BUB10.61004344
83MAPKAPK50.59607157
84MAP2K20.59526988
85CSNK1G30.59322988
86STK40.58508468
87PRKCQ0.57981183
88MAPKAPK20.57368128
89PAK20.56102411
90TAOK30.55195697
91ROCK20.54706286
92PTK60.54610201
93OXSR10.54385950
94EPHA30.54071951
95ABL10.53559091
96ABL20.52935289
97TNIK0.52831186
98FGFR40.51418599
99CSNK1A1L0.51336721
100RPS6KA50.50986998
101ILK0.50898071
102MARK30.49992343
103MAPK120.49788064
104MAPK110.47759660
105MAP3K30.47201866
106NEK90.47121309
107MAP3K130.46942512
108JAK20.46471972
109* PAK10.46445210
110DAPK10.45461385
111PTK2B0.44870337
112TGFBR10.44812325
113RIPK40.44740720
114MAP3K100.43957425
115WEE10.43911636
116CAMKK20.41979446
117EIF2AK10.41273026
118MYLK0.41141222
119PRKG20.40573479
120MAP3K50.39334725
121FYN0.38183630
122CSNK1G10.38001461
123IRAK20.37811704
124PIK3CG0.37441480
125MAPK40.37440846
126CDK40.37167283
127HIPK20.36975196
128PRKCD0.36720287
129MAP2K60.35940703
130NEK20.35175598
131KSR20.34632646
132RPS6KC10.33620349
133RPS6KL10.33620349
134MAP3K60.32885396

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.39466517
2Leishmaniasis_Homo sapiens_hsa051402.35785451
3Other glycan degradation_Homo sapiens_hsa005112.26671421
4Primary immunodeficiency_Homo sapiens_hsa053402.21832558
5Type I diabetes mellitus_Homo sapiens_hsa049402.10260787
6B cell receptor signaling pathway_Homo sapiens_hsa046622.05160454
7* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.98426870
8Malaria_Homo sapiens_hsa051441.96576134
9Lysosome_Homo sapiens_hsa041421.88436937
10Osteoclast differentiation_Homo sapiens_hsa043801.86927065
11Antigen processing and presentation_Homo sapiens_hsa046121.85464075
12Leukocyte transendothelial migration_Homo sapiens_hsa046701.83614824
13* Shigellosis_Homo sapiens_hsa051311.81255081
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.81025676
15* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.76068887
16Hematopoietic cell lineage_Homo sapiens_hsa046401.72430973
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68084722
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.62860307
19Measles_Homo sapiens_hsa051621.59147992
20Pertussis_Homo sapiens_hsa051331.58983540
21Proteasome_Homo sapiens_hsa030501.55382065
22DNA replication_Homo sapiens_hsa030301.54533910
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49953700
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46437744
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.44514473
26Staphylococcus aureus infection_Homo sapiens_hsa051501.44266987
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.39241081
28* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.38360334
29Apoptosis_Homo sapiens_hsa042101.34561394
30Tuberculosis_Homo sapiens_hsa051521.32953842
31Toxoplasmosis_Homo sapiens_hsa051451.32158453
32Phagosome_Homo sapiens_hsa041451.30297619
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27651635
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27488779
35Legionellosis_Homo sapiens_hsa051341.27302983
36Steroid biosynthesis_Homo sapiens_hsa001001.26491195
37T cell receptor signaling pathway_Homo sapiens_hsa046601.24888252
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23750355
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.20192394
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18279750
41* Salmonella infection_Homo sapiens_hsa051321.18158537
42Platelet activation_Homo sapiens_hsa046111.17224190
43Viral myocarditis_Homo sapiens_hsa054161.13051648
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11203173
45Asthma_Homo sapiens_hsa053101.09479960
46Acute myeloid leukemia_Homo sapiens_hsa052211.09292260
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09286996
48Sphingolipid metabolism_Homo sapiens_hsa006001.05274316
49Rheumatoid arthritis_Homo sapiens_hsa053231.02288439
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01569325
51Chronic myeloid leukemia_Homo sapiens_hsa052201.01380438
52Pentose phosphate pathway_Homo sapiens_hsa000301.00798692
53Hepatitis B_Homo sapiens_hsa051611.00467545
54Chemokine signaling pathway_Homo sapiens_hsa040620.99794739
55Herpes simplex infection_Homo sapiens_hsa051680.98554616
56Protein export_Homo sapiens_hsa030600.97040330
57Epstein-Barr virus infection_Homo sapiens_hsa051690.96545670
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94229875
59Graft-versus-host disease_Homo sapiens_hsa053320.94118134
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93677496
61Viral carcinogenesis_Homo sapiens_hsa052030.93124740
62Pancreatic cancer_Homo sapiens_hsa052120.92461073
63TNF signaling pathway_Homo sapiens_hsa046680.91598410
64Allograft rejection_Homo sapiens_hsa053300.89315495
65* Endocytosis_Homo sapiens_hsa041440.86172289
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83292909
67Small cell lung cancer_Homo sapiens_hsa052220.83230404
68Mismatch repair_Homo sapiens_hsa034300.83168300
69p53 signaling pathway_Homo sapiens_hsa041150.81312584
70African trypanosomiasis_Homo sapiens_hsa051430.80702559
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.79433085
72VEGF signaling pathway_Homo sapiens_hsa043700.76572824
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76545555
74Hepatitis C_Homo sapiens_hsa051600.76208020
75Autoimmune thyroid disease_Homo sapiens_hsa053200.75746248
76Galactose metabolism_Homo sapiens_hsa000520.75314586
77* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74304154
78ECM-receptor interaction_Homo sapiens_hsa045120.74011858
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73987496
80Influenza A_Homo sapiens_hsa051640.73132479
81Focal adhesion_Homo sapiens_hsa045100.71514089
82Homologous recombination_Homo sapiens_hsa034400.71389237
83Caffeine metabolism_Homo sapiens_hsa002320.71324786
84Amoebiasis_Homo sapiens_hsa051460.69995766
85Base excision repair_Homo sapiens_hsa034100.68978408
86Renal cell carcinoma_Homo sapiens_hsa052110.67907003
87Ether lipid metabolism_Homo sapiens_hsa005650.65214729
88Proteoglycans in cancer_Homo sapiens_hsa052050.65088833
89Renin-angiotensin system_Homo sapiens_hsa046140.64920145
90Non-small cell lung cancer_Homo sapiens_hsa052230.64532976
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62924055
92Fatty acid elongation_Homo sapiens_hsa000620.59391337
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59049161
94N-Glycan biosynthesis_Homo sapiens_hsa005100.58925750
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58695573
96Collecting duct acid secretion_Homo sapiens_hsa049660.58302043
97HTLV-I infection_Homo sapiens_hsa051660.56918741
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56483832
99Sulfur relay system_Homo sapiens_hsa041220.56117946
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56096686
101Spliceosome_Homo sapiens_hsa030400.55989924
102Glutathione metabolism_Homo sapiens_hsa004800.55362036
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54850403
104Bladder cancer_Homo sapiens_hsa052190.54142145
105Nucleotide excision repair_Homo sapiens_hsa034200.52878972
106Fructose and mannose metabolism_Homo sapiens_hsa000510.52830820
107Cell cycle_Homo sapiens_hsa041100.51840379
108Systemic lupus erythematosus_Homo sapiens_hsa053220.51781749
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51145593
110Non-homologous end-joining_Homo sapiens_hsa034500.51103537
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50688762
112MicroRNAs in cancer_Homo sapiens_hsa052060.49781893
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.39688680
114Prion diseases_Homo sapiens_hsa050200.36671192
115Vibrio cholerae infection_Homo sapiens_hsa051100.36480066
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.35603114
117Arachidonic acid metabolism_Homo sapiens_hsa005900.32871981
118Sulfur metabolism_Homo sapiens_hsa009200.29422656
119HIF-1 signaling pathway_Homo sapiens_hsa040660.26689948
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.26030686
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.21987565
122Prolactin signaling pathway_Homo sapiens_hsa049170.21087969
123Notch signaling pathway_Homo sapiens_hsa043300.20833343
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15322674
125Complement and coagulation cascades_Homo sapiens_hsa046100.14399575
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.12630853

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