ARNTL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.19741369
2cell adhesion mediated by integrin (GO:0033627)6.13558348
3keratinocyte proliferation (GO:0043616)5.43487593
4desmosome organization (GO:0002934)4.94006349
5superoxide anion generation (GO:0042554)4.57227018
6protein localization to endosome (GO:0036010)4.41826384
7mesodermal cell differentiation (GO:0048333)4.35314634
8hypotonic response (GO:0006971)4.26037174
9skin morphogenesis (GO:0043589)4.25661539
10cell-substrate junction assembly (GO:0007044)4.19613797
11substrate-dependent cell migration (GO:0006929)4.04715999
12keratinization (GO:0031424)3.90872255
13dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.75212357
14cellular protein complex localization (GO:0034629)3.73149356
15nuclear pore complex assembly (GO:0051292)3.69009023
16cellular response to vitamin D (GO:0071305)3.66938453
17regulation of transforming growth factor beta2 production (GO:0032909)3.59818451
18establishment of skin barrier (GO:0061436)3.46481106
19folic acid-containing compound biosynthetic process (GO:0009396)3.46463581
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.45065527
21keratinocyte differentiation (GO:0030216)3.43333467
22regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.41331644
23heterochromatin organization (GO:0070828)3.36507816
24nuclear pore organization (GO:0006999)3.36384385
25membrane raft organization (GO:0031579)3.35584242
26mesenchymal cell differentiation involved in kidney development (GO:0072161)3.33515749
27mesenchymal cell differentiation involved in renal system development (GO:2001012)3.33515749
28regulation of water loss via skin (GO:0033561)3.24408738
29UDP-N-acetylglucosamine metabolic process (GO:0006047)3.23555606
30protein localization to chromosome, centromeric region (GO:0071459)3.21957168
31hepatocyte differentiation (GO:0070365)3.15300385
32bundle of His cell to Purkinje myocyte communication (GO:0086069)3.14875211
33protein K6-linked ubiquitination (GO:0085020)3.13636571
34negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.11195583
35G-protein coupled receptor internalization (GO:0002031)3.09943589
36negative regulation of homotypic cell-cell adhesion (GO:0034111)3.07108056
37regulation of response to tumor cell (GO:0002834)3.05841276
38positive regulation of response to tumor cell (GO:0002836)3.05841276
39positive regulation of immune response to tumor cell (GO:0002839)3.05841276
40regulation of immune response to tumor cell (GO:0002837)3.05841276
41response to X-ray (GO:0010165)3.00995170
42mitotic sister chromatid cohesion (GO:0007064)2.99202748
43detection of other organism (GO:0098543)2.98786758
44regulation of keratinocyte proliferation (GO:0010837)2.98368967
45female gonad development (GO:0008585)2.97539249
46regulation of activation of Janus kinase activity (GO:0010533)2.96448292
47negative regulation of anoikis (GO:2000811)2.96343768
48positive regulation of cellular amide metabolic process (GO:0034250)2.95440988
49positive regulation of cell size (GO:0045793)2.94761527
50cellular response to vitamin (GO:0071295)2.94135720
51regulation of translational termination (GO:0006449)2.93162410
52polyketide metabolic process (GO:0030638)2.92971031
53doxorubicin metabolic process (GO:0044598)2.92971031
54daunorubicin metabolic process (GO:0044597)2.92971031
55pore complex assembly (GO:0046931)2.92787609
56protein localization to microtubule (GO:0035372)2.92490308
57wound healing, spreading of epidermal cells (GO:0035313)2.92373034
58regulation of protein export from nucleus (GO:0046825)2.90755268
59limb bud formation (GO:0060174)2.88963124
60positive regulation of interleukin-1 beta secretion (GO:0050718)2.88885987
61regulation of timing of cell differentiation (GO:0048505)2.88553491
62protein complex localization (GO:0031503)2.86436629
63protein localization to kinetochore (GO:0034501)2.85027871
64mitotic sister chromatid segregation (GO:0000070)2.84654920
65negative regulation of DNA repair (GO:0045738)2.84631386
66pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.84577397
67UMP biosynthetic process (GO:0006222)2.84577397
68pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.84577397
69UMP metabolic process (GO:0046049)2.84577397
70SMAD protein complex assembly (GO:0007183)2.84378431
71mitotic chromosome condensation (GO:0007076)2.84254400
72activation of Rac GTPase activity (GO:0032863)2.83884598
73positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.83584809
74regulation of cellular senescence (GO:2000772)2.81521225
75detection of bacterium (GO:0016045)2.81321724
76endodermal cell differentiation (GO:0035987)2.76999076
77sphingosine metabolic process (GO:0006670)2.76439760
78long-chain fatty acid biosynthetic process (GO:0042759)2.76005320
79G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.75815559
80cerebral cortex radially oriented cell migration (GO:0021799)2.74463687
81regulation of platelet aggregation (GO:0090330)2.74004123
82histone H3-K4 trimethylation (GO:0080182)2.73319601
83regulation of vitamin D biosynthetic process (GO:0060556)2.73013409
84righting reflex (GO:0060013)2.72708279
85DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.71939680
86nucleobase-containing small molecule interconversion (GO:0015949)2.71125393
87regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.70244066
88positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.70244066
89DNA integration (GO:0015074)2.69439402
90centriole assembly (GO:0098534)2.68081851
91regulation of metalloenzyme activity (GO:0048552)2.67760334
92nucleotide-sugar biosynthetic process (GO:0009226)2.67696220
93superoxide metabolic process (GO:0006801)2.66781203
94keratinocyte development (GO:0003334)2.66047940
95positive regulation of interleukin-1 secretion (GO:0050716)2.64755254
96histone-serine phosphorylation (GO:0035404)2.63394805
97pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.63216323
98energy homeostasis (GO:0097009)2.63127358
99meiotic chromosome segregation (GO:0045132)2.63015142
100adenosine metabolic process (GO:0046085)2.62471181
101establishment of planar polarity (GO:0001736)2.62445891
102establishment of tissue polarity (GO:0007164)2.62445891
103startle response (GO:0001964)2.61699824
104pyrimidine nucleoside salvage (GO:0043097)2.61353230
105pyrimidine-containing compound salvage (GO:0008655)2.61353230
106regulation of hippo signaling (GO:0035330)2.61143397
107developmental pigmentation (GO:0048066)2.60528896
108regulation of transforming growth factor beta1 production (GO:0032908)2.59936494
109negative regulation of mast cell activation (GO:0033004)2.59773326
110protein heterotetramerization (GO:0051290)2.58806799
111negative regulation of JAK-STAT cascade (GO:0046426)2.58468560
112cytoskeleton-dependent cytokinesis (GO:0061640)2.57622510
113gap junction assembly (GO:0016264)2.57587700
114cell differentiation involved in metanephros development (GO:0072202)2.57179545
115presynaptic membrane assembly (GO:0097105)2.56544078
116sister chromatid segregation (GO:0000819)2.55841231
117preassembly of GPI anchor in ER membrane (GO:0016254)2.55823904
118ribosome assembly (GO:0042255)2.55365103
119positive regulation of signal transduction by p53 class mediator (GO:1901798)2.52827290
120regulation of integrin activation (GO:0033623)2.51715070
121reflex (GO:0060004)2.50780150
122epidermal cell differentiation (GO:0009913)2.50482653
123trophoblast giant cell differentiation (GO:0060707)2.49565693
124regulation of interleukin-1 beta secretion (GO:0050706)2.49501003
125mitotic G1/S transition checkpoint (GO:0044819)2.48728512
126nucleoside salvage (GO:0043174)2.48203682
127DNA unwinding involved in DNA replication (GO:0006268)2.47761925
128purinergic nucleotide receptor signaling pathway (GO:0035590)2.47359010
129regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.47257055
130retina vasculature morphogenesis in camera-type eye (GO:0061299)2.46989109
131positive regulation of uterine smooth muscle contraction (GO:0070474)2.46613527
132mitotic metaphase plate congression (GO:0007080)2.46258891
133necroptotic process (GO:0070266)2.46159988
134microglial cell activation (GO:0001774)2.45946586
135regulation of DNA endoreduplication (GO:0032875)2.45219030
136regulation of dendritic cell antigen processing and presentation (GO:0002604)2.43985847
137tight junction assembly (GO:0070830)2.43658289
138negative regulation of myoblast differentiation (GO:0045662)2.43168882
139GPI anchor biosynthetic process (GO:0006506)2.42276019
140regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.42270501
141mitotic G1 DNA damage checkpoint (GO:0031571)2.42250270
142regulation of development, heterochronic (GO:0040034)2.41171490
143establishment of chromosome localization (GO:0051303)2.40933419
144response to peptidoglycan (GO:0032494)2.40579722
145dendritic cell chemotaxis (GO:0002407)2.38748006
146positive regulation of heat generation (GO:0031652)2.38009479
147retina layer formation (GO:0010842)2.37336861
148regulation of interleukin-8 secretion (GO:2000482)2.36904585
149presynaptic membrane organization (GO:0097090)2.36826085
150negative regulation of keratinocyte proliferation (GO:0010839)2.36461711
151lymphoid progenitor cell differentiation (GO:0002320)2.35787746
152photoreceptor cell maintenance (GO:0045494)2.34204523
153mesenchymal cell differentiation (GO:0048762)2.34095741
154positive regulation of defense response to virus by host (GO:0002230)2.32766794
155extracellular regulation of signal transduction (GO:1900115)2.32697278
156extracellular negative regulation of signal transduction (GO:1900116)2.32697278
157GPI anchor metabolic process (GO:0006505)2.32377561
158regulation of pigment cell differentiation (GO:0050932)2.32207972
159neutrophil activation (GO:0042119)2.31387219
160dendritic cell migration (GO:0036336)2.29164702
161T-helper cell differentiation (GO:0042093)2.29106050
162CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.29106050
163regulation of non-canonical Wnt signaling pathway (GO:2000050)2.28659914
164kidney morphogenesis (GO:0060993)2.27267430
165cell proliferation in forebrain (GO:0021846)2.27264341
166regulation of fever generation (GO:0031620)2.25644236
167positive regulation of action potential (GO:0045760)2.24456809
168detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.23930214
169ceramide catabolic process (GO:0046514)2.23626680
170positive regulation of interleukin-17 production (GO:0032740)2.23568139
171central nervous system myelination (GO:0022010)2.22602092
172axon ensheathment in central nervous system (GO:0032291)2.22602092
173cellular response to exogenous dsRNA (GO:0071360)2.22014792
174detection of molecule of bacterial origin (GO:0032490)2.21338175
175germinal center formation (GO:0002467)2.20864625
176positive regulation of interleukin-1 beta production (GO:0032731)2.20809380
177cranial nerve structural organization (GO:0021604)2.20019076
178negative regulation of DNA-dependent DNA replication (GO:2000104)2.18805314
179opioid receptor signaling pathway (GO:0038003)2.18232613
180positive regulation of protein homodimerization activity (GO:0090073)2.16668341
181oligosaccharide catabolic process (GO:0009313)2.16052469
182regulation of memory T cell differentiation (GO:0043380)2.15961703
183positive regulation of antigen processing and presentation (GO:0002579)2.15642356
184histone H3-K36 demethylation (GO:0070544)2.14724620
185response to host immune response (GO:0052572)2.14436639
186response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.14436639
187sympathetic nervous system development (GO:0048485)2.14399409
188negative regulation of execution phase of apoptosis (GO:1900118)2.13935991
189cranial nerve morphogenesis (GO:0021602)2.13494279
190modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.13085843
191positive regulation by organism of defense response of other organism involved in symbiotic interact2.13085843
192modulation by symbiont of host immune response (GO:0052553)2.13085843
193positive regulation by symbiont of host defense response (GO:0052509)2.13085843
194modulation by symbiont of host defense response (GO:0052031)2.13085843
195modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.13085843
196ganglion development (GO:0061548)2.12989455
197dentate gyrus development (GO:0021542)2.12654959
198facial nerve structural organization (GO:0021612)2.12340833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.12159321
2E2F7_22180533_ChIP-Seq_HELA_Human6.50850472
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human5.29910242
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.62246416
5GBX2_23144817_ChIP-Seq_PC3_Human3.78236715
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.56079304
7SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.36908230
8SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.36908230
9AR_21909140_ChIP-Seq_LNCAP_Human3.34079592
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.91882407
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.84790989
12EZH2_22144423_ChIP-Seq_EOC_Human2.74120548
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.65004597
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61467681
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57874301
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54884180
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48830672
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.43007545
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.28439065
20SUZ12_27294783_Chip-Seq_NPCs_Mouse2.27961247
21BRD4_25478319_ChIP-Seq_HGPS_Human2.24487753
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.23096474
23IGF1R_20145208_ChIP-Seq_DFB_Human2.20375889
24PCGF2_27294783_Chip-Seq_NPCs_Mouse2.19530831
25CJUN_26792858_Chip-Seq_BT549_Human2.17742547
26NFE2_27457419_Chip-Seq_LIVER_Mouse2.13865119
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13074685
28STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10250678
29CBX2_27304074_Chip-Seq_ESCs_Mouse2.06257344
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04744146
31* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.99349551
32TAF15_26573619_Chip-Seq_HEK293_Human1.94324029
33EZH2_27294783_Chip-Seq_NPCs_Mouse1.94105579
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.93782433
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92110697
36EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.91522434
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.91223035
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.90273322
39NANOG_18555785_Chip-Seq_ESCs_Mouse1.90219345
40FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.86635085
41* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85520407
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84785107
43SUZ12_18555785_Chip-Seq_ESCs_Mouse1.84211805
44E2F1_18555785_Chip-Seq_ESCs_Mouse1.83606219
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.83253807
46ELK1_19687146_ChIP-ChIP_HELA_Human1.82045163
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80510242
48STAT3_18555785_Chip-Seq_ESCs_Mouse1.79621595
49P53_22387025_ChIP-Seq_ESCs_Mouse1.79566135
50* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78567264
51* P300_19829295_ChIP-Seq_ESCs_Human1.76529014
52VDR_22108803_ChIP-Seq_LS180_Human1.73442661
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72982183
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.71925511
55EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.71526299
56NMYC_18555785_Chip-Seq_ESCs_Mouse1.71097972
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70539406
58CMYC_18555785_Chip-Seq_ESCs_Mouse1.70063087
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70014394
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69036155
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67835420
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67746944
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66924562
64* E2F1_21310950_ChIP-Seq_MCF-7_Human1.66019694
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65530314
66P300_18555785_Chip-Seq_ESCs_Mouse1.65088855
67RNF2_27304074_Chip-Seq_NSC_Mouse1.64776561
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62265489
69RUNX1_27457419_Chip-Seq_LIVER_Mouse1.61238278
70* ATF3_27146783_Chip-Seq_COLON_Human1.59449593
71OCT4_18555785_Chip-Seq_ESCs_Mouse1.58821182
72SOX2_18555785_Chip-Seq_ESCs_Mouse1.57690048
73TP63_23658742_ChIP-Seq_EP156T_Human1.55662666
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.54032919
75ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.54018752
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.53134612
77ZFX_18555785_Chip-Seq_ESCs_Mouse1.52987119
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.52975444
79FUS_26573619_Chip-Seq_HEK293_Human1.52289870
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.51769104
81PU1_27457419_Chip-Seq_LIVER_Mouse1.51348811
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.51151927
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49766498
84SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48564964
85KLF4_18555785_Chip-Seq_ESCs_Mouse1.48153441
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.47842911
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46045481
88ESRRB_18555785_Chip-Seq_ESCs_Mouse1.45382705
89SMAD4_21799915_ChIP-Seq_A2780_Human1.44259017
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43881804
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43580392
92SMAD1_18555785_Chip-Seq_ESCs_Mouse1.42149149
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40844294
94ER_23166858_ChIP-Seq_MCF-7_Human1.40451484
95CTCF_18555785_Chip-Seq_ESCs_Mouse1.40374051
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.40033463
97TP53_16413492_ChIP-PET_HCT116_Human1.39621207
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38447084
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36928850
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.36418461
101POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35408812
102EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35287629
103RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35287629
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34977436
105TP53_18474530_ChIP-ChIP_U2OS_Human1.34784877
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34323278
107SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34100100
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.34007185
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32974339
110IRF8_21731497_ChIP-ChIP_J774_Mouse1.32886166
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32739350
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32739350
113OCT4_21477851_ChIP-Seq_ESCs_Mouse1.32101905
114* TAL1_26923725_Chip-Seq_HPCs_Mouse1.32094201
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30586718
116* SOX2_20726797_ChIP-Seq_SW620_Human1.30442786
117RNF2_27304074_Chip-Seq_ESCs_Mouse1.30292009
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28973362
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28011085
120CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27599105
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26291381
122EWS_26573619_Chip-Seq_HEK293_Human1.25868193
123AR_21572438_ChIP-Seq_LNCaP_Human1.25840990
124P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24721924
125* EZH2_27294783_Chip-Seq_ESCs_Mouse1.23972235
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23591225
127EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.22712910
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20839950
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.19569864
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19305284
131* STAT3_23295773_ChIP-Seq_U87_Human1.19230055
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19137225
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19019649
134ZNF263_19887448_ChIP-Seq_K562_Human1.18687247
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16770587
136ELK1_22589737_ChIP-Seq_MCF10A_Human1.16766529
137SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16572729
138TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15501531
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15121534
140SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15043897
141KDM2B_26808549_Chip-Seq_REH_Human1.14022692
142IRF1_19129219_ChIP-ChIP_H3396_Human1.12578133
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12475096
144DCP1A_22483619_ChIP-Seq_HELA_Human1.11402868
145RUNX2_22187159_ChIP-Seq_PCA_Human1.11066029
146* TCF4_23295773_ChIP-Seq_U87_Human1.10893840
147LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10615582
148PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.10181288
149NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09999113
150NOTCH1_21737748_ChIP-Seq_TLL_Human1.09130820
151IRF8_22096565_ChIP-ChIP_GC-B_Human1.08870107
152GATA6_25053715_ChIP-Seq_YYC3_Human1.07995345
153TP53_22127205_ChIP-Seq_IMR90_Human1.07824323
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07481330
155CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06693045
156GATA4_25053715_ChIP-Seq_YYC3_Human1.06384056
157MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04702803
158KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04283870
159CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03193319
160* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02890115
161FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02219241
162P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00427626
163PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95966079
164* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95521543
165MYC_19030024_ChIP-ChIP_MESCs_Mouse0.89995074
166Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89036714
167CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88433722
168ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88077642
169GATA3_24758297_ChIP-Seq_MCF-7_Human0.87745547
170SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87008574
171MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86936509
172MYC_19079543_ChIP-ChIP_MESCs_Mouse0.83568553
173SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82466234
174ELF5_23300383_ChIP-Seq_T47D_Human0.81954848
175* SOX17_20123909_ChIP-Seq_XEN_Mouse0.81858222
176FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81724546
177CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80830838
178* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80211625
179TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.78825955
180STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78805258
181MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.78091013
182AHR_22903824_ChIP-Seq_MCF-7_Human0.77013788
183* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.76459149
184ESR1_21235772_ChIP-Seq_MCF-7_Human0.76365469
185KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.76162649
186MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.74650343
187STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72877083
188FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.71705932
189NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.70348260
190EP300_21415370_ChIP-Seq_HL-1_Mouse0.70125449
191KLF5_25053715_ChIP-Seq_YYC3_Human0.69819794
192CDX2_22108803_ChIP-Seq_LS180_Human0.68230166
193STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.68153597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.90258244
2MP0010352_gastrointestinal_tract_polyps3.71503555
3MP0002102_abnormal_ear_morphology3.58623909
4MP0003136_yellow_coat_color3.57034097
5MP0010234_abnormal_vibrissa_follicle3.41281208
6MP0006292_abnormal_olfactory_placode3.40947854
7MP0000566_synostosis3.40341557
8MP0002234_abnormal_pharynx_morphology3.39710970
9MP0003566_abnormal_cell_adhesion3.22606048
10MP0003705_abnormal_hypodermis_morpholog2.92029895
11MP0005623_abnormal_meninges_morphology2.85786849
12MP0002796_impaired_skin_barrier2.60123025
13MP0002877_abnormal_melanocyte_morpholog2.53157846
14MP0002277_abnormal_respiratory_mucosa2.49470358
15MP0010678_abnormal_skin_adnexa2.49309751
16MP0005409_darkened_coat_color2.45023698
17MP0009053_abnormal_anal_canal2.42773296
18MP0004381_abnormal_hair_follicle2.41180280
19MP0005023_abnormal_wound_healing2.36589807
20MP0000467_abnormal_esophagus_morphology2.34715197
21MP0001216_abnormal_epidermal_layer2.33195211
22MP0005171_absent_coat_pigmentation2.30749494
23MP0010368_abnormal_lymphatic_system2.30306644
24MP0001986_abnormal_taste_sensitivity2.28306458
25MP0002060_abnormal_skin_morphology2.26855745
26MP0003453_abnormal_keratinocyte_physiol2.22723342
27MP0010094_abnormal_chromosome_stability2.06122121
28MP0005645_abnormal_hypothalamus_physiol2.03848888
29MP0000762_abnormal_tongue_morphology2.03702870
30MP0000015_abnormal_ear_pigmentation2.02010131
31MP0003941_abnormal_skin_development1.97172956
32MP0004272_abnormal_basement_membrane1.96689251
33MP0000569_abnormal_digit_pigmentation1.89543504
34MP0005275_abnormal_skin_tensile1.88370896
35MP0005646_abnormal_pituitary_gland1.86085729
36MP0005501_abnormal_skin_physiology1.85993633
37MP0002148_abnormal_hypersensitivity_rea1.82971255
38MP0005174_abnormal_tail_pigmentation1.81615353
39MP0003787_abnormal_imprinting1.79901698
40MP0003091_abnormal_cell_migration1.77933575
41MP0003880_abnormal_central_pattern1.77048423
42MP0001835_abnormal_antigen_presentation1.73720721
43MP0010307_abnormal_tumor_latency1.73661492
44MP0003693_abnormal_embryo_hatching1.71405977
45MP0004742_abnormal_vestibular_system1.71394015
46MP0008007_abnormal_cellular_replicative1.67960422
47MP0001486_abnormal_startle_reflex1.67883028
48MP0005379_endocrine/exocrine_gland_phen1.64849005
49MP0004957_abnormal_blastocyst_morpholog1.64195040
50MP0000383_abnormal_hair_follicle1.59565414
51MP0010386_abnormal_urinary_bladder1.57232236
52MP0008260_abnormal_autophagy1.56140019
53MP0002163_abnormal_gland_morphology1.56092384
54MP0003806_abnormal_nucleotide_metabolis1.52370797
55MP0001346_abnormal_lacrimal_gland1.51834482
56MP0010771_integument_phenotype1.50246579
57MP0003724_increased_susceptibility_to1.47814587
58MP0003111_abnormal_nucleus_morphology1.47733366
59MP0005451_abnormal_body_composition1.46633184
60MP0005671_abnormal_response_to1.45904782
61MP0009785_altered_susceptibility_to1.44189771
62MP0000537_abnormal_urethra_morphology1.41667801
63MP0000026_abnormal_inner_ear1.39999303
64MP0002638_abnormal_pupillary_reflex1.39304539
65MP0009697_abnormal_copulation1.37779309
66MP0008995_early_reproductive_senescence1.36446353
67MP0001879_abnormal_lymphatic_vessel1.34956471
68MP0002735_abnormal_chemical_nociception1.34196632
69MP0001790_abnormal_immune_system1.33418115
70MP0005387_immune_system_phenotype1.33418115
71MP0005423_abnormal_somatic_nervous1.33274820
72MP0000013_abnormal_adipose_tissue1.32053848
73MP0001348_abnormal_lacrimal_gland1.30340898
74MP0004233_abnormal_muscle_weight1.29730385
75MP0002938_white_spotting1.29032443
76MP0003045_fibrosis1.27928939
77MP0008058_abnormal_DNA_repair1.27731841
78MP0000372_irregular_coat_pigmentation1.27320284
79MP0000427_abnormal_hair_cycle1.26427347
80MP0003300_gastrointestinal_ulcer1.26332883
81MP0003315_abnormal_perineum_morphology1.25045922
82MP0002006_tumorigenesis1.24099406
83MP0000733_abnormal_muscle_development1.22466086
84MP0000627_abnormal_mammary_gland1.20211653
85MP0002138_abnormal_hepatobiliary_system1.19868155
86MP0002876_abnormal_thyroid_physiology1.19636500
87MP0003938_abnormal_ear_development1.16314377
88MP0004947_skin_inflammation1.15840597
89MP0001849_ear_inflammation1.15746470
90MP0004142_abnormal_muscle_tone1.15164003
91MP0000858_altered_metastatic_potential1.14916514
92MP0002419_abnormal_innate_immunity1.13388682
93MP0002249_abnormal_larynx_morphology1.12885683
94MP0002736_abnormal_nociception_after1.12572850
95MP0001963_abnormal_hearing_physiology1.10798533
96MP0008932_abnormal_embryonic_tissue1.09799770
97MP0005000_abnormal_immune_tolerance1.09342600
98MP0000350_abnormal_cell_proliferation1.09183328
99MP0008438_abnormal_cutaneous_collagen1.08741744
100MP0004043_abnormal_pH_regulation1.08575654
101MP0003077_abnormal_cell_cycle1.07386916
102MP0002132_abnormal_respiratory_system1.06158915
103MP0004782_abnormal_surfactant_physiolog1.06021323
104MP0001968_abnormal_touch/_nociception1.03791209
105MP0001502_abnormal_circadian_rhythm1.02803959
106MP0005551_abnormal_eye_electrophysiolog1.02496694
107MP0005197_abnormal_uvea_morphology1.02011337
108MP0005076_abnormal_cell_differentiation1.00274916
109MP0005025_abnormal_response_to0.99743682
110MP0001191_abnormal_skin_condition0.98335156
111MP0006276_abnormal_autonomic_nervous0.97889459
112MP0002095_abnormal_skin_pigmentation0.97388173
113MP0003786_premature_aging0.97254078
114MP0006054_spinal_hemorrhage0.96109710
115MP0000049_abnormal_middle_ear0.95601684
116MP0008004_abnormal_stomach_pH0.95199086
117MP0005310_abnormal_salivary_gland0.94428355
118MP0002452_abnormal_antigen_presenting0.94359205
119MP0003718_maternal_effect0.91653456
120MP0002723_abnormal_immune_serum0.91610996
121MP0009046_muscle_twitch0.91286979
122MP0003755_abnormal_palate_morphology0.90919557
123MP0009764_decreased_sensitivity_to0.90298253
124MP0000377_abnormal_hair_follicle0.89197588
125MP0001984_abnormal_olfaction0.88986184
126MP0000647_abnormal_sebaceous_gland0.88376069
127MP0001800_abnormal_humoral_immune0.87705642
128MP0005075_abnormal_melanosome_morpholog0.87195954
129MP0002009_preneoplasia0.86614798
130MP0003448_altered_tumor_morphology0.86565785
131MP0002177_abnormal_outer_ear0.86461279
132MP0005621_abnormal_cell_physiology0.85767451
133MP0000579_abnormal_nail_morphology0.85366202
134MP0001485_abnormal_pinna_reflex0.84813653
135MP0009745_abnormal_behavioral_response0.84350590
136MP0003937_abnormal_limbs/digits/tail_de0.83995931
137MP0003878_abnormal_ear_physiology0.83788428
138MP0005377_hearing/vestibular/ear_phenot0.83788428
139MP0000631_abnormal_neuroendocrine_gland0.82983086
140MP0000778_abnormal_nervous_system0.82506501
141MP0005253_abnormal_eye_physiology0.82026476
142MP0003950_abnormal_plasma_membrane0.81645013
143MP0001905_abnormal_dopamine_level0.81427411
144MP0006082_CNS_inflammation0.81342225
145MP0002067_abnormal_sensory_capabilities0.80999272
146MP0003191_abnormal_cellular_cholesterol0.80903237
147MP0000490_abnormal_crypts_of0.80045391
148MP0003868_abnormal_feces_composition0.79568172
149MP0005257_abnormal_intraocular_pressure0.79417040
150MP0001243_abnormal_dermal_layer0.79364067
151MP0008057_abnormal_DNA_replication0.79153434
152MP0002557_abnormal_social/conspecific_i0.78996423
153MP0000767_abnormal_smooth_muscle0.78804909
154MP0001819_abnormal_immune_cell0.76531166
155MP0001672_abnormal_embryogenesis/_devel0.76442465
156MP0005380_embryogenesis_phenotype0.76442465
157MP0002168_other_aberrant_phenotype0.76401069
158MP0001501_abnormal_sleep_pattern0.76201635
159MP0005164_abnormal_response_to0.75996970
160MP0001299_abnormal_eye_distance/0.75714228
161MP0000003_abnormal_adipose_tissue0.75482911
162MP0000358_abnormal_cell_content/0.74786288
163MP0002086_abnormal_extraembryonic_tissu0.74645721
164MP0000470_abnormal_stomach_morphology0.74480853
165MP0002420_abnormal_adaptive_immunity0.73762766
166MP0002572_abnormal_emotion/affect_behav0.73171356
167MP0005165_increased_susceptibility_to0.72635317
168MP0002084_abnormal_developmental_patter0.72104829
169MP0002272_abnormal_nervous_system0.71888478
170MP0000681_abnormal_thyroid_gland0.71769083
171MP0000432_abnormal_head_morphology0.71737718
172MP0003984_embryonic_growth_retardation0.71505843
173MP0009250_abnormal_appendicular_skeleto0.70927346
174MP0002098_abnormal_vibrissa_morphology0.70373611
175MP0004185_abnormal_adipocyte_glucose0.69152274
176MP0001186_pigmentation_phenotype0.68890920
177MP0002752_abnormal_somatic_nervous0.67349678
178MP0002088_abnormal_embryonic_growth/wei0.66437061
179MP0004134_abnormal_chest_morphology0.65933958
180MP0002998_abnormal_bone_remodeling0.65579409
181MP0005395_other_phenotype0.64799602
182MP0001697_abnormal_embryo_size0.64335985
183MP0000613_abnormal_salivary_gland0.63159555

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)6.26542480
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.50529337
3Plantar hyperkeratosis (HP:0007556)5.37115742
4Milia (HP:0001056)5.35397683
5Abnormality of nail color (HP:0100643)4.94600540
6Fragile nails (HP:0001808)4.90090914
7Chromsome breakage (HP:0040012)4.85079615
8Thick nail (HP:0001805)4.67319407
9Atrophic scars (HP:0001075)4.57253741
10Palmoplantar hyperkeratosis (HP:0000972)4.35398700
11Palmar hyperkeratosis (HP:0010765)4.15407477
12Nail dystrophy (HP:0008404)3.92237171
13Ridged nail (HP:0001807)3.85223148
14Alopecia of scalp (HP:0002293)3.78077311
15Selective tooth agenesis (HP:0001592)3.63210559
16Duplicated collecting system (HP:0000081)3.49380160
17Natal tooth (HP:0000695)3.32276414
18Prostate neoplasm (HP:0100787)3.31539503
19Abnormality of the renal collecting system (HP:0004742)3.27534830
20Poikiloderma (HP:0001029)3.24375679
21Ankyloglossia (HP:0010296)3.16926939
22Septo-optic dysplasia (HP:0100842)3.16077249
23Oral leukoplakia (HP:0002745)3.14307257
24Aplasia cutis congenita (HP:0001057)3.05033895
25White forelock (HP:0002211)2.95459155
26Febrile seizures (HP:0002373)2.93623700
27Reduced subcutaneous adipose tissue (HP:0003758)2.92771811
28Retrobulbar optic neuritis (HP:0100654)2.91132774
29Optic neuritis (HP:0100653)2.91132774
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.90094612
31Absent/shortened dynein arms (HP:0200106)2.90094612
32Abnormality of oral frenula (HP:0000190)2.88513309
33Patchy hypopigmentation of hair (HP:0011365)2.80834158
34Abnormality of incisor morphology (HP:0011063)2.76645677
35Fragile skin (HP:0001030)2.74810798
36Amniotic constriction ring (HP:0009775)2.68041103
37Abnormality of placental membranes (HP:0011409)2.68041103
38Abnormal blistering of the skin (HP:0008066)2.67813171
39Abnormality of DNA repair (HP:0003254)2.67474342
40Abnormal ciliary motility (HP:0012262)2.66835173
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61977410
42Hypoplasia of dental enamel (HP:0006297)2.60057834
43Parakeratosis (HP:0001036)2.59198077
44Fibular aplasia (HP:0002990)2.58973857
45Trismus (HP:0000211)2.57545478
46Pterygium (HP:0001059)2.57069879
47Congenital sensorineural hearing impairment (HP:0008527)2.55595855
48Hypoplastic labia majora (HP:0000059)2.55166313
49Conical tooth (HP:0000698)2.51984980
50Clubbing of toes (HP:0100760)2.47735281
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.45376567
52Absent eyelashes (HP:0000561)2.44022277
53Duplication of thumb phalanx (HP:0009942)2.43573912
54Squamous cell carcinoma (HP:0002860)2.43030500
55True hermaphroditism (HP:0010459)2.41235519
56Abnormality of the preputium (HP:0100587)2.36358718
57Sparse eyelashes (HP:0000653)2.36167701
58Ureteral duplication (HP:0000073)2.34393609
59Decreased central vision (HP:0007663)2.34059562
60Breast hypoplasia (HP:0003187)2.32346142
61Chronic hepatic failure (HP:0100626)2.30982641
62Osteomalacia (HP:0002749)2.30947481
63Abnormal hair whorl (HP:0010721)2.30332229
64Congenital stationary night blindness (HP:0007642)2.29742906
65Recurrent abscess formation (HP:0002722)2.28490108
66Tubulointerstitial nephritis (HP:0001970)2.23335887
67Ectopic kidney (HP:0000086)2.22568811
68Follicular hyperkeratosis (HP:0007502)2.22190620
69Right ventricular cardiomyopathy (HP:0011663)2.21648141
70Osteolytic defects of the hand bones (HP:0009699)2.21387224
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.21387224
72Optic nerve hypoplasia (HP:0000609)2.21320832
73Abnormal hair laboratory examination (HP:0003328)2.19897984
74Upper limb muscle weakness (HP:0003484)2.19772893
75Hypoplasia of the fovea (HP:0007750)2.19234789
76Aplasia/Hypoplasia of the fovea (HP:0008060)2.19234789
77Absent septum pellucidum (HP:0001331)2.17635936
78Ureteral stenosis (HP:0000071)2.17436510
79Meckel diverticulum (HP:0002245)2.17237297
80Oligodontia (HP:0000677)2.16371788
81Abnormality of the nasal septum (HP:0000419)2.16206353
82Abnormality of the labia majora (HP:0012881)2.15713760
83Recurrent pneumonia (HP:0006532)2.14916920
84Abnormal respiratory motile cilium physiology (HP:0012261)2.14452951
85Cardiovascular calcification (HP:0011915)2.14392875
86Sparse scalp hair (HP:0002209)2.14147863
87Abnormal respiratory epithelium morphology (HP:0012253)2.11936594
88Abnormal respiratory motile cilium morphology (HP:0005938)2.11936594
89Corneal erosion (HP:0200020)2.11746814
90Lip pit (HP:0100267)2.11729234
91Stomach cancer (HP:0012126)2.11644710
92Short nail (HP:0001799)2.10659666
93Ureteral obstruction (HP:0006000)2.09382485
94Renal cortical cysts (HP:0000803)2.09269180
95Abnormality of the ileum (HP:0001549)2.08180672
96Hypoplastic toenails (HP:0001800)2.07536928
97Premature rupture of membranes (HP:0001788)2.07042065
98Nephronophthisis (HP:0000090)2.06177371
99Hypothermia (HP:0002045)2.05361753
100Popliteal pterygium (HP:0009756)2.05133725
101Autoimmune thrombocytopenia (HP:0001973)2.04452614
102Abnormality of the renal medulla (HP:0100957)2.03285186
103Blepharitis (HP:0000498)2.02357043
104Orchitis (HP:0100796)2.01795321
105Alveolar cell carcinoma (HP:0006519)2.01611858
106Erythroderma (HP:0001019)2.01351706
107Abnormality of the septum pellucidum (HP:0007375)1.99963559
108Chronic mucocutaneous candidiasis (HP:0002728)1.99487208
109Recurrent cutaneous fungal infections (HP:0011370)1.99487208
110Pancreatic fibrosis (HP:0100732)1.98872672
111Hypotrichosis (HP:0001006)1.97997020
112Entropion (HP:0000621)1.97942264
113Subacute progressive viral hepatitis (HP:0006572)1.97352875
114Nasolacrimal duct obstruction (HP:0000579)1.96415516
115Abnormality of the distal phalanges of the toes (HP:0010182)1.96040861
116Vascular calcification (HP:0004934)1.95776424
117Erythema (HP:0010783)1.94267959
118Fair hair (HP:0002286)1.91441967
119Septate vagina (HP:0001153)1.91418494
120Anomalous pulmonary venous return (HP:0010772)1.91377051
121Xerostomia (HP:0000217)1.90397458
122Obstructive lung disease (HP:0006536)1.90120240
123Chronic obstructive pulmonary disease (HP:0006510)1.90120240
124Focal segmental glomerulosclerosis (HP:0000097)1.90083082
125Preaxial hand polydactyly (HP:0001177)1.89944360
126Cheilitis (HP:0100825)1.89827072
127Medial flaring of the eyebrow (HP:0010747)1.89445128
128Attenuation of retinal blood vessels (HP:0007843)1.88427832
129Pancreatic cysts (HP:0001737)1.88069015
130Abnormality of chromosome stability (HP:0003220)1.86348959
131Increased IgM level (HP:0003496)1.85960796
132Ectropion (HP:0000656)1.85723096
133Deviation of the thumb (HP:0009603)1.85669030
134Median cleft lip (HP:0000161)1.85277821
135Hyperacusis (HP:0010780)1.84830459
136Male pseudohermaphroditism (HP:0000037)1.84029180
137Ankle contracture (HP:0006466)1.83085810
138Submucous cleft hard palate (HP:0000176)1.82862898
139Pili torti (HP:0003777)1.82697268
140Congenital ichthyosiform erythroderma (HP:0007431)1.81759373
141Recurrent bacterial skin infections (HP:0005406)1.81342047
142Abnormality of the prostate (HP:0008775)1.81315371
143Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81177531
144Advanced eruption of teeth (HP:0006288)1.78354383
145Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.77718357
146Abnormality of molar (HP:0011077)1.77615816
147Abnormality of molar morphology (HP:0011070)1.77615816
148Dry hair (HP:0011359)1.76642036
149Abnormality of the salivary glands (HP:0010286)1.76596731
150Chronic diarrhea (HP:0002028)1.75827845
151Myositis (HP:0100614)1.75579239
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73957901
153Duodenal stenosis (HP:0100867)1.73827989
154Small intestinal stenosis (HP:0012848)1.73827989
155Congenital hepatic fibrosis (HP:0002612)1.72678123
156Pulmonary artery stenosis (HP:0004415)1.72492902
157Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.72323997
158Sparse lateral eyebrow (HP:0005338)1.71942909
159Neoplasm of the tracheobronchial system (HP:0100552)1.71251187
160Abnormality of the lacrimal duct (HP:0011481)1.70331904
161Focal motor seizures (HP:0011153)1.70170120
162Abnormality of the pulmonary veins (HP:0011718)1.70130694
163Abnormality of the nasolacrimal system (HP:0000614)1.69964990
164Increased corneal curvature (HP:0100692)1.69278101
165Keratoconus (HP:0000563)1.69278101
166Protruding tongue (HP:0010808)1.68638102
167Abnormality of the renal cortex (HP:0011035)1.68070439
168Generalized hypopigmentation of hair (HP:0011358)1.67077256
169Short chin (HP:0000331)1.67050435
170Nephrogenic diabetes insipidus (HP:0009806)1.66480245
171IgA deficiency (HP:0002720)1.66425821
172Nephroblastoma (Wilms tumor) (HP:0002667)1.66255059
173Carious teeth (HP:0000670)1.65825321
174Abnormality of the fovea (HP:0000493)1.65719184
175Hypergonadotropic hypogonadism (HP:0000815)1.65613197
176Uterine leiomyosarcoma (HP:0002891)1.64880308
177Leiomyosarcoma (HP:0100243)1.64880308
178Palmoplantar keratoderma (HP:0000982)1.64379778
179Eczematoid dermatitis (HP:0000976)1.64329280
180Abnormality of the carotid arteries (HP:0005344)1.64320419
181Bladder carcinoma (HP:0002862)1.64018114
182Bladder neoplasm (HP:0009725)1.64018114
183Rough bone trabeculation (HP:0100670)1.64017821
184Capillary hemangiomas (HP:0005306)1.61026141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.33098739
2CASK3.68139870
3EPHA23.59827287
4MET3.41759212
5TNIK3.29562419
6MAP3K142.67949621
7IRAK32.47790694
8EIF2AK32.40152533
9IRAK42.38827119
10TXK2.36146352
11ZAK2.35627690
12INSRR2.33421259
13TGFBR12.25369345
14MAP3K92.23110490
15BUB12.18302122
16NUAK12.17680859
17PTK22.17664537
18STK162.17042631
19MKNK22.07200456
20EIF2AK22.04896209
21BLK2.02575876
22EIF2AK11.99089892
23ERBB41.91256851
24SIK31.90303726
25BMPR21.88989175
26BMPR1B1.82183842
27PRPF4B1.81086490
28MAP2K71.72936037
29ADRBK21.72933553
30NME21.66695169
31NEK61.64463766
32NEK91.63509369
33MUSK1.59655031
34NEK11.59095915
35SCYL21.58521573
36GRK11.56576811
37PAK41.55044791
38YES11.53353878
39TAF11.51250708
40WNK41.50543075
41CDK31.49114528
42CDC71.49095984
43PDGFRA1.46768319
44STK101.44737718
45GRK71.43606627
46IRAK11.34588338
47STK31.33672327
48MAPK131.33038405
49RIPK41.31448569
50IKBKE1.30161891
51LMTK21.27558790
52IKBKB1.26867372
53MELK1.25980025
54CCNB11.25680762
55TEC1.25568877
56LATS21.25298599
57MKNK11.21706545
58TTK1.21662971
59IRAK21.20426157
60PKN11.18331613
61MAP3K31.15617791
62MAP3K131.15229950
63STK38L1.15142104
64MOS1.13830929
65CHEK21.13608062
66ILK1.11728127
67PBK1.10777385
68ERBB31.08161353
69BRSK21.05908094
70NLK1.02714768
71TSSK61.02433764
72TNK20.97109231
73NTRK30.95333093
74MAPK150.89168835
75BRD40.88672007
76MAP3K20.87988424
77PLK40.85768160
78WEE10.83437032
79FLT30.83149048
80PRKCE0.82763220
81CDK80.80871099
82CLK10.80321116
83LIMK10.79733455
84NTRK10.77893421
85PIK3CA0.77455874
86SGK20.75423633
87SRPK10.75410733
88CHUK0.75147326
89PNCK0.74763445
90EEF2K0.73300114
91VRK10.72918063
92PLK30.70924443
93EPHA30.70887751
94LATS10.70738051
95TAOK30.67893308
96PRKCI0.67507561
97JAK30.65960447
98ARAF0.65524915
99PTK2B0.65381781
100TRPM70.65060283
101LYN0.63649009
102BCR0.63348038
103OXSR10.62869944
104PLK10.61865542
105PLK20.60626921
106PIK3CG0.60242238
107AURKB0.58156299
108KIT0.58109648
109MAP3K80.57782163
110TTN0.57445756
111TIE10.55630305
112MST40.54543934
113SIK20.53858694
114AKT30.53706794
115FGR0.53701844
116TRIM280.51498006
117DYRK20.50840024
118PDGFRB0.50536896
119STK390.49912620
120ABL20.49864789
121JAK10.49596868
122SGK10.49415562
123NTRK20.49203785
124MAPK70.48885131
125SGK2230.48667195
126SGK4940.48667195
127KSR10.48604019
128PRKCQ0.48274883
129RPS6KA50.47769553
130PAK20.47575060
131BTK0.47191173
132EPHB20.45031385
133PINK10.44621247
134MAP3K120.44447084
135MAPKAPK50.42990342
136DDR20.42932522
137TLK10.41860315
138CDK90.41334255
139PIM20.41065985
140OBSCN0.40691714
141STK240.40423940
142RPS6KB20.39942587
143PRKG10.39924890
144TBK10.39685965
145FES0.39009444
146EPHA40.38655498
147PRKAA20.38586650
148PRKD20.38063657
149WNK10.37641465
150SYK0.37525947
151CAMK2A0.36904714
152LCK0.36841053
153HCK0.36783206
154CDK70.35991551
155BRAF0.35961706
156AURKA0.35832350
157BMX0.35182543
158TGFBR20.33479786
159SMG10.33328622
160CAMK10.33141441
161STK40.32739766
162CSNK1A1L0.30678567
163AKT20.27357011
164ATM0.27159828
165NEK20.24972943
166CHEK10.24185546

Predicted pathways (KEGG)

RankGene SetZ-score
1p53 signaling pathway_Homo sapiens_hsa041152.58143655
2Small cell lung cancer_Homo sapiens_hsa052222.39447106
3ECM-receptor interaction_Homo sapiens_hsa045122.35706209
4Graft-versus-host disease_Homo sapiens_hsa053322.24607511
5DNA replication_Homo sapiens_hsa030302.22347778
6Fanconi anemia pathway_Homo sapiens_hsa034602.19614772
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19583149
8Bladder cancer_Homo sapiens_hsa052192.18775199
9One carbon pool by folate_Homo sapiens_hsa006702.09841401
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.07403237
11Allograft rejection_Homo sapiens_hsa053302.06027639
12Autoimmune thyroid disease_Homo sapiens_hsa053202.04408412
13Nicotine addiction_Homo sapiens_hsa050332.02755964
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.00328320
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00270819
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.98558225
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.97237447
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96437549
19Vitamin B6 metabolism_Homo sapiens_hsa007501.93154686
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93146200
21Cell cycle_Homo sapiens_hsa041101.91992268
22Proteoglycans in cancer_Homo sapiens_hsa052051.86269325
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86231898
24Nucleotide excision repair_Homo sapiens_hsa034201.85370596
25Shigellosis_Homo sapiens_hsa051311.85289676
26Focal adhesion_Homo sapiens_hsa045101.84059641
27Selenocompound metabolism_Homo sapiens_hsa004501.81087422
28Pyrimidine metabolism_Homo sapiens_hsa002401.81023319
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.79332077
30Adherens junction_Homo sapiens_hsa045201.77381891
31Phototransduction_Homo sapiens_hsa047441.76149204
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.60888770
33Rheumatoid arthritis_Homo sapiens_hsa053231.57801958
34Sphingolipid metabolism_Homo sapiens_hsa006001.56820848
35Sulfur metabolism_Homo sapiens_hsa009201.56642753
36Mismatch repair_Homo sapiens_hsa034301.54526261
37Asthma_Homo sapiens_hsa053101.52989208
38MicroRNAs in cancer_Homo sapiens_hsa052061.51777414
39Hippo signaling pathway_Homo sapiens_hsa043901.49710346
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48244848
41Ether lipid metabolism_Homo sapiens_hsa005651.45906483
42Proteasome_Homo sapiens_hsa030501.45518108
43Arachidonic acid metabolism_Homo sapiens_hsa005901.43685972
44Hematopoietic cell lineage_Homo sapiens_hsa046401.43228949
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43159635
46Taste transduction_Homo sapiens_hsa047421.42421892
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41485115
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40930688
49Pancreatic cancer_Homo sapiens_hsa052121.39883340
50Non-homologous end-joining_Homo sapiens_hsa034501.39502148
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39424310
52Homologous recombination_Homo sapiens_hsa034401.37955616
53Measles_Homo sapiens_hsa051621.37763074
54SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27968194
55RNA transport_Homo sapiens_hsa030131.27149944
56Primary immunodeficiency_Homo sapiens_hsa053401.26658707
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26528243
58Basal transcription factors_Homo sapiens_hsa030221.26105820
59Serotonergic synapse_Homo sapiens_hsa047261.25757257
60TGF-beta signaling pathway_Homo sapiens_hsa043501.23702699
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22999245
62Malaria_Homo sapiens_hsa051441.18764778
63African trypanosomiasis_Homo sapiens_hsa051431.17658693
64Morphine addiction_Homo sapiens_hsa050321.16898625
65Viral carcinogenesis_Homo sapiens_hsa052031.16311244
66Apoptosis_Homo sapiens_hsa042101.16137366
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15493627
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15308030
69Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14642863
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12540940
71Renal cell carcinoma_Homo sapiens_hsa052111.11750800
72Leishmaniasis_Homo sapiens_hsa051401.10809534
73Chronic myeloid leukemia_Homo sapiens_hsa052201.08183097
74Other glycan degradation_Homo sapiens_hsa005111.08083285
75TNF signaling pathway_Homo sapiens_hsa046681.03320798
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02337308
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02336423
78Type I diabetes mellitus_Homo sapiens_hsa049401.01238934
79Systemic lupus erythematosus_Homo sapiens_hsa053221.00711580
80Thyroid cancer_Homo sapiens_hsa052160.98378611
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97927511
82Herpes simplex infection_Homo sapiens_hsa051680.97051870
83N-Glycan biosynthesis_Homo sapiens_hsa005100.95605008
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.94991801
85Glutamatergic synapse_Homo sapiens_hsa047240.91943041
86Influenza A_Homo sapiens_hsa051640.91743664
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.89618404
88Linoleic acid metabolism_Homo sapiens_hsa005910.87538652
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86451103
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85743751
91Osteoclast differentiation_Homo sapiens_hsa043800.85111453
92Pathways in cancer_Homo sapiens_hsa052000.84785817
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82473872
94Chemokine signaling pathway_Homo sapiens_hsa040620.81778245
95Ovarian steroidogenesis_Homo sapiens_hsa049130.80849859
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80352012
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80261980
98Calcium signaling pathway_Homo sapiens_hsa040200.80065959
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77117451
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75325483
101Glioma_Homo sapiens_hsa052140.75273302
102Amoebiasis_Homo sapiens_hsa051460.75094046
103Epstein-Barr virus infection_Homo sapiens_hsa051690.71599910
104Pertussis_Homo sapiens_hsa051330.71079087
105Axon guidance_Homo sapiens_hsa043600.70786919
106Vitamin digestion and absorption_Homo sapiens_hsa049770.67785696
107Phagosome_Homo sapiens_hsa041450.66563586
108Tight junction_Homo sapiens_hsa045300.66297032
109Tuberculosis_Homo sapiens_hsa051520.65714148
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.64803652
111Protein export_Homo sapiens_hsa030600.63300330
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.62692645
113Legionellosis_Homo sapiens_hsa051340.61313052
114Ras signaling pathway_Homo sapiens_hsa040140.61136298
115mRNA surveillance pathway_Homo sapiens_hsa030150.59886882
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.59736697
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58122205
118Staphylococcus aureus infection_Homo sapiens_hsa051500.57080518
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.56235017
120Olfactory transduction_Homo sapiens_hsa047400.55956119
121HTLV-I infection_Homo sapiens_hsa051660.55050313
122Dorso-ventral axis formation_Homo sapiens_hsa043200.54786214
123Melanoma_Homo sapiens_hsa052180.54361478
124Circadian entrainment_Homo sapiens_hsa047130.53501843
125Hepatitis C_Homo sapiens_hsa051600.53144859
126Collecting duct acid secretion_Homo sapiens_hsa049660.52190088
127VEGF signaling pathway_Homo sapiens_hsa043700.52030447
128Mineral absorption_Homo sapiens_hsa049780.51236345
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50450991
130Base excision repair_Homo sapiens_hsa034100.50008546
131Alcoholism_Homo sapiens_hsa050340.48531314
132Prostate cancer_Homo sapiens_hsa052150.47820463
133Inositol phosphate metabolism_Homo sapiens_hsa005620.47281247
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.46858001
135Salmonella infection_Homo sapiens_hsa051320.46768848
136T cell receptor signaling pathway_Homo sapiens_hsa046600.46111762
137Arginine biosynthesis_Homo sapiens_hsa002200.46033460
138cAMP signaling pathway_Homo sapiens_hsa040240.45702138
139Wnt signaling pathway_Homo sapiens_hsa043100.45655968
140Toxoplasmosis_Homo sapiens_hsa051450.44486257
141Circadian rhythm_Homo sapiens_hsa047100.44425440
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.44380611
143GABAergic synapse_Homo sapiens_hsa047270.44211897
144Regulation of autophagy_Homo sapiens_hsa041400.42626927
145Steroid biosynthesis_Homo sapiens_hsa001000.41450083
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41436223
147Cholinergic synapse_Homo sapiens_hsa047250.40947499
148Endocytosis_Homo sapiens_hsa041440.40826517
149Salivary secretion_Homo sapiens_hsa049700.40320017
150Long-term depression_Homo sapiens_hsa047300.40284446
151MAPK signaling pathway_Homo sapiens_hsa040100.38853654
152Hepatitis B_Homo sapiens_hsa051610.38852252
153Choline metabolism in cancer_Homo sapiens_hsa052310.37855520
154ABC transporters_Homo sapiens_hsa020100.37365805
155Basal cell carcinoma_Homo sapiens_hsa052170.37335160
156Leukocyte transendothelial migration_Homo sapiens_hsa046700.37037903
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36945173
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36242353
159Drug metabolism - other enzymes_Homo sapiens_hsa009830.36221507
160ErbB signaling pathway_Homo sapiens_hsa040120.36089101
161Viral myocarditis_Homo sapiens_hsa054160.35903247
162Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35797126
163RNA polymerase_Homo sapiens_hsa030200.35439102
164Oocyte meiosis_Homo sapiens_hsa041140.34710802
165Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34560023
166Retinol metabolism_Homo sapiens_hsa008300.33660343

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