ARMCX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.23090290
2synaptic vesicle exocytosis (GO:0016079)4.67247703
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.55568427
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.38128066
5regulation of synaptic vesicle exocytosis (GO:2000300)4.34989378
6synaptic vesicle maturation (GO:0016188)4.15061195
7vocalization behavior (GO:0071625)4.09755155
8nucleobase catabolic process (GO:0046113)4.08650436
9glutamate secretion (GO:0014047)4.05756481
10locomotory exploration behavior (GO:0035641)3.99817862
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.93821443
12protein localization to synapse (GO:0035418)3.88928913
13neuronal action potential propagation (GO:0019227)3.88796201
14neuron cell-cell adhesion (GO:0007158)3.78257246
15regulation of synaptic vesicle transport (GO:1902803)3.74639634
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.69738614
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.66526142
18regulation of glutamate receptor signaling pathway (GO:1900449)3.53402370
19neurotransmitter secretion (GO:0007269)3.51008015
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46961771
21exploration behavior (GO:0035640)3.35079398
22Golgi transport vesicle coating (GO:0048200)3.30976535
23COPI coating of Golgi vesicle (GO:0048205)3.30976535
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.24864519
25activation of protein kinase A activity (GO:0034199)3.24403019
26detection of calcium ion (GO:0005513)3.24186505
27neuron recognition (GO:0008038)3.23164665
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22179705
29regulation of neuronal synaptic plasticity (GO:0048168)3.21337788
30regulation of synapse structural plasticity (GO:0051823)3.18115223
31innervation (GO:0060384)3.17833234
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.17621370
33neuron-neuron synaptic transmission (GO:0007270)3.15631789
34synaptic transmission, glutamatergic (GO:0035249)3.11940846
35vesicle transport along microtubule (GO:0047496)3.07141183
36proline transport (GO:0015824)3.05195842
37regulation of axon guidance (GO:1902667)3.05130371
38axonal fasciculation (GO:0007413)3.04242448
39glutamate receptor signaling pathway (GO:0007215)3.01581484
40long-term synaptic potentiation (GO:0060291)2.97925881
41regulation of vesicle fusion (GO:0031338)2.97836041
42axon extension (GO:0048675)2.97168805
43layer formation in cerebral cortex (GO:0021819)2.95408185
44neurotransmitter-gated ion channel clustering (GO:0072578)2.94522737
45postsynaptic membrane organization (GO:0001941)2.93960866
46gamma-aminobutyric acid signaling pathway (GO:0007214)2.91068700
47positive regulation of synaptic transmission, GABAergic (GO:0032230)2.82704480
48positive regulation of vesicle fusion (GO:0031340)2.82401789
49regulation of neurotransmitter secretion (GO:0046928)2.81760086
50dendritic spine morphogenesis (GO:0060997)2.81117430
51presynaptic membrane assembly (GO:0097105)2.80848309
52regulation of axon extension involved in axon guidance (GO:0048841)2.80833579
53positive regulation of synapse maturation (GO:0090129)2.80696674
54regulation of excitatory postsynaptic membrane potential (GO:0060079)2.79867968
55negative regulation of axon guidance (GO:1902668)2.78356985
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.78088690
57membrane depolarization during action potential (GO:0086010)2.77639089
58neurotransmitter transport (GO:0006836)2.77538386
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.77063371
60axon extension involved in axon guidance (GO:0048846)2.77010016
61neuron projection extension involved in neuron projection guidance (GO:1902284)2.77010016
62negative chemotaxis (GO:0050919)2.76881874
63regulation of synaptic plasticity (GO:0048167)2.76159368
64long-term memory (GO:0007616)2.74307962
65auditory behavior (GO:0031223)2.74207790
66negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73096797
67cerebellar Purkinje cell layer development (GO:0021680)2.72696871
68regulation of cAMP-dependent protein kinase activity (GO:2000479)2.72027768
69cerebellar Purkinje cell differentiation (GO:0021702)2.71602600
70dendrite morphogenesis (GO:0048813)2.71411022
71positive regulation of synapse assembly (GO:0051965)2.70988513
72calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.69972083
73regulation of postsynaptic membrane potential (GO:0060078)2.69499596
74synaptic vesicle endocytosis (GO:0048488)2.69347159
75regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.66893023
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66204737
77regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.65528853
78gamma-aminobutyric acid transport (GO:0015812)2.63699790
79regulation of synaptic transmission, glutamatergic (GO:0051966)2.63699677
80cellular potassium ion homeostasis (GO:0030007)2.63582111
81protein maturation by protein folding (GO:0022417)2.63361232
82organelle transport along microtubule (GO:0072384)2.61957299
83presynaptic membrane organization (GO:0097090)2.61747442
84synapse assembly (GO:0007416)2.61745329
85positive regulation of membrane potential (GO:0045838)2.60895730
86negative regulation of protein localization to cell surface (GO:2000009)2.60594328
87cell communication by electrical coupling (GO:0010644)2.60004469
88regulation of neurotransmitter transport (GO:0051588)2.59961546
89establishment of mitochondrion localization (GO:0051654)2.59488492
90negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.59390401
91central nervous system projection neuron axonogenesis (GO:0021952)2.57601090
92synaptic vesicle transport (GO:0048489)2.55849303
93establishment of synaptic vesicle localization (GO:0097480)2.55849303
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.54052214
95neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.53900660
96regulation of dendritic spine morphogenesis (GO:0061001)2.53274137
97startle response (GO:0001964)2.50943139
98synapse organization (GO:0050808)2.50559919
99regulation of neurotransmitter levels (GO:0001505)2.49965589
100maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49946065
101membrane depolarization (GO:0051899)2.49356559
102ATP hydrolysis coupled proton transport (GO:0015991)2.48868524
103energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.48868524
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.48836156
105membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.47821956
106membrane assembly (GO:0071709)2.47802559
107cell migration in hindbrain (GO:0021535)2.47683829
108synaptic transmission (GO:0007268)2.46955048
109regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.46560742
110retinal ganglion cell axon guidance (GO:0031290)2.45293959
111establishment of vesicle localization (GO:0051650)2.45136504
112dendritic spine organization (GO:0097061)2.44202491
113neuron projection extension (GO:1990138)2.43551237
114positive regulation of neurotransmitter transport (GO:0051590)2.43417270
115neuromuscular process controlling posture (GO:0050884)2.43404386
116positive regulation of synaptic transmission (GO:0050806)2.42682348
117neuromuscular process controlling balance (GO:0050885)2.42201891
118nerve growth factor signaling pathway (GO:0038180)2.42198941
119regulation of synaptic transmission, GABAergic (GO:0032228)2.42101567
120regulation of synapse assembly (GO:0051963)2.41690814
121negative regulation of dendrite morphogenesis (GO:0050774)2.40768150
122regulation of amyloid precursor protein catabolic process (GO:1902991)2.40514610
123regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.40362644
124positive regulation of potassium ion transport (GO:0043268)2.40207303
125cerebral cortex radially oriented cell migration (GO:0021799)2.39901452
126neuronal ion channel clustering (GO:0045161)2.38080798
127protein heterotrimerization (GO:0070208)2.35484037
128negative regulation of oligodendrocyte differentiation (GO:0048715)2.34702766
129glycosphingolipid biosynthetic process (GO:0006688)2.34009815
130negative regulation of axon extension involved in axon guidance (GO:0048843)2.31912689
131mating behavior (GO:0007617)2.25778491
132positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.24620822
133regulation of cell communication by electrical coupling (GO:0010649)2.21418046
134ganglion development (GO:0061548)2.19366858
135transmission of nerve impulse (GO:0019226)2.18652649
136sequestering of actin monomers (GO:0042989)2.17755124
137negative regulation of axon extension (GO:0030517)2.17683019
138neuromuscular synaptic transmission (GO:0007274)2.15590267
139establishment of nucleus localization (GO:0040023)2.14593280
140negative regulation of neurotransmitter transport (GO:0051589)2.12783498
141hippocampus development (GO:0021766)2.12195881
142collagen fibril organization (GO:0030199)2.12065571
143positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.11561277
144regulation of integrin-mediated signaling pathway (GO:2001044)2.11108521
145cell communication involved in cardiac conduction (GO:0086065)2.10864936
146homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.10719867
147response to auditory stimulus (GO:0010996)2.10719516
148central nervous system neuron axonogenesis (GO:0021955)2.10272102
149regulation of axon extension (GO:0030516)2.09871157
150heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.09833069
151positive regulation of axon extension (GO:0045773)2.09190984
152cardiac ventricle formation (GO:0003211)2.09022235
153limb bud formation (GO:0060174)2.08425469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.82271990
2GBX2_23144817_ChIP-Seq_PC3_Human3.75862409
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12609817
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10917442
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92235148
6SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.73523756
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68589293
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63831924
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63831924
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63501958
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57072737
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.53406858
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47370640
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46965851
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.45292597
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40316666
17REST_21632747_ChIP-Seq_MESCs_Mouse2.19093985
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10021005
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.09545422
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.07805909
21* RARB_27405468_Chip-Seq_BRAIN_Mouse1.97152101
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97012096
23TAF15_26573619_Chip-Seq_HEK293_Human1.91952289
24DROSHA_22980978_ChIP-Seq_HELA_Human1.86758697
25ZNF274_21170338_ChIP-Seq_K562_Hela1.83028615
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.81505335
27SMAD4_21799915_ChIP-Seq_A2780_Human1.79742856
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77202178
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74204610
30AR_21572438_ChIP-Seq_LNCaP_Human1.72366293
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71289592
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69464667
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66251193
34NR3C1_23031785_ChIP-Seq_PC12_Mouse1.63433134
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61993437
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61978246
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59913636
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58858192
39P300_19829295_ChIP-Seq_ESCs_Human1.58391102
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52631351
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47087350
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.46507889
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46284943
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45540292
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43862942
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43210654
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41696776
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36815842
49IGF1R_20145208_ChIP-Seq_DFB_Human1.36357573
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.36240451
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35056922
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34252082
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34206814
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.33973844
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30892830
56AR_25329375_ChIP-Seq_VCAP_Human1.30558758
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30124548
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.28323972
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28234826
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.26853084
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.24660187
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23994982
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23101685
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22610712
65TP53_18474530_ChIP-ChIP_U2OS_Human1.21498589
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20879327
67STAT3_23295773_ChIP-Seq_U87_Human1.20481908
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.20010909
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.19878617
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19361829
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19097708
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.18378827
73AR_19668381_ChIP-Seq_PC3_Human1.17543746
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.16580257
75* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15777688
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15733611
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15555745
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14326817
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13952006
80* WT1_19549856_ChIP-ChIP_CCG9911_Human1.13605139
81VDR_22108803_ChIP-Seq_LS180_Human1.13037309
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.12440029
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12000519
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11695108
85EWS_26573619_Chip-Seq_HEK293_Human1.10356785
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08850039
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08850039
88TCF4_23295773_ChIP-Seq_U87_Human1.08408578
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.05938237
90CJUN_26792858_Chip-Seq_BT549_Human1.05669214
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05600772
92FUS_26573619_Chip-Seq_HEK293_Human1.04625570
93RNF2_27304074_Chip-Seq_NSC_Mouse1.03039143
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.02698922
95AHR_22903824_ChIP-Seq_MCF-7_Human1.02444784
96RUNX2_22187159_ChIP-Seq_PCA_Human1.01889522
97P53_22387025_ChIP-Seq_ESCs_Mouse1.01648291
98BCAT_22108803_ChIP-Seq_LS180_Human1.01206576
99KDM2B_26808549_Chip-Seq_REH_Human1.01201804
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01132699
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00299348
102JUN_21703547_ChIP-Seq_K562_Human0.99535472
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99400559
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98623050
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98486635
106ER_23166858_ChIP-Seq_MCF-7_Human0.98440801
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97955757
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97479394
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96956535
110TAL1_26923725_Chip-Seq_HPCs_Mouse0.96805813
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.96797376
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96020848
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95567460
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94966803
115P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94737405
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.94670882
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92616092
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92067940
119OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90027043
120TP53_16413492_ChIP-PET_HCT116_Human0.89881198
121GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88820060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.65046117
2MP0003880_abnormal_central_pattern3.64742570
3MP0004270_analgesia3.29998451
4MP0003635_abnormal_synaptic_transmissio3.24554498
5MP0009780_abnormal_chondrocyte_physiolo2.89710901
6MP0001968_abnormal_touch/_nociception2.79226802
7MP0003122_maternal_imprinting2.69532428
8MP0009745_abnormal_behavioral_response2.63296206
9MP0002063_abnormal_learning/memory/cond2.56990334
10MP0000013_abnormal_adipose_tissue2.55639747
11MP0002734_abnormal_mechanical_nocicepti2.54857391
12MP0002064_seizures2.53198411
13MP0002736_abnormal_nociception_after2.45886039
14MP0002735_abnormal_chemical_nociception2.42740271
15MP0009046_muscle_twitch2.35853360
16MP0002909_abnormal_adrenal_gland2.25970807
17MP0002572_abnormal_emotion/affect_behav2.23296922
18MP0002272_abnormal_nervous_system2.22742383
19MP0002733_abnormal_thermal_nociception1.99682750
20MP0010386_abnormal_urinary_bladder1.95092388
21MP0006276_abnormal_autonomic_nervous1.89861355
22MP0001970_abnormal_pain_threshold1.89246148
23MP0002837_dystrophic_cardiac_calcinosis1.85198342
24MP0001501_abnormal_sleep_pattern1.80113629
25MP0001486_abnormal_startle_reflex1.78680694
26MP0002184_abnormal_innervation1.77584241
27MP0004858_abnormal_nervous_system1.72419668
28MP0005187_abnormal_penis_morphology1.70720854
29MP0002067_abnormal_sensory_capabilities1.67191283
30MP0010368_abnormal_lymphatic_system1.61207775
31MP0001879_abnormal_lymphatic_vessel1.58738173
32MP0005646_abnormal_pituitary_gland1.56943849
33MP0000751_myopathy1.56314870
34MP0001440_abnormal_grooming_behavior1.54557071
35MP0004811_abnormal_neuron_physiology1.53067913
36MP0005423_abnormal_somatic_nervous1.52304244
37MP0004084_abnormal_cardiac_muscle1.50389115
38MP0000778_abnormal_nervous_system1.50205009
39MP0006054_spinal_hemorrhage1.47492356
40MP0002102_abnormal_ear_morphology1.46880809
41MP0000955_abnormal_spinal_cord1.45749393
42MP0002822_catalepsy1.42775947
43MP0002557_abnormal_social/conspecific_i1.39238296
44MP0003183_abnormal_peptide_metabolism1.38388285
45MP0008569_lethality_at_weaning1.37693507
46MP0004145_abnormal_muscle_electrophysio1.36950365
47MP0008438_abnormal_cutaneous_collagen1.35605091
48MP0001958_emphysema1.35454885
49MP0005394_taste/olfaction_phenotype1.35444067
50MP0005499_abnormal_olfactory_system1.35444067
51MP0003787_abnormal_imprinting1.35218206
52MP0003329_amyloid_beta_deposits1.32909492
53MP0005645_abnormal_hypothalamus_physiol1.32147238
54MP0003879_abnormal_hair_cell1.32044337
55MP0003279_aneurysm1.29676161
56MP0003283_abnormal_digestive_organ1.28716379
57MP0002751_abnormal_autonomic_nervous1.25632299
58MP0001299_abnormal_eye_distance/1.25272860
59MP0004924_abnormal_behavior1.24469943
60MP0005386_behavior/neurological_phenoty1.24469943
61MP0005503_abnormal_tendon_morphology1.21159480
62MP0002295_abnormal_pulmonary_circulatio1.21048653
63MP0002882_abnormal_neuron_morphology1.20408323
64MP0008789_abnormal_olfactory_epithelium1.19837127
65MP0005171_absent_coat_pigmentation1.13149495
66MP0002066_abnormal_motor_capabilities/c1.12088099
67MP0004233_abnormal_muscle_weight1.10567058
68MP0001188_hyperpigmentation1.10212144
69MP0004085_abnormal_heartbeat1.09466142
70MP0001502_abnormal_circadian_rhythm1.08518269
71MP0001984_abnormal_olfaction1.05579228
72MP0003633_abnormal_nervous_system1.04844196
73MP0002653_abnormal_ependyma_morphology1.04437242
74MP0004043_abnormal_pH_regulation1.03299241
75MP0005248_abnormal_Harderian_gland1.03145736
76MP0003942_abnormal_urinary_system1.02183760
77MP0005257_abnormal_intraocular_pressure0.99335852
78MP0004215_abnormal_myocardial_fiber0.97798895
79MP0001944_abnormal_pancreas_morphology0.94182542
80MP0009384_cardiac_valve_regurgitation0.94060929
81MP0000003_abnormal_adipose_tissue0.92254775
82MP0001542_abnormal_bone_strength0.91253214
83MP0000049_abnormal_middle_ear0.90282437
84MP0002638_abnormal_pupillary_reflex0.89877436
85MP0003634_abnormal_glial_cell0.88786857
86MP0005379_endocrine/exocrine_gland_phen0.88744976
87MP0002693_abnormal_pancreas_physiology0.88339535
88MP0008775_abnormal_heart_ventricle0.88126653
89MP0002752_abnormal_somatic_nervous0.86218911
90MP0001177_atelectasis0.85905463
91MP0000631_abnormal_neuroendocrine_gland0.85445499
92MP0002233_abnormal_nose_morphology0.84269220
93MP0001905_abnormal_dopamine_level0.84118831
94MP0003121_genomic_imprinting0.83378335
95MP0003137_abnormal_impulse_conducting0.83106594
96MP0004142_abnormal_muscle_tone0.82982282
97MP0001529_abnormal_vocalization0.82793702
98MP0002896_abnormal_bone_mineralization0.82376040
99MP0003631_nervous_system_phenotype0.81761085
100MP0005623_abnormal_meninges_morphology0.81649483
101MP0008961_abnormal_basal_metabolism0.81013190
102MP0002152_abnormal_brain_morphology0.80228061
103MP0005275_abnormal_skin_tensile0.79854752
104MP0004036_abnormal_muscle_relaxation0.78722539
105MP0004885_abnormal_endolymph0.78264520
106MP0001664_abnormal_digestion0.78065580
107MP0002877_abnormal_melanocyte_morpholog0.77845944
108MP0000026_abnormal_inner_ear0.77836674
109MP0003755_abnormal_palate_morphology0.77001197
110MP0009250_abnormal_appendicular_skeleto0.76387786
111MP0002229_neurodegeneration0.74141974
112MP0002069_abnormal_eating/drinking_beha0.74011965
113MP0005508_abnormal_skeleton_morphology0.73672521
114MP0005253_abnormal_eye_physiology0.72905052
115MP0005535_abnormal_body_temperature0.70297902
116MP0002876_abnormal_thyroid_physiology0.70132402
117MP0002234_abnormal_pharynx_morphology0.69927638
118MP0001986_abnormal_taste_sensitivity0.69878870
119MP0000749_muscle_degeneration0.69722332
120MP0002108_abnormal_muscle_morphology0.69383645
121MP0002090_abnormal_vision0.69347988
122MP0004484_altered_response_of0.66614648
123MP0000534_abnormal_ureter_morphology0.66215583
124MP0005620_abnormal_muscle_contractility0.65895460
125MP0002972_abnormal_cardiac_muscle0.64287571
126MP0001963_abnormal_hearing_physiology0.63705428
127MP0001943_abnormal_respiration0.63002050
128MP0003385_abnormal_body_wall0.62966856
129MP0005551_abnormal_eye_electrophysiolog0.62833412
130MP0004272_abnormal_basement_membrane0.62544371

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.49084834
2Myokymia (HP:0002411)4.51970494
3Atonic seizures (HP:0010819)4.36388341
4Focal seizures (HP:0007359)4.16552108
5Visual hallucinations (HP:0002367)4.11313918
6Epileptic encephalopathy (HP:0200134)3.65646605
7Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.48618709
8Febrile seizures (HP:0002373)3.44971107
9Absence seizures (HP:0002121)3.42849587
10Pheochromocytoma (HP:0002666)3.27599819
11Action tremor (HP:0002345)3.10761538
12Generalized tonic-clonic seizures (HP:0002069)3.09714012
13Premature rupture of membranes (HP:0001788)3.08519897
14Polyphagia (HP:0002591)3.04563189
15Dialeptic seizures (HP:0011146)3.02190318
16Progressive cerebellar ataxia (HP:0002073)2.96626716
17Neuroendocrine neoplasm (HP:0100634)2.96266463
18Agitation (HP:0000713)2.89809805
19Vascular tortuosity (HP:0004948)2.85964604
20Supranuclear gaze palsy (HP:0000605)2.74483946
21Depression (HP:0000716)2.69019235
22Arterial tortuosity (HP:0005116)2.68891639
23Anxiety (HP:0000739)2.67593175
24Hypoventilation (HP:0002791)2.60095733
25Papilledema (HP:0001085)2.60063277
26Epileptiform EEG discharges (HP:0011182)2.59669378
27Ankle clonus (HP:0011448)2.58207843
28Truncal ataxia (HP:0002078)2.57681436
29Aortic dissection (HP:0002647)2.54203504
30Failure to thrive in infancy (HP:0001531)2.50075062
31EEG with generalized epileptiform discharges (HP:0011198)2.46454250
32Hyperventilation (HP:0002883)2.45324022
33Congenital primary aphakia (HP:0007707)2.43353600
34Amblyopia (HP:0000646)2.39375505
35Neonatal short-limb short stature (HP:0008921)2.36735469
36Soft skin (HP:0000977)2.35953455
37Nephrogenic diabetes insipidus (HP:0009806)2.34470657
38Hypsarrhythmia (HP:0002521)2.34090269
39Cortical dysplasia (HP:0002539)2.30399835
40Abnormality of calcium-phosphate metabolism (HP:0100530)2.29101570
41Bladder diverticulum (HP:0000015)2.27628442
42Abnormality of the musculature of the pelvis (HP:0001469)2.22790386
43Abnormality of the hip-girdle musculature (HP:0001445)2.22790386
44Drooling (HP:0002307)2.20888683
45Excessive salivation (HP:0003781)2.20888683
46Limb dystonia (HP:0002451)2.20836606
47Neoplasm of the peripheral nervous system (HP:0100007)2.19245672
48Medial flaring of the eyebrow (HP:0010747)2.18722669
49Buphthalmos (HP:0000557)2.18574820
50Poor eye contact (HP:0000817)2.17566434
51Abnormality of dentin (HP:0010299)2.17140347
52Broad-based gait (HP:0002136)2.15550193
53Genital tract atresia (HP:0001827)2.13533217
54Termporal pattern (HP:0011008)2.12714190
55Insidious onset (HP:0003587)2.12714190
56Limb-girdle muscle weakness (HP:0003325)2.12306176
57Limb-girdle muscle atrophy (HP:0003797)2.11575514
58Atrophic scars (HP:0001075)2.10534744
59Papillary thyroid carcinoma (HP:0002895)2.10304584
60Torticollis (HP:0000473)2.09740118
61Menstrual irregularities (HP:0000858)2.09410501
62Vaginal atresia (HP:0000148)2.08722764
63Hypothermia (HP:0002045)2.08016722
64Abnormality of the ischium (HP:0003174)2.07533707
65Abnormality of the lower motor neuron (HP:0002366)2.06929706
66Left ventricular hypertrophy (HP:0001712)2.06708686
67Exercise-induced muscle cramps (HP:0003710)2.05555716
68Hammertoe (HP:0001765)2.05097186
69Infantile muscular hypotonia (HP:0008947)2.04397202
70Type 1 muscle fiber predominance (HP:0003803)2.04011947
71Abnormal eating behavior (HP:0100738)2.03777788
72Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.03322958
73Impaired vibration sensation in the lower limbs (HP:0002166)2.03081053
74Abnormality of pain sensation (HP:0010832)2.01540206
75Impaired pain sensation (HP:0007328)2.01540206
76Prolonged QT interval (HP:0001657)2.01454103
77Megalencephaly (HP:0001355)1.98082401
78Resting tremor (HP:0002322)1.97449552
79Impaired social interactions (HP:0000735)1.97029095
80Abnormal social behavior (HP:0012433)1.97029095
81Progressive inability to walk (HP:0002505)1.95672105
82Neoplasm of the heart (HP:0100544)1.95381853
83Morphological abnormality of the middle ear (HP:0008609)1.93015099
84Aortic aneurysm (HP:0004942)1.92836284
85Thyroid carcinoma (HP:0002890)1.92290122
86Follicular hyperkeratosis (HP:0007502)1.91692390
87Focal dystonia (HP:0004373)1.91283981
88Postural tremor (HP:0002174)1.90955342
89Scanning speech (HP:0002168)1.90775080
90Hemiparesis (HP:0001269)1.90191525
91Pachygyria (HP:0001302)1.89656901
92Steppage gait (HP:0003376)1.88127995
93Congenital glaucoma (HP:0001087)1.87796780
94Split foot (HP:0001839)1.87691302
95Aplasia/Hypoplasia of the lens (HP:0008063)1.85033060
96Increased variability in muscle fiber diameter (HP:0003557)1.84708229
97Keratoconus (HP:0000563)1.84632621
98Increased corneal curvature (HP:0100692)1.84632621
99Specific learning disability (HP:0001328)1.83365158
100Hypercortisolism (HP:0001578)1.82375607
101Wide anterior fontanel (HP:0000260)1.81807714
102Heterochromia iridis (HP:0001100)1.81392965
103Abnormal hair whorl (HP:0010721)1.80708441
104Hyperthyroidism (HP:0000836)1.80020500
105Bradycardia (HP:0001662)1.79711249
106Spinal canal stenosis (HP:0003416)1.79533427
107Dysdiadochokinesis (HP:0002075)1.78759065
108Calf muscle hypertrophy (HP:0008981)1.77518384
109Gaze-evoked nystagmus (HP:0000640)1.75837890
110Cerebral inclusion bodies (HP:0100314)1.75242509
111Abnormality of the corticospinal tract (HP:0002492)1.74638484
112Urinary urgency (HP:0000012)1.74197536
113Dysmetria (HP:0001310)1.72548712
114Craniofacial dystonia (HP:0012179)1.72504077
115Gait imbalance (HP:0002141)1.72358197
116Mitral stenosis (HP:0001718)1.72105368
117Delayed gross motor development (HP:0002194)1.71908326
118Bowel diverticulosis (HP:0005222)1.71667792
119Spinal rigidity (HP:0003306)1.71306458
120Fetal akinesia sequence (HP:0001989)1.70510713
121Myotonia (HP:0002486)1.70392957
122Sudden death (HP:0001699)1.70151096
123Arthropathy (HP:0003040)1.69493620
124Vitreoretinal degeneration (HP:0000655)1.69006322
125Mildly elevated creatine phosphokinase (HP:0008180)1.68978372
126Narrow nasal bridge (HP:0000446)1.68310232
127Lower limb asymmetry (HP:0100559)1.67990487
128Hypoplasia of the iris (HP:0007676)1.67859204
129Ulnar claw (HP:0001178)1.67831836
130Absent speech (HP:0001344)1.67546085
131Psychosis (HP:0000709)1.67438610
132Atrial fibrillation (HP:0005110)1.66528334
133Decreased circulating renin level (HP:0003351)1.66348495
134Aplasia/Hypoplasia of the brainstem (HP:0007362)1.66308025
135Hypoplasia of the brainstem (HP:0002365)1.66308025
136Overgrowth (HP:0001548)1.66170972
137Macroorchidism (HP:0000053)1.66143333
138Hypoplastic ischia (HP:0003175)1.65699799
139Akinesia (HP:0002304)1.65673653
140Pulmonary artery stenosis (HP:0004415)1.64870200
141Exotropia (HP:0000577)1.64427283
142Shoulder girdle muscle weakness (HP:0003547)1.63984839
143Protrusio acetabuli (HP:0003179)1.63200996
144Short foot (HP:0001773)1.62931137
145Distal arthrogryposis (HP:0005684)1.62818563
146Type II lissencephaly (HP:0007260)1.62179643
147Spastic gait (HP:0002064)1.60814155
148Lower limb muscle weakness (HP:0007340)1.60734679
149Neurofibrillary tangles (HP:0002185)1.60480437
150Abnormality of the calf musculature (HP:0001430)1.60462660
151Abnormality of binocular vision (HP:0011514)1.60403369
152Diplopia (HP:0000651)1.60403369
153Gait ataxia (HP:0002066)1.59875008
154Impaired smooth pursuit (HP:0007772)1.59554462
155Abnormal EKG (HP:0003115)1.58791697
156Retinal dysplasia (HP:0007973)1.58309008
157Stereotypic behavior (HP:0000733)1.57494952
158Exercise-induced myalgia (HP:0003738)1.56409522

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.27734282
2EPHA43.12554325
3MAP3K92.75605458
4MAP3K42.68364386
5MINK12.65551648
6CASK2.54723002
7MAP2K72.53471667
8NTRK12.36598223
9PINK12.17179304
10MARK12.13790693
11PLK22.02594298
12MAP3K121.99012065
13TRIM281.94887960
14EPHB21.94591774
15PRKD31.92869616
16MAP4K21.83251813
17MAP3K21.79572856
18RIPK41.78821450
19MAP2K41.73035400
20KSR21.68103882
21FRK1.67778925
22CAMKK21.66564060
23DAPK21.64068201
24UHMK11.54320649
25PAK61.53954992
26INSRR1.51415499
27FER1.49230485
28CAMKK11.42679399
29DYRK21.38948976
30CDK51.38336372
31GRK51.34590622
32CSNK1G31.31964497
33ARAF1.28251474
34NTRK21.27673778
35PAK31.26451626
36LIMK11.26109632
37CSNK1A1L1.23859590
38MAPK131.22776404
39CDK191.19352247
40SCYL21.18715216
41CSNK1G11.13621326
42RET1.13477813
43WNK31.13406813
44CAMK2A1.10718292
45FES1.10441045
46PDGFRA1.10019872
47PTK2B1.08199553
48DAPK11.08198134
49PRKCG1.07967560
50KSR11.06915531
51OBSCN1.05426809
52SGK4941.00342920
53SGK2231.00342920
54PRKCE0.98451828
55STK38L0.98441661
56PRKCH0.97761429
57PRPF4B0.97468549
58TIE10.96918740
59WNK40.96589763
60CAMK2B0.95991407
61CDK140.94508830
62DYRK1B0.88657417
63EPHA30.88623332
64DDR20.87429314
65MAP3K10.83712848
66SIK20.83478396
67PIK3CA0.81946113
68ERBB30.81301874
69SGK20.78161961
70CAMK2D0.77978811
71PHKG20.77585542
72PHKG10.77585542
73CDK180.77397839
74NEK90.77230210
75WNK10.76316266
76CDK150.74343670
77PNCK0.71474347
78MAP2K10.70754158
79BMPR20.70356711
80TNIK0.68888424
81MAP3K130.68859311
82NME10.68274891
83CAMK10.66095078
84DYRK1A0.65683573
85CDC42BPA0.65035926
86ADRBK20.64803973
87SIK30.63913978
88GRK70.62148583
89PKN10.61813369
90DYRK30.61719807
91LATS20.61528643
92HIPK20.61500864
93ADRBK10.61202665
94MYLK0.60964472
95CDK11A0.59152113
96PAK20.58517252
97GRK10.58300341
98FGFR20.58041398
99YES10.58007416
100OXSR10.55739647
101STK380.54084059
102LMTK20.53486689
103EPHB10.53439989
104SGK10.53150996
105AKT30.52910573
106CSNK1G20.51986216
107SGK30.51983012
108TRIB30.50593320
109CAMK2G0.50346223
110TESK10.49330550
111PKN20.48955183
112MAPK150.48639578
113LATS10.47221569
114FYN0.46943298
115STK390.46515040
116PRKD10.46286889
117RPS6KA20.46162945
118MAP3K50.46095610
119PDGFRB0.45125830
120BCKDK0.44486935
121PTK20.44164649
122ROCK20.43785972
123PRKCZ0.43622185
124NEK60.43392448
125PDPK10.42857780
126MOS0.42486801
127ROCK10.41896490
128TYRO30.41847228
129PRKG10.41043329
130ERBB20.40411615
131CSNK1D0.40197142
132BCR0.39940827
133PDK10.39204163
134RPS6KA30.39196650
135RPS6KA40.38688259

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.01029764
2Nicotine addiction_Homo sapiens_hsa050332.78155396
3GABAergic synapse_Homo sapiens_hsa047272.31154338
4Insulin secretion_Homo sapiens_hsa049112.29408987
5Long-term potentiation_Homo sapiens_hsa047202.28687679
6Circadian entrainment_Homo sapiens_hsa047132.28553989
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22885361
8Amphetamine addiction_Homo sapiens_hsa050312.22003864
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12914654
10Dopaminergic synapse_Homo sapiens_hsa047282.03229430
11Morphine addiction_Homo sapiens_hsa050321.98732037
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.97928301
13Vibrio cholerae infection_Homo sapiens_hsa051101.96356462
14Collecting duct acid secretion_Homo sapiens_hsa049661.95464372
15Glutamatergic synapse_Homo sapiens_hsa047241.93215066
16Olfactory transduction_Homo sapiens_hsa047401.92446875
17Taste transduction_Homo sapiens_hsa047421.71627107
18Cholinergic synapse_Homo sapiens_hsa047251.71172602
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66914106
20Cocaine addiction_Homo sapiens_hsa050301.64519560
21Salivary secretion_Homo sapiens_hsa049701.63835352
22Serotonergic synapse_Homo sapiens_hsa047261.60424020
23ECM-receptor interaction_Homo sapiens_hsa045121.59852302
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58161032
25Renin secretion_Homo sapiens_hsa049241.53965872
26Long-term depression_Homo sapiens_hsa047301.53231314
27Gastric acid secretion_Homo sapiens_hsa049711.51488520
28Steroid biosynthesis_Homo sapiens_hsa001001.40650951
29Oxytocin signaling pathway_Homo sapiens_hsa049211.38411580
30Pancreatic secretion_Homo sapiens_hsa049721.38279079
31Calcium signaling pathway_Homo sapiens_hsa040201.33394088
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.33358091
33Gap junction_Homo sapiens_hsa045401.28071609
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25436449
35Type II diabetes mellitus_Homo sapiens_hsa049301.23709235
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.18906240
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18502219
38GnRH signaling pathway_Homo sapiens_hsa049121.16674848
39Cardiac muscle contraction_Homo sapiens_hsa042601.15309643
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13725475
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12888724
42Protein export_Homo sapiens_hsa030601.11390965
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11231564
44Estrogen signaling pathway_Homo sapiens_hsa049151.09636635
45cAMP signaling pathway_Homo sapiens_hsa040241.08524928
46Dilated cardiomyopathy_Homo sapiens_hsa054141.07461678
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.04854153
48Glioma_Homo sapiens_hsa052141.04549174
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03529121
50Thyroid hormone synthesis_Homo sapiens_hsa049180.98352390
51Melanogenesis_Homo sapiens_hsa049160.97784437
52Axon guidance_Homo sapiens_hsa043600.95815659
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94669544
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94397763
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92991312
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92156224
57Hippo signaling pathway_Homo sapiens_hsa043900.91496182
58Hedgehog signaling pathway_Homo sapiens_hsa043400.91440581
59Oxidative phosphorylation_Homo sapiens_hsa001900.89456645
60Tight junction_Homo sapiens_hsa045300.89222960
61Type I diabetes mellitus_Homo sapiens_hsa049400.88631555
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88516409
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86842891
64Alzheimers disease_Homo sapiens_hsa050100.86244824
65Fatty acid elongation_Homo sapiens_hsa000620.83485902
66Butanoate metabolism_Homo sapiens_hsa006500.83333816
67ErbB signaling pathway_Homo sapiens_hsa040120.83058434
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81812620
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77795294
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76534900
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76463703
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75604881
73Adherens junction_Homo sapiens_hsa045200.75158174
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74889513
75Propanoate metabolism_Homo sapiens_hsa006400.73428222
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72981801
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71948959
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69975271
79Glucagon signaling pathway_Homo sapiens_hsa049220.68950899
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.67245757
81Phagosome_Homo sapiens_hsa041450.66579289
82Protein digestion and absorption_Homo sapiens_hsa049740.66489847
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65986534
84AMPK signaling pathway_Homo sapiens_hsa041520.64776560
85Parkinsons disease_Homo sapiens_hsa050120.62979870
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59858447
87Dorso-ventral axis formation_Homo sapiens_hsa043200.58795460
88Oocyte meiosis_Homo sapiens_hsa041140.58456988
89Phototransduction_Homo sapiens_hsa047440.58225300
90N-Glycan biosynthesis_Homo sapiens_hsa005100.58020029
91Amoebiasis_Homo sapiens_hsa051460.57484453
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57234088
93MAPK signaling pathway_Homo sapiens_hsa040100.56817323
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.56672872
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55970703
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55641531
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54929730
98Ras signaling pathway_Homo sapiens_hsa040140.54140374
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.53881119
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53861883
101Rap1 signaling pathway_Homo sapiens_hsa040150.53731807
102Rheumatoid arthritis_Homo sapiens_hsa053230.53546206
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51422642
104Basal cell carcinoma_Homo sapiens_hsa052170.50834826
105Regulation of autophagy_Homo sapiens_hsa041400.50614360
106Endometrial cancer_Homo sapiens_hsa052130.50307917
107mTOR signaling pathway_Homo sapiens_hsa041500.50006326
108TGF-beta signaling pathway_Homo sapiens_hsa043500.49990790
109Prion diseases_Homo sapiens_hsa050200.49623711
110beta-Alanine metabolism_Homo sapiens_hsa004100.48529026
111VEGF signaling pathway_Homo sapiens_hsa043700.47822806
112Insulin signaling pathway_Homo sapiens_hsa049100.47478956
113Circadian rhythm_Homo sapiens_hsa047100.47172209
114Renal cell carcinoma_Homo sapiens_hsa052110.46997081
115Endocytosis_Homo sapiens_hsa041440.46397743
116Choline metabolism in cancer_Homo sapiens_hsa052310.45480543
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.45329201
118Focal adhesion_Homo sapiens_hsa045100.45291801
119Proteoglycans in cancer_Homo sapiens_hsa052050.44845217
120Melanoma_Homo sapiens_hsa052180.42702480
121Ovarian steroidogenesis_Homo sapiens_hsa049130.41282391
122Lysosome_Homo sapiens_hsa041420.40794977
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40614374
124Wnt signaling pathway_Homo sapiens_hsa043100.40175657
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40162217
126Alcoholism_Homo sapiens_hsa050340.38102057

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