ARMCX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a potential N-terminal transmembrane domain and multiple armadillo (arm) repeats. Proteins containing arm repeats are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is located in a cluster of related genes on chromosome X. There is a pseudogene for this gene on chromosome 7. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)4.14821835
2synaptic vesicle maturation (GO:0016188)3.93227852
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.88015981
4regulation of short-term neuronal synaptic plasticity (GO:0048172)3.81924716
5glucocorticoid receptor signaling pathway (GO:0042921)3.66035473
6locomotory exploration behavior (GO:0035641)3.57003782
7negative regulation of microtubule polymerization (GO:0031115)3.51075470
8regulation of cell fate specification (GO:0042659)3.51028036
9convergent extension (GO:0060026)3.50324282
10regulation of gene silencing by RNA (GO:0060966)3.48461662
11regulation of posttranscriptional gene silencing (GO:0060147)3.48461662
12regulation of gene silencing by miRNA (GO:0060964)3.48461662
13axonal fasciculation (GO:0007413)3.43431645
14L-fucose catabolic process (GO:0042355)3.43090743
15fucose catabolic process (GO:0019317)3.43090743
16L-fucose metabolic process (GO:0042354)3.43090743
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.37769351
18dendritic spine morphogenesis (GO:0060997)3.35997488
19synaptic vesicle exocytosis (GO:0016079)3.34337523
20regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.33734019
21neuron recognition (GO:0008038)3.30723722
22presynaptic membrane assembly (GO:0097105)3.30337254
23cell migration in hindbrain (GO:0021535)3.27804124
24G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.25775943
25glutamate secretion (GO:0014047)3.18967912
26regulation of synaptic vesicle exocytosis (GO:2000300)3.18048865
27membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.17179423
28regulation of non-canonical Wnt signaling pathway (GO:2000050)3.17136898
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.16279313
30response to pheromone (GO:0019236)3.12178642
31exploration behavior (GO:0035640)3.09808727
32Golgi transport vesicle coating (GO:0048200)3.08569564
33COPI coating of Golgi vesicle (GO:0048205)3.08569564
34notochord development (GO:0030903)3.06901780
35vocalization behavior (GO:0071625)3.02885371
36outer ear morphogenesis (GO:0042473)3.02229114
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.01756499
38activation of protein kinase A activity (GO:0034199)3.00173352
39dendrite morphogenesis (GO:0048813)2.99709535
40negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.98552986
41glucosamine-containing compound catabolic process (GO:1901072)2.95640534
42corticosteroid receptor signaling pathway (GO:0031958)2.94990364
43lung-associated mesenchyme development (GO:0060484)2.94590284
44bone trabecula formation (GO:0060346)2.94223853
45establishment of nucleus localization (GO:0040023)2.94161417
46cerebellar Purkinje cell layer development (GO:0021680)2.94105862
47protein localization to synapse (GO:0035418)2.94068307
48anterior/posterior axis specification, embryo (GO:0008595)2.93701016
49positive regulation of catenin import into nucleus (GO:0035413)2.93248325
50neuron cell-cell adhesion (GO:0007158)2.92233895
51regulation of NFAT protein import into nucleus (GO:0051532)2.90503309
52positive regulation of SMAD protein import into nucleus (GO:0060391)2.89776983
53presynaptic membrane organization (GO:0097090)2.89467349
54mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.89402282
55negative regulation of chondrocyte differentiation (GO:0032331)2.88564331
56pre-miRNA processing (GO:0031054)2.87777396
57regulation of synaptic vesicle transport (GO:1902803)2.86906066
58regulation of cardioblast differentiation (GO:0051890)2.86586189
59regulation of synapse structural plasticity (GO:0051823)2.86123555
60innervation (GO:0060384)2.84247930
61postsynaptic membrane organization (GO:0001941)2.83226813
62chondrocyte proliferation (GO:0035988)2.80517088
63negative regulation of cell fate specification (GO:0009996)2.79655573
64membrane repolarization during action potential (GO:0086011)2.78542604
65peptidyl-arginine omega-N-methylation (GO:0035247)2.77841903
66establishment of integrated proviral latency (GO:0075713)2.77761321
67regulation of glutamate receptor signaling pathway (GO:1900449)2.77201090
68positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.74955018
69proline transport (GO:0015824)2.74268701
70negative regulation of dendrite morphogenesis (GO:0050774)2.73187215
71cell communication by electrical coupling (GO:0010644)2.71893477
72peptidyl-arginine N-methylation (GO:0035246)2.70676401
73peptidyl-arginine methylation (GO:0018216)2.70676401
74dendritic spine organization (GO:0097061)2.70591039
75cell migration involved in sprouting angiogenesis (GO:0002042)2.67501242
76positive regulation of synapse maturation (GO:0090129)2.65839547
77regulation of cAMP-dependent protein kinase activity (GO:2000479)2.64914442
78collagen fibril organization (GO:0030199)2.63171490
79Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.62458182
80negative regulation of striated muscle cell apoptotic process (GO:0010664)2.61522821
81inner ear receptor cell development (GO:0060119)2.61484889
82lateral sprouting from an epithelium (GO:0060601)2.61385797
83regulation of neuronal synaptic plasticity (GO:0048168)2.61127454
84metanephric mesenchyme development (GO:0072075)2.60262881
85ventricular cardiac muscle cell development (GO:0055015)2.60086612
86insulin-like growth factor receptor signaling pathway (GO:0048009)2.59900047
87chromatin remodeling at centromere (GO:0031055)2.59667512
88hippo signaling (GO:0035329)2.59194414
89dorsal/ventral axis specification (GO:0009950)2.58550533
90cerebellum development (GO:0021549)2.57509981
91body morphogenesis (GO:0010171)2.56269591
92neurotransmitter secretion (GO:0007269)2.56105248
93regulation of long-term neuronal synaptic plasticity (GO:0048169)2.56100205
94axon extension involved in axon guidance (GO:0048846)2.55776293
95neuron projection extension involved in neuron projection guidance (GO:1902284)2.55776293
96mesenchymal to epithelial transition (GO:0060231)2.54053710
97regulation of cell fate commitment (GO:0010453)2.53019694
98membrane repolarization (GO:0086009)2.52604693
99female gonad development (GO:0008585)2.52419848
100positive regulation of dendrite morphogenesis (GO:0050775)2.51934717
101nerve growth factor signaling pathway (GO:0038180)2.51934165
102central nervous system projection neuron axonogenesis (GO:0021952)2.50369574
103negative regulation of cell fate commitment (GO:0010454)2.50217534
104negative regulation of catenin import into nucleus (GO:0035414)2.49981397
105regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.49681660
106negative regulation of dendrite development (GO:2000171)2.48431889
107CENP-A containing nucleosome assembly (GO:0034080)2.48240489
108kidney mesenchyme development (GO:0072074)2.47244148
109regulation of mesoderm development (GO:2000380)2.47168963
110axon extension (GO:0048675)2.46394275
111L-serine metabolic process (GO:0006563)2.45619622
112regulation of establishment of planar polarity (GO:0090175)2.45208872
113non-canonical Wnt signaling pathway (GO:0035567)2.44585783
114sequestering of extracellular ligand from receptor (GO:0035581)2.43771094
115regulation of catenin import into nucleus (GO:0035412)2.43259100
116neuromuscular process controlling balance (GO:0050885)2.41579038
117regulation of dendrite morphogenesis (GO:0048814)2.40446447
118negative regulation of embryonic development (GO:0045992)2.40254532
119pyrimidine nucleobase catabolic process (GO:0006208)2.40063196
120regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.39850288
121regulation of axon extension involved in axon guidance (GO:0048841)2.39787877
122fucosylation (GO:0036065)2.39246343
123heterochromatin organization (GO:0070828)2.38714525
124protein heterotrimerization (GO:0070208)2.37718811
125polarized epithelial cell differentiation (GO:0030859)2.36859808
126cell surface receptor signaling pathway involved in heart development (GO:0061311)2.36758447
127mating behavior (GO:0007617)2.36520657
128positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.36234383
129regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.36234383
130positive regulation of cardiac muscle cell proliferation (GO:0060045)2.35806781
131regulation of cardiac muscle cell apoptotic process (GO:0010665)2.35751938
132positive regulation of synaptic transmission, GABAergic (GO:0032230)2.35158420
133vesicle transport along microtubule (GO:0047496)2.34221511
134apical protein localization (GO:0045176)2.33346637
135regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.32084099
136mesenchymal-epithelial cell signaling (GO:0060638)2.31398070
137generation of neurons (GO:0048699)2.31069249
138protein maturation by protein folding (GO:0022417)2.30779862
139embryonic foregut morphogenesis (GO:0048617)2.30682872
140regulation of potassium ion transmembrane transporter activity (GO:1901016)2.30582085
141regulation of axon guidance (GO:1902667)2.30454557
142clathrin coat assembly (GO:0048268)2.30125228
143cerebral cortex development (GO:0021987)2.29667293
144organelle transport along microtubule (GO:0072384)2.29661071
145paraxial mesoderm development (GO:0048339)2.28160651
146synaptic vesicle endocytosis (GO:0048488)2.28084146
147regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.27553724
148hippocampus development (GO:0021766)2.26944689
149regulation of gastrulation (GO:0010470)2.26895772
150cell fate commitment involved in formation of primary germ layer (GO:0060795)2.26535150
151artery development (GO:0060840)2.26452180
152synapse organization (GO:0050808)2.26170533
153positive regulation of axon extension (GO:0045773)2.25527924
154positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.25115329
155planar cell polarity pathway involved in neural tube closure (GO:0090179)2.25051507
156cerebellar Purkinje cell differentiation (GO:0021702)2.24926261
157lymphangiogenesis (GO:0001946)2.23830555
158positive regulation of fibroblast migration (GO:0010763)2.22523016
159digestive tract morphogenesis (GO:0048546)2.22253099
160cytoskeletal anchoring at plasma membrane (GO:0007016)2.21944220
161positive regulation of cardiac muscle tissue development (GO:0055025)2.21886882
162camera-type eye morphogenesis (GO:0048593)2.21687758
163cardiac left ventricle morphogenesis (GO:0003214)2.21657117
164positive regulation of cardiac muscle tissue growth (GO:0055023)2.21586579
165negative regulation of axon guidance (GO:1902668)2.20990533
166regulation of SMAD protein import into nucleus (GO:0060390)2.20912694
167cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.20780817
168cell migration involved in gastrulation (GO:0042074)2.20466558
169endothelial cell morphogenesis (GO:0001886)2.17937061
170negative regulation of axon extension involved in axon guidance (GO:0048843)2.17493044
171endodermal cell differentiation (GO:0035987)2.17360040
172histone exchange (GO:0043486)2.15670844
173regulation of cardiac muscle tissue development (GO:0055024)2.15425474
174cellular response to BMP stimulus (GO:0071773)2.14300855
175response to BMP (GO:0071772)2.14300855
176regulation of cardiac muscle cell proliferation (GO:0060043)2.11954395
177negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.11685007
178short-term memory (GO:0007614)2.11259263
179establishment of viral latency (GO:0019043)2.10153631
180negative regulation of fibroblast apoptotic process (GO:2000270)2.09059141
181positive regulation of heart growth (GO:0060421)2.08982683
182primitive streak formation (GO:0090009)2.08142954
183negative regulation of cartilage development (GO:0061037)2.07772507
184neuron projection extension (GO:1990138)2.06904116

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.64172585
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.89115959
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79493822
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.78892714
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73443069
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73443069
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.69164379
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.65705279
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63380481
10* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.53926277
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52730946
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.48173020
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41614046
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.40912207
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.40442916
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25710173
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.24320707
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.24202567
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20400390
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.19030178
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.18497492
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.15801779
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.14547863
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.13820079
25GBX2_23144817_ChIP-Seq_PC3_Human2.12131831
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.07705093
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05582021
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01527265
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99172654
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.98342893
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.97408628
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.96718712
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96389180
34ZNF274_21170338_ChIP-Seq_K562_Hela1.90136259
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89989445
36REST_21632747_ChIP-Seq_MESCs_Mouse1.87450158
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.87360137
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86156811
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80402826
40DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.77435161
41NANOG_16153702_ChIP-ChIP_HESCs_Human1.75380526
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72990582
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.71464363
44DROSHA_22980978_ChIP-Seq_HELA_Human1.70443809
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.67525233
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.65135440
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.64856378
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.64856378
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.64856378
50EWS_26573619_Chip-Seq_HEK293_Human1.64723479
51P300_19829295_ChIP-Seq_ESCs_Human1.63894858
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60127243
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.59967958
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.57178623
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55950312
56TBX3_20139965_ChIP-Seq_MESCs_Mouse1.55883653
57TBX3_20139965_ChIP-Seq_ESCs_Mouse1.55798217
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53888508
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.52506530
60KDM2B_26808549_Chip-Seq_K562_Human1.50842190
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50298124
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49988386
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49621647
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48448169
65TAF15_26573619_Chip-Seq_HEK293_Human1.47425684
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45568106
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43834387
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43149007
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37694385
70SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.34506004
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34468189
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33253378
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32355835
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.31538033
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30277173
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29300461
77POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.28564886
78SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27931683
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.27759970
80TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27633422
81SOX9_26525672_Chip-Seq_HEART_Mouse1.26693564
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25850433
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.25572905
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.24859404
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23926839
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.22545946
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21652877
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.20970932
89AR_19668381_ChIP-Seq_PC3_Human1.20895583
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19764713
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.19051008
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.18118574
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18031980
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17445009
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17317326
96AR_21572438_ChIP-Seq_LNCaP_Human1.15262312
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14174213
98MYC_18555785_ChIP-Seq_MESCs_Mouse1.14059227
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13725039
100* SOX2_21211035_ChIP-Seq_LN229_Gbm1.11518625
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.11373415
102TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.11017640
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10989021
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09741197
105* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09178167
106NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08071942
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07763832
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07689874
109KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05737077
110E2F7_22180533_ChIP-Seq_HELA_Human1.05689092
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05198048
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05064424
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04193823
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.04026251
115PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03172250
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02844284
117SMAD4_21799915_ChIP-Seq_A2780_Human1.02256849
118SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02191129
119FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02161547
120SMAD_19615063_ChIP-ChIP_OVARY_Human1.01570840
121SMAD3_21741376_ChIP-Seq_ESCs_Human1.00891320
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00550953
123FUS_26573619_Chip-Seq_HEK293_Human0.99969082
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99863441
125AR_21909140_ChIP-Seq_LNCAP_Human0.99714454
126BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99624341
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98771813
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98268005
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97703929
130TP53_18474530_ChIP-ChIP_U2OS_Human0.97195272
131RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97089483
132KDM2B_26808549_Chip-Seq_DND41_Human0.95323647
133E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94880801
134TET1_21490601_ChIP-Seq_MESCs_Mouse0.94707707
135EP300_21415370_ChIP-Seq_HL-1_Mouse0.94311910
136SOX3_22085726_ChIP-Seq_NPCs_Mouse0.92780084
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92490055
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91880568
139KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91736228
140P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90572036
141TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90547382
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89568437
143SOX2_16153702_ChIP-ChIP_HESCs_Human0.88928638
144STAT3_23295773_ChIP-Seq_U87_Human0.88818272
145IGF1R_20145208_ChIP-Seq_DFB_Human0.88149915
146NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87192945
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86574243
148RNF2_27304074_Chip-Seq_NSC_Mouse0.83968826
149DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83404677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.84971820
2MP0004859_abnormal_synaptic_plasticity3.72732111
3MP0003941_abnormal_skin_development2.91923273
4MP0003283_abnormal_digestive_organ2.47538140
5MP0003635_abnormal_synaptic_transmissio2.36052802
6MP0005623_abnormal_meninges_morphology2.29027605
7MP0004270_analgesia2.28734094
8MP0003880_abnormal_central_pattern2.27960214
9MP0009780_abnormal_chondrocyte_physiolo2.23884561
10MP0003121_genomic_imprinting2.20339358
11MP0003123_paternal_imprinting2.17043577
12MP0006054_spinal_hemorrhage2.01088172
13MP0005275_abnormal_skin_tensile1.93624721
14MP0010030_abnormal_orbit_morphology1.93558064
15MP0002063_abnormal_learning/memory/cond1.91529133
16MP0000537_abnormal_urethra_morphology1.89410157
17MP0000778_abnormal_nervous_system1.86015405
18MP0001293_anophthalmia1.83915012
19MP0003385_abnormal_body_wall1.83461658
20MP0010368_abnormal_lymphatic_system1.77485787
21MP0000569_abnormal_digit_pigmentation1.75464939
22MP0004858_abnormal_nervous_system1.70794939
23MP0004233_abnormal_muscle_weight1.70528535
24MP0002184_abnormal_innervation1.68721824
25MP0006292_abnormal_olfactory_placode1.63259002
26MP0002697_abnormal_eye_size1.56911679
27MP0005503_abnormal_tendon_morphology1.56847380
28MP0002877_abnormal_melanocyte_morpholog1.56504893
29MP0006276_abnormal_autonomic_nervous1.55802877
30MP0002734_abnormal_mechanical_nocicepti1.55671092
31MP0005257_abnormal_intraocular_pressure1.54739247
32MP0009384_cardiac_valve_regurgitation1.49968644
33MP0004811_abnormal_neuron_physiology1.49949729
34MP0003567_abnormal_fetal_cardiomyocyte1.48913220
35MP0001968_abnormal_touch/_nociception1.48693092
36MP0001299_abnormal_eye_distance/1.47204019
37MP0000955_abnormal_spinal_cord1.47088503
38MP0002751_abnormal_autonomic_nervous1.46794155
39MP0003942_abnormal_urinary_system1.43788565
40MP0009745_abnormal_behavioral_response1.43190960
41MP0000534_abnormal_ureter_morphology1.42430958
42MP0000013_abnormal_adipose_tissue1.41909182
43MP0002909_abnormal_adrenal_gland1.39163297
44MP0003119_abnormal_digestive_system1.37854686
45MP0004272_abnormal_basement_membrane1.37788392
46MP0003787_abnormal_imprinting1.34297848
47MP0002234_abnormal_pharynx_morphology1.34283309
48MP0002733_abnormal_thermal_nociception1.30989321
49MP0008438_abnormal_cutaneous_collagen1.30845629
50MP0002572_abnormal_emotion/affect_behav1.30735092
51MP0002064_seizures1.29568592
52MP0002735_abnormal_chemical_nociception1.27792159
53MP0005187_abnormal_penis_morphology1.27184071
54MP0000049_abnormal_middle_ear1.27168437
55MP0000428_abnormal_craniofacial_morphol1.24433118
56MP0003861_abnormal_nervous_system1.24389248
57MP0001177_atelectasis1.24171616
58MP0001286_abnormal_eye_development1.22716270
59MP0002653_abnormal_ependyma_morphology1.19251554
60MP0005423_abnormal_somatic_nervous1.17978425
61MP0004145_abnormal_muscle_electrophysio1.17561803
62MP0009053_abnormal_anal_canal1.16805496
63MP0000762_abnormal_tongue_morphology1.16681307
64MP0002152_abnormal_brain_morphology1.16151813
65MP0002254_reproductive_system_inflammat1.16080765
66MP0002557_abnormal_social/conspecific_i1.15202364
67MP0002085_abnormal_embryonic_tissue1.11143854
68MP0005076_abnormal_cell_differentiation1.10518969
69MP0001348_abnormal_lacrimal_gland1.10508114
70MP0000631_abnormal_neuroendocrine_gland1.10124980
71MP0001529_abnormal_vocalization1.08870959
72MP0002882_abnormal_neuron_morphology1.08358322
73MP0008932_abnormal_embryonic_tissue1.08154497
74MP0002272_abnormal_nervous_system1.07964102
75MP0001879_abnormal_lymphatic_vessel1.07521860
76MP0002938_white_spotting1.06362350
77MP0001188_hyperpigmentation1.06170014
78MP0009250_abnormal_appendicular_skeleto1.05387587
79MP0003566_abnormal_cell_adhesion1.04372865
80MP0000432_abnormal_head_morphology1.03578084
81MP0001970_abnormal_pain_threshold1.03284287
82MP0002736_abnormal_nociception_after1.02893287
83MP0001958_emphysema1.02585152
84MP0002116_abnormal_craniofacial_bone1.01903281
85MP0002111_abnormal_tail_morphology1.01185533
86MP0000566_synostosis1.00864711
87MP0002108_abnormal_muscle_morphology1.00188629
88MP0003279_aneurysm0.99894334
89MP0000462_abnormal_digestive_system0.97931988
90MP0002295_abnormal_pulmonary_circulatio0.97703306
91MP0003935_abnormal_craniofacial_develop0.97457475
92MP0001486_abnormal_startle_reflex0.96791592
93MP0004084_abnormal_cardiac_muscle0.96596157
94MP0002081_perinatal_lethality0.96056255
95MP0002932_abnormal_joint_morphology0.95986549
96MP0002092_abnormal_eye_morphology0.95835289
97MP0008961_abnormal_basal_metabolism0.95657276
98MP0004957_abnormal_blastocyst_morpholog0.95073541
99MP0002067_abnormal_sensory_capabilities0.94810611
100MP0001270_distended_abdomen0.94267190
101MP0000751_myopathy0.94241232
102MP0003136_yellow_coat_color0.93538195
103MP0003115_abnormal_respiratory_system0.91430902
104MP0008877_abnormal_DNA_methylation0.90856829
105MP0003755_abnormal_palate_morphology0.90608078
106MP0009046_muscle_twitch0.89798516
107MP0003890_abnormal_embryonic-extraembry0.89452457
108MP0002896_abnormal_bone_mineralization0.89123471
109MP0001849_ear_inflammation0.88864153
110MP0004215_abnormal_myocardial_fiber0.88693265
111MP0009703_decreased_birth_body0.86846877
112MP0002084_abnormal_developmental_patter0.85731646
113MP0000767_abnormal_smooth_muscle0.85685909
114MP0008569_lethality_at_weaning0.85153459
115MP0000579_abnormal_nail_morphology0.84650918
116MP0006072_abnormal_retinal_apoptosis0.84183621
117MP0001440_abnormal_grooming_behavior0.83655014
118MP0005386_behavior/neurological_phenoty0.82535166
119MP0004924_abnormal_behavior0.82535166
120MP0005499_abnormal_olfactory_system0.82254647
121MP0005394_taste/olfaction_phenotype0.82254647
122MP0002066_abnormal_motor_capabilities/c0.81996556
123MP0003937_abnormal_limbs/digits/tail_de0.81909533
124MP0002233_abnormal_nose_morphology0.79558080
125MP0001984_abnormal_olfaction0.78426943
126MP0002102_abnormal_ear_morphology0.78081669
127MP0004885_abnormal_endolymph0.77817684
128MP0003938_abnormal_ear_development0.77559165
129MP0009672_abnormal_birth_weight0.77206242
130MP0005367_renal/urinary_system_phenotyp0.76835163
131MP0000516_abnormal_urinary_system0.76835163
132MP0002114_abnormal_axial_skeleton0.76819792
133MP0002177_abnormal_outer_ear0.76762449
134MP0000733_abnormal_muscle_development0.76566800
135MP0005508_abnormal_skeleton_morphology0.76415301
136MP0004197_abnormal_fetal_growth/weight/0.76307742
137MP0008789_abnormal_olfactory_epithelium0.75849149
138MP0003705_abnormal_hypodermis_morpholog0.75032893
139MP0002282_abnormal_trachea_morphology0.74886089
140MP0004133_heterotaxia0.74611236
141MP0001542_abnormal_bone_strength0.74552689
142MP0005248_abnormal_Harderian_gland0.74035913

Predicted human phenotypes

RankGene SetZ-score
1Broad metatarsal (HP:0001783)3.19166373
2Pheochromocytoma (HP:0002666)3.12859157
3Septo-optic dysplasia (HP:0100842)3.10552270
4Shallow orbits (HP:0000586)2.95378705
5Renal duplication (HP:0000075)2.89329935
6Protrusio acetabuli (HP:0003179)2.76544511
7Hyperacusis (HP:0010780)2.68671861
8Coronal craniosynostosis (HP:0004440)2.66038365
9Colon cancer (HP:0003003)2.61006611
10Neuroendocrine neoplasm (HP:0100634)2.59573661
11Soft skin (HP:0000977)2.59475810
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.55836466
13Short 4th metacarpal (HP:0010044)2.55836466
14Visual hallucinations (HP:0002367)2.55200016
15Aortic dissection (HP:0002647)2.50758249
16Stenosis of the external auditory canal (HP:0000402)2.49654983
17Bifid tongue (HP:0010297)2.47320194
18Neonatal short-limb short stature (HP:0008921)2.47075109
19Bowel diverticulosis (HP:0005222)2.46721268
20Agitation (HP:0000713)2.45135488
21Abnormality of the labia minora (HP:0012880)2.42815862
22Myokymia (HP:0002411)2.39364779
23Insomnia (HP:0100785)2.39258294
24Choanal stenosis (HP:0000452)2.37803792
25Pointed chin (HP:0000307)2.36992762
26Neoplasm of the peripheral nervous system (HP:0100007)2.35480676
27Bladder diverticulum (HP:0000015)2.30923358
28Ankle contracture (HP:0006466)2.28763695
29Focal seizures (HP:0007359)2.26319238
30Focal motor seizures (HP:0011153)2.18814114
31Termporal pattern (HP:0011008)2.18657789
32Insidious onset (HP:0003587)2.18657789
33Neoplasm of the heart (HP:0100544)2.18590802
34Hypoventilation (HP:0002791)2.16886699
35Hepatoblastoma (HP:0002884)2.16496057
36Sacral dimple (HP:0000960)2.16495364
37Buphthalmos (HP:0000557)2.15316578
38Absent septum pellucidum (HP:0001331)2.14330578
39Preaxial foot polydactyly (HP:0001841)2.12460796
40Macroorchidism (HP:0000053)2.10923830
41Abnormality of the 4th metacarpal (HP:0010012)2.09369714
42Maternal diabetes (HP:0009800)2.06202470
43Vitreoretinal degeneration (HP:0000655)2.05625254
44Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04845906
45Atrophic scars (HP:0001075)2.02253555
46Neoplasm of the adrenal gland (HP:0100631)2.02252991
47Elfin facies (HP:0004428)2.01392774
48Anophthalmia (HP:0000528)2.01242979
49Papilledema (HP:0001085)2.00837355
50Overriding aorta (HP:0002623)2.00641851
51Short hallux (HP:0010109)2.00336972
52Pterygium (HP:0001059)1.99190682
53Renovascular hypertension (HP:0100817)1.99049010
54Ankle clonus (HP:0011448)1.98539822
55Vascular tortuosity (HP:0004948)1.97853172
56Abnormal lung lobation (HP:0002101)1.97748763
57Shoulder girdle muscle weakness (HP:0003547)1.97080920
58Ankyloglossia (HP:0010296)1.96257809
59Abnormality of the septum pellucidum (HP:0007375)1.96117313
60Broad long bones (HP:0005622)1.94609916
61Impaired smooth pursuit (HP:0007772)1.94217403
62Partial duplication of thumb phalanx (HP:0009944)1.92131864
63Aplasia/Hypoplasia of the hallux (HP:0008362)1.92117755
64Vertebral clefting (HP:0008428)1.91166120
65Myelomeningocele (HP:0002475)1.90370454
66Failure to thrive in infancy (HP:0001531)1.90259375
67Premature rupture of membranes (HP:0001788)1.89927248
68Flat cornea (HP:0007720)1.89800808
69Lower limb amyotrophy (HP:0007210)1.89328717
70Morphological abnormality of the middle ear (HP:0008609)1.89144421
71Partial duplication of the phalanx of hand (HP:0009999)1.88890430
72Genu recurvatum (HP:0002816)1.87253962
73Arterial tortuosity (HP:0005116)1.87092518
74Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85901109
75Hypoplasia of the brainstem (HP:0002365)1.85901109
76Abdominal situs inversus (HP:0003363)1.85794159
77Abnormality of abdominal situs (HP:0011620)1.85794159
78Limb-girdle muscle atrophy (HP:0003797)1.85761694
79Mitral valve prolapse (HP:0001634)1.84538613
80Amblyopia (HP:0000646)1.83846739
81Turricephaly (HP:0000262)1.83183050
82Calcaneovalgus deformity (HP:0001848)1.80387821
83Supranuclear gaze palsy (HP:0000605)1.80226029
84Congenital glaucoma (HP:0001087)1.78613746
85Bilateral microphthalmos (HP:0007633)1.77196244
86Cerebral aneurysm (HP:0004944)1.76822296
87Abnormality of dentin (HP:0010299)1.76421313
88Limb dystonia (HP:0002451)1.76364665
89Depression (HP:0000716)1.75943429
90Cutaneous finger syndactyly (HP:0010554)1.75885472
91Fibrous tissue neoplasm (HP:0012316)1.75585974
92Obsessive-compulsive behavior (HP:0000722)1.75373672
93Type 1 muscle fiber predominance (HP:0003803)1.74427248
94Deviation of the hallux (HP:0010051)1.74037079
95Abnormality of oral frenula (HP:0000190)1.73390770
96Atonic seizures (HP:0010819)1.72596793
97Menstrual irregularities (HP:0000858)1.72292405
98Hamartoma of the eye (HP:0010568)1.71888235
99Deformed tarsal bones (HP:0008119)1.71054320
100Action tremor (HP:0002345)1.70906498
101Spastic diplegia (HP:0001264)1.70374815
102Labial hypoplasia (HP:0000066)1.69796296
103Broad thumb (HP:0011304)1.69405525
104Cortical dysplasia (HP:0002539)1.69183104
105Limited hip movement (HP:0008800)1.69023246
106Aortic aneurysm (HP:0004942)1.68750285
107Spinal rigidity (HP:0003306)1.68209156
108Omphalocele (HP:0001539)1.67749747
109Epileptic encephalopathy (HP:0200134)1.67145415
110Ectopia lentis (HP:0001083)1.67117626
111Broad phalanx (HP:0006009)1.66879959
112Angiofibromas (HP:0010615)1.66710698
113Adenoma sebaceum (HP:0009720)1.66710698
114Limb-girdle muscle weakness (HP:0003325)1.65524792
115Absent eyebrow (HP:0002223)1.65497918
116EEG with generalized epileptiform discharges (HP:0011198)1.65245789
117Hallux valgus (HP:0001822)1.65003607
118Hypsarrhythmia (HP:0002521)1.64730688
119Broad palm (HP:0001169)1.64674716
120Asymmetry of the thorax (HP:0001555)1.64521334
121Trigonocephaly (HP:0000243)1.64418900
122Narrow nasal bridge (HP:0000446)1.64248807
123Nuclear cataract (HP:0100018)1.63933139
124Generalized hypotonia (HP:0001290)1.63603925
125Hip contracture (HP:0003273)1.63328524
126Rocker bottom foot (HP:0001838)1.63188094
127Apathy (HP:0000741)1.62986962
128Lymphangioma (HP:0100764)1.62743920
129Overgrowth (HP:0001548)1.62696091
130Wrist flexion contracture (HP:0001239)1.62344407
131Cutaneous syndactyly (HP:0012725)1.62162274
132Obstructive sleep apnea (HP:0002870)1.62155537
133Abnormality of the lower motor neuron (HP:0002366)1.61873343
134Hypoplastic female external genitalia (HP:0012815)1.61850087
135Aplasia involving bones of the upper limbs (HP:0009823)1.61534829
136Aplasia of the phalanges of the hand (HP:0009802)1.61534829
137Aplasia involving bones of the extremities (HP:0009825)1.61534829
138Thin ribs (HP:0000883)1.61415517
139Epileptiform EEG discharges (HP:0011182)1.60987530
140Impaired vibration sensation in the lower limbs (HP:0002166)1.60853158
141Follicular hyperkeratosis (HP:0007502)1.60766910
142Fibroma (HP:0010614)1.59046233
143Annular pancreas (HP:0001734)1.58758505
144Dilatation of the ascending aorta (HP:0005111)1.58424684
145Decreased muscle mass (HP:0003199)1.58396413
146Exostoses (HP:0100777)1.57886982
147Wide anterior fontanel (HP:0000260)1.57384709
148Drooling (HP:0002307)1.57052512
149Excessive salivation (HP:0003781)1.57052512
150Abnormality of the middle phalanges of the toes (HP:0010183)1.56857847
151Bronchomalacia (HP:0002780)1.56658104
152Arnold-Chiari malformation (HP:0002308)1.56575228
153Duplication of thumb phalanx (HP:0009942)1.55977479
154Broad finger (HP:0001500)1.55674296
155Adducted thumb (HP:0001181)1.55315785
156Narrow palate (HP:0000189)1.54659372
157Sporadic (HP:0003745)1.54487453
158Enlarged penis (HP:0000040)1.54001432
159Hypercortisolism (HP:0001578)1.53500996
160Intestinal atresia (HP:0011100)1.53490301
161Abnormality of the radial head (HP:0003995)1.53371900
162Pelvic girdle muscle weakness (HP:0003749)1.52827318
163Vaginal atresia (HP:0000148)1.52320848
164Megalencephaly (HP:0001355)1.52068844
165Tracheal stenosis (HP:0002777)1.51893245
166Absent eyelashes (HP:0000561)1.51512216
167Dental crowding (HP:0000678)1.51162077
168Increased nuchal translucency (HP:0010880)1.50742048
169Supernumerary spleens (HP:0009799)1.50500952
170Broad phalanges of the hand (HP:0009768)1.50287690
171Mild short stature (HP:0003502)1.50082298
172Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.47649510
173Genital tract atresia (HP:0001827)1.46891470
174Optic nerve hypoplasia (HP:0000609)1.46838845
175Patent foramen ovale (HP:0001655)1.45636222
176Abnormality of the ischium (HP:0003174)1.45153597
177Renal hypoplasia (HP:0000089)1.45047988
178Abnormality of the calcaneus (HP:0008364)1.44470061
179Aplasia/Hypoplasia of the breasts (HP:0010311)1.42392832
180Synostosis involving the elbow (HP:0003938)1.40144608
181Humeroradial synostosis (HP:0003041)1.40144608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.19776011
2NTRK33.02659914
3NTRK12.93276791
4MAP3K102.86243618
5MINK12.77625345
6MAP3K92.64772253
7LATS22.61850833
8TNIK2.59744873
9PDGFRA2.46865136
10PLK22.29469643
11CASK2.28342970
12MAP3K42.21771800
13TRIB32.15976846
14MKNK22.04939458
15PAK61.95278433
16KSR11.89204778
17LATS11.85785378
18TIE11.82618640
19TAF11.82469782
20UHMK11.79118416
21PRKD31.77608040
22TTK1.74500969
23NTRK21.72128710
24TSSK61.70193418
25SCYL21.56918154
26RIPK11.51633233
27KSR21.51374758
28BUB11.50410350
29PAK31.49644947
30STK38L1.47002936
31MYLK1.43009801
32EPHB21.42622780
33BCR1.41028814
34VRK21.40872765
35PLK41.39776017
36MAPK131.35097625
37PTK61.34852954
38DDR21.34491336
39EEF2K1.31916205
40EPHA41.30691269
41NUAK11.27404958
42PKN21.24858288
43CDK141.22461876
44BRSK11.20827240
45LIMK11.20600585
46LRRK21.19562750
47TYRO31.17379873
48BRSK21.17257730
49CSNK1G11.16875324
50MAP2K71.14607784
51STK31.12658578
52MAP2K41.12495656
53DAPK21.11709609
54STK101.10468710
55ERBB31.10428873
56FLT31.08612465
57RET1.08317303
58CDC71.06001303
59STK241.04583052
60SRPK11.04442667
61CAMKK11.04322311
62TGFBR11.03268855
63CDK51.02785288
64CDK181.01660117
65DAPK11.00902261
66PTK21.00510165
67WNK31.00143494
68RPS6KA20.98774288
69CDK150.98657243
70TRIM280.96511631
71FER0.93342212
72BCKDK0.93298037
73MAP3K120.92598371
74ERBB40.91966637
75ALK0.91603265
76MUSK0.91501246
77EIF2AK30.90850350
78ROCK20.88338415
79FGFR10.86758412
80FGFR20.86236303
81CDK11A0.85865938
82PINK10.85852906
83MAP3K20.85757628
84VRK10.85742966
85PLK10.85638286
86PRKCE0.82383143
87PNCK0.82235455
88MAP3K50.80929566
89PLK30.79654864
90CSNK1G20.78112976
91ADRBK10.78086047
92HIPK20.77810500
93NEK10.77582907
94DYRK1A0.73729333
95ROCK10.73138110
96PASK0.70689952
97MET0.70608608
98ZAK0.69119461
99PBK0.68147195
100DMPK0.67368247
101NLK0.65576811
102NEK20.65099861
103PDGFRB0.64767950
104MAP3K80.64717727
105PAK20.60399999
106DAPK30.60271127
107PTK2B0.60126703
108SIK20.59519163
109DYRK20.54931027
110BMPR1B0.54777129
111MKNK10.54413155
112CAMK2A0.53268133
113BRAF0.52620878
114ILK0.51293326
115ARAF0.50974014
116PRKCG0.50536235
117MAP2K10.50148355
118MOS0.49134735
119MTOR0.48732703
120MAPK100.48724684
121CDC42BPA0.48567258
122CAMK2D0.48447440
123TTN0.48447388
124WNK10.48387917
125TESK10.48350639
126PRKG20.48320388
127DYRK30.48033599
128PRKCH0.46379583
129PHKG10.46352711
130PHKG20.46352711
131CDK190.45761039
132CAMK1G0.44698671
133CSNK1G30.44612572
134ICK0.43555474
135PAK40.42690241
136CSNK1A1L0.42536353
137ERBB20.42071909
138RAF10.41955106
139CHEK20.41530801
140WEE10.41507885
141CAMK2B0.40998640
142ACVR1B0.40500753
143MARK20.40203440
144CSNK1E0.39962481
145PRKDC0.39818705
146MAPK90.39541420

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.15621565
2Synaptic vesicle cycle_Homo sapiens_hsa047212.06017717
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.03763564
4Circadian entrainment_Homo sapiens_hsa047132.02081177
5Long-term potentiation_Homo sapiens_hsa047201.98101611
6Dopaminergic synapse_Homo sapiens_hsa047281.97039736
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96470408
8Protein export_Homo sapiens_hsa030601.94897462
9Amphetamine addiction_Homo sapiens_hsa050311.94589427
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84218623
11Insulin secretion_Homo sapiens_hsa049111.84001051
12Nicotine addiction_Homo sapiens_hsa050331.83054770
13Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.78436622
14Cocaine addiction_Homo sapiens_hsa050301.72085099
15Gap junction_Homo sapiens_hsa045401.70679130
16GABAergic synapse_Homo sapiens_hsa047271.69313529
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68816182
18Cholinergic synapse_Homo sapiens_hsa047251.68283705
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61756124
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60222700
21Steroid biosynthesis_Homo sapiens_hsa001001.59860931
22Glutamatergic synapse_Homo sapiens_hsa047241.58114389
23Estrogen signaling pathway_Homo sapiens_hsa049151.54764257
24Axon guidance_Homo sapiens_hsa043601.54344739
25Glioma_Homo sapiens_hsa052141.53111017
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49817360
27Melanogenesis_Homo sapiens_hsa049161.49114941
28Oocyte meiosis_Homo sapiens_hsa041141.48482231
29Olfactory transduction_Homo sapiens_hsa047401.48011405
30Mismatch repair_Homo sapiens_hsa034301.44779892
31Morphine addiction_Homo sapiens_hsa050321.43626863
32Protein digestion and absorption_Homo sapiens_hsa049741.43301386
33Renin secretion_Homo sapiens_hsa049241.43264968
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.39880738
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36258038
36Hedgehog signaling pathway_Homo sapiens_hsa043401.33531691
37Hippo signaling pathway_Homo sapiens_hsa043901.31009629
38Oxytocin signaling pathway_Homo sapiens_hsa049211.29950431
39GnRH signaling pathway_Homo sapiens_hsa049121.27970765
40Long-term depression_Homo sapiens_hsa047301.27616460
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24531312
42Non-homologous end-joining_Homo sapiens_hsa034501.23123242
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.21220069
44Gastric acid secretion_Homo sapiens_hsa049711.20852961
45ErbB signaling pathway_Homo sapiens_hsa040121.17216739
46Salivary secretion_Homo sapiens_hsa049701.16820605
47Serotonergic synapse_Homo sapiens_hsa047261.14497209
48Vitamin B6 metabolism_Homo sapiens_hsa007501.14315102
49Basal cell carcinoma_Homo sapiens_hsa052171.13699142
50Basal transcription factors_Homo sapiens_hsa030221.13162103
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12574584
52Type II diabetes mellitus_Homo sapiens_hsa049301.11430123
53Colorectal cancer_Homo sapiens_hsa052101.11113663
54Wnt signaling pathway_Homo sapiens_hsa043101.09371682
55RNA transport_Homo sapiens_hsa030131.08283308
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08025098
57Dilated cardiomyopathy_Homo sapiens_hsa054141.07172622
58Vibrio cholerae infection_Homo sapiens_hsa051101.06569700
59mTOR signaling pathway_Homo sapiens_hsa041501.05361013
60mRNA surveillance pathway_Homo sapiens_hsa030151.04706083
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03270216
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03051813
63Endometrial cancer_Homo sapiens_hsa052131.02824969
64Selenocompound metabolism_Homo sapiens_hsa004501.02669104
65Spliceosome_Homo sapiens_hsa030401.01996007
66RNA degradation_Homo sapiens_hsa030181.01267837
67Taste transduction_Homo sapiens_hsa047420.99324288
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98439819
69Thyroid hormone synthesis_Homo sapiens_hsa049180.97963293
70Propanoate metabolism_Homo sapiens_hsa006400.97113371
71Proteoglycans in cancer_Homo sapiens_hsa052050.96790897
72Chronic myeloid leukemia_Homo sapiens_hsa052200.94587305
73Alcoholism_Homo sapiens_hsa050340.94246215
74Proteasome_Homo sapiens_hsa030500.94198660
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93988183
76Parkinsons disease_Homo sapiens_hsa050120.93736993
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92228491
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.90945690
79DNA replication_Homo sapiens_hsa030300.90683796
80VEGF signaling pathway_Homo sapiens_hsa043700.90142949
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89384400
82N-Glycan biosynthesis_Homo sapiens_hsa005100.89363772
83cAMP signaling pathway_Homo sapiens_hsa040240.88414652
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88071830
85Renal cell carcinoma_Homo sapiens_hsa052110.86485574
86Biosynthesis of amino acids_Homo sapiens_hsa012300.86196223
87Nucleotide excision repair_Homo sapiens_hsa034200.85805134
88Focal adhesion_Homo sapiens_hsa045100.85451437
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84787694
90Calcium signaling pathway_Homo sapiens_hsa040200.83945764
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83486148
92Glucagon signaling pathway_Homo sapiens_hsa049220.83389239
93Huntingtons disease_Homo sapiens_hsa050160.82689896
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82575134
95Fanconi anemia pathway_Homo sapiens_hsa034600.82100386
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82023587
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81682033
98Rap1 signaling pathway_Homo sapiens_hsa040150.81169848
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81169619
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79873526
101MAPK signaling pathway_Homo sapiens_hsa040100.79624602
102Dorso-ventral axis formation_Homo sapiens_hsa043200.78666296
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.77948308
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.77496771
105Pyruvate metabolism_Homo sapiens_hsa006200.77259223
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76625145
107Non-small cell lung cancer_Homo sapiens_hsa052230.76540418
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76334406
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76075292
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74595331
111Ribosome_Homo sapiens_hsa030100.74110441
112Oxidative phosphorylation_Homo sapiens_hsa001900.73934823
113Thyroid cancer_Homo sapiens_hsa052160.73496075
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72378045
115Base excision repair_Homo sapiens_hsa034100.72164446
116RNA polymerase_Homo sapiens_hsa030200.72060734
117Pathways in cancer_Homo sapiens_hsa052000.71999897
118Insulin signaling pathway_Homo sapiens_hsa049100.70541531
119p53 signaling pathway_Homo sapiens_hsa041150.69714321
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69679037
121MicroRNAs in cancer_Homo sapiens_hsa052060.69653290
122Fatty acid elongation_Homo sapiens_hsa000620.69081831
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68874922
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.68258004
125Alzheimers disease_Homo sapiens_hsa050100.67380935
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65973146
127Adherens junction_Homo sapiens_hsa045200.64847568
128Endocytosis_Homo sapiens_hsa041440.64085432
129Melanoma_Homo sapiens_hsa052180.63788957
130TGF-beta signaling pathway_Homo sapiens_hsa043500.63259692
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61884116
132Cell cycle_Homo sapiens_hsa041100.61297810
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61181025
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60684104
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60243913
136Bladder cancer_Homo sapiens_hsa052190.59013901
137Ras signaling pathway_Homo sapiens_hsa040140.58748845
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58058595
139Tight junction_Homo sapiens_hsa045300.58016762
140Homologous recombination_Homo sapiens_hsa034400.57467799
141Circadian rhythm_Homo sapiens_hsa047100.57128483
142Cardiac muscle contraction_Homo sapiens_hsa042600.56935463
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55556624
144Folate biosynthesis_Homo sapiens_hsa007900.55008819
145Notch signaling pathway_Homo sapiens_hsa043300.55004443
146Choline metabolism in cancer_Homo sapiens_hsa052310.54739525
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52874960

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