ARMC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)5.68098485
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.22389867
3DNA strand renaturation (GO:0000733)4.80940152
4replication fork processing (GO:0031297)4.75459350
5transcription from mitochondrial promoter (GO:0006390)4.45856072
6epithelial cilium movement (GO:0003351)4.42440052
7regulation of cilium movement (GO:0003352)4.26474007
8positive regulation of protein homooligomerization (GO:0032464)4.05432168
9regulation of protein homooligomerization (GO:0032462)4.03522182
10negative regulation of axon guidance (GO:1902668)4.02366959
11proline metabolic process (GO:0006560)3.98341050
12regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.95740602
13negative regulation of axon extension involved in axon guidance (GO:0048843)3.95653058
14oxidative demethylation (GO:0070989)3.90143330
15embryonic process involved in female pregnancy (GO:0060136)3.88832013
16behavioral response to nicotine (GO:0035095)3.86001944
17synaptic vesicle endocytosis (GO:0048488)3.80416192
18axonemal dynein complex assembly (GO:0070286)3.79111258
19endocardial cushion development (GO:0003197)3.78444599
20maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.78107140
21poly(A)+ mRNA export from nucleus (GO:0016973)3.77790354
22cilium or flagellum-dependent cell motility (GO:0001539)3.74885396
23negative regulation of protein oligomerization (GO:0032460)3.74803126
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.73322795
25cellular response to ATP (GO:0071318)3.73068320
26cell migration involved in heart development (GO:0060973)3.69972431
27response to pheromone (GO:0019236)3.68262083
28cilium movement (GO:0003341)3.66139289
29auditory receptor cell stereocilium organization (GO:0060088)3.65359196
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.62098535
31positive regulation of gastrulation (GO:2000543)3.59628354
32regulation of respiratory system process (GO:0044065)3.51990702
33establishment of apical/basal cell polarity (GO:0035089)3.45997942
34positive regulation of dendritic spine morphogenesis (GO:0061003)3.43906919
35histone H4-K12 acetylation (GO:0043983)3.41209816
36establishment or maintenance of monopolar cell polarity (GO:0061339)3.39683975
37establishment of monopolar cell polarity (GO:0061162)3.39683975
38synaptic vesicle exocytosis (GO:0016079)3.38264827
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.37971695
40inner ear receptor stereocilium organization (GO:0060122)3.36194294
41cell migration in hindbrain (GO:0021535)3.33847825
42synaptic vesicle docking involved in exocytosis (GO:0016081)3.31968966
43neuron projection extension involved in neuron projection guidance (GO:1902284)3.31197314
44axon extension involved in axon guidance (GO:0048846)3.31197314
45neuron cell-cell adhesion (GO:0007158)3.28839868
46regulation of hippo signaling (GO:0035330)3.27984885
47ionotropic glutamate receptor signaling pathway (GO:0035235)3.26017110
48convergent extension (GO:0060026)3.25532220
49cornea development in camera-type eye (GO:0061303)3.22601401
50protein polyglutamylation (GO:0018095)3.21297787
51embryonic forelimb morphogenesis (GO:0035115)3.20900672
52positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.20756969
53DNA integration (GO:0015074)3.19652326
54synaptic transmission, glutamatergic (GO:0035249)3.19494067
55regulation of glutamate receptor signaling pathway (GO:1900449)3.15586605
56regulation of cAMP-dependent protein kinase activity (GO:2000479)3.13495281
57anterior/posterior axis specification, embryo (GO:0008595)3.12507343
58intraciliary transport (GO:0042073)3.11833413
59pericardium development (GO:0060039)3.09011125
60DNA double-strand break processing (GO:0000729)3.08375627
61protein localization to synapse (GO:0035418)3.06919753
62negative regulation of Ras GTPase activity (GO:0034261)3.03227340
63locomotory exploration behavior (GO:0035641)3.02469539
64ganglion development (GO:0061548)3.02164260
65motile cilium assembly (GO:0044458)3.00924844
66regulation of integrin activation (GO:0033623)2.98580212
67regulation of respiratory gaseous exchange (GO:0043576)2.97719721
68vocalization behavior (GO:0071625)2.96065058
69inner ear receptor cell development (GO:0060119)2.94156448
70cilium morphogenesis (GO:0060271)2.93138825
71platelet dense granule organization (GO:0060155)2.92032832
72forelimb morphogenesis (GO:0035136)2.91002107
73glutamate receptor signaling pathway (GO:0007215)2.90985271
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90347784
75negative regulation of heart rate (GO:0010459)2.89138374
76neuromuscular process controlling posture (GO:0050884)2.88992832
77mitochondrion transport along microtubule (GO:0047497)2.87944256
78establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.87944256
79postsynaptic membrane organization (GO:0001941)2.87642428
80left/right pattern formation (GO:0060972)2.86850647
81regulation of axon guidance (GO:1902667)2.85842078
82metanephric mesenchyme development (GO:0072075)2.84496825
83mRNA polyadenylation (GO:0006378)2.82680434
84regulation of microtubule-based movement (GO:0060632)2.80725028
85positive regulation of synapse maturation (GO:0090129)2.80515650
86neuron-neuron synaptic transmission (GO:0007270)2.80293666
87DNA deamination (GO:0045006)2.79533687
88negative regulation of JAK-STAT cascade (GO:0046426)2.79511830
89axoneme assembly (GO:0035082)2.76745715
90retinal cone cell development (GO:0046549)2.76010165
91regulation of organ formation (GO:0003156)2.75600350
92secondary metabolite biosynthetic process (GO:0044550)2.74091079
93neuromuscular process controlling balance (GO:0050885)2.72485161
94regulation of gene silencing by RNA (GO:0060966)2.70798778
95regulation of posttranscriptional gene silencing (GO:0060147)2.70798778
96regulation of gene silencing by miRNA (GO:0060964)2.70798778
97ventricular septum development (GO:0003281)2.70082198
98somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70060964
99somatic hypermutation of immunoglobulin genes (GO:0016446)2.70060964
100nonmotile primary cilium assembly (GO:0035058)2.69751889
101mesenchymal-epithelial cell signaling (GO:0060638)2.68955153
102regulation of synaptic vesicle exocytosis (GO:2000300)2.68693694
103bone trabecula formation (GO:0060346)2.68215958
104spliceosomal tri-snRNP complex assembly (GO:0000244)2.67688271
105chondrocyte proliferation (GO:0035988)2.67684343
106regulation of neuronal synaptic plasticity (GO:0048168)2.67125288
107regulation of axon extension involved in axon guidance (GO:0048841)2.66277086
108neuromuscular process (GO:0050905)2.66201141
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65610848
110regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64271669
111regulation of mesoderm development (GO:2000380)2.64233127
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.63463446
113cilium organization (GO:0044782)2.63375619
114positive regulation of developmental pigmentation (GO:0048087)2.63140670
115collagen fibril organization (GO:0030199)2.62764010
116negative chemotaxis (GO:0050919)2.62258375
117kidney mesenchyme development (GO:0072074)2.61270413
118presynaptic membrane assembly (GO:0097105)2.60845685
119negative regulation of cell cycle arrest (GO:0071157)2.60470828
120cilium assembly (GO:0042384)2.60095898
121synaptic vesicle maturation (GO:0016188)2.60015307
122regulation of DNA damage checkpoint (GO:2000001)2.59527252
123determination of left/right symmetry (GO:0007368)2.56943189
124negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56508652
125positive regulation of male gonad development (GO:2000020)2.55574880
126dermatan sulfate biosynthetic process (GO:0030208)2.54616288
127mitochondrial DNA metabolic process (GO:0032042)2.54103572
128establishment of mitochondrion localization (GO:0051654)2.53552871
129mRNA cleavage (GO:0006379)2.53545248
130RNA polyadenylation (GO:0043631)2.52467642
131regulation of postsynaptic membrane potential (GO:0060078)2.52386099
132regulation of protein oligomerization (GO:0032459)2.52255760
133exploration behavior (GO:0035640)2.49877100
134protein localization to cilium (GO:0061512)2.49555308
135regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.49545573
136piRNA metabolic process (GO:0034587)2.49436579
137establishment of tissue polarity (GO:0007164)2.48807635
138establishment of planar polarity (GO:0001736)2.48807635
139base-excision repair, AP site formation (GO:0006285)2.48392655
140glutamate secretion (GO:0014047)2.48071843
141activation of Rac GTPase activity (GO:0032863)2.47994423
142pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.47646928
143outer ear morphogenesis (GO:0042473)2.47236048
144regulation of non-canonical Wnt signaling pathway (GO:2000050)2.47195403
145positive regulation of synaptic transmission, GABAergic (GO:0032230)2.46960545
146left/right axis specification (GO:0070986)2.46346992
147head development (GO:0060322)2.46284447
148smoothened signaling pathway (GO:0007224)2.46171473
149single strand break repair (GO:0000012)2.46010511
150protein heterotrimerization (GO:0070208)2.45467072
151neural crest cell development (GO:0014032)2.45420665
152endosome to pigment granule transport (GO:0043485)2.45214945
153endosome to melanosome transport (GO:0035646)2.45214945
154embryonic camera-type eye development (GO:0031076)2.45035116
155opioid receptor signaling pathway (GO:0038003)2.44780807
156response to redox state (GO:0051775)2.44484034
157lymphangiogenesis (GO:0001946)2.42482962
158regulation of male gonad development (GO:2000018)2.42404348
159determination of bilateral symmetry (GO:0009855)2.41993025
160artery development (GO:0060840)2.40608423
161negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.39183005
162kidney morphogenesis (GO:0060993)2.37748489
163specification of symmetry (GO:0009799)2.36959320
164retinal ganglion cell axon guidance (GO:0031290)2.36224146
165heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.31988874
166sympathetic nervous system development (GO:0048485)2.31401247
167virion attachment to host cell (GO:0019062)2.30779574
168adhesion of symbiont to host cell (GO:0044650)2.30779574
169melanin biosynthetic process (GO:0042438)2.30236850
170cell proliferation in forebrain (GO:0021846)2.29356730
171centriole replication (GO:0007099)2.29184647
172smooth muscle tissue development (GO:0048745)2.28219664
173female genitalia development (GO:0030540)2.28076732
174somite development (GO:0061053)2.25540526
175photoreceptor cell development (GO:0042461)2.22330065
176kynurenine metabolic process (GO:0070189)2.21824345
177dermatan sulfate metabolic process (GO:0030205)2.20603024
178negative regulation of mast cell activation (GO:0033004)2.20383861
179positive regulation of synapse assembly (GO:0051965)2.19330640
180embryonic digit morphogenesis (GO:0042733)2.19050857
181regulation of cardioblast proliferation (GO:0003264)2.18789989
182regulation of secondary heart field cardioblast proliferation (GO:0003266)2.18789989
183nodal signaling pathway (GO:0038092)2.18299089
184limb bud formation (GO:0060174)2.18249631
185negative regulation of embryonic development (GO:0045992)2.18245829
186appendage development (GO:0048736)2.17210114
187limb development (GO:0060173)2.17210114
188dorsal/ventral axis specification (GO:0009950)2.16773808
189negative regulation of telomere maintenance (GO:0032205)2.16103267
190lateral sprouting from an epithelium (GO:0060601)2.15796450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.38441753
2* ZNF274_21170338_ChIP-Seq_K562_Hela3.34196417
3GBX2_23144817_ChIP-Seq_PC3_Human2.90765657
4REST_21632747_ChIP-Seq_MESCs_Mouse2.58888796
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.54897799
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.51704355
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49397013
8* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.32375775
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.29002943
10RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.16264798
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.12621490
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.07976597
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.07843200
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06406973
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94292011
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94292011
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94292011
18* P300_19829295_ChIP-Seq_ESCs_Human1.92786247
19* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.88099748
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87982714
21EWS_26573619_Chip-Seq_HEK293_Human1.83436046
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.81872795
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81033006
24FUS_26573619_Chip-Seq_HEK293_Human1.78375070
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.77338962
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.74471961
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72594526
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71158282
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.69961767
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69910803
31RNF2_27304074_Chip-Seq_NSC_Mouse1.69472777
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69060348
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67935813
34* FLI1_27457419_Chip-Seq_LIVER_Mouse1.67685357
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66012563
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65185117
37NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.64785050
38POU5F1_16518401_ChIP-PET_MESCs_Mouse1.64086280
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63432119
40* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62592408
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61986344
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.55504585
43TP53_18474530_ChIP-ChIP_U2OS_Human1.53066589
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.52979743
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51734911
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51691192
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.51216350
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51058465
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49384769
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49286024
51* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47766888
52* CJUN_26792858_Chip-Seq_BT549_Human1.46930351
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46732925
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45827005
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43846895
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.43735543
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.43510542
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43469039
59DROSHA_22980978_ChIP-Seq_HELA_Human1.43303155
60VDR_22108803_ChIP-Seq_LS180_Human1.42803197
61BRD4_25478319_ChIP-Seq_HGPS_Human1.40850491
62TAF15_26573619_Chip-Seq_HEK293_Human1.39047526
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38322422
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37327791
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35761809
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35085447
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34609231
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.34193282
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34167533
70AR_25329375_ChIP-Seq_VCAP_Human1.33811390
71* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33193471
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32898398
73IRF1_19129219_ChIP-ChIP_H3396_Human1.32755426
74IGF1R_20145208_ChIP-Seq_DFB_Human1.32249981
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31388261
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28927439
77TP53_16413492_ChIP-PET_HCT116_Human1.27476793
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26357053
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25436757
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25140994
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24445289
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22152005
83SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.20807497
84EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20755916
85RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20755916
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19652787
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17958387
88TET1_21490601_ChIP-Seq_MESCs_Mouse1.17799958
89MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17576937
90TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17487438
91CBP_20019798_ChIP-Seq_JUKART_Human1.17230030
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17230030
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.16583303
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16451616
95JUN_21703547_ChIP-Seq_K562_Human1.16337790
96SMAD4_21741376_ChIP-Seq_EPCs_Human1.15085812
97EED_16625203_ChIP-ChIP_MESCs_Mouse1.14893142
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14591902
99BCAT_22108803_ChIP-Seq_LS180_Human1.13772369
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13730241
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13730241
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.13519597
103SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13137978
104TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10811637
105ER_23166858_ChIP-Seq_MCF-7_Human1.10773382
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10758929
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10311855
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09797939
109RUNX2_22187159_ChIP-Seq_PCA_Human1.09702547
110SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09554598
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.07037741
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07016911
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06937421
114TP63_19390658_ChIP-ChIP_HaCaT_Human1.06924675
115NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06603021
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06195481
117LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06052755
118GABP_17652178_ChIP-ChIP_JURKAT_Human1.05710253
119AHR_22903824_ChIP-Seq_MCF-7_Human1.05224142
120* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05112463
121MYC_18940864_ChIP-ChIP_HL60_Human1.04813418
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03921612
123EP300_21415370_ChIP-Seq_HL-1_Mouse1.03077464
124RING1B_27294783_Chip-Seq_ESCs_Mouse1.02591179
125HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01990701
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01899047
127* WDR5_24793694_ChIP-Seq_LNCAP_Human1.00477958
128STAT3_18555785_ChIP-Seq_MESCs_Mouse0.99964993
129TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99657552
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99116033
131THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98863521
132TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98803213
133E2F1_17053090_ChIP-ChIP_MCF-7_Human0.98572581
134PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98444846
135STAT3_23295773_ChIP-Seq_U87_Human0.98292090
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97307252
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97076161
138AR_21572438_ChIP-Seq_LNCaP_Human0.96120212
139SOX9_26525672_Chip-Seq_HEART_Mouse0.94969672
140POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94537830
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93861524
142ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92523929
143* TCF4_23295773_ChIP-Seq_U87_Human0.92410344
144YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92092539
145SMAD4_21799915_ChIP-Seq_A2780_Human0.91925450
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91712839
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91712839
148NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.91593167
149* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91121445
150* TP53_20018659_ChIP-ChIP_R1E_Mouse0.90409973
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90193425
152CTCF_27219007_Chip-Seq_Bcells_Human0.90100955
153SPI1_26923725_Chip-Seq_HPCs_Mouse0.89984850
154NANOG_21062744_ChIP-ChIP_HESCs_Human0.89468655
155KDM2B_26808549_Chip-Seq_K562_Human0.89156793
156TET1_21451524_ChIP-Seq_MESCs_Mouse0.88578162
157* AR_19668381_ChIP-Seq_PC3_Human0.87511349
158TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.87411601
159NANOG_16518401_ChIP-PET_MESCs_Mouse0.87396144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.03327030
2MP0004859_abnormal_synaptic_plasticity3.95581658
3MP0005503_abnormal_tendon_morphology3.74843525
4MP0005257_abnormal_intraocular_pressure3.42197163
5MP0005171_absent_coat_pigmentation3.03895511
6MP0008438_abnormal_cutaneous_collagen2.99961450
7MP0003880_abnormal_central_pattern2.87660657
8MP0008877_abnormal_DNA_methylation2.85349229
9MP0008057_abnormal_DNA_replication2.75664867
10MP0006072_abnormal_retinal_apoptosis2.68382897
11MP0002938_white_spotting2.58497065
12MP0003635_abnormal_synaptic_transmissio2.54662546
13MP0000372_irregular_coat_pigmentation2.54001367
14MP0002653_abnormal_ependyma_morphology2.52129942
15MP0004233_abnormal_muscle_weight2.45002279
16MP0009046_muscle_twitch2.35591898
17MP0002572_abnormal_emotion/affect_behav2.32766986
18MP0002063_abnormal_learning/memory/cond2.27826131
19MP0005645_abnormal_hypothalamus_physiol2.17358708
20MP0009384_cardiac_valve_regurgitation2.11370724
21MP0003283_abnormal_digestive_organ2.03503060
22MP0009745_abnormal_behavioral_response2.01669701
23MP0001968_abnormal_touch/_nociception2.00737795
24MP0002064_seizures2.00397113
25MP0010386_abnormal_urinary_bladder1.99167786
26MP0005410_abnormal_fertilization1.99009445
27MP0003890_abnormal_embryonic-extraembry1.89130260
28MP0004133_heterotaxia1.87198425
29MP0001542_abnormal_bone_strength1.84644690
30MP0003787_abnormal_imprinting1.78608103
31MP0004270_analgesia1.77353183
32MP0001299_abnormal_eye_distance/1.77134765
33MP0003937_abnormal_limbs/digits/tail_de1.70545491
34MP0010030_abnormal_orbit_morphology1.70110657
35MP0006292_abnormal_olfactory_placode1.69822066
36MP0002736_abnormal_nociception_after1.68801662
37MP0002254_reproductive_system_inflammat1.62863149
38MP0002272_abnormal_nervous_system1.62650221
39MP0006054_spinal_hemorrhage1.62091781
40MP0001188_hyperpigmentation1.62030652
41MP0005253_abnormal_eye_physiology1.61899163
42MP0008995_early_reproductive_senescence1.61569354
43MP0003279_aneurysm1.59260028
44MP0005508_abnormal_skeleton_morphology1.58607289
45MP0005646_abnormal_pituitary_gland1.57683586
46MP0009250_abnormal_appendicular_skeleto1.54367702
47MP0002733_abnormal_thermal_nociception1.53367176
48MP0004272_abnormal_basement_membrane1.52710886
49MP0000778_abnormal_nervous_system1.52187739
50MP0002735_abnormal_chemical_nociception1.51356571
51MP0001486_abnormal_startle_reflex1.51250665
52MP0005551_abnormal_eye_electrophysiolog1.47732589
53MP0000955_abnormal_spinal_cord1.47074747
54MP0003950_abnormal_plasma_membrane1.46183554
55MP0001970_abnormal_pain_threshold1.43578572
56MP0002067_abnormal_sensory_capabilities1.41114183
57MP0000015_abnormal_ear_pigmentation1.40800244
58MP0003119_abnormal_digestive_system1.40713596
59MP0003698_abnormal_male_reproductive1.40653193
60MP0002734_abnormal_mechanical_nocicepti1.40490449
61MP0000538_abnormal_urinary_bladder1.39691465
62MP0001293_anophthalmia1.36043100
63MP0005174_abnormal_tail_pigmentation1.34246060
64MP0003942_abnormal_urinary_system1.33192570
65MP0002184_abnormal_innervation1.32327782
66MP0001502_abnormal_circadian_rhythm1.31291337
67MP0005197_abnormal_uvea_morphology1.29641482
68MP0004142_abnormal_muscle_tone1.28270639
69MP0003122_maternal_imprinting1.27688667
70MP0008789_abnormal_olfactory_epithelium1.27651305
71MP0004811_abnormal_neuron_physiology1.27154878
72MP0002822_catalepsy1.25436761
73MP0002882_abnormal_neuron_morphology1.25214390
74MP0002837_dystrophic_cardiac_calcinosis1.23987968
75MP0002095_abnormal_skin_pigmentation1.22808475
76MP0009278_abnormal_bone_marrow1.22078480
77MP0002295_abnormal_pulmonary_circulatio1.21843840
78MP0005275_abnormal_skin_tensile1.21301904
79MP0003195_calcinosis1.21231885
80MP0001958_emphysema1.20940932
81MP0000371_diluted_coat_color1.20933695
82MP0002249_abnormal_larynx_morphology1.20447286
83MP0005423_abnormal_somatic_nervous1.19867923
84MP0002557_abnormal_social/conspecific_i1.17846015
85MP0001984_abnormal_olfaction1.17827980
86MP0008058_abnormal_DNA_repair1.16611152
87MP0001929_abnormal_gametogenesis1.15571560
88MP0003172_abnormal_lysosome_physiology1.15467793
89MP0005377_hearing/vestibular/ear_phenot1.14982922
90MP0003878_abnormal_ear_physiology1.14982922
91MP0003941_abnormal_skin_development1.14532772
92MP0000534_abnormal_ureter_morphology1.14120595
93MP0002160_abnormal_reproductive_system1.12487253
94MP0000631_abnormal_neuroendocrine_gland1.09940108
95MP0002233_abnormal_nose_morphology1.08223015
96MP0001440_abnormal_grooming_behavior1.07671177
97MP0002152_abnormal_brain_morphology1.04557615
98MP0001501_abnormal_sleep_pattern1.01973187
99MP0000569_abnormal_digit_pigmentation1.01971094
100MP0002638_abnormal_pupillary_reflex1.01674943
101MP0002066_abnormal_motor_capabilities/c1.01290169
102MP0002282_abnormal_trachea_morphology1.00411130
103MP0000427_abnormal_hair_cycle0.99492819
104MP0004924_abnormal_behavior0.98296530
105MP0005386_behavior/neurological_phenoty0.98296530
106MP0002752_abnormal_somatic_nervous0.97985788
107MP0002210_abnormal_sex_determination0.95630795
108MP0010094_abnormal_chromosome_stability0.95592556
109MP0004885_abnormal_endolymph0.95398912
110MP0005391_vision/eye_phenotype0.94478272
111MP0005408_hypopigmentation0.94253182
112MP0002109_abnormal_limb_morphology0.94223404
113MP0005394_taste/olfaction_phenotype0.93790918
114MP0005499_abnormal_olfactory_system0.93790918
115MP0004043_abnormal_pH_regulation0.93771220
116MP0000428_abnormal_craniofacial_morphol0.93646982
117MP0003861_abnormal_nervous_system0.92088604
118MP0002009_preneoplasia0.91562682
119MP0002116_abnormal_craniofacial_bone0.89526920
120MP0001145_abnormal_male_reproductive0.89145163
121MP0002161_abnormal_fertility/fecundity0.89000062
122MP0008569_lethality_at_weaning0.87362736
123MP0002108_abnormal_muscle_morphology0.85718732
124MP0002102_abnormal_ear_morphology0.85181965
125MP0000432_abnormal_head_morphology0.83603440
126MP0001286_abnormal_eye_development0.83427585
127MP0003786_premature_aging0.83365625
128MP0001529_abnormal_vocalization0.83313834
129MP0000678_abnormal_parathyroid_gland0.83241121
130MP0001324_abnormal_eye_pigmentation0.82276705
131MP0002115_abnormal_skeleton_extremities0.81629774
132MP0003121_genomic_imprinting0.81470474
133MP0002234_abnormal_pharynx_morphology0.81452230
134MP0005195_abnormal_posterior_eye0.80883629
135MP0002177_abnormal_outer_ear0.80664749
136MP0000049_abnormal_middle_ear0.80526084
137MP0002751_abnormal_autonomic_nervous0.80493448
138MP0004858_abnormal_nervous_system0.79767013
139MP0002090_abnormal_vision0.79592885
140MP0002114_abnormal_axial_skeleton0.79267238
141MP0001485_abnormal_pinna_reflex0.78230465
142MP0005623_abnormal_meninges_morphology0.77973713
143MP0002075_abnormal_coat/hair_pigmentati0.77030729
144MP0003755_abnormal_palate_morphology0.76646934
145MP0005595_abnormal_vascular_smooth0.76333848
146MP0002084_abnormal_developmental_patter0.75324686
147MP0001963_abnormal_hearing_physiology0.75271908
148MP0000026_abnormal_inner_ear0.74821503
149MP0000653_abnormal_sex_gland0.74584227
150MP0006276_abnormal_autonomic_nervous0.74554497
151MP0000462_abnormal_digestive_system0.73839305
152MP0003633_abnormal_nervous_system0.73619218
153MP0000163_abnormal_cartilage_morphology0.72633624
154MP0005389_reproductive_system_phenotype0.70410977
155MP0002697_abnormal_eye_size0.70170749
156MP0005187_abnormal_penis_morphology0.70059542
157MP0003935_abnormal_craniofacial_develop0.69607416
158MP0009053_abnormal_anal_canal0.69440382
159MP0005075_abnormal_melanosome_morpholog0.69229452
160MP0002909_abnormal_adrenal_gland0.69143587

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)4.30787639
2Abnormal respiratory epithelium morphology (HP:0012253)4.29007318
3Abnormal respiratory motile cilium morphology (HP:0005938)4.29007318
4Focal motor seizures (HP:0011153)4.21804754
5Absent/shortened dynein arms (HP:0200106)3.87404481
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.87404481
7Pancreatic fibrosis (HP:0100732)3.79328022
8True hermaphroditism (HP:0010459)3.70199908
9Epileptic encephalopathy (HP:0200134)3.63915686
10Pancreatic cysts (HP:0001737)3.51468982
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.50371353
12Rib fusion (HP:0000902)3.29249174
13Atonic seizures (HP:0010819)3.25661554
14Abnormality of the lower motor neuron (HP:0002366)3.08344080
15Annular pancreas (HP:0001734)3.07960371
16Gait imbalance (HP:0002141)3.02388445
17Aplasia/Hypoplasia of the fovea (HP:0008060)2.95797135
18Hypoplasia of the fovea (HP:0007750)2.95797135
19Premature rupture of membranes (HP:0001788)2.95240517
20Abnormality of the renal medulla (HP:0100957)2.93380151
21Concave nail (HP:0001598)2.91745163
22Myokymia (HP:0002411)2.89815184
23Medial flaring of the eyebrow (HP:0010747)2.88934538
24Congenital primary aphakia (HP:0007707)2.86429895
25Facial hemangioma (HP:0000329)2.80360982
26Abnormal respiratory motile cilium physiology (HP:0012261)2.73457021
27Abnormal ciliary motility (HP:0012262)2.73431010
28Rectal fistula (HP:0100590)2.73127556
29Rectovaginal fistula (HP:0000143)2.73127556
30Intestinal fistula (HP:0100819)2.72547321
31Tubular atrophy (HP:0000092)2.70814425
32Intestinal atresia (HP:0011100)2.70622104
33Keratoconus (HP:0000563)2.66910287
34Increased corneal curvature (HP:0100692)2.66910287
35Aplasia/Hypoplasia of the tongue (HP:0010295)2.63854656
36Nephrogenic diabetes insipidus (HP:0009806)2.62577063
37Median cleft lip (HP:0000161)2.61318162
38Chronic hepatic failure (HP:0100626)2.60924490
39Abnormality of the fovea (HP:0000493)2.58083668
40Tongue fasciculations (HP:0001308)2.58012663
41Cystic liver disease (HP:0006706)2.56813411
42Focal seizures (HP:0007359)2.52710041
43Narrow nasal bridge (HP:0000446)2.51738692
44Type II lissencephaly (HP:0007260)2.51445659
45Aplasia of the musculature (HP:0100854)2.50049748
46Hypochromic microcytic anemia (HP:0004840)2.48266222
47Progressive cerebellar ataxia (HP:0002073)2.44604358
48Occipital encephalocele (HP:0002085)2.44592115
49Protrusio acetabuli (HP:0003179)2.43038340
50Turricephaly (HP:0000262)2.40510539
51Abnormality of dentin (HP:0010299)2.39380605
52Soft skin (HP:0000977)2.36366625
53Vaginal atresia (HP:0000148)2.34772755
54Genital tract atresia (HP:0001827)2.32649172
55Abnormality of the labia minora (HP:0012880)2.28566737
56Coronal craniosynostosis (HP:0004440)2.27698334
57Anteriorly placed anus (HP:0001545)2.26570152
58Absence seizures (HP:0002121)2.25264305
59Ankle contracture (HP:0006466)2.25211397
60Poor coordination (HP:0002370)2.24250481
61Rhinitis (HP:0012384)2.24174263
62Nephronophthisis (HP:0000090)2.23994105
63Abnormality of the aortic arch (HP:0012303)2.23753191
64Clumsiness (HP:0002312)2.23434550
65Hypotelorism (HP:0000601)2.22575606
66Broad metatarsal (HP:0001783)2.21416597
67Poikiloderma (HP:0001029)2.20050584
68Anencephaly (HP:0002323)2.20049351
69Vaginal fistula (HP:0004320)2.19636481
70Male infertility (HP:0003251)2.19015139
71Alacrima (HP:0000522)2.17989157
72Orthostatic hypotension (HP:0001278)2.17588631
73Neonatal short-limb short stature (HP:0008921)2.17466793
74Visual hallucinations (HP:0002367)2.15647011
75Muscle fibrillation (HP:0010546)2.15449321
76Infertility (HP:0000789)2.13979289
77Congenital hepatic fibrosis (HP:0002612)2.13331571
78Acute lymphatic leukemia (HP:0006721)2.12454920
79Dysdiadochokinesis (HP:0002075)2.11367491
80Dysautonomia (HP:0002459)2.10831677
81Short humerus (HP:0005792)2.10442332
82Septo-optic dysplasia (HP:0100842)2.09933769
83Bifid tongue (HP:0010297)2.09673105
84Ectopic anus (HP:0004397)2.09427316
85Sclerocornea (HP:0000647)2.09339783
86Postaxial hand polydactyly (HP:0001162)2.09013828
87Follicular hyperkeratosis (HP:0007502)2.06604047
88Morphological abnormality of the middle ear (HP:0008609)2.04781949
89White forelock (HP:0002211)2.04693160
90Volvulus (HP:0002580)2.04678893
91Broad alveolar ridges (HP:0000187)2.03487005
92Absent radius (HP:0003974)2.03076376
93Nephroblastoma (Wilms tumor) (HP:0002667)2.03051572
94Congenital sensorineural hearing impairment (HP:0008527)2.02466347
95Increased IgM level (HP:0003496)2.00989518
96Tubulointerstitial fibrosis (HP:0005576)1.99343060
97Gaze-evoked nystagmus (HP:0000640)1.98704776
98Hypoventilation (HP:0002791)1.96061034
99Optic nerve hypoplasia (HP:0000609)1.95451114
100Dialeptic seizures (HP:0011146)1.95386940
101Partial duplication of the phalanx of hand (HP:0009999)1.95378413
102Postaxial foot polydactyly (HP:0001830)1.95188611
103Aplasia/hypoplasia of the humerus (HP:0006507)1.94942510
104Congenital stationary night blindness (HP:0007642)1.94241526
105Aplasia involving forearm bones (HP:0009822)1.93603793
106Absent forearm bone (HP:0003953)1.93603793
107Tented upper lip vermilion (HP:0010804)1.93285902
108Aplasia/Hypoplasia involving the musculature (HP:0001460)1.93085087
109Decreased lacrimation (HP:0000633)1.92511142
110Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92369537
111Anophthalmia (HP:0000528)1.91262350
112Abnormality of the renal cortex (HP:0011035)1.90815113
113Aortic aneurysm (HP:0004942)1.88731109
114Embryonal renal neoplasm (HP:0011794)1.88445376
115Mesomelia (HP:0003027)1.87220094
116Increased number of teeth (HP:0011069)1.85657802
117Supernumerary spleens (HP:0009799)1.85477949
118Bladder diverticulum (HP:0000015)1.85334927
119Genetic anticipation (HP:0003743)1.85052712
120Patchy hypopigmentation of hair (HP:0011365)1.84412084
121Abnormal biliary tract physiology (HP:0012439)1.83938866
122Bile duct proliferation (HP:0001408)1.83938866
123Bowel diverticulosis (HP:0005222)1.83493360
124Congenital hip dislocation (HP:0001374)1.82475640
125Large for gestational age (HP:0001520)1.82233840
126Pendular nystagmus (HP:0012043)1.81821191
127Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80884498
128Impaired smooth pursuit (HP:0007772)1.80558805
129Wide anterior fontanel (HP:0000260)1.80131429
130Tubulointerstitial abnormality (HP:0001969)1.80047261
131Hamartoma (HP:0010566)1.78630667
132Short chin (HP:0000331)1.78505999
133Pancreatic islet-cell hyperplasia (HP:0004510)1.77996088
134Lissencephaly (HP:0001339)1.77824787
135Long toe (HP:0010511)1.77125035
136Specific learning disability (HP:0001328)1.75257756
137Preaxial hand polydactyly (HP:0001177)1.75184343
138Aortic dissection (HP:0002647)1.74519640
139Small hand (HP:0200055)1.73656662
140Absent thumb (HP:0009777)1.72669369
141Congenital, generalized hypertrichosis (HP:0004540)1.72643985
142Abnormality of the ileum (HP:0001549)1.70839687
143Aganglionic megacolon (HP:0002251)1.70810716
144Disproportionate short-trunk short stature (HP:0003521)1.70286198
145Ulnar bowing (HP:0003031)1.69904660
146Chorioretinal atrophy (HP:0000533)1.69127944
147Choanal stenosis (HP:0000452)1.68863616
148Bony spicule pigmentary retinopathy (HP:0007737)1.68753111
149Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67707592
150Progressive sensorineural hearing impairment (HP:0000408)1.66564519
151Aplasia/Hypoplasia of the macula (HP:0008059)1.66554552
152Dandy-Walker malformation (HP:0001305)1.66535530
153Generalized tonic-clonic seizures (HP:0002069)1.66471130
154Cervical subluxation (HP:0003308)1.66277882
155Hypoplastic ischia (HP:0003175)1.65998864
156Squamous cell carcinoma (HP:0002860)1.65667453
157Broad foot (HP:0001769)1.64070486
158Amelogenesis imperfecta (HP:0000705)1.63082145
159Mesangial abnormality (HP:0001966)1.62846832
160Colon cancer (HP:0003003)1.62219841
161Attenuation of retinal blood vessels (HP:0007843)1.61789654
162Molar tooth sign on MRI (HP:0002419)1.61334338
163Abnormality of midbrain morphology (HP:0002418)1.61334338
164Patellar aplasia (HP:0006443)1.61085555
165Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.60927872
166Short foot (HP:0001773)1.60529394
167Aplasia/Hypoplasia of the patella (HP:0006498)1.59339565
168Delayed gross motor development (HP:0002194)1.59144542
169Bulbous nose (HP:0000414)1.58644271
170Aplasia/Hypoplasia of the lens (HP:0008063)1.57666114
171Astigmatism (HP:0000483)1.57168925
172Aplasia/Hypoplasia of the tibia (HP:0005772)1.57161144

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.67771549
2MAPK154.16915682
3DDR23.50087434
4MAP3K63.46238230
5NTRK33.21098489
6FRK3.09036872
7EPHA42.99686537
8PINK12.89943491
9BMPR1B2.89674756
10DAPK12.72825307
11MYLK2.45803552
12TYRO32.43383796
13CASK2.38670318
14UHMK12.22431536
15ACVR1B2.22241077
16AKT32.21434930
17ZAK2.05924408
18MAP3K41.94958875
19PRKD31.93011356
20FGR1.92572218
21GRK71.89471770
22TGFBR11.88718116
23PNCK1.87867157
24LIMK11.86940209
25MATK1.86931048
26MAP3K91.86779907
27MAP2K71.79618536
28PRKD21.77154954
29MAP3K111.76721163
30YES11.72899541
31PRPF4B1.68814952
32WNK41.68423207
33EPHB21.58623817
34MAP4K21.56207696
35NTRK21.55311888
36NEK21.52175001
37PAK31.51768074
38CDC42BPA1.47774204
39CDK121.46508395
40NUAK11.34788830
41ADRBK11.30103104
42ERBB41.28681401
43CDK71.26492363
44TAF11.23067017
45PDGFRA1.21494947
46TRIM281.18927731
47LATS21.17537396
48BCR1.17414509
49CSNK1A1L1.15415918
50INSRR1.14975855
51CAMK1G1.13341882
52TLK11.12761002
53PTK21.10518030
54DYRK1B1.09317889
55PHKG11.08096263
56PHKG21.08096263
57PAK21.07834295
58DYRK21.05511308
59MKNK11.03353193
60MARK11.01947844
61CAMK1D1.00989193
62CHEK21.00423467
63WEE11.00361760
64PLK40.99636570
65TIE10.97581777
66PDK30.97356380
67PDK40.97356380
68CSK0.94756410
69PLK30.94560000
70SIK20.93503088
71CSNK1G20.93308528
72ABL20.92951448
73CSNK1G10.91514182
74CAMK2B0.91394995
75STK380.89248624
76VRK20.86924059
77MAPK130.85480378
78BRSK20.83983351
79CSNK1G30.83949652
80BMX0.83924709
81NEK90.83320396
82DYRK30.81635425
83MAPKAPK50.80828992
84CAMK2A0.80595826
85PLK20.80207472
86PRKCE0.79056292
87DAPK20.77119961
88CHUK0.76498111
89WNK30.76482058
90TGFBR20.75059760
91SGK10.74922165
92TNK20.74576557
93PAK60.73283561
94MET0.71091851
95PRKAA10.71021761
96MARK20.70368754
97MINK10.70089955
98FLT30.69800144
99BRD40.68700962
100BCKDK0.66759690
101PRKCG0.66185076
102RPS6KB10.65921139
103CDK50.64524182
104STK390.63529453
105STK30.63028917
106VRK10.62536462
107GRK10.61477384
108RPS6KC10.59811825
109RPS6KL10.59811825
110PLK10.58713048
111TAOK20.58233031
112MKNK20.57647526
113MAPK100.56938482
114DAPK30.56353461
115OXSR10.55507404
116MUSK0.54156014
117SIK30.53939494
118CAMK2D0.52276490
119GRK50.50134310
120PKN10.49963313
121CAMK10.48516755
122PIM20.46973049
123CDC70.46359628
124ATR0.46247515
125TNIK0.46216154
126MELK0.46006412
127RPS6KA30.45881779
128CDK190.45541819
129PTK2B0.45326315
130PDGFRB0.45291695
131MAP2K40.44067105
132ROCK10.43762041
133CDK80.43376348
134STK160.43287430
135MAPKAPK30.42732393
136CDK180.42694948
137HIPK20.42540960
138FER0.42455670
139CAMK2G0.42203996
140MARK30.41576450
141CDK150.41354613
142PIK3CA0.40493902
143RPS6KA60.40485763
144MAPK140.40411667
145ERBB30.40392981
146NTRK10.40379761
147GSK3B0.40356671
148LATS10.39689188
149PRKCI0.39136729
150CDK20.39085156
151RIPK40.38200562
152ADRBK20.37597585
153CDK11A0.37051770
154FES0.34318345
155CDK10.33530551
156RAF10.33302223
157GSK3A0.32810357
158TRPM70.32732442
159MTOR0.31634370
160PRKCZ0.31205525
161CHEK10.31201514
162ATM0.30993223
163SGK20.30329388
164MAPK70.29996662
165PDK20.29714897
166STK38L0.29541798

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.62779913
2Fatty acid biosynthesis_Homo sapiens_hsa000612.88277743
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.81193466
4Selenocompound metabolism_Homo sapiens_hsa004502.57900745
5Synaptic vesicle cycle_Homo sapiens_hsa047212.55326331
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.48803754
7Phototransduction_Homo sapiens_hsa047442.32369441
8Amphetamine addiction_Homo sapiens_hsa050312.29950269
9Olfactory transduction_Homo sapiens_hsa047402.18746033
10GABAergic synapse_Homo sapiens_hsa047272.11761905
11Protein export_Homo sapiens_hsa030602.11389137
12Morphine addiction_Homo sapiens_hsa050322.10280844
13Long-term potentiation_Homo sapiens_hsa047202.08806497
14Circadian rhythm_Homo sapiens_hsa047101.97997002
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95637317
16Circadian entrainment_Homo sapiens_hsa047131.95261893
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.94269286
18Glutamatergic synapse_Homo sapiens_hsa047241.93841514
19Oxidative phosphorylation_Homo sapiens_hsa001901.91778953
20Taste transduction_Homo sapiens_hsa047421.85798328
21Mismatch repair_Homo sapiens_hsa034301.82365927
22Insulin secretion_Homo sapiens_hsa049111.75842887
23Base excision repair_Homo sapiens_hsa034101.75767203
24Fanconi anemia pathway_Homo sapiens_hsa034601.66978089
25Dopaminergic synapse_Homo sapiens_hsa047281.66646052
26RNA polymerase_Homo sapiens_hsa030201.65042435
27mRNA surveillance pathway_Homo sapiens_hsa030151.59900821
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59573783
29ECM-receptor interaction_Homo sapiens_hsa045121.55956246
30Hedgehog signaling pathway_Homo sapiens_hsa043401.55067993
31Huntingtons disease_Homo sapiens_hsa050161.44735027
32Oocyte meiosis_Homo sapiens_hsa041141.44136256
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42126852
34mTOR signaling pathway_Homo sapiens_hsa041501.40774659
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.40607157
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39928200
37Wnt signaling pathway_Homo sapiens_hsa043101.37047893
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32508106
39Collecting duct acid secretion_Homo sapiens_hsa049661.31024906
40Long-term depression_Homo sapiens_hsa047301.27632983
41Serotonergic synapse_Homo sapiens_hsa047261.27506257
42Parkinsons disease_Homo sapiens_hsa050121.26622093
43Calcium signaling pathway_Homo sapiens_hsa040201.24571817
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.24479009
45Lysosome_Homo sapiens_hsa041421.23819362
46Cardiac muscle contraction_Homo sapiens_hsa042601.23758904
47Tryptophan metabolism_Homo sapiens_hsa003801.23598457
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21698438
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20510485
50Butanoate metabolism_Homo sapiens_hsa006501.20001499
51ErbB signaling pathway_Homo sapiens_hsa040121.17697295
52Steroid biosynthesis_Homo sapiens_hsa001001.15712731
53Salivary secretion_Homo sapiens_hsa049701.11195072
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11125666
55Cocaine addiction_Homo sapiens_hsa050301.09599937
56Dorso-ventral axis formation_Homo sapiens_hsa043201.08938939
57Hippo signaling pathway_Homo sapiens_hsa043901.07230056
58Oxytocin signaling pathway_Homo sapiens_hsa049211.04861034
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.04442864
60Cholinergic synapse_Homo sapiens_hsa047251.04272554
61Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03710826
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02989476
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01713822
64Gap junction_Homo sapiens_hsa045401.01512383
65Type II diabetes mellitus_Homo sapiens_hsa049301.01165179
66Protein digestion and absorption_Homo sapiens_hsa049741.00698838
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99314139
68Propanoate metabolism_Homo sapiens_hsa006400.99175640
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98550930
70cAMP signaling pathway_Homo sapiens_hsa040240.97965272
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97202528
72Renin secretion_Homo sapiens_hsa049240.95777978
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94378397
74Linoleic acid metabolism_Homo sapiens_hsa005910.93396028
75RNA degradation_Homo sapiens_hsa030180.92938789
76Proteasome_Homo sapiens_hsa030500.92428807
77Caffeine metabolism_Homo sapiens_hsa002320.91934281
78Nucleotide excision repair_Homo sapiens_hsa034200.91734876
79Choline metabolism in cancer_Homo sapiens_hsa052310.91480045
80Estrogen signaling pathway_Homo sapiens_hsa049150.90977263
81Basal cell carcinoma_Homo sapiens_hsa052170.90759788
82Nitrogen metabolism_Homo sapiens_hsa009100.90066915
83GnRH signaling pathway_Homo sapiens_hsa049120.89533945
84Alzheimers disease_Homo sapiens_hsa050100.89234854
85Ether lipid metabolism_Homo sapiens_hsa005650.88162025
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87178612
87Sulfur metabolism_Homo sapiens_hsa009200.86746597
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85972486
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85614090
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84738634
91Notch signaling pathway_Homo sapiens_hsa043300.82867554
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82511369
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81358138
94Glucagon signaling pathway_Homo sapiens_hsa049220.80691323
95Axon guidance_Homo sapiens_hsa043600.80311785
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79676374
97Fructose and mannose metabolism_Homo sapiens_hsa000510.78067065
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.77911047
99One carbon pool by folate_Homo sapiens_hsa006700.76873029
100Gastric acid secretion_Homo sapiens_hsa049710.75808542
101MAPK signaling pathway_Homo sapiens_hsa040100.75794369
102Sulfur relay system_Homo sapiens_hsa041220.75331249
103RNA transport_Homo sapiens_hsa030130.74521460
104Melanoma_Homo sapiens_hsa052180.72982182
105Vitamin B6 metabolism_Homo sapiens_hsa007500.72778724
106Melanogenesis_Homo sapiens_hsa049160.72502113
107Colorectal cancer_Homo sapiens_hsa052100.72347701
108Sphingolipid metabolism_Homo sapiens_hsa006000.71402362
109DNA replication_Homo sapiens_hsa030300.71359603
110Dilated cardiomyopathy_Homo sapiens_hsa054140.71204678
111Ovarian steroidogenesis_Homo sapiens_hsa049130.68767777
112Alcoholism_Homo sapiens_hsa050340.67277121
113Vibrio cholerae infection_Homo sapiens_hsa051100.66533755
114Non-homologous end-joining_Homo sapiens_hsa034500.65128524
115Glioma_Homo sapiens_hsa052140.65025025
116Basal transcription factors_Homo sapiens_hsa030220.62514727
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61893012
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61815294
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61596995
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60503866
121Glutathione metabolism_Homo sapiens_hsa004800.60354465
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59694514
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58456756
124Metabolic pathways_Homo sapiens_hsa011000.57125838
125Homologous recombination_Homo sapiens_hsa034400.56170989
126Purine metabolism_Homo sapiens_hsa002300.55549255
127Spliceosome_Homo sapiens_hsa030400.54966165
128Chemical carcinogenesis_Homo sapiens_hsa052040.52608512
129Insulin signaling pathway_Homo sapiens_hsa049100.51852440
130VEGF signaling pathway_Homo sapiens_hsa043700.51159582
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50994538
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50778329
133Peroxisome_Homo sapiens_hsa041460.50190783
134Mineral absorption_Homo sapiens_hsa049780.49690119
135TGF-beta signaling pathway_Homo sapiens_hsa043500.49277705
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49172673
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48524309
138Pyrimidine metabolism_Homo sapiens_hsa002400.48447255
139Focal adhesion_Homo sapiens_hsa045100.48417234
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48143036
141Ras signaling pathway_Homo sapiens_hsa040140.46986879
142Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46271471
143Bladder cancer_Homo sapiens_hsa052190.46036504
144N-Glycan biosynthesis_Homo sapiens_hsa005100.44870473
145Adherens junction_Homo sapiens_hsa045200.44242096
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43810136
147Cell cycle_Homo sapiens_hsa041100.43799329
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43766035
149Tight junction_Homo sapiens_hsa045300.43529796
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42851157
151Proteoglycans in cancer_Homo sapiens_hsa052050.42533599
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41135927
153Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40888509
154Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40818302
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40737498
156Vascular smooth muscle contraction_Homo sapiens_hsa042700.40557009
157p53 signaling pathway_Homo sapiens_hsa041150.38205620
158Lysine degradation_Homo sapiens_hsa003100.37545225

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