ARMC10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.95449428
2ribosomal small subunit assembly (GO:0000028)4.97729945
3viral transcription (GO:0019083)4.47256492
4DNA unwinding involved in DNA replication (GO:0006268)4.43749937
5fucose catabolic process (GO:0019317)4.43735516
6L-fucose metabolic process (GO:0042354)4.43735516
7L-fucose catabolic process (GO:0042355)4.43735516
8translational termination (GO:0006415)4.36416895
9maturation of SSU-rRNA (GO:0030490)4.35620540
10neuronal stem cell maintenance (GO:0097150)4.34459498
11membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.30164514
12nephron epithelium morphogenesis (GO:0072088)4.19647831
13nephron tubule morphogenesis (GO:0072078)4.19647831
14DNA strand elongation involved in DNA replication (GO:0006271)4.06958514
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.00004343
16translational elongation (GO:0006414)3.97621493
17dopamine biosynthetic process (GO:0042416)3.97594886
18DNA strand elongation (GO:0022616)3.95892315
19telomere maintenance via semi-conservative replication (GO:0032201)3.93327776
20response to pheromone (GO:0019236)3.91959064
21cotranslational protein targeting to membrane (GO:0006613)3.87675336
22protein targeting to ER (GO:0045047)3.87290611
23DNA deamination (GO:0045006)3.86992192
24positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.86811621
25formation of translation preinitiation complex (GO:0001731)3.84689856
26protein import into peroxisome matrix (GO:0016558)3.82401040
27membrane repolarization during action potential (GO:0086011)3.81114433
28neuron remodeling (GO:0016322)3.77028894
29DNA replication initiation (GO:0006270)3.76687308
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.76213473
31ribosomal small subunit biogenesis (GO:0042274)3.70434685
32translational initiation (GO:0006413)3.67309408
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.66021013
34regulation of histone phosphorylation (GO:0033127)3.63745401
35protein localization to kinetochore (GO:0034501)3.62821302
36mitotic metaphase plate congression (GO:0007080)3.58847484
37protein localization to endoplasmic reticulum (GO:0070972)3.58282638
38toxin metabolic process (GO:0009404)3.57706158
39telomere maintenance via recombination (GO:0000722)3.54048817
40kynurenine metabolic process (GO:0070189)3.51554298
41kinetochore organization (GO:0051383)3.50433184
42folic acid-containing compound biosynthetic process (GO:0009396)3.50294648
43mitotic recombination (GO:0006312)3.47872896
44viral life cycle (GO:0019058)3.46383351
45tryptophan catabolic process (GO:0006569)3.45840508
46indole-containing compound catabolic process (GO:0042436)3.45840508
47indolalkylamine catabolic process (GO:0046218)3.45840508
48mitotic nuclear envelope disassembly (GO:0007077)3.45777770
49chromatin remodeling at centromere (GO:0031055)3.42688906
50CENP-A containing nucleosome assembly (GO:0034080)3.40178276
51nuclear pore organization (GO:0006999)3.39474695
52ribosomal large subunit biogenesis (GO:0042273)3.37330171
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.36131350
54cellular protein complex disassembly (GO:0043624)3.34520791
55neuron fate determination (GO:0048664)3.33287795
56peristalsis (GO:0030432)3.32047970
57potassium ion export (GO:0071435)3.31041520
58neuronal action potential (GO:0019228)3.30919553
59metaphase plate congression (GO:0051310)3.30132280
60regulation of dopamine secretion (GO:0014059)3.28917311
61kinetochore assembly (GO:0051382)3.26869879
62histone-serine phosphorylation (GO:0035404)3.26318086
63positive regulation of gastrulation (GO:2000543)3.26023669
64positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.24832117
65cell morphogenesis involved in neuron differentiation (GO:0048667)3.24831521
66alkaloid metabolic process (GO:0009820)3.23711041
67DNA replication-independent nucleosome organization (GO:0034724)3.22825688
68DNA replication-independent nucleosome assembly (GO:0006336)3.22825688
69positive regulation of CREB transcription factor activity (GO:0032793)3.21943066
70nuclear envelope disassembly (GO:0051081)3.19677997
71membrane disassembly (GO:0030397)3.19677997
72regulation of helicase activity (GO:0051095)3.18835401
73growth hormone secretion (GO:0030252)3.18354509
74protein complex disassembly (GO:0043241)3.17935526
75negative regulation of RNA splicing (GO:0033119)3.17933581
76primary amino compound metabolic process (GO:1901160)3.16334379
77DNA replication-dependent nucleosome organization (GO:0034723)3.15284915
78DNA replication-dependent nucleosome assembly (GO:0006335)3.15284915
79urinary tract smooth muscle contraction (GO:0014848)3.15237322
80nuclear-transcribed mRNA catabolic process (GO:0000956)3.14906473
81telomere maintenance via telomere lengthening (GO:0010833)3.14881656
82nonmotile primary cilium assembly (GO:0035058)3.14667599
83protein localization to chromosome, centromeric region (GO:0071459)3.13858416
84DNA replication checkpoint (GO:0000076)3.11871475
85ribonucleoprotein complex biogenesis (GO:0022613)3.10850890
86phosphatidylinositol acyl-chain remodeling (GO:0036149)3.10485571
87macroautophagy (GO:0016236)3.06352392
88IMP biosynthetic process (GO:0006188)3.06022819
89membrane repolarization (GO:0086009)3.05057482
90chaperone-mediated protein complex assembly (GO:0051131)3.04328430
91NAD biosynthetic process (GO:0009435)3.03177220
92negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02829592
93nucleotide-excision repair, DNA gap filling (GO:0006297)3.02505597
94nuclear pore complex assembly (GO:0051292)3.01539792
95indolalkylamine metabolic process (GO:0006586)3.01262084
96macromolecular complex disassembly (GO:0032984)3.00819159
97somite rostral/caudal axis specification (GO:0032525)3.00775173
98mRNA catabolic process (GO:0006402)3.00562803
99positive regulation of fatty acid beta-oxidation (GO:0032000)3.00090670
100DNA duplex unwinding (GO:0032508)3.00050500
101spinal cord motor neuron differentiation (GO:0021522)2.99498174
102midbrain development (GO:0030901)2.99352350
103serotonin metabolic process (GO:0042428)2.99215848
104DNA geometric change (GO:0032392)2.97667194
105cellular ketone body metabolic process (GO:0046950)2.97442018
106establishment of chromosome localization (GO:0051303)2.97181895
107deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95251117
108RNA catabolic process (GO:0006401)2.94051328
109sulfation (GO:0051923)2.92731771
110renal tubule morphogenesis (GO:0061333)2.92450995
111establishment of protein localization to mitochondrial membrane (GO:0090151)2.91779409
112ubiquinone biosynthetic process (GO:0006744)2.91703717
113nucleobase biosynthetic process (GO:0046112)2.91461180
114attachment of spindle microtubules to kinetochore (GO:0008608)2.91333853
115establishment of integrated proviral latency (GO:0075713)2.90867638
116postsynaptic membrane organization (GO:0001941)2.90590666
117neural tube formation (GO:0001841)2.90318920
118mitotic chromosome condensation (GO:0007076)2.89929489
119axon ensheathment in central nervous system (GO:0032291)2.87806460
120central nervous system myelination (GO:0022010)2.87806460
121tryptophan metabolic process (GO:0006568)2.87435543
122negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87291730
123telencephalon development (GO:0021537)2.87233342
124positive regulation of triglyceride biosynthetic process (GO:0010867)2.86514534
125epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85989871
126viral mRNA export from host cell nucleus (GO:0046784)2.85541139
127mitotic sister chromatid cohesion (GO:0007064)2.84320670
128cochlea development (GO:0090102)2.84158365
129indole-containing compound metabolic process (GO:0042430)2.84033990
130sequestering of actin monomers (GO:0042989)2.82309130
131negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82130452
132negative regulation of sister chromatid segregation (GO:0033046)2.82130452
133negative regulation of mitotic sister chromatid separation (GO:2000816)2.82130452
134negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82130452
135ubiquinone metabolic process (GO:0006743)2.81915306
136ribosome biogenesis (GO:0042254)2.81892373
137regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81820708
138cilium or flagellum-dependent cell motility (GO:0001539)2.81554630
139negative regulation of leukocyte chemotaxis (GO:0002689)2.81121447
140rRNA processing (GO:0006364)2.80860144
141dorsal/ventral neural tube patterning (GO:0021904)2.80273373
142negative regulation of chromosome segregation (GO:0051985)2.79991846
143positive regulation of sodium ion transmembrane transport (GO:1902307)2.79483472
144spindle assembly checkpoint (GO:0071173)2.79100856
145chromatin assembly or disassembly (GO:0006333)2.79046479
146histone exchange (GO:0043486)2.78110540
147IMP metabolic process (GO:0046040)2.76946011
148ATP-dependent chromatin remodeling (GO:0043044)2.76627564
149negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76611188
150translation (GO:0006412)2.76427126
151mitotic spindle assembly checkpoint (GO:0007094)2.76401689
152regulation of histone H3-K9 methylation (GO:0051570)2.76382118
153kidney morphogenesis (GO:0060993)2.76239810
154negative regulation of histone methylation (GO:0031061)2.74838555
155positive regulation of embryonic development (GO:0040019)2.74704938
156mRNA splicing, via spliceosome (GO:0000398)2.73675532
157RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.73675532
158RNA splicing, via transesterification reactions (GO:0000375)2.73399084
159negative regulation of interleukin-1 beta production (GO:0032691)2.72349649
160catechol-containing compound biosynthetic process (GO:0009713)2.72219875
161catecholamine biosynthetic process (GO:0042423)2.72219875
162synaptic vesicle endocytosis (GO:0048488)2.72219232
163intracellular protein transmembrane import (GO:0044743)2.71655460
164fucosylation (GO:0036065)2.71424016
165rRNA metabolic process (GO:0016072)2.71339193
166telomere maintenance (GO:0000723)2.71154547
167phosphatidylserine acyl-chain remodeling (GO:0036150)2.70471612
168mismatch repair (GO:0006298)2.70028915
169telomere organization (GO:0032200)2.69917192
170embryonic axis specification (GO:0000578)2.69515729
171alanine transport (GO:0032328)2.69371794
172cornea development in camera-type eye (GO:0061303)2.69266789
173neuron cell-cell adhesion (GO:0007158)2.69071191
174dosage compensation (GO:0007549)2.68773847
175somite development (GO:0061053)2.68389734
176cysteine metabolic process (GO:0006534)2.68297529
177somatic hypermutation of immunoglobulin genes (GO:0016446)2.68296154
178somatic diversification of immune receptors via somatic mutation (GO:0002566)2.68296154
179termination of RNA polymerase II transcription (GO:0006369)2.67679842
180regulation of nuclear cell cycle DNA replication (GO:0033262)2.67519310
181translesion synthesis (GO:0019985)2.66902985
182sister chromatid segregation (GO:0000819)2.66648744
183spliceosomal snRNP assembly (GO:0000387)2.65817512
184neuron maturation (GO:0042551)2.65717915
185mitotic spindle checkpoint (GO:0071174)2.65216644
186spindle checkpoint (GO:0031577)2.65027182
187mitochondrial respiratory chain complex I assembly (GO:0032981)2.64188509
188NADH dehydrogenase complex assembly (GO:0010257)2.64188509
189mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64188509
190positive regulation of action potential (GO:0045760)2.63366799
191ketone body metabolic process (GO:1902224)2.62806330
192transmission of nerve impulse (GO:0019226)2.62677126
193membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.62552505
194startle response (GO:0001964)2.62237548
195phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.61842384
196positive regulation of growth hormone secretion (GO:0060124)2.60810570
197cellular response to cholesterol (GO:0071397)2.59910398
198hindbrain development (GO:0030902)2.57648105
199negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.57259286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.10304212
2EZH2_22144423_ChIP-Seq_EOC_Human5.16205457
3ZNF274_21170338_ChIP-Seq_K562_Hela5.09025900
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.11113428
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.75745975
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48479149
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.41842957
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30493272
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19074547
10VDR_22108803_ChIP-Seq_LS180_Human3.08457300
11GBX2_23144817_ChIP-Seq_PC3_Human2.89173868
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86659732
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.78582163
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67184492
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65089186
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.63930371
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.62603951
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62357743
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59107380
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49152559
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38298035
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.36152220
23XRN2_22483619_ChIP-Seq_HELA_Human2.34832477
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32994489
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32446118
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.28965753
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22255231
28VDR_23849224_ChIP-Seq_CD4+_Human2.21272066
29MYC_22102868_ChIP-Seq_BL_Human2.11448756
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09974662
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09510692
32CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09101858
33EED_16625203_ChIP-ChIP_MESCs_Mouse2.07124150
34CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05664765
35CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04932932
36BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04883477
37EZH2_27304074_Chip-Seq_ESCs_Mouse2.03933033
38E2F1_21310950_ChIP-Seq_MCF-7_Human2.02548116
39DROSHA_22980978_ChIP-Seq_HELA_Human1.99863722
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99096128
41FOXP3_21729870_ChIP-Seq_TREG_Human1.96539785
42REST_21632747_ChIP-Seq_MESCs_Mouse1.96094553
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95563814
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94408512
45CIITA_25753668_ChIP-Seq_RAJI_Human1.94060934
46JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93505843
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93167820
48TTF2_22483619_ChIP-Seq_HELA_Human1.91508008
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89527532
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85342875
51DCP1A_22483619_ChIP-Seq_HELA_Human1.81964671
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81918323
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81841015
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81818715
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.81697318
56AR_21909140_ChIP-Seq_LNCAP_Human1.80884202
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.77115294
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75469110
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75379340
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75282554
61GABP_19822575_ChIP-Seq_HepG2_Human1.74641759
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74243243
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73702181
64ELK1_19687146_ChIP-ChIP_HELA_Human1.72977672
65JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72460166
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71031802
67AR_21572438_ChIP-Seq_LNCaP_Human1.69940817
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69578290
69* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68640306
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63664012
71NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60913935
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.59130130
73EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58955613
74RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58955613
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.58700564
76FUS_26573619_Chip-Seq_HEK293_Human1.58686310
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57968214
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57087793
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57087793
80* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54717583
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54234316
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54190496
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51334751
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50674456
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47820168
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47652736
87TP53_16413492_ChIP-PET_HCT116_Human1.46139189
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46131593
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45578937
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44812992
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44499359
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43656315
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43087332
94P300_19829295_ChIP-Seq_ESCs_Human1.42881215
95KDM5A_27292631_Chip-Seq_BREAST_Human1.42082358
96EWS_26573619_Chip-Seq_HEK293_Human1.41589513
97* ER_23166858_ChIP-Seq_MCF-7_Human1.41442609
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40324284
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.38625570
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38288279
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.34581340
102SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33127107
103SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32817078
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30673768
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.29451579
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28775075
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28331322
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28204898
109AR_25329375_ChIP-Seq_VCAP_Human1.28087786
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25311981
111VDR_21846776_ChIP-Seq_THP-1_Human1.24178207
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.23348808
113FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23348808
114BCAT_22108803_ChIP-Seq_LS180_Human1.23249504
115RNF2_27304074_Chip-Seq_NSC_Mouse1.22264420
116TFEB_21752829_ChIP-Seq_HELA_Human1.21712647
117* STAT3_23295773_ChIP-Seq_U87_Human1.20546373
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20330711
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20295999
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20167684
121TP53_22573176_ChIP-Seq_HFKS_Human1.19432261
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19118114
123SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19093446
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18210752
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17911857
126NOTCH1_21737748_ChIP-Seq_TLL_Human1.16815831
127POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16293490
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16008838
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15351072
130SPI1_23547873_ChIP-Seq_NB4_Human1.15106736
131KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15008263
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14922374
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13831757
134YY1_21170310_ChIP-Seq_MESCs_Mouse1.13804238
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13532988
136MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13515333
137IRF1_19129219_ChIP-ChIP_H3396_Human1.12699088
138POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11732530
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11032996
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09574551
141SRF_21415370_ChIP-Seq_HL-1_Mouse1.08745302
142PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08660502
143ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07353855
144ERA_21632823_ChIP-Seq_H3396_Human1.07069449
145TAF15_26573619_Chip-Seq_HEK293_Human1.06729039
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06238842
147RUNX2_22187159_ChIP-Seq_PCA_Human1.06066359
148IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05825089
149PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05413801
150MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05026944
151CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04643125
152CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04571529
153NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04456846
154IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02517948
155SMAD3_21741376_ChIP-Seq_EPCs_Human1.02256768
156TAF2_19829295_ChIP-Seq_ESCs_Human1.02073535
157GATA1_22025678_ChIP-Seq_K562_Human1.01864088
158HOXB7_26014856_ChIP-Seq_BT474_Human1.01087573
159SOX2_19829295_ChIP-Seq_ESCs_Human1.00805323
160NANOG_19829295_ChIP-Seq_ESCs_Human1.00805323
161MYC_18940864_ChIP-ChIP_HL60_Human1.00164819
162SCL_19346495_ChIP-Seq_HPC-7_Human0.99839269
163NANOG_21062744_ChIP-ChIP_HESCs_Human0.99645169
164MYC_19829295_ChIP-Seq_ESCs_Human0.99194273
165SMAD4_21799915_ChIP-Seq_A2780_Human0.98328462
166TCF4_23295773_ChIP-Seq_U87_Human0.97522546
167EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97313801
168SMAD4_21741376_ChIP-Seq_EPCs_Human0.97087769
169RXR_22108803_ChIP-Seq_LS180_Human0.96630669
170RING1B_27294783_Chip-Seq_ESCs_Mouse0.96301240
171FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95846664
172TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95575956
173* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95129588
174CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95080916
175PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94825329
176MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94250528
177TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93520216
178* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92469914
179TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92050587
180OCT1_27270436_Chip-Seq_PROSTATE_Human0.91654622
181FLI1_21867929_ChIP-Seq_TH2_Mouse0.91640117
182ARNT_22903824_ChIP-Seq_MCF-7_Human0.90652997
183TP53_20018659_ChIP-ChIP_R1E_Mouse0.89740634
184GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89725190
185ELK1_22589737_ChIP-Seq_MCF10A_Human0.89213538
186ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87117730
187* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86349619
188NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85972208
189SALL1_21062744_ChIP-ChIP_HESCs_Human0.85954109
190E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85664574
191MYB_26560356_Chip-Seq_TH2_Human0.85433902
192CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84101041
193* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83636487

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.73218958
2MP0003693_abnormal_embryo_hatching4.52336960
3MP0004957_abnormal_blastocyst_morpholog3.63273646
4MP0010094_abnormal_chromosome_stability3.53893993
5MP0003077_abnormal_cell_cycle3.32876849
6MP0005377_hearing/vestibular/ear_phenot3.22675119
7MP0003878_abnormal_ear_physiology3.22675119
8MP0003111_abnormal_nucleus_morphology3.21387982
9MP0001485_abnormal_pinna_reflex2.87219758
10MP0008057_abnormal_DNA_replication2.73466101
11MP0008007_abnormal_cellular_replicative2.67260401
12MP0008058_abnormal_DNA_repair2.67082840
13MP0009379_abnormal_foot_pigmentation2.55608521
14MP0010352_gastrointestinal_tract_polyps2.40096689
15MP0002396_abnormal_hematopoietic_system2.32310644
16MP0003195_calcinosis2.28611275
17MP0008875_abnormal_xenobiotic_pharmacok2.16189762
18MP0000569_abnormal_digit_pigmentation2.14293922
19MP0004742_abnormal_vestibular_system2.13551266
20MP0004885_abnormal_endolymph2.13367626
21MP0003123_paternal_imprinting2.06651059
22MP0004142_abnormal_muscle_tone2.03453796
23MP0002102_abnormal_ear_morphology2.02811335
24MP0000490_abnormal_crypts_of1.99942484
25MP0008932_abnormal_embryonic_tissue1.98680802
26MP0001501_abnormal_sleep_pattern1.98266096
27MP0002735_abnormal_chemical_nociception1.96877535
28MP0002277_abnormal_respiratory_mucosa1.95972062
29MP0003763_abnormal_thymus_physiology1.92363451
30MP0009745_abnormal_behavioral_response1.89198333
31MP0005551_abnormal_eye_electrophysiolog1.88985386
32MP0001730_embryonic_growth_arrest1.88483078
33MP0000350_abnormal_cell_proliferation1.86742020
34MP0004808_abnormal_hematopoietic_stem1.77769040
35MP0009046_muscle_twitch1.77547522
36MP0010030_abnormal_orbit_morphology1.76550730
37MP0002064_seizures1.68650199
38MP0006292_abnormal_olfactory_placode1.68484940
39MP0001968_abnormal_touch/_nociception1.66644176
40MP0003959_abnormal_lean_body1.65939628
41MP0010307_abnormal_tumor_latency1.61727181
42MP0000026_abnormal_inner_ear1.60588888
43MP0002572_abnormal_emotion/affect_behav1.59898892
44MP0001697_abnormal_embryo_size1.55287709
45MP0002272_abnormal_nervous_system1.54056280
46MP0002067_abnormal_sensory_capabilities1.53627446
47MP0003121_genomic_imprinting1.53326880
48MP0008872_abnormal_physiological_respon1.47977690
49MP0002084_abnormal_developmental_patter1.46624731
50MP0000631_abnormal_neuroendocrine_gland1.46534028
51MP0001486_abnormal_startle_reflex1.46223788
52MP0004264_abnormal_extraembryonic_tissu1.45304863
53MP0005084_abnormal_gallbladder_morpholo1.44761537
54MP0006054_spinal_hemorrhage1.44576148
55MP0005380_embryogenesis_phenotype1.44275608
56MP0001672_abnormal_embryogenesis/_devel1.44275608
57MP0002085_abnormal_embryonic_tissue1.44209322
58MP0002063_abnormal_learning/memory/cond1.42759821
59MP0005171_absent_coat_pigmentation1.42312194
60MP0004147_increased_porphyrin_level1.39828475
61MP0001529_abnormal_vocalization1.39177825
62MP0001293_anophthalmia1.36976683
63MP0002080_prenatal_lethality1.35992027
64MP0000537_abnormal_urethra_morphology1.35023609
65MP0003567_abnormal_fetal_cardiomyocyte1.34976821
66MP0002733_abnormal_thermal_nociception1.34442070
67MP0003880_abnormal_central_pattern1.34199442
68MP0003984_embryonic_growth_retardation1.33290337
69MP0000678_abnormal_parathyroid_gland1.33250137
70MP0002557_abnormal_social/conspecific_i1.33134303
71MP0000703_abnormal_thymus_morphology1.32564777
72MP0002088_abnormal_embryonic_growth/wei1.31297353
73MP0000778_abnormal_nervous_system1.31151235
74MP0002019_abnormal_tumor_incidence1.30891153
75MP0004924_abnormal_behavior1.30337429
76MP0005386_behavior/neurological_phenoty1.30337429
77MP0000313_abnormal_cell_death1.30305336
78MP0005423_abnormal_somatic_nervous1.29973890
79MP0002877_abnormal_melanocyte_morpholog1.29324260
80MP0002928_abnormal_bile_duct1.29062614
81MP0009333_abnormal_splenocyte_physiolog1.28900526
82MP0002736_abnormal_nociception_after1.28070545
83MP0004130_abnormal_muscle_cell1.28056296
84MP0002398_abnormal_bone_marrow1.27771984
85MP0002086_abnormal_extraembryonic_tissu1.25456423
86MP0003890_abnormal_embryonic-extraembry1.25070262
87MP0001970_abnormal_pain_threshold1.22338312
88MP0003635_abnormal_synaptic_transmissio1.22081491
89MP0003786_premature_aging1.21754791
90MP0008877_abnormal_DNA_methylation1.20491041
91MP0004197_abnormal_fetal_growth/weight/1.20452835
92MP0002638_abnormal_pupillary_reflex1.19579043
93MP0001545_abnormal_hematopoietic_system1.18732664
94MP0005397_hematopoietic_system_phenotyp1.18732664
95MP0002282_abnormal_trachea_morphology1.18334490
96MP0005076_abnormal_cell_differentiation1.18071308
97MP0001663_abnormal_digestive_system1.16917462
98MP0003632_abnormal_nervous_system1.16733510
99MP0001905_abnormal_dopamine_level1.16646215
100MP0002734_abnormal_mechanical_nocicepti1.16359517
101MP0003646_muscle_fatigue1.15628425
102MP0000383_abnormal_hair_follicle1.14751326
103MP0003119_abnormal_digestive_system1.12803834
104MP0003011_delayed_dark_adaptation1.10349400
105MP0005195_abnormal_posterior_eye1.10345848
106MP0004043_abnormal_pH_regulation1.10186456
107MP0003137_abnormal_impulse_conducting1.08287863
108MP0002160_abnormal_reproductive_system1.06355529
109MP0004145_abnormal_muscle_electrophysio1.05882542
110MP0008789_abnormal_olfactory_epithelium1.05859534
111MP0001849_ear_inflammation1.05174367
112MP0002876_abnormal_thyroid_physiology1.05145681
113MP0002722_abnormal_immune_system1.04594846
114MP0003638_abnormal_response/metabolism_1.03973156
115MP0000427_abnormal_hair_cycle1.03736565
116MP0004215_abnormal_myocardial_fiber1.03582647
117MP0000685_abnormal_immune_system1.03388026
118MP0002653_abnormal_ependyma_morphology1.01721456
119MP0003315_abnormal_perineum_morphology1.01700138
120MP0001963_abnormal_hearing_physiology1.00259814
121MP0005220_abnormal_exocrine_pancreas0.97796191
122MP0002938_white_spotting0.97639376
123MP0005381_digestive/alimentary_phenotyp0.95824016
124MP0010234_abnormal_vibrissa_follicle0.95325066
125MP0001986_abnormal_taste_sensitivity0.95314220
126MP0000613_abnormal_salivary_gland0.94677160
127MP0000689_abnormal_spleen_morphology0.94003381
128MP0009053_abnormal_anal_canal0.93958657
129MP0005174_abnormal_tail_pigmentation0.93633205
130MP0002429_abnormal_blood_cell0.93577687
131MP0000477_abnormal_intestine_morphology0.93388985
132MP0004133_heterotaxia0.93193923
133MP0002166_altered_tumor_susceptibility0.92580303
134MP0005075_abnormal_melanosome_morpholog0.92478882
135MP0001919_abnormal_reproductive_system0.92059161
136MP0002092_abnormal_eye_morphology0.91321999
137MP0000858_altered_metastatic_potential0.90653912
138MP0000647_abnormal_sebaceous_gland0.90094007
139MP0002752_abnormal_somatic_nervous0.90090702
140MP0000465_gastrointestinal_hemorrhage0.90022148
141MP0000716_abnormal_immune_system0.89000265
142MP0002210_abnormal_sex_determination0.87589202
143MP0000049_abnormal_middle_ear0.86452690
144MP0000955_abnormal_spinal_cord0.86280906
145MP0003183_abnormal_peptide_metabolism0.85222634
146MP0005253_abnormal_eye_physiology0.84669984
147MP0003937_abnormal_limbs/digits/tail_de0.84505180
148MP0001286_abnormal_eye_development0.84386140
149MP0002882_abnormal_neuron_morphology0.83680737
150MP0006276_abnormal_autonomic_nervous0.83666429
151MP0002006_tumorigenesis0.83488846
152MP0001324_abnormal_eye_pigmentation0.83431802
153MP0009278_abnormal_bone_marrow0.83214853
154MP0003283_abnormal_digestive_organ0.82865372
155MP0003943_abnormal_hepatobiliary_system0.82484710
156MP0001145_abnormal_male_reproductive0.81026718
157MP0009672_abnormal_birth_weight0.80322781
158MP0001119_abnormal_female_reproductive0.79231177
159MP0002009_preneoplasia0.78420091
160MP0005503_abnormal_tendon_morphology0.78180167
161MP0010155_abnormal_intestine_physiology0.77308533
162MP0005671_abnormal_response_to0.76852844
163MP0002249_abnormal_larynx_morphology0.76823060
164MP0003941_abnormal_skin_development0.76822428
165MP0005367_renal/urinary_system_phenotyp0.76475665
166MP0000516_abnormal_urinary_system0.76475665
167MP0002229_neurodegeneration0.76412100
168MP0000371_diluted_coat_color0.75803031
169MP0005448_abnormal_energy_balance0.75725080
170MP0002420_abnormal_adaptive_immunity0.75509968
171MP0001944_abnormal_pancreas_morphology0.74999707
172MP0002095_abnormal_skin_pigmentation0.74965885
173MP0001440_abnormal_grooming_behavior0.74272319
174MP0002075_abnormal_coat/hair_pigmentati0.74236885
175MP0001819_abnormal_immune_cell0.73699325
176MP0002751_abnormal_autonomic_nervous0.73575800
177MP0002152_abnormal_brain_morphology0.72946689
178MP0000428_abnormal_craniofacial_morphol0.72276713
179MP0000470_abnormal_stomach_morphology0.71665360
180MP0000566_synostosis0.70809325
181MP0001800_abnormal_humoral_immune0.70168318
182MP0000653_abnormal_sex_gland0.70023146
183MP0000579_abnormal_nail_morphology0.68072368
184MP0000230_abnormal_systemic_arterial0.67847834
185MP0005187_abnormal_penis_morphology0.67829696

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.70856936
2Colon cancer (HP:0003003)4.39487564
3Concave nail (HP:0001598)4.10473282
4Abnormality of midbrain morphology (HP:0002418)4.01319480
5Molar tooth sign on MRI (HP:0002419)4.01319480
6Abnormality of alanine metabolism (HP:0010916)3.85460620
7Hyperalaninemia (HP:0003348)3.85460620
8Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.85460620
9True hermaphroditism (HP:0010459)3.75237365
10Abnormality of cells of the erythroid lineage (HP:0012130)3.72788880
11Global brain atrophy (HP:0002283)3.65491790
12Pancreatic cysts (HP:0001737)3.59176562
13Aplastic anemia (HP:0001915)3.48449311
14Birth length less than 3rd percentile (HP:0003561)3.47740786
15Congenital, generalized hypertrichosis (HP:0004540)3.45599827
16Congenital stationary night blindness (HP:0007642)3.45520581
17Abnormality of the anterior horn cell (HP:0006802)3.42511406
18Degeneration of anterior horn cells (HP:0002398)3.42511406
19Abnormal number of erythroid precursors (HP:0012131)3.41540954
20Pancreatic fibrosis (HP:0100732)3.39418378
21Nephronophthisis (HP:0000090)3.32215892
22Bronchomalacia (HP:0002780)3.27688495
23Large for gestational age (HP:0001520)3.23569169
24Inability to walk (HP:0002540)3.22531183
2511 pairs of ribs (HP:0000878)3.15564209
26Spastic tetraparesis (HP:0001285)3.12664009
27Medulloblastoma (HP:0002885)3.12228115
28Absent/shortened dynein arms (HP:0200106)3.07790400
29Dynein arm defect of respiratory motile cilia (HP:0012255)3.07790400
30Prominent supraorbital ridges (HP:0000336)3.03374389
31Pallor (HP:0000980)3.01294159
32Type II lissencephaly (HP:0007260)3.00628059
33Ependymoma (HP:0002888)2.94598986
34Long nose (HP:0003189)2.92327052
35Limb dystonia (HP:0002451)2.90730598
36Hyperventilation (HP:0002883)2.86862694
37Morphological abnormality of the pyramidal tract (HP:0002062)2.83951694
38Oral leukoplakia (HP:0002745)2.81210891
39Selective tooth agenesis (HP:0001592)2.76578304
40Furrowed tongue (HP:0000221)2.75260522
41Chromsome breakage (HP:0040012)2.73178694
42Absent thumb (HP:0009777)2.70238585
43Abnormal number of incisors (HP:0011064)2.69605607
44Hypoplastic labia majora (HP:0000059)2.69070930
45Tubular atrophy (HP:0000092)2.68908497
46Partial agenesis of the corpus callosum (HP:0001338)2.66959915
47Thrombocytosis (HP:0001894)2.66824649
48Optic nerve coloboma (HP:0000588)2.64114838
49Abnormality of the renal medulla (HP:0100957)2.64104529
50Patellar aplasia (HP:0006443)2.63995513
51Abnormal ciliary motility (HP:0012262)2.63966314
52Myelodysplasia (HP:0002863)2.61662325
53Abnormality of chromosome stability (HP:0003220)2.59929341
54Progressive inability to walk (HP:0002505)2.58741431
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.57628295
56Sclerocornea (HP:0000647)2.57148191
57Mesangial abnormality (HP:0001966)2.53532099
58Macrocytic anemia (HP:0001972)2.51154552
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.49135389
60Aplasia/Hypoplasia of the patella (HP:0006498)2.48578858
61Abnormal respiratory epithelium morphology (HP:0012253)2.46246991
62Abnormal respiratory motile cilium morphology (HP:0005938)2.46246991
63Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45207547
64Abnormality of the preputium (HP:0100587)2.44395461
65Microretrognathia (HP:0000308)2.43901162
66Abnormality of the labia majora (HP:0012881)2.43201093
67Cystic liver disease (HP:0006706)2.42432723
68Protruding tongue (HP:0010808)2.41338927
69Type I transferrin isoform profile (HP:0003642)2.39446530
70Abnormality of the diencephalon (HP:0010662)2.37161098
71Septo-optic dysplasia (HP:0100842)2.36577592
72Neoplasm of the pancreas (HP:0002894)2.36339352
73IgM deficiency (HP:0002850)2.35904922
74Volvulus (HP:0002580)2.34510477
75Ventricular fibrillation (HP:0001663)2.34270372
76Missing ribs (HP:0000921)2.33254044
77Abnormality of the renal cortex (HP:0011035)2.32076097
78Meckel diverticulum (HP:0002245)2.28525303
79Anophthalmia (HP:0000528)2.27840413
80Chronic hepatic failure (HP:0100626)2.25675902
81Ulnar claw (HP:0001178)2.25324334
82Clumsiness (HP:0002312)2.24204950
83Increased nuchal translucency (HP:0010880)2.23757822
84Oligodactyly (hands) (HP:0001180)2.21509080
85Progressive cerebellar ataxia (HP:0002073)2.17539350
86Premature graying of hair (HP:0002216)2.17462426
87Abnormality of the ileum (HP:0001549)2.15939481
88Esophageal atresia (HP:0002032)2.15064398
89Hypoplastic ischia (HP:0003175)2.14124315
90Basal cell carcinoma (HP:0002671)2.14009749
91Rhabdomyosarcoma (HP:0002859)2.13987146
92Male pseudohermaphroditism (HP:0000037)2.13746075
93Small intestinal stenosis (HP:0012848)2.13152321
94Duodenal stenosis (HP:0100867)2.13152321
95Medial flaring of the eyebrow (HP:0010747)2.12966387
96Breast hypoplasia (HP:0003187)2.12657838
97Retinal dysplasia (HP:0007973)2.11569717
98Attenuation of retinal blood vessels (HP:0007843)2.10960472
99Neoplasm of the oral cavity (HP:0100649)2.10039810
100Bone marrow hypocellularity (HP:0005528)2.08414377
101Ectopic kidney (HP:0000086)2.06751207
102Trismus (HP:0000211)2.05392663
103Facial cleft (HP:0002006)2.04844198
104Anencephaly (HP:0002323)2.04536072
105Abnormal respiratory motile cilium physiology (HP:0012261)2.03144442
106Gait imbalance (HP:0002141)2.02843164
107Short 4th metacarpal (HP:0010044)2.02768060
108Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02768060
109Rib fusion (HP:0000902)2.02130690
110Brushfield spots (HP:0001088)2.01596952
111Rough bone trabeculation (HP:0100670)2.01564721
112Atresia of the external auditory canal (HP:0000413)2.00833752
113Breast aplasia (HP:0100783)2.00265552
114Lymphoma (HP:0002665)2.00215766
115Tracheomalacia (HP:0002779)1.99510939
116Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99286339
117Female pseudohermaphroditism (HP:0010458)1.99249260
118Acute lymphatic leukemia (HP:0006721)1.98141108
119Pendular nystagmus (HP:0012043)1.98006343
120Neoplasm of the colon (HP:0100273)1.97498639
121Amaurosis fugax (HP:0100576)1.96436192
122Scrotal hypoplasia (HP:0000046)1.94125058
123Broad metatarsal (HP:0001783)1.93930689
124Abnormal lung lobation (HP:0002101)1.93449950
125Sloping forehead (HP:0000340)1.92848194
126Abnormality of the duodenum (HP:0002246)1.92218224
127Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91834281
128Prolonged QT interval (HP:0001657)1.89540534
129Maternal diabetes (HP:0009800)1.89173334
130Horseshoe kidney (HP:0000085)1.89056422
131Lissencephaly (HP:0001339)1.88792021
132Agnosia (HP:0010524)1.87940130
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.87817676
134Severe muscular hypotonia (HP:0006829)1.86049289
135Congenital hepatic fibrosis (HP:0002612)1.85016473
136Tracheoesophageal fistula (HP:0002575)1.84685516
137Optic nerve hypoplasia (HP:0000609)1.83787083
138Genetic anticipation (HP:0003743)1.83468179
139Poikiloderma (HP:0001029)1.83046675
140Bilateral microphthalmos (HP:0007633)1.79886318
141Abnormality of the carotid arteries (HP:0005344)1.79876352
142Cerebellar dysplasia (HP:0007033)1.79546347
143Abnormality of the ischium (HP:0003174)1.79501915
144Renal duplication (HP:0000075)1.79447252
145Focal motor seizures (HP:0011153)1.79207581
146Proximal placement of thumb (HP:0009623)1.78536864
147Slender long bone (HP:0003100)1.78399975
148Increased corneal curvature (HP:0100692)1.78198642
149Keratoconus (HP:0000563)1.78198642
150Cellular immunodeficiency (HP:0005374)1.77735491
151Malignant gastrointestinal tract tumors (HP:0006749)1.77718236
152Gastrointestinal carcinoma (HP:0002672)1.77718236
153Congenital primary aphakia (HP:0007707)1.77266348
154Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76490629
155Abnormal protein N-linked glycosylation (HP:0012347)1.76490629
156Abnormal protein glycosylation (HP:0012346)1.76490629
157Abnormal glycosylation (HP:0012345)1.76490629
158Prominent metopic ridge (HP:0005487)1.76264925
159Chorioretinal atrophy (HP:0000533)1.76175968
160Supernumerary spleens (HP:0009799)1.75716522
161Deviation of the thumb (HP:0009603)1.75153839
162Triphalangeal thumb (HP:0001199)1.74633704
163Depressed nasal ridge (HP:0000457)1.74190176
164Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73163395
165Supernumerary bones of the axial skeleton (HP:0009144)1.72667695
166Labial hypoplasia (HP:0000066)1.72557971
167Abnormality of the fingertips (HP:0001211)1.72467206
168Abnormality of the pubic bones (HP:0003172)1.72237554
169Prominent nose (HP:0000448)1.71045223
170Abnormality of the metopic suture (HP:0005556)1.70840143
171Spinal muscular atrophy (HP:0007269)1.70703330
172Fibular hypoplasia (HP:0003038)1.70569729
173Biliary tract neoplasm (HP:0100574)1.70192895
174Carpal bone hypoplasia (HP:0001498)1.69152688
175Aplasia/Hypoplasia of the breasts (HP:0010311)1.68996512
176Glioma (HP:0009733)1.68979927
177Abnormality of the vertebral endplates (HP:0005106)1.68840628
178Polydipsia (HP:0001959)1.68490321
179Abnormal drinking behavior (HP:0030082)1.68490321
180Acute myeloid leukemia (HP:0004808)1.68174512
181Aplasia/Hypoplasia of the sternum (HP:0006714)1.68138472
182Hypoplasia of the radius (HP:0002984)1.67764881
183Abnormality of the pancreatic islet cells (HP:0006476)1.66161027
184Abnormality of endocrine pancreas physiology (HP:0012093)1.66161027
185Hypoplasia of the pons (HP:0012110)1.66135083
186Neoplasm of striated muscle (HP:0009728)1.66062086
187Abnormality of T cell physiology (HP:0011840)1.65234907
188Intestinal polyp (HP:0005266)1.63803222
189Thick lower lip vermilion (HP:0000179)1.63041125
190Short middle phalanx of the 5th finger (HP:0004220)1.61879165
191Abnormality of T cells (HP:0002843)1.61460578
192Astrocytoma (HP:0009592)1.61309849
193Abnormality of the astrocytes (HP:0100707)1.61309849

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.45784955
2CDC73.50210074
3BUB13.49939115
4MAPK153.36780802
5ADRBK23.11348258
6BMPR1B3.01449484
7PASK2.96899849
8WNK42.74779525
9WEE12.64772836
10ACVR1B2.56250167
11SRPK12.51100940
12NEK22.48067064
13FLT32.37664509
14RPS6KB22.30723125
15DYRK32.28011860
16NME22.21472055
17CASK2.15494960
18CAMKK22.14011359
19EEF2K2.12457899
20TGFBR12.09957153
21VRK12.09041046
22RPS6KA42.02576655
23MAPK132.01094710
24WNK31.99206876
25TTK1.91891003
26STK161.85988409
27SCYL21.85964992
28BRSK21.85647454
29PLK41.83572846
30MKNK11.78459752
31CDK121.74775551
32MAPKAPK51.69845083
33ATR1.69833704
34MAP3K101.69445241
35DAPK21.69231754
36MARK11.65996937
37EPHA21.65987536
38GRK11.63992198
39NTRK21.61114234
40PLK11.58319201
41CAMK1D1.57931440
42CDK71.54188769
43AURKB1.53624381
44EIF2AK31.44123865
45PKN21.42386036
46EIF2AK11.41359595
47NEK91.38850364
48PINK11.35503131
49ADRBK11.35185437
50TYRO31.29742132
51CAMKK11.26813983
52CHEK21.26151791
53TLK11.25576030
54STK101.24758494
55NLK1.19202236
56MKNK21.18262651
57MAPKAPK31.16683181
58BRD41.16658637
59MAP4K11.15659205
60PLK31.10093047
61TNIK1.09716087
62MAP3K81.08124251
63PRKCG1.07778749
64PKN11.06836165
65CAMK1G1.05180923
66TSSK61.04789071
67LRRK21.02099269
68NTRK31.01568951
69ZAK0.99855391
70CDK40.99581003
71CCNB10.99332260
72CHEK10.98542020
73IRAK40.97296098
74PAK40.96704928
75NEK10.96648499
76BTK0.96558291
77INSRR0.95600446
78MELK0.94509201
79ZAP700.93353564
80HIPK20.89814133
81BRSK10.88433202
82TAOK30.88263202
83AURKA0.87579463
84PIK3CA0.87298287
85OXSR10.85470846
86MAP4K20.84909472
87TEC0.83942030
88JAK30.82495055
89ATM0.82226482
90STK390.79354778
91RPS6KA60.78437704
92CDK60.73649916
93PTK2B0.72568190
94DYRK20.71285468
95CDK80.70887440
96PIM10.70163154
97MAP3K40.69839179
98CDK20.69756956
99PRKCQ0.67797121
100MAP2K10.65949017
101TESK20.65865564
102STK40.65390605
103KIT0.65247653
104PTK60.63085845
105FRK0.62744011
106CAMK40.61566494
107EPHB20.60332501
108CAMK2A0.59821972
109CSNK2A20.57758475
110IRAK10.57735921
111CDK30.56742326
112KDR0.55247860
113UHMK10.53560808
114ERBB30.53325497
115DYRK1B0.52294496
116MET0.50530602
117PIM20.50378869
118STK110.50286763
119CAMK10.50125938
120CSNK2A10.50088039
121CDK90.49734673
122MAP2K40.48966895
123CHUK0.48529258
124CAMK2B0.48476287
125WNK10.48464714
126CLK10.48407948
127PRKCI0.47939940
128TGFBR20.47323572
129RPS6KA50.47193861
130TYK20.46715352
131CDK10.44603797
132MAP2K70.44302036
133ERN10.44163824
134PAK30.44075928
135ALK0.42874182
136MUSK0.41371562
137MTOR0.40586670
138ILK0.40470757
139NME10.39852065
140BRAF0.38963582
141MAPKAPK20.38645313
142PRKCZ0.38097019
143ITK0.37128357
144PRKACA0.36963151
145TRIB30.36169921
146TRPM70.36130124
147PAK10.35080053
148MAP2K20.34443082
149YES10.31934455
150TIE10.30461788
151STK30.30436032
152MAP2K60.29547072
153PHKG20.29304122
154PHKG10.29304122
155NUAK10.28869147
156MAP3K60.27586059
157MAP3K50.27494191
158FGFR30.27164955
159PRKCA0.26025745
160PRKCE0.24677136
161DYRK1A0.24398360
162PDGFRB0.23529829
163GRK70.23142074
164PAK20.22614879
165SIK20.22449902
166PIK3CG0.22008418
167PRKACB0.21968649
168PRKG10.20605545
169OBSCN0.20130166
170MAPK40.17992468
171CAMK2D0.14821133
172CSNK1A10.12924517
173RPS6KA30.12378969
174MAPK30.12137835

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.51281187
2Linoleic acid metabolism_Homo sapiens_hsa005913.89692260
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.87545518
4Mismatch repair_Homo sapiens_hsa034303.83523986
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.74459958
6Ribosome_Homo sapiens_hsa030103.69353705
7Nicotine addiction_Homo sapiens_hsa050333.15644760
8Spliceosome_Homo sapiens_hsa030403.12080051
9Nitrogen metabolism_Homo sapiens_hsa009102.94958627
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.91579784
11Base excision repair_Homo sapiens_hsa034102.85358886
12Butanoate metabolism_Homo sapiens_hsa006502.84494265
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82993479
14RNA transport_Homo sapiens_hsa030132.76611561
15Cell cycle_Homo sapiens_hsa041102.65268023
16Homologous recombination_Homo sapiens_hsa034402.52141042
17RNA polymerase_Homo sapiens_hsa030202.49393476
18Nucleotide excision repair_Homo sapiens_hsa034202.46425488
19Ether lipid metabolism_Homo sapiens_hsa005652.44785863
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.24975658
21Proteasome_Homo sapiens_hsa030502.14234739
22Pyrimidine metabolism_Homo sapiens_hsa002402.10838253
23Non-homologous end-joining_Homo sapiens_hsa034502.04956717
24One carbon pool by folate_Homo sapiens_hsa006702.01395583
25Phototransduction_Homo sapiens_hsa047442.01027529
26Fanconi anemia pathway_Homo sapiens_hsa034601.99083501
27RNA degradation_Homo sapiens_hsa030181.98988339
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82930526
29Basal transcription factors_Homo sapiens_hsa030221.73969236
30p53 signaling pathway_Homo sapiens_hsa041151.72613339
31mRNA surveillance pathway_Homo sapiens_hsa030151.72066488
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71386833
33Tryptophan metabolism_Homo sapiens_hsa003801.69464559
34Caffeine metabolism_Homo sapiens_hsa002321.60946070
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60881800
36Oxidative phosphorylation_Homo sapiens_hsa001901.59906949
37Protein export_Homo sapiens_hsa030601.57514684
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54429620
39Cocaine addiction_Homo sapiens_hsa050301.48853982
40Taste transduction_Homo sapiens_hsa047421.47316786
41Arachidonic acid metabolism_Homo sapiens_hsa005901.43512897
42Cardiac muscle contraction_Homo sapiens_hsa042601.41154558
43Parkinsons disease_Homo sapiens_hsa050121.40679177
44ABC transporters_Homo sapiens_hsa020101.40558793
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.37739382
46Morphine addiction_Homo sapiens_hsa050321.32985289
47Histidine metabolism_Homo sapiens_hsa003401.29927798
48Herpes simplex infection_Homo sapiens_hsa051681.25577252
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20714959
50Antigen processing and presentation_Homo sapiens_hsa046121.20446188
51Thyroid cancer_Homo sapiens_hsa052161.20385024
52Serotonergic synapse_Homo sapiens_hsa047261.19630102
53Systemic lupus erythematosus_Homo sapiens_hsa053221.16949474
54Glutamatergic synapse_Homo sapiens_hsa047241.16398263
55Fat digestion and absorption_Homo sapiens_hsa049751.15398549
56Epstein-Barr virus infection_Homo sapiens_hsa051691.14897334
57Ovarian steroidogenesis_Homo sapiens_hsa049131.13206092
58N-Glycan biosynthesis_Homo sapiens_hsa005101.12279541
59Chemical carcinogenesis_Homo sapiens_hsa052041.12105043
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10852000
61Viral carcinogenesis_Homo sapiens_hsa052031.06464033
62Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06313014
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06237693
64Purine metabolism_Homo sapiens_hsa002301.05012829
65GABAergic synapse_Homo sapiens_hsa047271.01529108
66HTLV-I infection_Homo sapiens_hsa051661.01081954
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99609194
68Circadian entrainment_Homo sapiens_hsa047130.97581963
69Calcium signaling pathway_Homo sapiens_hsa040200.95997073
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92599294
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92433435
72Colorectal cancer_Homo sapiens_hsa052100.91421229
73Amphetamine addiction_Homo sapiens_hsa050310.90971284
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.89791813
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.89442418
76Huntingtons disease_Homo sapiens_hsa050160.89038891
77Vitamin digestion and absorption_Homo sapiens_hsa049770.88679921
78Cholinergic synapse_Homo sapiens_hsa047250.87950397
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86174337
80Alzheimers disease_Homo sapiens_hsa050100.85336804
81Insulin secretion_Homo sapiens_hsa049110.85020396
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84853871
83Primary immunodeficiency_Homo sapiens_hsa053400.84448398
84MicroRNAs in cancer_Homo sapiens_hsa052060.83938727
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83415871
86Chronic myeloid leukemia_Homo sapiens_hsa052200.83392670
87Olfactory transduction_Homo sapiens_hsa047400.82819981
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82433416
89Fatty acid biosynthesis_Homo sapiens_hsa000610.81261885
90Long-term depression_Homo sapiens_hsa047300.79134378
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77685981
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.76837969
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76526095
94Small cell lung cancer_Homo sapiens_hsa052220.75341937
95Notch signaling pathway_Homo sapiens_hsa043300.74938687
96Measles_Homo sapiens_hsa051620.74725248
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.74134843
98Oocyte meiosis_Homo sapiens_hsa041140.73176060
99Folate biosynthesis_Homo sapiens_hsa007900.72561719
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.71339347
101Selenocompound metabolism_Homo sapiens_hsa004500.70957033
102Basal cell carcinoma_Homo sapiens_hsa052170.70532817
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69832640
104Legionellosis_Homo sapiens_hsa051340.69643628
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69615114
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69330962
107Hepatitis B_Homo sapiens_hsa051610.67841763
108Axon guidance_Homo sapiens_hsa043600.67769444
109Apoptosis_Homo sapiens_hsa042100.67596931
110Glycerolipid metabolism_Homo sapiens_hsa005610.67359924
111Dopaminergic synapse_Homo sapiens_hsa047280.67303439
112Acute myeloid leukemia_Homo sapiens_hsa052210.63369165
113Gastric acid secretion_Homo sapiens_hsa049710.61916579
114Bile secretion_Homo sapiens_hsa049760.61910122
115Retinol metabolism_Homo sapiens_hsa008300.61169963
116Peroxisome_Homo sapiens_hsa041460.61072481
117Alcoholism_Homo sapiens_hsa050340.60666010
118Hippo signaling pathway_Homo sapiens_hsa043900.59009671
119Mineral absorption_Homo sapiens_hsa049780.58437992
120Shigellosis_Homo sapiens_hsa051310.57666274
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55307902
122Leishmaniasis_Homo sapiens_hsa051400.53255144
123Adherens junction_Homo sapiens_hsa045200.52981047
124TGF-beta signaling pathway_Homo sapiens_hsa043500.52754190
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52466486
126Influenza A_Homo sapiens_hsa051640.51024897
127Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50864852
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50828779
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.50364603
130cAMP signaling pathway_Homo sapiens_hsa040240.48884032
131Endometrial cancer_Homo sapiens_hsa052130.47262197
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46402608
133Pathways in cancer_Homo sapiens_hsa052000.46225508
134Hematopoietic cell lineage_Homo sapiens_hsa046400.45792613
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45377086
136B cell receptor signaling pathway_Homo sapiens_hsa046620.45140793
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45079406
138Bladder cancer_Homo sapiens_hsa052190.44990648
139Pancreatic cancer_Homo sapiens_hsa052120.44903868
140Non-small cell lung cancer_Homo sapiens_hsa052230.43282819
141Tyrosine metabolism_Homo sapiens_hsa003500.42893769
142Prolactin signaling pathway_Homo sapiens_hsa049170.41689511
143Steroid biosynthesis_Homo sapiens_hsa001000.41089410
144Prostate cancer_Homo sapiens_hsa052150.40849262
145MAPK signaling pathway_Homo sapiens_hsa040100.39754159
146Hedgehog signaling pathway_Homo sapiens_hsa043400.39715980
147Intestinal immune network for IgA production_Homo sapiens_hsa046720.39398539
148Wnt signaling pathway_Homo sapiens_hsa043100.39369006
149Toxoplasmosis_Homo sapiens_hsa051450.39237663
150T cell receptor signaling pathway_Homo sapiens_hsa046600.38969314
151Drug metabolism - other enzymes_Homo sapiens_hsa009830.38751640
152Other glycan degradation_Homo sapiens_hsa005110.38554158
153Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38476195
154beta-Alanine metabolism_Homo sapiens_hsa004100.38161555
155Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37828974
156Glycosaminoglycan degradation_Homo sapiens_hsa005310.37727400
157Oxytocin signaling pathway_Homo sapiens_hsa049210.36397816
158Galactose metabolism_Homo sapiens_hsa000520.35779341
159Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35585279
160Leukocyte transendothelial migration_Homo sapiens_hsa046700.35196900
161Ras signaling pathway_Homo sapiens_hsa040140.35065940
162Estrogen signaling pathway_Homo sapiens_hsa049150.33712508
163Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32634230
164FoxO signaling pathway_Homo sapiens_hsa040680.32533047
165Salivary secretion_Homo sapiens_hsa049700.32120435
166Viral myocarditis_Homo sapiens_hsa054160.31580782
167Metabolic pathways_Homo sapiens_hsa011000.30421519
168Neurotrophin signaling pathway_Homo sapiens_hsa047220.29161247
169Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28550989
170Sulfur relay system_Homo sapiens_hsa041220.28062484
171TNF signaling pathway_Homo sapiens_hsa046680.27902406
172Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27893351
173mTOR signaling pathway_Homo sapiens_hsa041500.27891312
174Central carbon metabolism in cancer_Homo sapiens_hsa052300.27113328
175Dorso-ventral axis formation_Homo sapiens_hsa043200.26626868
176Cyanoamino acid metabolism_Homo sapiens_hsa004600.26166088
177Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26066380
178Melanogenesis_Homo sapiens_hsa049160.24550295
179Propanoate metabolism_Homo sapiens_hsa006400.22485482
180PPAR signaling pathway_Homo sapiens_hsa033200.21262889
181Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20894958

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