ARL9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ARL9 is a member of the small GTPase protein family with a high degree of similarity to ARF (MIM 103180) proteins of the RAS superfamily. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.97715477
2epithelial cilium movement (GO:0003351)9.81494373
3axonemal dynein complex assembly (GO:0070286)9.54361701
4cilium or flagellum-dependent cell motility (GO:0001539)9.49312402
5reproduction (GO:0000003)9.38921573
6motile cilium assembly (GO:0044458)8.53014758
7regulation of cilium movement (GO:0003352)8.18581128
8cilium movement (GO:0003341)7.76340344
9single fertilization (GO:0007338)7.49487377
10negative regulation of inclusion body assembly (GO:0090084)7.25399983
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.97614776
12sperm capacitation (GO:0048240)6.91343667
13synaptonemal complex organization (GO:0070193)6.77719912
14microtubule depolymerization (GO:0007019)6.59780432
15spermatogenesis (GO:0007283)6.58694412
16synaptonemal complex assembly (GO:0007130)6.57506858
17male gamete generation (GO:0048232)6.55975888
18male meiosis (GO:0007140)6.50741721
19piRNA metabolic process (GO:0034587)6.30265581
20fertilization (GO:0009566)6.28942243
21organic cation transport (GO:0015695)6.19808326
22gamete generation (GO:0007276)6.00397799
23regulation of inclusion body assembly (GO:0090083)5.95364421
24male meiosis I (GO:0007141)5.92029622
25glycerol ether metabolic process (GO:0006662)5.55813354
26chromosome condensation (GO:0030261)5.43021109
27spermatid nucleus differentiation (GO:0007289)5.42405969
28germ cell development (GO:0007281)5.41845548
29calcium ion-dependent exocytosis (GO:0017156)5.36065876
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.28531647
31chromosome organization involved in meiosis (GO:0070192)5.16413318
32ether metabolic process (GO:0018904)5.11150131
33ventricular system development (GO:0021591)5.07888242
34DNA packaging (GO:0006323)5.07477777
35meiosis I (GO:0007127)4.95443881
36base-excision repair, AP site formation (GO:0006285)4.88323032
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.78236479
38multicellular organismal reproductive process (GO:0048609)4.76287188
39regulation of microtubule-based movement (GO:0060632)4.73365316
40cell recognition (GO:0008037)4.68898156
41seminiferous tubule development (GO:0072520)4.45822995
42meiotic nuclear division (GO:0007126)4.45652646
43sexual reproduction (GO:0019953)4.45313421
44single strand break repair (GO:0000012)4.37388173
45chaperone-mediated protein complex assembly (GO:0051131)4.32149552
46protein complex biogenesis (GO:0070271)4.24912507
47monoubiquitinated protein deubiquitination (GO:0035520)4.20728362
48behavioral response to ethanol (GO:0048149)4.18703157
49pyrimidine nucleobase catabolic process (GO:0006208)4.18690707
50mitochondrial respiratory chain complex assembly (GO:0033108)4.16174983
51behavioral response to nicotine (GO:0035095)4.12203357
52genitalia morphogenesis (GO:0035112)4.06374681
53DNA methylation involved in gamete generation (GO:0043046)4.06357779
54left/right pattern formation (GO:0060972)4.05297124
55synapsis (GO:0007129)3.87915039
56pyrimidine nucleotide catabolic process (GO:0006244)3.80767653
57mitotic sister chromatid cohesion (GO:0007064)3.75397651
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.74909455
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.74909455
60NADH dehydrogenase complex assembly (GO:0010257)3.74909455
61multicellular organismal development (GO:0007275)3.74807572
62microtubule severing (GO:0051013)3.72844675
63negative regulation of cytosolic calcium ion concentration (GO:0051481)3.55572504
64indolalkylamine metabolic process (GO:0006586)3.55147100
65response to pheromone (GO:0019236)3.54354039
66cytochrome complex assembly (GO:0017004)3.54154687
67nucleobase catabolic process (GO:0046113)3.53598420
68protein refolding (GO:0042026)3.47566817
69nucleus organization (GO:0006997)3.38449167
70nucleoside diphosphate phosphorylation (GO:0006165)3.35485851
71presynaptic membrane assembly (GO:0097105)3.31058978
72microtubule polymerization or depolymerization (GO:0031109)3.31028171
73DNA deamination (GO:0045006)3.27045423
74glycolytic process (GO:0006096)3.26383454
75GTP biosynthetic process (GO:0006183)3.26159531
76intraciliary transport (GO:0042073)3.25329193
77protein K11-linked deubiquitination (GO:0035871)3.23787918
78ribosomal small subunit assembly (GO:0000028)3.21471217
79regulation of spindle checkpoint (GO:0090231)3.20558519
80parturition (GO:0007567)3.19204193
81meiotic cell cycle (GO:0051321)3.15516571
82transmission of nerve impulse (GO:0019226)3.15229403
83respiratory chain complex IV assembly (GO:0008535)3.14917793
84axoneme assembly (GO:0035082)3.14913693
85photoreceptor cell maintenance (GO:0045494)3.10919215
86meiotic cell cycle process (GO:1903046)3.03939329
87polyamine biosynthetic process (GO:0006596)3.03591665
88regulation of action potential (GO:0098900)3.03405782
89somite development (GO:0061053)3.01859307
90UTP biosynthetic process (GO:0006228)3.01034684
91protein polyglutamylation (GO:0018095)2.98342882
92positive regulation of action potential (GO:0045760)2.95809201
93nonmotile primary cilium assembly (GO:0035058)2.92878872
94alditol metabolic process (GO:0019400)2.92855107
95regulation of protein kinase A signaling (GO:0010738)2.91763109
96short-term memory (GO:0007614)2.89547700
97tryptophan metabolic process (GO:0006568)2.85065504
98C4-dicarboxylate transport (GO:0015740)2.84730547
99retinal cone cell development (GO:0046549)2.84433031
100sequestering of actin monomers (GO:0042989)2.82710311
101serotonin metabolic process (GO:0042428)2.81280820
102indole-containing compound metabolic process (GO:0042430)2.80670099
103positive regulation of macrophage activation (GO:0043032)2.79304876
104cellular ketone body metabolic process (GO:0046950)2.79223352
105cornea development in camera-type eye (GO:0061303)2.79113159
106neuron fate determination (GO:0048664)2.77086881
107protein localization to cilium (GO:0061512)2.76909646
108presynaptic membrane organization (GO:0097090)2.76487382
109nephron tubule morphogenesis (GO:0072078)2.76089721
110nephron epithelium morphogenesis (GO:0072088)2.76089721
111carnitine transport (GO:0015879)2.74904660
112amino-acid betaine transport (GO:0015838)2.74904660
113replication fork processing (GO:0031297)2.74788094
114glycosphingolipid biosynthetic process (GO:0006688)2.72854564
115UTP metabolic process (GO:0046051)2.72624881
116pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.70794182
117detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67708278
118G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66347713
119cilium assembly (GO:0042384)2.65768268
120water-soluble vitamin biosynthetic process (GO:0042364)2.65727135
121polyol catabolic process (GO:0046174)2.65110242
122sister chromatid cohesion (GO:0007062)2.63826492
123auditory receptor cell differentiation (GO:0042491)2.63361565
124brain morphogenesis (GO:0048854)2.62804224
125synaptic transmission, glutamatergic (GO:0035249)2.62697973
126aggressive behavior (GO:0002118)2.61918253
127inositol phosphate catabolic process (GO:0071545)2.61638438
128mechanosensory behavior (GO:0007638)2.59628522
129chromatin silencing (GO:0006342)2.59374638
130response to nitrosative stress (GO:0051409)2.58302041
131microtubule-based movement (GO:0007018)2.57383611
132membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.56662875
133platelet dense granule organization (GO:0060155)2.55897337
134carnitine transmembrane transport (GO:1902603)2.55420096
135deoxyribonucleotide catabolic process (GO:0009264)2.55106363
136primary amino compound metabolic process (GO:1901160)2.55084418
137glutamate receptor signaling pathway (GO:0007215)2.54847085
138gamma-aminobutyric acid signaling pathway (GO:0007214)2.54790673
139retinal ganglion cell axon guidance (GO:0031290)2.53551591
140resolution of meiotic recombination intermediates (GO:0000712)2.53496562
141auditory behavior (GO:0031223)2.52155451
142olfactory bulb development (GO:0021772)2.51911893
143cerebral cortex radially oriented cell migration (GO:0021799)2.51890102
144phosphorylated carbohydrate dephosphorylation (GO:0046838)2.51878277
145inositol phosphate dephosphorylation (GO:0046855)2.51878277
146peptidyl-threonine dephosphorylation (GO:0035970)2.51825456
147positive regulation of oligodendrocyte differentiation (GO:0048714)2.51604866
148protein localization to chromosome, centromeric region (GO:0071459)2.51498035
149detection of light stimulus involved in visual perception (GO:0050908)2.51168403
150detection of light stimulus involved in sensory perception (GO:0050962)2.51168403
151photoreceptor cell development (GO:0042461)2.50971566
152regulation of feeding behavior (GO:0060259)2.50393626
153kynurenine metabolic process (GO:0070189)2.49561058
154energy coupled proton transport, down electrochemical gradient (GO:0015985)2.49235344
155ATP synthesis coupled proton transport (GO:0015986)2.49235344
156ketone body metabolic process (GO:1902224)2.49187222
157lactate metabolic process (GO:0006089)2.48987247
158cellular response to arsenic-containing substance (GO:0071243)2.48700703
159dendritic spine morphogenesis (GO:0060997)2.48698706
160cilium organization (GO:0044782)2.47716975
161nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.47350588
162cell redox homeostasis (GO:0045454)2.47303132
163peptidyl-histidine modification (GO:0018202)2.46383521
164neuron-neuron synaptic transmission (GO:0007270)2.45611945
165histone exchange (GO:0043486)2.45467619
166limb development (GO:0060173)2.45228482
167appendage development (GO:0048736)2.45228482
168mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43950826
169guanosine-containing compound biosynthetic process (GO:1901070)2.43371871
170RNA destabilization (GO:0050779)2.43365053
171negative regulation of systemic arterial blood pressure (GO:0003085)2.42730565
172exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.42280498
173nucleosome disassembly (GO:0006337)2.41689324
174protein-DNA complex disassembly (GO:0032986)2.41689324
175regulation of protein kinase C signaling (GO:0090036)2.40671998
176sperm motility (GO:0030317)14.3260574
177fusion of sperm to egg plasma membrane (GO:0007342)13.3539898
178acrosome reaction (GO:0007340)12.1452713
179cell wall macromolecule metabolic process (GO:0044036)11.7912930
180cell wall macromolecule catabolic process (GO:0016998)11.7912930
181sperm-egg recognition (GO:0035036)11.1847674
182multicellular organism reproduction (GO:0032504)10.7995247
183acrosome assembly (GO:0001675)10.6982816
184binding of sperm to zona pellucida (GO:0007339)10.2033932
185plasma membrane fusion (GO:0045026)10.1691067
186cell-cell recognition (GO:0009988)10.0039828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.07801746
2EZH2_22144423_ChIP-Seq_EOC_Human3.91256059
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.28415817
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.67052753
5CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.60270970
6GBX2_23144817_ChIP-Seq_PC3_Human2.56452997
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50956970
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.42441444
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35507809
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33101757
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23347718
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22620146
13VDR_22108803_ChIP-Seq_LS180_Human2.18100154
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13857875
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12938641
16IGF1R_20145208_ChIP-Seq_DFB_Human2.11829333
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.10811210
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.08228103
19P300_19829295_ChIP-Seq_ESCs_Human2.06470422
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01033183
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2882700
22TAF15_26573619_Chip-Seq_HEK293_Human1.98540597
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95475116
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.95380540
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.87753223
26EWS_26573619_Chip-Seq_HEK293_Human1.83703832
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.82529253
28FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81672747
29TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.77557758
30SOX2_22085726_ChIP-Seq_NPCs_Mouse1.77097442
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76881447
32STAT1_17558387_ChIP-Seq_HELA_Human1.76700055
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74360025
34RNF2_27304074_Chip-Seq_NSC_Mouse1.70714401
35ZNF274_21170338_ChIP-Seq_K562_Hela1.70506147
36KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70491417
37GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.70446031
38ELK4_26923725_Chip-Seq_MESODERM_Mouse1.65381419
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63588615
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63157037
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62764365
42* SMAD4_21799915_ChIP-Seq_A2780_Human1.60400952
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.59856956
44MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59663289
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58312627
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56953375
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52977716
48TP53_22573176_ChIP-Seq_HFKS_Human1.52713122
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51075772
50GATA3_21867929_ChIP-Seq_CD8_Mouse1.50806282
51WDR5_24793694_ChIP-Seq_LNCAP_Human1.50700452
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49066310
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48968793
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.48858052
55MYC_18940864_ChIP-ChIP_HL60_Human1.48678772
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48259976
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.47171156
58LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.46770722
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46439249
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45764242
61KDM2B_26808549_Chip-Seq_REH_Human1.45535679
62CBP_20019798_ChIP-Seq_JUKART_Human1.45266209
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45266209
64STAT3_23295773_ChIP-Seq_U87_Human1.45225568
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44843315
66FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.43769122
67ER_23166858_ChIP-Seq_MCF-7_Human1.42277389
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40652495
69TCF4_22108803_ChIP-Seq_LS180_Human1.36986238
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36873729
71* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36110292
72TCF4_23295773_ChIP-Seq_U87_Human1.35442080
73IRF1_19129219_ChIP-ChIP_H3396_Human1.35285407
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34798767
75ERG_20517297_ChIP-Seq_VCAP_Human1.34516082
76P53_21459846_ChIP-Seq_SAOS-2_Human1.32347175
77ELK1_19687146_ChIP-ChIP_HELA_Human1.31977534
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31757866
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31362039
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31289615
81CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31213687
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.31164817
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.30970666
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30347436
85NANOG_19829295_ChIP-Seq_ESCs_Human1.29704050
86SOX2_19829295_ChIP-Seq_ESCs_Human1.29704050
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27584651
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.26894610
89GATA3_21867929_ChIP-Seq_TH1_Mouse1.25745675
90AR_25329375_ChIP-Seq_VCAP_Human1.25109064
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24587069
92BCAT_22108803_ChIP-Seq_LS180_Human1.24456787
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.24197018
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23411086
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23348280
96CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23088461
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22769887
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22406816
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22260033
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22195704
101FUS_26573619_Chip-Seq_HEK293_Human1.21435750
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21068244
103* RUNX2_22187159_ChIP-Seq_PCA_Human1.20033094
104GF1_26923725_Chip-Seq_HPCs_Mouse1.19871021
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.19616288
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19207902
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19207902
108SPI1_26923725_Chip-Seq_HPCs_Mouse1.18539209
109JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17946062
110NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17906584
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16708629
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.16128344
113PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15925117
114EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.15372070
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15101974
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14606664
117SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14338385
118* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13966699
119POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13219275
120FOXM1_23109430_ChIP-Seq_U2OS_Human1.13047853
121* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12701348
122PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12428807
123RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11979038
124AR_21572438_ChIP-Seq_LNCaP_Human1.11096822
125EZH2_27294783_Chip-Seq_ESCs_Mouse1.10564227
126SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10520810
127ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10339469
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10125574
129MYC_27129775_Chip-Seq_CORNEA_Mouse1.09942244
130TP63_19390658_ChIP-ChIP_HaCaT_Human1.09377823
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09270999
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09042636
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07142345
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06439175
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.06342794
136FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04898785
137FOXA1_25329375_ChIP-Seq_VCAP_Human1.04898785
138CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04432334
139KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04374256
140EZH2_27294783_Chip-Seq_NPCs_Mouse1.03889609
141FLI1_21867929_ChIP-Seq_CD8_Mouse1.03820988
142EED_16625203_ChIP-ChIP_MESCs_Mouse1.03025156
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02927321
144SOX11_22085726_ChIP-Seq_ESNs_Mouse1.02598412
145TET1_21451524_ChIP-Seq_MESCs_Mouse1.02265192
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02255285
147P53_22387025_ChIP-Seq_ESCs_Mouse1.02060032
148RARA_24833708_ChIP-Seq_LIVER_Mouse1.01509831
149GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01114442
150GATA3_21878914_ChIP-Seq_MCF-7_Human1.00556769
151E2F1_18555785_Chip-Seq_ESCs_Mouse0.99900065
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99852597
153RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98827566
154ESET_19884257_ChIP-Seq_ESCs_Mouse0.98546573
155SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98297592
156PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98166860
157JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97579710
158CRX_20693478_ChIP-Seq_RETINA_Mouse0.97428004
159CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96580107
160HOXB7_26014856_ChIP-Seq_BT474_Human0.96413235
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.96382313
162REST_21632747_ChIP-Seq_MESCs_Mouse0.93151428
163GF1B_26923725_Chip-Seq_HPCs_Mouse0.92224385
164PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90035530
165LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88309417
166NANOG_20526341_ChIP-Seq_ESCs_Human0.88125772
167STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87045365
168RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86273601
169SMAD4_21741376_ChIP-Seq_EPCs_Human0.86065178
170CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85326987
171SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84314683
172YY1_22570637_ChIP-Seq_MALME-3M_Human0.84271234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.78860411
2MP0001929_abnormal_gametogenesis5.35432573
3MP0008877_abnormal_DNA_methylation3.70786679
4MP0003880_abnormal_central_pattern3.37956005
5MP0002210_abnormal_sex_determination3.36344484
6MP0002161_abnormal_fertility/fecundity3.21184152
7MP0001145_abnormal_male_reproductive2.84931219
8MP0006292_abnormal_olfactory_placode2.61043356
9MP0005670_abnormal_white_adipose2.54501550
10MP0004147_increased_porphyrin_level2.53607456
11MP0006072_abnormal_retinal_apoptosis2.50319246
12MP0003123_paternal_imprinting2.47009273
13MP0010386_abnormal_urinary_bladder2.45586922
14MP0000653_abnormal_sex_gland2.45029683
15MP0005646_abnormal_pituitary_gland2.42208752
16MP0002837_dystrophic_cardiac_calcinosis2.24482130
17MP0005551_abnormal_eye_electrophysiolog2.18191349
18MP0003787_abnormal_imprinting2.04103723
19MP0005410_abnormal_fertilization15.8114134
20MP0004859_abnormal_synaptic_plasticity1.99554257
21MP0006276_abnormal_autonomic_nervous1.93614426
22MP0002282_abnormal_trachea_morphology1.92886194
23MP0001529_abnormal_vocalization1.92290776
24MP0009745_abnormal_behavioral_response1.88352410
25MP0008789_abnormal_olfactory_epithelium1.86566600
26MP0001984_abnormal_olfaction1.82757177
27MP0002272_abnormal_nervous_system1.79969237
28MP0002160_abnormal_reproductive_system1.75462451
29MP0004885_abnormal_endolymph1.74712968
30MP0003635_abnormal_synaptic_transmissio1.67744538
31MP0003011_delayed_dark_adaptation1.65624475
32MP0004142_abnormal_muscle_tone1.64979921
33MP0002102_abnormal_ear_morphology1.56194165
34MP0002234_abnormal_pharynx_morphology1.53194540
35MP0002557_abnormal_social/conspecific_i1.52363297
36MP0002735_abnormal_chemical_nociception1.50652436
37MP0000778_abnormal_nervous_system1.47861425
38MP0004133_heterotaxia1.45812752
39MP0001485_abnormal_pinna_reflex1.45382700
40MP0003122_maternal_imprinting1.41215253
41MP0002638_abnormal_pupillary_reflex1.40733029
42MP0005253_abnormal_eye_physiology1.39024929
43MP0008872_abnormal_physiological_respon1.38880901
44MP0004742_abnormal_vestibular_system1.38532102
45MP0005623_abnormal_meninges_morphology1.37103914
46MP0001486_abnormal_startle_reflex1.37026790
47MP0003646_muscle_fatigue1.36980296
48MP0000372_irregular_coat_pigmentation1.35966349
49MP0002653_abnormal_ependyma_morphology1.35714572
50MP0002064_seizures1.35259080
51MP0002733_abnormal_thermal_nociception1.35087474
52MP0002063_abnormal_learning/memory/cond1.34485779
53MP0000569_abnormal_digit_pigmentation1.34388137
54MP0005084_abnormal_gallbladder_morpholo1.32250706
55MP0002572_abnormal_emotion/affect_behav1.32234113
56MP0001970_abnormal_pain_threshold1.31713938
57MP0000516_abnormal_urinary_system1.30298687
58MP0005367_renal/urinary_system_phenotyp1.30298687
59MP0003890_abnormal_embryonic-extraembry1.29059808
60MP0005499_abnormal_olfactory_system1.26619339
61MP0005394_taste/olfaction_phenotype1.26619339
62MP0001765_abnormal_ion_homeostasis1.26210766
63MP0003718_maternal_effect1.22432733
64MP0002067_abnormal_sensory_capabilities1.20614019
65MP0002095_abnormal_skin_pigmentation1.20377159
66MP0004924_abnormal_behavior1.18990786
67MP0005386_behavior/neurological_phenoty1.18990786
68MP0002938_white_spotting1.18415153
69MP0002822_catalepsy1.16948354
70MP0009379_abnormal_foot_pigmentation1.14763492
71MP0000631_abnormal_neuroendocrine_gland1.12581580
72MP0002184_abnormal_innervation1.12462992
73MP0005423_abnormal_somatic_nervous1.11297217
74MP0005389_reproductive_system_phenotype1.10752831
75MP0001501_abnormal_sleep_pattern1.09423420
76MP0005195_abnormal_posterior_eye1.08483345
77MP0004270_analgesia1.07482099
78MP0000427_abnormal_hair_cycle1.07197112
79MP0004233_abnormal_muscle_weight1.06066686
80MP0000049_abnormal_middle_ear1.05200974
81MP0001905_abnormal_dopamine_level1.04690501
82MP0002752_abnormal_somatic_nervous1.03197920
83MP0008058_abnormal_DNA_repair1.01276928
84MP0002233_abnormal_nose_morphology1.00499982
85MP0000538_abnormal_urinary_bladder0.98641154
86MP0001986_abnormal_taste_sensitivity0.98457945
87MP0003111_abnormal_nucleus_morphology0.97315771
88MP0002734_abnormal_mechanical_nocicepti0.95904769
89MP0005174_abnormal_tail_pigmentation0.95260583
90MP0001440_abnormal_grooming_behavior0.92777473
91MP0002882_abnormal_neuron_morphology0.92669434
92MP0003119_abnormal_digestive_system0.91943084
93MP0002736_abnormal_nociception_after0.90793507
94MP0003115_abnormal_respiratory_system0.90788273
95MP0003121_genomic_imprinting0.90086724
96MP0002229_neurodegeneration0.88908579
97MP0000383_abnormal_hair_follicle0.87152523
98MP0002751_abnormal_autonomic_nervous0.86352400
99MP0000955_abnormal_spinal_cord0.85774662
100MP0003937_abnormal_limbs/digits/tail_de0.84381594
101MP0005636_abnormal_mineral_homeostasis0.83992980
102MP0002163_abnormal_gland_morphology0.83555293
103MP0008995_early_reproductive_senescence0.82375806
104MP0005645_abnormal_hypothalamus_physiol0.81249105
105MP0003195_calcinosis0.79669222
106MP0004043_abnormal_pH_regulation0.78839526
107MP0009697_abnormal_copulation0.77747567
108MP0006054_spinal_hemorrhage0.75856994
109MP0010094_abnormal_chromosome_stability0.74169637
110MP0001764_abnormal_homeostasis0.71272304
111MP0005397_hematopoietic_system_phenotyp0.69036440
112MP0001545_abnormal_hematopoietic_system0.69036440
113MP0000534_abnormal_ureter_morphology0.66821313
114MP0002139_abnormal_hepatobiliary_system0.66647437
115MP0005647_abnormal_sex_gland0.65457533
116MP0003942_abnormal_urinary_system0.63657837
117MP0003699_abnormal_female_reproductive0.58307478
118MP0003878_abnormal_ear_physiology0.58084005
119MP0005377_hearing/vestibular/ear_phenot0.58084005
120MP0001119_abnormal_female_reproductive0.52785731
121MP0001968_abnormal_touch/_nociception0.52434891
122MP0004197_abnormal_fetal_growth/weight/0.51967379
123MP0003786_premature_aging0.50761853
124MP0004808_abnormal_hematopoietic_stem0.50079781
125MP0000358_abnormal_cell_content/0.48807214
126MP0003329_amyloid_beta_deposits0.48584969
127MP0008007_abnormal_cellular_replicative0.46398639
128MP0003950_abnormal_plasma_membrane0.45075310
129MP0003943_abnormal_hepatobiliary_system0.43548670
130MP0003315_abnormal_perineum_morphology0.42411771
131MP0005666_abnormal_adipose_tissue0.42135461
132MP0001730_embryonic_growth_arrest0.41973949
133MP0003077_abnormal_cell_cycle0.41664369
134MP0005360_urolithiasis0.41449158
135MP0001293_anophthalmia0.39896808
136MP0003656_abnormal_erythrocyte_physiolo0.39507741
137MP0001270_distended_abdomen0.37921113
138MP0005365_abnormal_bile_salt0.35724739
139MP0002928_abnormal_bile_duct0.34836176
140MP0009672_abnormal_birth_weight0.33241245
141MP0004134_abnormal_chest_morphology0.31290149
142MP0001849_ear_inflammation0.30865383
143MP0000604_amyloidosis0.29134829
144MP0001697_abnormal_embryo_size0.29117199
145MP0000639_abnormal_adrenal_gland0.28884142
146MP0009278_abnormal_bone_marrow0.28549505
147MP0006036_abnormal_mitochondrial_physio0.28341142
148MP0005380_embryogenesis_phenotype0.28335289
149MP0001672_abnormal_embryogenesis/_devel0.28335289
150MP0001919_abnormal_reproductive_system0.28266329
151MP0003385_abnormal_body_wall0.28001553
152MP0002109_abnormal_limb_morphology0.27731228
153MP0003879_abnormal_hair_cell0.27624315
154MP0004036_abnormal_muscle_relaxation0.26847305
155MP0009046_muscle_twitch0.26523927
156MP0003984_embryonic_growth_retardation0.26192031
157MP0002115_abnormal_skeleton_extremities0.26033850
158MP0009250_abnormal_appendicular_skeleto0.25238846
159MP0002080_prenatal_lethality0.25077565
160MP0005379_endocrine/exocrine_gland_phen0.24332525
161MP0002909_abnormal_adrenal_gland0.24120212
162MP0003868_abnormal_feces_composition0.23529856
163MP0006138_congestive_heart_failure0.23507891
164MP0005503_abnormal_tendon_morphology0.23403289
165MP0002084_abnormal_developmental_patter0.23160845
166MP0002088_abnormal_embryonic_growth/wei0.23013359
167MP0008057_abnormal_DNA_replication0.22966822
168MP0010307_abnormal_tumor_latency0.22206932
169MP0001177_atelectasis0.22190120
170MP0002269_muscular_atrophy0.22035196
171MP0005319_abnormal_enzyme/_coenzyme0.21880402
172MP0001324_abnormal_eye_pigmentation0.21618902
173MP0003279_aneurysm0.21604298
174MP0000733_abnormal_muscle_development0.21508885
175MP0003693_abnormal_embryo_hatching0.21241581
176MP0009115_abnormal_fat_cell0.20964773
177MP0006035_abnormal_mitochondrial_morpho0.20132763
178MP0008875_abnormal_xenobiotic_pharmacok0.19181657

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)8.95891752
2Abnormal respiratory epithelium morphology (HP:0012253)8.95891752
3Abnormal respiratory motile cilium physiology (HP:0012261)8.65917113
4Abnormal ciliary motility (HP:0012262)6.95754439
5Infertility (HP:0000789)6.92443046
6Rhinitis (HP:0012384)6.82334555
7Chronic bronchitis (HP:0004469)6.45154274
8Nasal polyposis (HP:0100582)5.90206935
9Male infertility (HP:0003251)5.07094974
10Abnormality of the nasal mucosa (HP:0000433)4.89486747
11Focal motor seizures (HP:0011153)4.67084265
12Bronchitis (HP:0012387)4.12137338
13Abnormal spermatogenesis (HP:0008669)4.03591474
14Bronchiectasis (HP:0002110)3.94219699
15Nephronophthisis (HP:0000090)3.92369322
16Pancreatic cysts (HP:0001737)3.81514751
17Pancreatic fibrosis (HP:0100732)3.67542853
18Recurrent sinusitis (HP:0011108)3.54998599
19Atonic seizures (HP:0010819)3.48735262
20True hermaphroditism (HP:0010459)3.37607615
21Focal seizures (HP:0007359)3.36125522
22Recurrent otitis media (HP:0000403)3.29720807
23Volvulus (HP:0002580)3.23794028
24Gait imbalance (HP:0002141)3.01663124
25Congenital primary aphakia (HP:0007707)2.95338541
26Congenital stationary night blindness (HP:0007642)2.94797397
27Abnormality of the renal medulla (HP:0100957)2.87213125
28Absence seizures (HP:0002121)2.84521427
29Tubulointerstitial nephritis (HP:0001970)2.83569087
30Aplasia/Hypoplasia of the spleen (HP:0010451)2.83144082
31Abnormal rod and cone electroretinograms (HP:0008323)2.82651253
32Nephrogenic diabetes insipidus (HP:0009806)2.81218117
33Dialeptic seizures (HP:0011146)2.77767742
34Asplenia (HP:0001746)2.71766672
35Epiphyseal dysplasia (HP:0002656)2.69842944
36Impulsivity (HP:0100710)2.64967444
37Broad-based gait (HP:0002136)2.60967577
38Attenuation of retinal blood vessels (HP:0007843)2.58774308
39Recurrent bronchitis (HP:0002837)2.56792713
40Febrile seizures (HP:0002373)2.56277979
41Tubular atrophy (HP:0000092)2.54126151
42Pendular nystagmus (HP:0012043)2.52815481
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51466892
44Gaze-evoked nystagmus (HP:0000640)2.50368441
45Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.48959017
46Absent epiphyses (HP:0010577)2.48959017
47Gonadotropin excess (HP:0000837)2.43879419
48Abolished electroretinogram (ERG) (HP:0000550)2.43572924
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.43480401
50Irregular epiphyses (HP:0010582)2.39933157
51Acute necrotizing encephalopathy (HP:0006965)2.38915962
52Chronic hepatic failure (HP:0100626)2.38323094
533-Methylglutaconic aciduria (HP:0003535)2.34378709
54Dysdiadochokinesis (HP:0002075)2.34041831
55Fibular hypoplasia (HP:0003038)2.33913221
56Increased corneal curvature (HP:0100692)2.33738515
57Keratoconus (HP:0000563)2.33738515
58Hypoplasia of the capital femoral epiphysis (HP:0003090)2.33162539
59Myokymia (HP:0002411)2.30273813
60Molar tooth sign on MRI (HP:0002419)2.29528696
61Abnormality of midbrain morphology (HP:0002418)2.29528696
62Genital tract atresia (HP:0001827)2.28585845
63Short tibia (HP:0005736)2.27939081
64Progressive macrocephaly (HP:0004481)2.26932947
65Azoospermia (HP:0000027)2.25929661
66Mitochondrial inheritance (HP:0001427)2.24934769
67Small epiphyses (HP:0010585)2.24657009
68Generalized tonic-clonic seizures (HP:0002069)2.22944176
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.22295950
70Tubulointerstitial abnormality (HP:0001969)2.21783991
71Abnormal gallbladder physiology (HP:0012438)2.20111894
72Cholecystitis (HP:0001082)2.20111894
73Vaginal atresia (HP:0000148)2.20074233
74Hepatocellular necrosis (HP:0001404)2.18399729
75Hypochromic microcytic anemia (HP:0004840)2.18342163
76Median cleft lip (HP:0000161)2.12549053
77Hypothermia (HP:0002045)2.12096326
78Flattened epiphyses (HP:0003071)2.11599623
79Acute encephalopathy (HP:0006846)2.10745495
80Abnormal mitochondria in muscle tissue (HP:0008316)2.08400598
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.04479820
82Degeneration of the lateral corticospinal tracts (HP:0002314)2.04479820
83Increased hepatocellular lipid droplets (HP:0006565)2.04093700
84Increased CSF lactate (HP:0002490)2.03647628
85Intestinal atresia (HP:0011100)2.03194690
86Thyroid-stimulating hormone excess (HP:0002925)2.01644684
87Optic nerve hypoplasia (HP:0000609)2.01289533
88Dynein arm defect of respiratory motile cilia (HP:0012255)13.1749903
89Absent/shortened dynein arms (HP:0200106)13.1749903
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.7544886
91Poor coordination (HP:0002370)1.99926166
92Renal Fanconi syndrome (HP:0001994)1.99660533
93Type II lissencephaly (HP:0007260)1.99501157
94Postaxial hand polydactyly (HP:0001162)1.99331732
95Absent frontal sinuses (HP:0002688)1.97570594
96Inability to walk (HP:0002540)1.97406824
97Short ribs (HP:0000773)1.97380592
98Bony spicule pigmentary retinopathy (HP:0007737)1.97363339
99Colon cancer (HP:0003003)1.92967634
100Preaxial hand polydactyly (HP:0001177)1.89662209
101Partial agenesis of the corpus callosum (HP:0001338)1.89059263
102Progressive inability to walk (HP:0002505)1.88279785
103Sclerocornea (HP:0000647)1.87547768
104Progressive cerebellar ataxia (HP:0002073)1.87499296
105Urethral obstruction (HP:0000796)1.87493071
106Lipid accumulation in hepatocytes (HP:0006561)1.87388882
107Dyschromatopsia (HP:0007641)1.87344118
108Abnormality of macular pigmentation (HP:0008002)1.82751747
109Short femoral neck (HP:0100864)1.81919077
110Anencephaly (HP:0002323)1.81815950
111Septo-optic dysplasia (HP:0100842)1.80570880
112Severe visual impairment (HP:0001141)1.80276400
113Occipital encephalocele (HP:0002085)1.80259060
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79024916
115Delayed epiphyseal ossification (HP:0002663)1.78953271
116Male pseudohermaphroditism (HP:0000037)1.78718021
117Hyperventilation (HP:0002883)1.78420862
118Asymmetric septal hypertrophy (HP:0001670)1.78208392
119Hepatic necrosis (HP:0002605)1.78100344
120Action tremor (HP:0002345)1.77445291
121Retinitis pigmentosa (HP:0000510)1.76790869
122Abnormal protein N-linked glycosylation (HP:0012347)1.73958316
123Abnormal protein glycosylation (HP:0012346)1.73958316
124Abnormal glycosylation (HP:0012345)1.73958316
125Metaphyseal dysplasia (HP:0100255)1.72000937
126Bell-shaped thorax (HP:0001591)1.70352387
127Spastic tetraparesis (HP:0001285)1.69713969
128Tubulointerstitial fibrosis (HP:0005576)1.65057031
129Broad distal phalanx of finger (HP:0009836)1.64264881
130Abnormality of femoral epiphyses (HP:0006499)1.62755792
131Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.62755792
132Abnormality of the epiphysis of the femoral head (HP:0010574)1.59450521
133Medial flaring of the eyebrow (HP:0010747)1.58059708
134Polydipsia (HP:0001959)1.57633816
135Abnormal drinking behavior (HP:0030082)1.57633816
136Bile duct proliferation (HP:0001408)1.54181497
137Abnormal biliary tract physiology (HP:0012439)1.54181497
138Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.51972009
139Hepatoblastoma (HP:0002884)1.48671260
140Abnormality of the renal cortex (HP:0011035)1.48101018
141Abnormality of renal excretion (HP:0011036)1.47306814
142Decreased central vision (HP:0007663)1.47069982
143Stage 5 chronic kidney disease (HP:0003774)1.47008978
144Rhizomelia (HP:0008905)1.46660378
145Flat capital femoral epiphysis (HP:0003370)1.46534235
146Supernumerary spleens (HP:0009799)1.45884409
147Neurofibrillary tangles (HP:0002185)1.44962463
148Cerebellar dysplasia (HP:0007033)1.44916303
149Heterotopia (HP:0002282)1.44309682
150Short nail (HP:0001799)1.41025338
151Glucose intolerance (HP:0000833)1.40745640
152Postaxial foot polydactyly (HP:0001830)1.40188435
153Easy fatigability (HP:0003388)1.39161398
154Hemorrhage of the eye (HP:0011885)1.39122793
155Oculomotor apraxia (HP:0000657)1.39096912
156Aplasia/Hypoplasia of the fibula (HP:0006492)1.37256695
157Abnormality of the femoral head (HP:0003368)1.36788502
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.36511542
159Metaphyseal cupping (HP:0003021)1.34407342
160Choroideremia (HP:0001139)1.33247265
161Short thorax (HP:0010306)1.32027357
162Cystic liver disease (HP:0006706)1.31034104
163Cupped ribs (HP:0000887)1.30369657
164Neonatal hypoglycemia (HP:0001998)1.29366294
165Abnormality of the vitreous humor (HP:0004327)1.28864078
166Lissencephaly (HP:0001339)1.28086278
167Facial cleft (HP:0002006)1.27845756
168Nephroblastoma (Wilms tumor) (HP:0002667)1.27082834
169Dysmetric saccades (HP:0000641)1.26431597
170Congenital hepatic fibrosis (HP:0002612)1.25481318
171Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.25102367
172Diastasis recti (HP:0001540)1.24982318
173Vitreoretinal degeneration (HP:0000655)1.24662122
174Abnormal tarsal ossification (HP:0008369)1.24294087
175Bundle branch block (HP:0011710)1.22983433
176Cerebral inclusion bodies (HP:0100314)1.22782001
177Abnormal urine output (HP:0012590)1.22741142
178Abnormality of dentin (HP:0010299)1.22480805
179Amyotrophic lateral sclerosis (HP:0007354)1.21329964

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.59265685
2PDK48.59265685
3PDK25.58011023
4TESK15.30783451
5PRKD35.14902077
6FRK4.20064376
7ICK3.96300020
8MAP4K23.36839838
9CASK3.13279195
10ADRBK22.93403555
11TAOK32.74169694
12MARK12.41580911
13ZAK2.18503417
14WNK42.08943827
15EPHA41.99969939
16PTK2B1.96891438
17BCR1.91959869
18STK161.87812719
19PINK11.76517638
20PNCK1.72255512
21MAP2K71.70235272
22GRK11.66691170
23MAPK131.63431490
24WNK31.58986191
25MAP3K41.57896806
26BMPR1B1.55442445
27CAMKK21.55084679
28STK391.45971987
29BCKDK1.43858405
30NEK21.43393546
31ERBB31.40620935
32CSNK1G21.38382598
33DYRK1B1.35824015
34MAP3K121.33209643
35STK381.28509323
36MST41.28189933
37PKN11.27678512
38ADRBK11.25053099
39PAK31.16687845
40EIF2AK31.14869521
41PDK11.13187160
42DYRK21.12863064
43DAPK21.07677910
44OXSR11.06813310
45INSRR1.03720008
46CDC71.03070561
47GRK71.02903506
48CSNK1G31.00486159
49GRK50.99838319
50TXK0.98807931
51NTRK20.98382728
52PRKCE0.96698112
53CSNK1G10.94814349
54PLK20.92727329
55PLK30.91871580
56TIE10.89664432
57CDK120.88708836
58STK30.87576765
59VRK10.87533753
60CDK190.86470293
61BUB10.81985566
62MAP2K60.80309061
63CSNK1A1L0.79696861
64PASK0.73314242
65CAMK10.70448658
66MAP2K40.69813544
67CAMK2A0.68147910
68CDK80.67749329
69SRPK10.67589441
70MINK10.65736018
71KDR0.65471896
72WNK10.65263816
73BRSK20.64770248
74STK38L0.64695304
75PRKACA0.62223616
76MAPK150.62159552
77BRSK10.61902649
78TLK10.58816247
79TEC0.57768108
80STK110.57530303
81NTRK30.57140440
82PHKG20.54775166
83PHKG10.54775166
84EPHB20.53541894
85PDPK10.51693956
86DYRK30.51048211
87PAK40.50832885
88RPS6KA50.50250960
89LATS10.49743722
90MAP2K10.49031844
91SIK20.48662200
92EEF2K0.47997620
93PKN20.47905277
94CHEK20.47313970
95CHEK10.45951687
96WEE10.44570909
97RAF10.44552935
98TSSK60.44448268
99TYRO30.43014565
100CDK50.42996953
101PRKG10.42835862
102TTK0.41631374
103PRKCA0.41304604
104VRK20.41191964
105CAMK1G0.41038882
106PAK10.40713039
107PAK60.40609405
108IRAK10.40357729
109MARK30.38788111
110MAP2K20.38646408
111CSNK1D0.37992966
112EIF2AK10.36298094
113TRIB30.36277000
114CSNK1A10.35962037
115CCNB10.35407125
116PRKACB0.34999256
117PBK0.33649472
118RIPK40.33284708
119CAMK40.32536741
120MAP3K100.32254810
121NUAK10.32137379
122ROCK10.31982610
123AKT30.31518518
124TNIK0.31144012
125LMTK20.30984625
126PAK20.30705684
127CLK10.29954755
128STK100.29230441
129PRKG20.29056314
130MTOR0.28708172
131CAMKK10.26882882
132PLK10.25719143
133PRKCG0.24372623
134TGFBR10.21792526
135PIM10.21621813
136ATM0.21521016
137RPS6KB10.20714048
138PLK40.20253548
139ERN10.18196278
140PRKCZ0.16715243
141BRAF0.16276829
142DDR20.15906077
143MKNK20.14455994
144MAPK40.12667077
145CSNK2A10.12578951
146CDK60.12566226
147PRKAA10.12537125
148MAP3K30.12460483
149MUSK0.10974556
150YES10.09434300
151MKNK10.08825399
152IRAK20.07407641
153CSNK2A20.07277104
154ZAP700.07105754
155PTK60.06956893
156CDK20.06558287
157MAP4K10.06423220
158AURKA0.06294272
159PRKACG0.05450908
160TBK10.04844675
161TAOK10.04785612
162MAPKAPK50.04688959
163GSK3B0.04428598
164MAP3K10.04228442
165ATR0.03749224
166CDK10.03550450
167RPS6KA10.02676189
168NEK60.02607200
169PRKCD0.02248033
170GSK3A0.01983415
171MAPK80.01384930
172MAPK100.00981293
173PRKCB0.00969667
174RPS6KA40.00541165
175TGFBR20.00264273
176AURKB-0.0049519

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.71009599
2Vitamin B6 metabolism_Homo sapiens_hsa007504.43056735
3Fatty acid biosynthesis_Homo sapiens_hsa000614.32160436
4Pyruvate metabolism_Homo sapiens_hsa006203.35305945
5Nicotine addiction_Homo sapiens_hsa050333.34359435
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.92857962
7Oxidative phosphorylation_Homo sapiens_hsa001902.75473493
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.72482570
9Propanoate metabolism_Homo sapiens_hsa006402.70169651
10Taste transduction_Homo sapiens_hsa047422.56302913
11Glucagon signaling pathway_Homo sapiens_hsa049222.55976406
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.51217538
13Phototransduction_Homo sapiens_hsa047442.50673164
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.39415963
15Carbohydrate digestion and absorption_Homo sapiens_hsa049732.37664878
16Selenocompound metabolism_Homo sapiens_hsa004502.35483597
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35323224
18Linoleic acid metabolism_Homo sapiens_hsa005912.33592154
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31008169
20Parkinsons disease_Homo sapiens_hsa050122.20308597
21Nitrogen metabolism_Homo sapiens_hsa009102.10577620
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02615896
23Morphine addiction_Homo sapiens_hsa050321.97188938
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92590805
25Ribosome_Homo sapiens_hsa030101.88748078
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82986648
27Oocyte meiosis_Homo sapiens_hsa041141.81922905
28Fructose and mannose metabolism_Homo sapiens_hsa000511.80606041
29Glycerolipid metabolism_Homo sapiens_hsa005611.79731839
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.79164482
31Basal transcription factors_Homo sapiens_hsa030221.74577393
32Protein export_Homo sapiens_hsa030601.74024741
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71458122
34Butanoate metabolism_Homo sapiens_hsa006501.67327331
35PPAR signaling pathway_Homo sapiens_hsa033201.66654738
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66126562
37RNA polymerase_Homo sapiens_hsa030201.64645271
38GABAergic synapse_Homo sapiens_hsa047271.61593558
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59895823
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.57448959
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.49565771
42Alzheimers disease_Homo sapiens_hsa050101.46581335
43Olfactory transduction_Homo sapiens_hsa047401.46432091
44Dorso-ventral axis formation_Homo sapiens_hsa043201.45826592
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.45826205
46Homologous recombination_Homo sapiens_hsa034401.45604184
47RNA transport_Homo sapiens_hsa030131.42591943
48Glutamatergic synapse_Homo sapiens_hsa047241.42119732
49Pentose phosphate pathway_Homo sapiens_hsa000301.41537392
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.40369163
51Carbon metabolism_Homo sapiens_hsa012001.37992770
52Tryptophan metabolism_Homo sapiens_hsa003801.31332047
53Fatty acid degradation_Homo sapiens_hsa000711.30393082
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.29167380
55Peroxisome_Homo sapiens_hsa041461.29070559
56Fat digestion and absorption_Homo sapiens_hsa049751.28064031
57Mineral absorption_Homo sapiens_hsa049781.28016152
58Protein digestion and absorption_Homo sapiens_hsa049741.26351637
59Maturity onset diabetes of the young_Homo sapiens_hsa049501.25701298
60Purine metabolism_Homo sapiens_hsa002301.24491933
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.22459334
62mRNA surveillance pathway_Homo sapiens_hsa030151.21197706
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17298555
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12699857
65Serotonergic synapse_Homo sapiens_hsa047261.12044204
66Amphetamine addiction_Homo sapiens_hsa050311.10068606
67Sulfur relay system_Homo sapiens_hsa041221.08900194
68Antigen processing and presentation_Homo sapiens_hsa046121.08093473
69Fatty acid metabolism_Homo sapiens_hsa012121.07247894
70Cardiac muscle contraction_Homo sapiens_hsa042601.06676265
71Caffeine metabolism_Homo sapiens_hsa002321.05143309
72Regulation of autophagy_Homo sapiens_hsa041401.04234351
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02762880
74Legionellosis_Homo sapiens_hsa051341.02543670
75Retinol metabolism_Homo sapiens_hsa008301.02292758
76Renin secretion_Homo sapiens_hsa049241.01530330
77Non-homologous end-joining_Homo sapiens_hsa034501.01520183
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00493833
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98311117
80Huntingtons disease_Homo sapiens_hsa050160.98042270
81Biosynthesis of amino acids_Homo sapiens_hsa012300.96801601
82Pyrimidine metabolism_Homo sapiens_hsa002400.95573746
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91989364
84Sulfur metabolism_Homo sapiens_hsa009200.90301555
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89944525
86Thyroid hormone synthesis_Homo sapiens_hsa049180.82071732
87Cholinergic synapse_Homo sapiens_hsa047250.81691456
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81321885
89Glutathione metabolism_Homo sapiens_hsa004800.81003031
90Fanconi anemia pathway_Homo sapiens_hsa034600.80131326
91Hedgehog signaling pathway_Homo sapiens_hsa043400.79989916
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78944390
93Bile secretion_Homo sapiens_hsa049760.76428419
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.74858937
95Chemical carcinogenesis_Homo sapiens_hsa052040.74418912
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.73772756
97Cocaine addiction_Homo sapiens_hsa050300.73574104
98Dopaminergic synapse_Homo sapiens_hsa047280.73194186
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71147267
100Asthma_Homo sapiens_hsa053100.69884226
101Folate biosynthesis_Homo sapiens_hsa007900.69467414
102Long-term depression_Homo sapiens_hsa047300.69398525
103Estrogen signaling pathway_Homo sapiens_hsa049150.69182552
104N-Glycan biosynthesis_Homo sapiens_hsa005100.68889840
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.67819231
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67541638
107DNA replication_Homo sapiens_hsa030300.65595058
108Renin-angiotensin system_Homo sapiens_hsa046140.65440509
109Long-term potentiation_Homo sapiens_hsa047200.65166775
110Ether lipid metabolism_Homo sapiens_hsa005650.64231887
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56873281
112Collecting duct acid secretion_Homo sapiens_hsa049660.53935268
113B cell receptor signaling pathway_Homo sapiens_hsa046620.53614895
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52842169
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52029714
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51804759
117Pancreatic secretion_Homo sapiens_hsa049720.51612622
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.51157093
119Ovarian steroidogenesis_Homo sapiens_hsa049130.51104972
120Arachidonic acid metabolism_Homo sapiens_hsa005900.50108712
121Synaptic vesicle cycle_Homo sapiens_hsa047210.49219717
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49051219
123beta-Alanine metabolism_Homo sapiens_hsa004100.48505352
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48392784
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47778713
126RNA degradation_Homo sapiens_hsa030180.46975213
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46489793
128Cell cycle_Homo sapiens_hsa041100.46370380
129Metabolic pathways_Homo sapiens_hsa011000.46304372
130Nucleotide excision repair_Homo sapiens_hsa034200.46268006
131Oxytocin signaling pathway_Homo sapiens_hsa049210.44768978
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44711597
133Base excision repair_Homo sapiens_hsa034100.43852372
134Insulin secretion_Homo sapiens_hsa049110.43425308
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42337080
136Fatty acid elongation_Homo sapiens_hsa000620.40491582
137Spliceosome_Homo sapiens_hsa030400.36418626
138Calcium signaling pathway_Homo sapiens_hsa040200.35301480
139Type I diabetes mellitus_Homo sapiens_hsa049400.33914731
140AMPK signaling pathway_Homo sapiens_hsa041520.33786347
141Endocytosis_Homo sapiens_hsa041440.30928722
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.29857783
143Proteasome_Homo sapiens_hsa030500.29024165
144cAMP signaling pathway_Homo sapiens_hsa040240.28547072
145VEGF signaling pathway_Homo sapiens_hsa043700.27363361
146Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25964486
147Salivary secretion_Homo sapiens_hsa049700.24220218
148Gastric acid secretion_Homo sapiens_hsa049710.23606147
149HIF-1 signaling pathway_Homo sapiens_hsa040660.22085420
150ABC transporters_Homo sapiens_hsa020100.20487664
151Sphingolipid metabolism_Homo sapiens_hsa006000.19743767
152Epstein-Barr virus infection_Homo sapiens_hsa051690.19590415
153Systemic lupus erythematosus_Homo sapiens_hsa053220.17363255
154Complement and coagulation cascades_Homo sapiens_hsa046100.16301242
155Inositol phosphate metabolism_Homo sapiens_hsa005620.13920574
156Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13575624
157Galactose metabolism_Homo sapiens_hsa000520.13091983
158Circadian entrainment_Homo sapiens_hsa047130.12815594
159Measles_Homo sapiens_hsa051620.12568949

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