ARL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). A vision-specific transcript, encoding long isoform BBS3L, has been described (PMID: 20333246). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)5.62506131
2rhodopsin mediated signaling pathway (GO:0016056)5.37245893
3retinal cone cell development (GO:0046549)4.70521041
4neuron cell-cell adhesion (GO:0007158)4.29050326
5protein localization to synapse (GO:0035418)4.26983527
6nonmotile primary cilium assembly (GO:0035058)4.14000880
7photoreceptor cell maintenance (GO:0045494)4.13892413
8synaptic vesicle exocytosis (GO:0016079)4.03829851
9pyrimidine nucleobase catabolic process (GO:0006208)4.00019802
10photoreceptor cell development (GO:0042461)3.88470364
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72528861
12eye photoreceptor cell development (GO:0042462)3.69230370
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.62223229
14detection of light stimulus involved in visual perception (GO:0050908)3.61054342
15detection of light stimulus involved in sensory perception (GO:0050962)3.61054342
16eye photoreceptor cell differentiation (GO:0001754)3.58154047
17photoreceptor cell differentiation (GO:0046530)3.58154047
18presynaptic membrane assembly (GO:0097105)3.50774416
19ATP synthesis coupled proton transport (GO:0015986)3.50673505
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.50673505
21axoneme assembly (GO:0035082)3.50133120
22chaperone-mediated protein transport (GO:0072321)3.48762377
23nucleobase catabolic process (GO:0046113)3.43997684
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43988937
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.39631729
26sensory perception of smell (GO:0007608)3.35818451
27positive regulation of mitochondrial fission (GO:0090141)3.33877592
28intraciliary transport (GO:0042073)3.29366428
29cilium movement (GO:0003341)3.29274949
30retinal rod cell development (GO:0046548)3.29068988
31mechanosensory behavior (GO:0007638)3.28934819
32auditory behavior (GO:0031223)3.28549045
33behavioral response to cocaine (GO:0048148)3.26319697
34axon ensheathment in central nervous system (GO:0032291)3.25081968
35central nervous system myelination (GO:0022010)3.25081968
36presynaptic membrane organization (GO:0097090)3.24606210
37regulation of short-term neuronal synaptic plasticity (GO:0048172)3.21246211
38GMP metabolic process (GO:0046037)3.19786023
39* protein localization to cilium (GO:0061512)3.19499099
40neuronal action potential propagation (GO:0019227)3.18569531
41regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.15610060
42regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.15610060
43regulation of cilium movement (GO:0003352)3.14202034
44behavioral response to nicotine (GO:0035095)3.13924321
45synaptic transmission, dopaminergic (GO:0001963)3.13786471
46negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12097285
47vocalization behavior (GO:0071625)3.11903066
48positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11473875
49fatty acid elongation (GO:0030497)3.10415737
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.08482506
51regulation of synaptic vesicle exocytosis (GO:2000300)3.02899653
52cilium or flagellum-dependent cell motility (GO:0001539)3.02470477
53cilium morphogenesis (GO:0060271)3.02179712
54glutamate secretion (GO:0014047)3.00105809
55neuron recognition (GO:0008038)2.99839895
56gamma-aminobutyric acid transport (GO:0015812)2.99809929
57histone H2A acetylation (GO:0043968)2.99250386
58epithelial cilium movement (GO:0003351)2.96296668
59startle response (GO:0001964)2.96198282
60* cilium organization (GO:0044782)2.93560988
61DNA double-strand break processing (GO:0000729)2.91860334
62response to histamine (GO:0034776)2.91792843
63energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.90543959
64ATP hydrolysis coupled proton transport (GO:0015991)2.90543959
65gamma-aminobutyric acid signaling pathway (GO:0007214)2.89443724
66striatum development (GO:0021756)2.89310928
67short-term memory (GO:0007614)2.89270270
68phototransduction (GO:0007602)2.88681135
69positive regulation of synapse assembly (GO:0051965)2.87798764
70respiratory electron transport chain (GO:0022904)2.87791522
71neuron-neuron synaptic transmission (GO:0007270)2.87268953
72regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.86749186
73axonemal dynein complex assembly (GO:0070286)2.86583101
74detection of light stimulus (GO:0009583)2.86204727
75long-chain fatty acid biosynthetic process (GO:0042759)2.86182033
76electron transport chain (GO:0022900)2.86135961
77protein neddylation (GO:0045116)2.86115267
78regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85645862
79neurofilament cytoskeleton organization (GO:0060052)2.85088764
80behavioral response to ethanol (GO:0048149)2.83675308
81negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.83336829
82regulation of dopamine metabolic process (GO:0042053)2.79458081
83regulation of catecholamine metabolic process (GO:0042069)2.79458081
84regulation of neurotransmitter uptake (GO:0051580)2.75881685
85postsynaptic membrane organization (GO:0001941)2.75495513
86detection of visible light (GO:0009584)2.74439522
87positive regulation of guanylate cyclase activity (GO:0031284)2.73136580
88protein complex biogenesis (GO:0070271)2.72624391
89regulation of voltage-gated calcium channel activity (GO:1901385)2.72095794
90* visual perception (GO:0007601)2.71932906
91synaptic vesicle endocytosis (GO:0048488)2.71705804
92transferrin transport (GO:0033572)2.70776987
93membrane hyperpolarization (GO:0060081)2.70582526
94positive regulation of membrane potential (GO:0045838)2.70574120
95neurotransmitter uptake (GO:0001504)2.70414581
96detection of calcium ion (GO:0005513)2.70072082
97righting reflex (GO:0060013)2.70027699
98microtubule severing (GO:0051013)2.69131311
99* sensory perception of light stimulus (GO:0050953)2.68630350
100long-term synaptic potentiation (GO:0060291)2.67628695
101left/right pattern formation (GO:0060972)2.65478423
102axonal fasciculation (GO:0007413)2.64959032
103DNA damage response, detection of DNA damage (GO:0042769)2.64639832
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64108933
105phototransduction, visible light (GO:0007603)2.63793353
106negative regulation of neurotransmitter transport (GO:0051589)2.63297451
107cullin deneddylation (GO:0010388)2.63283496
108regulation of synaptic vesicle transport (GO:1902803)2.62471004
109inositol phosphate catabolic process (GO:0071545)2.62271170
110transmission of nerve impulse (GO:0019226)2.62197547
111synaptic vesicle maturation (GO:0016188)2.59085379
112respiratory chain complex IV assembly (GO:0008535)2.58934113
113epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58536386
114negative regulation of dendrite development (GO:2000171)2.55480593
115neurotransmitter transport (GO:0006836)2.55300926
116dendrite development (GO:0016358)2.54637737
117* cilium assembly (GO:0042384)2.54415338
118glutamate receptor signaling pathway (GO:0007215)2.54065409
119regulation of glutamate receptor signaling pathway (GO:1900449)2.53984765
120neurotransmitter-gated ion channel clustering (GO:0072578)2.53380910
121synaptic transmission, glutamatergic (GO:0035249)2.53223208
122anterograde axon cargo transport (GO:0008089)2.51009093
123adult walking behavior (GO:0007628)2.50943678
124ganglion development (GO:0061548)2.49018290
125microtubule-based transport (GO:0010970)2.47783692
126regulation of microtubule-based movement (GO:0060632)2.45148620
127retinal ganglion cell axon guidance (GO:0031290)2.44819262
128sympathetic nervous system development (GO:0048485)2.43016831
129synapse assembly (GO:0007416)2.42815164
130regulation of feeding behavior (GO:0060259)2.41731774
131cytoskeleton-dependent intracellular transport (GO:0030705)2.41166290
132neurotransmitter secretion (GO:0007269)2.39345501
133acrosome reaction (GO:0007340)2.37797594
134microtubule-based movement (GO:0007018)2.36311414
135establishment of mitochondrion localization (GO:0051654)2.34179526
136anterograde synaptic vesicle transport (GO:0048490)2.33601379
137* cellular component assembly involved in morphogenesis (GO:0010927)2.32457895
138acrosome assembly (GO:0001675)2.31928723
139dendritic spine morphogenesis (GO:0060997)2.31257505
140peptidyl-histidine modification (GO:0018202)2.30802032
141ionotropic glutamate receptor signaling pathway (GO:0035235)2.29903078
142G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.29713296
143regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.29417672
144organelle disassembly (GO:1903008)2.27640361
145regulation of synapse structural plasticity (GO:0051823)2.27071415
146sequestering of actin monomers (GO:0042989)2.25269137
147response to pheromone (GO:0019236)2.25072870
148motile cilium assembly (GO:0044458)2.24799667
149phosphorylated carbohydrate dephosphorylation (GO:0046838)2.23698933
150inositol phosphate dephosphorylation (GO:0046855)2.23698933
151positive regulation of dendritic spine morphogenesis (GO:0061003)2.22889449
152adult behavior (GO:0030534)2.22170958
153calcium ion-dependent exocytosis (GO:0017156)2.21688227
154substrate-independent telencephalic tangential migration (GO:0021826)2.19342630
155substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.19342630
156regulation of dendritic spine morphogenesis (GO:0061001)2.19148282
157response to auditory stimulus (GO:0010996)2.18706377
158water-soluble vitamin biosynthetic process (GO:0042364)2.18378560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.97475404
2GBX2_23144817_ChIP-Seq_PC3_Human3.88643631
3TAF15_26573619_Chip-Seq_HEK293_Human2.76878702
4VDR_22108803_ChIP-Seq_LS180_Human2.48366542
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41540395
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36160557
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.30290252
8* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.28573879
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26078566
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25089211
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23526406
12FUS_26573619_Chip-Seq_HEK293_Human2.19101236
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15420467
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14342669
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.11646256
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11274302
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.10890763
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09631026
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06533483
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05851832
21* CBX2_27304074_Chip-Seq_ESCs_Mouse2.00906007
22IGF1R_20145208_ChIP-Seq_DFB_Human1.99125469
23REST_21632747_ChIP-Seq_MESCs_Mouse1.93884081
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.90468740
25RNF2_27304074_Chip-Seq_NSC_Mouse1.89307033
26P300_19829295_ChIP-Seq_ESCs_Human1.88577962
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88083271
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85782849
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80909529
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80909529
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78118570
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74177822
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73559541
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66028607
35* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.64182230
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63942620
37SMAD4_21799915_ChIP-Seq_A2780_Human1.63696563
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62868458
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60586847
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.59554807
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58483178
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58028020
43* EST1_17652178_ChIP-ChIP_JURKAT_Human1.57429934
44* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55331555
45ER_23166858_ChIP-Seq_MCF-7_Human1.53404860
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.53213345
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52984809
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52127002
49ELK1_19687146_ChIP-ChIP_HELA_Human1.49803232
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.47407571
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.46902852
52AR_21572438_ChIP-Seq_LNCaP_Human1.46776229
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43999337
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42548682
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42039199
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41397612
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38099129
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.37640524
59CBP_20019798_ChIP-Seq_JUKART_Human1.35408947
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35408947
61CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32597155
62EWS_26573619_Chip-Seq_HEK293_Human1.32296570
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30053559
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29279019
65CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.28919301
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28885550
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.27221146
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27027562
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26986530
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26441002
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26121673
72ZNF274_21170338_ChIP-Seq_K562_Hela1.24876309
73JUN_21703547_ChIP-Seq_K562_Human1.24307196
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.21838271
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21397921
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.21102540
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20595449
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.18010717
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16777860
80STAT3_23295773_ChIP-Seq_U87_Human1.16561869
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.16451050
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14865668
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14680696
84MYC_18940864_ChIP-ChIP_HL60_Human1.13428182
85KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13038174
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12921151
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12128048
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.11200391
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11008551
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10669981
91* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10646091
92AR_25329375_ChIP-Seq_VCAP_Human1.10364935
93IRF1_19129219_ChIP-ChIP_H3396_Human1.08763290
94RUNX2_22187159_ChIP-Seq_PCA_Human1.08266277
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08094121
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08025114
97TCF4_22108803_ChIP-Seq_LS180_Human1.06814818
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.06770684
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06735760
100* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06196561
101TCF4_23295773_ChIP-Seq_U87_Human1.05894082
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05459293
103* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05080290
104BCAT_22108803_ChIP-Seq_LS180_Human1.04429517
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04130360
106TP53_18474530_ChIP-ChIP_U2OS_Human1.02880610
107POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00435829
108CMYC_18555785_Chip-Seq_ESCs_Mouse0.99846518
109SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99689116
110IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99487035
111* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99227032
112SOX9_26525672_Chip-Seq_HEART_Mouse0.98925891
113NANOG_19829295_ChIP-Seq_ESCs_Human0.98804849
114SOX2_19829295_ChIP-Seq_ESCs_Human0.98804849
115P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97976033
116* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97848815
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97387313
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96343967
119PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96289016
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95872480
121KDM2B_26808549_Chip-Seq_REH_Human0.95851632
122* ETS1_20019798_ChIP-Seq_JURKAT_Human0.95646094
123E2F1_18555785_Chip-Seq_ESCs_Mouse0.95603781
124P53_22387025_ChIP-Seq_ESCs_Mouse0.95350162
125DROSHA_22980978_ChIP-Seq_HELA_Human0.94796325
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94067958
127REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93297001
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92914729

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.57484857
2MP0005551_abnormal_eye_electrophysiolog3.59922340
3MP0001984_abnormal_olfaction3.08780378
4MP0004270_analgesia2.79882879
5MP0006072_abnormal_retinal_apoptosis2.79160241
6MP0004859_abnormal_synaptic_plasticity2.76706510
7MP0006276_abnormal_autonomic_nervous2.73600951
8MP0005423_abnormal_somatic_nervous2.70383349
9MP0003635_abnormal_synaptic_transmissio2.55466895
10MP0001529_abnormal_vocalization2.49745728
11MP0005253_abnormal_eye_physiology2.41738591
12MP0002734_abnormal_mechanical_nocicepti2.38323443
13MP0001968_abnormal_touch/_nociception2.37960889
14MP0009745_abnormal_behavioral_response2.32710416
15MP0009046_muscle_twitch2.32477670
16MP0002272_abnormal_nervous_system2.28877649
17MP0002064_seizures2.22480527
18MP0002736_abnormal_nociception_after2.21080190
19MP0002063_abnormal_learning/memory/cond2.15872287
20MP0003011_delayed_dark_adaptation2.14103203
21MP0002572_abnormal_emotion/affect_behav2.09844668
22MP0001905_abnormal_dopamine_level2.04301783
23MP0001486_abnormal_startle_reflex2.00481458
24MP0002735_abnormal_chemical_nociception1.91128093
25MP0002638_abnormal_pupillary_reflex1.88889019
26MP0000778_abnormal_nervous_system1.86732146
27MP0001188_hyperpigmentation1.81301573
28MP0001986_abnormal_taste_sensitivity1.80928458
29MP0005394_taste/olfaction_phenotype1.71367202
30MP0005499_abnormal_olfactory_system1.71367202
31MP0008789_abnormal_olfactory_epithelium1.70679448
32MP0002184_abnormal_innervation1.67374962
33MP0002067_abnormal_sensory_capabilities1.65767509
34MP0001440_abnormal_grooming_behavior1.64617710
35MP0005645_abnormal_hypothalamus_physiol1.64559215
36MP0003122_maternal_imprinting1.63938038
37MP0005646_abnormal_pituitary_gland1.63762207
38MP0002822_catalepsy1.58547121
39MP0001970_abnormal_pain_threshold1.57658702
40* MP0002882_abnormal_neuron_morphology1.55119601
41MP0005187_abnormal_penis_morphology1.54680086
42* MP0002752_abnormal_somatic_nervous1.52729836
43* MP0005195_abnormal_posterior_eye1.52479402
44MP0002229_neurodegeneration1.50540999
45MP0004924_abnormal_behavior1.50182279
46MP0005386_behavior/neurological_phenoty1.50182279
47MP0002102_abnormal_ear_morphology1.47599716
48MP0002557_abnormal_social/conspecific_i1.46135032
49MP0004142_abnormal_muscle_tone1.41330285
50MP0001501_abnormal_sleep_pattern1.39327984
51MP0002733_abnormal_thermal_nociception1.37478262
52MP0001502_abnormal_circadian_rhythm1.35693995
53MP0000631_abnormal_neuroendocrine_gland1.32616174
54MP0004043_abnormal_pH_regulation1.31358347
55MP0008058_abnormal_DNA_repair1.30824384
56MP0003890_abnormal_embryonic-extraembry1.29858386
57MP0006292_abnormal_olfactory_placode1.29040875
58MP0005410_abnormal_fertilization1.25186499
59MP0000955_abnormal_spinal_cord1.18139004
60MP0010386_abnormal_urinary_bladder1.17349814
61MP0005623_abnormal_meninges_morphology1.16621653
62MP0001963_abnormal_hearing_physiology1.15007760
63MP0002909_abnormal_adrenal_gland1.11038215
64MP0005391_vision/eye_phenotype1.10719921
65MP0004742_abnormal_vestibular_system1.09925938
66MP0005248_abnormal_Harderian_gland1.09843013
67MP0009780_abnormal_chondrocyte_physiolo1.07872683
68MP0002653_abnormal_ependyma_morphology1.07691753
69MP0004811_abnormal_neuron_physiology1.07545790
70MP0008877_abnormal_DNA_methylation1.07461049
71MP0002066_abnormal_motor_capabilities/c1.07290279
72MP0002152_abnormal_brain_morphology1.05203176
73MP0003937_abnormal_limbs/digits/tail_de1.03417542
74MP0001485_abnormal_pinna_reflex1.03400281
75MP0003195_calcinosis1.03020212
76MP0000566_synostosis1.02395949
77MP0004133_heterotaxia1.02238247
78MP0003787_abnormal_imprinting1.00541983
79MP0000516_abnormal_urinary_system0.98756173
80MP0005367_renal/urinary_system_phenotyp0.98756173
81MP0001293_anophthalmia0.97765012
82MP0003121_genomic_imprinting0.97519843
83MP0005084_abnormal_gallbladder_morpholo0.97104490
84MP0000026_abnormal_inner_ear0.97078767
85MP0000569_abnormal_digit_pigmentation0.96450120
86MP0002876_abnormal_thyroid_physiology0.93748859
87MP0002751_abnormal_autonomic_nervous0.93663030
88MP0003634_abnormal_glial_cell0.93305142
89MP0003950_abnormal_plasma_membrane0.93040262
90MP0003567_abnormal_fetal_cardiomyocyte0.92224645
91MP0008875_abnormal_xenobiotic_pharmacok0.92071019
92MP0002234_abnormal_pharynx_morphology0.91457089
93MP0002837_dystrophic_cardiac_calcinosis0.91301674
94MP0004885_abnormal_endolymph0.90859366
95MP0001286_abnormal_eye_development0.90341726
96MP0000647_abnormal_sebaceous_gland0.88895561
97MP0002090_abnormal_vision0.88502364
98MP0004215_abnormal_myocardial_fiber0.87657924
99MP0002938_white_spotting0.86638933
100MP0008569_lethality_at_weaning0.84130815
101MP0001299_abnormal_eye_distance/0.83869725
102MP0003698_abnormal_male_reproductive0.82812311
103MP0004145_abnormal_muscle_electrophysio0.81802464
104MP0006035_abnormal_mitochondrial_morpho0.81250108
105MP0005409_darkened_coat_color0.81194113
106MP0003329_amyloid_beta_deposits0.79853069
107MP0003861_abnormal_nervous_system0.79326827
108MP0003718_maternal_effect0.75783586
109MP0003119_abnormal_digestive_system0.75697094
110MP0000049_abnormal_middle_ear0.75143270
111MP0001324_abnormal_eye_pigmentation0.74878321
112MP0005171_absent_coat_pigmentation0.74139601
113MP0004233_abnormal_muscle_weight0.70795164
114MP0002069_abnormal_eating/drinking_beha0.68681436
115MP0003631_nervous_system_phenotype0.68147033
116MP0002160_abnormal_reproductive_system0.67523736
117MP0003123_paternal_imprinting0.65372787
118MP0001664_abnormal_digestion0.64912615
119MP0004085_abnormal_heartbeat0.64837270
120MP0002332_abnormal_exercise_endurance0.64751725
121MP0000751_myopathy0.62899213
122MP0002233_abnormal_nose_morphology0.62603978
123MP0003633_abnormal_nervous_system0.62143154
124MP0000920_abnormal_myelination0.61619851
125MP0003632_abnormal_nervous_system0.59855125

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.54871035
2* Gait imbalance (HP:0002141)4.29198739
3* Medial flaring of the eyebrow (HP:0010747)4.25222498
4Acute necrotizing encephalopathy (HP:0006965)4.16838533
5* Congenital primary aphakia (HP:0007707)4.13432534
6Bony spicule pigmentary retinopathy (HP:0007737)4.04759767
7Abnormal rod and cone electroretinograms (HP:0008323)4.03562563
8Focal motor seizures (HP:0011153)3.96898180
9Abnormality of macular pigmentation (HP:0008002)3.88355878
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.86834775
11Abnormal mitochondria in muscle tissue (HP:0008316)3.80093317
12* Nephrogenic diabetes insipidus (HP:0009806)3.79416755
13Progressive macrocephaly (HP:0004481)3.57656831
14Central scotoma (HP:0000603)3.43228464
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.35373504
16* Vaginal atresia (HP:0000148)3.31295356
17Dyschromatopsia (HP:0007641)3.31096866
18* Genital tract atresia (HP:0001827)3.30328030
19Abnormal respiratory motile cilium physiology (HP:0012261)3.26536065
20Optic disc pallor (HP:0000543)3.25285885
21Abnormal ciliary motility (HP:0012262)3.24958478
22Atonic seizures (HP:0010819)3.13716497
23Acute encephalopathy (HP:0006846)3.12354297
24Attenuation of retinal blood vessels (HP:0007843)3.10630032
25Mitochondrial inheritance (HP:0001427)3.05837592
26Severe visual impairment (HP:0001141)2.95013309
27* Poor coordination (HP:0002370)2.94622629
28Abnormal respiratory motile cilium morphology (HP:0005938)2.92129220
29Abnormal respiratory epithelium morphology (HP:0012253)2.92129220
30Decreased central vision (HP:0007663)2.87927977
31Epileptic encephalopathy (HP:0200134)2.84002443
32Pancreatic fibrosis (HP:0100732)2.82743164
33Myokymia (HP:0002411)2.81446401
34Tubulointerstitial nephritis (HP:0001970)2.78959977
35Abnormality of midbrain morphology (HP:0002418)2.69488027
36Molar tooth sign on MRI (HP:0002419)2.69488027
37Scotoma (HP:0000575)2.69025665
38True hermaphroditism (HP:0010459)2.68923545
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.68611640
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.68611640
41Abolished electroretinogram (ERG) (HP:0000550)2.67265748
42Febrile seizures (HP:0002373)2.66587576
43Visual hallucinations (HP:0002367)2.65044802
44Absent/shortened dynein arms (HP:0200106)2.59007759
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.59007759
46Focal seizures (HP:0007359)2.57482549
47Pancreatic cysts (HP:0001737)2.57009338
48Rhinitis (HP:0012384)2.56577370
49Chorioretinal atrophy (HP:0000533)2.56427638
50Drooling (HP:0002307)2.55013936
51Nephronophthisis (HP:0000090)2.50986170
52Chronic bronchitis (HP:0004469)2.49598489
53Pendular nystagmus (HP:0012043)2.48837955
54Increased CSF lactate (HP:0002490)2.46734385
55Occipital encephalocele (HP:0002085)2.46704438
56Retinal dysplasia (HP:0007973)2.46196902
57Pigmentary retinal degeneration (HP:0001146)2.45221296
58* Aplasia/Hypoplasia of the lens (HP:0008063)2.44559647
59* Retinitis pigmentosa (HP:0000510)2.44294354
60Absence seizures (HP:0002121)2.43779535
61Hepatocellular necrosis (HP:0001404)2.42363089
62* Specific learning disability (HP:0001328)2.39800421
63Progressive cerebellar ataxia (HP:0002073)2.39581858
64Chronic hepatic failure (HP:0100626)2.39300234
65Leukodystrophy (HP:0002415)2.36102956
66Postaxial foot polydactyly (HP:0001830)2.34955609
67Failure to thrive in infancy (HP:0001531)2.33169221
68Abnormality of the corticospinal tract (HP:0002492)2.31058998
69Dialeptic seizures (HP:0011146)2.24996388
70Excessive salivation (HP:0003781)2.24766255
71Abnormality of glycolysis (HP:0004366)2.24316173
72Increased serum pyruvate (HP:0003542)2.24316173
73* Type II diabetes mellitus (HP:0005978)2.23250435
74Neuroendocrine neoplasm (HP:0100634)2.22730268
75Pheochromocytoma (HP:0002666)2.18681518
76* Photophobia (HP:0000613)2.16426651
77Insidious onset (HP:0003587)2.11601751
78Termporal pattern (HP:0011008)2.11601751
79Abnormal hair whorl (HP:0010721)2.10926235
80Choroideremia (HP:0001139)2.10630123
81Bronchiectasis (HP:0002110)2.09028472
82Limb dystonia (HP:0002451)2.08739246
83Increased hepatocellular lipid droplets (HP:0006565)2.07651432
84Hyperventilation (HP:0002883)2.03665250
85* Postaxial hand polydactyly (HP:0001162)2.02259069
86Median cleft lip (HP:0000161)1.99654524
87Hypothermia (HP:0002045)1.99339223
88Chorioretinal coloboma (HP:0000567)1.99049651
89Amyotrophic lateral sclerosis (HP:0007354)1.98712768
90Truncal ataxia (HP:0002078)1.96598258
91Intestinal atresia (HP:0011100)1.96329739
92Atrophy/Degeneration involving motor neurons (HP:0007373)1.95166943
93Colon cancer (HP:0003003)1.93717759
94Labial hypoplasia (HP:0000066)1.91678442
95Broad-based gait (HP:0002136)1.89585915
96Constricted visual fields (HP:0001133)1.87813050
97Abnormality of the renal medulla (HP:0100957)1.87343111
98Cone-rod dystrophy (HP:0000548)1.87020526
99Anencephaly (HP:0002323)1.86471084
100Generalized tonic-clonic seizures (HP:0002069)1.86156227
101Preaxial hand polydactyly (HP:0001177)1.84717159
102Sclerocornea (HP:0000647)1.84146849
103Delusions (HP:0000746)1.83959995
104Abnormality of the labia minora (HP:0012880)1.83727227
105Amblyopia (HP:0000646)1.83652327
106Muscular hypotonia of the trunk (HP:0008936)1.83156490
107Hypoplastic female external genitalia (HP:0012815)1.82703416
108Keratoconus (HP:0000563)1.81668800
109Increased corneal curvature (HP:0100692)1.81668800
110Volvulus (HP:0002580)1.81427256
111Exercise intolerance (HP:0003546)1.80677121
112Hypsarrhythmia (HP:0002521)1.80027071
113Renal Fanconi syndrome (HP:0001994)1.79807889
114Gaze-evoked nystagmus (HP:0000640)1.79309581
115Cerebral edema (HP:0002181)1.79094578
116Methylmalonic acidemia (HP:0002912)1.78516427
117Epileptiform EEG discharges (HP:0011182)1.77934988
118Lissencephaly (HP:0001339)1.77079670
119* Broad foot (HP:0001769)1.76980742
120EEG with generalized epileptiform discharges (HP:0011198)1.76204731
121Oligodactyly (hands) (HP:0001180)1.74697241
122Dyskinesia (HP:0100660)1.73920186
123Optic nerve hypoplasia (HP:0000609)1.73148466
124Abnormality of the renal cortex (HP:0011035)1.72247489
125Spastic tetraplegia (HP:0002510)1.71891743
126X-linked dominant inheritance (HP:0001423)1.71818798
127Poor suck (HP:0002033)1.71372925
128Congenital hepatic fibrosis (HP:0002612)1.69804804
129Hepatic necrosis (HP:0002605)1.69795672
130Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69401672
131Cystic liver disease (HP:0006706)1.68291045
132Male pseudohermaphroditism (HP:0000037)1.67999301
133Scrotal hypoplasia (HP:0000046)1.65887284
134Lipid accumulation in hepatocytes (HP:0006561)1.64349416
135* Aganglionic megacolon (HP:0002251)1.63461167
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.63424558
137Abnormality of the anterior horn cell (HP:0006802)1.63198350
138Degeneration of anterior horn cells (HP:0002398)1.63198350
139* Decreased testicular size (HP:0008734)1.63043991
140Stenosis of the external auditory canal (HP:0000402)1.62876482
141Narrow forehead (HP:0000341)1.61030488
142Thyroid carcinoma (HP:0002890)1.59554617
143Renal hypoplasia (HP:0000089)1.59282396
144Facial cleft (HP:0002006)1.58753854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.88751903
2MAP3K43.09781963
3MAP2K72.95027141
4FRK2.79032133
5MAP4K22.72670395
6NTRK32.66701519
7TRIM282.62097410
8PNCK2.60900789
9PLK22.44878669
10CDK192.19386811
11PBK2.13015503
12INSRR2.08535484
13OXSR12.04325130
14ARAF2.02366888
15EPHA41.99630606
16STK391.96612215
17MARK11.95361226
18MAP3K121.94147369
19BCR1.78746450
20WNK31.65916016
21GRK51.65395097
22NTRK21.62711505
23MINK11.58689618
24NME11.55082403
25PLK41.50447261
26MAPK131.50359659
27EPHA31.43304433
28TNIK1.41646855
29NUAK11.41189652
30GRK71.36961908
31AKT31.32864750
32GRK11.32557728
33MAP3K91.31585274
34PINK11.31351271
35BRAF1.30016440
36CCNB11.28924695
37STK38L1.28212814
38BCKDK1.19646751
39UHMK11.18519918
40MAP2K41.18385486
41MUSK1.18352105
42CSNK1G31.17696225
43NEK11.16378125
44DYRK21.16283795
45CAMK2A1.14341103
46BMPR21.12054084
47TSSK61.09105656
48MAPKAPK51.08258378
49WNK41.07611038
50CAMK2B1.06535904
51BUB11.03726498
52SGK2231.02815773
53SGK4941.02815773
54PLK31.02259229
55CSNK1G21.00198231
56ADRBK10.98176832
57PRKCG0.95954296
58PTK2B0.93874132
59CDK140.93453704
60ZAK0.92657892
61CDK50.92076897
62PRPF4B0.90020236
63LIMK10.89867887
64PHKG20.89856048
65PHKG10.89856048
66CSNK1A1L0.87610680
67STK240.86989152
68FGFR20.85085403
69DYRK1A0.85022329
70DAPK20.84093582
71CAMK2D0.84062739
72CDK180.84062705
73ADRBK20.83542517
74DAPK10.83209358
75MAPK150.79919397
76MKNK10.78980164
77NTRK10.78609265
78CDK150.78391542
79BMPR1B0.74073595
80MKNK20.74024712
81STK160.73640399
82DYRK30.72773073
83SRPK10.70856336
84CDK11A0.70465191
85CSNK1G10.67631359
86EIF2AK10.67175376
87ROCK20.65921445
88TAF10.65601886
89FER0.64916744
90VRK10.63904347
91PRKCE0.63562122
92KSR10.63333223
93WEE10.63197029
94NEK60.63185901
95PDK40.62977717
96PDK30.62977717
97PLK10.62124857
98TESK10.61403921
99PAK60.59618644
100ACVR1B0.59264953
101CAMK2G0.59037606
102CAMKK20.57794738
103CDK30.57303773
104ERBB30.57093921
105PIK3CA0.56932115
106YES10.53464596
107TTK0.52927555
108TIE10.52830396
109MOS0.52455915
110EIF2AK30.52327093
111PKN10.51555454
112MST40.48501150
113PRKACA0.47908077
114FGR0.47716145
115MYLK0.47557487
116AURKA0.44910046
117PAK30.43589729
118SGK20.42454076
119FES0.42331389
120VRK20.41176288
121EPHB20.41017972
122ERBB40.40002492
123CSNK1E0.39825216
124MAP3K60.38462196
125SIK30.38054331
126PASK0.37865271
127TLK10.37479105
128PRKCI0.35437110
129PDK20.34204796
130KSR20.33652124
131BRSK20.30117053
132CSNK1A10.29857384
133CDC70.28177367

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.41816082
2Oxidative phosphorylation_Homo sapiens_hsa001903.48122870
3Synaptic vesicle cycle_Homo sapiens_hsa047213.06783277
4Nicotine addiction_Homo sapiens_hsa050332.95755039
5Olfactory transduction_Homo sapiens_hsa047402.90756692
6Parkinsons disease_Homo sapiens_hsa050122.75397051
7Collecting duct acid secretion_Homo sapiens_hsa049662.71473356
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30614326
9Alzheimers disease_Homo sapiens_hsa050102.25717025
10Huntingtons disease_Homo sapiens_hsa050162.24223301
11GABAergic synapse_Homo sapiens_hsa047272.22972578
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00901259
13Morphine addiction_Homo sapiens_hsa050321.95246036
14Vibrio cholerae infection_Homo sapiens_hsa051101.91830044
15Circadian entrainment_Homo sapiens_hsa047131.87086914
16Serotonergic synapse_Homo sapiens_hsa047261.82474808
17Glutamatergic synapse_Homo sapiens_hsa047241.80833191
18Dopaminergic synapse_Homo sapiens_hsa047281.76518201
19Taste transduction_Homo sapiens_hsa047421.73597825
20Proteasome_Homo sapiens_hsa030501.63041928
21Amphetamine addiction_Homo sapiens_hsa050311.60396519
22Cardiac muscle contraction_Homo sapiens_hsa042601.58896373
23Vitamin B6 metabolism_Homo sapiens_hsa007501.58075556
24Long-term potentiation_Homo sapiens_hsa047201.48768402
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47501517
26Propanoate metabolism_Homo sapiens_hsa006401.47352812
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38574128
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37997001
29Insulin secretion_Homo sapiens_hsa049111.32385530
30Cholinergic synapse_Homo sapiens_hsa047251.30169653
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28883871
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28813143
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28419754
34Non-homologous end-joining_Homo sapiens_hsa034501.23238695
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22908562
36Protein export_Homo sapiens_hsa030601.21615236
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18594701
38Long-term depression_Homo sapiens_hsa047301.17990803
39Selenocompound metabolism_Homo sapiens_hsa004501.17226493
40Renin secretion_Homo sapiens_hsa049241.16679134
41Salivary secretion_Homo sapiens_hsa049701.16328494
42Fatty acid elongation_Homo sapiens_hsa000621.10478589
43Cocaine addiction_Homo sapiens_hsa050301.10339250
44RNA transport_Homo sapiens_hsa030131.05334407
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03935176
46Fanconi anemia pathway_Homo sapiens_hsa034601.00426277
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98378059
48Calcium signaling pathway_Homo sapiens_hsa040200.98366090
49Oocyte meiosis_Homo sapiens_hsa041140.97197209
50Gastric acid secretion_Homo sapiens_hsa049710.97064407
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95817162
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95624541
53Mismatch repair_Homo sapiens_hsa034300.94965132
54Axon guidance_Homo sapiens_hsa043600.92563607
55RNA polymerase_Homo sapiens_hsa030200.91305559
56Ether lipid metabolism_Homo sapiens_hsa005650.90887025
57Folate biosynthesis_Homo sapiens_hsa007900.89954697
58Pyruvate metabolism_Homo sapiens_hsa006200.89514430
59beta-Alanine metabolism_Homo sapiens_hsa004100.89342072
60Basal transcription factors_Homo sapiens_hsa030220.87261172
61Oxytocin signaling pathway_Homo sapiens_hsa049210.87222854
62Homologous recombination_Homo sapiens_hsa034400.85589017
63Alcoholism_Homo sapiens_hsa050340.84174780
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.84060104
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81952452
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81866556
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81083639
68Gap junction_Homo sapiens_hsa045400.79345792
69Caffeine metabolism_Homo sapiens_hsa002320.77974527
70Peroxisome_Homo sapiens_hsa041460.77473313
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73215123
72Rheumatoid arthritis_Homo sapiens_hsa053230.70649930
73Purine metabolism_Homo sapiens_hsa002300.70628457
74Steroid biosynthesis_Homo sapiens_hsa001000.69950723
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69360010
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69288170
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68955063
78GnRH signaling pathway_Homo sapiens_hsa049120.68725480
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68443743
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.68082227
81Hippo signaling pathway_Homo sapiens_hsa043900.68032582
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65364691
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64721931
84Melanogenesis_Homo sapiens_hsa049160.64453687
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.64344160
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60531241
87cAMP signaling pathway_Homo sapiens_hsa040240.58439288
88Fatty acid metabolism_Homo sapiens_hsa012120.56569237
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56042364
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.55565115
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55476681
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53623298
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53117564
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52638843
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51405245
96Ovarian steroidogenesis_Homo sapiens_hsa049130.51037085
97Chemical carcinogenesis_Homo sapiens_hsa052040.50580896
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49375823
99Pyrimidine metabolism_Homo sapiens_hsa002400.49097159
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.47271698
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46000138
102Ras signaling pathway_Homo sapiens_hsa040140.44657392
103Phagosome_Homo sapiens_hsa041450.41516463
104Circadian rhythm_Homo sapiens_hsa047100.39356745
105Cell cycle_Homo sapiens_hsa041100.38286515
106Wnt signaling pathway_Homo sapiens_hsa043100.37750737
107Hedgehog signaling pathway_Homo sapiens_hsa043400.37587717
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35571768
109ErbB signaling pathway_Homo sapiens_hsa040120.35497848
110Arginine and proline metabolism_Homo sapiens_hsa003300.35338134
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33375226
112Estrogen signaling pathway_Homo sapiens_hsa049150.32957269
113Pancreatic secretion_Homo sapiens_hsa049720.32146199
114Linoleic acid metabolism_Homo sapiens_hsa005910.30991198
115Butanoate metabolism_Homo sapiens_hsa006500.29448576
116Metabolic pathways_Homo sapiens_hsa011000.28369184
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28157664
118Sulfur metabolism_Homo sapiens_hsa009200.27491942
119Sphingolipid metabolism_Homo sapiens_hsa006000.27194725
120RNA degradation_Homo sapiens_hsa030180.26308779
121Thyroid hormone synthesis_Homo sapiens_hsa049180.24455247
122MAPK signaling pathway_Homo sapiens_hsa040100.24081112
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23888475
124Nucleotide excision repair_Homo sapiens_hsa034200.23597487
125mRNA surveillance pathway_Homo sapiens_hsa030150.21979704
126Type I diabetes mellitus_Homo sapiens_hsa049400.21958676
127Glucagon signaling pathway_Homo sapiens_hsa049220.21572552
128Dorso-ventral axis formation_Homo sapiens_hsa043200.21324210
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20036459
130Regulation of autophagy_Homo sapiens_hsa041400.19822890
131Tight junction_Homo sapiens_hsa045300.19617338
132Dilated cardiomyopathy_Homo sapiens_hsa054140.19067162
133Spliceosome_Homo sapiens_hsa030400.18982165
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18704304
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18278544

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