ARL4C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ADP-ribosylation factor-like 4C is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4C is closely similar to ARL4A and ARL4D and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in cholesterol transport. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)7.07162558
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.07162558
3negative T cell selection (GO:0043383)4.57162702
4positive thymic T cell selection (GO:0045059)4.50936190
5positive T cell selection (GO:0043368)4.42609369
6negative thymic T cell selection (GO:0045060)4.36077041
7thymic T cell selection (GO:0045061)4.15198146
8interferon-gamma production (GO:0032609)4.05990043
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.02173420
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.98795289
11positive regulation of gamma-delta T cell activation (GO:0046645)3.95018510
12T cell selection (GO:0045058)3.93096903
13regulation of T cell tolerance induction (GO:0002664)3.67937075
14activated T cell proliferation (GO:0050798)3.38564639
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.38425252
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.38425252
17regulation of interleukin-2 biosynthetic process (GO:0045076)3.37689708
18T cell migration (GO:0072678)3.32032919
19regulation of alpha-beta T cell proliferation (GO:0046640)3.26386411
20T cell receptor signaling pathway (GO:0050852)3.25081075
21regulation of B cell receptor signaling pathway (GO:0050855)3.22901967
22response to muramyl dipeptide (GO:0032495)3.21662450
23regulation of gamma-delta T cell differentiation (GO:0045586)3.13185938
24negative regulation of interleukin-12 production (GO:0032695)3.09373757
25negative regulation of type 2 immune response (GO:0002829)3.05088434
26regulation of regulatory T cell differentiation (GO:0045589)3.03256205
27positive regulation by symbiont of host defense response (GO:0052509)3.01997465
28modulation by symbiont of host defense response (GO:0052031)3.01997465
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.01997465
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.01997465
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.01997465
32modulation by symbiont of host immune response (GO:0052553)3.01997465
33response to interleukin-15 (GO:0070672)3.00727030
34antigen processing and presentation of endogenous antigen (GO:0019883)2.97114231
35positive regulation of alpha-beta T cell proliferation (GO:0046641)2.95853220
36antigen processing and presentation via MHC class Ib (GO:0002475)2.95375973
37regulation of isotype switching to IgG isotypes (GO:0048302)2.94922217
38regulation of interleukin-12 biosynthetic process (GO:0045075)2.94875836
39leukocyte aggregation (GO:0070486)2.92086575
40T cell costimulation (GO:0031295)2.89215200
41heterotypic cell-cell adhesion (GO:0034113)2.88427694
42regulation of B cell differentiation (GO:0045577)2.87522045
43neutrophil activation involved in immune response (GO:0002283)2.87189169
44negative regulation of T cell mediated immunity (GO:0002710)2.86905516
45regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.86150950
46regulation of natural killer cell mediated immunity (GO:0002715)2.86150950
47detection of other organism (GO:0098543)2.86123364
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86090403
49regulation of gamma-delta T cell activation (GO:0046643)2.85854231
50lymphocyte costimulation (GO:0031294)2.84024563
51detection of bacterium (GO:0016045)2.82787802
52negative regulation of phagocytosis (GO:0050765)2.79513132
53NIK/NF-kappaB signaling (GO:0038061)2.79088214
54regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.77616938
55leukocyte cell-cell adhesion (GO:0007159)2.74685354
56antigen receptor-mediated signaling pathway (GO:0050851)2.74218804
57positive regulation of granulocyte differentiation (GO:0030854)2.73911229
58cellular response to interleukin-15 (GO:0071350)2.72045050
59T cell homeostasis (GO:0043029)2.71254265
60tolerance induction (GO:0002507)2.68647630
61T cell differentiation (GO:0030217)2.68156091
62regulation of T cell mediated cytotoxicity (GO:0001914)2.67444462
63positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.66695174
64cell adhesion mediated by integrin (GO:0033627)2.66458663
65positive regulation of tolerance induction (GO:0002645)2.66296010
66regulation of isotype switching (GO:0045191)2.65541366
67regulation of cell killing (GO:0031341)2.65510154
68negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.65048694
69regulation of tolerance induction (GO:0002643)2.64880845
70hepatocyte apoptotic process (GO:0097284)2.63279861
71positive regulation of T cell differentiation in thymus (GO:0033089)2.63097456
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59800601
73substrate-dependent cell migration (GO:0006929)2.58952877
74regulation of interleukin-4 production (GO:0032673)2.57385748
75positive regulation of mast cell activation (GO:0033005)2.56916779
76mast cell activation (GO:0045576)2.56899653
77regulation of alpha-beta T cell activation (GO:0046634)2.56807623
78negative regulation of lymphocyte mediated immunity (GO:0002707)2.53180245
79positive regulation of cell killing (GO:0031343)2.50542784
80germ cell migration (GO:0008354)2.49253846
81type I interferon signaling pathway (GO:0060337)2.47879645
82cellular response to type I interferon (GO:0071357)2.47879645
83regulation of T cell receptor signaling pathway (GO:0050856)2.47424580
84lymphocyte migration (GO:0072676)2.46680751
85dendritic cell chemotaxis (GO:0002407)2.45554206
86response to type I interferon (GO:0034340)2.44936680
87microglial cell activation (GO:0001774)2.44902207
88clathrin coat assembly (GO:0048268)2.43502537
89response to laminar fluid shear stress (GO:0034616)2.42802636
90positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.41959370
91positive regulation of natural killer cell mediated immunity (GO:0002717)2.41959370
92regulation of interferon-beta biosynthetic process (GO:0045357)2.41221920
93macrophage activation involved in immune response (GO:0002281)2.40174325
94cellular extravasation (GO:0045123)2.39331040
95positive regulation of isotype switching (GO:0045830)2.38777766
96positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.38654593
97regulation of defense response to virus by virus (GO:0050690)2.38165334
98protein localization to endosome (GO:0036010)2.37018204
99negative regulation of leukocyte mediated immunity (GO:0002704)2.35568736
100regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.35194877
101positive regulation of antigen processing and presentation (GO:0002579)2.34624598
102positive regulation of interleukin-2 production (GO:0032743)2.34281390
103positive regulation of astrocyte differentiation (GO:0048711)2.29740544
104T cell proliferation (GO:0042098)2.29566292
105immune response-activating cell surface receptor signaling pathway (GO:0002429)2.29015911
106leukocyte tethering or rolling (GO:0050901)2.28775652
107alpha-beta T cell activation (GO:0046631)2.25533331
108regulation of hypersensitivity (GO:0002883)2.25310502
109natural killer cell differentiation (GO:0001779)2.24955226
110myeloid dendritic cell differentiation (GO:0043011)2.24568694
111cortical actin cytoskeleton organization (GO:0030866)2.22319860
112myeloid dendritic cell activation (GO:0001773)2.20246561
113alpha-beta T cell differentiation (GO:0046632)2.18481478
114signal complex assembly (GO:0007172)2.17851449
115neutrophil activation (GO:0042119)2.17095730
116JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.15512068
117tyrosine phosphorylation of STAT protein (GO:0007260)2.14002542
118negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.13315016
119T-helper cell differentiation (GO:0042093)2.11472347
120CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.11472347
121cytoplasmic mRNA processing body assembly (GO:0033962)2.11127021
122modulation by symbiont of host cellular process (GO:0044068)2.09943609
123granulocyte activation (GO:0036230)2.08589209
124myeloid cell activation involved in immune response (GO:0002275)2.08291371
125regulation of protein heterodimerization activity (GO:0043497)2.08145148
126B cell receptor signaling pathway (GO:0050853)2.08051139
127cellular defense response (GO:0006968)2.06078919
128positive regulation of calcium-mediated signaling (GO:0050850)2.05917375
129B cell homeostasis (GO:0001782)2.05063157
130regulation of leukocyte mediated cytotoxicity (GO:0001910)2.04039794
131T cell mediated immunity (GO:0002456)2.03642852
132natural killer cell activation (GO:0030101)2.03577838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.75774076
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.69543296
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.88305617
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.38868373
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.25695981
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.14528214
7* RUNX_20019798_ChIP-Seq_JUKART_Human2.56026812
8* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.53884390
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.39098377
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.34939835
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.29583318
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.27337355
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27287627
14MYC_22102868_ChIP-Seq_BL_Human2.26758114
15KDM2B_26808549_Chip-Seq_DND41_Human2.24241808
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.19968395
17TCF7_22412390_ChIP-Seq_EML_Mouse2.13943121
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.10961854
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.09944820
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06936688
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.97578770
22MAF_26560356_Chip-Seq_TH1_Human1.93823812
23* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92874345
24* MYB_26560356_Chip-Seq_TH2_Human1.92412422
25* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90457224
26* KDM2B_26808549_Chip-Seq_JURKAT_Human1.82576789
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79797935
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76688980
29UTX_26944678_Chip-Seq_JUKART_Human1.74713935
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.63916257
31VDR_21846776_ChIP-Seq_THP-1_Human1.63592604
32AR_21572438_ChIP-Seq_LNCaP_Human1.61086960
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60007334
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55564514
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54247178
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53505505
37KDM2B_26808549_Chip-Seq_K562_Human1.52987762
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51354155
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48966819
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.47208351
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46044015
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45701772
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45289034
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44407648
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43548814
46SPI1_23127762_ChIP-Seq_K562_Human1.42443639
47SCL_19346495_ChIP-Seq_HPC-7_Human1.40610975
48* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40222240
49MYB_26560356_Chip-Seq_TH1_Human1.39909587
50* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39391460
51GATA3_27048872_Chip-Seq_THYMUS_Human1.36317348
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35913103
53VDR_24763502_ChIP-Seq_THP-1_Human1.35285976
54VDR_24787735_ChIP-Seq_THP-1_Human1.34251943
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33322169
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31003553
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.30074265
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29589256
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.28904532
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.28295043
61SPI1_23547873_ChIP-Seq_NB4_Human1.27025796
62* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24094523
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.21786275
64* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20312428
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19126188
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18218637
67EZH2_22144423_ChIP-Seq_EOC_Human1.17827682
68* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15895114
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13023513
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11075230
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10982841
72* GATA3_26560356_Chip-Seq_TH2_Human1.10052228
73MAF_26560356_Chip-Seq_TH2_Human1.08998603
74DROSHA_22980978_ChIP-Seq_HELA_Human1.07759088
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05677299
76SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05677299
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03754908
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03380474
79* PU_27001747_Chip-Seq_BMDM_Mouse1.02629686
80* RNF2_27304074_Chip-Seq_ESCs_Mouse1.02447677
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02073043
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01421081
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01223439
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.00416325
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99222106
86RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98657543
87* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98527584
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98472380
89* LXR_22292898_ChIP-Seq_THP-1_Human0.97944140
90BP1_19119308_ChIP-ChIP_Hs578T_Human0.96931912
91* AHR_22903824_ChIP-Seq_MCF-7_Human0.95248073
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94151730
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93449408
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.93153555
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92800843
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92680698
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92519041
98PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91870605
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91126426
100PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90461652
101EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90304327
102RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90304327
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89944606
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88918842
105DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88628620
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87935299
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87738368
108CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86818148
109JARID2_20064375_ChIP-Seq_MESCs_Mouse0.86804309
110* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86622360
111HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86489451
112CJUN_26792858_Chip-Seq_BT549_Human0.86140242
113KLF5_25053715_ChIP-Seq_YYC3_Human0.85622131
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84332082
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.83101798
116CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81956537
117LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81372662
118* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.80053011
119ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79381129
120KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77869291
121KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77869291
122KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77869291
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77119980
124NOTCH1_21737748_ChIP-Seq_TLL_Human0.75589307
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73118276
126SA1_27219007_Chip-Seq_ERYTHROID_Human0.65734173
127* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.64761545
128EZH2_27294783_Chip-Seq_ESCs_Mouse0.63145843
129PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.62696223

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.36294323
2MP0003724_increased_susceptibility_to2.96817911
3MP0003300_gastrointestinal_ulcer2.91259972
4MP0000569_abnormal_digit_pigmentation2.73576275
5MP0003763_abnormal_thymus_physiology2.67539840
6MP0005671_abnormal_response_to2.54741525
7MP0006082_CNS_inflammation2.38683167
8MP0004510_myositis2.31984438
9MP0001835_abnormal_antigen_presentation2.31661102
10MP0000685_abnormal_immune_system2.26303246
11MP0005076_abnormal_cell_differentiation2.25306358
12MP0002166_altered_tumor_susceptibility2.23580378
13MP0003436_decreased_susceptibility_to2.21811976
14MP0005000_abnormal_immune_tolerance2.09188217
15MP0002006_tumorigenesis2.05068633
16MP0010234_abnormal_vibrissa_follicle2.02177084
17MP0001790_abnormal_immune_system2.00234679
18MP0005387_immune_system_phenotype2.00234679
19MP0004947_skin_inflammation1.99689538
20MP0001819_abnormal_immune_cell1.93276787
21MP0002420_abnormal_adaptive_immunity1.91721447
22MP0010352_gastrointestinal_tract_polyps1.91714070
23MP0001800_abnormal_humoral_immune1.90672961
24MP0002452_abnormal_antigen_presenting1.89997411
25MP0003448_altered_tumor_morphology1.88648640
26MP0002723_abnormal_immune_serum1.83305618
27MP0002148_abnormal_hypersensitivity_rea1.81332382
28MP0000858_altered_metastatic_potential1.74022048
29MP0003172_abnormal_lysosome_physiology1.71833701
30MP0003091_abnormal_cell_migration1.69131290
31MP0000703_abnormal_thymus_morphology1.66646965
32MP0004381_abnormal_hair_follicle1.64236473
33MP0003566_abnormal_cell_adhesion1.61566878
34MP0002405_respiratory_system_inflammati1.61155148
35MP0002398_abnormal_bone_marrow1.59794085
36MP0002419_abnormal_innate_immunity1.59390621
37MP0002254_reproductive_system_inflammat1.59171755
38MP0005025_abnormal_response_to1.57371767
39MP0001348_abnormal_lacrimal_gland1.55308894
40MP0003705_abnormal_hypodermis_morpholog1.49585855
41MP0000716_abnormal_immune_system1.48764467
42MP0005464_abnormal_platelet_physiology1.47582679
43MP0004859_abnormal_synaptic_plasticity1.46934279
44MP0003690_abnormal_glial_cell1.41096244
45MP0003045_fibrosis1.37122270
46MP0008961_abnormal_basal_metabolism1.35362776
47MP0002998_abnormal_bone_remodeling1.35296937
48MP0009333_abnormal_splenocyte_physiolog1.34989901
49MP0005623_abnormal_meninges_morphology1.34477769
50MP0001851_eye_inflammation1.34260995
51MP0005310_abnormal_salivary_gland1.30193824
52MP0008260_abnormal_autophagy1.29739951
53MP0002722_abnormal_immune_system1.29543539
54MP0003866_abnormal_defecation1.28630623
55MP0009278_abnormal_bone_marrow1.25827277
56MP0009785_altered_susceptibility_to1.25354280
57MP0005058_abnormal_lysosome_morphology1.24631000
58MP0003329_amyloid_beta_deposits1.24546654
59MP0010155_abnormal_intestine_physiology1.23258210
60MP0002933_joint_inflammation1.21603034
61MP0003453_abnormal_keratinocyte_physiol1.20565988
62MP0001533_abnormal_skeleton_physiology1.19520239
63MP0004808_abnormal_hematopoietic_stem1.18851752
64MP0002009_preneoplasia1.14580200
65MP0000733_abnormal_muscle_development1.12967436
66MP0000689_abnormal_spleen_morphology1.11223278
67MP0005023_abnormal_wound_healing1.10811455
68MP0004858_abnormal_nervous_system1.06974543
69MP0002429_abnormal_blood_cell1.06950353
70MP0001845_abnormal_inflammatory_respons1.03330252
71MP0008469_abnormal_protein_level1.01188940
72MP0003787_abnormal_imprinting0.97996446
73MP0001873_stomach_inflammation0.97193194
74MP0000604_amyloidosis0.91618756
75MP0004130_abnormal_muscle_cell0.91463632
76MP0009764_decreased_sensitivity_to0.90469797
77MP0002877_abnormal_melanocyte_morpholog0.89462053
78MP0001663_abnormal_digestive_system0.88826852
79MP0005174_abnormal_tail_pigmentation0.87976312
80MP0005166_decreased_susceptibility_to0.86642245
81MP0001853_heart_inflammation0.84642676
82MP0002396_abnormal_hematopoietic_system0.83734736
83MP0004142_abnormal_muscle_tone0.82969046
84MP0000920_abnormal_myelination0.82673168
85MP0000537_abnormal_urethra_morphology0.79888733
86MP0010307_abnormal_tumor_latency0.79433383
87MP0003279_aneurysm0.78923378
88MP0005257_abnormal_intraocular_pressure0.78257112
89MP0003635_abnormal_synaptic_transmissio0.77182072
90MP0005075_abnormal_melanosome_morpholog0.75332291
91MP0004185_abnormal_adipocyte_glucose0.75109292
92MP0009053_abnormal_anal_canal0.74781123
93MP0009379_abnormal_foot_pigmentation0.74599267
94MP0005164_abnormal_response_to0.74467115
95MP0000627_abnormal_mammary_gland0.74273156
96MP0001542_abnormal_bone_strength0.73502595
97MP0001299_abnormal_eye_distance/0.72218201
98MP0000465_gastrointestinal_hemorrhage0.72190788
99MP0002277_abnormal_respiratory_mucosa0.71783897
100MP0005275_abnormal_skin_tensile0.70986405
101MP0000778_abnormal_nervous_system0.70950329
102MP0001849_ear_inflammation0.69865242
103MP0001216_abnormal_epidermal_layer0.68796840
104MP0003828_pulmonary_edema0.66599294
105MP0005390_skeleton_phenotype0.66566247
106MP0008569_lethality_at_weaning0.66482197
107MP0002163_abnormal_gland_morphology0.64035739
108MP0000490_abnormal_crypts_of0.62979212
109MP0003075_altered_response_to0.61428195
110MP0005381_digestive/alimentary_phenotyp0.61411511
111MP0002064_seizures0.61359201
112MP0001958_emphysema0.61146319
113MP0002133_abnormal_respiratory_system0.61080041
114MP0005388_respiratory_system_phenotype0.61080041
115MP0004883_abnormal_blood_vessel0.60863694
116MP0004811_abnormal_neuron_physiology0.60334499
117MP0002063_abnormal_learning/memory/cond0.59950254
118MP0003634_abnormal_glial_cell0.59907192
119MP0000767_abnormal_smooth_muscle0.59228994
120MP0003795_abnormal_bone_structure0.59045936
121MP0001545_abnormal_hematopoietic_system0.58357878
122MP0005397_hematopoietic_system_phenotyp0.58357878
123MP0005248_abnormal_Harderian_gland0.54950027
124MP0000249_abnormal_blood_vessel0.53960123
125MP0001440_abnormal_grooming_behavior0.53864120
126MP0000343_altered_response_to0.52782986
127MP0009763_increased_sensitivity_to0.51913065

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)3.37943989
2Abnormality of T cell number (HP:0011839)3.34935665
3Increased IgM level (HP:0003496)3.30670611
4Cerebral aneurysm (HP:0004944)3.23875259
5Arterial tortuosity (HP:0005116)3.23157311
6Recurrent gram-negative bacterial infections (HP:0005420)3.14454456
7Neurofibrillary tangles (HP:0002185)3.07540948
8Autoimmune hemolytic anemia (HP:0001890)2.98389559
9Stomatitis (HP:0010280)2.94533096
10Eczematoid dermatitis (HP:0000976)2.92388257
11Increased cerebral lipofuscin (HP:0011813)2.87381621
12Disinhibition (HP:0000734)2.86752369
13Vascular tortuosity (HP:0004948)2.83383106
14Meningitis (HP:0001287)2.82527106
15Spontaneous hematomas (HP:0007420)2.80901357
16Granulocytopenia (HP:0001913)2.78849545
17Mutism (HP:0002300)2.73989330
18Encephalitis (HP:0002383)2.72325899
19Vasculitis (HP:0002633)2.68180761
20Recurrent abscess formation (HP:0002722)2.63474545
21Increased density of long bones (HP:0006392)2.60053648
22Elevated erythrocyte sedimentation rate (HP:0003565)2.57729263
23Pulmonary infiltrates (HP:0002113)2.54663216
24Recurrent fungal infections (HP:0002841)2.54095312
25Myositis (HP:0100614)2.53562266
26Gastrointestinal infarctions (HP:0005244)2.52327637
27Subacute progressive viral hepatitis (HP:0006572)2.49081010
28IgG deficiency (HP:0004315)2.46005964
29Aortic aneurysm (HP:0004942)2.45722530
30Pustule (HP:0200039)2.44736339
31Shallow orbits (HP:0000586)2.42315706
32Thin bony cortex (HP:0002753)2.41238155
33Recurrent viral infections (HP:0004429)2.40066915
34Abnormality of oral frenula (HP:0000190)2.37983489
35Hypergammaglobulinemia (HP:0010702)2.32957708
36Cerebral inclusion bodies (HP:0100314)2.32359338
37Recurrent skin infections (HP:0001581)2.29336106
38Abnormality of binocular vision (HP:0011514)2.29292476
39Diplopia (HP:0000651)2.29292476
40Nasal polyposis (HP:0100582)2.28667325
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.27812247
42Inappropriate behavior (HP:0000719)2.25786614
43Abnormality of glycolipid metabolism (HP:0010969)2.24551962
44Abnormality of liposaccharide metabolism (HP:0010968)2.24551962
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.24551962
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.24119651
47Frequent falls (HP:0002359)2.23556669
48Dilatation of the ascending aorta (HP:0005111)2.21366852
49Mediastinal lymphadenopathy (HP:0100721)2.21353533
50Obstructive sleep apnea (HP:0002870)2.20654995
51Hematochezia (HP:0002573)2.18342491
52Lymphopenia (HP:0001888)2.16031135
53Absent frontal sinuses (HP:0002688)2.15063690
54Mitral valve prolapse (HP:0001634)2.13925365
55Supernumerary ribs (HP:0005815)2.12781548
56Interstitial pulmonary disease (HP:0006530)2.11765893
57Keratoconjunctivitis sicca (HP:0001097)2.09739583
58Recurrent bronchitis (HP:0002837)2.08689171
59Chest pain (HP:0100749)2.06578565
60Supranuclear gaze palsy (HP:0000605)2.05252300
61Eosinophilia (HP:0001880)2.05108368
62Apathy (HP:0000741)2.04904046
63Thyroiditis (HP:0100646)2.03954436
64Persistence of primary teeth (HP:0006335)2.02691830
65Optic neuritis (HP:0100653)2.00596083
66Retrobulbar optic neuritis (HP:0100654)2.00596083
67Neuronal loss in central nervous system (HP:0002529)1.99813706
68Striae distensae (HP:0001065)1.98429842
69Recurrent bacterial skin infections (HP:0005406)1.98144903
70Aortic dissection (HP:0002647)1.97701712
71Abnormality of T cell physiology (HP:0011840)1.96951069
72IgM deficiency (HP:0002850)1.96932876
73Leukocytosis (HP:0001974)1.96534883
74Chronic otitis media (HP:0000389)1.95963113
75Orchitis (HP:0100796)1.95956572
76Bicuspid aortic valve (HP:0001647)1.95850682
77Hemoptysis (HP:0002105)1.95301980
78Abnormality of eosinophils (HP:0001879)1.94136365
79Diminished motivation (HP:0000745)1.93595600
80Keratoconjunctivitis (HP:0001096)1.92754696
81Hypochromic anemia (HP:0001931)1.91377048
82Obstructive lung disease (HP:0006536)1.88597258
83Chronic obstructive pulmonary disease (HP:0006510)1.88597258
84Autoimmune thrombocytopenia (HP:0001973)1.87837526
85Increased IgE level (HP:0003212)1.86958769
86Genu recurvatum (HP:0002816)1.86957224
87Thick nail (HP:0001805)1.85746117
88Abnormality of T cells (HP:0002843)1.84018291
89Hemiplegia (HP:0002301)1.83985056
90Supernumerary bones of the axial skeleton (HP:0009144)1.82603076
91Abnormality of the nasal mucosa (HP:0000433)1.80067581
92Cellulitis (HP:0100658)1.79443199
93Urticaria (HP:0001025)1.78642939
94Sepsis (HP:0100806)1.78527530
95Disproportionate tall stature (HP:0001519)1.78135145
96Oligodontia (HP:0000677)1.77776181
97Hypoplasia of the thymus (HP:0000778)1.77504785
98Severe combined immunodeficiency (HP:0004430)1.77249068
99Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.76719830
100Hyperacusis (HP:0010780)1.76325995
101Atrophic scars (HP:0001075)1.74345682
102Increased CSF protein (HP:0002922)1.73938379
103Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.73904573
104Macroorchidism (HP:0000053)1.73699030
105Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.73235505
106Dysostosis multiplex (HP:0000943)1.71778040
107Loss of speech (HP:0002371)1.70822933
108Narrow palate (HP:0000189)1.70369440
109Abnormality of the fingertips (HP:0001211)1.69928504
110Abnormal delayed hypersensitivity skin test (HP:0002963)1.69687632
111Slow saccadic eye movements (HP:0000514)1.69486735
112Lower limb amyotrophy (HP:0007210)1.68618550
113Osteolytic defects of the hand bones (HP:0009699)1.68392501
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.68392501
115Recurrent cutaneous fungal infections (HP:0011370)1.68117179
116Chronic mucocutaneous candidiasis (HP:0002728)1.68117179
117Arterial thrombosis (HP:0004420)1.68081443
118Alveolar cell carcinoma (HP:0006519)1.67697158
119Peritonitis (HP:0002586)1.67369719
120Abnormality of the nasal septum (HP:0000419)1.66776332
121Periodontitis (HP:0000704)1.66734342
122Dislocated radial head (HP:0003083)1.66721523
123Pulmonary embolism (HP:0002204)1.65283269
124Verrucae (HP:0200043)1.64688612
125Papilloma (HP:0012740)1.64688612
126Pointed chin (HP:0000307)1.63378346
127Myocardial infarction (HP:0001658)1.63262598
128Panhypogammaglobulinemia (HP:0003139)1.61021808
129Milia (HP:0001056)1.60498438
130Abnormality of macrophages (HP:0004311)1.60420030
131Ankyloglossia (HP:0010296)1.59844420
132Spondylolisthesis (HP:0003302)1.58810391
133Abnormality of the radial head (HP:0003995)1.58533128
134Viral hepatitis (HP:0006562)1.58363880
135Papilledema (HP:0001085)1.58011794
136Aqueductal stenosis (HP:0002410)1.57668700
137Achilles tendon contracture (HP:0001771)1.57622755
138Gingivitis (HP:0000230)1.56148010
139Combined immunodeficiency (HP:0005387)1.56047406
140Exotropia (HP:0000577)1.55976214
141Arnold-Chiari malformation (HP:0002308)1.55963401
142Inflammation of the large intestine (HP:0002037)1.55667357

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK2.71145024
2MAP3K102.70119882
3MAP4K12.62193298
4ITK2.49414983
5PRPF4B2.49342812
6MAP3K92.46252097
7TGFBR22.39293541
8SIK22.08518686
9STK102.07997685
10PKN22.04012527
11SIK31.93670582
12MAP3K131.91055954
13TYK21.87736904
14TRIB31.86916230
15FGFR31.86101233
16TTN1.83279251
17JAK11.82614184
18EEF2K1.82196249
19FGFR41.77200772
20JAK31.73115237
21MARK11.69754652
22GRK61.69399675
23SCYL21.65271716
24MAP3K141.58932070
25RIPK11.58691002
26ZAP701.55018211
27TBK11.42673366
28PTK61.42139284
29IRAK41.39415184
30TAOK31.35312648
31HCK1.34641883
32ALK1.31504087
33NTRK21.31251120
34LRRK21.30054254
35TYRO31.28275386
36EPHB11.26802684
37CSK1.23708565
38IKBKE1.21453758
39LCK1.19398617
40DMPK1.16193261
41PDGFRB1.10638122
42PRKCH1.04056349
43BLK1.03687538
44LYN1.00488607
45CAMK1G0.99141018
46FGFR20.98881824
47CDK60.98063508
48RET0.96614828
49KSR10.95118058
50SIK10.94481486
51PASK0.94388030
52IKBKB0.93853408
53MAP3K30.91649105
54CDK120.91510214
55PAK40.90285845
56PTK20.90166253
57CSF1R0.89080039
58CHUK0.87426154
59TNIK0.87038452
60UHMK10.85546498
61TNK20.84964603
62FES0.84913996
63MAP3K20.83490002
64MOS0.83262749
65BMX0.82851728
66RPS6KA40.82677748
67PDGFRA0.82548241
68MAPK70.81558078
69STK240.81070609
70CAMKK10.79249756
71NTRK10.78875440
72EPHA30.76932238
73JAK20.76260823
74MARK30.74335529
75MAP3K110.74156366
76RIPK40.74013025
77SYK0.73837264
78MAP2K30.72655737
79TAOK10.72346215
80STK110.71564710
81PAK60.71040487
82MST40.70994250
83BMPR20.70871373
84CAMKK20.66878273
85CDC42BPA0.64962017
86FYN0.64492297
87TEC0.62437843
88PIK3CA0.62435341
89CDK190.62431782
90MAP3K10.61886789
91FGFR10.61785761
92SGK20.61034546
93HIPK20.60583512
94SGK4940.58578465
95SGK2230.58578465
96FGR0.58280178
97CAMK1D0.57713949
98GRK70.56209159
99DYRK1B0.56079183
100INSR0.55482043
101KIT0.54832650
102EGFR0.53980851
103PRKCQ0.51637754
104RPS6KA20.50399628
105MAPK120.49593856
106BTK0.49316034
107EPHB20.48888234
108YES10.48807522
109KSR20.47666080
110PAK30.47378075
111MAP3K70.47119707
112CDK40.47010558
113SRC0.46174747
114CASK0.45253541
115MELK0.45186876
116NTRK30.44134082
117PDK10.43669836
118IRAK10.43295809
119CDK50.42725330
120SGK30.41538718
121GSK3A0.41497532
122BRD40.40437442
123ILK0.40286742
124PAK20.40036673
125ROCK20.39997187
126PIM10.39691944
127MARK20.38853291
128MINK10.38698117
129STK380.37045796
130EPHA20.36332956
131NLK0.35785867
132TRPM70.34813093

Predicted pathways (KEGG)

RankGene SetZ-score
1T cell receptor signaling pathway_Homo sapiens_hsa046601.94555022
2Osteoclast differentiation_Homo sapiens_hsa043801.82630434
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.70991205
4Leishmaniasis_Homo sapiens_hsa051401.60545311
5Primary immunodeficiency_Homo sapiens_hsa053401.56255767
6Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46655993
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46597541
8Graft-versus-host disease_Homo sapiens_hsa053321.41714484
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41201241
10Antigen processing and presentation_Homo sapiens_hsa046121.40476235
11Colorectal cancer_Homo sapiens_hsa052101.39515908
12Chronic myeloid leukemia_Homo sapiens_hsa052201.39344909
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36787088
14Viral myocarditis_Homo sapiens_hsa054161.36209292
15Measles_Homo sapiens_hsa051621.36051546
16Toxoplasmosis_Homo sapiens_hsa051451.34176049
17B cell receptor signaling pathway_Homo sapiens_hsa046621.32370233
18Pancreatic cancer_Homo sapiens_hsa052121.30848441
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28485420
20Chemokine signaling pathway_Homo sapiens_hsa040621.24662237
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.23645912
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22628467
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19820740
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.18243512
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17969940
26Allograft rejection_Homo sapiens_hsa053301.17076486
27Endometrial cancer_Homo sapiens_hsa052131.13633186
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.13416222
29TNF signaling pathway_Homo sapiens_hsa046681.11543555
30Renal cell carcinoma_Homo sapiens_hsa052111.09372372
31Apoptosis_Homo sapiens_hsa042101.08874149
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08842178
33Acute myeloid leukemia_Homo sapiens_hsa052211.07414412
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07357612
35Notch signaling pathway_Homo sapiens_hsa043301.05707280
36Proteoglycans in cancer_Homo sapiens_hsa052051.04877220
37Tuberculosis_Homo sapiens_hsa051521.03658461
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.03381558
39Non-small cell lung cancer_Homo sapiens_hsa052231.02812921
40Glioma_Homo sapiens_hsa052141.01658560
41Platelet activation_Homo sapiens_hsa046111.01599700
42Shigellosis_Homo sapiens_hsa051311.00492022
43Hematopoietic cell lineage_Homo sapiens_hsa046401.00021842
44Jak-STAT signaling pathway_Homo sapiens_hsa046300.99506108
45VEGF signaling pathway_Homo sapiens_hsa043700.98909918
46Hepatitis B_Homo sapiens_hsa051610.98459889
47Salmonella infection_Homo sapiens_hsa051320.97404638
48Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95893489
49Asthma_Homo sapiens_hsa053100.94393149
50Adherens junction_Homo sapiens_hsa045200.94010963
51Pertussis_Homo sapiens_hsa051330.93485664
52Type I diabetes mellitus_Homo sapiens_hsa049400.91686706
53mTOR signaling pathway_Homo sapiens_hsa041500.90388659
54Small cell lung cancer_Homo sapiens_hsa052220.90045767
55Estrogen signaling pathway_Homo sapiens_hsa049150.89780251
56Focal adhesion_Homo sapiens_hsa045100.89519724
57Prolactin signaling pathway_Homo sapiens_hsa049170.89259175
58Herpes simplex infection_Homo sapiens_hsa051680.89147857
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88479038
60Endocytosis_Homo sapiens_hsa041440.88431203
61MAPK signaling pathway_Homo sapiens_hsa040100.88389842
62Lysosome_Homo sapiens_hsa041420.88377113
63ErbB signaling pathway_Homo sapiens_hsa040120.85974011
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85493514
65Rap1 signaling pathway_Homo sapiens_hsa040150.84671064
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84625304
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83161382
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82079425
69Axon guidance_Homo sapiens_hsa043600.81690256
70HTLV-I infection_Homo sapiens_hsa051660.80827861
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.80197279
72Ras signaling pathway_Homo sapiens_hsa040140.79346355
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78996778
74MicroRNAs in cancer_Homo sapiens_hsa052060.78949884
75Amoebiasis_Homo sapiens_hsa051460.78322298
76Influenza A_Homo sapiens_hsa051640.77816406
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77488244
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.77378588
79Dorso-ventral axis formation_Homo sapiens_hsa043200.76750100
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.76498602
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75596193
82Long-term potentiation_Homo sapiens_hsa047200.75085994
83Rheumatoid arthritis_Homo sapiens_hsa053230.75000590
84Autoimmune thyroid disease_Homo sapiens_hsa053200.74545951
85Cholinergic synapse_Homo sapiens_hsa047250.74391060
86African trypanosomiasis_Homo sapiens_hsa051430.74270947
87Malaria_Homo sapiens_hsa051440.73601127
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73308974
89Legionellosis_Homo sapiens_hsa051340.72944777
90Oxytocin signaling pathway_Homo sapiens_hsa049210.72268704
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72009918
92Renin secretion_Homo sapiens_hsa049240.71030171
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71007409
94Choline metabolism in cancer_Homo sapiens_hsa052310.71002786
95FoxO signaling pathway_Homo sapiens_hsa040680.70951697
96GnRH signaling pathway_Homo sapiens_hsa049120.70917927
97Synaptic vesicle cycle_Homo sapiens_hsa047210.70749576
98Staphylococcus aureus infection_Homo sapiens_hsa051500.70616399
99Type II diabetes mellitus_Homo sapiens_hsa049300.70256575
100Phagosome_Homo sapiens_hsa041450.69449896
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67219355
102Gastric acid secretion_Homo sapiens_hsa049710.67135720
103Dilated cardiomyopathy_Homo sapiens_hsa054140.66853092
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66286128
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66234351
106Epstein-Barr virus infection_Homo sapiens_hsa051690.66135781
107Prostate cancer_Homo sapiens_hsa052150.64434230
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64210818
109Hepatitis C_Homo sapiens_hsa051600.63748577
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63689506
111Other glycan degradation_Homo sapiens_hsa005110.61994441
112Prion diseases_Homo sapiens_hsa050200.56379136
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54907433
114Pathways in cancer_Homo sapiens_hsa052000.54479979
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53085942
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51242632
117Morphine addiction_Homo sapiens_hsa050320.49341735

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