ARL4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)8.73526550
2cilium or flagellum-dependent cell motility (GO:0001539)8.18009240
3cell wall macromolecule metabolic process (GO:0044036)8.10023078
4cell wall macromolecule catabolic process (GO:0016998)8.10023078
5sperm motility (GO:0030317)7.85785716
6multicellular organism reproduction (GO:0032504)7.62418292
7axonemal dynein complex assembly (GO:0070286)7.45174860
8motile cilium assembly (GO:0044458)7.40080417
9acrosome assembly (GO:0001675)6.90901914
10epithelial cilium movement (GO:0003351)6.74955215
11piRNA metabolic process (GO:0034587)6.66103926
12plasma membrane fusion (GO:0045026)6.65010742
13acrosome reaction (GO:0007340)6.50373504
14sperm-egg recognition (GO:0035036)6.38611041
15reproduction (GO:0000003)6.17080709
16male meiosis (GO:0007140)5.95646829
17cilium movement (GO:0003341)5.94423214
18binding of sperm to zona pellucida (GO:0007339)5.58706539
19cell-cell recognition (GO:0009988)5.45048717
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.40085242
21spermatid development (GO:0007286)5.34967654
22proteasome assembly (GO:0043248)5.30670161
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.27560128
24single fertilization (GO:0007338)4.84825641
25DNA methylation involved in gamete generation (GO:0043046)4.72229866
26energy coupled proton transport, down electrochemical gradient (GO:0015985)4.66828769
27ATP synthesis coupled proton transport (GO:0015986)4.66828769
28lymph vessel development (GO:0001945)4.39767358
29sperm capacitation (GO:0048240)4.15150472
30regulation of cilium movement (GO:0003352)4.13287201
31microtubule depolymerization (GO:0007019)4.04173558
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96486753
33fertilization (GO:0009566)3.95699010
34protein-cofactor linkage (GO:0018065)3.93884326
35synaptonemal complex organization (GO:0070193)3.79847582
36spermatogenesis (GO:0007283)3.78835085
37male gamete generation (GO:0048232)3.76856242
38organic cation transport (GO:0015695)3.74061550
39rRNA modification (GO:0000154)3.74031946
40kinetochore assembly (GO:0051382)3.65410090
41translational termination (GO:0006415)3.63055218
42respiratory electron transport chain (GO:0022904)3.60054209
43viral transcription (GO:0019083)3.59220115
44gamete generation (GO:0007276)3.58406313
45negative regulation of inclusion body assembly (GO:0090084)3.58000416
46ovulation from ovarian follicle (GO:0001542)3.57159642
47electron transport chain (GO:0022900)3.54581153
48ribosomal small subunit assembly (GO:0000028)3.53408821
49kinetochore organization (GO:0051383)3.53269235
50limb bud formation (GO:0060174)3.51762945
51endothelium development (GO:0003158)3.51723240
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.51143186
53NADH dehydrogenase complex assembly (GO:0010257)3.51143186
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51143186
55protein complex biogenesis (GO:0070271)3.49952348
56resolution of meiotic recombination intermediates (GO:0000712)3.45656902
57male meiosis I (GO:0007141)3.45333637
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.43542534
59synaptonemal complex assembly (GO:0007130)3.42423878
60ventricular system development (GO:0021591)3.41816674
61cotranslational protein targeting to membrane (GO:0006613)3.40575764
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40389274
63SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40371244
64positive regulation of respiratory burst (GO:0060267)3.38767393
65mitochondrial respiratory chain complex assembly (GO:0033108)3.38629257
66rRNA methylation (GO:0031167)3.38564114
67nonmotile primary cilium assembly (GO:0035058)3.37148067
68female gonad development (GO:0008585)3.37129011
69synapsis (GO:0007129)3.34427778
70centriole assembly (GO:0098534)3.33893097
71ribosomal large subunit biogenesis (GO:0042273)3.31107237
72monoubiquitinated protein deubiquitination (GO:0035520)3.30155349
73protein targeting to ER (GO:0045047)3.29553692
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24849418
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.22843811
76pyrimidine-containing compound transmembrane transport (GO:0072531)3.22445610
77regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22013648
78regulation of mitotic spindle checkpoint (GO:1903504)3.22013648
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21332303
80inner mitochondrial membrane organization (GO:0007007)3.19649764
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15648692
82protein localization to endoplasmic reticulum (GO:0070972)3.15292725
83cellular process involved in reproduction in multicellular organism (GO:0022412)3.14751080
84protein neddylation (GO:0045116)3.14304460
85establishment of protein localization to endoplasmic reticulum (GO:0072599)3.13995878
86glycerol metabolic process (GO:0006071)3.13952810
87DNA ligation (GO:0006266)3.12403228
88replication fork processing (GO:0031297)3.11786948
89polyol transport (GO:0015791)3.11017790
90establishment of protein localization to mitochondrial membrane (GO:0090151)3.10325301
91gas transport (GO:0015669)3.09633613
92genitalia morphogenesis (GO:0035112)3.08860865
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08569959
94translational elongation (GO:0006414)3.05738379
95oxygen transport (GO:0015671)3.05661793
96germ cell development (GO:0007281)3.05271060
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04728403
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04728403
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04728403
100RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03951581
101tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03951581
102chromatin remodeling at centromere (GO:0031055)3.03363913
103CENP-A containing nucleosome assembly (GO:0034080)3.02820006
104transcytosis (GO:0045056)3.02732122
105tetrapyrrole biosynthetic process (GO:0033014)3.02419190
106protein localization to cilium (GO:0061512)3.01534800
107detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.01474793
108negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01411682
109negative regulation of ligase activity (GO:0051352)3.01411682
110mitotic metaphase plate congression (GO:0007080)3.00798047
111mannosylation (GO:0097502)2.99934977
112signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99297378
113intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99297378
114meiotic cell cycle (GO:0051321)2.97080805
115calcium ion-dependent exocytosis (GO:0017156)2.92319384
116porphyrin-containing compound biosynthetic process (GO:0006779)2.91535830
117multicellular organismal reproductive process (GO:0048609)2.91006502
118protein K6-linked ubiquitination (GO:0085020)2.90974783
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90118883
120histone exchange (GO:0043486)2.89654421
121intraciliary transport (GO:0042073)2.89595942
122regulation of sequestering of triglyceride (GO:0010889)2.88003043
123cellular protein complex disassembly (GO:0043624)2.87539943
124signal transduction involved in DNA damage checkpoint (GO:0072422)2.84433940
125signal transduction involved in DNA integrity checkpoint (GO:0072401)2.84433940
126translational initiation (GO:0006413)2.84085550
127cilium organization (GO:0044782)2.83688853
128seminiferous tubule development (GO:0072520)2.83192034
129signal transduction involved in cell cycle checkpoint (GO:0072395)2.82644423
130positive regulation of ligase activity (GO:0051351)2.79991638
131cilium assembly (GO:0042384)2.79222301
132organelle disassembly (GO:1903008)2.79141740
133metaphase plate congression (GO:0051310)2.78675191
134cell recognition (GO:0008037)2.78062393
135left/right axis specification (GO:0070986)2.77130982
136carnitine transmembrane transport (GO:1902603)2.75887604
137negative regulation of keratinocyte proliferation (GO:0010839)2.75620093
138viral life cycle (GO:0019058)2.74667178
139regulation of cellular amino acid metabolic process (GO:0006521)2.74547244
140regulation of cAMP-dependent protein kinase activity (GO:2000479)2.74382898
141alditol metabolic process (GO:0019400)2.74342777
142protein K11-linked ubiquitination (GO:0070979)2.73965235
143negative regulation of DNA-dependent DNA replication (GO:2000104)2.73500865
144negative regulation of transcription regulatory region DNA binding (GO:2000678)2.71464130
145preassembly of GPI anchor in ER membrane (GO:0016254)2.70805377
146meiotic nuclear division (GO:0007126)2.68332809
147porphyrin-containing compound metabolic process (GO:0006778)2.68052510
148negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.67305236
149protein K11-linked deubiquitination (GO:0035871)2.67181987
150microtubule polymerization or depolymerization (GO:0031109)2.67135127
151ATP biosynthetic process (GO:0006754)2.66742975
152GTP biosynthetic process (GO:0006183)2.65248046
153nucleotide transmembrane transport (GO:1901679)2.64761685
154regulation of meiosis I (GO:0060631)2.63667893
155recombinational repair (GO:0000725)2.63294755
156DNA replication checkpoint (GO:0000076)2.63145773
157meiosis I (GO:0007127)2.62610214
158cullin deneddylation (GO:0010388)2.62140070
159carnitine transport (GO:0015879)2.61796907
160amino-acid betaine transport (GO:0015838)2.61796907
161centriole replication (GO:0007099)2.61063183
162nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.60584980
163double-strand break repair via homologous recombination (GO:0000724)2.59775271
164retina layer formation (GO:0010842)2.59109269
165sphingoid metabolic process (GO:0046519)2.58749042
166response to folic acid (GO:0051593)2.57781787
167DNA double-strand break processing (GO:0000729)2.57611393
168spermatid nucleus differentiation (GO:0007289)2.57458043
169somite development (GO:0061053)2.56963692
170viral protein processing (GO:0019082)2.56735375
171translation (GO:0006412)2.56639625
172regulation of ubiquitin-protein transferase activity (GO:0051438)2.54890504
173keratinocyte development (GO:0003334)2.52930746
174mitotic G2/M transition checkpoint (GO:0044818)2.52573117
175positive regulation of meiotic cell cycle (GO:0051446)2.49641040
176hemidesmosome assembly (GO:0031581)2.49086483
177positive regulation of vasculogenesis (GO:2001214)2.48514025
178quaternary ammonium group transport (GO:0015697)2.48260832
179low-density lipoprotein particle clearance (GO:0034383)2.46007018
180chromosome organization involved in meiosis (GO:0070192)2.45619485
181appendage development (GO:0048736)2.43740730
182limb development (GO:0060173)2.43740730
183positive regulation of odontogenesis (GO:0042482)2.41345282
184regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.40699135
185androgen biosynthetic process (GO:0006702)2.38789834
186regulation of inclusion body assembly (GO:0090083)2.37326733
187one-carbon compound transport (GO:0019755)2.36235286
188* brown fat cell differentiation (GO:0050873)2.34643788
189protoporphyrinogen IX biosynthetic process (GO:0006782)2.32291813
190positive regulation of meiosis (GO:0045836)2.29199899
191multicellular organismal development (GO:0007275)2.28015155
192protoporphyrinogen IX metabolic process (GO:0046501)2.27566492
193cellular component assembly involved in morphogenesis (GO:0010927)2.27132656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.16767856
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.11632517
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.99005965
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.08183442
5ELK1_19687146_ChIP-ChIP_HELA_Human3.04991785
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03056838
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.99919279
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89806621
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.89776061
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.79057194
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72639150
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70983709
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67240497
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.66814751
15* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55190007
16* FOXM1_23109430_ChIP-Seq_U2OS_Human2.51934341
17ZNF274_21170338_ChIP-Seq_K562_Hela2.47500263
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45803076
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.42024058
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36410432
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.35397257
22VDR_23849224_ChIP-Seq_CD4+_Human2.34594905
23EZH2_22144423_ChIP-Seq_EOC_Human2.32817278
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32116758
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.28163305
26GATA1_22025678_ChIP-Seq_K562_Human2.21642263
27* EWS_26573619_Chip-Seq_HEK293_Human2.12750330
28GBX2_23144817_ChIP-Seq_PC3_Human2.09084098
29IGF1R_20145208_ChIP-Seq_DFB_Human2.06988505
30E2F7_22180533_ChIP-Seq_HELA_Human2.05884706
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05151862
32SUZ12_27294783_Chip-Seq_NPCs_Mouse2.04777675
33NFE2_27457419_Chip-Seq_LIVER_Mouse2.01332074
34VDR_22108803_ChIP-Seq_LS180_Human2.00456908
35PCGF2_27294783_Chip-Seq_NPCs_Mouse2.00137234
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96543201
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.93128804
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.83707744
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82167822
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.81594687
41TAF15_26573619_Chip-Seq_HEK293_Human1.81385596
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79906773
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.79052627
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.75829831
45* SRF_21415370_ChIP-Seq_HL-1_Mouse1.75693078
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.75251907
47RNF2_27304074_Chip-Seq_NSC_Mouse1.74963723
48FOXP3_21729870_ChIP-Seq_TREG_Human1.73353435
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72116023
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72016351
51TAL1_26923725_Chip-Seq_HPCs_Mouse1.69614582
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66368303
53P53_22387025_ChIP-Seq_ESCs_Mouse1.66081796
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65958355
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64849375
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62777786
57KAP1_22055183_ChIP-Seq_ESCs_Mouse1.56701430
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.56025321
59* P300_19829295_ChIP-Seq_ESCs_Human1.54144600
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53067914
61SUZ12_18555785_Chip-Seq_ESCs_Mouse1.52982014
62FUS_26573619_Chip-Seq_HEK293_Human1.52943180
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51928170
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.51118739
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.49857892
66KDM2B_26808549_Chip-Seq_REH_Human1.48405384
67STAT3_18555785_Chip-Seq_ESCs_Mouse1.48170977
68MYC_18940864_ChIP-ChIP_HL60_Human1.47090956
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46352097
70EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.45050430
71P300_18555785_Chip-Seq_ESCs_Mouse1.44586513
72OCT4_18555785_Chip-Seq_ESCs_Mouse1.43723015
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.43270311
74* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43236224
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41907947
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41907947
77* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41344493
78NMYC_18555785_Chip-Seq_ESCs_Mouse1.40844399
79TTF2_22483619_ChIP-Seq_HELA_Human1.40279479
80SMAD4_21799915_ChIP-Seq_A2780_Human1.39639590
81SOX2_18555785_Chip-Seq_ESCs_Mouse1.39609821
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.39102772
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38516759
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37399979
85IRF1_19129219_ChIP-ChIP_H3396_Human1.37358181
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.37010324
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36714926
88KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.35853303
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35832440
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34803005
91KLF4_18555785_Chip-Seq_ESCs_Mouse1.34772932
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34329760
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33988338
94ESRRB_18555785_Chip-Seq_ESCs_Mouse1.33726445
95RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32657036
96* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31646246
97* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31334992
98* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31023597
99ZFX_18555785_Chip-Seq_ESCs_Mouse1.29829717
100STAT1_17558387_ChIP-Seq_HELA_Human1.28235247
101AR_25329375_ChIP-Seq_VCAP_Human1.28108841
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27878163
103* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.26857762
104* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.26396178
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25452837
106TP53_22573176_ChIP-Seq_HFKS_Human1.24920875
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24724628
108* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24699305
109PU1_27457419_Chip-Seq_LIVER_Mouse1.24479030
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24026953
111RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23978547
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23870381
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23812264
114* GF1B_26923725_Chip-Seq_HPCs_Mouse1.23510683
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23419725
116MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23247145
117* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22497261
118ELK1_22589737_ChIP-Seq_MCF10A_Human1.21679341
119* SMAD3_21741376_ChIP-Seq_EPCs_Human1.21601912
120PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20885946
121DCP1A_22483619_ChIP-Seq_HELA_Human1.20277827
122* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18731344
123* GF1_26923725_Chip-Seq_HPCs_Mouse1.16712388
124SALL1_21062744_ChIP-ChIP_HESCs_Human1.16061734
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14907046
126ER_23166858_ChIP-Seq_MCF-7_Human1.14022962
127* BCAT_22108803_ChIP-Seq_LS180_Human1.13995958
128SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13574151
129EZH2_27304074_Chip-Seq_ESCs_Mouse1.13451115
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13258049
131CBP_20019798_ChIP-Seq_JUKART_Human1.13258049
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13178449
133SALL4_22934838_ChIP-ChIP_CD34+_Human1.13000995
134CTCF_18555785_Chip-Seq_ESCs_Mouse1.12839752
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12603342
136CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12194079
137SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11598909
138* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10848458
139* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10367080
140EED_16625203_ChIP-ChIP_MESCs_Mouse1.09557405
141* CDX2_22108803_ChIP-Seq_LS180_Human1.08907666
142TCF4_18268006_ChIP-ChIP_LS174T_Human1.08673027
143FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08394472
144MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08258830
145YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07504565
146EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07331983
147MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06995416
148HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06805476
149SOX2_16153702_ChIP-ChIP_HESCs_Human1.05072791
150POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04932816
151RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03580200
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01684466
153* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00611490
154* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00020730
155THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99652629
156ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99416681
157ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99001910
158XRN2_22483619_ChIP-Seq_HELA_Human0.97964586
159NANOG_16153702_ChIP-ChIP_HESCs_Human0.97663484
160FOXA1_25329375_ChIP-Seq_VCAP_Human0.97642813
161FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97642813
162HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96516835
163AR_21909140_ChIP-Seq_LNCAP_Human0.96017738
164* NANOG_19829295_ChIP-Seq_ESCs_Human0.95473155
165* SOX2_19829295_ChIP-Seq_ESCs_Human0.95473155
166FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93858565
167NOTCH1_21737748_ChIP-Seq_TLL_Human0.92079845
168EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91416492
169* AR_20517297_ChIP-Seq_VCAP_Human0.90558863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.39349838
2MP0004147_increased_porphyrin_level3.79254727
3MP0005670_abnormal_white_adipose3.72334001
4MP0002009_preneoplasia3.50627859
5MP0009379_abnormal_foot_pigmentation3.39006511
6MP0000372_irregular_coat_pigmentation2.82952591
7MP0001188_hyperpigmentation2.66318820
8MP0005167_abnormal_blood-brain_barrier2.64987655
9MP0004381_abnormal_hair_follicle2.63345233
10MP0003698_abnormal_male_reproductive2.63280581
11MP0003941_abnormal_skin_development2.58821813
12MP0002736_abnormal_nociception_after2.52482078
13MP0009697_abnormal_copulation2.42991382
14* MP0001929_abnormal_gametogenesis2.40428162
15MP0003186_abnormal_redox_activity2.28801838
16MP0002102_abnormal_ear_morphology2.28487451
17MP0006072_abnormal_retinal_apoptosis2.22988103
18MP0001529_abnormal_vocalization2.20779249
19MP0001879_abnormal_lymphatic_vessel2.20477325
20MP0002938_white_spotting2.20445167
21MP0003724_increased_susceptibility_to2.14329006
22MP0001293_anophthalmia2.04439243
23MP0002234_abnormal_pharynx_morphology2.02622504
24MP0002796_impaired_skin_barrier2.02621592
25MP0003136_yellow_coat_color1.98770693
26MP0008995_early_reproductive_senescence1.94365360
27MP0008877_abnormal_DNA_methylation1.89145476
28MP0003283_abnormal_digestive_organ1.87781599
29MP0002254_reproductive_system_inflammat1.84087968
30MP0005379_endocrine/exocrine_gland_phen1.76413148
31MP0008789_abnormal_olfactory_epithelium1.72220188
32MP0003880_abnormal_central_pattern1.71791778
33MP0010094_abnormal_chromosome_stability1.71027022
34MP0005084_abnormal_gallbladder_morpholo1.68838306
35MP0005408_hypopigmentation1.68555310
36MP0003011_delayed_dark_adaptation1.68294637
37MP0002132_abnormal_respiratory_system1.66887476
38MP0005647_abnormal_sex_gland1.63698977
39MP0004957_abnormal_blastocyst_morpholog1.62574764
40* MP0002210_abnormal_sex_determination1.60900250
41MP0000566_synostosis1.59637138
42MP0003828_pulmonary_edema1.55806763
43MP0008057_abnormal_DNA_replication1.53800694
44MP0001968_abnormal_touch/_nociception1.53568265
45MP0003806_abnormal_nucleotide_metabolis1.53014005
46MP0005666_abnormal_adipose_tissue1.49349996
47MP0010386_abnormal_urinary_bladder1.48226812
48MP0003786_premature_aging1.45786045
49MP0002876_abnormal_thyroid_physiology1.42863296
50MP0010368_abnormal_lymphatic_system1.42248666
51MP0002971_abnormal_brown_adipose1.41732799
52MP0002060_abnormal_skin_morphology1.40003052
53MP0008875_abnormal_xenobiotic_pharmacok1.35007012
54MP0002653_abnormal_ependyma_morphology1.34889246
55MP0000647_abnormal_sebaceous_gland1.34825459
56MP0005275_abnormal_skin_tensile1.34250968
57MP0002161_abnormal_fertility/fecundity1.32268881
58MP0005083_abnormal_biliary_tract1.31384127
59MP0005551_abnormal_eye_electrophysiolog1.30697064
60MP0003693_abnormal_embryo_hatching1.30092454
61MP0003950_abnormal_plasma_membrane1.29939781
62MP0005501_abnormal_skin_physiology1.29423219
63MP0010030_abnormal_orbit_morphology1.29146943
64MP0005646_abnormal_pituitary_gland1.26078480
65MP0003077_abnormal_cell_cycle1.25667312
66* MP0000653_abnormal_sex_gland1.25590224
67MP0004885_abnormal_endolymph1.23838643
68MP0004019_abnormal_vitamin_homeostasis1.23501657
69MP0002098_abnormal_vibrissa_morphology1.22550655
70MP0000569_abnormal_digit_pigmentation1.21046894
71MP0004742_abnormal_vestibular_system1.20804392
72MP0004142_abnormal_muscle_tone1.19084633
73MP0005171_absent_coat_pigmentation1.18962225
74MP0008932_abnormal_embryonic_tissue1.18639344
75* MP0001145_abnormal_male_reproductive1.17956042
76MP0000631_abnormal_neuroendocrine_gland1.17856282
77MP0005391_vision/eye_phenotype1.16567946
78MP0003111_abnormal_nucleus_morphology1.15882406
79MP0000015_abnormal_ear_pigmentation1.13665414
80MP0005334_abnormal_fat_pad1.12761906
81MP0000013_abnormal_adipose_tissue1.12422979
82MP0005409_darkened_coat_color1.11183513
83MP0006276_abnormal_autonomic_nervous1.09302650
84MP0005075_abnormal_melanosome_morpholog1.07617837
85MP0003718_maternal_effect1.06751960
86MP0004272_abnormal_basement_membrane1.03854154
87MP0002751_abnormal_autonomic_nervous1.03222172
88MP0005645_abnormal_hypothalamus_physiol1.02909882
89MP0003878_abnormal_ear_physiology1.02802997
90MP0005377_hearing/vestibular/ear_phenot1.02802997
91MP0002249_abnormal_larynx_morphology1.02303291
92MP0004133_heterotaxia1.00993279
93MP0003890_abnormal_embryonic-extraembry1.00780452
94MP0003787_abnormal_imprinting1.00670940
95MP0002638_abnormal_pupillary_reflex0.99701367
96MP0005174_abnormal_tail_pigmentation0.99377010
97MP0004215_abnormal_myocardial_fiber0.98524856
98MP0001984_abnormal_olfaction0.98281623
99MP0001485_abnormal_pinna_reflex0.98190145
100MP0001286_abnormal_eye_development0.97903124
101MP0005499_abnormal_olfactory_system0.96819885
102MP0005394_taste/olfaction_phenotype0.96819885
103MP0009115_abnormal_fat_cell0.95103516
104MP0001661_extended_life_span0.94713179
105MP0001216_abnormal_epidermal_layer0.93895919
106MP0005535_abnormal_body_temperature0.93120882
107MP0001986_abnormal_taste_sensitivity0.91927410
108MP0000427_abnormal_hair_cycle0.91750095
109MP0010771_integument_phenotype0.91255198
110MP0006292_abnormal_olfactory_placode0.91243788
111MP0001764_abnormal_homeostasis0.90601989
112MP0008872_abnormal_physiological_respon0.90351588
113MP0002277_abnormal_respiratory_mucosa0.89486121
114MP0006036_abnormal_mitochondrial_physio0.88837095
115MP0003119_abnormal_digestive_system0.88744846
116MP0002177_abnormal_outer_ear0.87841952
117MP0005636_abnormal_mineral_homeostasis0.87718393
118MP0003567_abnormal_fetal_cardiomyocyte0.87550112
119MP0002163_abnormal_gland_morphology0.86827227
120MP0006035_abnormal_mitochondrial_morpho0.86501231
121MP0005375_adipose_tissue_phenotype0.86426899
122MP0003315_abnormal_perineum_morphology0.86168167
123MP0006054_spinal_hemorrhage0.85463655
124MP0001324_abnormal_eye_pigmentation0.85268325
125MP0003937_abnormal_limbs/digits/tail_de0.85177606
126MP0003656_abnormal_erythrocyte_physiolo0.83974746
127MP0000749_muscle_degeneration0.83554870
128MP0000383_abnormal_hair_follicle0.83533169
129MP0000762_abnormal_tongue_morphology0.81372769
130MP0004883_abnormal_blood_vessel0.80955184
131MP0005187_abnormal_penis_morphology0.80504771
132MP0000538_abnormal_urinary_bladder0.80319447
133MP0001919_abnormal_reproductive_system0.79808986
134MP0008007_abnormal_cellular_replicative0.79594380
135MP0002139_abnormal_hepatobiliary_system0.79579951
136MP0005253_abnormal_eye_physiology0.79309333
137MP0001486_abnormal_startle_reflex0.77274003
138MP0001664_abnormal_digestion0.76218692
139MP0000467_abnormal_esophagus_morphology0.75618114
140MP0000537_abnormal_urethra_morphology0.75276308
141MP0010678_abnormal_skin_adnexa0.75246610
142MP0001545_abnormal_hematopoietic_system0.73809111
143MP0005397_hematopoietic_system_phenotyp0.73809111
144MP0005503_abnormal_tendon_morphology0.72720136
145MP0000579_abnormal_nail_morphology0.72500053
146MP0005365_abnormal_bile_salt0.71612401
147MP0001119_abnormal_female_reproductive0.70915673
148MP0002282_abnormal_trachea_morphology0.70466668
149MP0005332_abnormal_amino_acid0.70154187
150MP0004130_abnormal_muscle_cell0.70016065
151MP0002693_abnormal_pancreas_physiology0.69994833
152MP0010329_abnormal_lipoprotein_level0.69379234
153MP0000026_abnormal_inner_ear0.68930672
154MP0000613_abnormal_salivary_gland0.68265002
155MP0002697_abnormal_eye_size0.68222768
156MP0005195_abnormal_posterior_eye0.67503114
157MP0003959_abnormal_lean_body0.67419449
158MP0005389_reproductive_system_phenotype0.67392261
159MP0002095_abnormal_skin_pigmentation0.67321308
160MP0001905_abnormal_dopamine_level0.66746851
161MP0002970_abnormal_white_adipose0.66582100
162MP0005220_abnormal_exocrine_pancreas0.65745157
163MP0005448_abnormal_energy_balance0.65530935
164MP0004484_altered_response_of0.64935406
165MP0008058_abnormal_DNA_repair0.64862247

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.76927491
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.54585579
3Absent/shortened dynein arms (HP:0200106)9.54585579
4Abnormal respiratory motile cilium physiology (HP:0012261)6.97461356
5Abnormal respiratory motile cilium morphology (HP:0005938)6.51424075
6Abnormal respiratory epithelium morphology (HP:0012253)6.51424075
7Abnormal ciliary motility (HP:0012262)6.30042041
8Rhinitis (HP:0012384)5.04048218
9Chronic bronchitis (HP:0004469)4.62966083
10Acute necrotizing encephalopathy (HP:0006965)4.00152166
11Infertility (HP:0000789)3.81839896
12Acute encephalopathy (HP:0006846)3.57388026
13Abnormal mitochondria in muscle tissue (HP:0008316)3.57237549
14Progressive macrocephaly (HP:0004481)3.55497247
15Nephronophthisis (HP:0000090)3.52762729
16Mitochondrial inheritance (HP:0001427)3.45631677
17Bronchiectasis (HP:0002110)3.33978859
18Nasal polyposis (HP:0100582)3.17933087
19Abnormal number of erythroid precursors (HP:0012131)3.15654408
20Abnormality of the renal cortex (HP:0011035)3.09872902
21Increased CSF lactate (HP:0002490)3.08816476
22Abnormality of the renal medulla (HP:0100957)3.08557392
23Pancreatic fibrosis (HP:0100732)2.96859649
24Absent eyebrow (HP:0002223)2.94166357
25Hepatocellular necrosis (HP:0001404)2.90869105
26Pancreatic cysts (HP:0001737)2.90774567
27Onycholysis (HP:0001806)2.88702299
28Tubulointerstitial nephritis (HP:0001970)2.87592322
29Type 2 muscle fiber atrophy (HP:0003554)2.83091577
30Abnormality of the nasal mucosa (HP:0000433)2.81794674
31Hepatic necrosis (HP:0002605)2.80669111
32Renal cortical cysts (HP:0000803)2.76052109
33Azoospermia (HP:0000027)2.75142987
34Cerebral edema (HP:0002181)2.71256297
35Abnormality of secondary sexual hair (HP:0009888)2.67834141
36Abnormality of the axillary hair (HP:0100134)2.67834141
37Abnormal spermatogenesis (HP:0008669)2.64444628
38Acanthosis nigricans (HP:0000956)2.58072857
39Macrocytic anemia (HP:0001972)2.57144189
40Insulin-resistant diabetes mellitus (HP:0000831)2.57047000
41Septo-optic dysplasia (HP:0100842)2.56526296
42Increased hepatocellular lipid droplets (HP:0006565)2.55744746
43Amniotic constriction ring (HP:0009775)2.54120681
44Abnormality of placental membranes (HP:0011409)2.54120681
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.52993130
46Congenital, generalized hypertrichosis (HP:0004540)2.51419935
47Stomach cancer (HP:0012126)2.50774545
48Abnormality of the pons (HP:0007361)2.45970274
49Lipid accumulation in hepatocytes (HP:0006561)2.45130860
50Type I transferrin isoform profile (HP:0003642)2.43876026
51Methylmalonic acidemia (HP:0002912)2.40813758
52Absent septum pellucidum (HP:0001331)2.38640842
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.37712914
54Abnormality of the ileum (HP:0001549)2.37580391
55Bronchitis (HP:0012387)2.32953677
56Renal Fanconi syndrome (HP:0001994)2.32328103
57Recurrent sinusitis (HP:0011108)2.31648386
58Hypoplasia of the pons (HP:0012110)2.31211897
59Abnormality of the septum pellucidum (HP:0007375)2.31026399
60Abnormality of midbrain morphology (HP:0002418)2.30855243
61Molar tooth sign on MRI (HP:0002419)2.30855243
62Abnormality of the dental pulp (HP:0006479)2.29589964
63Meckel diverticulum (HP:0002245)2.29514632
64Muscle fiber atrophy (HP:0100295)2.29195639
65Pallor (HP:0000980)2.28974684
66Abnormality of molar morphology (HP:0011070)2.28176460
67Abnormality of molar (HP:0011077)2.28176460
68Duodenal stenosis (HP:0100867)2.26975236
69Small intestinal stenosis (HP:0012848)2.26975236
70Volvulus (HP:0002580)2.25089009
71Tubulointerstitial abnormality (HP:0001969)2.23053877
72Osteomalacia (HP:0002749)2.20198623
73Abnormality of the dental root (HP:0006486)2.18507298
74Taurodontia (HP:0000679)2.18507298
75Abnormality of permanent molar morphology (HP:0011071)2.18507298
76Tubular atrophy (HP:0000092)2.18392543
77Medial flaring of the eyebrow (HP:0010747)2.17997981
78Median cleft lip (HP:0000161)2.17724562
79Absent hand (HP:0004050)2.15040412
80Optic disc pallor (HP:0000543)2.10770935
813-Methylglutaconic aciduria (HP:0003535)2.10519650
82Abnormality of renal resorption (HP:0011038)2.10179647
83Sclerocornea (HP:0000647)2.10160217
84Aplasia/Hypoplasia of the tibia (HP:0005772)2.09106090
85Hypotrichosis (HP:0001006)2.07387999
86Methylmalonic aciduria (HP:0012120)2.06623761
87Nausea (HP:0002018)2.06239590
88Short tibia (HP:0005736)2.05802820
89Abnormality of chromosome stability (HP:0003220)2.05100751
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.02374341
91Bilateral microphthalmos (HP:0007633)2.01788089
92Nephrogenic diabetes insipidus (HP:0009806)2.00158996
93Congenital hepatic fibrosis (HP:0002612)2.00011185
94Abnormality of reticulocytes (HP:0004312)1.99728557
95Prostate neoplasm (HP:0100787)1.99529551
96Renal dysplasia (HP:0000110)1.98904352
97Abnormal protein glycosylation (HP:0012346)1.98524116
98Abnormal glycosylation (HP:0012345)1.98524116
99Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98524116
100Abnormal protein N-linked glycosylation (HP:0012347)1.98524116
101Anencephaly (HP:0002323)1.98287406
102Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96670088
103Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96670088
104Lactic acidosis (HP:0003128)1.96554911
105Gonadotropin excess (HP:0000837)1.96462810
106Increased serum lactate (HP:0002151)1.96158357
107Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95572978
108Abnormality of the duodenum (HP:0002246)1.95169997
109Abnormality of the vitamin B12 metabolism (HP:0004341)1.93574150
110Male infertility (HP:0003251)1.93477152
111Intestinal atresia (HP:0011100)1.93352499
112Amelogenesis imperfecta (HP:0000705)1.93329112
113Hyperglycinemia (HP:0002154)1.92172923
114Abnormality of the preputium (HP:0100587)1.91411018
115Hyperinsulinemic hypoglycemia (HP:0000825)1.91208271
116Absent thumb (HP:0009777)1.91131648
117Decreased central vision (HP:0007663)1.90884002
118Congenital sensorineural hearing impairment (HP:0008527)1.90292831
119Abnormal lung lobation (HP:0002101)1.88852533
120Triphalangeal thumb (HP:0001199)1.88555332
121Exertional dyspnea (HP:0002875)1.87676284
122Abnormality of the renal collecting system (HP:0004742)1.86783696
123Confusion (HP:0001289)1.86614096
124Degeneration of anterior horn cells (HP:0002398)1.85338537
125Abnormality of the anterior horn cell (HP:0006802)1.85338537
126Aplasia cutis congenita (HP:0001057)1.85157788
127Supernumerary spleens (HP:0009799)1.83223387
128Type II lissencephaly (HP:0007260)1.82444637
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.82203489
130Recurrent otitis media (HP:0000403)1.82179938
131Tubulointerstitial fibrosis (HP:0005576)1.81791178
132Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81724953
133Hypochromic microcytic anemia (HP:0004840)1.81600575
134Hypoplasia of dental enamel (HP:0006297)1.79242266
135Stage 5 chronic kidney disease (HP:0003774)1.79080040
136Upper limb muscle weakness (HP:0003484)1.78719667
137Hypodontia (HP:0000668)1.77800223
138Portal hypertension (HP:0001409)1.75426751
139Long foot (HP:0001833)1.75293287
140Parakeratosis (HP:0001036)1.71142845
141Hypertriglyceridemia (HP:0002155)1.70690528
142Thyroid-stimulating hormone excess (HP:0002925)1.70389621
143Symptomatic seizures (HP:0011145)1.68798798
144Reticulocytopenia (HP:0001896)1.68089735
145Ridged nail (HP:0001807)1.67304832
146Abnormality of the hepatic vasculature (HP:0006707)1.66945451
147Dyschromatopsia (HP:0007641)1.65610828
14811 pairs of ribs (HP:0000878)1.64337882
149Hypoglycemic seizures (HP:0002173)1.63705718
150Inability to walk (HP:0002540)1.61223717
151Plantar hyperkeratosis (HP:0007556)1.59564777
152True hermaphroditism (HP:0010459)1.59528959
153Ectropion (HP:0000656)1.57296403
154Optic nerve hypoplasia (HP:0000609)1.56832386
155Alveolar cell carcinoma (HP:0006519)1.56727958
156Nonprogressive disorder (HP:0003680)1.56435446
157Chromsome breakage (HP:0040012)1.55483620
158Duplicated collecting system (HP:0000081)1.55252255
159Gait imbalance (HP:0002141)1.54130274
160Oligomenorrhea (HP:0000876)1.53719774
161Absent hair (HP:0002298)1.53431991
162Thick nail (HP:0001805)1.53418152
163Ileus (HP:0002595)1.52648588
164Abnormal hemoglobin (HP:0011902)1.51531279
165Milia (HP:0001056)1.50524499
166Abnormality of cells of the erythroid lineage (HP:0012130)1.50414756
167Congenital primary aphakia (HP:0007707)1.50075674
168Impulsivity (HP:0100710)1.49645109
169Aplasia/Hypoplasia of the lens (HP:0008063)1.49613665
170Postaxial foot polydactyly (HP:0001830)1.49325462
171Hyperthyroidism (HP:0000836)1.48825651
172Acanthocytosis (HP:0001927)1.48578753
173Metaphyseal irregularity (HP:0003025)1.48318445
174Poikilocytosis (HP:0004447)1.48171680
175Hypothermia (HP:0002045)1.47638368
176Mutism (HP:0002300)1.47465108
177Atelectasis (HP:0100750)1.46735539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK25.11373693
2PDK34.95740720
3PDK44.95740720
4INSRR3.77653398
5TIE13.23948535
6BUB13.13832418
7EIF2AK13.06425887
8TAOK32.97073788
9VRK22.71407316
10WEE12.68025855
11PLK42.61165186
12STK162.54570681
13BRSK22.45178758
14CASK2.43598989
15AKT32.31527356
16NUAK12.23194108
17FRK2.11472627
18MAPK152.08870535
19PLK32.01934618
20PRKD31.97062169
21PLK21.94116551
22MAP4K21.91761480
23CDC71.85562753
24GRK11.82805699
25MUSK1.75001833
26MARK11.70120213
27TNIK1.69940490
28ZAK1.64468477
29MKNK11.64441837
30PTK2B1.58070771
31EIF2AK21.57260116
32MST41.55726669
33EIF2AK31.53788029
34MKNK21.52304276
35NEK11.51970972
36CDK31.51473399
37NEK61.50862785
38IRAK11.42426207
39NME11.41874696
40IRAK31.39534328
41BMPR1B1.38555569
42BMPR21.32847240
43ACVR1B1.30054920
44NLK1.25104092
45BCKDK1.25059148
46ERBB31.21427567
47DYRK21.19374606
48PIM11.12114898
49PBK1.06011337
50MAPK131.05711367
51STK38L1.05388604
52VRK11.04925521
53PLK11.04924616
54TRIM281.03571129
55EPHB21.00839747
56MST1R0.96711319
57PRKAA20.96108134
58DYRK30.95119673
59BRSK10.94091938
60CCNB10.91627754
61PASK0.89735493
62CLK10.89276423
63CDK90.87271969
64CHEK20.85206756
65FER0.85091495
66TGFBR20.84142236
67TGFBR10.82187051
68MAPK70.77585495
69STK40.77160494
70CDK80.76111407
71WNK40.75082830
72TSSK60.74634716
73IRAK20.73343635
74RPS6KA50.71985866
75PNCK0.71775811
76MAP3K40.71142898
77TLK10.70336288
78BCR0.69221251
79NEK20.67036623
80MAP3K140.66369703
81DYRK1B0.66053007
82MAP3K120.65533025
83KSR10.65023008
84MAP2K20.64411303
85MAP3K60.64295138
86TESK10.63568917
87ERBB40.62397173
88PKN10.61172760
89STK30.60703290
90MAP2K70.60283454
91SRPK10.59333293
92DYRK1A0.59271233
93MAP3K30.58942857
94KDR0.57987951
95PRKAA10.57849243
96NTRK20.54750059
97TTK0.54746180
98CHUK0.54022776
99PRKG20.53870070
100GRK50.53127981
101STK390.52665705
102AURKB0.52240684
103STK240.52224517
104ERBB20.51984650
105PRKCE0.51898644
106CSNK2A10.51602883
107BRAF0.51354251
108MAP2K60.50490021
109YES10.49332829
110ATR0.49237812
111GRK60.48965359
112ADRBK20.47989080
113GRK70.47862289
114RAF10.47756611
115BMX0.47662617
116EPHA40.46495452
117TXK0.45028912
118ADRBK10.43005627
119PINK10.42367672
120PRKCZ0.42203332
121PIK3CA0.42104891
122CSNK1G10.41607049
123WNK30.41577381
124MAPKAPK50.39744090
125CSNK2A20.39089871
126PRKG10.38767350
127PIK3CG0.38186170
128CSNK1G20.38174584
129TEC0.38081883
130ATM0.37296904
131IKBKB0.36207047
132GSK3A0.35666664
133MAPK120.35431908
134RPS6KB10.33430212
135CDK60.33172496
136RPS6KA40.32471769
137OXSR10.31974175
138PRKACA0.31612572
139CAMK10.31596504
140CSNK1G30.30814171
141CAMK1D0.30647522
142PIM20.29768615
143IGF1R0.28299805
144ICK0.28127625
145MAPKAPK30.26508511
146MAP2K10.25806368
147OBSCN0.24883133
148PDK10.24318096
149FGFR30.23657679
150FGFR20.23610696

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.86827316
2Propanoate metabolism_Homo sapiens_hsa006403.35703894
3Parkinsons disease_Homo sapiens_hsa050123.25476782
4Fatty acid biosynthesis_Homo sapiens_hsa000613.14964383
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.96928831
6Vitamin digestion and absorption_Homo sapiens_hsa049772.87922446
7Linoleic acid metabolism_Homo sapiens_hsa005912.83780084
8Homologous recombination_Homo sapiens_hsa034402.75392634
9Mismatch repair_Homo sapiens_hsa034302.59946709
10Vitamin B6 metabolism_Homo sapiens_hsa007502.39638694
11PPAR signaling pathway_Homo sapiens_hsa033202.39070396
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32738018
13Basal transcription factors_Homo sapiens_hsa030222.22908450
14Fat digestion and absorption_Homo sapiens_hsa049752.22805312
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.15459519
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07202593
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04113747
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.04059394
19Arachidonic acid metabolism_Homo sapiens_hsa005902.03939908
20Spliceosome_Homo sapiens_hsa030402.02280178
21Fanconi anemia pathway_Homo sapiens_hsa034601.90445276
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.86730745
23Fatty acid elongation_Homo sapiens_hsa000621.81752591
24Nucleotide excision repair_Homo sapiens_hsa034201.80773936
25Fatty acid metabolism_Homo sapiens_hsa012121.76253832
26DNA replication_Homo sapiens_hsa030301.74824805
27Non-homologous end-joining_Homo sapiens_hsa034501.64238352
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60076240
29Ether lipid metabolism_Homo sapiens_hsa005651.58875575
30Glycerolipid metabolism_Homo sapiens_hsa005611.58455181
31RNA transport_Homo sapiens_hsa030131.57556323
32One carbon pool by folate_Homo sapiens_hsa006701.55423016
33Nitrogen metabolism_Homo sapiens_hsa009101.54580359
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54212396
35Ovarian steroidogenesis_Homo sapiens_hsa049131.54067820
36ABC transporters_Homo sapiens_hsa020101.53475643
37Butanoate metabolism_Homo sapiens_hsa006501.46013438
38Sphingolipid metabolism_Homo sapiens_hsa006001.45884341
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.45884001
40Protein digestion and absorption_Homo sapiens_hsa049741.41896893
41Pancreatic secretion_Homo sapiens_hsa049721.34283270
42Cardiac muscle contraction_Homo sapiens_hsa042601.34000547
43Cell cycle_Homo sapiens_hsa041101.31587757
44Fatty acid degradation_Homo sapiens_hsa000711.28502638
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27381899
46Pyruvate metabolism_Homo sapiens_hsa006201.25585273
47Glucagon signaling pathway_Homo sapiens_hsa049221.21807284
48Selenocompound metabolism_Homo sapiens_hsa004501.21551721
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18218051
50Protein export_Homo sapiens_hsa030601.17500297
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17376774
52Huntingtons disease_Homo sapiens_hsa050161.14096526
53beta-Alanine metabolism_Homo sapiens_hsa004101.13971363
54Retinol metabolism_Homo sapiens_hsa008301.11814405
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11619065
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10852354
57Mineral absorption_Homo sapiens_hsa049781.08374120
58Base excision repair_Homo sapiens_hsa034101.08301125
59p53 signaling pathway_Homo sapiens_hsa041151.07868041
60Renin secretion_Homo sapiens_hsa049241.06786796
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05701179
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04870177
63Basal cell carcinoma_Homo sapiens_hsa052171.04071960
64Phototransduction_Homo sapiens_hsa047441.01359779
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.98391201
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.96523085
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95936860
68Ribosome_Homo sapiens_hsa030100.95356543
69Taste transduction_Homo sapiens_hsa047420.95257366
70AMPK signaling pathway_Homo sapiens_hsa041520.93238644
71Steroid biosynthesis_Homo sapiens_hsa001000.91269817
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.88969571
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88169532
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83744473
75Olfactory transduction_Homo sapiens_hsa047400.82913118
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81034132
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.79527211
78Folate biosynthesis_Homo sapiens_hsa007900.78458315
79Regulation of autophagy_Homo sapiens_hsa041400.76975241
80Collecting duct acid secretion_Homo sapiens_hsa049660.76673329
81Purine metabolism_Homo sapiens_hsa002300.76553027
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76236788
83Hematopoietic cell lineage_Homo sapiens_hsa046400.75781395
84Sulfur metabolism_Homo sapiens_hsa009200.75713770
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74686759
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.74395519
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73553188
88Peroxisome_Homo sapiens_hsa041460.72830242
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72221495
90Chemical carcinogenesis_Homo sapiens_hsa052040.69671765
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68382470
92Wnt signaling pathway_Homo sapiens_hsa043100.68209787
93Serotonergic synapse_Homo sapiens_hsa047260.63349779
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62971444
95Autoimmune thyroid disease_Homo sapiens_hsa053200.62227395
96Oocyte meiosis_Homo sapiens_hsa041140.61978724
97Adherens junction_Homo sapiens_hsa045200.60178665
98Axon guidance_Homo sapiens_hsa043600.59870492
99Phenylalanine metabolism_Homo sapiens_hsa003600.59020707
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.58812735
101Glutathione metabolism_Homo sapiens_hsa004800.58077875
102Caffeine metabolism_Homo sapiens_hsa002320.56460820
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56311652
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55634316
105Bile secretion_Homo sapiens_hsa049760.54535541
106Metabolic pathways_Homo sapiens_hsa011000.54087335
107Tyrosine metabolism_Homo sapiens_hsa003500.52896127
108Amphetamine addiction_Homo sapiens_hsa050310.51855410
109Oxidative phosphorylation_Homo sapiens_hsa001900.51109835
110Insulin secretion_Homo sapiens_hsa049110.51016455
111Calcium signaling pathway_Homo sapiens_hsa040200.48345517
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47713798
113Circadian rhythm_Homo sapiens_hsa047100.47080671
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.46807571
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45986713
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43069824
117Histidine metabolism_Homo sapiens_hsa003400.42956233
118RNA polymerase_Homo sapiens_hsa030200.42469884
119Nicotine addiction_Homo sapiens_hsa050330.42035566
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39893761
121TGF-beta signaling pathway_Homo sapiens_hsa043500.39725504
122Tryptophan metabolism_Homo sapiens_hsa003800.39053208
123Prostate cancer_Homo sapiens_hsa052150.38870770
124ECM-receptor interaction_Homo sapiens_hsa045120.38636034
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.38351034
126N-Glycan biosynthesis_Homo sapiens_hsa005100.37397149
127RNA degradation_Homo sapiens_hsa030180.37056615
128Pyrimidine metabolism_Homo sapiens_hsa002400.36951302
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36515271
130Melanogenesis_Homo sapiens_hsa049160.35943601
131mRNA surveillance pathway_Homo sapiens_hsa030150.35571860
132cAMP signaling pathway_Homo sapiens_hsa040240.35477537
133Ras signaling pathway_Homo sapiens_hsa040140.34588116
134Alzheimers disease_Homo sapiens_hsa050100.34543554
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34479946
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.33077965
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31534891
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31518327
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.30657470
140Salivary secretion_Homo sapiens_hsa049700.30013796
141Hedgehog signaling pathway_Homo sapiens_hsa043400.29792147
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28967921
143African trypanosomiasis_Homo sapiens_hsa051430.28956518
144Rheumatoid arthritis_Homo sapiens_hsa053230.24664912
145Epstein-Barr virus infection_Homo sapiens_hsa051690.19965472
146NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19002770

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