ARL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.20363899
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.12580285
3synaptic vesicle maturation (GO:0016188)5.12164805
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.82799432
5synaptic vesicle exocytosis (GO:0016079)4.78948372
6ATP synthesis coupled proton transport (GO:0015986)4.65105587
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.65105587
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.61705533
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.51669942
10regulation of synaptic vesicle exocytosis (GO:2000300)4.42948277
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.40432227
12glutamate secretion (GO:0014047)4.26047077
13positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.24504186
14regulation of synaptic vesicle transport (GO:1902803)4.13974361
15pyrimidine nucleobase catabolic process (GO:0006208)4.10425841
16regulation of synapse structural plasticity (GO:0051823)3.99514869
17sensory perception of smell (GO:0007608)3.93972661
18locomotory exploration behavior (GO:0035641)3.90993857
19respiratory electron transport chain (GO:0022904)3.79702196
20protein complex biogenesis (GO:0070271)3.76651413
21electron transport chain (GO:0022900)3.75303259
22epithelial cilium movement (GO:0003351)3.71746160
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.70089220
24neurotransmitter secretion (GO:0007269)3.67703097
25presynaptic membrane assembly (GO:0097105)3.66377997
26protein neddylation (GO:0045116)3.65540254
27protein localization to synapse (GO:0035418)3.54171370
28activation of protein kinase A activity (GO:0034199)3.50918124
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.46474647
30behavioral response to nicotine (GO:0035095)3.46392884
31neuronal action potential propagation (GO:0019227)3.46326757
32mitochondrial respiratory chain complex assembly (GO:0033108)3.45754602
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.45360462
34NADH dehydrogenase complex assembly (GO:0010257)3.45360462
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.45360462
36presynaptic membrane organization (GO:0097090)3.42763097
37response to pheromone (GO:0019236)3.41991668
38layer formation in cerebral cortex (GO:0021819)3.41176062
39nonmotile primary cilium assembly (GO:0035058)3.39132597
40vocalization behavior (GO:0071625)3.37691404
41regulation of glutamate receptor signaling pathway (GO:1900449)3.36842209
42neuron cell-cell adhesion (GO:0007158)3.35669309
43regulation of cilium movement (GO:0003352)3.33958966
44nucleobase catabolic process (GO:0046113)3.33678845
45protein localization to cilium (GO:0061512)3.33554034
46cell communication by electrical coupling (GO:0010644)3.32115281
47regulation of synaptic transmission, dopaminergic (GO:0032225)3.30622073
48cilium movement (GO:0003341)3.28868186
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.28380469
50sequestering of actin monomers (GO:0042989)3.25326112
51axonemal dynein complex assembly (GO:0070286)3.24724554
52* intraciliary transport (GO:0042073)3.22931156
53protein polyglutamylation (GO:0018095)3.21252738
54striatum development (GO:0021756)3.21037947
55regulation of neuronal synaptic plasticity (GO:0048168)3.19418251
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18470340
57water-soluble vitamin biosynthetic process (GO:0042364)3.13779182
58retinal ganglion cell axon guidance (GO:0031290)3.13598213
59regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.13252218
60regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.13252218
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.09947532
62viral transcription (GO:0019083)3.07813814
63negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06319809
64neurotransmitter transport (GO:0006836)3.05820890
65dopamine receptor signaling pathway (GO:0007212)3.05476072
66adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.04024330
67ribosomal small subunit assembly (GO:0000028)3.02076729
68positive regulation of neurotransmitter transport (GO:0051590)3.01721756
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01579044
70translational termination (GO:0006415)3.01409791
71exploration behavior (GO:0035640)3.00777324
72regulation of neurotransmitter secretion (GO:0046928)2.99748545
73regulation of vesicle fusion (GO:0031338)2.99483357
74regulation of membrane repolarization (GO:0060306)2.99173997
75protein insertion into membrane (GO:0051205)2.98954134
76positive regulation of synapse maturation (GO:0090129)2.96608568
77calcium ion-dependent exocytosis (GO:0017156)2.96524317
78neuromuscular process controlling posture (GO:0050884)2.96215016
79regulation of neurotransmitter transport (GO:0051588)2.93369352
80regulation of long-term neuronal synaptic plasticity (GO:0048169)2.92688661
81cerebellar Purkinje cell layer development (GO:0021680)2.92505819
82cotranslational protein targeting to membrane (GO:0006613)2.92173405
83synaptic vesicle endocytosis (GO:0048488)2.92041554
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91950078
85negative regulation of microtubule polymerization (GO:0031115)2.90526906
86regulation of voltage-gated calcium channel activity (GO:1901385)2.90475487
87regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90072380
88SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.88471474
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87682964
90regulation of rhodopsin mediated signaling pathway (GO:0022400)2.86231862
91rhodopsin mediated signaling pathway (GO:0016056)2.85343713
92protein targeting to ER (GO:0045047)2.85109485
93membrane repolarization (GO:0086009)2.84660813
94cellular potassium ion homeostasis (GO:0030007)2.84386467
95short-term memory (GO:0007614)2.82423950
96regulation of microtubule-based movement (GO:0060632)2.81974894
97postsynaptic membrane organization (GO:0001941)2.81055565
98detection of calcium ion (GO:0005513)2.80833767
99negative regulation of cation channel activity (GO:2001258)2.78169492
100synaptic transmission, glutamatergic (GO:0035249)2.76517015
101neuron-neuron synaptic transmission (GO:0007270)2.76494835
102positive regulation of membrane potential (GO:0045838)2.76458968
103neurotransmitter-gated ion channel clustering (GO:0072578)2.76336648
104regulation of neurotransmitter uptake (GO:0051580)2.76112612
105membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.75251928
106establishment of protein localization to endoplasmic reticulum (GO:0072599)2.75214600
107regulation of neurotransmitter levels (GO:0001505)2.75168889
108ATP biosynthetic process (GO:0006754)2.72861022
109cell migration in hindbrain (GO:0021535)2.72709430
110membrane depolarization during action potential (GO:0086010)2.71865202
111auditory behavior (GO:0031223)2.71331636
112protein localization to endoplasmic reticulum (GO:0070972)2.69767130
113behavioral response to cocaine (GO:0048148)2.69320481
114sensory perception of chemical stimulus (GO:0007606)2.67963629
115regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.67399417
116innervation (GO:0060384)2.66305338
117establishment of synaptic vesicle localization (GO:0097480)2.65954093
118synaptic vesicle transport (GO:0048489)2.65954093
119hydrogen ion transmembrane transport (GO:1902600)2.65604613
120prepulse inhibition (GO:0060134)2.64221995
121sodium ion export (GO:0071436)2.63447006
122regulation of protein kinase A signaling (GO:0010738)2.62711849
123purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.62438098
124positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.61880112
125retinal cone cell development (GO:0046549)2.61678265
126membrane repolarization during action potential (GO:0086011)2.61318963
127neuromuscular synaptic transmission (GO:0007274)2.61278939
128purine nucleoside triphosphate biosynthetic process (GO:0009145)2.61181270
129anterograde axon cargo transport (GO:0008089)2.60888931
130transmission of nerve impulse (GO:0019226)2.59361788
131establishment of vesicle localization (GO:0051650)2.59213066
132potassium ion export (GO:0071435)2.58899452
133melanosome transport (GO:0032402)2.58619092
134positive regulation of potassium ion transmembrane transport (GO:1901381)2.58174124
135regulation of autophagic vacuole assembly (GO:2000785)2.58130079
136anterograde synaptic vesicle transport (GO:0048490)2.57504359
137proline transport (GO:0015824)2.57115124
138cellular response to glucagon stimulus (GO:0071377)2.57114036
139positive regulation of vesicle fusion (GO:0031340)2.57022461
140chaperone-mediated protein transport (GO:0072321)2.56769950
141ATP hydrolysis coupled proton transport (GO:0015991)2.56292340
142energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.56292340
143axonal fasciculation (GO:0007413)2.55728171
144respiratory chain complex IV assembly (GO:0008535)2.55639536
145termination of RNA polymerase III transcription (GO:0006386)2.55313764
146transcription elongation from RNA polymerase III promoter (GO:0006385)2.55313764
147cullin deneddylation (GO:0010388)2.53589661
148neuron recognition (GO:0008038)2.52989106
149translational elongation (GO:0006414)2.52888022
150neuron fate determination (GO:0048664)2.52768756
151protein-cofactor linkage (GO:0018065)2.51340291
152nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51165599
153intracellular protein transmembrane import (GO:0044743)2.50980708
154dendritic spine morphogenesis (GO:0060997)2.50441587
155regulation of mitochondrial translation (GO:0070129)2.49425289
156substrate-independent telencephalic tangential migration (GO:0021826)2.48380535
157substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.48380535
158gamma-aminobutyric acid transport (GO:0015812)2.45657101
159DNA damage response, detection of DNA damage (GO:0042769)2.45635761
160chromatin remodeling at centromere (GO:0031055)2.44844007
161cilium organization (GO:0044782)2.44789405
162exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43143855
163cilium assembly (GO:0042384)2.41962611
164cellular protein complex disassembly (GO:0043624)2.41408520
165limb bud formation (GO:0060174)2.41088608
166proton transport (GO:0015992)2.40189796
167* cilium morphogenesis (GO:0060271)2.38864806
168cytochrome complex assembly (GO:0017004)2.38798384
169positive regulation of gastrulation (GO:2000543)2.38420657
170hydrogen transport (GO:0006818)2.34829320
171viral life cycle (GO:0019058)2.34737749
172organelle disassembly (GO:1903008)2.33207696
173positive regulation of synapse assembly (GO:0051965)2.32212877
174tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.30698666
175RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.30698666
176inner mitochondrial membrane organization (GO:0007007)2.29955381
177ribonucleoside triphosphate biosynthetic process (GO:0009201)2.29573824
178GTP biosynthetic process (GO:0006183)2.29432172
179mechanosensory behavior (GO:0007638)2.29244025
180ribosomal small subunit biogenesis (GO:0042274)2.29124742
181cell proliferation in forebrain (GO:0021846)2.28019226
182platelet dense granule organization (GO:0060155)2.27772297
183aldehyde catabolic process (GO:0046185)2.25401725
184CENP-A containing nucleosome assembly (GO:0034080)2.25235797
185maturation of SSU-rRNA (GO:0030490)2.25113281
186behavioral response to ethanol (GO:0048149)2.24273230
187forebrain neuron differentiation (GO:0021879)2.22560202

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.61846913
2GABP_17652178_ChIP-ChIP_JURKAT_Human2.96833928
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.90283501
4REST_21632747_ChIP-Seq_MESCs_Mouse2.83650564
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.82375440
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76589031
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.62263235
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.58599687
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57252968
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.50178904
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.49186015
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47617323
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47416299
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45749317
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42520749
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34463886
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29251744
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29251744
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.26691584
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.25695923
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22333470
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20580320
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.20548487
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17257214
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14675226
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03884767
27GBX2_23144817_ChIP-Seq_PC3_Human2.03474559
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02553618
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99972435
30FUS_26573619_Chip-Seq_HEK293_Human1.97125204
31DROSHA_22980978_ChIP-Seq_HELA_Human1.94527648
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.93404061
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89488353
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.89098127
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86656912
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85135428
37CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.74133662
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.73605014
39EWS_26573619_Chip-Seq_HEK293_Human1.67952585
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65310754
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62783047
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61325107
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61054269
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61048114
45ELK1_19687146_ChIP-ChIP_HELA_Human1.60267795
46* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59887693
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59150784
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.58045467
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57774604
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56577051
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.50336343
52* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.49286683
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47536893
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47354266
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43244142
56ZNF274_21170338_ChIP-Seq_K562_Hela1.43024946
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39067008
58SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.37063418
59MYC_18940864_ChIP-ChIP_HL60_Human1.36744745
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34483009
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.33570876
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.33240998
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.29965220
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29124137
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25096739
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24563461
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22033084
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20451575
69IGF1R_20145208_ChIP-Seq_DFB_Human1.19562534
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19245631
71OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19173582
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17806009
73* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16834221
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16074130
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15650470
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15265804
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.14303823
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.12609862
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12393013
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12285322
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.11910266
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11102347
83RNF2_27304074_Chip-Seq_NSC_Mouse1.10933070
84TTF2_22483619_ChIP-Seq_HELA_Human1.09798739
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09091667
86IRF1_19129219_ChIP-ChIP_H3396_Human1.08504166
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.08232726
88VDR_22108803_ChIP-Seq_LS180_Human1.07303612
89VDR_23849224_ChIP-Seq_CD4+_Human1.06310631
90MYC_18555785_ChIP-Seq_MESCs_Mouse1.05938752
91TP53_22573176_ChIP-Seq_HFKS_Human1.04333894
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03253480
93* CTCF_27219007_Chip-Seq_Bcells_Human1.03119349
94* SMAD4_21799915_ChIP-Seq_A2780_Human1.02107498
95TET1_21490601_ChIP-Seq_MESCs_Mouse1.02083795
96KDM2B_26808549_Chip-Seq_K562_Human1.01564044
97RING1B_27294783_Chip-Seq_NPCs_Mouse1.01485489
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01328756
99NANOG_16153702_ChIP-ChIP_HESCs_Human1.01244336
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00832338
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99702348
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99290285
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98827242
104RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98528640
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98501836
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97820753
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97820753
108THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96535978
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96523104
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96162042
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95938674
112AR_21572438_ChIP-Seq_LNCaP_Human0.95780440
113AR_25329375_ChIP-Seq_VCAP_Human0.94457863
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94104492
115SMC4_20622854_ChIP-Seq_HELA_Human0.94054561
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93572117
117AR_19668381_ChIP-Seq_PC3_Human0.91941275
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91637564
119TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91558906
120SOX9_26525672_Chip-Seq_HEART_Mouse0.91364219
121RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91193981
122SRF_21415370_ChIP-Seq_HL-1_Mouse0.91048669
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90443308
124CBP_20019798_ChIP-Seq_JUKART_Human0.90443308
125KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89271497
126JUN_21703547_ChIP-Seq_K562_Human0.89268052
127WDR5_24793694_ChIP-Seq_LNCAP_Human0.88967519
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88347185
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87608634
130CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87256405
131NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87245231
132SMAD3_21741376_ChIP-Seq_ESCs_Human0.86819469
133TP53_20018659_ChIP-ChIP_R1E_Mouse0.86665040
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85691888
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85448064
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85417892
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.85019357
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84399682
139CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83977978
140ELK4_26923725_Chip-Seq_MESODERM_Mouse0.82931656
141YY1_22570637_ChIP-Seq_MALME-3M_Human0.81816819
142REST_19997604_ChIP-ChIP_NEURONS_Mouse0.81559063
143KLF4_19829295_ChIP-Seq_ESCs_Human0.81495391
144* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80876149
145P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78101497
146WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77669346
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76937517
148OCT4_19829295_ChIP-Seq_ESCs_Human0.76662391
149P300_19829295_ChIP-Seq_ESCs_Human0.73865071
150TAF15_26573619_Chip-Seq_HEK293_Human0.73727487
151* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.72505029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.35242312
2MP0001984_abnormal_olfaction3.74995182
3MP0006292_abnormal_olfactory_placode3.13381707
4MP0003635_abnormal_synaptic_transmissio2.96351854
5MP0003880_abnormal_central_pattern2.84695438
6MP0004270_analgesia2.71695111
7MP0002653_abnormal_ependyma_morphology2.67828870
8MP0002063_abnormal_learning/memory/cond2.39378452
9MP0003136_yellow_coat_color2.38356519
10MP0009046_muscle_twitch2.36110737
11MP0005423_abnormal_somatic_nervous2.35531303
12MP0005551_abnormal_eye_electrophysiolog2.26410690
13MP0002734_abnormal_mechanical_nocicepti2.21758411
14MP0002064_seizures2.19815187
15MP0009379_abnormal_foot_pigmentation2.19593855
16MP0002822_catalepsy2.17592768
17MP0009745_abnormal_behavioral_response2.16177826
18MP0003646_muscle_fatigue2.11964909
19MP0002938_white_spotting2.07938829
20MP0002572_abnormal_emotion/affect_behav2.01091799
21MP0002909_abnormal_adrenal_gland1.99775410
22MP0003122_maternal_imprinting1.98956155
23MP0004233_abnormal_muscle_weight1.98332021
24MP0002272_abnormal_nervous_system1.96268777
25MP0006072_abnormal_retinal_apoptosis1.91232357
26MP0001968_abnormal_touch/_nociception1.91005969
27MP0003121_genomic_imprinting1.89986784
28MP0004145_abnormal_muscle_electrophysio1.89664858
29MP0002102_abnormal_ear_morphology1.88408824
30MP0002184_abnormal_innervation1.87555423
31MP0004133_heterotaxia1.83360971
32MP0005646_abnormal_pituitary_gland1.81532230
33MP0003011_delayed_dark_adaptation1.80823433
34MP0000751_myopathy1.75521696
35MP0000566_synostosis1.68520005
36MP0002638_abnormal_pupillary_reflex1.66312021
37MP0006276_abnormal_autonomic_nervous1.65150319
38MP0002733_abnormal_thermal_nociception1.64155061
39MP0001293_anophthalmia1.63272609
40MP0001486_abnormal_startle_reflex1.61183972
41MP0005499_abnormal_olfactory_system1.59440903
42MP0005394_taste/olfaction_phenotype1.59440903
43MP0005410_abnormal_fertilization1.59431475
44MP0001970_abnormal_pain_threshold1.58594489
45MP0005645_abnormal_hypothalamus_physiol1.55695811
46MP0002557_abnormal_social/conspecific_i1.54806502
47MP0004811_abnormal_neuron_physiology1.54759604
48MP0005253_abnormal_eye_physiology1.54730462
49MP0002837_dystrophic_cardiac_calcinosis1.54040052
50MP0002736_abnormal_nociception_after1.53683979
51MP0000013_abnormal_adipose_tissue1.49617392
52MP0000778_abnormal_nervous_system1.46636353
53* MP0002882_abnormal_neuron_morphology1.45490930
54MP0008789_abnormal_olfactory_epithelium1.42640030
55MP0002067_abnormal_sensory_capabilities1.42357756
56MP0000049_abnormal_middle_ear1.40870958
57MP0003890_abnormal_embryonic-extraembry1.40681058
58MP0001485_abnormal_pinna_reflex1.40031754
59MP0001529_abnormal_vocalization1.38954161
60MP0001502_abnormal_circadian_rhythm1.35044939
61MP0009780_abnormal_chondrocyte_physiolo1.34846446
62MP0010386_abnormal_urinary_bladder1.34732932
63MP0000955_abnormal_spinal_cord1.34528149
64MP0001501_abnormal_sleep_pattern1.33674272
65MP0008569_lethality_at_weaning1.30681181
66MP0001905_abnormal_dopamine_level1.30468290
67MP0002735_abnormal_chemical_nociception1.28665229
68MP0003879_abnormal_hair_cell1.28163356
69MP0003938_abnormal_ear_development1.27627365
70MP0004858_abnormal_nervous_system1.27523325
71MP0004043_abnormal_pH_regulation1.27079596
72MP0004924_abnormal_behavior1.21949303
73MP0005386_behavior/neurological_phenoty1.21949303
74MP0003787_abnormal_imprinting1.21254079
75MP0001440_abnormal_grooming_behavior1.21220715
76MP0002233_abnormal_nose_morphology1.17248334
77MP0000631_abnormal_neuroendocrine_gland1.17037223
78* MP0002752_abnormal_somatic_nervous1.16593785
79MP0002066_abnormal_motor_capabilities/c1.14710946
80MP0000026_abnormal_inner_ear1.12463984
81MP0004142_abnormal_muscle_tone1.11396630
82MP0010030_abnormal_orbit_morphology1.10881264
83MP0003937_abnormal_limbs/digits/tail_de1.08382325
84MP0002229_neurodegeneration1.07765367
85MP0008877_abnormal_DNA_methylation1.07460446
86MP0002152_abnormal_brain_morphology1.06291691
87MP0001286_abnormal_eye_development1.05560544
88MP0002277_abnormal_respiratory_mucosa1.04890710
89MP0004215_abnormal_myocardial_fiber1.03843375
90MP0003283_abnormal_digestive_organ1.03726755
91MP0000534_abnormal_ureter_morphology1.02560504
92MP0004742_abnormal_vestibular_system1.02409374
93MP0008058_abnormal_DNA_repair1.01943886
94MP0003861_abnormal_nervous_system0.97067266
95MP0001299_abnormal_eye_distance/0.95489651
96MP0003329_amyloid_beta_deposits0.95449121
97MP0003119_abnormal_digestive_system0.95265885
98MP0000749_muscle_degeneration0.94863225
99MP0005391_vision/eye_phenotype0.92390545
100MP0003123_paternal_imprinting0.90945970
101MP0003755_abnormal_palate_morphology0.90606860
102MP0002234_abnormal_pharynx_morphology0.90046170
103MP0005377_hearing/vestibular/ear_phenot0.88937055
104MP0003878_abnormal_ear_physiology0.88937055
105MP0002751_abnormal_autonomic_nervous0.88818274
106MP0002282_abnormal_trachea_morphology0.88256502
107MP0005187_abnormal_penis_morphology0.87473722
108MP0004036_abnormal_muscle_relaxation0.87457704
109MP0001963_abnormal_hearing_physiology0.86513548
110MP0002090_abnormal_vision0.86151524
111MP0002697_abnormal_eye_size0.85445567
112MP0003137_abnormal_impulse_conducting0.84931747
113MP0004085_abnormal_heartbeat0.84411068
114MP0001188_hyperpigmentation0.81917192
115* MP0005195_abnormal_posterior_eye0.81851582
116MP0003698_abnormal_male_reproductive0.81557286
117MP0001986_abnormal_taste_sensitivity0.81125365
118MP0008961_abnormal_basal_metabolism0.79677224
119MP0004885_abnormal_endolymph0.79515959
120MP0002069_abnormal_eating/drinking_beha0.76431940
121MP0005248_abnormal_Harderian_gland0.76401681
122MP0005620_abnormal_muscle_contractility0.75893415
123MP0003634_abnormal_glial_cell0.75787808
124MP0008995_early_reproductive_senescence0.74242726
125MP0002160_abnormal_reproductive_system0.73817858
126* MP0003942_abnormal_urinary_system0.73134912
127MP0003183_abnormal_peptide_metabolism0.72475366
128MP0005623_abnormal_meninges_morphology0.71982657
129MP0001346_abnormal_lacrimal_gland0.71934538
130MP0000647_abnormal_sebaceous_gland0.71500620
131MP0001348_abnormal_lacrimal_gland0.70831319
132MP0002163_abnormal_gland_morphology0.70704306
133MP0005535_abnormal_body_temperature0.70222126
134MP0000678_abnormal_parathyroid_gland0.70135518

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.32642472
2Visual hallucinations (HP:0002367)4.26887286
3Focal motor seizures (HP:0011153)4.05188032
4Abnormality of macular pigmentation (HP:0008002)3.49325360
5Gait imbalance (HP:0002141)3.48359867
6Pheochromocytoma (HP:0002666)3.43628472
7Central scotoma (HP:0000603)3.35429911
8Limb dystonia (HP:0002451)3.34689895
9Congenital primary aphakia (HP:0007707)3.33017505
10Congenital stationary night blindness (HP:0007642)3.31552815
11Septo-optic dysplasia (HP:0100842)3.26611519
12Medial flaring of the eyebrow (HP:0010747)3.20351128
13Neuroendocrine neoplasm (HP:0100634)3.15181131
14Epileptic encephalopathy (HP:0200134)3.10785267
15Bony spicule pigmentary retinopathy (HP:0007737)3.09759955
16Increased hepatocellular lipid droplets (HP:0006565)3.05878554
17Abnormality of the labia minora (HP:0012880)2.97427245
18Focal seizures (HP:0007359)2.97275706
19Nephrogenic diabetes insipidus (HP:0009806)2.97186770
20Pancreatic cysts (HP:0001737)2.92989867
21Increased CSF lactate (HP:0002490)2.88489405
22Abnormal rod and cone electroretinograms (HP:0008323)2.87119907
23Atonic seizures (HP:0010819)2.86664187
24Renal Fanconi syndrome (HP:0001994)2.78921487
25Progressive cerebellar ataxia (HP:0002073)2.70255615
26Lipid accumulation in hepatocytes (HP:0006561)2.67184563
27Absence seizures (HP:0002121)2.61593273
28Hepatocellular necrosis (HP:0001404)2.60264189
29Anxiety (HP:0000739)2.59647811
30Febrile seizures (HP:0002373)2.56448437
31Hyperglycinemia (HP:0002154)2.56161359
32Abnormal mitochondria in muscle tissue (HP:0008316)2.54899207
33Scotoma (HP:0000575)2.53891377
34Acute necrotizing encephalopathy (HP:0006965)2.53429118
35Depression (HP:0000716)2.53130472
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.49018609
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48859812
38Ankle clonus (HP:0011448)2.43910706
39Vaginal atresia (HP:0000148)2.43601269
40Optic nerve hypoplasia (HP:0000609)2.41812701
41Sclerocornea (HP:0000647)2.40664572
42Abnormal respiratory motile cilium physiology (HP:0012261)2.37939096
43Neoplasm of the peripheral nervous system (HP:0100007)2.37278626
44Hepatic necrosis (HP:0002605)2.37138139
45Genital tract atresia (HP:0001827)2.36516337
46Cerebral edema (HP:0002181)2.36436131
47Megalencephaly (HP:0001355)2.35993562
48Methylmalonic acidemia (HP:0002912)2.32279532
49Failure to thrive in infancy (HP:0001531)2.29520206
50Absent septum pellucidum (HP:0001331)2.27213574
51Abnormality of cells of the erythroid lineage (HP:0012130)2.26973947
52Exercise-induced myalgia (HP:0003738)2.25256964
53Torticollis (HP:0000473)2.24325328
54Abnormal number of erythroid precursors (HP:0012131)2.23701500
55Poor coordination (HP:0002370)2.23016223
56Molar tooth sign on MRI (HP:0002419)2.22972850
57Abnormality of midbrain morphology (HP:0002418)2.22972850
58Amblyopia (HP:0000646)2.22924640
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.22867292
60Absent/shortened dynein arms (HP:0200106)2.22867292
61Myotonia (HP:0002486)2.21296281
62Left ventricular hypertrophy (HP:0001712)2.20320556
63Retinal dysplasia (HP:0007973)2.20125654
64Anophthalmia (HP:0000528)2.20048118
65Abnormality of the renal medulla (HP:0100957)2.19665137
66Progressive macrocephaly (HP:0004481)2.18284696
67Dialeptic seizures (HP:0011146)2.17983363
68Anencephaly (HP:0002323)2.17372741
69Generalized tonic-clonic seizures (HP:0002069)2.16820882
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16819337
71Polyphagia (HP:0002591)2.16762249
72Action tremor (HP:0002345)2.14488459
73Reticulocytopenia (HP:0001896)2.13364167
743-Methylglutaconic aciduria (HP:0003535)2.12724237
75Ventricular fibrillation (HP:0001663)2.12715309
76Focal dystonia (HP:0004373)2.11691976
77True hermaphroditism (HP:0010459)2.11658460
78Agitation (HP:0000713)2.10761702
79Aplasia/Hypoplasia of the tongue (HP:0010295)2.10132809
80Specific learning disability (HP:0001328)2.09165407
81Rib fusion (HP:0000902)2.07114081
82Aplasia/Hypoplasia of the lens (HP:0008063)2.06857285
83Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.06803178
84Abnormal ciliary motility (HP:0012262)2.05526145
85Hypercortisolism (HP:0001578)2.05206215
86Rhinitis (HP:0012384)2.04335472
87Acute encephalopathy (HP:0006846)2.02419167
88Craniofacial dystonia (HP:0012179)2.01426276
89Postaxial foot polydactyly (HP:0001830)2.01222408
90Intestinal atresia (HP:0011100)2.00440424
91Colon cancer (HP:0003003)2.00102357
92Macrocytic anemia (HP:0001972)1.98351745
93Chronic bronchitis (HP:0004469)1.97297019
94Maternal diabetes (HP:0009800)1.97247176
95Abnormal respiratory motile cilium morphology (HP:0005938)1.96520874
96Abnormal respiratory epithelium morphology (HP:0012253)1.96520874
97Progressive inability to walk (HP:0002505)1.95905010
98Occipital encephalocele (HP:0002085)1.95736210
99Abnormality of the lower motor neuron (HP:0002366)1.95221174
100Oligodactyly (hands) (HP:0001180)1.95087194
101Type II diabetes mellitus (HP:0005978)1.95024109
102Poor suck (HP:0002033)1.94500509
103Leukodystrophy (HP:0002415)1.92965784
104Supranuclear gaze palsy (HP:0000605)1.92057713
105Pancreatic fibrosis (HP:0100732)1.91044410
106Prolonged QT interval (HP:0001657)1.90185634
107Truncal ataxia (HP:0002078)1.90039581
108Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88625064
109Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88625064
110Abolished electroretinogram (ERG) (HP:0000550)1.88236278
111Bundle branch block (HP:0011710)1.86702276
112Optic disc pallor (HP:0000543)1.86504404
113Bifid tongue (HP:0010297)1.85765604
114Cystic liver disease (HP:0006706)1.85040231
115Preaxial hand polydactyly (HP:0001177)1.84528519
116Abnormality of renal resorption (HP:0011038)1.83962782
117Nephronophthisis (HP:0000090)1.83776192
118Gastrointestinal atresia (HP:0002589)1.82048263
119Broad-based gait (HP:0002136)1.81019750
120Retinitis pigmentosa (HP:0000510)1.80316813
121Abnormal EKG (HP:0003115)1.80271593
122Palpitations (HP:0001962)1.80107171
123Chronic hepatic failure (HP:0100626)1.79717081
124Dyschromatopsia (HP:0007641)1.79679669
125Abnormal eating behavior (HP:0100738)1.79572794
126Abnormality of the septum pellucidum (HP:0007375)1.79271196
127Male pseudohermaphroditism (HP:0000037)1.78765929
128Methylmalonic aciduria (HP:0012120)1.78656173
129Broad foot (HP:0001769)1.77802055
130Mitochondrial inheritance (HP:0001427)1.75453527
131Fetal akinesia sequence (HP:0001989)1.74762765
132Postaxial hand polydactyly (HP:0001162)1.74225221
133Menstrual irregularities (HP:0000858)1.73851257
134Respiratory failure (HP:0002878)1.72437524
135Increased intramyocellular lipid droplets (HP:0012240)1.72142013
136Esophageal atresia (HP:0002032)1.71874913
137Narrow forehead (HP:0000341)1.71307542
138Stenosis of the external auditory canal (HP:0000402)1.71092221
139EEG with generalized epileptiform discharges (HP:0011198)1.70239937
140Abnormality of dentin (HP:0010299)1.70202396
141Hypothermia (HP:0002045)1.70130240
142Neoplasm of the adrenal gland (HP:0100631)1.70053424
143Type II lissencephaly (HP:0007260)1.69350335
144Shoulder girdle muscle weakness (HP:0003547)1.69145477
145Epileptiform EEG discharges (HP:0011182)1.68988764
146Annular pancreas (HP:0001734)1.68437400
147Nuclear cataract (HP:0100018)1.67704654
148Lactic acidosis (HP:0003128)1.67233253
149Supernumerary spleens (HP:0009799)1.67051302
150Decreased testicular size (HP:0008734)1.65975734
151Exertional dyspnea (HP:0002875)1.65845571
152Hemiparesis (HP:0001269)1.65730217
153Severe visual impairment (HP:0001141)1.65606940
154Hypoventilation (HP:0002791)1.64982129
155Adrenal hypoplasia (HP:0000835)1.64872415
156Growth hormone deficiency (HP:0000824)1.64664828
157Lissencephaly (HP:0001339)1.63138748
158Drooling (HP:0002307)1.62950384
159Optic nerve coloboma (HP:0000588)1.61678619
160Congenital, generalized hypertrichosis (HP:0004540)1.61083268
161Hyperphosphaturia (HP:0003109)1.60968893

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD33.58586520
2NTRK33.17797322
3ARAF3.14833158
4MAP3K92.95405229
5STK162.76201241
6PHKG12.69439953
7PHKG22.69439953
8MARK12.46218362
9MINK12.39376146
10EPHA42.32952514
11VRK22.31292339
12MAP3K42.25650111
13MAP2K72.14780717
14KSR22.14032976
15TNIK2.09641745
16PAK61.93523309
17NEK11.91468081
18PDK41.89158898
19PDK31.89158898
20PINK11.82473601
21MAPK151.74073219
22BMPR1B1.73230645
23KSR11.70499962
24VRK11.65361689
25CAMKK11.61256961
26DAPK21.54653771
27CDC71.53611194
28TESK11.52164565
29STK381.50983318
30LATS21.50410799
31BRAF1.48381365
32PLK21.48103287
33MAP3K121.47922232
34BCR1.44724653
35TRIM281.43494136
36MAP4K21.41716929
37SRPK11.41409996
38LMTK21.40596582
39MAP2K41.40473991
40CAMKK21.38348847
41WNK41.37649241
42GRK51.35840184
43NTRK21.35681342
44BUB11.35240492
45ZAK1.34216569
46WEE11.32782307
47PAK31.27469674
48CSNK1G11.26690318
49BCKDK1.25190511
50CSNK1G31.24610431
51MAPK131.23961127
52CASK1.22114848
53FRK1.20873584
54ADRBK21.20855563
55UHMK11.19978568
56DAPK11.19286875
57NUAK11.18642325
58GRK11.17173229
59PRKCG1.14229392
60FGFR21.12831636
61CDK51.10612013
62TRIB31.09254991
63MKNK21.07311430
64DYRK31.06996383
65WNK31.03950226
66CDK141.01594766
67TSSK61.01443064
68CDK181.01161457
69ERBB31.00984270
70CDK190.99979851
71CSNK1A1L0.97304118
72CDK150.97202277
73PLK40.96918156
74NTRK10.96085628
75NME10.92359793
76RAF10.92003566
77SGK2230.88544206
78SGK4940.88544206
79INSRR0.88327471
80MAP3K20.87368197
81CAMK2A0.87018240
82ILK0.86841600
83TLK10.86801818
84CDK11A0.86589567
85PBK0.86575463
86MUSK0.86016343
87OXSR10.82953173
88LIMK10.82589952
89PLK10.80237193
90TAOK10.80151244
91CCNB10.77402914
92STK38L0.77395758
93MKNK10.76644462
94BRSK10.75682172
95MST40.75376163
96PRPF4B0.73515699
97RPS6KA20.71122163
98PDK20.68446718
99PRKCE0.68359085
100CAMK2G0.68211378
101DYRK1A0.67852045
102CAMK2B0.66542894
103PNCK0.65364958
104DAPK30.63991626
105CDC42BPA0.63158857
106TTK0.62936939
107CDK30.62829453
108TAF10.62397871
109CAMK2D0.62250386
110CSNK1E0.59017781
111PTK2B0.58211225
112TYRO30.56811167
113PASK0.55032290
114PRKCZ0.54674353
115EIF2AK30.54186355
116PRKCH0.53240924
117PKN10.53208382
118CSNK1G20.53161210
119CSNK1A10.52864024
120BRSK20.52395789
121SGK20.52361524
122DYRK20.52113496
123EPHB20.51447466
124AURKA0.51131589
125RET0.50656391
126TGFBR10.47793223
127STK110.47115548
128WNK10.46734388
129CDK80.45492147
130SIK30.45283320
131CAMK40.44761655
132CAMK10.44151224
133HIPK20.43745257
134ADRBK10.43639983
135MAP2K10.43416129
136CSNK2A20.42645536
137CHEK20.41733598
138EIF2AK10.40911260
139AURKB0.40106191
140DDR20.40001880
141RPS6KA30.36429406
142MOS0.36221223
143ICK0.35537407
144PRKACA0.34154054
145PLK30.32377532
146MAPKAPK30.32077764
147MAP3K10.30677310
148MAP2K60.30567975
149ALK0.29509434
150SGK30.29477045
151SGK10.29423701

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.87166245
2Synaptic vesicle cycle_Homo sapiens_hsa047213.63988814
3Phototransduction_Homo sapiens_hsa047443.42563633
4Ribosome_Homo sapiens_hsa030103.40331317
5Protein export_Homo sapiens_hsa030603.09634262
6Proteasome_Homo sapiens_hsa030502.49402372
7GABAergic synapse_Homo sapiens_hsa047272.35761891
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.35665155
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35604230
10Circadian entrainment_Homo sapiens_hsa047132.33966214
11Nicotine addiction_Homo sapiens_hsa050332.30810167
12Insulin secretion_Homo sapiens_hsa049112.25476599
13RNA polymerase_Homo sapiens_hsa030202.19614260
14Dopaminergic synapse_Homo sapiens_hsa047282.15470012
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13439348
16Amphetamine addiction_Homo sapiens_hsa050312.11125630
17Parkinsons disease_Homo sapiens_hsa050122.06940081
18Morphine addiction_Homo sapiens_hsa050322.05304029
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04701096
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.01796566
21Oxidative phosphorylation_Homo sapiens_hsa001901.96551307
22Cardiac muscle contraction_Homo sapiens_hsa042601.92710808
23Long-term potentiation_Homo sapiens_hsa047201.86578031
24Glutamatergic synapse_Homo sapiens_hsa047241.84067451
25Cholinergic synapse_Homo sapiens_hsa047251.83548448
26Collecting duct acid secretion_Homo sapiens_hsa049661.81775515
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78065213
28Cocaine addiction_Homo sapiens_hsa050301.71700462
29Vibrio cholerae infection_Homo sapiens_hsa051101.59141308
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58513320
31Butanoate metabolism_Homo sapiens_hsa006501.54174541
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52472233
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52425538
34Huntingtons disease_Homo sapiens_hsa050161.49824287
35Serotonergic synapse_Homo sapiens_hsa047261.47399280
36Steroid biosynthesis_Homo sapiens_hsa001001.45842039
37Alzheimers disease_Homo sapiens_hsa050101.44391274
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43515854
39Taste transduction_Homo sapiens_hsa047421.41816977
40Mismatch repair_Homo sapiens_hsa034301.41466736
41Gastric acid secretion_Homo sapiens_hsa049711.41403432
42Basal transcription factors_Homo sapiens_hsa030221.39562433
43Folate biosynthesis_Homo sapiens_hsa007901.39385797
44Salivary secretion_Homo sapiens_hsa049701.33053316
45Oxytocin signaling pathway_Homo sapiens_hsa049211.32017009
46Propanoate metabolism_Homo sapiens_hsa006401.31620493
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30289195
48Homologous recombination_Homo sapiens_hsa034401.30215995
49Gap junction_Homo sapiens_hsa045401.28592776
50GnRH signaling pathway_Homo sapiens_hsa049121.17438176
51Renin secretion_Homo sapiens_hsa049241.17222525
52Nucleotide excision repair_Homo sapiens_hsa034201.16733915
53Oocyte meiosis_Homo sapiens_hsa041141.16332140
54Basal cell carcinoma_Homo sapiens_hsa052171.13993085
55Fanconi anemia pathway_Homo sapiens_hsa034601.12685793
56RNA degradation_Homo sapiens_hsa030181.12441660
57Calcium signaling pathway_Homo sapiens_hsa040201.09867420
58Glucagon signaling pathway_Homo sapiens_hsa049221.09588685
59Long-term depression_Homo sapiens_hsa047301.08914164
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04227888
61Circadian rhythm_Homo sapiens_hsa047101.03865662
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03440185
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.02730899
64Estrogen signaling pathway_Homo sapiens_hsa049151.01041746
65cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00415587
66Spliceosome_Homo sapiens_hsa030400.99152399
67cAMP signaling pathway_Homo sapiens_hsa040240.97886038
68Melanogenesis_Homo sapiens_hsa049160.94089989
69Dilated cardiomyopathy_Homo sapiens_hsa054140.92288013
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90690778
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89392642
72Pyrimidine metabolism_Homo sapiens_hsa002400.88672543
73Alcoholism_Homo sapiens_hsa050340.87620367
74Glioma_Homo sapiens_hsa052140.86102550
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84203292
76DNA replication_Homo sapiens_hsa030300.83180104
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80705537
78Fatty acid elongation_Homo sapiens_hsa000620.78862378
79Base excision repair_Homo sapiens_hsa034100.77794937
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77642784
81Peroxisome_Homo sapiens_hsa041460.77384668
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76827799
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75342736
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74684470
85beta-Alanine metabolism_Homo sapiens_hsa004100.73708141
86Glutathione metabolism_Homo sapiens_hsa004800.72857736
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71858003
88Metabolic pathways_Homo sapiens_hsa011000.71413973
89RNA transport_Homo sapiens_hsa030130.68825579
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.68580224
91Thyroid hormone synthesis_Homo sapiens_hsa049180.67017326
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65461747
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65438614
94Hippo signaling pathway_Homo sapiens_hsa043900.64801886
95Type II diabetes mellitus_Homo sapiens_hsa049300.64696253
96Insulin signaling pathway_Homo sapiens_hsa049100.64347327
97Type I diabetes mellitus_Homo sapiens_hsa049400.64053291
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.63902256
99Pancreatic secretion_Homo sapiens_hsa049720.62860019
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62805078
101Sulfur relay system_Homo sapiens_hsa041220.62801314
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62426471
103One carbon pool by folate_Homo sapiens_hsa006700.61411849
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61161388
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60592048
106Pyruvate metabolism_Homo sapiens_hsa006200.60345817
107Nitrogen metabolism_Homo sapiens_hsa009100.59728521
108Selenocompound metabolism_Homo sapiens_hsa004500.58524914
109Tryptophan metabolism_Homo sapiens_hsa003800.57424506
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.56400849
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55718196
112Chemical carcinogenesis_Homo sapiens_hsa052040.55654905
113Vitamin B6 metabolism_Homo sapiens_hsa007500.55335628
114Endometrial cancer_Homo sapiens_hsa052130.54730079
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54182478
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53814791
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53771518
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52555635
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52523955
120Axon guidance_Homo sapiens_hsa043600.51198135
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50964313
122mTOR signaling pathway_Homo sapiens_hsa041500.50593473
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.50329277
124Hedgehog signaling pathway_Homo sapiens_hsa043400.50321761
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49960841
126ErbB signaling pathway_Homo sapiens_hsa040120.48964519
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46757605
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46262802
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46113371
130Fructose and mannose metabolism_Homo sapiens_hsa000510.45988503
131Non-homologous end-joining_Homo sapiens_hsa034500.45848860
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45531326
133Linoleic acid metabolism_Homo sapiens_hsa005910.45155945
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44030765
135Biosynthesis of amino acids_Homo sapiens_hsa012300.43256279
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42544603
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42125425
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.40985717
139Carbon metabolism_Homo sapiens_hsa012000.40596894
140Arginine and proline metabolism_Homo sapiens_hsa003300.40563045
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.40377205
142MAPK signaling pathway_Homo sapiens_hsa040100.39958193
143VEGF signaling pathway_Homo sapiens_hsa043700.39482370
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39232943
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39128684
146Dorso-ventral axis formation_Homo sapiens_hsa043200.38911898
147Regulation of autophagy_Homo sapiens_hsa041400.37471445
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37297991
149Renal cell carcinoma_Homo sapiens_hsa052110.37152126
150Ovarian steroidogenesis_Homo sapiens_hsa049130.36789231
151Wnt signaling pathway_Homo sapiens_hsa043100.36466451
152Ras signaling pathway_Homo sapiens_hsa040140.36364444
153Non-small cell lung cancer_Homo sapiens_hsa052230.36105768
154Purine metabolism_Homo sapiens_hsa002300.35565573
155Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34184318
156Retinol metabolism_Homo sapiens_hsa008300.33713378
157Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32921159
158Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32798902
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31254424
160Colorectal cancer_Homo sapiens_hsa052100.30726680

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