ARL17B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.59045545
2DNA double-strand break processing (GO:0000729)3.76897181
3neural tube formation (GO:0001841)3.76511479
4fucose catabolic process (GO:0019317)3.68304953
5L-fucose metabolic process (GO:0042354)3.68304953
6L-fucose catabolic process (GO:0042355)3.68304953
7pyrimidine nucleobase catabolic process (GO:0006208)3.64340762
8DNA deamination (GO:0045006)3.58536301
9replication fork processing (GO:0031297)3.57953633
10protein complex biogenesis (GO:0070271)3.45302578
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44221752
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.44221752
13NADH dehydrogenase complex assembly (GO:0010257)3.44221752
14cornea development in camera-type eye (GO:0061303)3.27657470
15limb bud formation (GO:0060174)3.24158229
16indole-containing compound catabolic process (GO:0042436)3.23935091
17indolalkylamine catabolic process (GO:0046218)3.23935091
18tryptophan catabolic process (GO:0006569)3.23935091
19regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22798059
20regulation of mitotic spindle checkpoint (GO:1903504)3.22798059
21nonmotile primary cilium assembly (GO:0035058)3.22418922
22water-soluble vitamin biosynthetic process (GO:0042364)3.19645756
23response to pheromone (GO:0019236)3.18193806
24regulation of nuclear cell cycle DNA replication (GO:0033262)3.16707302
25indolalkylamine metabolic process (GO:0006586)3.15858247
26detection of light stimulus involved in visual perception (GO:0050908)3.12093771
27detection of light stimulus involved in sensory perception (GO:0050962)3.12093771
28nucleobase catabolic process (GO:0046113)3.11092958
29negative regulation of DNA-dependent DNA replication (GO:2000104)3.10513184
30mitochondrial respiratory chain complex assembly (GO:0033108)3.10372852
31kynurenine metabolic process (GO:0070189)3.09433740
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.08499636
33negative regulation of translation, ncRNA-mediated (GO:0040033)3.08499636
34regulation of translation, ncRNA-mediated (GO:0045974)3.08499636
35gamma-aminobutyric acid transport (GO:0015812)3.05986025
36protein K11-linked deubiquitination (GO:0035871)3.05929990
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05442208
38recombinational repair (GO:0000725)3.03384486
39double-strand break repair via homologous recombination (GO:0000724)3.01477505
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98635054
41somite development (GO:0061053)2.95130021
42negative regulation of telomere maintenance (GO:0032205)2.93550976
43axoneme assembly (GO:0035082)2.90234310
44preassembly of GPI anchor in ER membrane (GO:0016254)2.90066101
45respiratory chain complex IV assembly (GO:0008535)2.89861987
46platelet dense granule organization (GO:0060155)2.89035294
47protein polyglutamylation (GO:0018095)2.88228995
48piRNA metabolic process (GO:0034587)2.87809218
49protein localization to cilium (GO:0061512)2.85007633
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84708840
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84708840
52cilium morphogenesis (GO:0060271)2.83856541
53tryptophan metabolic process (GO:0006568)2.81999927
54presynaptic membrane assembly (GO:0097105)2.81136233
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80822274
56negative regulation of transcription regulatory region DNA binding (GO:2000678)2.79216948
57protein-cofactor linkage (GO:0018065)2.78149044
58epithelial cilium movement (GO:0003351)2.76705213
59maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.76702700
60regulation of telomere maintenance (GO:0032204)2.76037827
61cilium organization (GO:0044782)2.71718920
62cellular biogenic amine catabolic process (GO:0042402)2.70837921
63amine catabolic process (GO:0009310)2.70837921
64regulation of glucokinase activity (GO:0033131)2.70812390
65regulation of hexokinase activity (GO:1903299)2.70812390
66sulfation (GO:0051923)2.69732423
67regulation of meiosis I (GO:0060631)2.69339035
68regulation of DNA endoreduplication (GO:0032875)2.66146564
69cilium assembly (GO:0042384)2.65486931
70centriole replication (GO:0007099)2.64445183
71photoreceptor cell maintenance (GO:0045494)2.64413007
72prenylation (GO:0097354)2.64310320
73protein prenylation (GO:0018342)2.64310320
74photoreceptor cell development (GO:0042461)2.64275119
75intraciliary transport (GO:0042073)2.63005136
76retinal cone cell development (GO:0046549)2.61732355
77sympathetic nervous system development (GO:0048485)2.60666861
78cytochrome complex assembly (GO:0017004)2.60623930
79positive regulation of amino acid transport (GO:0051957)2.59823427
80cellular ketone body metabolic process (GO:0046950)2.59122188
81RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58618497
82somatic hypermutation of immunoglobulin genes (GO:0016446)2.57748636
83somatic diversification of immune receptors via somatic mutation (GO:0002566)2.57748636
84establishment of protein localization to mitochondrial membrane (GO:0090151)2.56183653
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55869250
86DNA methylation involved in gamete generation (GO:0043046)2.55393217
87presynaptic membrane organization (GO:0097090)2.55285695
88regulation of cilium movement (GO:0003352)2.54428917
89synapsis (GO:0007129)2.52365456
90mannosylation (GO:0097502)2.50221593
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49700630
92protein K6-linked ubiquitination (GO:0085020)2.48612935
93kidney morphogenesis (GO:0060993)2.47941382
94neuronal action potential (GO:0019228)2.47722824
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47182873
96GPI anchor metabolic process (GO:0006505)2.46719630
97resolution of meiotic recombination intermediates (GO:0000712)2.45090062
98synaptic transmission, cholinergic (GO:0007271)2.44255586
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43905022
100spinal cord motor neuron differentiation (GO:0021522)2.43424390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.70414346
2GBX2_23144817_ChIP-Seq_PC3_Human3.02299246
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.98619678
4VDR_22108803_ChIP-Seq_LS180_Human2.98301247
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75227433
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.71948728
7IGF1R_20145208_ChIP-Seq_DFB_Human2.69491086
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60637581
9EZH2_22144423_ChIP-Seq_EOC_Human2.59764903
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53458255
11FUS_26573619_Chip-Seq_HEK293_Human2.34652211
12EWS_26573619_Chip-Seq_HEK293_Human2.30647808
13TAF15_26573619_Chip-Seq_HEK293_Human2.26652572
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22342885
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16865773
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16036727
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.15590365
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10464322
19* P300_19829295_ChIP-Seq_ESCs_Human2.10295095
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08989178
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08786508
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02190063
23ER_23166858_ChIP-Seq_MCF-7_Human1.82218684
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73445644
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71949873
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.70644852
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69513257
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69081087
29BCAT_22108803_ChIP-Seq_LS180_Human1.66623302
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.62447593
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59819602
32SMAD4_21799915_ChIP-Seq_A2780_Human1.59238201
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.59110690
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56899680
35STAT3_23295773_ChIP-Seq_U87_Human1.54725134
36CBP_20019798_ChIP-Seq_JUKART_Human1.53987452
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53987452
38MYC_18940864_ChIP-ChIP_HL60_Human1.50696829
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48874858
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48863736
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.44738161
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.44425286
43IRF1_19129219_ChIP-ChIP_H3396_Human1.44343350
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43327851
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43327851
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.42876648
47AR_25329375_ChIP-Seq_VCAP_Human1.41097508
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39702500
49TP53_22573176_ChIP-Seq_HFKS_Human1.39580591
50TCF4_23295773_ChIP-Seq_U87_Human1.38993361
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.38554504
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37169838
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36604068
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36434106
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36010030
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34958732
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.34662367
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33656398
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.32542482
60* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31914863
61RNF2_27304074_Chip-Seq_NSC_Mouse1.30583294
62ELK1_19687146_ChIP-ChIP_HELA_Human1.29772969
63TCF4_22108803_ChIP-Seq_LS180_Human1.29580980
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28441129
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28179865
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27323929
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26652641
68RUNX2_22187159_ChIP-Seq_PCA_Human1.25050584
69* SOX2_19829295_ChIP-Seq_ESCs_Human1.23560135
70* NANOG_19829295_ChIP-Seq_ESCs_Human1.23560135
71REST_21632747_ChIP-Seq_MESCs_Mouse1.22827540
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21869099
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.21392761
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17847327
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17829094
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.13477624
77P53_22387025_ChIP-Seq_ESCs_Mouse1.13416188
78* VDR_23849224_ChIP-Seq_CD4+_Human1.12824650
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.12421132
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12421132
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.11523874
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.11444524
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11139787
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09517097
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09404598
86NCOR_22424771_ChIP-Seq_293T_Human1.06428439
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03833010
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.02775120
89STAT3_18555785_Chip-Seq_ESCs_Mouse1.02432587
90* SMAD4_21741376_ChIP-Seq_EPCs_Human1.02037186
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01523265
92* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00546399
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00512390
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99542472
95AR_21572438_ChIP-Seq_LNCaP_Human0.98524330
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97783294
97SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97767426
98JUN_21703547_ChIP-Seq_K562_Human0.97594520
99* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97441682
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97138109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.28694857
2MP0006292_abnormal_olfactory_placode2.69900509
3MP0003787_abnormal_imprinting2.67332761
4MP0000569_abnormal_digit_pigmentation2.64008582
5MP0003880_abnormal_central_pattern2.47297936
6MP0000372_irregular_coat_pigmentation2.46452533
7MP0005551_abnormal_eye_electrophysiolog2.37523944
8MP0003195_calcinosis2.16695208
9MP0002638_abnormal_pupillary_reflex2.10935261
10MP0001968_abnormal_touch/_nociception2.09128325
11MP0006072_abnormal_retinal_apoptosis2.08338144
12MP0003136_yellow_coat_color1.98517657
13MP0002938_white_spotting1.95747208
14MP0004142_abnormal_muscle_tone1.95151111
15MP0002102_abnormal_ear_morphology1.86905699
16MP0009046_muscle_twitch1.84984978
17MP0002736_abnormal_nociception_after1.83369903
18MP0006276_abnormal_autonomic_nervous1.75819036
19MP0001986_abnormal_taste_sensitivity1.75287217
20MP0001984_abnormal_olfaction1.73951169
21MP0009745_abnormal_behavioral_response1.73540562
22MP0003646_muscle_fatigue1.72851691
23MP0005646_abnormal_pituitary_gland1.71605132
24MP0002837_dystrophic_cardiac_calcinosis1.65661211
25MP0003121_genomic_imprinting1.65004526
26MP0005253_abnormal_eye_physiology1.64856351
27MP0004885_abnormal_endolymph1.63590195
28MP0008058_abnormal_DNA_repair1.63571983
29MP0000631_abnormal_neuroendocrine_gland1.62761620
30MP0001486_abnormal_startle_reflex1.62146794
31MP0002272_abnormal_nervous_system1.55838880
32MP0005645_abnormal_hypothalamus_physiol1.52303578
33MP0005423_abnormal_somatic_nervous1.48930779
34MP0008057_abnormal_DNA_replication1.48896122
35MP0000427_abnormal_hair_cycle1.44382646
36MP0004133_heterotaxia1.42587161
37MP0008872_abnormal_physiological_respon1.41116001
38MP0002163_abnormal_gland_morphology1.40809616
39MP0005174_abnormal_tail_pigmentation1.40467386
40MP0002735_abnormal_chemical_nociception1.39992758
41MP0003122_maternal_imprinting1.36809011
42MP0002653_abnormal_ependyma_morphology1.36553935
43MP0001529_abnormal_vocalization1.34598849
44MP0010386_abnormal_urinary_bladder1.29839404
45MP0001501_abnormal_sleep_pattern1.29018207
46MP0005075_abnormal_melanosome_morpholog1.28863306
47MP0008995_early_reproductive_senescence1.28708053
48MP0008789_abnormal_olfactory_epithelium1.28580875
49MP0002876_abnormal_thyroid_physiology1.26491881
50MP0002234_abnormal_pharynx_morphology1.26174089
51MP0004145_abnormal_muscle_electrophysio1.24881927
52MP0005386_behavior/neurological_phenoty1.24574164
53MP0004924_abnormal_behavior1.24574164
54MP0008875_abnormal_xenobiotic_pharmacok1.24108883
55MP0001485_abnormal_pinna_reflex1.21539007
56MP0002572_abnormal_emotion/affect_behav1.19996429
57MP0005084_abnormal_gallbladder_morpholo1.19981952
58MP0003011_delayed_dark_adaptation1.17930269
59MP0002064_seizures1.16568010
60MP0005379_endocrine/exocrine_gland_phen1.13738632
61MP0000778_abnormal_nervous_system1.11857573
62MP0002557_abnormal_social/conspecific_i1.11417586
63MP0002095_abnormal_skin_pigmentation1.09736020
64MP0001970_abnormal_pain_threshold1.08863678
65MP0003635_abnormal_synaptic_transmissio1.08597858
66MP0004742_abnormal_vestibular_system1.08537039
67MP0004043_abnormal_pH_regulation1.07586017
68MP0004147_increased_porphyrin_level1.06912242
69MP0003718_maternal_effect1.06698568
70MP0002751_abnormal_autonomic_nervous1.06669912
71MP0002067_abnormal_sensory_capabilities1.04433383
72MP0005389_reproductive_system_phenotype1.03666172
73MP0002733_abnormal_thermal_nociception1.00042528
74MP0005195_abnormal_posterior_eye0.99356004
75MP0001324_abnormal_eye_pigmentation0.98425923
76MP0002063_abnormal_learning/memory/cond0.96654650
77MP0002160_abnormal_reproductive_system0.96346270
78MP0002928_abnormal_bile_duct0.94132473
79MP0002752_abnormal_somatic_nervous0.93696969
80MP0005171_absent_coat_pigmentation0.93510577
81MP0003698_abnormal_male_reproductive0.93369478
82MP0000383_abnormal_hair_follicle0.92316723
83MP0002734_abnormal_mechanical_nocicepti0.89410607
84MP0005499_abnormal_olfactory_system0.88654108
85MP0005394_taste/olfaction_phenotype0.88654108
86MP0003786_premature_aging0.88506739
87MP0010094_abnormal_chromosome_stability0.88444619
88MP0001929_abnormal_gametogenesis0.87191704
89MP0001919_abnormal_reproductive_system0.86410401
90MP0001293_anophthalmia0.83524389
91MP0001905_abnormal_dopamine_level0.83003484
92MP0000647_abnormal_sebaceous_gland0.82815125
93MP0003567_abnormal_fetal_cardiomyocyte0.82604572
94MP0001764_abnormal_homeostasis0.82516966
95MP0004215_abnormal_myocardial_fiber0.82414150
96MP0003937_abnormal_limbs/digits/tail_de0.82407013
97MP0002210_abnormal_sex_determination0.81890875
98MP0000026_abnormal_inner_ear0.80115292
99MP0003890_abnormal_embryonic-extraembry0.79294380
100MP0000653_abnormal_sex_gland0.78813418

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.28813144
2True hermaphroditism (HP:0010459)4.19184801
3Pancreatic fibrosis (HP:0100732)3.97537254
4Abnormality of midbrain morphology (HP:0002418)3.87858987
5Molar tooth sign on MRI (HP:0002419)3.87858987
6Nephronophthisis (HP:0000090)3.69569748
7Congenital stationary night blindness (HP:0007642)3.59226882
8Medial flaring of the eyebrow (HP:0010747)3.32215724
9Hyperventilation (HP:0002883)3.27836501
10Abnormality of the renal medulla (HP:0100957)3.20827536
11Abnormality of the renal cortex (HP:0011035)3.07286843
12Abnormality of the labia minora (HP:0012880)3.01155104
13Type II lissencephaly (HP:0007260)2.89130763
14Gait imbalance (HP:0002141)2.82261824
15Congenital primary aphakia (HP:0007707)2.72374326
16Cystic liver disease (HP:0006706)2.60252128
17Abnormal rod and cone electroretinograms (HP:0008323)2.57849314
18Gaze-evoked nystagmus (HP:0000640)2.56976761
19Attenuation of retinal blood vessels (HP:0007843)2.52311054
20Nephrogenic diabetes insipidus (HP:0009806)2.48414703
21Pendular nystagmus (HP:0012043)2.46605630
22Renal cortical cysts (HP:0000803)2.45935365
23Chronic hepatic failure (HP:0100626)2.43879929
24Broad-based gait (HP:0002136)2.43464618
25Sclerocornea (HP:0000647)2.40875548
26Febrile seizures (HP:0002373)2.38211186
27Genital tract atresia (HP:0001827)2.35781020
28Aplasia/Hypoplasia of the tongue (HP:0010295)2.34887310
29Volvulus (HP:0002580)2.32928252
30Vaginal atresia (HP:0000148)2.30918483
31Abolished electroretinogram (ERG) (HP:0000550)2.28324578
32Progressive cerebellar ataxia (HP:0002073)2.23423936
33Anencephaly (HP:0002323)2.23009532
34Male pseudohermaphroditism (HP:0000037)2.17884909
35Genetic anticipation (HP:0003743)2.16943354
36Atonic seizures (HP:0010819)2.13893949
37Increased CSF lactate (HP:0002490)2.13747354
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.10629300
39Methylmalonic acidemia (HP:0002912)2.09935853
40Hypothermia (HP:0002045)2.09749727
41Stomach cancer (HP:0012126)2.09186481
42Congenital hepatic fibrosis (HP:0002612)2.08349080
43Lissencephaly (HP:0001339)2.07915659
44Inability to walk (HP:0002540)2.06946180
45Focal motor seizures (HP:0011153)2.06568071
46Mitochondrial inheritance (HP:0001427)2.06262652
47Optic nerve hypoplasia (HP:0000609)2.05493633
48Abnormal drinking behavior (HP:0030082)2.04750297
49Polydipsia (HP:0001959)2.04750297
50Tubular atrophy (HP:0000092)2.04420553
51Protruding tongue (HP:0010808)2.03567659
52Postaxial foot polydactyly (HP:0001830)2.02475158
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02285970
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.01232168
55Thyroiditis (HP:0100646)2.00843324
56Postaxial hand polydactyly (HP:0001162)1.99737388
57Acute necrotizing encephalopathy (HP:0006965)1.98764897
58Poor coordination (HP:0002370)1.98387564
59Furrowed tongue (HP:0000221)1.97063677
60Dialeptic seizures (HP:0011146)1.96226651
61Pachygyria (HP:0001302)1.95486395
62Hepatocellular necrosis (HP:0001404)1.93476558
63Aplasia/Hypoplasia of the fovea (HP:0008060)1.93402458
64Hypoplasia of the fovea (HP:0007750)1.93402458
65Progressive macrocephaly (HP:0004481)1.92403830
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92161737
67Abnormality of the ileum (HP:0001549)1.91214144
68Absent speech (HP:0001344)1.89640760
69Meckel diverticulum (HP:0002245)1.89581604
70Astigmatism (HP:0000483)1.88725488
71Progressive inability to walk (HP:0002505)1.87584976
72Patellar aplasia (HP:0006443)1.87223333
73Focal seizures (HP:0007359)1.86971526
74Increased corneal curvature (HP:0100692)1.86367484
75Keratoconus (HP:0000563)1.86367484
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84568193
77Dyskinesia (HP:0100660)1.84250171
78Preaxial hand polydactyly (HP:0001177)1.83129559
79Decreased central vision (HP:0007663)1.82109266
80Abnormality of alanine metabolism (HP:0010916)1.81615195
81Hyperalaninemia (HP:0003348)1.81615195
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81615195
83Acute encephalopathy (HP:0006846)1.81606024
84Hyperglycinemia (HP:0002154)1.80205378
85Abnormality of chromosome stability (HP:0003220)1.79965915
86Oligodactyly (hands) (HP:0001180)1.79785860
87Ectopic kidney (HP:0000086)1.79781041
88Small hand (HP:0200055)1.79009334
89Retinal dysplasia (HP:0007973)1.77874337
90Hepatic necrosis (HP:0002605)1.77239081
91Intestinal atresia (HP:0011100)1.77082988
92Aplasia/Hypoplasia of the patella (HP:0006498)1.76801793
93Sloping forehead (HP:0000340)1.75987371
94Clubbing of toes (HP:0100760)1.75458585
95Colon cancer (HP:0003003)1.74886085
96Dandy-Walker malformation (HP:0001305)1.74561345
97Abnormality of macular pigmentation (HP:0008002)1.74168243
98Optic disc pallor (HP:0000543)1.73921938
99Hemiparesis (HP:0001269)1.73267743
100Aganglionic megacolon (HP:0002251)1.72832918

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.52931621
2CASK3.03963569
3BMPR1B2.82700673
4WNK32.77582059
5MAP4K22.66310909
6PINK12.40840987
7NUAK12.38396420
8ZAK2.33458550
9ADRBK22.19392503
10MAPK132.14366690
11ACVR1B2.13880839
12TNIK2.11551356
13TAOK31.98590378
14GRK11.98426011
15MKNK21.87571563
16MAP3K41.75979406
17MARK11.74856509
18INSRR1.66578146
19TRIM281.48934408
20WNK41.44672579
21TLK11.42058801
22FGFR21.37199038
23PNCK1.36535718
24DYRK21.36431365
25PAK31.29737890
26ERBB31.22212927
27OXSR11.21114366
28PLK21.20482306
29MAP2K71.16897082
30STK391.16401873
31MKNK11.14232900
32TXK1.06442425
33BRSK21.03887348
34PLK41.03354694
35VRK11.00659644
36EPHA41.00609986
37PRKCE0.88449997
38PLK30.86772463
39STK38L0.86064411
40WEE10.85788973
41ADRBK10.84796966
42PRKCG0.84765829
43AKT30.84418949
44CSNK1G10.82349743
45BCKDK0.82220674
46TGFBR10.81520885
47CSNK1G20.80311789
48PKN10.76149367
49TEC0.75425908
50NTRK30.71763582
51BCR0.68643263
52CSNK1G30.67590876
53NTRK20.67493674
54MARK30.67316627
55CAMKK20.67029477
56EIF2AK30.64651416
57CAMK1G0.63149061
58PIK3CA0.61963508
59CAMK10.61156386
60CSNK1A1L0.60754748
61DYRK30.58331057
62OBSCN0.58148229
63PHKG20.55337293
64PHKG10.55337293
65DAPK20.55259116
66PRKCQ0.54795487
67PLK10.54712806
68IRAK10.52906358
69CSNK1A10.52078148
70MUSK0.51926310
71SGK20.51684265
72CAMK2A0.51554733
73ATR0.51123195
74MST40.50534066
75ATM0.49985795
76NLK0.49657429
77CAMK1D0.48694276
78PRKACA0.47530682
79CCNB10.44274018
80CDC70.43099563
81CDK190.42925015
82CDK30.42468061
83IKBKB0.42083562
84PTK2B0.41512064
85STK30.39658541
86PRKG10.39413048
87RPS6KA50.37912481
88FLT30.37908859
89DYRK1A0.37745920
90CHEK20.37723836
91CSNK1D0.37347302
92BUB10.36679032
93MAP2K60.36596447
94TNK20.36555929
95PRKAA10.35164618
96SRPK10.34955109
97CAMK40.33148706
98STK110.31982962
99PRKCZ0.31954996
100MINK10.31638294

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.82851750
2Homologous recombination_Homo sapiens_hsa034402.64999169
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.62523434
4Protein export_Homo sapiens_hsa030602.47376210
5Fanconi anemia pathway_Homo sapiens_hsa034602.46253097
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.44529626
7Nicotine addiction_Homo sapiens_hsa050332.26633903
8Oxidative phosphorylation_Homo sapiens_hsa001902.23286161
9RNA polymerase_Homo sapiens_hsa030202.20008677
10Propanoate metabolism_Homo sapiens_hsa006402.07925317
11Butanoate metabolism_Homo sapiens_hsa006502.07176952
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05025693
13Non-homologous end-joining_Homo sapiens_hsa034502.04683608
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.02003141
15Linoleic acid metabolism_Homo sapiens_hsa005911.96496928
16Basal transcription factors_Homo sapiens_hsa030221.96165733
17Nitrogen metabolism_Homo sapiens_hsa009101.95196803
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.83305507
19Parkinsons disease_Homo sapiens_hsa050121.75970415
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72946326
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70247568
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67665623
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61407497
24RNA degradation_Homo sapiens_hsa030181.60257387
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.56180625
26Ether lipid metabolism_Homo sapiens_hsa005651.52731905
27Tryptophan metabolism_Homo sapiens_hsa003801.46268591
28Caffeine metabolism_Homo sapiens_hsa002321.45969006
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40609837
30Taste transduction_Homo sapiens_hsa047421.34986117
31Selenocompound metabolism_Homo sapiens_hsa004501.34096219
32Regulation of autophagy_Homo sapiens_hsa041401.29551995
33Huntingtons disease_Homo sapiens_hsa050161.22649254
34Peroxisome_Homo sapiens_hsa041461.21943176
35One carbon pool by folate_Homo sapiens_hsa006701.20866704
36Olfactory transduction_Homo sapiens_hsa047401.17285596
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14814989
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12477545
39Alzheimers disease_Homo sapiens_hsa050101.08760809
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.07083384
41Cardiac muscle contraction_Homo sapiens_hsa042601.05723386
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04785130
43Morphine addiction_Homo sapiens_hsa050321.04553817
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01612923
45Proteasome_Homo sapiens_hsa030500.99603296
46Chemical carcinogenesis_Homo sapiens_hsa052040.98563796
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97717149
48GABAergic synapse_Homo sapiens_hsa047270.92236431
49Retinol metabolism_Homo sapiens_hsa008300.92227991
50Mismatch repair_Homo sapiens_hsa034300.89770353
51Purine metabolism_Homo sapiens_hsa002300.88863232
52ABC transporters_Homo sapiens_hsa020100.87725396
53Insulin secretion_Homo sapiens_hsa049110.86046329
54Primary immunodeficiency_Homo sapiens_hsa053400.84806855
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84067984
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82622938
57Glutamatergic synapse_Homo sapiens_hsa047240.81862106
58Circadian entrainment_Homo sapiens_hsa047130.80375934
59beta-Alanine metabolism_Homo sapiens_hsa004100.78948250
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.78810853
61Glycerolipid metabolism_Homo sapiens_hsa005610.75387026
62Nucleotide excision repair_Homo sapiens_hsa034200.75209635
63Serotonergic synapse_Homo sapiens_hsa047260.75079889
64Pyrimidine metabolism_Homo sapiens_hsa002400.72608313
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.69888314
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.69349646
67Arachidonic acid metabolism_Homo sapiens_hsa005900.69165675
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68518862
69Circadian rhythm_Homo sapiens_hsa047100.67265445
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65994668
71Collecting duct acid secretion_Homo sapiens_hsa049660.65975761
72Metabolic pathways_Homo sapiens_hsa011000.63458288
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62965478
74Sulfur metabolism_Homo sapiens_hsa009200.59568549
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58691211
76Dorso-ventral axis formation_Homo sapiens_hsa043200.55972697
77Steroid biosynthesis_Homo sapiens_hsa001000.53599085
78Salivary secretion_Homo sapiens_hsa049700.52647695
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52400732
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52159617
81Calcium signaling pathway_Homo sapiens_hsa040200.52114514
82RNA transport_Homo sapiens_hsa030130.51049966
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50721962
84Dopaminergic synapse_Homo sapiens_hsa047280.50195252
85Ovarian steroidogenesis_Homo sapiens_hsa049130.49169437
86Fat digestion and absorption_Homo sapiens_hsa049750.48563482
87Base excision repair_Homo sapiens_hsa034100.45600698
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43334294
89Hedgehog signaling pathway_Homo sapiens_hsa043400.41838152
90Fatty acid degradation_Homo sapiens_hsa000710.39985852
91Fatty acid elongation_Homo sapiens_hsa000620.39957770
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37706591
93DNA replication_Homo sapiens_hsa030300.37062486
94Basal cell carcinoma_Homo sapiens_hsa052170.33014938
95Asthma_Homo sapiens_hsa053100.32612087
96Amphetamine addiction_Homo sapiens_hsa050310.32034716
97Histidine metabolism_Homo sapiens_hsa003400.31711454
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31311658
99Fatty acid metabolism_Homo sapiens_hsa012120.29923354
100Cocaine addiction_Homo sapiens_hsa050300.29651532

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