ARL17A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translation, ncRNA-mediated (GO:0045974)4.85773714
2negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.85773714
3negative regulation of translation, ncRNA-mediated (GO:0040033)4.85773714
4monoubiquitinated protein deubiquitination (GO:0035520)4.81891406
5histone H3-K4 trimethylation (GO:0080182)4.45042369
6interkinetic nuclear migration (GO:0022027)4.38708076
7neural tube formation (GO:0001841)4.24181862
8histone H3-K9 methylation (GO:0051567)3.90209726
9indolalkylamine metabolic process (GO:0006586)3.81718997
10positive regulation of developmental pigmentation (GO:0048087)3.78878685
11rRNA catabolic process (GO:0016075)3.77311355
12regulation of hippo signaling (GO:0035330)3.73869519
13tryptophan catabolic process (GO:0006569)3.71084227
14indole-containing compound catabolic process (GO:0042436)3.71084227
15indolalkylamine catabolic process (GO:0046218)3.71084227
16cilium or flagellum-dependent cell motility (GO:0001539)3.65177339
17snRNA transcription (GO:0009301)3.52034881
18protein K48-linked deubiquitination (GO:0071108)3.49722468
19peptidyl-lysine trimethylation (GO:0018023)3.45634316
20kynurenine metabolic process (GO:0070189)3.39589751
21protein K11-linked deubiquitination (GO:0035871)3.37487586
22histone H3-K9 modification (GO:0061647)3.36745110
23histone lysine methylation (GO:0034968)3.34845413
24positive regulation of granulocyte differentiation (GO:0030854)3.32153074
25histone H3-K4 methylation (GO:0051568)3.31689442
26peptidyl-lysine methylation (GO:0018022)3.28468503
27tryptophan metabolic process (GO:0006568)3.26149599
28regulation of pigment cell differentiation (GO:0050932)3.22114249
29regulation of telomere maintenance (GO:0032204)3.19886910
30detection of light stimulus involved in visual perception (GO:0050908)3.16684780
31detection of light stimulus involved in sensory perception (GO:0050962)3.16684780
32double-strand break repair via homologous recombination (GO:0000724)3.16609142
33detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15651500
34recombinational repair (GO:0000725)3.12034400
35replication fork processing (GO:0031297)3.11566221
36microtubule anchoring (GO:0034453)3.06625815
37establishment of protein localization to Golgi (GO:0072600)3.06608843
38cellular response to ethanol (GO:0071361)3.04545687
39reciprocal meiotic recombination (GO:0007131)3.00968010
40reciprocal DNA recombination (GO:0035825)3.00968010
41regulation of B cell receptor signaling pathway (GO:0050855)3.00883474
42regulation of sarcomere organization (GO:0060297)3.00843380
43DNA damage induced protein phosphorylation (GO:0006975)2.99661482
44protein K63-linked deubiquitination (GO:0070536)2.98850807
45phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.96262601
46regulation of DNA endoreduplication (GO:0032875)2.82659164
47cytoplasmic mRNA processing body assembly (GO:0033962)2.81692805
48reflex (GO:0060004)2.81169511
49DNA deamination (GO:0045006)2.81067025
50signal peptide processing (GO:0006465)2.79173109
51regulation of posttranscriptional gene silencing (GO:0060147)2.75672732
52regulation of gene silencing by miRNA (GO:0060964)2.75672732
53regulation of gene silencing by RNA (GO:0060966)2.75672732
54behavioral response to nicotine (GO:0035095)2.75510822
55negative regulation of telomere maintenance (GO:0032205)2.71524246
56regulation of histone H3-K4 methylation (GO:0051569)2.69103728
57positive regulation of mRNA catabolic process (GO:0061014)2.66663720
58mitotic sister chromatid cohesion (GO:0007064)2.66610806
59histone methylation (GO:0016571)2.65386478
60regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.64964256
61positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.64964256
62tachykinin receptor signaling pathway (GO:0007217)2.64675349
63regulation of establishment of cell polarity (GO:2000114)2.64548208
64histone-serine phosphorylation (GO:0035404)2.63328569
65positive regulation of histone H3-K4 methylation (GO:0051571)2.62855542
66regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.62062549
67positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.62062549
68meiotic chromosome segregation (GO:0045132)2.61631664
69RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.60622484
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60121945
71replicative senescence (GO:0090399)2.59822808
72positive regulation of CREB transcription factor activity (GO:0032793)2.59683255
73regulation of telomere maintenance via telomerase (GO:0032210)2.59125871
74gene silencing by RNA (GO:0031047)2.56718898
75centriole replication (GO:0007099)2.56167442
76photoreceptor cell maintenance (GO:0045494)2.53410995
77negative regulation of calcium ion transport into cytosol (GO:0010523)2.53103934
78cellular ketone body metabolic process (GO:0046950)2.50437006
79DNA methylation (GO:0006306)2.50336395
80DNA alkylation (GO:0006305)2.50336395
81axoneme assembly (GO:0035082)2.44100891
82lipid translocation (GO:0034204)2.43995359
83phospholipid translocation (GO:0045332)2.43995359
84DNA methylation involved in gamete generation (GO:0043046)2.42098632
85regulation of mRNA catabolic process (GO:0061013)2.41871887
86sister chromatid cohesion (GO:0007062)2.41366219
87pre-miRNA processing (GO:0031054)2.41145018
88DNA methylation or demethylation (GO:0044728)2.40170350
89microtubule nucleation (GO:0007020)2.39871448
90regulation of MHC class I biosynthetic process (GO:0045343)2.39795559
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.39444913
92behavioral response to ethanol (GO:0048149)2.39217830
93nucleus localization (GO:0051647)2.39216337
94spinal cord motor neuron differentiation (GO:0021522)2.38349936
95fucose catabolic process (GO:0019317)2.37694033
96L-fucose metabolic process (GO:0042354)2.37694033
97L-fucose catabolic process (GO:0042355)2.37694033
98cellular response to sterol (GO:0036315)2.37125604
99negative regulation of DNA-dependent DNA replication (GO:2000104)2.35176766
100negative regulation of smooth muscle cell differentiation (GO:0051151)2.35011700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.07099428
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03713146
3GBX2_23144817_ChIP-Seq_PC3_Human2.77253219
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58257755
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.56902903
6IGF1R_20145208_ChIP-Seq_DFB_Human2.56087435
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52143048
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43168946
9VDR_22108803_ChIP-Seq_LS180_Human2.41887597
10EZH2_22144423_ChIP-Seq_EOC_Human2.34845414
11FUS_26573619_Chip-Seq_HEK293_Human2.27095801
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23648749
13EWS_26573619_Chip-Seq_HEK293_Human2.21998610
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.20521452
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.18181541
16TAF15_26573619_Chip-Seq_HEK293_Human2.09164850
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03941692
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03015284
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00665873
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.98663924
21STAT3_23295773_ChIP-Seq_U87_Human1.96962356
22E2F7_22180533_ChIP-Seq_HELA_Human1.95779111
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92214096
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.91284960
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86101425
26ER_23166858_ChIP-Seq_MCF-7_Human1.85242155
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83025091
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82783423
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79718184
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.76847366
31TCF4_23295773_ChIP-Seq_U87_Human1.73945131
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.70610391
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67859075
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.67859075
35P300_19829295_ChIP-Seq_ESCs_Human1.67759131
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67684867
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.66742158
38CBP_20019798_ChIP-Seq_JUKART_Human1.64090477
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64090477
40TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.57734771
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56323969
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50632002
43SMAD4_21799915_ChIP-Seq_A2780_Human1.50448562
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.42548072
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.37729298
46* AR_21572438_ChIP-Seq_LNCaP_Human1.36742868
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36642605
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36609403
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.36368064
50IRF1_19129219_ChIP-ChIP_H3396_Human1.35427237
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34900921
52BCAT_22108803_ChIP-Seq_LS180_Human1.34186776
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32103494
54AR_25329375_ChIP-Seq_VCAP_Human1.32065144
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.30702836
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26719637
57TCF4_22108803_ChIP-Seq_LS180_Human1.23926559
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23406889
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22424537
60RUNX2_22187159_ChIP-Seq_PCA_Human1.21578128
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.20710008
62TP53_16413492_ChIP-PET_HCT116_Human1.19633188
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19416797
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19041038
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.18795406
66TP53_22573176_ChIP-Seq_HFKS_Human1.16246132
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15691993
68SCL_19346495_ChIP-Seq_HPC-7_Human1.15250387
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14731181
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14311756
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14000211
72GATA3_26560356_Chip-Seq_TH2_Human1.13940527
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.13585070
74TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11478915
75CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11396687
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11378614
77RUNX_20019798_ChIP-Seq_JUKART_Human1.11124346
78DROSHA_22980978_ChIP-Seq_HELA_Human1.08935829
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08753572
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05015885
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.04795616
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.04308033
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.02986349
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02582335
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.01093177
86OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00619390
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98876078
88CIITA_25753668_ChIP-Seq_RAJI_Human0.98096678
89GATA3_27048872_Chip-Seq_THYMUS_Human0.97971778
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97943315
91MYC_18940864_ChIP-ChIP_HL60_Human0.97516266
92RNF2_27304074_Chip-Seq_NSC_Mouse0.96552064
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96546785
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.95015694
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94953946
96KDM2B_26808549_Chip-Seq_REH_Human0.94797450
97AHR_22903824_ChIP-Seq_MCF-7_Human0.94785796
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.94418685
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.92254862
100NANOG_19829295_ChIP-Seq_ESCs_Human0.92183929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.61167541
2MP0000569_abnormal_digit_pigmentation3.93358947
3MP0003646_muscle_fatigue3.38945515
4MP0003195_calcinosis3.04615130
5MP0008877_abnormal_DNA_methylation2.66810679
6MP0004043_abnormal_pH_regulation2.33467329
7MP0010094_abnormal_chromosome_stability2.27184319
8MP0000372_irregular_coat_pigmentation2.10180213
9MP0005645_abnormal_hypothalamus_physiol2.09035520
10MP0003763_abnormal_thymus_physiology1.87083634
11MP0002396_abnormal_hematopoietic_system1.86641348
12MP0005551_abnormal_eye_electrophysiolog1.78787138
13MP0008058_abnormal_DNA_repair1.77653572
14MP0009046_muscle_twitch1.75803822
15MP0005075_abnormal_melanosome_morpholog1.73217843
16MP0001501_abnormal_sleep_pattern1.70344046
17MP0005174_abnormal_tail_pigmentation1.67342497
18MP0008995_early_reproductive_senescence1.61580632
19MP0005646_abnormal_pituitary_gland1.60977039
20MP0002009_preneoplasia1.58951523
21MP0008961_abnormal_basal_metabolism1.58567807
22MP0002102_abnormal_ear_morphology1.55087274
23MP0000015_abnormal_ear_pigmentation1.53092818
24MP0000427_abnormal_hair_cycle1.44123165
25MP0004142_abnormal_muscle_tone1.38246864
26MP0003045_fibrosis1.37894512
27MP0001986_abnormal_taste_sensitivity1.37033443
28MP0000631_abnormal_neuroendocrine_gland1.35105647
29MP0009697_abnormal_copulation1.29106376
30MP0002138_abnormal_hepatobiliary_system1.28993304
31MP0006292_abnormal_olfactory_placode1.28341254
32MP0004381_abnormal_hair_follicle1.25475011
33MP0003787_abnormal_imprinting1.23818431
34MP0005670_abnormal_white_adipose1.21982495
35MP0002095_abnormal_skin_pigmentation1.21679473
36MP0002928_abnormal_bile_duct1.20636194
37MP0001835_abnormal_antigen_presentation1.18572082
38MP0009745_abnormal_behavioral_response1.18031009
39MP0006072_abnormal_retinal_apoptosis1.16982221
40MP0008872_abnormal_physiological_respon1.16027904
41MP0000383_abnormal_hair_follicle1.14171291
42MP0005253_abnormal_eye_physiology1.13173815
43MP0006276_abnormal_autonomic_nervous1.12694468
44MP0003786_premature_aging1.12586414
45MP0005266_abnormal_metabolism1.12084898
46MP0001968_abnormal_touch/_nociception1.06350918
47MP0003718_maternal_effect1.06151762
48MP0003136_yellow_coat_color1.04207828
49MP0002168_other_aberrant_phenotype1.04067718
50MP0004130_abnormal_muscle_cell1.04019335
51MP0005310_abnormal_salivary_gland1.02981218
52MP0001485_abnormal_pinna_reflex1.02941555
53MP0001800_abnormal_humoral_immune1.01620347
54MP0003252_abnormal_bile_duct1.01336345
55MP0004133_heterotaxia0.98865993
56MP0004145_abnormal_muscle_electrophysio0.98323811
57MP0004147_increased_porphyrin_level0.97896234
58MP0003890_abnormal_embryonic-extraembry0.95807800
59MP0003698_abnormal_male_reproductive0.95348454
60MP0005220_abnormal_exocrine_pancreas0.94779480
61MP0001486_abnormal_startle_reflex0.94582258
62MP0000703_abnormal_thymus_morphology0.94482879
63MP0002638_abnormal_pupillary_reflex0.94159598
64MP0000371_diluted_coat_color0.93044686
65MP0002163_abnormal_gland_morphology0.87525200
66MP0002876_abnormal_thyroid_physiology0.86211029
67MP0004808_abnormal_hematopoietic_stem0.86167091
68MP0005389_reproductive_system_phenotype0.86058250
69MP0005395_other_phenotype0.84185333
70MP0004924_abnormal_behavior0.83353599
71MP0005386_behavior/neurological_phenoty0.83353599
72MP0003111_abnormal_nucleus_morphology0.82896072
73MP0001929_abnormal_gametogenesis0.80740556
74MP0002160_abnormal_reproductive_system0.80548204
75MP0005671_abnormal_response_to0.80313560
76MP0003077_abnormal_cell_cycle0.80251843
77MP0002938_white_spotting0.79624668
78MP0002234_abnormal_pharynx_morphology0.77763222
79MP0002067_abnormal_sensory_capabilities0.76431584
80MP0002166_altered_tumor_susceptibility0.76249309
81MP0002398_abnormal_bone_marrow0.75970896
82MP0008007_abnormal_cellular_replicative0.75446444
83MP0000689_abnormal_spleen_morphology0.74666236
84MP0010307_abnormal_tumor_latency0.73288543
85MP0003943_abnormal_hepatobiliary_system0.72657858
86MP0004742_abnormal_vestibular_system0.71489769
87MP0002693_abnormal_pancreas_physiology0.70771096
88MP0002210_abnormal_sex_determination0.70404974
89MP0000653_abnormal_sex_gland0.70152246
90MP0003878_abnormal_ear_physiology0.70026693
91MP0005377_hearing/vestibular/ear_phenot0.70026693
92MP0001919_abnormal_reproductive_system0.69917887
93MP0001873_stomach_inflammation0.69673021
94MP0002557_abnormal_social/conspecific_i0.68426965
95MP0005187_abnormal_penis_morphology0.68301651
96MP0005448_abnormal_energy_balance0.66766696
97MP0001324_abnormal_eye_pigmentation0.66675961
98MP0002064_seizures0.66555905
99MP0000470_abnormal_stomach_morphology0.65601352
100MP0003693_abnormal_embryo_hatching0.65120846

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.25001872
2Pancreatic cysts (HP:0001737)3.92821502
3Hyperventilation (HP:0002883)3.88585042
4Gaze-evoked nystagmus (HP:0000640)3.52907198
5Pancreatic fibrosis (HP:0100732)3.22221102
6Chronic hepatic failure (HP:0100626)3.18258265
7Progressive cerebellar ataxia (HP:0002073)3.08570952
8Abnormality of the renal cortex (HP:0011035)3.08119868
9Molar tooth sign on MRI (HP:0002419)3.07766860
10Abnormality of midbrain morphology (HP:0002418)3.07766860
11Chromsome breakage (HP:0040012)3.05506834
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03013393
13Nephronophthisis (HP:0000090)2.87744085
14True hermaphroditism (HP:0010459)2.84639035
15Abnormality of the renal medulla (HP:0100957)2.80011011
16Protruding tongue (HP:0010808)2.76078013
17Congenital stationary night blindness (HP:0007642)2.75470729
18Clumsiness (HP:0002312)2.66858197
19Attenuation of retinal blood vessels (HP:0007843)2.61217649
20Ectopic kidney (HP:0000086)2.59118765
21Thyroiditis (HP:0100646)2.57337334
22Severe combined immunodeficiency (HP:0004430)2.54971754
23Panhypogammaglobulinemia (HP:0003139)2.52344864
24Volvulus (HP:0002580)2.49905764
25Fair hair (HP:0002286)2.47743145
26Medial flaring of the eyebrow (HP:0010747)2.38264437
27Cystic liver disease (HP:0006706)2.37527595
28Renal cortical cysts (HP:0000803)2.31259107
29Patellar aplasia (HP:0006443)2.25501618
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.25483660
31Febrile seizures (HP:0002373)2.24336599
32Clubbing of toes (HP:0100760)2.22523870
33Broad-based gait (HP:0002136)2.21922859
34Tubulointerstitial nephritis (HP:0001970)2.21310125
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.21152656
36Tented upper lip vermilion (HP:0010804)2.19975352
37Duplicated collecting system (HP:0000081)2.18222045
38Abnormality of the fingertips (HP:0001211)2.16337288
39Abnormality of DNA repair (HP:0003254)2.15080918
40Abnormality of the renal collecting system (HP:0004742)2.14465006
41Abnormality of chromosome stability (HP:0003220)2.11938544
42Sloping forehead (HP:0000340)2.10359837
43Abnormality of B cell number (HP:0010975)2.09847010
44Widely spaced teeth (HP:0000687)2.07134531
45Bile duct proliferation (HP:0001408)2.04185728
46Abnormal biliary tract physiology (HP:0012439)2.04185728
47Absent speech (HP:0001344)2.04022162
48Aplasia/Hypoplasia of the patella (HP:0006498)2.03917872
49Abnormality of the aortic arch (HP:0012303)2.03609194
50Hypoplastic iliac wings (HP:0002866)2.02458605
51Stomach cancer (HP:0012126)2.00816645
52Truncal obesity (HP:0001956)1.99045622
53Enlarged kidneys (HP:0000105)1.97172538
54Abnormal delayed hypersensitivity skin test (HP:0002963)1.97020426
55Bony spicule pigmentary retinopathy (HP:0007737)1.96967600
56Abolished electroretinogram (ERG) (HP:0000550)1.96452268
57Poor coordination (HP:0002370)1.95921028
58Prominent nose (HP:0000448)1.95491166
59Highly arched eyebrow (HP:0002553)1.93447450
60Abnormality of the ileum (HP:0001549)1.92953956
61Hypothermia (HP:0002045)1.89736509
62Progressive inability to walk (HP:0002505)1.88529164
63Aplasia/Hypoplasia of the tibia (HP:0005772)1.86530590
64Central scotoma (HP:0000603)1.84974122
65Congenital primary aphakia (HP:0007707)1.84497882
66Generalized hypopigmentation of hair (HP:0011358)1.83823932
67Increased neuronal autofluorescent lipopigment (HP:0002074)1.83676263
68Meckel diverticulum (HP:0002245)1.80586080
69Inability to walk (HP:0002540)1.79906686
70Gait imbalance (HP:0002141)1.78939337
71Polydipsia (HP:0001959)1.78582124
72Abnormal drinking behavior (HP:0030082)1.78582124
73Constricted visual fields (HP:0001133)1.78534947
74Postaxial foot polydactyly (HP:0001830)1.78091694
75Dialeptic seizures (HP:0011146)1.77734826
76Acute myeloid leukemia (HP:0004808)1.76685685
77Neoplasm of the adrenal cortex (HP:0100641)1.76662719
78Acute lymphatic leukemia (HP:0006721)1.75175194
79Hypoplasia of the thymus (HP:0000778)1.75074216
80Nephrogenic diabetes insipidus (HP:0009806)1.74559155
81Ureteral obstruction (HP:0006000)1.74164912
82Congenital hepatic fibrosis (HP:0002612)1.74097901
83Intestinal atresia (HP:0011100)1.74096391
84Combined immunodeficiency (HP:0005387)1.71317984
85Birth length less than 3rd percentile (HP:0003561)1.71311874
86Ureteral stenosis (HP:0000071)1.71042682
87IgG deficiency (HP:0004315)1.69839021
88Absence seizures (HP:0002121)1.68148758
89Ketosis (HP:0001946)1.68099671
90Sclerocornea (HP:0000647)1.67479170
91Abnormality of the pons (HP:0007361)1.67240903
92Hypoplasia of the pons (HP:0012110)1.67056868
93Abnormality of the nasal septum (HP:0000419)1.66664143
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.65334633
95Genital tract atresia (HP:0001827)1.63578911
96Ketoacidosis (HP:0001993)1.63259806
97Large for gestational age (HP:0001520)1.62567487
98Abnormality of eosinophils (HP:0001879)1.61908020
99Abnormality of T cell number (HP:0011839)1.61639909
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60423683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.57202936
2INSRR2.88067377
3BMPR1B2.79879819
4TAOK32.50942289
5MAP4K22.42201974
6NUAK12.23009850
7MAP2K62.12763865
8TLK12.10767658
9CDK121.84105798
10ACVR1B1.71285570
11SIK21.68740417
12AKT31.64461257
13MKNK21.60841699
14CAMK1G1.48385852
15CAMK1D1.47678629
16BRSK21.42760247
17WNK31.41930733
18TEC1.39234845
19ADRBK21.37103329
20MAPK131.34171321
21ZAK1.34142731
22TAOK21.31598398
23CASK1.21732473
24PIK3CG1.21441833
25WNK41.20950518
26TXK1.17693731
27MAP3K41.13825516
28TNK21.11316730
29BRD41.08273057
30NLK1.08173220
31ATR1.03713556
32STK391.00354398
33FGFR20.99712570
34KIT0.97325984
35PINK10.95564615
36MAP3K70.95097844
37WNK10.91689764
38IRAK10.89566383
39ITK0.89440349
40TRPM70.88052593
41GRK10.87693185
42MAPK110.87277189
43BTK0.86142847
44LATS10.85796212
45MELK0.84002783
46CAMKK20.83726328
47RIPK40.83382349
48CHEK20.83288038
49PRKAA20.81482533
50CAMK40.79016498
51MAP4K10.77682936
52SYK0.76981131
53MKNK10.75392354
54MARK30.72632782
55PIK3CA0.72398172
56MAP3K50.70567456
57NTRK30.70462308
58CDC70.70090381
59SGK20.69867748
60BMPR20.68668202
61TGFBR10.68585274
62STK38L0.66594069
63ATM0.65040756
64FGFR30.64255809
65PNCK0.63782331
66CDK30.63388435
67CSNK1A1L0.62458427
68FLT30.60892143
69PRKAA10.60112362
70OXSR10.59729266
71CAMK10.58093136
72BLK0.56987477
73CDK80.55956196
74SRPK10.54819918
75PAK30.54186694
76EPHA30.47541277
77EEF2K0.47043648
78CHUK0.46780491
79NME10.45932292
80STK110.45583835
81DAPK20.45155723
82STK380.45024380
83PRKCQ0.43576821
84CSNK1D0.43570031
85STK30.43252174
86ADRBK10.42573785
87SGK10.41896467
88MAPKAPK30.41155385
89GRK60.40967822
90TNIK0.40374766
91LYN0.40170964
92JAK30.39762098
93LCK0.39599257
94CHEK10.38767451
95IKBKB0.38231401
96MAPKAPK50.35458672
97EIF2AK30.33713017
98OBSCN0.33589988
99CDK10.33465827
100TAF10.33223283

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.07360622
2Fanconi anemia pathway_Homo sapiens_hsa034602.81668415
3Lysine degradation_Homo sapiens_hsa003102.24594074
4ABC transporters_Homo sapiens_hsa020102.21481880
5Non-homologous end-joining_Homo sapiens_hsa034502.16930914
6Phototransduction_Homo sapiens_hsa047442.09058294
7Primary immunodeficiency_Homo sapiens_hsa053402.07597054
8Butanoate metabolism_Homo sapiens_hsa006501.97131174
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89236348
10RNA polymerase_Homo sapiens_hsa030201.77682079
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.71134785
12Dorso-ventral axis formation_Homo sapiens_hsa043201.65041811
13One carbon pool by folate_Homo sapiens_hsa006701.57923943
14Taste transduction_Homo sapiens_hsa047421.57699280
15Nicotine addiction_Homo sapiens_hsa050331.55017172
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54764880
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.49957047
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49937387
19Olfactory transduction_Homo sapiens_hsa047401.41796561
20Linoleic acid metabolism_Homo sapiens_hsa005911.40905157
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40605109
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39377834
23Nitrogen metabolism_Homo sapiens_hsa009101.38261326
24Selenocompound metabolism_Homo sapiens_hsa004501.35930288
25Basal transcription factors_Homo sapiens_hsa030221.35309479
26Graft-versus-host disease_Homo sapiens_hsa053321.27714311
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25825186
28Tryptophan metabolism_Homo sapiens_hsa003801.19284420
29RNA degradation_Homo sapiens_hsa030181.17202605
30Regulation of autophagy_Homo sapiens_hsa041401.12890926
31Morphine addiction_Homo sapiens_hsa050321.12743432
32Asthma_Homo sapiens_hsa053101.11331080
33Ether lipid metabolism_Homo sapiens_hsa005651.10311192
34Circadian rhythm_Homo sapiens_hsa047101.09344292
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07167188
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.05691133
37Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97501724
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96875298
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96441204
40Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96121363
41Autoimmune thyroid disease_Homo sapiens_hsa053200.91405935
42Glycerolipid metabolism_Homo sapiens_hsa005610.90954904
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90278206
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89344345
45Calcium signaling pathway_Homo sapiens_hsa040200.88403286
46FoxO signaling pathway_Homo sapiens_hsa040680.87886092
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86752781
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.85136356
49Allograft rejection_Homo sapiens_hsa053300.84431218
50Propanoate metabolism_Homo sapiens_hsa006400.83607189
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83297173
52Type II diabetes mellitus_Homo sapiens_hsa049300.82724641
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79746372
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79151593
55Glutamatergic synapse_Homo sapiens_hsa047240.78886794
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77900912
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.75689427
58mRNA surveillance pathway_Homo sapiens_hsa030150.75644759
59Circadian entrainment_Homo sapiens_hsa047130.74516878
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74072463
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73925203
62Salivary secretion_Homo sapiens_hsa049700.71926319
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70553380
64Ovarian steroidogenesis_Homo sapiens_hsa049130.70399979
65T cell receptor signaling pathway_Homo sapiens_hsa046600.69971323
66Type I diabetes mellitus_Homo sapiens_hsa049400.69735844
67Serotonergic synapse_Homo sapiens_hsa047260.69668822
68Cholinergic synapse_Homo sapiens_hsa047250.68140230
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68137919
70GABAergic synapse_Homo sapiens_hsa047270.67161160
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.62882234
72Cell cycle_Homo sapiens_hsa041100.60452469
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59434678
74Herpes simplex infection_Homo sapiens_hsa051680.59334390
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58541247
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58068397
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57408759
78Purine metabolism_Homo sapiens_hsa002300.56989689
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.56646534
80RNA transport_Homo sapiens_hsa030130.55872338
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55714158
82Oxytocin signaling pathway_Homo sapiens_hsa049210.55154989
83mTOR signaling pathway_Homo sapiens_hsa041500.55086239
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52840403
85Choline metabolism in cancer_Homo sapiens_hsa052310.52759613
86Insulin secretion_Homo sapiens_hsa049110.52169148
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50988603
88Inositol phosphate metabolism_Homo sapiens_hsa005620.50799526
89Long-term depression_Homo sapiens_hsa047300.47990149
90Insulin resistance_Homo sapiens_hsa049310.47094896
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.46363557
92Retinol metabolism_Homo sapiens_hsa008300.46191654
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44674412
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43158484
95B cell receptor signaling pathway_Homo sapiens_hsa046620.42687283
96Nucleotide excision repair_Homo sapiens_hsa034200.41517930
97Chemical carcinogenesis_Homo sapiens_hsa052040.40308785
98Fatty acid biosynthesis_Homo sapiens_hsa000610.39494678
99MicroRNAs in cancer_Homo sapiens_hsa052060.39464611
100Platelet activation_Homo sapiens_hsa046110.39100201

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »