ARL16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). This protein has been shown to have an inhibitory role in the cellular antiviral response. This gene product interacts with the C-terminal domain of the DEXD/H-box helicase 58 (DDX58) gene product. This interaction was found to suppress the association between the DDX58 gene product and RNA, thereby negatively regulating the activity of the DDX58 gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.90258660
2proline biosynthetic process (GO:0006561)6.49868011
3replication fork processing (GO:0031297)5.55736931
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.16235088
5proline metabolic process (GO:0006560)4.95414485
6ATP synthesis coupled proton transport (GO:0015986)4.94510564
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.94510564
8transcription from mitochondrial promoter (GO:0006390)4.79999881
9oxidative demethylation (GO:0070989)4.78131955
10cullin deneddylation (GO:0010388)4.76660354
11behavioral response to nicotine (GO:0035095)4.71989530
12protein neddylation (GO:0045116)4.63616286
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.59316344
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.59316344
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.48988208
16viral mRNA export from host cell nucleus (GO:0046784)4.48189621
17DNA strand renaturation (GO:0000733)4.47225865
18positive regulation of protein homooligomerization (GO:0032464)4.47198389
19protein deneddylation (GO:0000338)4.27462516
20maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.25827997
21respiratory electron transport chain (GO:0022904)4.18747666
22negative regulation of response to food (GO:0032096)4.18540259
23negative regulation of appetite (GO:0032099)4.18540259
24electron transport chain (GO:0022900)4.17263718
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.14548814
26sequestering of actin monomers (GO:0042989)4.05817675
27DNA integration (GO:0015074)4.05766745
28maturation of 5.8S rRNA (GO:0000460)4.00831909
29poly(A)+ mRNA export from nucleus (GO:0016973)3.97302654
30GDP-mannose metabolic process (GO:0019673)3.94664543
31cellular response to ATP (GO:0071318)3.84874039
32embryonic process involved in female pregnancy (GO:0060136)3.76531738
33platelet dense granule organization (GO:0060155)3.72682911
34cytochrome complex assembly (GO:0017004)3.70263920
35regulation of protein homooligomerization (GO:0032462)3.67922887
36pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.63631756
37protein-cofactor linkage (GO:0018065)3.60720263
38negative regulation of heart rate (GO:0010459)3.58710467
39regulation of mitochondrial translation (GO:0070129)3.49962294
40preassembly of GPI anchor in ER membrane (GO:0016254)3.49898577
41pyrimidine nucleotide catabolic process (GO:0006244)3.47852483
42synaptic vesicle endocytosis (GO:0048488)3.43473672
43DNA double-strand break processing (GO:0000729)3.39840839
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37084812
45ribosomal small subunit assembly (GO:0000028)3.36531918
46positive regulation of DNA repair (GO:0045739)3.30800145
47mannosylation (GO:0097502)3.30640737
48base-excision repair, AP site formation (GO:0006285)3.29677625
49positive regulation of prostaglandin secretion (GO:0032308)3.29418605
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29143319
51GTP biosynthetic process (GO:0006183)3.29033129
52deoxyribonucleotide catabolic process (GO:0009264)3.28659542
53negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.25145510
54DNA ligation (GO:0006266)3.24257118
55somatic hypermutation of immunoglobulin genes (GO:0016446)3.22722566
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22722566
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.20396446
58proteasome assembly (GO:0043248)3.19718518
59ubiquinone biosynthetic process (GO:0006744)3.19499669
60regulation of cAMP-dependent protein kinase activity (GO:2000479)3.18909718
61negative regulation of JAK-STAT cascade (GO:0046426)3.18436705
62mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15931467
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15657402
64viral transcription (GO:0019083)3.14903253
65kinetochore assembly (GO:0051382)3.14659071
66chaperone-mediated protein transport (GO:0072321)3.13828631
67protein complex biogenesis (GO:0070271)3.11636788
68water-soluble vitamin biosynthetic process (GO:0042364)3.11247724
69tRNA processing (GO:0008033)3.09773757
70hydrogen ion transmembrane transport (GO:1902600)3.08404882
71telomere maintenance via semi-conservative replication (GO:0032201)3.08379917
72positive regulation of developmental pigmentation (GO:0048087)3.05891794
73purine nucleoside triphosphate biosynthetic process (GO:0009145)3.05648464
74translational termination (GO:0006415)3.04873542
75deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.03721371
76regulation of cellular amino acid metabolic process (GO:0006521)3.03328152
77inner mitochondrial membrane organization (GO:0007007)3.03033284
78nucleotide-excision repair, DNA gap filling (GO:0006297)3.02981667
79deoxyribose phosphate catabolic process (GO:0046386)3.02916934
80purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.99755482
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97830639
82mitochondrial respiratory chain complex I assembly (GO:0032981)2.97391914
83NADH dehydrogenase complex assembly (GO:0010257)2.97391914
84mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.97391914
85neuron fate specification (GO:0048665)2.96871068
86peptidyl-histidine modification (GO:0018202)2.96774582
87auditory receptor cell stereocilium organization (GO:0060088)2.95554969
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95390220
89regulation of mitochondrial depolarization (GO:0051900)2.95302467
90ubiquinone metabolic process (GO:0006743)2.95283905
91cotranslational protein targeting to membrane (GO:0006613)2.94851702
92regulation of response to food (GO:0032095)2.94460687
93pyrimidine nucleobase catabolic process (GO:0006208)2.94272929
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93861268
95translational elongation (GO:0006414)2.92335785
96intracellular protein transmembrane import (GO:0044743)2.91449040
97protein targeting to ER (GO:0045047)2.90608907
98ATP biosynthetic process (GO:0006754)2.90509909
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.90452172
100DNA damage response, detection of DNA damage (GO:0042769)2.89507476
101DNA demethylation (GO:0080111)2.88345953
102proton transport (GO:0015992)2.87733133
103signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86937920
104signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86937920
105signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86937920
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86637032
107presynaptic membrane organization (GO:0097090)2.86570271
108regulation of respiratory system process (GO:0044065)2.85395151
109epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85256625
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85187757
111negative regulation of ligase activity (GO:0051352)2.85187757
1122-deoxyribonucleotide metabolic process (GO:0009394)2.83389664
113regulation of appetite (GO:0032098)2.83113085
114hydrogen transport (GO:0006818)2.82914799
115signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.82029118
116intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.82029118
117presynaptic membrane assembly (GO:0097105)2.81662731
118protein localization to endoplasmic reticulum (GO:0070972)2.79833038
119maturation of SSU-rRNA (GO:0030490)2.79259373
120regulation of cilium movement (GO:0003352)2.77048275
121establishment of protein localization to endoplasmic reticulum (GO:0072599)2.74828785
122protein targeting to mitochondrion (GO:0006626)2.74359703
123regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.74228323
124cellular component biogenesis (GO:0044085)2.73040015
125C-terminal protein lipidation (GO:0006501)2.72883186
126L-methionine salvage (GO:0071267)2.72496335
127L-methionine biosynthetic process (GO:0071265)2.72496335
128amino acid salvage (GO:0043102)2.72496335
129inner ear receptor stereocilium organization (GO:0060122)2.71427859
130translation (GO:0006412)2.71274118
131negative regulation of protein oligomerization (GO:0032460)2.71244832
132signal transduction involved in cell cycle checkpoint (GO:0072395)2.71131251
133negative regulation of dendrite morphogenesis (GO:0050774)2.70789582
134negative regulation of telomere maintenance (GO:0032205)2.70789463
135signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70484474
136signal transduction involved in DNA damage checkpoint (GO:0072422)2.70484474
137UTP biosynthetic process (GO:0006228)2.69971551
138intraciliary transport (GO:0042073)2.69534613
139mitochondrial respiratory chain complex assembly (GO:0033108)2.67018357
140meiotic chromosome segregation (GO:0045132)2.64706143
141establishment of protein localization to mitochondrion (GO:0072655)2.64610674
142axoneme assembly (GO:0035082)2.63213356
143regulation of integrin activation (GO:0033623)2.62566635
144transcription elongation from RNA polymerase III promoter (GO:0006385)2.62205339
145termination of RNA polymerase III transcription (GO:0006386)2.62205339
146serotonin receptor signaling pathway (GO:0007210)2.61916589
147establishment of monopolar cell polarity (GO:0061162)2.60060354
148establishment or maintenance of monopolar cell polarity (GO:0061339)2.60060354
149regulation of respiratory gaseous exchange (GO:0043576)2.59936453
150metallo-sulfur cluster assembly (GO:0031163)2.58040275
151iron-sulfur cluster assembly (GO:0016226)2.58040275
152face development (GO:0060324)2.57620554
153base-excision repair (GO:0006284)2.56941105
154regulation of double-strand break repair via homologous recombination (GO:0010569)2.56799115
155oxidative phosphorylation (GO:0006119)2.52815275
156respiratory chain complex IV assembly (GO:0008535)2.52645255
157DNA dealkylation (GO:0035510)2.51198400
1582-deoxyribonucleotide biosynthetic process (GO:0009265)2.50683660
159deoxyribose phosphate biosynthetic process (GO:0046385)2.50683660
160pseudouridine synthesis (GO:0001522)2.50599091
161regulation of membrane depolarization (GO:0003254)2.49744724
162telomere maintenance via recombination (GO:0000722)2.49733203
1637-methylguanosine mRNA capping (GO:0006370)2.49264607
164transcription-coupled nucleotide-excision repair (GO:0006283)2.48802989
165epithelial cilium movement (GO:0003351)2.47151270
166formation of translation preinitiation complex (GO:0001731)2.45987278
167regulation of cell maturation (GO:1903429)2.44924889
168RNA capping (GO:0036260)2.43862337
1697-methylguanosine RNA capping (GO:0009452)2.43862337
170nonmotile primary cilium assembly (GO:0035058)2.43795930
171double-strand break repair via nonhomologous end joining (GO:0006303)2.42728494
172non-recombinational repair (GO:0000726)2.42728494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.57408961
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.00956419
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95049485
4ZNF274_21170338_ChIP-Seq_K562_Hela2.83635486
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.82508191
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79031506
7THAP11_20581084_ChIP-Seq_MESCs_Mouse2.78779473
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64346163
9YY1_21170310_ChIP-Seq_MESCs_Mouse2.58727984
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.44654618
11EZH2_22144423_ChIP-Seq_EOC_Human2.37560846
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34520854
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33534870
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.31522678
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30866192
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29090243
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.27314874
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.20722301
19GBX2_23144817_ChIP-Seq_PC3_Human2.17431262
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.12296393
21MYC_18940864_ChIP-ChIP_HL60_Human2.11274884
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06642545
23XRN2_22483619_ChIP-Seq_HELA_Human1.82219011
24VDR_22108803_ChIP-Seq_LS180_Human1.82159326
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81860159
26ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79064221
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74631378
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72505671
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71069706
30DCP1A_22483619_ChIP-Seq_HELA_Human1.68783775
31RNF2_27304074_Chip-Seq_NSC_Mouse1.66376745
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65722723
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62367771
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58018934
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56611416
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55610033
37TP53_22573176_ChIP-Seq_HFKS_Human1.54179692
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.50976114
39TTF2_22483619_ChIP-Seq_HELA_Human1.48962070
40IRF1_19129219_ChIP-ChIP_H3396_Human1.48944054
41VDR_23849224_ChIP-Seq_CD4+_Human1.48468789
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48321720
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48105643
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.46618179
45* GABP_19822575_ChIP-Seq_HepG2_Human1.46345390
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45467320
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45467320
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45467320
49REST_21632747_ChIP-Seq_MESCs_Mouse1.43488478
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.41821218
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.41482794
52PU.1_20513432_ChIP-Seq_Bcells_Mouse1.41182005
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41108698
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40611736
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38114938
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37378118
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37102103
58SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36620191
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34997153
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34340825
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33278717
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31623104
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30682465
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30263450
65SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.28788867
66E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26302193
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.25938247
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25880979
69IGF1R_20145208_ChIP-Seq_DFB_Human1.25331113
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24611164
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23670600
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23287773
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.23226504
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22742185
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22349807
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22199553
77ELK1_19687146_ChIP-ChIP_HELA_Human1.21132504
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21005399
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20951592
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20131577
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.18732011
82NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.17219075
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.15949194
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.15021095
85FOXP3_21729870_ChIP-Seq_TREG_Human1.14624853
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12807051
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12603712
88CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11793084
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.11654729
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11585758
91CIITA_25753668_ChIP-Seq_RAJI_Human1.10740840
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09904819
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09020635
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.08413027
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08192298
96* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07883716
97NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07094474
98KDM5A_27292631_Chip-Seq_BREAST_Human1.06992733
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06804496
100NANOG_20526341_ChIP-Seq_ESCs_Human1.06709503
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06343337
102CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06002496
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05619730
104FOXP1_21924763_ChIP-Seq_HESCs_Human1.05066556
105ERA_21632823_ChIP-Seq_H3396_Human1.05062997
106PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04861997
107TP53_20018659_ChIP-ChIP_R1E_Mouse1.04582047
108TAF2_19829295_ChIP-Seq_ESCs_Human1.03678209
109NCOR_22424771_ChIP-Seq_293T_Human1.01534216
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01413463
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01131568
112GATA3_21878914_ChIP-Seq_MCF-7_Human1.00930022
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00190843
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98822616
115P300_18555785_Chip-Seq_ESCs_Mouse0.98299385
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.98260053
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98187659
118AR_20517297_ChIP-Seq_VCAP_Human0.97734741
119BCL6_27268052_Chip-Seq_Bcells_Human0.97595966
120EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97548585
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96572955
122FOXA1_25329375_ChIP-Seq_VCAP_Human0.96497643
123FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96497643
124JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94472103
125EWS_26573619_Chip-Seq_HEK293_Human0.94391265
126STAT1_20625510_ChIP-Seq_HELA_Human0.93354180
127YY1_22570637_ChIP-Seq_MALME-3M_Human0.92751084
128* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92396683
129MYC_19829295_ChIP-Seq_ESCs_Human0.91991151
130POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91820274
131EED_16625203_ChIP-ChIP_MESCs_Mouse0.91126656
132BP1_19119308_ChIP-ChIP_Hs578T_Human0.90967458
133E2F1_18555785_Chip-Seq_ESCs_Mouse0.90513924
134CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90464048
135PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90262960
136FUS_26573619_Chip-Seq_HEK293_Human0.89903648
137MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89215549
138PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88987858
139CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87509781
140HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87426514
141* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87421208
142ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86888698
143KLF4_18555785_Chip-Seq_ESCs_Mouse0.86839441
144TAF15_26573619_Chip-Seq_HEK293_Human0.86188327
145MYCN_18555785_ChIP-Seq_MESCs_Mouse0.86019994
146PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85900173
147NMYC_18555785_Chip-Seq_ESCs_Mouse0.85695275
148SOX2_16153702_ChIP-ChIP_HESCs_Human0.85483476
149CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85199226
150ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84697350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.62451052
2MP0008057_abnormal_DNA_replication3.27816472
3MP0003880_abnormal_central_pattern3.02911169
4MP0001188_hyperpigmentation2.41389781
5MP0002735_abnormal_chemical_nociception2.39373995
6MP0008995_early_reproductive_senescence2.37584033
7MP0005645_abnormal_hypothalamus_physiol2.31138762
8MP0005084_abnormal_gallbladder_morpholo2.28478560
9MP0000015_abnormal_ear_pigmentation2.27912873
10MP0005174_abnormal_tail_pigmentation2.18229779
11MP0004142_abnormal_muscle_tone2.17825280
12MP0006276_abnormal_autonomic_nervous2.17693936
13MP0010030_abnormal_orbit_morphology2.17414851
14MP0003011_delayed_dark_adaptation2.14513020
15MP0006292_abnormal_olfactory_placode2.00318557
16MP0002736_abnormal_nociception_after2.00306556
17MP0002653_abnormal_ependyma_morphology1.98954560
18MP0001986_abnormal_taste_sensitivity1.97136002
19MP0001968_abnormal_touch/_nociception1.93248903
20MP0008058_abnormal_DNA_repair1.89236120
21MP0003136_yellow_coat_color1.88246644
22MP0006072_abnormal_retinal_apoptosis1.80534120
23MP0001529_abnormal_vocalization1.79707390
24MP0001970_abnormal_pain_threshold1.77241234
25MP0009046_muscle_twitch1.77000473
26MP0002733_abnormal_thermal_nociception1.76413074
27MP0002572_abnormal_emotion/affect_behav1.75961298
28MP0002009_preneoplasia1.74659050
29MP0002751_abnormal_autonomic_nervous1.74473722
30MP0003786_premature_aging1.73993220
31MP0002163_abnormal_gland_morphology1.70567071
32MP0005551_abnormal_eye_electrophysiolog1.67097145
33MP0008872_abnormal_physiological_respon1.65081269
34MP0008877_abnormal_DNA_methylation1.58201132
35MP0008875_abnormal_xenobiotic_pharmacok1.58133805
36MP0006036_abnormal_mitochondrial_physio1.54661944
37MP0002064_seizures1.54295872
38MP0003186_abnormal_redox_activity1.54160263
39MP0005075_abnormal_melanosome_morpholog1.52792426
40MP0002822_catalepsy1.49426613
41MP0003121_genomic_imprinting1.48987131
42MP0004147_increased_porphyrin_level1.47787634
43MP0002234_abnormal_pharynx_morphology1.47302049
44MP0002063_abnormal_learning/memory/cond1.46432079
45MP0004133_heterotaxia1.45671569
46MP0003890_abnormal_embryonic-extraembry1.45671560
47MP0002272_abnormal_nervous_system1.42997044
48MP0004742_abnormal_vestibular_system1.42349024
49MP0002160_abnormal_reproductive_system1.40173960
50MP0005646_abnormal_pituitary_gland1.39855431
51MP0002837_dystrophic_cardiac_calcinosis1.39438777
52MP0000778_abnormal_nervous_system1.38004083
53MP0003635_abnormal_synaptic_transmissio1.37047098
54MP0009745_abnormal_behavioral_response1.36805490
55MP0002938_white_spotting1.36804379
56MP0004859_abnormal_synaptic_plasticity1.36481470
57MP0005389_reproductive_system_phenotype1.36377836
58MP0002638_abnormal_pupillary_reflex1.34448698
59MP0002184_abnormal_innervation1.33857708
60MP0002067_abnormal_sensory_capabilities1.30686641
61MP0004233_abnormal_muscle_weight1.30033463
62MP0001905_abnormal_dopamine_level1.29676363
63MP0003806_abnormal_nucleotide_metabolis1.28223552
64MP0005377_hearing/vestibular/ear_phenot1.26928103
65MP0003878_abnormal_ear_physiology1.26928103
66MP0001764_abnormal_homeostasis1.26820431
67MP0005379_endocrine/exocrine_gland_phen1.26257767
68MP0000681_abnormal_thyroid_gland1.23718882
69MP0010386_abnormal_urinary_bladder1.22655119
70MP0002249_abnormal_larynx_morphology1.19336164
71MP0003122_maternal_imprinting1.18557538
72MP0002928_abnormal_bile_duct1.17704053
73MP0008932_abnormal_embryonic_tissue1.17539255
74MP0000955_abnormal_spinal_cord1.17501238
75MP0001485_abnormal_pinna_reflex1.16752415
76MP0003646_muscle_fatigue1.15567616
77MP0002734_abnormal_mechanical_nocicepti1.15511858
78MP0003195_calcinosis1.15101176
79MP0003693_abnormal_embryo_hatching1.14423482
80MP0003941_abnormal_skin_development1.12605401
81MP0001919_abnormal_reproductive_system1.11787059
82MP0006035_abnormal_mitochondrial_morpho1.11692023
83MP0002876_abnormal_thyroid_physiology1.11281862
84MP0004885_abnormal_endolymph1.09392167
85MP0009278_abnormal_bone_marrow1.08754338
86MP0001293_anophthalmia1.06718001
87MP0010094_abnormal_chromosome_stability1.04126610
88MP0004270_analgesia1.02549000
89MP0002132_abnormal_respiratory_system1.02206501
90MP0000049_abnormal_middle_ear1.01251032
91MP0005253_abnormal_eye_physiology1.00015651
92MP0002557_abnormal_social/conspecific_i0.98039399
93MP0008789_abnormal_olfactory_epithelium0.95861881
94MP0001486_abnormal_startle_reflex0.92651976
95MP0003283_abnormal_digestive_organ0.92092068
96MP0003787_abnormal_imprinting0.91820808
97MP0002752_abnormal_somatic_nervous0.90905752
98MP0009379_abnormal_foot_pigmentation0.90897236
99MP0000026_abnormal_inner_ear0.90217562
100MP0002882_abnormal_neuron_morphology0.89041266
101MP0005386_behavior/neurological_phenoty0.88598914
102MP0004924_abnormal_behavior0.88598914
103MP0000516_abnormal_urinary_system0.88309409
104MP0005367_renal/urinary_system_phenotyp0.88309409
105MP0003718_maternal_effect0.87495207
106MP0003119_abnormal_digestive_system0.86297245
107MP0004134_abnormal_chest_morphology0.86233300
108MP0001324_abnormal_eye_pigmentation0.85687501
109MP0005671_abnormal_response_to0.83945136
110MP0002066_abnormal_motor_capabilities/c0.83788127
111MP0002210_abnormal_sex_determination0.83246135
112MP0000566_synostosis0.82339121
113MP0004811_abnormal_neuron_physiology0.82096440
114MP0005195_abnormal_posterior_eye0.81040502
115MP0001501_abnormal_sleep_pattern0.80716650
116MP0001502_abnormal_circadian_rhythm0.80636610
117MP0005394_taste/olfaction_phenotype0.80481969
118MP0005499_abnormal_olfactory_system0.80481969
119MP0003137_abnormal_impulse_conducting0.80103942
120MP0001963_abnormal_hearing_physiology0.79082386
121MP0009764_decreased_sensitivity_to0.78159902
122MP0000538_abnormal_urinary_bladder0.77945298
123MP0008007_abnormal_cellular_replicative0.77913736
124MP0005410_abnormal_fertilization0.77550807
125MP0000631_abnormal_neuroendocrine_gland0.76788812
126MP0000639_abnormal_adrenal_gland0.76624713
127MP0003828_pulmonary_edema0.76214882
128MP0000372_irregular_coat_pigmentation0.76178302
129MP0002282_abnormal_trachea_morphology0.75771340
130MP0003252_abnormal_bile_duct0.74386145
131MP0004043_abnormal_pH_regulation0.74218573
132MP0005423_abnormal_somatic_nervous0.73279480
133MP0001440_abnormal_grooming_behavior0.73159347
134MP0000470_abnormal_stomach_morphology0.72478823
135MP0001186_pigmentation_phenotype0.71632571
136MP0002095_abnormal_skin_pigmentation0.71116315
137MP0000462_abnormal_digestive_system0.71075213
138MP0001984_abnormal_olfaction0.70349854
139MP0002114_abnormal_axial_skeleton0.68400992
140MP0002102_abnormal_ear_morphology0.67136607

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)4.80843041
2Hepatic necrosis (HP:0002605)3.74179663
3Acute necrotizing encephalopathy (HP:0006965)3.62019653
43-Methylglutaconic aciduria (HP:0003535)3.60930396
5Febrile seizures (HP:0002373)3.54018302
6Abnormal respiratory epithelium morphology (HP:0012253)3.50306029
7Abnormal respiratory motile cilium morphology (HP:0005938)3.50306029
8Concave nail (HP:0001598)3.47872055
9Increased hepatocellular lipid droplets (HP:0006565)3.42840791
10Lipid accumulation in hepatocytes (HP:0006561)3.38951440
11Gait imbalance (HP:0002141)3.37714507
12Medial flaring of the eyebrow (HP:0010747)3.27451452
13Congenital primary aphakia (HP:0007707)3.26402584
14Nephrogenic diabetes insipidus (HP:0009806)3.18278119
15Cerebral edema (HP:0002181)3.18227643
16Abnormality of midbrain morphology (HP:0002418)3.18126921
17Molar tooth sign on MRI (HP:0002419)3.18126921
18Renal Fanconi syndrome (HP:0001994)3.15305042
19Intestinal atresia (HP:0011100)3.05883790
20Abnormal mitochondria in muscle tissue (HP:0008316)3.05609977
21Increased intramyocellular lipid droplets (HP:0012240)3.03265817
22Mitochondrial inheritance (HP:0001427)3.00008997
23Epileptic encephalopathy (HP:0200134)2.99999336
24Atonic seizures (HP:0010819)2.98869945
25Rectal fistula (HP:0100590)2.98593578
26Rectovaginal fistula (HP:0000143)2.98593578
27Lactic acidosis (HP:0003128)2.97064388
28Focal motor seizures (HP:0011153)2.90047654
29Progressive macrocephaly (HP:0004481)2.87467679
30Congenital stationary night blindness (HP:0007642)2.84762063
31Dysautonomia (HP:0002459)2.74148468
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74009750
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74009750
34Nephronophthisis (HP:0000090)2.69789809
35Rib fusion (HP:0000902)2.69672459
36Increased muscle lipid content (HP:0009058)2.68118766
37Abnormal number of erythroid precursors (HP:0012131)2.63267324
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.61722463
39Reticulocytopenia (HP:0001896)2.60692561
40Vaginal atresia (HP:0000148)2.60101731
41Tongue fasciculations (HP:0001308)2.59736323
42Acute encephalopathy (HP:0006846)2.57250856
43Abnormality of cells of the erythroid lineage (HP:0012130)2.57094516
44Myokymia (HP:0002411)2.55110247
45Type 2 muscle fiber atrophy (HP:0003554)2.54826140
46Genital tract atresia (HP:0001827)2.54603617
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53399657
48Abnormality of alanine metabolism (HP:0010916)2.53399657
49Hyperalaninemia (HP:0003348)2.53399657
50Median cleft lip (HP:0000161)2.50880063
51Increased CSF lactate (HP:0002490)2.49009388
52Poor suck (HP:0002033)2.45693848
53Intestinal fistula (HP:0100819)2.45469757
54Abnormal protein glycosylation (HP:0012346)2.44787107
55Abnormal glycosylation (HP:0012345)2.44787107
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.44787107
57Abnormal protein N-linked glycosylation (HP:0012347)2.44787107
58Abnormality of male internal genitalia (HP:0000022)2.43826685
59Hypokinesia (HP:0002375)2.42280074
60Facial hemangioma (HP:0000329)2.42212073
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.41143651
62Exertional dyspnea (HP:0002875)2.39549020
63Vaginal fistula (HP:0004320)2.38311658
64Sclerocornea (HP:0000647)2.37677396
65Poor coordination (HP:0002370)2.37417612
66Premature graying of hair (HP:0002216)2.36104775
67Poikiloderma (HP:0001029)2.35057360
68Hyperglycinemia (HP:0002154)2.34154480
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.33541320
70Pustule (HP:0200039)2.30868588
71Respiratory failure (HP:0002878)2.30396524
72Hepatocellular necrosis (HP:0001404)2.30394782
73Muscle fiber atrophy (HP:0100295)2.30044855
74Hypothermia (HP:0002045)2.29622057
75Redundant skin (HP:0001582)2.29617200
76Type II lissencephaly (HP:0007260)2.29352657
77Lethargy (HP:0001254)2.29251582
78Bifid uvula (HP:0000193)2.27815167
79Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24058358
80Abnormal hair whorl (HP:0010721)2.23652597
81Aplasia of the musculature (HP:0100854)2.23541641
82Methylmalonic aciduria (HP:0012120)2.22525495
83Abolished electroretinogram (ERG) (HP:0000550)2.20860578
84Patellar aplasia (HP:0006443)2.20366308
85Elevated erythrocyte sedimentation rate (HP:0003565)2.19908757
86Popliteal pterygium (HP:0009756)2.18158513
87Abnormal rod and cone electroretinograms (HP:0008323)2.16204446
88Annular pancreas (HP:0001734)2.13546516
89Pheochromocytoma (HP:0002666)2.12627769
90Muscle fibrillation (HP:0010546)2.12603412
91Capillary hemangiomas (HP:0005306)2.10805381
92Type I transferrin isoform profile (HP:0003642)2.10302088
93Absent thumb (HP:0009777)2.10218505
94Abnormal hemoglobin (HP:0011902)2.09756317
95Microretrognathia (HP:0000308)2.09235378
96Bile duct proliferation (HP:0001408)2.09217618
97Abnormal biliary tract physiology (HP:0012439)2.09217618
98Progressive microcephaly (HP:0000253)2.08138887
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07242566
100Absent radius (HP:0003974)2.06244856
101Fetal akinesia sequence (HP:0001989)2.06026769
102Optic disc pallor (HP:0000543)2.05871808
103Diminished movement (HP:0002374)2.04292160
104Methylmalonic acidemia (HP:0002912)2.03132643
105Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02491531
106Dicarboxylic aciduria (HP:0003215)2.02491531
107Orthostatic hypotension (HP:0001278)2.02206722
108Pendular nystagmus (HP:0012043)2.02132734
109True hermaphroditism (HP:0010459)2.01250058
110Narrow nasal bridge (HP:0000446)2.01113309
111Abnormal autonomic nervous system physiology (HP:0012332)2.00666252
112Neuroendocrine neoplasm (HP:0100634)2.00414867
113Increased number of teeth (HP:0011069)1.99623182
114Abnormality of the renal medulla (HP:0100957)1.99239422
115Aplasia/Hypoplasia of the patella (HP:0006498)1.99188407
116Opisthotonus (HP:0002179)1.99117174
117Anencephaly (HP:0002323)1.98692441
118Cerebral hypomyelination (HP:0006808)1.97969158
119Absent forearm bone (HP:0003953)1.96066128
120Aplasia involving forearm bones (HP:0009822)1.96066128
121Limb dystonia (HP:0002451)1.95579402
122Pancreatic fibrosis (HP:0100732)1.95480306
123Abnormality of the labia minora (HP:0012880)1.95171813
124Amelogenesis imperfecta (HP:0000705)1.94660953
125Glycosuria (HP:0003076)1.92673942
126Abnormality of urine glucose concentration (HP:0011016)1.92673942
127Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92364215
128Abnormality of the aortic arch (HP:0012303)1.92333783
129Tented upper lip vermilion (HP:0010804)1.92064031
130Dynein arm defect of respiratory motile cilia (HP:0012255)1.91549912
131Absent/shortened dynein arms (HP:0200106)1.91549912
132Respiratory difficulties (HP:0002880)1.91293650
133IgG deficiency (HP:0004315)1.90924953
134CNS demyelination (HP:0007305)1.90625851
135Retinal dysplasia (HP:0007973)1.89505124
136Optic nerve hypoplasia (HP:0000609)1.89371681
137Alacrima (HP:0000522)1.89045981
138Aplasia/Hypoplasia of the spleen (HP:0010451)1.88815685
139Pancytopenia (HP:0001876)1.86687912
140Acute lymphatic leukemia (HP:0006721)1.86548503
141Abnormality of the ileum (HP:0001549)1.85320335
142Emotional lability (HP:0000712)1.85099453
143Aplasia/hypoplasia of the uterus (HP:0008684)1.84906473
144Esotropia (HP:0000565)1.84881635
145Albinism (HP:0001022)1.84747584
146Duplicated collecting system (HP:0000081)1.84228375
147Microvesicular hepatic steatosis (HP:0001414)1.83835145
148Abnormal ciliary motility (HP:0012262)1.83696165
149Decreased lacrimation (HP:0000633)1.83120223
150Aganglionic megacolon (HP:0002251)1.82492936
151Abnormality of the renal collecting system (HP:0004742)1.81954886
152Aplasia/Hypoplasia of the lens (HP:0008063)1.81950221
153Abnormal drinking behavior (HP:0030082)1.81897591
154Polydipsia (HP:0001959)1.81897591
155Short chin (HP:0000331)1.81841916
156Pancreatic cysts (HP:0001737)1.80907867
157Increased serum lactate (HP:0002151)1.80267677
158Osteomalacia (HP:0002749)1.78505166
159Leukodystrophy (HP:0002415)1.78280895
160Failure to thrive in infancy (HP:0001531)1.76978063
161Exercise intolerance (HP:0003546)1.76337167
162Postaxial foot polydactyly (HP:0001830)1.76056957
163Colon cancer (HP:0003003)1.75650108
164Increased serum pyruvate (HP:0003542)1.75069984
165Generalized aminoaciduria (HP:0002909)1.74546899
166Cystic liver disease (HP:0006706)1.73700906
167Hyperglycinuria (HP:0003108)1.71460512
168Delayed CNS myelination (HP:0002188)1.71299927
169Severe combined immunodeficiency (HP:0004430)1.70699403
170Abnormality of renal resorption (HP:0011038)1.70635197
171Occipital encephalocele (HP:0002085)1.69053805
172Attenuation of retinal blood vessels (HP:0007843)1.68486205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.62097346
2CASK3.44617551
3STK163.30768639
4MAPK153.13029902
5VRK22.85294691
6PIM22.80306546
7PINK12.79180243
8MAP3K62.72660669
9MAP3K122.64066086
10ICK2.60630500
11MAP4K22.55321368
12DDR22.53612804
13TRIM282.48704347
14YES12.43728716
15AKT32.29929942
16MAP3K112.24095016
17PRPF4B2.22421995
18SIK32.21574326
19DAPK12.20508329
20UHMK12.18588010
21MATK2.13226472
22KDR2.04416407
23MAP2K72.00782006
24TESK21.93385276
25NUAK11.85997647
26FGR1.84994023
27WNK41.78090404
28FRK1.67283527
29WNK31.67213118
30GRK11.66549130
31TAOK31.61159504
32NME21.51211922
33BMPR1B1.51007257
34CDK81.38357178
35ERBB31.28924307
36CDC71.28907408
37PDK21.28657523
38KIT1.25023929
39TLK11.24261880
40NTRK31.22988587
41PRKD21.16603505
42NME11.15629396
43CSNK1G21.10762116
44INSRR1.10037011
45DYRK21.03654466
46FLT31.00408930
47SRPK11.00295804
48BCR0.97906580
49MINK10.97504290
50BUB10.95547511
51TNIK0.95052099
52CSNK1A1L0.94077102
53BMPR20.93941979
54PLK40.93574677
55TRPM70.92993970
56GRK60.92946061
57TNK20.90662419
58RPS6KC10.89915886
59RPS6KL10.89915886
60LIMK10.89327756
61CDK70.88477764
62CDK190.87153827
63TXK0.86012311
64CHEK20.85635724
65PLK20.85389006
66ACVR1B0.85191294
67MUSK0.84572230
68TESK10.84161039
69MARK10.83234495
70CSK0.83110887
71MAPK130.81475585
72ADRBK20.81242061
73RPS6KA50.80769916
74OXSR10.79936770
75GRK70.78805495
76CAMK2B0.78197275
77TAOK20.77024586
78CAMKK20.76540575
79PASK0.76377440
80MAPKAPK30.76181586
81MAPKAPK50.75675938
82ZAK0.75674737
83CDC42BPA0.75294012
84MYLK0.74177938
85DAPK20.74104837
86DYRK30.73606154
87PIM10.72068177
88ABL20.72026160
89CAMK2A0.71167294
90ATR0.70603817
91RPS6KA60.69785107
92GRK50.65023621
93TYRO30.64960783
94DYRK1B0.63264560
95CCNB10.63015605
96PLK30.62796441
97PBK0.61752162
98ARAF0.61523111
99VRK10.61374431
100MKNK20.61309679
101PHKG10.61149643
102PHKG20.61149643
103BRAF0.59964609
104EIF2AK20.58047183
105RPS6KB10.57872341
106CAMK2G0.57588256
107LATS20.57236740
108PRKCQ0.57223711
109IKBKB0.56601873
110PRKCI0.56070528
111PRKCE0.53861767
112AURKA0.52655392
113MAP2K60.52503017
114TIE10.51266666
115CAMK2D0.50258041
116WEE10.50029115
117IRAK40.49768476
118LYN0.49487583
119CSNK2A10.49058553
120BLK0.48059987
121EIF2AK10.47358369
122STK390.45869324
123AURKB0.44982569
124PLK10.44280543
125ADRBK10.44082089
126BRSK10.43368352
127MAP2K20.42586456
128SGK20.42416262
129LRRK20.42128537
130PRKACA0.41948372
131CSNK1A10.41644083
132SGK2230.41133563
133SGK4940.41133563
134MKNK10.41113303
135CDK180.39974033
136CSNK2A20.38999878
137PKN10.38987380
138EPHA40.38270495
139CSNK1G10.37403482
140CSNK1G30.37125418
141DAPK30.36883390
142EIF2AK30.36268189
143RAF10.35740522
144SIK20.35087788
145PRKCA0.34999431
146MAP3K40.34786939
147RPS6KA40.34682581
148NEK60.34592795
149MAP3K140.34192100
150MAPK40.33754576
151PRKCG0.33573568
152STK38L0.33286688
153CDK11A0.32845946

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.45119282
2Mismatch repair_Homo sapiens_hsa034303.37169935
3Base excision repair_Homo sapiens_hsa034103.08877404
4Parkinsons disease_Homo sapiens_hsa050122.87665365
5Proteasome_Homo sapiens_hsa030502.81112716
6DNA replication_Homo sapiens_hsa030302.44129696
7Nucleotide excision repair_Homo sapiens_hsa034202.34348876
8RNA polymerase_Homo sapiens_hsa030202.25860024
9Huntingtons disease_Homo sapiens_hsa050162.17268716
10Ribosome_Homo sapiens_hsa030102.11829906
11Collecting duct acid secretion_Homo sapiens_hsa049661.99042024
12Alzheimers disease_Homo sapiens_hsa050101.98898209
13Fanconi anemia pathway_Homo sapiens_hsa034601.96252117
14Protein export_Homo sapiens_hsa030601.95949021
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95591722
16Nicotine addiction_Homo sapiens_hsa050331.89106532
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88590368
18Homologous recombination_Homo sapiens_hsa034401.84703940
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84510137
20Synaptic vesicle cycle_Homo sapiens_hsa047211.76145638
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73337931
22Spliceosome_Homo sapiens_hsa030401.71833999
23Basal transcription factors_Homo sapiens_hsa030221.52479829
24Peroxisome_Homo sapiens_hsa041461.49929325
25Fatty acid biosynthesis_Homo sapiens_hsa000611.44957382
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43497863
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40471768
28Pyrimidine metabolism_Homo sapiens_hsa002401.40380831
29Taste transduction_Homo sapiens_hsa047421.32245147
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27719350
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26470556
32Vibrio cholerae infection_Homo sapiens_hsa051101.25028025
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24958987
34Phototransduction_Homo sapiens_hsa047441.23467809
35Cardiac muscle contraction_Homo sapiens_hsa042601.22659167
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13465063
37Serotonergic synapse_Homo sapiens_hsa047261.10113045
38One carbon pool by folate_Homo sapiens_hsa006701.09433919
39Butanoate metabolism_Homo sapiens_hsa006501.08501228
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07881063
41Primary immunodeficiency_Homo sapiens_hsa053401.07858577
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.07098159
43Propanoate metabolism_Homo sapiens_hsa006401.07031428
44Nitrogen metabolism_Homo sapiens_hsa009101.05585850
45RNA transport_Homo sapiens_hsa030131.03326118
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03009037
47mRNA surveillance pathway_Homo sapiens_hsa030151.01815698
48Selenocompound metabolism_Homo sapiens_hsa004501.00790963
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99085136
50Linoleic acid metabolism_Homo sapiens_hsa005910.96212514
51GABAergic synapse_Homo sapiens_hsa047270.95022651
52Hedgehog signaling pathway_Homo sapiens_hsa043400.94786234
53Circadian rhythm_Homo sapiens_hsa047100.94293089
54Sulfur metabolism_Homo sapiens_hsa009200.93937600
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93918382
56Morphine addiction_Homo sapiens_hsa050320.92204461
57Olfactory transduction_Homo sapiens_hsa047400.88068032
58Tryptophan metabolism_Homo sapiens_hsa003800.88057974
59Rheumatoid arthritis_Homo sapiens_hsa053230.87758439
60RNA degradation_Homo sapiens_hsa030180.86265000
61Purine metabolism_Homo sapiens_hsa002300.85944077
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85114975
63Cell cycle_Homo sapiens_hsa041100.82683216
64Pyruvate metabolism_Homo sapiens_hsa006200.78038714
65Caffeine metabolism_Homo sapiens_hsa002320.76890419
66Glutathione metabolism_Homo sapiens_hsa004800.75765439
67Phagosome_Homo sapiens_hsa041450.75719583
68Amphetamine addiction_Homo sapiens_hsa050310.74659847
69Fatty acid elongation_Homo sapiens_hsa000620.74085192
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.73639789
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73011210
72Wnt signaling pathway_Homo sapiens_hsa043100.71145541
73Allograft rejection_Homo sapiens_hsa053300.70993481
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70570834
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69976231
76Type I diabetes mellitus_Homo sapiens_hsa049400.69301811
77Circadian entrainment_Homo sapiens_hsa047130.68587635
78Ether lipid metabolism_Homo sapiens_hsa005650.68501971
79p53 signaling pathway_Homo sapiens_hsa041150.68169524
80Chemical carcinogenesis_Homo sapiens_hsa052040.67360555
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67207569
82Oocyte meiosis_Homo sapiens_hsa041140.65682157
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64395319
84Autoimmune thyroid disease_Homo sapiens_hsa053200.63349651
85Arginine and proline metabolism_Homo sapiens_hsa003300.63054333
86Dopaminergic synapse_Homo sapiens_hsa047280.63048269
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62695322
88Shigellosis_Homo sapiens_hsa051310.62493049
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61493045
90Glutamatergic synapse_Homo sapiens_hsa047240.61120959
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59769093
92Regulation of autophagy_Homo sapiens_hsa041400.58598601
93Hippo signaling pathway_Homo sapiens_hsa043900.57698525
94Long-term depression_Homo sapiens_hsa047300.57431660
95Steroid biosynthesis_Homo sapiens_hsa001000.55869751
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55866440
97Sulfur relay system_Homo sapiens_hsa041220.55060318
98Graft-versus-host disease_Homo sapiens_hsa053320.52815964
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52795927
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51155410
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51129553
102Gap junction_Homo sapiens_hsa045400.50886960
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50076079
104Epstein-Barr virus infection_Homo sapiens_hsa051690.49700402
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47884396
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45074129
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44907735
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43350571
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.42798772
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42390970
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42376142
112beta-Alanine metabolism_Homo sapiens_hsa004100.41482193
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40626534
114Arachidonic acid metabolism_Homo sapiens_hsa005900.40258150
115Calcium signaling pathway_Homo sapiens_hsa040200.40221260
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39734025
117ErbB signaling pathway_Homo sapiens_hsa040120.38948417
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38252497
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.36723488
120Fructose and mannose metabolism_Homo sapiens_hsa000510.36171666
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35665445
122Insulin secretion_Homo sapiens_hsa049110.34870669
123Biosynthesis of amino acids_Homo sapiens_hsa012300.34663552
124Retinol metabolism_Homo sapiens_hsa008300.34222369
125Metabolic pathways_Homo sapiens_hsa011000.33510504
126Tyrosine metabolism_Homo sapiens_hsa003500.32568868
127Basal cell carcinoma_Homo sapiens_hsa052170.32206817
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.32151200
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.30519682
130Non-homologous end-joining_Homo sapiens_hsa034500.30485431
131Folate biosynthesis_Homo sapiens_hsa007900.29459564
132Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29142770
133Fat digestion and absorption_Homo sapiens_hsa049750.28728349
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.28482796
135Notch signaling pathway_Homo sapiens_hsa043300.28408847
136MAPK signaling pathway_Homo sapiens_hsa040100.28388235
137Fatty acid degradation_Homo sapiens_hsa000710.27723163
138Long-term potentiation_Homo sapiens_hsa047200.27526275
139Carbon metabolism_Homo sapiens_hsa012000.26885954
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26420528
141Asthma_Homo sapiens_hsa053100.24929321

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