ARL14EP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an effector protein. It interacts with ADP-ribosylation factor-like 14 [ARL14, also known as ADP-ribosylation factor 7 (ARF7)], beta-actin (ACTB) and actin-based motor protein myosin 1E (MYO1E). ARL14 is a small GTPase; it controls the export of major histocompatibility class II molecules by connecting to the actin network via this effector protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cullin deneddylation (GO:0010388)4.80600819
2protein deneddylation (GO:0000338)4.42207085
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.10068220
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.04115047
5mitochondrial respiratory chain complex assembly (GO:0033108)3.93438038
6nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.88841552
7protein complex biogenesis (GO:0070271)3.81832979
8exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.79601187
9protein neddylation (GO:0045116)3.77468572
10negative regulation of dendrite morphogenesis (GO:0050774)3.67639684
11proteasome assembly (GO:0043248)3.66780798
12DNA double-strand break processing (GO:0000729)3.66264451
13water-soluble vitamin biosynthetic process (GO:0042364)3.66149694
14DNA deamination (GO:0045006)3.66044744
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.63405712
16ATP synthesis coupled proton transport (GO:0015986)3.63405712
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57166115
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.57166115
19NADH dehydrogenase complex assembly (GO:0010257)3.57166115
20viral mRNA export from host cell nucleus (GO:0046784)3.55310788
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.53242366
22cell differentiation involved in metanephros development (GO:0072202)3.47819065
23negative regulation of DNA-dependent DNA replication (GO:2000104)3.46843550
24chaperone-mediated protein transport (GO:0072321)3.42585764
25RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.42151768
26inositol phosphate catabolic process (GO:0071545)3.41736256
27rRNA modification (GO:0000154)3.41481926
28regulation of mitotic spindle checkpoint (GO:1903504)3.40408751
29regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.40408751
30histone H2A acetylation (GO:0043968)3.38590659
31respiratory chain complex IV assembly (GO:0008535)3.36428015
32respiratory electron transport chain (GO:0022904)3.28952944
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.27326503
34electron transport chain (GO:0022900)3.27024569
35metanephric mesenchyme development (GO:0072075)3.27005916
36negative regulation of DNA repair (GO:0045738)3.26957720
37transcription from mitochondrial promoter (GO:0006390)3.25895849
38purine nucleobase biosynthetic process (GO:0009113)3.24043718
39intraciliary transport (GO:0042073)3.17149851
407-methylguanosine mRNA capping (GO:0006370)3.12609432
41viral protein processing (GO:0019082)3.11203064
42microtubule depolymerization (GO:0007019)3.10523368
43organelle disassembly (GO:1903008)3.09910957
44rRNA methylation (GO:0031167)3.08106645
457-methylguanosine RNA capping (GO:0009452)3.07111763
46RNA capping (GO:0036260)3.07111763
47ubiquinone biosynthetic process (GO:0006744)3.07012740
48CENP-A containing nucleosome assembly (GO:0034080)3.03449258
49termination of RNA polymerase III transcription (GO:0006386)3.02031437
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.02031437
51nucleobase biosynthetic process (GO:0046112)3.01817702
52ribonucleoprotein complex disassembly (GO:0032988)3.00116422
53somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99254678
54somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99254678
55isotype switching (GO:0045190)2.99254678
56intracellular protein transmembrane import (GO:0044743)2.98940279
57kidney mesenchyme development (GO:0072074)2.98839652
58chondrocyte proliferation (GO:0035988)2.97444037
59mitotic metaphase plate congression (GO:0007080)2.97371506
60cytochrome complex assembly (GO:0017004)2.96998891
61protein K6-linked ubiquitination (GO:0085020)2.93835227
62ubiquinone metabolic process (GO:0006743)2.93686160
63maturation of 5.8S rRNA (GO:0000460)2.91542037
64positive regulation of mitochondrial fission (GO:0090141)2.89549949
65regulation of meiosis I (GO:0060631)2.88116595
66ribosome assembly (GO:0042255)2.85575966
67establishment of chromosome localization (GO:0051303)2.85331022
68histone mRNA metabolic process (GO:0008334)2.85319948
69mesenchymal cell differentiation involved in renal system development (GO:2001012)2.85079679
70mesenchymal cell differentiation involved in kidney development (GO:0072161)2.85079679
71mitotic sister chromatid segregation (GO:0000070)2.84103613
72snRNA processing (GO:0016180)2.83629436
73chromatin remodeling at centromere (GO:0031055)2.83004989
74positive regulation of male gonad development (GO:2000020)2.82706650
75ether lipid metabolic process (GO:0046485)2.81975276
76IMP biosynthetic process (GO:0006188)2.81829220
77regulation of mitochondrial translation (GO:0070129)2.80669651
78DNA damage response, detection of DNA damage (GO:0042769)2.79473434
79mitochondrial RNA metabolic process (GO:0000959)2.79417715
80metaphase plate congression (GO:0051310)2.78086747
81piRNA metabolic process (GO:0034587)2.76495456
82regulation of male gonad development (GO:2000018)2.75740998
83inositol phosphate dephosphorylation (GO:0046855)2.75161483
84phosphorylated carbohydrate dephosphorylation (GO:0046838)2.75161483
85protein K11-linked deubiquitination (GO:0035871)2.75132004
86negative regulation of mast cell activation (GO:0033004)2.74628079
87rRNA catabolic process (GO:0016075)2.74020897
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73997576
89branched-chain amino acid catabolic process (GO:0009083)2.73959420
90kinetochore organization (GO:0051383)2.72664152
91protein prenylation (GO:0018342)2.72162670
92prenylation (GO:0097354)2.72162670
93DNA catabolic process, exonucleolytic (GO:0000738)2.71665310
94negative regulation of DNA recombination (GO:0045910)2.71199753
95ER overload response (GO:0006983)2.70933555
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70057228
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70057228
98protein-cofactor linkage (GO:0018065)2.69972677
99positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.69316366
100non-recombinational repair (GO:0000726)2.68073198
101double-strand break repair via nonhomologous end joining (GO:0006303)2.68073198
102sister chromatid segregation (GO:0000819)2.67974010
103replication fork processing (GO:0031297)2.66155129
104recombinational repair (GO:0000725)2.65675982
105transcription-coupled nucleotide-excision repair (GO:0006283)2.65271401
106spliceosomal snRNP assembly (GO:0000387)2.64482483
107establishment of integrated proviral latency (GO:0075713)2.64458548
108platelet dense granule organization (GO:0060155)2.64159425
109nuclear pore complex assembly (GO:0051292)2.62840093
110positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62617332
111double-strand break repair via homologous recombination (GO:0000724)2.61447709
112regulation of helicase activity (GO:0051095)2.61096146
113postreplication repair (GO:0006301)2.60421575
114tRNA processing (GO:0008033)2.60039841
115RNA-dependent DNA replication (GO:0006278)2.59072525
116telomere maintenance via semi-conservative replication (GO:0032201)2.55630577
117protein K11-linked ubiquitination (GO:0070979)2.55616983
118multi-organism intracellular transport (GO:1902583)2.55598526
119transport of virus (GO:0046794)2.55598526
120intracellular transport of virus (GO:0075733)2.55598526
121multi-organism transport (GO:0044766)2.55598526
122multi-organism localization (GO:1902579)2.55598526
123L-fucose catabolic process (GO:0042355)2.54955620
124fucose catabolic process (GO:0019317)2.54955620
125L-fucose metabolic process (GO:0042354)2.54955620
126mannosylation (GO:0097502)2.54033158
127retinal cone cell development (GO:0046549)2.53089192
128regulation of DNA endoreduplication (GO:0032875)2.52611465
129transcription initiation from RNA polymerase I promoter (GO:0006361)2.51800878
130regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.50760699
131signal peptide processing (GO:0006465)2.50205978
132ribosomal large subunit biogenesis (GO:0042273)2.49288473
133ncRNA catabolic process (GO:0034661)2.49109291
134spindle checkpoint (GO:0031577)2.48936097
135attachment of spindle microtubules to kinetochore (GO:0008608)2.48923513
136DNA ligation (GO:0006266)2.48687049
137telomere maintenance via recombination (GO:0000722)2.48200008
138single strand break repair (GO:0000012)2.46168096
139nuclear pore organization (GO:0006999)2.45475060
140centriole replication (GO:0007099)2.45210942
141ribosome biogenesis (GO:0042254)2.44967662
142L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44715762
143pore complex assembly (GO:0046931)2.44427264
144mitotic sister chromatid cohesion (GO:0007064)2.44354289
145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.43098828
146GMP metabolic process (GO:0046037)2.42767035
147mismatch repair (GO:0006298)2.42494094
148nucleotide-excision repair, DNA gap filling (GO:0006297)2.42470721
149positive regulation of protein homodimerization activity (GO:0090073)2.42190720
150tRNA metabolic process (GO:0006399)2.42164062
151histone exchange (GO:0043486)2.42101299
152adenosine metabolic process (GO:0046085)2.41908513
153meiotic chromosome segregation (GO:0045132)2.41906148
154mitotic recombination (GO:0006312)2.41375082
155poly(A)+ mRNA export from nucleus (GO:0016973)2.41356224
156sister chromatid cohesion (GO:0007062)2.40938938
157snRNA metabolic process (GO:0016073)2.40432352
158termination of RNA polymerase I transcription (GO:0006363)2.37080996
159protein localization to kinetochore (GO:0034501)2.37027958
160transcription from RNA polymerase I promoter (GO:0006360)2.36276871
161positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.34262755
162negative regulation of sister chromatid segregation (GO:0033046)2.32573464
163negative regulation of mitotic sister chromatid separation (GO:2000816)2.32573464
164negative regulation of mitotic sister chromatid segregation (GO:0033048)2.32573464
165negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.32573464
166deoxyribose phosphate biosynthetic process (GO:0046385)2.32543457
1672-deoxyribonucleotide biosynthetic process (GO:0009265)2.32543457
168negative regulation of stem cell proliferation (GO:2000647)2.32246400
169regulation of sister chromatid segregation (GO:0033045)2.31611519
170regulation of mitotic sister chromatid separation (GO:0010965)2.31611519
171regulation of mitotic sister chromatid segregation (GO:0033047)2.31611519
172transcription elongation from RNA polymerase I promoter (GO:0006362)2.31511955
173regulation of double-strand break repair (GO:2000779)2.31485434
174DNA replication-independent nucleosome organization (GO:0034724)2.31457831
175DNA replication-independent nucleosome assembly (GO:0006336)2.31457831
176neural tube formation (GO:0001841)2.31376589
177mitotic spindle checkpoint (GO:0071174)2.30419833
178regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.30242858
179negative regulation of dendrite development (GO:2000171)2.29790057
180mitotic spindle assembly checkpoint (GO:0007094)2.29653268
181spindle assembly checkpoint (GO:0071173)2.29387891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.73323822
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.02500960
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.96282604
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36117556
5ZNF274_21170338_ChIP-Seq_K562_Hela2.84801565
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.66385322
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55221904
8PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.45344599
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43525991
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.40493966
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38161479
12ELK1_19687146_ChIP-ChIP_HELA_Human2.29016738
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.28355857
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26674357
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25720288
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16275341
17YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16230267
18FUS_26573619_Chip-Seq_HEK293_Human2.15422523
19GBX2_23144817_ChIP-Seq_PC3_Human2.14167181
20IGF1R_20145208_ChIP-Seq_DFB_Human2.13509878
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13046730
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11385318
23EWS_26573619_Chip-Seq_HEK293_Human2.11298718
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06727745
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05686235
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02919195
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.01248689
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00606120
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97033899
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96419099
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95745129
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94226260
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91176319
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.89498374
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82773872
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.79069574
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78255678
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74878262
39TAF15_26573619_Chip-Seq_HEK293_Human1.73135278
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.72241073
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71687436
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70912463
43VDR_23849224_ChIP-Seq_CD4+_Human1.69023230
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68941655
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67867881
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64400915
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63824562
48FOXP3_21729870_ChIP-Seq_TREG_Human1.62525714
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60210813
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56179756
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55188901
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54785125
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.54307834
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.49533760
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.46728509
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46599146
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45881141
58P300_19829295_ChIP-Seq_ESCs_Human1.38325416
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.38070774
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35967994
61CBP_20019798_ChIP-Seq_JUKART_Human1.35967994
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.34138722
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.33361438
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.32518555
65DCP1A_22483619_ChIP-Seq_HELA_Human1.30782708
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27539125
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27238307
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27209141
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26758336
70TP53_22573176_ChIP-Seq_HFKS_Human1.24196621
71RNF2_27304074_Chip-Seq_NSC_Mouse1.23739730
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23636344
73SOX9_26525672_Chip-Seq_HEART_Mouse1.22717562
74IRF1_19129219_ChIP-ChIP_H3396_Human1.22708812
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22452488
76EZH2_22144423_ChIP-Seq_EOC_Human1.22355722
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21486814
78VDR_22108803_ChIP-Seq_LS180_Human1.20480795
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20345202
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19949295
81GABP_19822575_ChIP-Seq_HepG2_Human1.16748072
82NANOG_19829295_ChIP-Seq_ESCs_Human1.16354162
83SOX2_19829295_ChIP-Seq_ESCs_Human1.16354162
84BCAT_22108803_ChIP-Seq_LS180_Human1.14176828
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.13776469
86FOXM1_23109430_ChIP-Seq_U2OS_Human1.13453367
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13341799
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13295561
89ER_23166858_ChIP-Seq_MCF-7_Human1.12264849
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11455723
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10385525
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09994661
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09548873
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09147753
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08866760
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08855504
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08831459
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08789841
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08687312
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.08687312
101YY1_21170310_ChIP-Seq_MESCs_Mouse1.07432421
102TTF2_22483619_ChIP-Seq_HELA_Human1.06673413
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06074418
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05886042
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05851196
106JUN_21703547_ChIP-Seq_K562_Human1.04444664
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02495265
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01044216
109TCF4_22108803_ChIP-Seq_LS180_Human0.99492228
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98567817
111NANOG_16153702_ChIP-ChIP_HESCs_Human0.98438219
112E2F1_18555785_Chip-Seq_ESCs_Mouse0.98244363
113SMAD3_21741376_ChIP-Seq_EPCs_Human0.98242982
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.97906636
115SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97836195
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97686909
117SOX2_16153702_ChIP-ChIP_HESCs_Human0.97492660
118P300_18555785_Chip-Seq_ESCs_Mouse0.97362497
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96725265
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96675656
121TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96279641
122P53_22387025_ChIP-Seq_ESCs_Mouse0.96238541
123TCF4_23295773_ChIP-Seq_U87_Human0.96010479
124OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95916184
125ELK1_22589737_ChIP-Seq_MCF10A_Human0.94633157
126KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94504632
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93916129
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93620500
129STAT3_18555785_Chip-Seq_ESCs_Mouse0.93590590
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93499022
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92735818
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92720296
133SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91238126
134MYC_18940864_ChIP-ChIP_HL60_Human0.91009589
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90512837
136SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90324581
137PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88808891
138SMAD4_21799915_ChIP-Seq_A2780_Human0.87877051
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.86737395
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85718931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.35574874
2MP0001188_hyperpigmentation3.01740960
3MP0003121_genomic_imprinting2.91356125
4MP0003123_paternal_imprinting2.85557456
5MP0006072_abnormal_retinal_apoptosis2.74751864
6MP0003718_maternal_effect2.67132072
7MP0008877_abnormal_DNA_methylation2.57308260
8MP0010094_abnormal_chromosome_stability2.52615602
9MP0003122_maternal_imprinting2.42350009
10MP0000516_abnormal_urinary_system2.38645185
11MP0005367_renal/urinary_system_phenotyp2.38645185
12MP0008007_abnormal_cellular_replicative2.30406392
13MP0005646_abnormal_pituitary_gland2.29587029
14MP0003880_abnormal_central_pattern2.26840099
15MP0008058_abnormal_DNA_repair2.23887762
16MP0008789_abnormal_olfactory_epithelium2.23090659
17MP0005084_abnormal_gallbladder_morpholo2.21910549
18MP0005075_abnormal_melanosome_morpholog2.20310047
19MP0005645_abnormal_hypothalamus_physiol2.19465318
20MP0005503_abnormal_tendon_morphology2.19059346
21MP0003806_abnormal_nucleotide_metabolis2.07721578
22MP0009697_abnormal_copulation2.03291827
23MP0002160_abnormal_reproductive_system2.02017691
24MP0001984_abnormal_olfaction1.97311348
25MP0005253_abnormal_eye_physiology1.93942753
26MP0008057_abnormal_DNA_replication1.80028974
27MP0003942_abnormal_urinary_system1.79191445
28MP0010030_abnormal_orbit_morphology1.78471867
29MP0005394_taste/olfaction_phenotype1.74987969
30MP0005499_abnormal_olfactory_system1.74987969
31MP0000015_abnormal_ear_pigmentation1.69914343
32MP0003077_abnormal_cell_cycle1.69789812
33MP0009250_abnormal_appendicular_skeleto1.69567467
34MP0003693_abnormal_embryo_hatching1.67402263
35MP0008932_abnormal_embryonic_tissue1.67206616
36MP0004142_abnormal_muscle_tone1.62670196
37MP0003111_abnormal_nucleus_morphology1.62499585
38MP0006036_abnormal_mitochondrial_physio1.61936588
39MP0002234_abnormal_pharynx_morphology1.59982956
40MP0000372_irregular_coat_pigmentation1.59875481
41MP0003385_abnormal_body_wall1.59128471
42MP0004957_abnormal_blastocyst_morpholog1.58677539
43MP0006035_abnormal_mitochondrial_morpho1.56602063
44MP0005551_abnormal_eye_electrophysiolog1.52277662
45MP0003646_muscle_fatigue1.51621869
46MP0006292_abnormal_olfactory_placode1.51480552
47MP0002102_abnormal_ear_morphology1.51189557
48MP0005389_reproductive_system_phenotype1.50078958
49MP0002938_white_spotting1.46798132
50MP0001501_abnormal_sleep_pattern1.46535587
51MP0002822_catalepsy1.46405877
52MP0002837_dystrophic_cardiac_calcinosis1.45979055
53MP0002751_abnormal_autonomic_nervous1.45095679
54MP0001919_abnormal_reproductive_system1.43115123
55MP0003755_abnormal_palate_morphology1.41999671
56MP0003315_abnormal_perineum_morphology1.41588930
57MP0005671_abnormal_response_to1.39289204
58MP0010386_abnormal_urinary_bladder1.37822170
59MP0000566_synostosis1.36342766
60MP0004134_abnormal_chest_morphology1.35780123
61MP0005171_absent_coat_pigmentation1.35400253
62MP0008438_abnormal_cutaneous_collagen1.35319437
63MP0000049_abnormal_middle_ear1.32973204
64MP0004215_abnormal_myocardial_fiber1.30850495
65MP0003943_abnormal_hepatobiliary_system1.30651762
66MP0001177_atelectasis1.28776219
67MP0002272_abnormal_nervous_system1.26948881
68MP0009053_abnormal_anal_canal1.26313837
69MP0002638_abnormal_pupillary_reflex1.25149502
70MP0003937_abnormal_limbs/digits/tail_de1.23905421
71MP0002009_preneoplasia1.22605328
72MP0003941_abnormal_skin_development1.22065803
73MP0001293_anophthalmia1.18163153
74MP0009745_abnormal_behavioral_response1.17657372
75MP0002736_abnormal_nociception_after1.17288926
76MP0008872_abnormal_physiological_respon1.16856944
77MP0001119_abnormal_female_reproductive1.16313860
78MP0003786_premature_aging1.13835876
79MP0002109_abnormal_limb_morphology1.10829341
80MP0001764_abnormal_homeostasis1.10624929
81MP0002282_abnormal_trachea_morphology1.09910439
82MP0003186_abnormal_redox_activity1.09040831
83MP0005408_hypopigmentation1.08114102
84MP0002138_abnormal_hepatobiliary_system1.06940854
85MP0001986_abnormal_taste_sensitivity1.06824198
86MP0005409_darkened_coat_color1.06194456
87MP0002928_abnormal_bile_duct1.03853994
88MP0000350_abnormal_cell_proliferation1.02405703
89MP0001542_abnormal_bone_strength1.01670343
90MP0002177_abnormal_outer_ear1.01227775
91MP0002233_abnormal_nose_morphology0.99916101
92MP0002095_abnormal_skin_pigmentation0.99550405
93MP0004147_increased_porphyrin_level0.98704725
94MP0003567_abnormal_fetal_cardiomyocyte0.98247600
95MP0000631_abnormal_neuroendocrine_gland0.98218563
96MP0002876_abnormal_thyroid_physiology0.97715316
97MP0003890_abnormal_embryonic-extraembry0.97300624
98MP0000534_abnormal_ureter_morphology0.96667457
99MP0008875_abnormal_xenobiotic_pharmacok0.95339380
100MP0002116_abnormal_craniofacial_bone0.94025382
101MP0002396_abnormal_hematopoietic_system0.93381139
102MP0004145_abnormal_muscle_electrophysio0.92915693
103MP0002115_abnormal_skeleton_extremities0.91212269
104MP0004808_abnormal_hematopoietic_stem0.90862669
105MP0002249_abnormal_larynx_morphology0.90806390
106MP0006054_spinal_hemorrhage0.90617575
107MP0002210_abnormal_sex_determination0.89956438
108MP0005508_abnormal_skeleton_morphology0.85367681
109MP0003115_abnormal_respiratory_system0.84780737
110MP0002114_abnormal_axial_skeleton0.84728516
111MP0003136_yellow_coat_color0.84697169
112MP0005266_abnormal_metabolism0.84620586
113MP0001929_abnormal_gametogenesis0.82608539
114MP0003011_delayed_dark_adaptation0.82584404
115MP0005391_vision/eye_phenotype0.82276271
116MP0003763_abnormal_thymus_physiology0.81260429
117MP0001286_abnormal_eye_development0.81153668
118MP0000358_abnormal_cell_content/0.81145368
119MP0006276_abnormal_autonomic_nervous0.80848424
120MP0000681_abnormal_thyroid_gland0.80572987
121MP0001697_abnormal_embryo_size0.80472123
122MP0003195_calcinosis0.80409996
123MP0005395_other_phenotype0.79994802
124MP0001186_pigmentation_phenotype0.77484883
125MP0002111_abnormal_tail_morphology0.77398023
126MP0002163_abnormal_gland_morphology0.77216259
127MP0004133_heterotaxia0.76391094
128MP0000432_abnormal_head_morphology0.74639792
129MP0008995_early_reproductive_senescence0.74351630
130MP0002572_abnormal_emotion/affect_behav0.73493695
131MP0001968_abnormal_touch/_nociception0.73174963
132MP0003252_abnormal_bile_duct0.72965267
133MP0001486_abnormal_startle_reflex0.72787185
134MP0003935_abnormal_craniofacial_develop0.72480100
135MP0002184_abnormal_innervation0.72424889
136MP0005174_abnormal_tail_pigmentation0.71786882
137MP0002067_abnormal_sensory_capabilities0.71526502
138MP0002735_abnormal_chemical_nociception0.71170412
139MP0005195_abnormal_posterior_eye0.71168330
140MP0000653_abnormal_sex_gland0.71144236
141MP0003279_aneurysm0.69546389
142MP0000428_abnormal_craniofacial_morphol0.69344978
143MP0001529_abnormal_vocalization0.69050595
144MP0000569_abnormal_digit_pigmentation0.69021665
145MP0005380_embryogenesis_phenotype0.68630082
146MP0001672_abnormal_embryogenesis/_devel0.68630082
147MP0004782_abnormal_surfactant_physiolog0.68300496
148MP0009703_decreased_birth_body0.68074603
149MP0001905_abnormal_dopamine_level0.67927384
150MP0001873_stomach_inflammation0.67691623
151MP0000427_abnormal_hair_cycle0.67612703
152MP0003984_embryonic_growth_retardation0.66737851
153MP0003698_abnormal_male_reproductive0.66446684
154MP0001485_abnormal_pinna_reflex0.66417906
155MP0009046_muscle_twitch0.66192069

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.17749264
2Abnormal mitochondria in muscle tissue (HP:0008316)3.98566907
3Progressive macrocephaly (HP:0004481)3.88733885
4Mitochondrial inheritance (HP:0001427)3.72747448
5Increased hepatocellular lipid droplets (HP:0006565)3.68291852
6Abnormality of incisor morphology (HP:0011063)3.53190944
7Acute encephalopathy (HP:0006846)3.52354721
8Increased CSF lactate (HP:0002490)3.50584017
9True hermaphroditism (HP:0010459)3.42125383
10Lipid accumulation in hepatocytes (HP:0006561)3.33545641
11Congenital primary aphakia (HP:0007707)3.28368954
12Pancreatic fibrosis (HP:0100732)3.25929735
13Gait imbalance (HP:0002141)3.22310323
14Nephrogenic diabetes insipidus (HP:0009806)3.17497012
15Medial flaring of the eyebrow (HP:0010747)3.08020372
16Renal cortical cysts (HP:0000803)3.07342069
17Increased intramyocellular lipid droplets (HP:0012240)3.00050350
18Hepatic necrosis (HP:0002605)2.98353811
19Hypothermia (HP:0002045)2.97455453
20Abnormal hair whorl (HP:0010721)2.92306100
21Poor coordination (HP:0002370)2.90532618
22Hepatocellular necrosis (HP:0001404)2.89707762
23Embryonal renal neoplasm (HP:0011794)2.85094058
24Supernumerary spleens (HP:0009799)2.83676125
25Methylmalonic acidemia (HP:0002912)2.83531263
26Nephroblastoma (Wilms tumor) (HP:0002667)2.82230297
27Thyroid-stimulating hormone excess (HP:0002925)2.81213726
28Irregular epiphyses (HP:0010582)2.79564349
29Deep philtrum (HP:0002002)2.78412998
30Renal Fanconi syndrome (HP:0001994)2.77455451
31Cerebral edema (HP:0002181)2.71237344
32Genital tract atresia (HP:0001827)2.66253362
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63333194
34Abnormality of alanine metabolism (HP:0010916)2.63333194
35Hyperalaninemia (HP:0003348)2.63333194
36Abnormality of the renal cortex (HP:0011035)2.60455566
37Hypoplasia of the fovea (HP:0007750)2.59214625
38Aplasia/Hypoplasia of the fovea (HP:0008060)2.59214625
39Congenital stationary night blindness (HP:0007642)2.57836821
40Colon cancer (HP:0003003)2.53514222
41Vaginal atresia (HP:0000148)2.52291917
42Type I transferrin isoform profile (HP:0003642)2.52005974
43Asymmetry of the thorax (HP:0001555)2.50976455
44Exertional dyspnea (HP:0002875)2.47764811
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.46152865
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.46152865
47Methylmalonic aciduria (HP:0012120)2.45608045
48Abnormality of B cell number (HP:0010975)2.44837424
49Pancreatic cysts (HP:0001737)2.44511883
50Papillary thyroid carcinoma (HP:0002895)2.43579000
51Short tibia (HP:0005736)2.42815662
52Increased serum lactate (HP:0002151)2.42551527
53Spinal cord lesions (HP:0100561)2.41829304
54Syringomyelia (HP:0003396)2.41829304
55Optic disc pallor (HP:0000543)2.40883324
56Abolished electroretinogram (ERG) (HP:0000550)2.39736096
57Adrenal hypoplasia (HP:0000835)2.39394459
58Degeneration of anterior horn cells (HP:0002398)2.39202687
59Abnormality of the anterior horn cell (HP:0006802)2.39202687
60Abnormal lung lobation (HP:0002101)2.38827579
61Vitreoretinal degeneration (HP:0000655)2.37709997
623-Methylglutaconic aciduria (HP:0003535)2.37362683
63Lactic acidosis (HP:0003128)2.36823081
64Abnormality of the fovea (HP:0000493)2.36418110
65Congenital, generalized hypertrichosis (HP:0004540)2.34533293
66Abnormality of the labia minora (HP:0012880)2.34249247
67Increased muscle lipid content (HP:0009058)2.34203731
68Nephronophthisis (HP:0000090)2.33515882
69B lymphocytopenia (HP:0010976)2.31910726
70Abnormal biliary tract physiology (HP:0012439)2.31015020
71Bile duct proliferation (HP:0001408)2.31015020
72Protruding tongue (HP:0010808)2.28616192
73Ectopic kidney (HP:0000086)2.25299971
74Aplasia/Hypoplasia of the tongue (HP:0010295)2.23086722
75Febrile seizures (HP:0002373)2.22856333
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22334699
77Postaxial foot polydactyly (HP:0001830)2.21580851
78Chromsome breakage (HP:0040012)2.20970398
79Abnormality of methionine metabolism (HP:0010901)2.20014129
80Broad foot (HP:0001769)2.18853384
81Preaxial hand polydactyly (HP:0001177)2.17176784
82Flat capital femoral epiphysis (HP:0003370)2.16341782
83Thyroiditis (HP:0100646)2.15072937
84Abnormality of the nasal septum (HP:0000419)2.13775454
85Abnormality of the incisor (HP:0000676)2.13367560
86Neoplasm of the adrenal cortex (HP:0100641)2.11763803
87Mild short stature (HP:0003502)2.11710566
88Thyroid carcinoma (HP:0002890)2.11691029
89Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.09957771
90Absent eyebrow (HP:0002223)2.07990664
91Abnormal rod and cone electroretinograms (HP:0008323)2.07879346
92Aplasia/Hypoplasia of the lens (HP:0008063)2.07797502
93Respiratory failure (HP:0002878)2.06161887
94Abnormality of serum amino acid levels (HP:0003112)2.04297595
95Central scotoma (HP:0000603)2.03909749
96Chronic hepatic failure (HP:0100626)2.03879985
97Leukodystrophy (HP:0002415)2.03065946
98Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01938519
99Attenuation of retinal blood vessels (HP:0007843)2.01467293
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97847590
101Meckel diverticulum (HP:0002245)1.97036425
102Median cleft lip (HP:0000161)1.96424137
103IgM deficiency (HP:0002850)1.96157202
104Respiratory difficulties (HP:0002880)1.96095937
105Exercise intolerance (HP:0003546)1.95269360
106Intestinal atresia (HP:0011100)1.94090516
107Severe combined immunodeficiency (HP:0004430)1.92888419
108Dental crowding (HP:0000678)1.92864428
109Occipital encephalocele (HP:0002085)1.91894139
110Abnormality of the renal medulla (HP:0100957)1.91574377
111Tongue fasciculations (HP:0001308)1.89380544
112Abnormality of midbrain morphology (HP:0002418)1.89328775
113Molar tooth sign on MRI (HP:0002419)1.89328775
114Hyperglycinemia (HP:0002154)1.88642164
115Short foot (HP:0001773)1.86731241
116Glycosuria (HP:0003076)1.86609959
117Abnormality of urine glucose concentration (HP:0011016)1.86609959
118Postaxial hand polydactyly (HP:0001162)1.85225606
119Asplenia (HP:0001746)1.84770097
120Volvulus (HP:0002580)1.82995004
121IgG deficiency (HP:0004315)1.82674111
122Hepatoblastoma (HP:0002884)1.82417664
123Optic nerve hypoplasia (HP:0000609)1.82169935
124Hypoglycemic coma (HP:0001325)1.82151720
125Atonic seizures (HP:0010819)1.81390946
126Abnormality of the ileum (HP:0001549)1.81274939
127Long foot (HP:0001833)1.81146400
128Long clavicles (HP:0000890)1.80901682
129Lethargy (HP:0001254)1.80775198
130Bell-shaped thorax (HP:0001591)1.80435367
131Alveolar cell carcinoma (HP:0006519)1.80200090
132Patellar aplasia (HP:0006443)1.79529675
133Abnormality of macular pigmentation (HP:0008002)1.78511687
134Hypoplastic left heart (HP:0004383)1.77391325
135Abnormality of renal resorption (HP:0011038)1.77207634
136Astigmatism (HP:0000483)1.76774692
137Dandy-Walker malformation (HP:0001305)1.76126093
138Abnormality of the columella (HP:0009929)1.75852107
139Diastasis recti (HP:0001540)1.75543011
140Metaphyseal dysplasia (HP:0100255)1.74688435
141Duodenal stenosis (HP:0100867)1.74673016
142Small intestinal stenosis (HP:0012848)1.74673016
143Hyperventilation (HP:0002883)1.74465383
144Reduced antithrombin III activity (HP:0001976)1.74423820
145Microglossia (HP:0000171)1.74175976
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74065317
147Absent epiphyses (HP:0010577)1.74065317
148Abnormality of chromosome stability (HP:0003220)1.73772663
149Aplasia/hypoplasia of the uterus (HP:0008684)1.73528413
150Aplasia/Hypoplasia of the tibia (HP:0005772)1.73219304
151Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72977877
152Cutaneous melanoma (HP:0012056)1.72967195
153Submucous cleft hard palate (HP:0000176)1.72814836
154Capillary hemangiomas (HP:0005306)1.71878838
155Delayed CNS myelination (HP:0002188)1.71595436
156Aplastic anemia (HP:0001915)1.71442913
157Aplasia/Hypoplasia of the spleen (HP:0010451)1.71155467
158Hypoplastic iliac wings (HP:0002866)1.70858946
159Mesomelia (HP:0003027)1.70174602
160Aplasia/Hypoplasia of the sternum (HP:0006714)1.70117076
161Aplasia/Hypoplasia of the uvula (HP:0010293)1.69854668
162Heterochromia iridis (HP:0001100)1.69550961
163Meningioma (HP:0002858)1.68580686
164Birth length less than 3rd percentile (HP:0003561)1.68207854
165Aganglionic megacolon (HP:0002251)1.67861051
166Abnormality of the intervertebral disk (HP:0005108)1.67430954
167Neoplasm of the adrenal gland (HP:0100631)1.66940999
168Fibular hypoplasia (HP:0003038)1.66867354
169Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.66231234
170Abnormal protein N-linked glycosylation (HP:0012347)1.66231234
171Abnormal protein glycosylation (HP:0012346)1.66231234
172Abnormal glycosylation (HP:0012345)1.66231234
173Aplasia/Hypoplasia of the patella (HP:0006498)1.66179569
174Short middle phalanx of the 5th finger (HP:0004220)1.65967976
175Sloping forehead (HP:0000340)1.64859065
176Chorioretinal coloboma (HP:0000567)1.64702421
177Renal hypoplasia (HP:0000089)1.63246192
178Optic nerve coloboma (HP:0000588)1.63148783
179Facial cleft (HP:0002006)1.62833032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K25.34992802
2AKT34.33460917
3CASK3.99093136
4PRPF4B3.52420028
5ERBB33.26353553
6ZAK2.76091018
7MKNK12.74526033
8PLK22.62345620
9STK38L2.37157241
10TSSK62.36595715
11MKNK22.32574490
12PLK32.31250182
13TAOK32.31173030
14SGK22.26417233
15SRPK12.25307626
16EIF2AK12.19563849
17WNK32.09192943
18MST42.05201635
19FRK2.00266385
20STK241.86134168
21MAP2K71.85805271
22CCNB11.81154438
23SIK31.78232169
24PLK41.78231263
25MAPK131.73492888
26BUB11.72473700
27BRAF1.69259439
28BMPR21.62023168
29PINK11.60542658
30MAP3K121.50025565
31VRK11.48326653
32CDC71.46663413
33YES11.45139897
34BRSK21.40437175
35EIF2AK31.35599880
36CSNK1G11.34742356
37SGK31.30038367
38CSNK1G21.27583912
39NEK61.27190998
40SGK2231.26892257
41SGK4941.26892257
42CDK81.25285185
43TRPM71.20671476
44TRIM281.18117099
45GRK11.16401070
46EIF2AK21.13687884
47DYRK31.12608974
48NUAK11.11710571
49OXSR11.08894924
50INSRR1.08050690
51OBSCN1.05459022
52BCR1.01885842
53WEE11.01706621
54RPS6KB11.01012887
55PASK1.00663649
56CSNK1A1L0.97079111
57MAP3K140.96322574
58TXK0.95077361
59BCKDK0.94825481
60PLK10.91271345
61STK160.90236709
62NEK90.87942656
63PBK0.83690407
64ACVR1B0.83431491
65ATR0.81790496
66VRK20.81071842
67KIT0.76320103
68RPS6KA40.75057277
69TAOK20.74260103
70BRSK10.73506357
71PIM20.71391641
72NEK10.71355724
73CHEK20.69784516
74TGFBR10.68328622
75BMPR1B0.67203480
76DAPK10.66618980
77SCYL20.63745362
78RPS6KA20.61154929
79FLT30.60888509
80MAP3K40.60571047
81MYLK0.59488992
82PAK30.59211763
83LIMK10.58915310
84ATM0.57537300
85CHEK10.57113050
86NLK0.56975266
87WNK40.55843272
88STK390.55038475
89ITK0.54313503
90CDK30.53898905
91TLK10.53324714
92CLK10.53323036
93CAMK2A0.50843346
94RPS6KA50.50759273
95NTRK30.49985443
96RPS6KC10.49894425
97RPS6KL10.49894425
98AURKA0.49863163
99SYK0.49526969
100RPS6KA60.48876307
101MINK10.48215732
102PDK40.47852396
103PDK30.47852396
104PRKCI0.47654495
105AURKB0.47291051
106BRD40.46838695
107MARK10.46796204
108TNK20.46733051
109ADRBK20.45510594
110TIE10.44816221
111NME10.43919922
112CHUK0.42735386
113CSNK2A20.42694650
114CDK190.38890845
115CSNK1A10.38875958
116DDR20.38871338
117CSNK2A10.38750141
118ARAF0.38619512
119PIK3CG0.38506440
120ERBB40.38322016
121PIK3CA0.38195541
122CDK10.38163316
123STK30.38055718
124PRKG10.37763562
125CAMKK20.37667915
126PRKCQ0.37400458
127MATK0.37053993
128PIM10.36831735
129CDK20.35850495
130IRAK10.35642498
131PDK20.35223618
132TAF10.34156695
133TTK0.33668493
134CSNK1E0.33404814
135TEC0.32328830
136TNIK0.31238761
137ADRBK10.30194040
138PRKCG0.29804401
139TESK10.29102411
140ROCK10.28244252
141MAP3K60.27563913
142PRKCE0.27488338
143DYRK20.27063647
144CDK70.26755566
145CSNK1G30.25620906
146DYRK1A0.25542261

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.45792766
2DNA replication_Homo sapiens_hsa030302.99436455
3Non-homologous end-joining_Homo sapiens_hsa034502.77676280
4Mismatch repair_Homo sapiens_hsa034302.74544306
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73163700
6Homologous recombination_Homo sapiens_hsa034402.65542792
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63610497
8Proteasome_Homo sapiens_hsa030502.57743599
9Nucleotide excision repair_Homo sapiens_hsa034202.50732916
10Base excision repair_Homo sapiens_hsa034102.49678005
11RNA polymerase_Homo sapiens_hsa030202.38969092
12Cell cycle_Homo sapiens_hsa041102.35929852
13Basal transcription factors_Homo sapiens_hsa030222.33496507
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26317288
15RNA transport_Homo sapiens_hsa030132.16553290
16Fanconi anemia pathway_Homo sapiens_hsa034602.15499689
17Protein export_Homo sapiens_hsa030602.11914456
18Spliceosome_Homo sapiens_hsa030402.10759358
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07712943
20Ribosome_Homo sapiens_hsa030102.03771356
21Propanoate metabolism_Homo sapiens_hsa006402.01347407
22RNA degradation_Homo sapiens_hsa030181.99833534
23Alzheimers disease_Homo sapiens_hsa050101.88628680
24mRNA surveillance pathway_Homo sapiens_hsa030151.84466353
25One carbon pool by folate_Homo sapiens_hsa006701.80213325
26Olfactory transduction_Homo sapiens_hsa047401.59990577
27Phototransduction_Homo sapiens_hsa047441.57627194
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56894350
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46529678
30Butanoate metabolism_Homo sapiens_hsa006501.43644201
31Primary immunodeficiency_Homo sapiens_hsa053401.38196762
32Pyrimidine metabolism_Homo sapiens_hsa002401.37929417
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35164501
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30979548
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25954717
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.25434611
37Cardiac muscle contraction_Homo sapiens_hsa042601.24534114
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19360831
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.18900512
40Thyroid cancer_Homo sapiens_hsa052161.17375195
41Collecting duct acid secretion_Homo sapiens_hsa049661.17333754
42Purine metabolism_Homo sapiens_hsa002301.17087489
43Synaptic vesicle cycle_Homo sapiens_hsa047211.16692404
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09601527
45Regulation of autophagy_Homo sapiens_hsa041401.07629070
46Epstein-Barr virus infection_Homo sapiens_hsa051691.06899784
47Vibrio cholerae infection_Homo sapiens_hsa051101.06292468
48Oocyte meiosis_Homo sapiens_hsa041141.03990802
49Melanoma_Homo sapiens_hsa052181.00835547
50p53 signaling pathway_Homo sapiens_hsa041151.00226642
51Peroxisome_Homo sapiens_hsa041460.99691751
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96433355
53Endometrial cancer_Homo sapiens_hsa052130.93424351
54N-Glycan biosynthesis_Homo sapiens_hsa005100.90166915
55Nicotine addiction_Homo sapiens_hsa050330.89811933
56Folate biosynthesis_Homo sapiens_hsa007900.88410883
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85256813
58Phagosome_Homo sapiens_hsa041450.84373709
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80753548
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78074401
61Pyruvate metabolism_Homo sapiens_hsa006200.77553925
62Fatty acid elongation_Homo sapiens_hsa000620.76477258
63Caffeine metabolism_Homo sapiens_hsa002320.74088651
64Serotonergic synapse_Homo sapiens_hsa047260.74056738
65Autoimmune thyroid disease_Homo sapiens_hsa053200.73624547
66Alcoholism_Homo sapiens_hsa050340.73460620
67Dopaminergic synapse_Homo sapiens_hsa047280.73262320
68Steroid biosynthesis_Homo sapiens_hsa001000.72853107
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72457645
70Selenocompound metabolism_Homo sapiens_hsa004500.71137051
71Colorectal cancer_Homo sapiens_hsa052100.70898645
72TGF-beta signaling pathway_Homo sapiens_hsa043500.68812347
73Graft-versus-host disease_Homo sapiens_hsa053320.68744148
74Hippo signaling pathway_Homo sapiens_hsa043900.68176269
75Metabolic pathways_Homo sapiens_hsa011000.67555169
76Prostate cancer_Homo sapiens_hsa052150.65520829
77Type I diabetes mellitus_Homo sapiens_hsa049400.64742715
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63932800
79HTLV-I infection_Homo sapiens_hsa051660.62956378
80Huntingtons disease_Homo sapiens_hsa050160.62623922
81Herpes simplex infection_Homo sapiens_hsa051680.62304353
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62255566
83Linoleic acid metabolism_Homo sapiens_hsa005910.62198002
84Wnt signaling pathway_Homo sapiens_hsa043100.61801219
85Viral carcinogenesis_Homo sapiens_hsa052030.61415884
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60635930
87Tryptophan metabolism_Homo sapiens_hsa003800.59651079
88Sulfur metabolism_Homo sapiens_hsa009200.59544233
89Circadian entrainment_Homo sapiens_hsa047130.59104552
90MicroRNAs in cancer_Homo sapiens_hsa052060.59019252
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58759548
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.58390353
93Circadian rhythm_Homo sapiens_hsa047100.58196429
94Rheumatoid arthritis_Homo sapiens_hsa053230.57987361
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56874470
96Basal cell carcinoma_Homo sapiens_hsa052170.56174236
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55610050
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55490566
99Ether lipid metabolism_Homo sapiens_hsa005650.55326647
100Chemical carcinogenesis_Homo sapiens_hsa052040.55109594
101Legionellosis_Homo sapiens_hsa051340.54288852
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53980984
103Long-term potentiation_Homo sapiens_hsa047200.53469917
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53097566
105Allograft rejection_Homo sapiens_hsa053300.52765696
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51647191
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50097201
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49197149
109Nitrogen metabolism_Homo sapiens_hsa009100.49190923
110beta-Alanine metabolism_Homo sapiens_hsa004100.48799551
111Amphetamine addiction_Homo sapiens_hsa050310.48479393
112Morphine addiction_Homo sapiens_hsa050320.46480729
113Hedgehog signaling pathway_Homo sapiens_hsa043400.46191713
114Glutathione metabolism_Homo sapiens_hsa004800.45524553
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45282651
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.45185709
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44287987
118Hepatitis B_Homo sapiens_hsa051610.42388060
119FoxO signaling pathway_Homo sapiens_hsa040680.41962756
120Taste transduction_Homo sapiens_hsa047420.41888158
121Arachidonic acid metabolism_Homo sapiens_hsa005900.41023594
122Measles_Homo sapiens_hsa051620.40035310
123Retinol metabolism_Homo sapiens_hsa008300.40007952
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39418787
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39096792
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.37471410
127Adherens junction_Homo sapiens_hsa045200.37221229
128Pathways in cancer_Homo sapiens_hsa052000.36445719
129Ras signaling pathway_Homo sapiens_hsa040140.36335353
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35960028
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.35295539
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.35267401
133Shigellosis_Homo sapiens_hsa051310.34977498
134Asthma_Homo sapiens_hsa053100.34873836
135Axon guidance_Homo sapiens_hsa043600.34587534
136Influenza A_Homo sapiens_hsa051640.32606565
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32603864
138Antigen processing and presentation_Homo sapiens_hsa046120.31373132
139ErbB signaling pathway_Homo sapiens_hsa040120.29629196
140Long-term depression_Homo sapiens_hsa047300.28244554
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28061270
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28050830
143ECM-receptor interaction_Homo sapiens_hsa045120.26786561
144Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26255748
145Systemic lupus erythematosus_Homo sapiens_hsa053220.26205618
146Parkinsons disease_Homo sapiens_hsa050120.25605616
147GABAergic synapse_Homo sapiens_hsa047270.25598048
148Focal adhesion_Homo sapiens_hsa045100.25257601
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23510680
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22327697

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