ARL13A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.94595821
2sperm-egg recognition (GO:0035036)9.91445397
3acrosome reaction (GO:0007340)9.64329635
4binding of sperm to zona pellucida (GO:0007339)9.26782129
5cell-cell recognition (GO:0009988)8.85752469
6reproduction (GO:0000003)8.78994204
7plasma membrane fusion (GO:0045026)8.64287723
8axonemal dynein complex assembly (GO:0070286)8.43901502
9epithelial cilium movement (GO:0003351)8.42807825
10negative regulation of retinoic acid receptor signaling pathway (GO:0048387)8.33149925
11motile cilium assembly (GO:0044458)8.20596209
12spermatid development (GO:0007286)7.77585360
13regulation of retinoic acid receptor signaling pathway (GO:0048385)7.13530711
14regulation of cilium movement (GO:0003352)6.93454179
15regulation of interleukin-5 production (GO:0032674)6.58708017
16microtubule depolymerization (GO:0007019)6.52202221
17single fertilization (GO:0007338)6.49952895
18cilium movement (GO:0003341)6.42883934
19male meiosis (GO:0007140)6.40088263
20sperm capacitation (GO:0048240)6.26681670
21cilium or flagellum-dependent cell motility (GO:0001539)6.26290639
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.24334411
23synaptonemal complex assembly (GO:0007130)6.11426973
24synaptonemal complex organization (GO:0070193)5.98672906
25centriole replication (GO:0007099)5.89289588
26rRNA methylation (GO:0031167)5.68894669
27fertilization (GO:0009566)5.53592428
28regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)5.39444792
29positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)5.39444792
30spermatogenesis (GO:0007283)5.35128351
31protein targeting to Golgi (GO:0000042)5.34540308
32male gamete generation (GO:0048232)5.34070579
33piRNA metabolic process (GO:0034587)5.33112783
34establishment of protein localization to Golgi (GO:0072600)5.28363163
35retrograde transport, vesicle recycling within Golgi (GO:0000301)5.08691872
36organic cation transport (GO:0015695)5.04261989
37gamete generation (GO:0007276)4.85973872
38sexual reproduction (GO:0019953)4.74388543
39rRNA modification (GO:0000154)4.70179154
40negative regulation of inclusion body assembly (GO:0090084)4.60536001
41calcium ion-dependent exocytosis (GO:0017156)4.57238591
42chromosome organization involved in meiosis (GO:0070192)4.57033209
43microtubule nucleation (GO:0007020)4.51752191
44spermatid nucleus differentiation (GO:0007289)4.51402011
45seminiferous tubule development (GO:0072520)4.49375000
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.41809952
47protein polyglutamylation (GO:0018095)4.40909442
48nuclear pore complex assembly (GO:0051292)4.39225205
49germ cell development (GO:0007281)4.33951441
50cellular response to exogenous dsRNA (GO:0071360)4.31118151
51glycerol ether metabolic process (GO:0006662)4.30937412
52response to pheromone (GO:0019236)4.23989644
53positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.23057602
54regulation of activation of Janus kinase activity (GO:0010533)4.16514099
55cell recognition (GO:0008037)4.10645320
56regulation of microtubule-based movement (GO:0060632)4.07394835
57DNA packaging (GO:0006323)4.04334317
58lactate metabolic process (GO:0006089)4.02321942
59ether metabolic process (GO:0018904)3.96772228
60negative regulation of activin receptor signaling pathway (GO:0032926)3.95653826
61chromosome condensation (GO:0030261)3.93596534
62multicellular organismal reproductive process (GO:0048609)3.82816070
63natural killer cell activation involved in immune response (GO:0002323)3.81798247
64regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.71895612
65receptor recycling (GO:0001881)3.70974163
66regulation of inclusion body assembly (GO:0090083)3.67728771
67protein localization to Golgi apparatus (GO:0034067)3.66684469
68male meiosis I (GO:0007141)3.63774061
69single strand break repair (GO:0000012)3.58236995
70regulation of mesoderm development (GO:2000380)3.56585412
71peptidyl-threonine dephosphorylation (GO:0035970)3.56436362
72DNA methylation involved in gamete generation (GO:0043046)3.53510765
73regulation of centrosome duplication (GO:0010824)3.50736775
74oocyte development (GO:0048599)3.49369693
75nucleus organization (GO:0006997)3.49027655
76ventricular system development (GO:0021591)3.48355921
77detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.48261761
78sequestering of actin monomers (GO:0042989)3.48044568
79regulation of MHC class I biosynthetic process (GO:0045343)3.43328708
80positive regulation of action potential (GO:0045760)3.42280185
81regulation of memory T cell differentiation (GO:0043380)3.37516371
82positive regulation of catecholamine secretion (GO:0033605)3.36910608
83monoubiquitinated protein deubiquitination (GO:0035520)3.36184275
84RNA destabilization (GO:0050779)3.34029385
85histone exchange (GO:0043486)3.32337079
86meiotic nuclear division (GO:0007126)3.29171998
87misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.28130613
88microtubule polymerization or depolymerization (GO:0031109)3.25175471
89genitalia morphogenesis (GO:0035112)3.21464281
90gonadal mesoderm development (GO:0007506)3.21427228
91nuclear pore organization (GO:0006999)3.18078198
92synapsis (GO:0007129)3.17634740
93phosphatidylethanolamine biosynthetic process (GO:0006646)3.16712462
94pore complex assembly (GO:0046931)3.13589561
95pyrimidine-containing compound transmembrane transport (GO:0072531)3.12686578
96protein K11-linked deubiquitination (GO:0035871)3.10905463
97regulation of meiosis I (GO:0060631)3.09241792
98multicellular organismal development (GO:0007275)3.07424864
99response to interferon-beta (GO:0035456)3.02289113
100positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02158213
101left/right pattern formation (GO:0060972)3.00963698
102positive regulation of histone H3-K4 methylation (GO:0051571)2.99508158
103GTP biosynthetic process (GO:0006183)2.96621327
104nucleotide transmembrane transport (GO:1901679)2.95902777
105negative regulation of T cell mediated immunity (GO:0002710)2.95110777
106nephron epithelium morphogenesis (GO:0072088)2.94474418
107nephron tubule morphogenesis (GO:0072078)2.94474418
108positive regulation of T-helper cell differentiation (GO:0045624)2.94381760
109glomerular visceral epithelial cell development (GO:0072015)2.93426339
110regulation of centrosome cycle (GO:0046605)2.92920826
111protein K11-linked ubiquitination (GO:0070979)2.88671180
112negative regulation of viral genome replication (GO:0045071)2.88000465
113regulation of cardioblast differentiation (GO:0051890)2.87346956
114natural killer cell mediated immunity (GO:0002228)2.84079003
115natural killer cell mediated cytotoxicity (GO:0042267)2.84079003
116meiotic cell cycle (GO:0051321)2.84054865
117mitotic sister chromatid cohesion (GO:0007064)2.82578041
118meiosis I (GO:0007127)2.80401033
119phosphatidylethanolamine metabolic process (GO:0046337)2.79757808
120detection of chemical stimulus involved in sensory perception (GO:0050907)2.79681377
121intra-Golgi vesicle-mediated transport (GO:0006891)2.78067709
122Golgi to endosome transport (GO:0006895)2.77565829
123negative regulation by host of viral transcription (GO:0043922)2.77191335
124sensory perception of smell (GO:0007608)2.74454194
125positive regulation of alpha-beta T cell proliferation (GO:0046641)2.74283202
126polyol catabolic process (GO:0046174)2.73178685
127alditol metabolic process (GO:0019400)2.72580176
128positive regulation of Rab GTPase activity (GO:0032851)2.70719698
129regulation of Rab GTPase activity (GO:0032313)2.70719698
130cellular response to heat (GO:0034605)2.70234158
131glomerular epithelial cell development (GO:0072310)2.70046455
132cellular response to interferon-beta (GO:0035458)2.69099685
133positive regulation of T-helper 1 type immune response (GO:0002827)2.68591704
134histone lysine methylation (GO:0034968)2.67557803
135resolution of meiotic recombination intermediates (GO:0000712)2.64664825
136response to misfolded protein (GO:0051788)2.64077010
137response to peptidoglycan (GO:0032494)2.63641403
138muscle organ morphogenesis (GO:0048644)2.63052629
139valine metabolic process (GO:0006573)2.62840847
140DNA replication initiation (GO:0006270)2.61888184
141positive regulation of interleukin-17 production (GO:0032740)2.60084392
142positive regulation of T cell mediated cytotoxicity (GO:0001916)2.59508932
143UTP biosynthetic process (GO:0006228)2.57480577
144chaperone-mediated protein complex assembly (GO:0051131)2.54672054
145centriole assembly (GO:0098534)2.53607130
146UTP metabolic process (GO:0046051)2.52101652
147copper ion homeostasis (GO:0055070)2.51557216
148glycolytic process (GO:0006096)2.51261243
149microtubule severing (GO:0051013)2.50607049
150regulation of centriole replication (GO:0046599)2.47947048
151nucleoside diphosphate phosphorylation (GO:0006165)2.47323913
152sperm motility (GO:0030317)12.0776525
153acrosome assembly (GO:0001675)11.6915360
154cell wall macromolecule metabolic process (GO:0044036)11.4586080
155cell wall macromolecule catabolic process (GO:0016998)11.4586080
156fusion of sperm to egg plasma membrane (GO:0007342)11.3257006

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.28610403
2RBPJ_22232070_ChIP-Seq_NCS_Mouse6.37391493
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.74003637
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.54137673
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.27214109
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.54110535
7EZH2_22144423_ChIP-Seq_EOC_Human2.90419384
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.87715139
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.73224034
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.57260890
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.57040878
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.53582482
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36779681
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28908114
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21751405
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.02283128
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95699010
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91519416
19VDR_22108803_ChIP-Seq_LS180_Human1.89164446
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.89146935
21NFE2_27457419_Chip-Seq_LIVER_Mouse1.87657146
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.85921989
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.84406238
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83346937
25RBPJ_21746931_ChIP-Seq_IB4_Human1.83050197
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.76087494
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73857029
28AR_21572438_ChIP-Seq_LNCaP_Human1.73062882
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.72980607
30STAT3_23295773_ChIP-Seq_U87_Human1.72669369
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.72230342
32SCL_19346495_ChIP-Seq_HPC-7_Human1.68632282
33EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68554993
34TBL1_22424771_ChIP-Seq_293T_Human1.66714080
35STAT1_17558387_ChIP-Seq_HELA_Human1.66521490
36ETV1_20927104_ChIP-Seq_GIST48_Human1.66486583
37SMAD4_21741376_ChIP-Seq_EPCs_Human1.65702837
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64713847
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62983499
40GATA1_26923725_Chip-Seq_HPCs_Mouse1.61768719
41NFYB_21822215_ChIP-Seq_K562_Human1.60910397
42KDM2B_26808549_Chip-Seq_REH_Human1.60750557
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59904847
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58308796
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57419697
46CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.56477780
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.55800543
48CBX2_22325352_ChIP-Seq_293T-Rex_Human1.55789800
49PHF8_20622853_ChIP-Seq_HELA_Human1.55619692
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55459196
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54522810
52HNFA_21074721_ChIP-Seq_CACO-2_Human1.52560384
53KAP1_22055183_ChIP-Seq_ESCs_Mouse1.51922907
54PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.50654016
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50102278
56MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47270314
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.46881882
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45366960
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45087436
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44624775
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44450492
62TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.43652747
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.42921157
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.42818483
65TAF15_26573619_Chip-Seq_HEK293_Human1.41483977
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40672652
67SOX2_22085726_ChIP-Seq_NPCs_Mouse1.38923957
68ER_23166858_ChIP-Seq_MCF-7_Human1.38879047
69IRF8_27001747_Chip-Seq_BMDM_Mouse1.38790597
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38321589
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38083780
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37239108
73NFYA_21822215_ChIP-Seq_K562_Human1.36317508
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.35292102
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.34706183
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34411146
77OCT4_18555785_Chip-Seq_ESCs_Mouse1.33953659
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33832340
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33215205
80ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33050297
81P53_22387025_ChIP-Seq_ESCs_Mouse1.32662121
82ERA_21632823_ChIP-Seq_H3396_Human1.32290386
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31898094
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31510609
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.31095234
86ZNF274_21170338_ChIP-Seq_K562_Hela1.30867280
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30032344
88GATA3_21867929_ChIP-Seq_TH1_Mouse1.29511068
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29399163
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28310372
91* TP53_22573176_ChIP-Seq_HFKS_Human1.27290327
92P300_18555785_Chip-Seq_ESCs_Mouse1.26518448
93GF1_26923725_Chip-Seq_HPCs_Mouse1.25890981
94GATA6_21074721_ChIP-Seq_CACO-2_Human1.25782587
95GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.25081649
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24901882
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.24775385
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.24772461
99SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23584097
100P300_19829295_ChIP-Seq_ESCs_Human1.23393476
101SMAD4_21741376_ChIP-Seq_HESCs_Human1.23161770
102SMAD4_21799915_ChIP-Seq_A2780_Human1.23020267
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22158714
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22158714
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22063229
106ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22055461
107GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.21014975
108IRF1_19129219_ChIP-ChIP_H3396_Human1.20576267
109TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20252720
110PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19827997
111SOX2_18555785_Chip-Seq_ESCs_Mouse1.18588010
112GATA3_21867929_ChIP-Seq_CD8_Mouse1.16120166
113GABP_17652178_ChIP-ChIP_JURKAT_Human1.14535374
114NMYC_18555785_Chip-Seq_ESCs_Mouse1.14354436
115NANOG_19829295_ChIP-Seq_ESCs_Human1.13749003
116SOX2_19829295_ChIP-Seq_ESCs_Human1.13749003
117EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13615499
118FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12883504
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12795911
120TCF4_23295773_ChIP-Seq_U87_Human1.12760660
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.12389204
122FUS_26573619_Chip-Seq_HEK293_Human1.12044053
123RUNX2_22187159_ChIP-Seq_PCA_Human1.11596957
124FOXM1_23109430_ChIP-Seq_U2OS_Human1.11329813
125ESRRB_18555785_Chip-Seq_ESCs_Mouse1.10289427
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09572404
127EST1_17652178_ChIP-ChIP_JURKAT_Human1.09452355
128KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.09358101
129KLF4_18555785_Chip-Seq_ESCs_Mouse1.07714560
130E2F7_22180533_ChIP-Seq_HELA_Human1.07067349
131PU1_27457419_Chip-Seq_LIVER_Mouse1.06825451
132FOXH1_21741376_ChIP-Seq_EPCs_Human1.06824032
133WDR5_24793694_ChIP-Seq_LNCAP_Human1.06030940
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05900718
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.05531246
136MYC_19829295_ChIP-Seq_ESCs_Human1.04805150
137* NANOG_20526341_ChIP-Seq_ESCs_Human1.04597330
138GATA3_21878914_ChIP-Seq_MCF-7_Human1.04288254
139GBX2_23144817_ChIP-Seq_PC3_Human1.04055109
140P53_21459846_ChIP-Seq_SAOS-2_Human1.03955525
141CTCF_18555785_Chip-Seq_ESCs_Mouse1.03834296
142RAC3_21632823_ChIP-Seq_H3396_Human1.03593078
143GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03183550
144SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03068972
145HOXB7_26014856_ChIP-Seq_BT474_Human1.02458530
146SMAD3_21741376_ChIP-Seq_HESCs_Human1.02368093
147LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01473616
148LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.01414248
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01072083
150RNF2_27304074_Chip-Seq_NSC_Mouse1.00690321
151SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00598904
152SMAD3_21741376_ChIP-Seq_ESCs_Human1.00501949
153LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99554518
154CBP_20019798_ChIP-Seq_JUKART_Human0.98956509
155IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98956509
156STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98386662
157RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98189370
158IRF8_22096565_ChIP-ChIP_GC-B_Human0.98038941
159GATA3_26560356_Chip-Seq_TH1_Human0.96654089
160CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96530541
161ZFX_18555785_Chip-Seq_ESCs_Mouse0.96141899
162ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95873942
163HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95772734
164RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95755493
165CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94703895
166SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94526061
167AR_25329375_ChIP-Seq_VCAP_Human0.94401460
168REST_21632747_ChIP-Seq_MESCs_Mouse0.93980403
169RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93824235
170E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93622578
171ERG_20517297_ChIP-Seq_VCAP_Human0.93529927
172SALL4_22934838_ChIP-ChIP_CD34+_Human0.92638566
173CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92537090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.77236157
2MP0001929_abnormal_gametogenesis4.25410894
3MP0003878_abnormal_ear_physiology4.06073319
4MP0005377_hearing/vestibular/ear_phenot4.06073319
5MP0008877_abnormal_DNA_methylation3.80802299
6MP0006082_CNS_inflammation3.34559945
7MP0003880_abnormal_central_pattern2.67661216
8MP0002210_abnormal_sex_determination2.67136465
9MP0005623_abnormal_meninges_morphology2.51324375
10MP0009697_abnormal_copulation2.49492983
11MP0008995_early_reproductive_senescence2.43965348
12MP0009785_altered_susceptibility_to2.42082594
13MP0002161_abnormal_fertility/fecundity2.36966856
14MP0006292_abnormal_olfactory_placode2.34000259
15MP0004957_abnormal_blastocyst_morpholog2.29580204
16MP0005423_abnormal_somatic_nervous2.28789415
17MP0004147_increased_porphyrin_level2.23749816
18MP0000751_myopathy2.18944378
19MP0008057_abnormal_DNA_replication2.17137538
20MP0001145_abnormal_male_reproductive2.14775171
21MP0002148_abnormal_hypersensitivity_rea2.04999188
22MP0004215_abnormal_myocardial_fiber2.03094698
23MP0005410_abnormal_fertilization13.0401843
24MP0004084_abnormal_cardiac_muscle1.95685063
25MP0002132_abnormal_respiratory_system1.93311224
26MP0004484_altered_response_of1.92569524
27MP0000653_abnormal_sex_gland1.87229340
28MP0002163_abnormal_gland_morphology1.80783930
29MP0005408_hypopigmentation1.79937361
30MP0005025_abnormal_response_to1.73564419
31MP0005000_abnormal_immune_tolerance1.70587576
32MP0001835_abnormal_antigen_presentation1.67011818
33MP0005167_abnormal_blood-brain_barrier1.62013823
34MP0003786_premature_aging1.59305215
35MP0005464_abnormal_platelet_physiology1.50100427
36MP0005394_taste/olfaction_phenotype1.46134657
37MP0005499_abnormal_olfactory_system1.46134657
38MP0001293_anophthalmia1.41490841
39MP0003724_increased_susceptibility_to1.40542478
40MP0005075_abnormal_melanosome_morpholog1.39272097
41MP0004036_abnormal_muscle_relaxation1.39007340
42MP0003693_abnormal_embryo_hatching1.38196566
43MP0002419_abnormal_innate_immunity1.38028980
44MP0003077_abnormal_cell_cycle1.32726429
45MP0005670_abnormal_white_adipose1.31615227
46MP0010030_abnormal_orbit_morphology1.30818441
47MP0003300_gastrointestinal_ulcer1.30765286
48MP0008789_abnormal_olfactory_epithelium1.29643576
49MP0001485_abnormal_pinna_reflex1.29636363
50MP0008775_abnormal_heart_ventricle1.28471948
51MP0004019_abnormal_vitamin_homeostasis1.27507339
52MP0002723_abnormal_immune_serum1.26942174
53MP0001486_abnormal_startle_reflex1.26935327
54MP0005395_other_phenotype1.26598917
55MP0003436_decreased_susceptibility_to1.26533584
56MP0003936_abnormal_reproductive_system1.24976306
57MP0003718_maternal_effect1.23210900
58MP0001764_abnormal_homeostasis1.21574348
59MP0000015_abnormal_ear_pigmentation1.18964423
60MP0001765_abnormal_ion_homeostasis1.18562413
61MP0008260_abnormal_autophagy1.18249678
62MP0000462_abnormal_digestive_system1.17348446
63MP0008058_abnormal_DNA_repair1.17206498
64MP0002127_abnormal_cardiovascular_syste1.15868358
65MP0002933_joint_inflammation1.14342197
66MP0005397_hematopoietic_system_phenotyp1.12282760
67MP0001545_abnormal_hematopoietic_system1.12282760
68MP0000383_abnormal_hair_follicle1.11973439
69MP0001986_abnormal_taste_sensitivity1.11430406
70MP0005647_abnormal_sex_gland1.11231085
71MP0002168_other_aberrant_phenotype1.10022341
72MP0003690_abnormal_glial_cell1.09252512
73MP0002277_abnormal_respiratory_mucosa1.09002345
74MP0000372_irregular_coat_pigmentation1.08906724
75MP0005380_embryogenesis_phenotype1.08593130
76MP0001672_abnormal_embryogenesis/_devel1.08593130
77MP0003111_abnormal_nucleus_morphology1.06872573
78MP0008469_abnormal_protein_level1.03120906
79MP0001873_stomach_inflammation1.02424366
80MP0003119_abnormal_digestive_system1.02365353
81MP0009115_abnormal_fat_cell1.02005469
82MP0005248_abnormal_Harderian_gland1.01921790
83MP0002452_abnormal_antigen_presenting1.01554346
84MP0003385_abnormal_body_wall1.00698157
85MP0005409_darkened_coat_color1.00655117
86MP0003763_abnormal_thymus_physiology0.99647038
87MP0000749_muscle_degeneration0.98873843
88MP0001800_abnormal_humoral_immune0.98839141
89MP0002006_tumorigenesis0.98701046
90MP0002736_abnormal_nociception_after0.97414037
91MP0010386_abnormal_urinary_bladder0.96762184
92MP0002282_abnormal_trachea_morphology0.96544055
93MP0005636_abnormal_mineral_homeostasis0.96167453
94MP0000678_abnormal_parathyroid_gland0.95178900
95MP0003787_abnormal_imprinting0.94558873
96MP0002269_muscular_atrophy0.93220968
97MP0003011_delayed_dark_adaptation0.93113201
98MP0002420_abnormal_adaptive_immunity0.92358387
99MP0003984_embryonic_growth_retardation0.91244584
100MP0001819_abnormal_immune_cell0.91062773
101MP0002254_reproductive_system_inflammat0.90101420
102MP0003137_abnormal_impulse_conducting0.89746154
103MP0002972_abnormal_cardiac_muscle0.86940905
104MP0005671_abnormal_response_to0.84826063
105MP0001730_embryonic_growth_arrest0.84639708
106MP0002138_abnormal_hepatobiliary_system0.84472609
107MP0006036_abnormal_mitochondrial_physio0.84363631
108MP0001968_abnormal_touch/_nociception0.83170806
109MP0001984_abnormal_olfaction0.82233374
110MP0004808_abnormal_hematopoietic_stem0.82168933
111MP0002088_abnormal_embryonic_growth/wei0.81283055
112MP0009764_decreased_sensitivity_to0.81178362
113MP0010630_abnormal_cardiac_muscle0.80436912
114MP0001697_abnormal_embryo_size0.78801174
115MP0010094_abnormal_chromosome_stability0.77959696
116MP0003699_abnormal_female_reproductive0.77890047
117MP0006138_congestive_heart_failure0.76703846
118MP0001348_abnormal_lacrimal_gland0.76052031
119MP0009278_abnormal_bone_marrow0.75828959
120MP0003448_altered_tumor_morphology0.75317584
121MP0009046_muscle_twitch0.73916047
122MP0002085_abnormal_embryonic_tissue0.73866424
123MP0005330_cardiomyopathy0.73688527
124MP0000266_abnormal_heart_morphology0.70088581
125MP0004085_abnormal_heartbeat0.69763871
126MP0005084_abnormal_gallbladder_morpholo0.69080770
127MP0009780_abnormal_chondrocyte_physiolo0.68627346
128MP0001845_abnormal_inflammatory_respons0.68366379
129MP0000343_altered_response_to0.68212328
130MP0003935_abnormal_craniofacial_develop0.68207004
131MP0000858_altered_metastatic_potential0.67700165
132MP0005365_abnormal_bile_salt0.65972523
133MP0003195_calcinosis0.65323398
134MP0003075_altered_response_to0.64677688
135MP0006054_spinal_hemorrhage0.64495747
136MP0010368_abnormal_lymphatic_system0.64253042
137MP0005171_absent_coat_pigmentation0.64106806
138MP0009765_abnormal_xenobiotic_induced0.63443351
139MP0000685_abnormal_immune_system0.62587488
140MP0005379_endocrine/exocrine_gland_phen0.62575082
141MP0002398_abnormal_bone_marrow0.62329124
142MP0003868_abnormal_feces_composition0.62290834
143MP0001790_abnormal_immune_system0.61580306
144MP0005387_immune_system_phenotype0.61580306
145MP0000026_abnormal_inner_ear0.61431029
146MP0005646_abnormal_pituitary_gland0.60764072
147MP0002080_prenatal_lethality0.60297157
148MP0000716_abnormal_immune_system0.60191035
149MP0003045_fibrosis0.60090591
150MP0002102_abnormal_ear_morphology0.59828287
151MP0002557_abnormal_social/conspecific_i0.59333276
152MP0002075_abnormal_coat/hair_pigmentati0.58894106
153MP0004782_abnormal_surfactant_physiolog0.58416890
154MP0001963_abnormal_hearing_physiology0.57670083
155MP0001544_abnormal_cardiovascular_syste0.57547073
156MP0003279_aneurysm0.57308854
157MP0003959_abnormal_lean_body0.57082342
158MP0003638_abnormal_response/metabolism_0.57057655
159MP0000613_abnormal_salivary_gland0.55330933
160MP0003646_muscle_fatigue0.53229541
161MP0001119_abnormal_female_reproductive0.52261961
162MP0000689_abnormal_spleen_morphology0.51905293
163MP0005334_abnormal_fat_pad0.51821916
164MP0010155_abnormal_intestine_physiology0.49816848
165MP0005451_abnormal_body_composition0.48413067
166MP0002295_abnormal_pulmonary_circulatio0.47792993
167MP0003866_abnormal_defecation0.47560114
168MP0003633_abnormal_nervous_system0.46170119
169MP0009763_increased_sensitivity_to0.45827738
170MP0002405_respiratory_system_inflammati0.45439799
171MP0002693_abnormal_pancreas_physiology0.45229674
172MP0002429_abnormal_blood_cell0.44437185
173MP0002133_abnormal_respiratory_system0.43097662
174MP0005388_respiratory_system_phenotype0.43097662
175MP0005535_abnormal_body_temperature0.42892452

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)8.60785714
2Abnormal respiratory motile cilium morphology (HP:0005938)7.98642604
3Abnormal respiratory epithelium morphology (HP:0012253)7.98642604
4Abnormal respiratory motile cilium physiology (HP:0012261)7.95860303
5Abnormal ciliary motility (HP:0012262)6.86192657
6Infertility (HP:0000789)5.69596329
7Rhinitis (HP:0012384)5.53615102
8Nasal polyposis (HP:0100582)5.52560188
9Severe visual impairment (HP:0001141)5.24950217
10Bronchiectasis (HP:0002110)4.76360766
11Bronchitis (HP:0012387)4.72073424
12Abnormality of the nasal mucosa (HP:0000433)4.51267423
13Male infertility (HP:0003251)4.31599398
14Abnormal spermatogenesis (HP:0008669)4.04590753
15Genetic anticipation (HP:0003743)4.00153056
16Hypokalemic alkalosis (HP:0001949)3.81448900
17Recurrent sinusitis (HP:0011108)3.54709571
18Abnormality of dental color (HP:0011073)3.40099659
19Amelogenesis imperfecta (HP:0000705)3.33159341
20Progressive cerebellar ataxia (HP:0002073)3.26361312
21Nephronophthisis (HP:0000090)3.18136131
22Hyperactive renin-angiotensin system (HP:0000841)3.05695963
23Abnormality of cochlea (HP:0000375)3.04088251
24Azoospermia (HP:0000027)3.04027628
25Abnormality of the costochondral junction (HP:0000919)3.00897576
26Decreased circulating renin level (HP:0003351)2.94348309
27Attenuation of retinal blood vessels (HP:0007843)2.92621577
28IgM deficiency (HP:0002850)2.87118096
29Abnormality of the aortic arch (HP:0012303)2.85298818
30Slow saccadic eye movements (HP:0000514)2.84735794
31Morphological abnormality of the inner ear (HP:0011390)2.84187635
32Unilateral renal agenesis (HP:0000122)2.83653437
33Abnormality of macular pigmentation (HP:0008002)2.82913485
34Stage 5 chronic kidney disease (HP:0003774)2.81208152
35Short chin (HP:0000331)2.81193232
36Recurrent otitis media (HP:0000403)2.79364356
37Abnormality of glycolysis (HP:0004366)2.76668713
38Hyperaldosteronism (HP:0000859)2.74960462
39Enlarged epiphyses (HP:0010580)2.74117810
40Tubulointerstitial nephritis (HP:0001970)2.71504183
41Subcapsular cataract (HP:0000523)2.70045621
42Molar tooth sign on MRI (HP:0002419)2.68825277
43Abnormality of midbrain morphology (HP:0002418)2.68825277
44Abnormality of chloride homeostasis (HP:0011422)2.67548156
45Bony spicule pigmentary retinopathy (HP:0007737)2.66792153
46Congenital malformation of the right heart (HP:0011723)2.65677340
47Double outlet right ventricle (HP:0001719)2.65677340
48Renal salt wasting (HP:0000127)2.62475838
49Hypoplasia of the thymus (HP:0000778)2.57712471
50Aplasia/Hypoplasia of the earlobes (HP:0009906)2.57485565
51Oligodactyly (hands) (HP:0001180)2.51079140
52Abnormality of the renal medulla (HP:0100957)2.48558483
53Hypobetalipoproteinemia (HP:0003563)2.46031759
54Increased serum pyruvate (HP:0003542)2.44818909
55Asymmetric septal hypertrophy (HP:0001670)2.43750861
56Vascular calcification (HP:0004934)2.41615813
57Hyperkalemia (HP:0002153)2.39486850
58Conjugated hyperbilirubinemia (HP:0002908)2.36792580
59Hypolipoproteinemia (HP:0010981)2.35908311
60Pigmentary retinal degeneration (HP:0001146)2.35516284
61Resting tremor (HP:0002322)2.32785880
62Palpitations (HP:0001962)2.30938606
63Bell-shaped thorax (HP:0001591)2.29007946
64Abnormality of T cell physiology (HP:0011840)2.27952753
65Spinal cord lesions (HP:0100561)2.27508216
66Syringomyelia (HP:0003396)2.27508216
67Optic neuritis (HP:0100653)2.23552564
68Retrobulbar optic neuritis (HP:0100654)2.23552564
69Medial flaring of the eyebrow (HP:0010747)2.22509341
70Hypoalbuminemia (HP:0003073)2.20087641
71Abnormal albumin level (HP:0012116)2.20087641
72Hepatoblastoma (HP:0002884)2.16356522
73Intellectual disability, moderate (HP:0002342)2.15480247
74Absent epiphyses (HP:0010577)2.13248228
75Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.13248228
76Cardiovascular calcification (HP:0011915)2.13237108
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13152218
78Recurrent bronchitis (HP:0002837)2.12931897
79Hypoproteinemia (HP:0003075)2.11978168
80Cervical subluxation (HP:0003308)2.10483068
81Agnosia (HP:0010524)2.10060195
82Cone-rod dystrophy (HP:0000548)2.09985828
83Abnormal rod and cone electroretinograms (HP:0008323)2.08118793
84Mixed hearing impairment (HP:0000410)2.07582966
85Glycosuria (HP:0003076)2.07195799
86Abnormality of urine glucose concentration (HP:0011016)2.07195799
87Tubulointerstitial abnormality (HP:0001969)2.05817000
88Abnormality of DNA repair (HP:0003254)2.04971460
89Orchitis (HP:0100796)2.02521670
90Oligodactyly (HP:0012165)2.02390173
91Pancreatic cysts (HP:0001737)2.00940398
92Dynein arm defect of respiratory motile cilia (HP:0012255)12.5868521
93Absent/shortened dynein arms (HP:0200106)12.5868521
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.1729505
95Abnormality of the right ventricle (HP:0001707)1.99400000
96Renal Fanconi syndrome (HP:0001994)1.96533247
97Renovascular hypertension (HP:0100817)1.96017767
98Urethral obstruction (HP:0000796)1.95234642
99Keratoconjunctivitis sicca (HP:0001097)1.93852195
100Hypoalphalipoproteinemia (HP:0003233)1.92934688
101Widely patent fontanelles and sutures (HP:0004492)1.90625336
102Abnormal delayed hypersensitivity skin test (HP:0002963)1.88966794
103Sandal gap (HP:0001852)1.87255636
104Disproportionate short-trunk short stature (HP:0003521)1.86320739
105Polydipsia (HP:0001959)1.86100710
106Abnormal drinking behavior (HP:0030082)1.86100710
107Aplasia/Hypoplasia involving the musculature (HP:0001460)1.85002117
108Panhypogammaglobulinemia (HP:0003139)1.83790740
109Alkalosis (HP:0001948)1.83754053
110Impulsivity (HP:0100710)1.83437385
111Abnormal glucose tolerance (HP:0001952)1.82432252
112Acute myeloid leukemia (HP:0004808)1.82101607
113Pancreatic fibrosis (HP:0100732)1.80782792
114Macular degeneration (HP:0000608)1.80411740
115Myositis (HP:0100614)1.78636252
116Chronic hepatic failure (HP:0100626)1.77935985
117Ependymoma (HP:0002888)1.77881006
118Abnormality of renal excretion (HP:0011036)1.77877577
119Hypoplastic left heart (HP:0004383)1.77498464
120Poor coordination (HP:0002370)1.76977855
121Occipital encephalocele (HP:0002085)1.75270217
122Scotoma (HP:0000575)1.72370024
123Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.72094832
124Gout (HP:0001997)1.71677825
125Type 2 muscle fiber atrophy (HP:0003554)1.71420761
126Underdeveloped nasal alae (HP:0000430)1.71265380
127Interstitial pulmonary disease (HP:0006530)1.70341218
128Keratoconjunctivitis (HP:0001096)1.70213989
129Hyponatremia (HP:0002902)1.68387837
130Cheilitis (HP:0100825)1.67832319
131Autoimmune hemolytic anemia (HP:0001890)1.67141180
132Nephrogenic diabetes insipidus (HP:0009806)1.59742230
133Nephropathy (HP:0000112)1.59400273
134Absent frontal sinuses (HP:0002688)1.58300058
135Selective tooth agenesis (HP:0001592)1.58049753
136Postaxial foot polydactyly (HP:0001830)1.56104396
137Protuberant abdomen (HP:0001538)1.50793815
138Tubulointerstitial fibrosis (HP:0005576)1.49648921
139Gonadotropin excess (HP:0000837)1.48275523
140Hypothermia (HP:0002045)1.47935000
141Death in childhood (HP:0003819)1.46338760
142Abnormality of renal resorption (HP:0011038)1.45084886
143Pulmonary infiltrates (HP:0002113)1.45077600
144Abnormality of the dental root (HP:0006486)1.44304779
145Taurodontia (HP:0000679)1.44304779
146Abnormality of permanent molar morphology (HP:0011071)1.44304779
147Abnormal urine output (HP:0012590)1.43055262
148Gingivitis (HP:0000230)1.41649600
149Tubular atrophy (HP:0000092)1.40734113
150Lissencephaly (HP:0001339)1.40114733
151Choroideremia (HP:0001139)1.39317713
152Microglossia (HP:0000171)1.39313505
153Neonatal hypoglycemia (HP:0001998)1.38767859
154Abnormality of the pericardium (HP:0001697)1.37736850
155Abnormality of molar morphology (HP:0011070)1.37490197
156Abnormality of molar (HP:0011077)1.37490197
157Elevated erythrocyte sedimentation rate (HP:0003565)1.35248633
158Recurrent abscess formation (HP:0002722)1.35137273
159Truncal obesity (HP:0001956)1.34793806
160Polyuria (HP:0000103)1.33777159
161Rectal prolapse (HP:0002035)1.32528087
162Hemorrhage of the eye (HP:0011885)1.32083545
163Neoplasm of the heart (HP:0100544)1.31976657
164Abnormality of the renal cortex (HP:0011035)1.31290414
165Eczematoid dermatitis (HP:0000976)1.30295813
16611 pairs of ribs (HP:0000878)1.29761763
167Abnormality of the dental pulp (HP:0006479)1.29015742
168Recurrent gram-negative bacterial infections (HP:0005420)1.26337980
169Progressive inability to walk (HP:0002505)1.25743560
170Adrenal overactivity (HP:0002717)1.23559395
171Decreased central vision (HP:0007663)1.23015103
172Hypokalemia (HP:0002900)1.21727989
173Abnormality of renin-angiotensin system (HP:0000847)1.21135747
174Congenital hepatic fibrosis (HP:0002612)1.20867292
175Hypoplasia of the capital femoral epiphysis (HP:0003090)1.20303414
176Recurrent bacterial skin infections (HP:0005406)1.20139869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.66708802
2PDK47.66708802
3LATS16.92215456
4NUAK15.37142098
5PDK24.98870616
6LMTK23.91805358
7PLK23.59549315
8TXK3.42733057
9TESK13.32619870
10PRKD33.26401426
11MAP4K23.18830703
12ICK2.67503652
13ACVR1B2.44393196
14IRAK12.30429215
15MAP4K12.21321694
16TRIM281.77135378
17SRPK11.75215278
18MST41.71104991
19CCNB11.69010278
20NEK21.64566469
21BCR1.57026398
22IRAK31.55289744
23WNK11.53958263
24EPHA31.49582931
25NEK61.43860198
26SCYL21.40783148
27EPHA41.35085727
28INSRR1.31509685
29PDK11.30048750
30IRAK41.29894721
31ADRBK21.29586133
32IRAK21.20361656
33CDC71.19248411
34BCKDK1.19068638
35PRKG21.17616517
36MAPK151.14298238
37EPHB11.12357057
38MAP3K141.11747103
39WNK41.11512819
40WNK31.10819326
41RIPK41.10798533
42NME21.10225169
43DDR21.09849374
44STK391.08725920
45PTK2B1.06160341
46CAMK1G0.99491346
47DYRK1B0.99097715
48TRPM70.96970139
49GRK10.93216523
50CAMK1D0.88801035
51CDK120.87906797
52STK38L0.85604280
53YES10.83726089
54BRD40.81575094
55MAPK110.80973246
56MAP3K30.80446004
57BUB10.74766411
58NEK90.73875581
59FGFR10.73080077
60PDPK10.68816509
61VRK10.67805558
62OBSCN0.67615695
63PASK0.67298501
64CAMK40.66946912
65PLK40.64970792
66SIK30.64849363
67TAOK20.63644877
68PIK3CG0.61135773
69ITK0.59148347
70FRK0.59072865
71LRRK20.58392179
72MAP3K20.57326602
73CSK0.54791422
74PIM10.54739006
75DYRK1A0.54523578
76TBK10.53101322
77BMPR1B0.52645619
78PLK10.52621660
79PRKAA10.51858763
80CSF1R0.51739978
81CDK60.51223370
82PKN10.48870776
83BRSK20.47977897
84NME10.47955024
85CSNK1G20.47674900
86ZAP700.47548419
87GRK70.47217928
88CDK70.46471809
89MAP3K50.45744811
90MAPK130.45640409
91MAP2K60.45281120
92MUSK0.43914031
93FGFR40.43813508
94FGFR30.43180857
95NLK0.43086056
96CHEK20.42866285
97TAOK10.42654342
98FES0.42512248
99PRKG10.42412100
100MAPK70.40438314
101STK380.40411401
102MAP3K130.40195528
103FGR0.40141211
104PRKAA20.39935370
105CDK10.39715789
106JAK30.39523415
107MAP3K110.38917700
108DAPK30.38710557
109RPS6KB10.38626405
110HCK0.37613779
111MAP2K30.37303932
112MTOR0.36495857
113SYK0.35727810
114MARK30.34815259
115DMPK0.34347010
116ATR0.34054419
117STK30.33197960
118CDK20.31946137
119PRKACB0.31925118
120PRKCB0.31284341
121BTK0.29665749
122CSNK1A10.29548575
123FER0.29124717
124TEC0.28412756
125ERBB40.28262658
126JAK10.28226674
127MKNK20.27988766
128PRKCG0.27616478
129PAK30.27371165
130GSK3B0.26869052
131PLK30.26740154
132IGF1R0.26678451
133VRK20.26524899
134PRKCD0.26344719
135CSNK1G30.25068371
136AKT30.24937834
137STK240.24832291
138MAPK140.24756474
139MAP2K10.24596963
140PRKCE0.24347717
141LYN0.23940562
142MAPK80.23723988
143TTK0.23211643
144FGFR20.22745735
145STK100.22191439
146PAK40.21847883
147RPS6KA60.21645748
148TNK20.21278417
149BLK0.21143767
150MAPK10.21119795
151CAMK10.19712852
152RPS6KA10.19601319
153CAMK2A0.19214135
154TRIB30.19120079
155DYRK30.18683132
156ADRBK10.18347241
157TIE10.17913196
158PRKCQ0.16981835
159ERBB30.16568123
160CHEK10.16041760
161DAPK10.15508173
162MAP2K70.15457503
163IKBKB0.14309551
164LCK0.14280584
165RPS6KB20.13766040
166ATM0.13284858
167PIM20.11922475
168TYK20.11621858
169MAP3K10.10761330
170RPS6KC10.08948139
171RPS6KL10.08948139
172BRSK10.08752944
173MYLK0.08235310

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.22868609
2RNA polymerase_Homo sapiens_hsa030203.73873904
3Olfactory transduction_Homo sapiens_hsa047403.25625441
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.13383708
5Type I diabetes mellitus_Homo sapiens_hsa049402.95887252
6Asthma_Homo sapiens_hsa053102.88334373
7Propanoate metabolism_Homo sapiens_hsa006402.77253751
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.67799341
9Rheumatoid arthritis_Homo sapiens_hsa053232.62696665
10Lysine degradation_Homo sapiens_hsa003102.58637596
11Vitamin B6 metabolism_Homo sapiens_hsa007502.58631937
12Fatty acid biosynthesis_Homo sapiens_hsa000612.54554783
13RNA transport_Homo sapiens_hsa030132.50801526
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49986320
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45386987
16Legionellosis_Homo sapiens_hsa051342.37008947
17Carbohydrate digestion and absorption_Homo sapiens_hsa049732.35465095
18Pyruvate metabolism_Homo sapiens_hsa006202.28808946
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.26519363
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23367088
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.18262050
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09829483
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.05002333
24Hedgehog signaling pathway_Homo sapiens_hsa043401.96702714
25Cell cycle_Homo sapiens_hsa041101.94047174
26Allograft rejection_Homo sapiens_hsa053301.91553162
27Steroid biosynthesis_Homo sapiens_hsa001001.86024045
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.85417672
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.84200577
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82108681
31Salmonella infection_Homo sapiens_hsa051321.81957130
32Dorso-ventral axis formation_Homo sapiens_hsa043201.78164617
33Mineral absorption_Homo sapiens_hsa049781.77736738
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72929623
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71855554
36Glucagon signaling pathway_Homo sapiens_hsa049221.69824277
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68167585
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.64710901
39Basal cell carcinoma_Homo sapiens_hsa052171.62112963
40Wnt signaling pathway_Homo sapiens_hsa043101.60875073
41Measles_Homo sapiens_hsa051621.58637868
42Fatty acid degradation_Homo sapiens_hsa000711.51311806
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39439694
44Collecting duct acid secretion_Homo sapiens_hsa049661.34654212
45Fanconi anemia pathway_Homo sapiens_hsa034601.33860816
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30624367
47Tuberculosis_Homo sapiens_hsa051521.29285691
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28083105
49Non-homologous end-joining_Homo sapiens_hsa034501.26634255
50Base excision repair_Homo sapiens_hsa034101.23261118
51Pertussis_Homo sapiens_hsa051331.20224451
52Pentose phosphate pathway_Homo sapiens_hsa000301.18659293
53Homologous recombination_Homo sapiens_hsa034401.17280875
54RNA degradation_Homo sapiens_hsa030181.16847455
55Spliceosome_Homo sapiens_hsa030401.16746492
56Influenza A_Homo sapiens_hsa051641.15890031
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.14670051
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13692038
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13685498
60Autoimmune thyroid disease_Homo sapiens_hsa053201.10782760
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07425640
62Leishmaniasis_Homo sapiens_hsa051401.06097803
63Selenocompound metabolism_Homo sapiens_hsa004501.02259523
64Glycosaminoglycan degradation_Homo sapiens_hsa005311.00494442
65Osteoclast differentiation_Homo sapiens_hsa043800.99743696
66Fructose and mannose metabolism_Homo sapiens_hsa000510.99161588
67Taste transduction_Homo sapiens_hsa047420.98044124
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96146116
69PPAR signaling pathway_Homo sapiens_hsa033200.93887194
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93808122
71Glycerolipid metabolism_Homo sapiens_hsa005610.92836575
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92157265
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90851635
74Linoleic acid metabolism_Homo sapiens_hsa005910.90807904
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90404567
76mRNA surveillance pathway_Homo sapiens_hsa030150.90055185
77Hematopoietic cell lineage_Homo sapiens_hsa046400.89529061
78Melanogenesis_Homo sapiens_hsa049160.86441970
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86154781
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83183680
81Fatty acid metabolism_Homo sapiens_hsa012120.81225782
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80918157
83Purine metabolism_Homo sapiens_hsa002300.76631903
84Salivary secretion_Homo sapiens_hsa049700.75531783
85Staphylococcus aureus infection_Homo sapiens_hsa051500.75078642
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74744818
87TNF signaling pathway_Homo sapiens_hsa046680.74429813
88Malaria_Homo sapiens_hsa051440.74229757
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.73204582
90Retinol metabolism_Homo sapiens_hsa008300.72591505
91Carbon metabolism_Homo sapiens_hsa012000.68827177
92Mismatch repair_Homo sapiens_hsa034300.68430575
93African trypanosomiasis_Homo sapiens_hsa051430.68348808
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65846905
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.65829083
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65764819
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.63430484
98Synaptic vesicle cycle_Homo sapiens_hsa047210.63370818
99Hippo signaling pathway_Homo sapiens_hsa043900.59240465
100Vibrio cholerae infection_Homo sapiens_hsa051100.58657536
101Arachidonic acid metabolism_Homo sapiens_hsa005900.58198353
102Renin secretion_Homo sapiens_hsa049240.58157843
103HTLV-I infection_Homo sapiens_hsa051660.58150801
104Sphingolipid metabolism_Homo sapiens_hsa006000.57016918
105Huntingtons disease_Homo sapiens_hsa050160.56344789
106Oocyte meiosis_Homo sapiens_hsa041140.56089694
107ABC transporters_Homo sapiens_hsa020100.56023395
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55635325
109Chemical carcinogenesis_Homo sapiens_hsa052040.55599352
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54795197
111Galactose metabolism_Homo sapiens_hsa000520.53565529
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51876954
113MicroRNAs in cancer_Homo sapiens_hsa052060.51600544
114Complement and coagulation cascades_Homo sapiens_hsa046100.51271596
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.50789311
116Antigen processing and presentation_Homo sapiens_hsa046120.50556143
117Metabolic pathways_Homo sapiens_hsa011000.49166548
118Ovarian steroidogenesis_Homo sapiens_hsa049130.48767455
119Morphine addiction_Homo sapiens_hsa050320.48712572
120Proteasome_Homo sapiens_hsa030500.48482747
121Insulin secretion_Homo sapiens_hsa049110.48174442
122Calcium signaling pathway_Homo sapiens_hsa040200.47776356
123Amphetamine addiction_Homo sapiens_hsa050310.47149652
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46769859
125Herpes simplex infection_Homo sapiens_hsa051680.46044394
126Cardiac muscle contraction_Homo sapiens_hsa042600.45212721
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44576991
128Pancreatic secretion_Homo sapiens_hsa049720.43446612
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42312046
130Bile secretion_Homo sapiens_hsa049760.41539983
131B cell receptor signaling pathway_Homo sapiens_hsa046620.41225338
132Oxytocin signaling pathway_Homo sapiens_hsa049210.40995318
133cAMP signaling pathway_Homo sapiens_hsa040240.40872255
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39579754
135Thyroid hormone synthesis_Homo sapiens_hsa049180.39224464
136Pyrimidine metabolism_Homo sapiens_hsa002400.38573275
137Glutathione metabolism_Homo sapiens_hsa004800.38326486
138Cholinergic synapse_Homo sapiens_hsa047250.37483518
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.36955210
140Dilated cardiomyopathy_Homo sapiens_hsa054140.36014743
141Sulfur relay system_Homo sapiens_hsa041220.34157525
142Epstein-Barr virus infection_Homo sapiens_hsa051690.33733429
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.32457816
144T cell receptor signaling pathway_Homo sapiens_hsa046600.32456047
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32077523
146Phagosome_Homo sapiens_hsa041450.31723193
147Toxoplasmosis_Homo sapiens_hsa051450.31603608
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29658887
149One carbon pool by folate_Homo sapiens_hsa006700.29566099
150Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28958562
151Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28825340
152Inositol phosphate metabolism_Homo sapiens_hsa005620.28674322
153Peroxisome_Homo sapiens_hsa041460.28357227
154Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27548628
155ECM-receptor interaction_Homo sapiens_hsa045120.27090288
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26793566
157HIF-1 signaling pathway_Homo sapiens_hsa040660.26779745
158Systemic lupus erythematosus_Homo sapiens_hsa053220.25097565
159Basal transcription factors_Homo sapiens_hsa030220.24326703
160Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23554029
161Circadian entrainment_Homo sapiens_hsa047130.23120863
162Biosynthesis of amino acids_Homo sapiens_hsa012300.22880779
163Primary bile acid biosynthesis_Homo sapiens_hsa001200.22683337
164Small cell lung cancer_Homo sapiens_hsa052220.22228788
165Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20882570
166Butanoate metabolism_Homo sapiens_hsa006500.20854085

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