ARID4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.09490541
2central nervous system myelination (GO:0022010)7.09490541
3cornea development in camera-type eye (GO:0061303)6.32604897
4establishment of protein localization to Golgi (GO:0072600)4.76114486
5neural tube formation (GO:0001841)4.69383524
6limb bud formation (GO:0060174)4.59381256
7protein targeting to Golgi (GO:0000042)4.47308125
8long-chain fatty acid biosynthetic process (GO:0042759)4.40053041
9myelination (GO:0042552)4.26038121
10ensheathment of neurons (GO:0007272)4.19023869
11axon ensheathment (GO:0008366)4.19023869
12regulation of timing of cell differentiation (GO:0048505)4.17423947
13presynaptic membrane assembly (GO:0097105)4.14094664
14negative regulation of neurotransmitter secretion (GO:0046929)4.08648884
15presynaptic membrane organization (GO:0097090)4.05538778
16retrograde transport, vesicle recycling within Golgi (GO:0000301)3.99307661
17eye photoreceptor cell differentiation (GO:0001754)3.91028216
18photoreceptor cell differentiation (GO:0046530)3.91028216
19positive regulation of cell fate commitment (GO:0010455)3.81961524
20regulation of development, heterochronic (GO:0040034)3.79412290
21hindbrain development (GO:0030902)3.73699402
22cerebral cortex radially oriented cell migration (GO:0021799)3.73373188
23negative regulation of neurotransmitter transport (GO:0051589)3.68398930
24protein K11-linked deubiquitination (GO:0035871)3.58358956
25fatty acid elongation (GO:0030497)3.55452651
26DNA deamination (GO:0045006)3.52793870
27regulation of telomere maintenance (GO:0032204)3.31954454
28protein localization to Golgi apparatus (GO:0034067)3.31881398
29oligodendrocyte differentiation (GO:0048709)3.28621797
30asymmetric protein localization (GO:0008105)3.27950748
31neuron cell-cell adhesion (GO:0007158)3.25357242
32prenylation (GO:0097354)3.25001669
33protein prenylation (GO:0018342)3.25001669
34behavioral response to nicotine (GO:0035095)3.24274344
35regulation of collateral sprouting (GO:0048670)3.23219607
36epithelial cilium movement (GO:0003351)3.16394165
37regulation of pigment cell differentiation (GO:0050932)3.12927939
38regulation of cilium movement (GO:0003352)3.09995769
39histone H3-K4 trimethylation (GO:0080182)3.08098425
40negative regulation of protein localization to cell surface (GO:2000009)3.07046124
41glycerophospholipid catabolic process (GO:0046475)3.06041056
42photoreceptor cell development (GO:0042461)3.03909417
43microtubule anchoring (GO:0034453)3.02176049
44histone H2B ubiquitination (GO:0033523)3.02019368
45negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.00678557
46retina layer formation (GO:0010842)3.00650959
47RNA destabilization (GO:0050779)2.98365608
48response to redox state (GO:0051775)2.98114258
49apical protein localization (GO:0045176)2.97252112
50GPI anchor biosynthetic process (GO:0006506)2.96515530
51L-fucose catabolic process (GO:0042355)2.96239719
52fucose catabolic process (GO:0019317)2.96239719
53L-fucose metabolic process (GO:0042354)2.96239719
54transmission of nerve impulse (GO:0019226)2.94267039
55positive regulation of defense response to virus by host (GO:0002230)2.94119145
56axoneme assembly (GO:0035082)2.92048164
57reciprocal DNA recombination (GO:0035825)2.91565089
58reciprocal meiotic recombination (GO:0007131)2.91565089
59preassembly of GPI anchor in ER membrane (GO:0016254)2.90762395
60replication fork processing (GO:0031297)2.88931492
61centriole replication (GO:0007099)2.87828715
62cilium morphogenesis (GO:0060271)2.87207982
63negative regulation of execution phase of apoptosis (GO:1900118)2.86384953
64rRNA catabolic process (GO:0016075)2.83943986
65activated T cell proliferation (GO:0050798)2.82842655
66seminiferous tubule development (GO:0072520)2.82652708
67cellular response to interleukin-15 (GO:0071350)2.82504855
68dorsal/ventral axis specification (GO:0009950)2.81707269
69GPI anchor metabolic process (GO:0006505)2.81586972
70monoubiquitinated protein deubiquitination (GO:0035520)2.80167873
71eye photoreceptor cell development (GO:0042462)2.79662333
72positive regulation of action potential (GO:0045760)2.79514684
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.78828717
74response to pheromone (GO:0019236)2.78491972
75response to epinephrine (GO:0071871)2.77036141
76embryonic epithelial tube formation (GO:0001838)2.74114947
77positive regulation of meiosis (GO:0045836)2.69055947
78astrocyte differentiation (GO:0048708)2.68689377
79lateral sprouting from an epithelium (GO:0060601)2.67488723
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.66896572
81cellular response to epinephrine stimulus (GO:0071872)2.66100064
82synapsis (GO:0007129)2.65721958
83mast cell degranulation (GO:0043303)2.63913094
84mast cell activation involved in immune response (GO:0002279)2.63913094
85positive regulation of oligodendrocyte differentiation (GO:0048714)2.62010470
86negative regulation of mast cell activation (GO:0033004)2.61232130
87developmental pigmentation (GO:0048066)2.61181542
88negative regulation of axon extension (GO:0030517)2.60266810
89nucleotide transmembrane transport (GO:1901679)2.59898003
90cyclic nucleotide catabolic process (GO:0009214)2.55327161
91regulation of hexokinase activity (GO:1903299)2.54727909
92regulation of glucokinase activity (GO:0033131)2.54727909
93kynurenine metabolic process (GO:0070189)2.54424886
94interferon-gamma production (GO:0032609)2.53465865
95regulation of memory T cell differentiation (GO:0043380)2.52587771
96cranial nerve development (GO:0021545)2.52471597
97histone mRNA catabolic process (GO:0071044)2.52330114
98L-amino acid import (GO:0043092)2.52124310
99acrosome reaction (GO:0007340)2.52007110
100neuron recognition (GO:0008038)2.51671874
101epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.50801317
102myelin maintenance (GO:0043217)2.50353590
103peptidyl-tyrosine autophosphorylation (GO:0038083)2.50264296
104cilium or flagellum-dependent cell motility (GO:0001539)2.50250180
105epithelial tube formation (GO:0072175)2.50230059
106spinal cord motor neuron differentiation (GO:0021522)2.49395268
107positive regulation of meiotic cell cycle (GO:0051446)2.49166290
108cilium organization (GO:0044782)2.48586339
109regulation of meiosis I (GO:0060631)2.48540379
110regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.48424623
111positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.48424623
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.48300908
113positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.48292620
114regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.48292620
115gamma-aminobutyric acid signaling pathway (GO:0007214)2.47518251
116protein polyglutamylation (GO:0018095)2.46947663
117multicellular organism reproduction (GO:0032504)2.46193030
118centriole assembly (GO:0098534)2.46105831
119positive regulation of neuroblast proliferation (GO:0002052)2.45727962
120pyrimidine nucleobase catabolic process (GO:0006208)2.45239486
121keratinocyte development (GO:0003334)2.44874524
122adaptation of signaling pathway (GO:0023058)2.44825356
123neuron remodeling (GO:0016322)2.44529061
124negative regulation of myoblast differentiation (GO:0045662)2.44490669
125cilium movement (GO:0003341)2.44462918
126positive regulation of mRNA catabolic process (GO:0061014)2.43801731
127intraciliary transport (GO:0042073)2.43476226
128male meiosis I (GO:0007141)2.43025911
129somite development (GO:0061053)2.43015023
130regulation of somitogenesis (GO:0014807)2.42870040
131negative regulation of translation, ncRNA-mediated (GO:0040033)2.42623274
132regulation of translation, ncRNA-mediated (GO:0045974)2.42623274
133negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42623274
134regulation of DNA endoreduplication (GO:0032875)2.41571392
135cytidine metabolic process (GO:0046087)2.41048781
136cytidine catabolic process (GO:0006216)2.41048781
137cytidine deamination (GO:0009972)2.41048781
138cilium assembly (GO:0042384)2.40660784
139pituitary gland development (GO:0021983)2.40563378
140organ growth (GO:0035265)2.40279262
141detection of light stimulus involved in visual perception (GO:0050908)2.39924794
142detection of light stimulus involved in sensory perception (GO:0050962)2.39924794
143protein K63-linked deubiquitination (GO:0070536)2.39804763
144regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.39130069
145regulation of mitotic spindle checkpoint (GO:1903504)2.39130069
146import into cell (GO:0098657)2.39047617
147negative regulation of DNA-dependent DNA replication (GO:2000104)2.38049345
148ncRNA catabolic process (GO:0034661)2.37656177
149response to monoamine (GO:0071867)2.37271967
150response to catecholamine (GO:0071869)2.37271967
151regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.37047549
152forebrain neuron differentiation (GO:0021879)2.35557492
153olfactory bulb development (GO:0021772)2.35364579
154recombinational repair (GO:0000725)2.34068327
155double-strand break repair via homologous recombination (GO:0000724)2.33775565
156nonmotile primary cilium assembly (GO:0035058)2.32803122
157regulation of feeding behavior (GO:0060259)2.32516052
158negative regulation of JUN kinase activity (GO:0043508)2.31493541
159mesenchymal cell differentiation involved in renal system development (GO:2001012)2.30119462
160mesenchymal cell differentiation involved in kidney development (GO:0072161)2.30119462
161substrate-independent telencephalic tangential migration (GO:0021826)2.29966888
162substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.29966888
163negative regulation of exocytosis (GO:0045920)2.29598305
164otic vesicle formation (GO:0030916)2.29029911
165startle response (GO:0001964)2.28992245
166magnesium ion transport (GO:0015693)2.27383622
167peripheral nervous system axon ensheathment (GO:0032292)2.25572701
168myelination in peripheral nervous system (GO:0022011)2.25572701
169regulation of neuron projection regeneration (GO:0070570)2.25068375
170regulation of axon regeneration (GO:0048679)2.25068375
171negative regulation of axonogenesis (GO:0050771)2.24020064
172dendrite development (GO:0016358)2.22161157
173glycolipid biosynthetic process (GO:0009247)2.21544719
174substantia nigra development (GO:0021762)2.18731294
175axonal fasciculation (GO:0007413)2.16678933
176postsynaptic membrane organization (GO:0001941)2.16644335
177cellular response to catecholamine stimulus (GO:0071870)2.14833372
178cellular response to monoamine stimulus (GO:0071868)2.14833372
179adult walking behavior (GO:0007628)2.14561981
180protein palmitoylation (GO:0018345)2.14514385
181neuronal ion channel clustering (GO:0045161)2.14496944
182negative regulation of transcription by competitive promoter binding (GO:0010944)2.13224608
183astrocyte development (GO:0014002)2.13131122
184ear development (GO:0043583)2.11626877
185regulation of catecholamine metabolic process (GO:0042069)2.10857827
186regulation of dopamine metabolic process (GO:0042053)2.10857827

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.46240121
2EZH2_22144423_ChIP-Seq_EOC_Human3.39377037
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.01302343
4ZNF274_21170338_ChIP-Seq_K562_Hela2.62167009
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59911332
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45175463
7* TAF15_26573619_Chip-Seq_HEK293_Human2.39327350
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37856993
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.19509540
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.19021690
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15109677
12VDR_22108803_ChIP-Seq_LS180_Human2.12006700
13FUS_26573619_Chip-Seq_HEK293_Human2.07328333
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04491457
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03447318
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.03308087
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00271938
18BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95947330
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93619574
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90961180
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90887242
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88892632
23* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87981523
24P300_19829295_ChIP-Seq_ESCs_Human1.86580704
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.85847616
26AR_21572438_ChIP-Seq_LNCaP_Human1.84558563
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81465642
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79370869
29CBP_20019798_ChIP-Seq_JUKART_Human1.74758604
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74758604
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74456308
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73376058
33ER_23166858_ChIP-Seq_MCF-7_Human1.72618590
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.72391084
35RNF2_27304074_Chip-Seq_NSC_Mouse1.72303005
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71713724
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70303710
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70139985
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.69115718
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.68663193
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68579982
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68442423
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67495811
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65623099
45EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65623099
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65546734
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63722872
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62714562
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.62356865
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61331214
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.61076671
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60796585
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60129438
54EWS_26573619_Chip-Seq_HEK293_Human1.58950002
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57259477
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55228883
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54813251
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.53803952
59BCAT_22108803_ChIP-Seq_LS180_Human1.53780812
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.51853134
61SMAD4_21799915_ChIP-Seq_A2780_Human1.50981212
62SUZ12_18555785_Chip-Seq_ESCs_Mouse1.50564055
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48960736
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.48813103
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.48757036
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48354857
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47735662
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.45471043
69P53_22387025_ChIP-Seq_ESCs_Mouse1.45310059
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44209909
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44127811
72IGF1R_20145208_ChIP-Seq_DFB_Human1.43816345
73IRF1_19129219_ChIP-ChIP_H3396_Human1.43161829
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42433684
75P300_18555785_Chip-Seq_ESCs_Mouse1.41274675
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.41157174
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40873739
78* FLI1_21867929_ChIP-Seq_TH2_Mouse1.40363322
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.39872489
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39272107
81IRF8_22096565_ChIP-ChIP_GC-B_Human1.37161622
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36932410
83AR_25329375_ChIP-Seq_VCAP_Human1.35424312
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34180120
85STAT3_23295773_ChIP-Seq_U87_Human1.34157208
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33752252
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.32732327
88SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32208677
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31565530
90TAL1_26923725_Chip-Seq_HPCs_Mouse1.31322396
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.30573479
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30205734
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29675516
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29213557
95TCF4_22108803_ChIP-Seq_LS180_Human1.27739116
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27022997
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26777149
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26777149
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26657767
100* TCF4_23295773_ChIP-Seq_U87_Human1.26649773
101NMYC_18555785_Chip-Seq_ESCs_Mouse1.25644030
102WT1_19549856_ChIP-ChIP_CCG9911_Human1.25428159
103* TP53_22573176_ChIP-Seq_HFKS_Human1.25182058
104SOX2_18555785_Chip-Seq_ESCs_Mouse1.24616054
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.24601151
106RUNX1_27457419_Chip-Seq_LIVER_Mouse1.21078481
107AHR_22903824_ChIP-Seq_MCF-7_Human1.19484226
108TP53_16413492_ChIP-PET_HCT116_Human1.17874169
109RUNX2_22187159_ChIP-Seq_PCA_Human1.17536161
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17431430
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17316588
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17020519
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.16448769
114RUNX_20019798_ChIP-Seq_JUKART_Human1.16330891
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.15713049
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14335201
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13668396
118HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12592724
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12266682
120TP53_18474530_ChIP-ChIP_U2OS_Human1.12193552
121ZFX_18555785_Chip-Seq_ESCs_Mouse1.11056320
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.10504216
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10403608
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.09699016
125GATA3_26560356_Chip-Seq_TH2_Human1.09488568
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09479838
127TP63_19390658_ChIP-ChIP_HaCaT_Human1.09308760
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09151685
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09045813
130SOX2_19829295_ChIP-Seq_ESCs_Human1.08953924
131NANOG_19829295_ChIP-Seq_ESCs_Human1.08953924
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08945474
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08819934
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06610991
135MYC_18940864_ChIP-ChIP_HL60_Human1.05172892
136SMAD4_21741376_ChIP-Seq_EPCs_Human1.05047768
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01731851
138ELK1_19687146_ChIP-ChIP_HELA_Human1.00611261
139HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99314631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.92338709
2MP0003880_abnormal_central_pattern3.83727670
3MP0005409_darkened_coat_color3.80434309
4* MP0008877_abnormal_DNA_methylation3.46362863
5MP0001188_hyperpigmentation3.29952023
6MP0003136_yellow_coat_color3.17403213
7MP0005171_absent_coat_pigmentation2.96946505
8MP0000920_abnormal_myelination2.72234159
9MP0000566_synostosis2.59115524
10MP0008789_abnormal_olfactory_epithelium2.41708364
11MP0006292_abnormal_olfactory_placode2.30819030
12MP0004742_abnormal_vestibular_system2.20431303
13MP0000778_abnormal_nervous_system2.19315240
14MP0005423_abnormal_somatic_nervous2.16094371
15MP0001486_abnormal_startle_reflex2.13945963
16MP0004381_abnormal_hair_follicle2.09222815
17MP0004270_analgesia2.03522214
18MP0005394_taste/olfaction_phenotype1.92527774
19MP0005499_abnormal_olfactory_system1.92527774
20MP0003950_abnormal_plasma_membrane1.84558668
21MP0005257_abnormal_intraocular_pressure1.81798192
22MP0003195_calcinosis1.81407102
23MP0001529_abnormal_vocalization1.80398587
24MP0003724_increased_susceptibility_to1.78592570
25MP0002272_abnormal_nervous_system1.72084830
26MP0001905_abnormal_dopamine_level1.70471996
27MP0001485_abnormal_pinna_reflex1.70195732
28MP0005551_abnormal_eye_electrophysiolog1.65543830
29MP0000383_abnormal_hair_follicle1.64017963
30MP0005671_abnormal_response_to1.60571758
31MP0002009_preneoplasia1.59970424
32MP0009745_abnormal_behavioral_response1.54693281
33MP0004134_abnormal_chest_morphology1.53005019
34MP0004885_abnormal_endolymph1.52634179
35MP0001968_abnormal_touch/_nociception1.51538848
36MP0006072_abnormal_retinal_apoptosis1.51091403
37MP0005645_abnormal_hypothalamus_physiol1.50400781
38MP0005379_endocrine/exocrine_gland_phen1.49696467
39MP0000427_abnormal_hair_cycle1.41468735
40MP0010678_abnormal_skin_adnexa1.41190780
41MP0005646_abnormal_pituitary_gland1.37636110
42MP0001919_abnormal_reproductive_system1.37072091
43MP0001346_abnormal_lacrimal_gland1.36308734
44MP0002064_seizures1.34460362
45MP0009379_abnormal_foot_pigmentation1.34425309
46MP0002938_white_spotting1.34305705
47MP0000462_abnormal_digestive_system1.32885128
48MP0002160_abnormal_reproductive_system1.32355900
49MP0002734_abnormal_mechanical_nocicepti1.31853030
50MP0003937_abnormal_limbs/digits/tail_de1.31114659
51MP0002102_abnormal_ear_morphology1.29820693
52MP0008995_early_reproductive_senescence1.29734867
53MP0005389_reproductive_system_phenotype1.29677477
54MP0002163_abnormal_gland_morphology1.29230290
55MP0004142_abnormal_muscle_tone1.26592937
56MP0002928_abnormal_bile_duct1.25311056
57MP0009046_muscle_twitch1.24549854
58MP0002572_abnormal_emotion/affect_behav1.22605082
59MP0001963_abnormal_hearing_physiology1.21135874
60MP0000631_abnormal_neuroendocrine_gland1.20435001
61MP0001502_abnormal_circadian_rhythm1.20113350
62MP0003635_abnormal_synaptic_transmissio1.19170529
63MP0000026_abnormal_inner_ear1.18571012
64MP0000015_abnormal_ear_pigmentation1.18170869
65MP0002736_abnormal_nociception_after1.17373739
66MP0001440_abnormal_grooming_behavior1.15318173
67MP0008058_abnormal_DNA_repair1.14896720
68MP0003938_abnormal_ear_development1.13592046
69MP0006276_abnormal_autonomic_nervous1.13485580
70MP0001986_abnormal_taste_sensitivity1.12203172
71MP0002752_abnormal_somatic_nervous1.11523112
72MP0002882_abnormal_neuron_morphology1.11042498
73MP0004133_heterotaxia1.10991634
74MP0009250_abnormal_appendicular_skeleto1.10584585
75MP0008057_abnormal_DNA_replication1.09656527
76MP0002277_abnormal_respiratory_mucosa1.09437744
77MP0003122_maternal_imprinting1.09372749
78MP0005253_abnormal_eye_physiology1.08384998
79MP0000762_abnormal_tongue_morphology1.07924195
80MP0001177_atelectasis1.07354637
81* MP0003787_abnormal_imprinting1.07282511
82MP0002234_abnormal_pharynx_morphology1.07125361
83MP0002557_abnormal_social/conspecific_i1.06017571
84MP0000049_abnormal_middle_ear1.05350327
85MP0001800_abnormal_humoral_immune1.04380318
86MP0001984_abnormal_olfaction1.03135428
87MP0002063_abnormal_learning/memory/cond1.02910374
88MP0002909_abnormal_adrenal_gland1.02629149
89MP0002067_abnormal_sensory_capabilities1.02150112
90MP0002184_abnormal_innervation1.00895191
91MP0008872_abnormal_physiological_respon0.99455581
92MP0000955_abnormal_spinal_cord0.99441729
93MP0005075_abnormal_melanosome_morpholog0.99210435
94MP0005084_abnormal_gallbladder_morpholo0.99096188
95MP0003385_abnormal_body_wall0.97105994
96MP0004147_increased_porphyrin_level0.96436777
97MP0003632_abnormal_nervous_system0.94941927
98MP0002229_neurodegeneration0.94411024
99MP0003634_abnormal_glial_cell0.94138532
100MP0001851_eye_inflammation0.94097700
101MP0003690_abnormal_glial_cell0.93800445
102MP0001501_abnormal_sleep_pattern0.93520925
103MP0005195_abnormal_posterior_eye0.93381230
104MP0001299_abnormal_eye_distance/0.92375392
105MP0003755_abnormal_palate_morphology0.91821945
106MP0001929_abnormal_gametogenesis0.91005288
107MP0005410_abnormal_fertilization0.90716201
108MP0000647_abnormal_sebaceous_gland0.90635831
109MP0002837_dystrophic_cardiac_calcinosis0.90156694
110MP0003698_abnormal_male_reproductive0.90072872
111MP0002177_abnormal_outer_ear0.88201124
112MP0002233_abnormal_nose_morphology0.88089954
113MP0002876_abnormal_thyroid_physiology0.87405911
114MP0003763_abnormal_thymus_physiology0.87209652
115MP0008961_abnormal_basal_metabolism0.87182525
116MP0005174_abnormal_tail_pigmentation0.87032857
117MP0008569_lethality_at_weaning0.86250570
118MP0004859_abnormal_synaptic_plasticity0.85023096
119MP0005310_abnormal_salivary_gland0.84728406
120MP0003890_abnormal_embryonic-extraembry0.84110406
121MP0002751_abnormal_autonomic_nervous0.84035330
122MP0002249_abnormal_larynx_morphology0.80411837
123MP0001324_abnormal_eye_pigmentation0.79758317
124MP0006054_spinal_hemorrhage0.78729955
125MP0005391_vision/eye_phenotype0.77786758
126MP0002735_abnormal_chemical_nociception0.77399305
127MP0002210_abnormal_sex_determination0.75035897
128MP0002638_abnormal_pupillary_reflex0.73401703
129MP0004924_abnormal_behavior0.73088760
130MP0005386_behavior/neurological_phenoty0.73088760
131MP0000372_irregular_coat_pigmentation0.72879627
132* MP0003121_genomic_imprinting0.72858253
133MP0002723_abnormal_immune_serum0.72537164
134MP0000653_abnormal_sex_gland0.72106107
135MP0002095_abnormal_skin_pigmentation0.70902042
136MP0000613_abnormal_salivary_gland0.70896453
137MP0001970_abnormal_pain_threshold0.70153902
138MP0002152_abnormal_brain_morphology0.69928754
139MP0010386_abnormal_urinary_bladder0.69593533
140MP0002693_abnormal_pancreas_physiology0.69312647
141MP0003567_abnormal_fetal_cardiomyocyte0.68271356
142MP0001119_abnormal_female_reproductive0.68008824
143MP0003252_abnormal_bile_duct0.66882109
144MP0001944_abnormal_pancreas_morphology0.66340181
145MP0001145_abnormal_male_reproductive0.65572261
146MP0002420_abnormal_adaptive_immunity0.63330887

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)3.84140599
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.84140599
3Pancreatic cysts (HP:0001737)3.66277213
4Aplasia/Hypoplasia of the fovea (HP:0008060)3.58609173
5Hypoplasia of the fovea (HP:0007750)3.58609173
6Parakeratosis (HP:0001036)3.27881166
7True hermaphroditism (HP:0010459)3.13526222
8White forelock (HP:0002211)3.08907193
9Absent/shortened dynein arms (HP:0200106)2.99622966
10Dynein arm defect of respiratory motile cilia (HP:0012255)2.99622966
11Abnormality of the renal cortex (HP:0011035)2.96286535
12Abnormality of the fovea (HP:0000493)2.94400042
13Abnormal ciliary motility (HP:0012262)2.94274245
14Patchy hypopigmentation of hair (HP:0011365)2.88891529
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.84746119
16Thyroiditis (HP:0100646)2.84329272
17Hyperventilation (HP:0002883)2.83200349
18Neurofibrillary tangles (HP:0002185)2.82492365
19Sensory axonal neuropathy (HP:0003390)2.80958471
20Abnormality of incisor morphology (HP:0011063)2.79893675
21Congenital stationary night blindness (HP:0007642)2.79783803
22Renal cortical cysts (HP:0000803)2.79756725
23Abnormal hair whorl (HP:0010721)2.77998472
24Cupped ear (HP:0000378)2.77667004
25Alacrima (HP:0000522)2.76891678
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.68629871
27Neoplasm of the tracheobronchial system (HP:0100552)2.65827681
28Thickened helices (HP:0000391)2.61456470
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60749687
30Abnormal rod and cone electroretinograms (HP:0008323)2.58035934
31Decreased lacrimation (HP:0000633)2.56536120
32Abnormality of the corticospinal tract (HP:0002492)2.55673852
33Chronic hepatic failure (HP:0100626)2.55254968
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.54091556
35Abnormality of T cell number (HP:0011839)2.51302002
36Gaze-evoked nystagmus (HP:0000640)2.51013455
37Aplasia/Hypoplasia of the macula (HP:0008059)2.50775747
38Genetic anticipation (HP:0003743)2.47350998
39Abnormal respiratory motile cilium physiology (HP:0012261)2.46046699
40Septo-optic dysplasia (HP:0100842)2.42697001
41Progressive cerebellar ataxia (HP:0002073)2.41899370
42Absent speech (HP:0001344)2.40636699
43Absent septum pellucidum (HP:0001331)2.39996995
44Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.39992999
45Congenital sensorineural hearing impairment (HP:0008527)2.39341685
46Stomatitis (HP:0010280)2.36461796
47Aplasia cutis congenita (HP:0001057)2.35941647
48Severe combined immunodeficiency (HP:0004430)2.33844953
49Lip pit (HP:0100267)2.32994972
50Abnormality of eosinophils (HP:0001879)2.32275659
51Attenuation of retinal blood vessels (HP:0007843)2.32078325
52Abnormality of the septum pellucidum (HP:0007375)2.31828122
53Abnormal respiratory epithelium morphology (HP:0012253)2.30010875
54Abnormal respiratory motile cilium morphology (HP:0005938)2.30010875
55Aplasia/Hypoplasia affecting the retina (HP:0008061)2.28922891
56Anteriorly placed anus (HP:0001545)2.28792537
57Widely spaced teeth (HP:0000687)2.28626217
58T lymphocytopenia (HP:0005403)2.28105058
59Stomach cancer (HP:0012126)2.23289817
60Tubulointerstitial nephritis (HP:0001970)2.21378392
61Metaphyseal dysplasia (HP:0100255)2.20387792
62Optic nerve coloboma (HP:0000588)2.17912333
63Abnormal auditory evoked potentials (HP:0006958)2.14796968
64Conical tooth (HP:0000698)2.12175351
65Volvulus (HP:0002580)2.08981138
66Abnormality of the nasolacrimal system (HP:0000614)2.08806332
67Abnormality of the phalanges of the 2nd finger (HP:0009541)2.07981913
68Molar tooth sign on MRI (HP:0002419)2.07765912
69Abnormality of midbrain morphology (HP:0002418)2.07765912
70Nasolacrimal duct obstruction (HP:0000579)2.06912708
71Abnormality of the parietal bone (HP:0002696)2.06883770
72Cystic liver disease (HP:0006706)2.06715877
73Retinal dysplasia (HP:0007973)2.04509136
74Peripheral hypomyelination (HP:0007182)2.04378105
75Aplasia/Hypoplasia of the tongue (HP:0010295)2.02350077
76IgG deficiency (HP:0004315)2.02274961
77Alveolar cell carcinoma (HP:0006519)2.01363988
78Hip dysplasia (HP:0001385)2.01318021
79Genital tract atresia (HP:0001827)1.99554492
80Postaxial foot polydactyly (HP:0001830)1.99447090
81Chin dimple (HP:0010751)1.97045832
82Protruding tongue (HP:0010808)1.96993854
83Keratitis (HP:0000491)1.95065255
84Duplicated collecting system (HP:0000081)1.94586194
85Long nose (HP:0003189)1.92451077
86Mixed hearing impairment (HP:0000410)1.91889346
87Vaginal atresia (HP:0000148)1.91815424
88Abnormality of the lacrimal duct (HP:0011481)1.91241635
89Decreased central vision (HP:0007663)1.91187526
90Abnormality of the labia minora (HP:0012880)1.91046651
91Tented upper lip vermilion (HP:0010804)1.90666328
92Short tibia (HP:0005736)1.90629121
93Optic nerve hypoplasia (HP:0000609)1.90584718
94Abnormality of the nasal septum (HP:0000419)1.90266353
95Onion bulb formation (HP:0003383)1.89877890
96Anomalous pulmonary venous return (HP:0010772)1.88080917
97Abnormality of chromosome stability (HP:0003220)1.87303137
98Adrenal hypoplasia (HP:0000835)1.87231843
99Median cleft lip (HP:0000161)1.86232036
100Abnormality of the columella (HP:0009929)1.85257367
101Fair hair (HP:0002286)1.84005500
102Truncal obesity (HP:0001956)1.83539728
103Neoplasm of the adrenal cortex (HP:0100641)1.82543961
104Gastroesophageal reflux (HP:0002020)1.82522680
105Myelomeningocele (HP:0002475)1.82126769
106Medial flaring of the eyebrow (HP:0010747)1.82001353
107Congenital hepatic fibrosis (HP:0002612)1.80814285
108Overfolded helix (HP:0000396)1.80138580
109Tubular atrophy (HP:0000092)1.80119255
110Aqueductal stenosis (HP:0002410)1.79135563
111Abnormality of the incisor (HP:0000676)1.78535344
112Gait imbalance (HP:0002141)1.78090098
113Hypoplastic ischia (HP:0003175)1.77648928
114Slow saccadic eye movements (HP:0000514)1.77641065
115Oligodactyly (hands) (HP:0001180)1.77402750
116Male pseudohermaphroditism (HP:0000037)1.77059246
117Abnormality of the renal collecting system (HP:0004742)1.77030733
118Abnormality of the renal medulla (HP:0100957)1.76359381
119Epileptic encephalopathy (HP:0200134)1.76194063
120Papillary thyroid carcinoma (HP:0002895)1.76169918
121Lissencephaly (HP:0001339)1.74978674
122Focal motor seizures (HP:0011153)1.74325868
123Asplenia (HP:0001746)1.73899128
124Intestinal atresia (HP:0011100)1.73628428
125Narrow forehead (HP:0000341)1.73009974
126Dysmetria (HP:0001310)1.72892586
127Premature skin wrinkling (HP:0100678)1.72226860
128Abnormality of secondary sexual hair (HP:0009888)1.71998831
129Abnormality of the axillary hair (HP:0100134)1.71998831
130Atelectasis (HP:0100750)1.70632345
131Hypoplasia of the iris (HP:0007676)1.70358065
132Broad-based gait (HP:0002136)1.70189952
133Prostate neoplasm (HP:0100787)1.70075169
134Abnormal drinking behavior (HP:0030082)1.70007530
135Polydipsia (HP:0001959)1.70007530
136Nephronophthisis (HP:0000090)1.69858335
137Split foot (HP:0001839)1.69139763
138Supernumerary bones of the axial skeleton (HP:0009144)1.68962928
139Congenital primary aphakia (HP:0007707)1.67738319
140Abnormality of the pulmonary veins (HP:0011718)1.67443358
141Growth hormone deficiency (HP:0000824)1.66810296
142Type II lissencephaly (HP:0007260)1.66750840
143Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.66732068
144Pendular nystagmus (HP:0012043)1.66537905
145Aplasia/Hypoplasia of the uvula (HP:0010293)1.66503167
146Ectopic anus (HP:0004397)1.65565423
147Postaxial hand polydactyly (HP:0001162)1.65514252
148Hypoplastic iliac wings (HP:0002866)1.65469972
149Midline defect of the nose (HP:0004122)1.65406801
150Scanning speech (HP:0002168)1.65339887
151Abnormality of T cells (HP:0002843)1.64361599
152Inability to walk (HP:0002540)1.64289527
153Drooling (HP:0002307)1.64120218
154Excessive salivation (HP:0003781)1.64120218
155Abolished electroretinogram (ERG) (HP:0000550)1.63303368
156Preaxial hand polydactyly (HP:0001177)1.62381354
157Eosinophilia (HP:0001880)1.62314437
158Pancreatic fibrosis (HP:0100732)1.62137598
159Aplasia involving bones of the upper limbs (HP:0009823)1.62075442
160Aplasia of the phalanges of the hand (HP:0009802)1.62075442
161Aplasia involving bones of the extremities (HP:0009825)1.62075442
162Abnormality of salivation (HP:0100755)1.62013292
163Supernumerary ribs (HP:0005815)1.61447049
164Blue irides (HP:0000635)1.61419985
165Constricted visual fields (HP:0001133)1.61375311
166Abnormal delayed hypersensitivity skin test (HP:0002963)1.60571460
167Febrile seizures (HP:0002373)1.60497552
168Hypochromic microcytic anemia (HP:0004840)1.60030382
169Small hand (HP:0200055)1.60005757
170Abnormality of molar (HP:0011077)1.59895555
171Abnormality of molar morphology (HP:0011070)1.59895555
172Increased corneal curvature (HP:0100692)1.59343836
173Highly arched eyebrow (HP:0002553)1.59311829
174Autoimmune hemolytic anemia (HP:0001890)1.58967420
175Abnormality of the ischium (HP:0003174)1.58328500
176Pachygyria (HP:0001302)1.54631506
177Sloping forehead (HP:0000340)1.54554577
178Abnormality of macular pigmentation (HP:0008002)1.54365010
179Prominent nasal bridge (HP:0000426)1.53956074

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.98326585
2STK393.98182775
3TNIK3.69284289
4MAP4K22.82234516
5CASK2.70581421
6OXSR12.64752134
7BCR2.51452355
8TAOK32.39998105
9NEK62.16276679
10PKN12.16178436
11MAP3K41.96819417
12BMPR1B1.91774049
13PNCK1.87647538
14EPHB11.80842979
15PTK2B1.77480755
16CLK11.74989467
17ACVR1B1.70642487
18BRD41.67279950
19WNK11.56103267
20AKT31.56013037
21PBK1.55507190
22FGFR21.54537687
23MKNK21.53305050
24WNK41.52528122
25BMPR21.49630410
26IRAK11.47880390
27NUAK11.45062846
28IRAK41.41377454
29CSNK1A1L1.35919256
30GRK71.35172161
31INSRR1.33946706
32PLK41.31523923
33MAPK131.31008386
34STK38L1.28994389
35CDK31.28965842
36MKNK11.26152629
37TXK1.22958672
38PRPF4B1.18677216
39MAPK151.16047974
40PINK11.15879121
41EPHA41.15718199
42TRIM281.11973539
43MAP2K71.11912709
44CSNK1G31.06463334
45STK161.05574675
46MAP3K141.04556104
47SGK2231.02670156
48SGK4941.02670156
49MST41.00519989
50CAMKK20.99363536
51MARK30.98846340
52CAMK2B0.98665086
53PRKCQ0.98435049
54IRAK20.97974332
55MARK10.97441768
56MARK20.96288305
57SIK30.95888080
58MAPKAPK50.95402409
59BRSK20.94225162
60UHMK10.92438121
61ZAK0.91117704
62TLK10.90909640
63CSNK1G10.90340600
64ROCK20.89641104
65NLK0.89490355
66CSNK1G20.87532182
67YES10.86888115
68CHUK0.85874704
69KIT0.85299317
70DYRK1A0.84496654
71IKBKB0.80755169
72DYRK30.80194790
73NTRK30.79583833
74DYRK20.79142136
75CAMK2D0.79027598
76PIK3CG0.77734620
77FES0.77071512
78GRK10.76124874
79BLK0.75683465
80PRKCE0.75237962
81ADRBK20.74494372
82SRPK10.70972341
83CDK190.70097572
84WEE10.69066191
85FGR0.67955088
86TAF10.67610064
87EIF2AK20.67415312
88RPS6KA50.66058387
89PRKCG0.65997691
90EPHA30.65901910
91MAP2K40.65801312
92TRPM70.64291841
93ERBB30.63738152
94MELK0.63246011
95CAMK2A0.62583174
96KSR10.62168705
97STK30.60885956
98MAPK70.58974130
99PIK3CA0.58606567
100ERBB20.57302451
101CAMK1G0.56711051
102MAP4K10.56447244
103TNK20.55654963
104NME10.55016139
105PRKG10.54930911
106GRK60.54590308
107MET0.53610323
108MAP3K130.52935094
109BTK0.52382543
110CDK90.52248713
111MATK0.51380499
112VRK10.51318396
113PAK30.51287548
114STK110.50475324
115ADRBK10.48931130
116SIK20.48148914
117RIPK40.47855149
118WNK30.47596294
119CDK50.47319423
120PLK20.47316938
121SGK10.46951533
122CDK80.46756056
123SYK0.46175115
124HIPK20.45375523
125CSNK1D0.44253662
126IKBKE0.43698473
127NTRK20.43585759
128DMPK0.43585553
129ITK0.43036528
130LYN0.42773028
131SGK20.42114105
132LCK0.40984033
133JAK10.40283236
134IRAK30.39012384
135FYN0.38234714
136TEC0.37800397
137CSNK1A10.35016622
138MAP3K60.34867831

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.60979792
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40589530
3Homologous recombination_Homo sapiens_hsa034402.21282487
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19107338
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17908996
6Ether lipid metabolism_Homo sapiens_hsa005652.14151747
7Protein export_Homo sapiens_hsa030602.08508200
8Axon guidance_Homo sapiens_hsa043601.93640833
9Nicotine addiction_Homo sapiens_hsa050331.88235475
10Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.87940627
11Nitrogen metabolism_Homo sapiens_hsa009101.82818340
12Serotonergic synapse_Homo sapiens_hsa047261.77585537
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76636126
14Sphingolipid metabolism_Homo sapiens_hsa006001.75516495
15RNA degradation_Homo sapiens_hsa030181.74300842
16Phototransduction_Homo sapiens_hsa047441.67884157
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60594281
18Morphine addiction_Homo sapiens_hsa050321.59455228
19Glutamatergic synapse_Homo sapiens_hsa047241.57188252
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56479757
21Steroid biosynthesis_Homo sapiens_hsa001001.54965635
22Autoimmune thyroid disease_Homo sapiens_hsa053201.54845624
23Caffeine metabolism_Homo sapiens_hsa002321.37769872
24GABAergic synapse_Homo sapiens_hsa047271.32784978
25Fatty acid elongation_Homo sapiens_hsa000621.31894088
26Circadian entrainment_Homo sapiens_hsa047131.29561139
27Taste transduction_Homo sapiens_hsa047421.27567420
28Regulation of autophagy_Homo sapiens_hsa041401.22201662
29Butanoate metabolism_Homo sapiens_hsa006501.21956152
30Measles_Homo sapiens_hsa051621.20108101
31Long-term depression_Homo sapiens_hsa047301.18877028
32Non-homologous end-joining_Homo sapiens_hsa034501.16992674
33Allograft rejection_Homo sapiens_hsa053301.15832501
34Primary immunodeficiency_Homo sapiens_hsa053401.10789128
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05768923
36T cell receptor signaling pathway_Homo sapiens_hsa046601.05327647
37Linoleic acid metabolism_Homo sapiens_hsa005911.03228855
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02814705
39Cocaine addiction_Homo sapiens_hsa050301.02770645
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.02240797
41Cholinergic synapse_Homo sapiens_hsa047251.01406491
42Graft-versus-host disease_Homo sapiens_hsa053321.00806488
43Basal transcription factors_Homo sapiens_hsa030220.99686567
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97489937
45Wnt signaling pathway_Homo sapiens_hsa043100.96901376
46Dopaminergic synapse_Homo sapiens_hsa047280.96839137
47Salivary secretion_Homo sapiens_hsa049700.96324592
48Rheumatoid arthritis_Homo sapiens_hsa053230.96234590
49Amphetamine addiction_Homo sapiens_hsa050310.95700034
50Ras signaling pathway_Homo sapiens_hsa040140.93465011
51Fanconi anemia pathway_Homo sapiens_hsa034600.93352742
52Renin secretion_Homo sapiens_hsa049240.92894116
53ABC transporters_Homo sapiens_hsa020100.91768265
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89370197
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.88759327
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85512226
57Calcium signaling pathway_Homo sapiens_hsa040200.83859101
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83129544
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82523471
60Ovarian steroidogenesis_Homo sapiens_hsa049130.81372762
61FoxO signaling pathway_Homo sapiens_hsa040680.80516259
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79925989
63cAMP signaling pathway_Homo sapiens_hsa040240.79860926
64Dorso-ventral axis formation_Homo sapiens_hsa043200.79585921
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79449933
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78244536
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77212791
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76821702
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76744554
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76114815
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76112435
72Renal cell carcinoma_Homo sapiens_hsa052110.75820302
73Arachidonic acid metabolism_Homo sapiens_hsa005900.75779189
74Long-term potentiation_Homo sapiens_hsa047200.75295132
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.74852153
76Pancreatic secretion_Homo sapiens_hsa049720.74380054
77Insulin secretion_Homo sapiens_hsa049110.74152682
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.73935193
79Herpes simplex infection_Homo sapiens_hsa051680.73458259
80Choline metabolism in cancer_Homo sapiens_hsa052310.72483220
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72129269
82Collecting duct acid secretion_Homo sapiens_hsa049660.70270498
83MAPK signaling pathway_Homo sapiens_hsa040100.70158233
84Hematopoietic cell lineage_Homo sapiens_hsa046400.70081812
85Oxidative phosphorylation_Homo sapiens_hsa001900.69570875
86Malaria_Homo sapiens_hsa051440.69019531
87Chemokine signaling pathway_Homo sapiens_hsa040620.68693132
88Hedgehog signaling pathway_Homo sapiens_hsa043400.68500254
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68339527
90African trypanosomiasis_Homo sapiens_hsa051430.67947449
91Prostate cancer_Homo sapiens_hsa052150.66805446
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66593089
93ErbB signaling pathway_Homo sapiens_hsa040120.66477357
94Basal cell carcinoma_Homo sapiens_hsa052170.66011995
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65156489
96Alcoholism_Homo sapiens_hsa050340.64921035
97Melanogenesis_Homo sapiens_hsa049160.64625127
98RNA polymerase_Homo sapiens_hsa030200.64533541
99Vibrio cholerae infection_Homo sapiens_hsa051100.63634686
100B cell receptor signaling pathway_Homo sapiens_hsa046620.63540645
101Type II diabetes mellitus_Homo sapiens_hsa049300.62954299
102Prolactin signaling pathway_Homo sapiens_hsa049170.62893307
103Alzheimers disease_Homo sapiens_hsa050100.61535582
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.60793523
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.59898658
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59470063
107Oxytocin signaling pathway_Homo sapiens_hsa049210.59363816
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58693499
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.58272513
110Tight junction_Homo sapiens_hsa045300.57928381
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57006561
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56800119
113Asthma_Homo sapiens_hsa053100.55506114
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55444602
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54731945
116mRNA surveillance pathway_Homo sapiens_hsa030150.54073356
117Selenocompound metabolism_Homo sapiens_hsa004500.53227450
118Gastric acid secretion_Homo sapiens_hsa049710.52807062
119Olfactory transduction_Homo sapiens_hsa047400.52614580
120ECM-receptor interaction_Homo sapiens_hsa045120.52254937
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52233689
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51308833
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49329187
124Type I diabetes mellitus_Homo sapiens_hsa049400.48500336
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48284810
126Peroxisome_Homo sapiens_hsa041460.47741413
127TNF signaling pathway_Homo sapiens_hsa046680.47424385
128TGF-beta signaling pathway_Homo sapiens_hsa043500.47348564
129Legionellosis_Homo sapiens_hsa051340.46479899
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46119168
131Circadian rhythm_Homo sapiens_hsa047100.45357877
132Oocyte meiosis_Homo sapiens_hsa041140.45270042
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44880103
134Rap1 signaling pathway_Homo sapiens_hsa040150.44081025
135Leishmaniasis_Homo sapiens_hsa051400.43611604
136RNA transport_Homo sapiens_hsa030130.42689487
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42603544
138p53 signaling pathway_Homo sapiens_hsa041150.40100154
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35251812
140Propanoate metabolism_Homo sapiens_hsa006400.34011189
141Tryptophan metabolism_Homo sapiens_hsa003800.33390950

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