ARID4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.71795392
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64944463
3negative regulation of cell killing (GO:0031342)4.52725035
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.52725035
5regulation of B cell receptor signaling pathway (GO:0050855)4.50922777
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.30381433
7positive regulation of gamma-delta T cell activation (GO:0046645)4.24032196
8behavioral response to nicotine (GO:0035095)4.22651671
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.07369092
10mast cell activation (GO:0045576)4.06224534
11neural tube formation (GO:0001841)3.94815519
12somite development (GO:0061053)3.91882629
13mast cell activation involved in immune response (GO:0002279)3.86576607
14mast cell degranulation (GO:0043303)3.86576607
15presynaptic membrane assembly (GO:0097105)3.85231734
16cellular extravasation (GO:0045123)3.83992034
17establishment of protein localization to Golgi (GO:0072600)3.81699475
18T cell migration (GO:0072678)3.78599373
19neuron fate determination (GO:0048664)3.77799217
20protein targeting to Golgi (GO:0000042)3.69530742
21nucleobase catabolic process (GO:0046113)3.66792567
22presynaptic membrane organization (GO:0097090)3.63326369
23neuron cell-cell adhesion (GO:0007158)3.59733431
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.59565163
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.59565163
26regulation of translation, ncRNA-mediated (GO:0045974)3.59565163
27gamma-aminobutyric acid transport (GO:0015812)3.53665249
28central nervous system projection neuron axonogenesis (GO:0021952)3.50553395
29cerebral cortex radially oriented cell migration (GO:0021799)3.49006703
30retrograde transport, vesicle recycling within Golgi (GO:0000301)3.46915686
31mature B cell differentiation (GO:0002335)3.46897671
32negative T cell selection (GO:0043383)3.46859863
33neutrophil activation involved in immune response (GO:0002283)3.45733341
34negative thymic T cell selection (GO:0045060)3.41725502
35neutrophil activation (GO:0042119)3.40082086
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.34831753
37nonmotile primary cilium assembly (GO:0035058)3.33415341
38retinal cone cell development (GO:0046549)3.32296199
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.27745964
40B cell receptor signaling pathway (GO:0050853)3.24894412
41regulation of gamma-delta T cell differentiation (GO:0045586)3.24183143
42germinal center formation (GO:0002467)3.23122910
43* histone H3-K4 trimethylation (GO:0080182)3.22773511
44axoneme assembly (GO:0035082)3.22151929
45respiratory burst (GO:0045730)3.19848670
46regulation of gamma-delta T cell activation (GO:0046643)3.19646528
47ionotropic glutamate receptor signaling pathway (GO:0035235)3.18285961
48epithelial cilium movement (GO:0003351)3.17456167
49centriole replication (GO:0007099)3.17313350
50interferon-gamma production (GO:0032609)3.15408154
51cellular response to interleukin-15 (GO:0071350)3.15119333
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.11768269
53myeloid cell activation involved in immune response (GO:0002275)3.10643054
54leukocyte degranulation (GO:0043299)3.10352092
55response to type I interferon (GO:0034340)3.09895777
56regulation of alpha-beta T cell proliferation (GO:0046640)3.09618348
57granulocyte activation (GO:0036230)3.09518141
58interferon-gamma-mediated signaling pathway (GO:0060333)3.09214379
59leukocyte aggregation (GO:0070486)3.08889369
60cellular response to type I interferon (GO:0071357)3.07970992
61type I interferon signaling pathway (GO:0060337)3.07970992
62neuronal action potential (GO:0019228)3.07543676
63postsynaptic membrane organization (GO:0001941)3.06158982
64microglial cell activation (GO:0001774)3.05765760
65dendritic cell chemotaxis (GO:0002407)3.05413018
66glutamate receptor signaling pathway (GO:0007215)3.04527812
67protein polyglutamylation (GO:0018095)3.03963575
68dendritic cell migration (GO:0036336)3.03537826
69adaptation of signaling pathway (GO:0023058)3.02612428
70positive T cell selection (GO:0043368)3.01552050
71myeloid dendritic cell activation (GO:0001773)3.01224073
72L-fucose catabolic process (GO:0042355)2.99168182
73fucose catabolic process (GO:0019317)2.99168182
74L-fucose metabolic process (GO:0042354)2.99168182
75detection of light stimulus involved in sensory perception (GO:0050962)2.95519364
76detection of light stimulus involved in visual perception (GO:0050908)2.95519364
77T-helper cell differentiation (GO:0042093)2.92624346
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.92624346
79mechanosensory behavior (GO:0007638)2.92560816
80central nervous system neuron axonogenesis (GO:0021955)2.92407501
81regulation of T cell tolerance induction (GO:0002664)2.92071704
82positive regulation of interleukin-2 production (GO:0032743)2.91389238
83forebrain neuron differentiation (GO:0021879)2.91360237
84positive regulation of alpha-beta T cell proliferation (GO:0046641)2.90940110
85T cell selection (GO:0045058)2.90796992
86regulation of B cell differentiation (GO:0045577)2.90155428
87NIK/NF-kappaB signaling (GO:0038061)2.89647953
88positive thymic T cell selection (GO:0045059)2.89444880
89positive regulation by symbiont of host defense response (GO:0052509)2.89054947
90modulation by symbiont of host defense response (GO:0052031)2.89054947
91modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.89054947
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.89054947
93positive regulation by organism of defense response of other organism involved in symbiotic interact2.89054947
94modulation by symbiont of host immune response (GO:0052553)2.89054947
95startle response (GO:0001964)2.88965690
96tolerance induction (GO:0002507)2.86513452
97immunoglobulin mediated immune response (GO:0016064)2.86308432
98regulation of regulatory T cell differentiation (GO:0045589)2.85823689
99alpha-beta T cell activation (GO:0046631)2.85678254
100antigen processing and presentation of endogenous antigen (GO:0019883)2.85666013
101response to muramyl dipeptide (GO:0032495)2.83434027
102protein localization to Golgi apparatus (GO:0034067)2.82594653
103positive regulation of interferon-alpha production (GO:0032727)2.80811361
104CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.80583135
105regulation of mast cell activation (GO:0033003)2.80309087
106auditory behavior (GO:0031223)2.79761239
107G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79429970
108neuronal action potential propagation (GO:0019227)2.78973077
109response to peptidoglycan (GO:0032494)2.78696016
110positive regulation of oligodendrocyte differentiation (GO:0048714)2.77451039
111limb bud formation (GO:0060174)2.76952255
112positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.76740843
113regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.76740843
114B cell homeostasis (GO:0001782)2.76031241
115cilium morphogenesis (GO:0060271)2.75326516
116olfactory bulb development (GO:0021772)2.74374602
117response to interleukin-15 (GO:0070672)2.73835088
118synaptic transmission, glutamatergic (GO:0035249)2.73439785
119lymph node development (GO:0048535)2.73072912
120mature B cell differentiation involved in immune response (GO:0002313)2.72573645
121alpha-beta T cell differentiation (GO:0046632)2.72516091
122protein localization to synapse (GO:0035418)2.72450111
123neurotransmitter-gated ion channel clustering (GO:0072578)2.72153616
124negative regulation of T cell mediated immunity (GO:0002710)2.71975149
125regulation of T cell receptor signaling pathway (GO:0050856)2.71248202
126regulation of interferon-beta biosynthetic process (GO:0045357)2.70699127
127regulation of interferon-alpha production (GO:0032647)2.69391148
128positive regulation of interleukin-12 production (GO:0032735)2.68805330
129axonal fasciculation (GO:0007413)2.68751108
130positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.67132349
131regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.67132349
132regulation of meiosis I (GO:0060631)2.67066347
133neuron recognition (GO:0008038)2.66682199
134defense response to protozoan (GO:0042832)2.66353591
135photoreceptor cell development (GO:0042461)2.66128253
136dendritic spine morphogenesis (GO:0060997)2.65022532
137regulation of interleukin-2 biosynthetic process (GO:0045076)2.65004458
138myeloid dendritic cell differentiation (GO:0043011)2.64907551
139cellular response to interferon-beta (GO:0035458)2.64905908
140serotonin metabolic process (GO:0042428)2.63991052
141protein K11-linked deubiquitination (GO:0035871)2.63467735
142myeloid leukocyte activation (GO:0002274)2.63464683
143antigen receptor-mediated signaling pathway (GO:0050851)2.62912661
144positive regulation of B cell differentiation (GO:0045579)2.62839026
145hepatocyte apoptotic process (GO:0097284)2.62480779
146intraciliary transport (GO:0042073)2.62416888
147glycosphingolipid biosynthetic process (GO:0006688)2.61976143
148positive regulation of antigen processing and presentation (GO:0002579)2.60845437
149cilium organization (GO:0044782)2.60403539
150positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.59653044
151positive regulation of granulocyte differentiation (GO:0030854)2.58435796
152cilium movement (GO:0003341)2.58183164
153vocalization behavior (GO:0071625)2.58020620
154regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57698965
155negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.57037859
156synapse assembly (GO:0007416)2.56899731
157regulation of mast cell degranulation (GO:0043304)2.56810289
158adult walking behavior (GO:0007628)2.56344797
159positive regulation of mast cell activation (GO:0033005)2.56342563
160CD4-positive, alpha-beta T cell activation (GO:0035710)2.55803089
161positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.55373529
162thymic T cell selection (GO:0045061)2.55111268
163cilium assembly (GO:0042384)2.54733701
164activated T cell proliferation (GO:0050798)2.54495394
165regulation of mast cell activation involved in immune response (GO:0033006)2.52948970
166eye photoreceptor cell development (GO:0042462)2.52786023
167alpha-beta T cell differentiation involved in immune response (GO:0002293)2.52694579
168alpha-beta T cell activation involved in immune response (GO:0002287)2.52694579
169T cell differentiation involved in immune response (GO:0002292)2.52694579
170piRNA metabolic process (GO:0034587)2.52289030
171protein localization to cilium (GO:0061512)2.50787738
172response to protozoan (GO:0001562)2.50517934
173antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49977850
174antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.49977850
175positive regulation of neurological system process (GO:0031646)2.48302320
176substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.45019376
177substrate-independent telencephalic tangential migration (GO:0021826)2.45019376
178transmission of nerve impulse (GO:0019226)2.44988397
179spinal cord motor neuron differentiation (GO:0021522)2.44051839
180regulation of telomere maintenance (GO:0032204)2.43162241
181neuron-neuron synaptic transmission (GO:0007270)2.42417693
182cilium or flagellum-dependent cell motility (GO:0001539)2.40568273
183microtubule anchoring (GO:0034453)2.40032263
184monoubiquitinated protein deubiquitination (GO:0035520)2.39978150
185regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.39470086
186dendrite morphogenesis (GO:0048813)2.38925151
187indolalkylamine metabolic process (GO:0006586)2.37581964
188photoreceptor cell maintenance (GO:0045494)2.37314505
189positive regulation of microtubule polymerization (GO:0031116)2.36949061
190regulation of action potential (GO:0098900)2.36489431
191dentate gyrus development (GO:0021542)2.36376501
192inner ear receptor stereocilium organization (GO:0060122)2.36332809
193regulation of cilium movement (GO:0003352)2.36273355
194positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.35478118
195mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.35478118
196positive regulation of synapse assembly (GO:0051965)2.33580055
197seminiferous tubule development (GO:0072520)2.33006024
198kidney morphogenesis (GO:0060993)2.32432792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.27796028
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.19504639
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.95421003
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.76792215
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.65825942
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.28284205
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.07568188
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.01757953
9ZNF274_21170338_ChIP-Seq_K562_Hela2.69606172
10* IRF8_27001747_Chip-Seq_BMDM_Mouse2.64565308
11VDR_22108803_ChIP-Seq_LS180_Human2.59789083
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.53796264
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50078847
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42162708
15RUNX_20019798_ChIP-Seq_JUKART_Human2.37494173
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27661335
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16961614
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.16856327
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14783178
20SCL_19346495_ChIP-Seq_HPC-7_Human2.07907002
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05727824
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05358030
23GBX2_23144817_ChIP-Seq_PC3_Human2.04953928
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03246275
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02294477
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.96991278
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.93549764
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88873136
29* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85898150
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78750087
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76586936
32TAF15_26573619_Chip-Seq_HEK293_Human1.76527554
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76288835
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75733660
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72427835
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.68197046
37REST_21632747_ChIP-Seq_MESCs_Mouse1.66457404
38BCAT_22108803_ChIP-Seq_LS180_Human1.63213199
39* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62500133
40* STAT3_23295773_ChIP-Seq_U87_Human1.61797646
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60233837
42IGF1R_20145208_ChIP-Seq_DFB_Human1.60213070
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.59663100
44RNF2_27304074_Chip-Seq_NSC_Mouse1.58474002
45CBP_20019798_ChIP-Seq_JUKART_Human1.56009686
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56009686
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53201018
48MYB_26560356_Chip-Seq_TH2_Human1.53148271
49* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52349185
50P300_19829295_ChIP-Seq_ESCs_Human1.52065390
51* TCF4_23295773_ChIP-Seq_U87_Human1.49221727
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.48413130
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47866497
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46259913
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45679969
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44848801
57EZH2_22144423_ChIP-Seq_EOC_Human1.43178854
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42622825
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.41694609
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41571097
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40908093
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.39630546
63AR_21572438_ChIP-Seq_LNCaP_Human1.38684827
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.38353132
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38304553
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36951030
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.36367658
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35954416
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.34780808
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33933320
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33669817
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.32921674
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32642354
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32267916
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31307565
76RUNX2_22187159_ChIP-Seq_PCA_Human1.31102978
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30898751
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30205060
79* SPI1_23547873_ChIP-Seq_NB4_Human1.29114578
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.26544556
81EWS_26573619_Chip-Seq_HEK293_Human1.26337857
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25930832
83MYB_26560356_Chip-Seq_TH1_Human1.25757055
84P53_22387025_ChIP-Seq_ESCs_Mouse1.25506433
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.25492946
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25336023
87NMYC_18555785_Chip-Seq_ESCs_Mouse1.23965862
88* VDR_24787735_ChIP-Seq_THP-1_Human1.23729084
89FUS_26573619_Chip-Seq_HEK293_Human1.22403379
90TCF4_22108803_ChIP-Seq_LS180_Human1.21566860
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19780576
92TP53_16413492_ChIP-PET_HCT116_Human1.19675642
93SMAD4_21799915_ChIP-Seq_A2780_Human1.19228019
94RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19209978
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.18621967
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.18139439
97P300_18555785_Chip-Seq_ESCs_Mouse1.17842019
98JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17293509
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16638400
100PU_27001747_Chip-Seq_BMDM_Mouse1.15988827
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14844174
102RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14714249
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13315114
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12695086
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.11468394
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.11442435
107TP63_19390658_ChIP-ChIP_HaCaT_Human1.10057193
108EGR1_19374776_ChIP-ChIP_THP-1_Human1.10042018
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09264726
110PU1_27457419_Chip-Seq_LIVER_Mouse1.09017836
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.08966532
112SPI1_23127762_ChIP-Seq_K562_Human1.07885622
113TP53_22573176_ChIP-Seq_HFKS_Human1.07122541
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06005040
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.05423879
116* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05072430
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04752453
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04181510
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03926642
120REST_18959480_ChIP-ChIP_MESCs_Mouse1.03315125
121* KDM2B_26808549_Chip-Seq_REH_Human1.03290602
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02935419
123SOX2_19829295_ChIP-Seq_ESCs_Human1.02773166
124NANOG_19829295_ChIP-Seq_ESCs_Human1.02773166
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02740109
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02731163
127GATA3_27048872_Chip-Seq_THYMUS_Human1.02026177
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01505019
129PRDM14_20953172_ChIP-Seq_ESCs_Human1.01468991
130CTCF_18555785_Chip-Seq_ESCs_Mouse1.01163599
131ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99433499
132ZFX_18555785_Chip-Seq_ESCs_Mouse0.99053741
133JUN_21703547_ChIP-Seq_K562_Human0.98465439
134POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97949921
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97942754
136IRF1_19129219_ChIP-ChIP_H3396_Human0.97510914
137ARNT_22903824_ChIP-Seq_MCF-7_Human0.97308380
138RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97298171
139AR_25329375_ChIP-Seq_VCAP_Human0.97189441
140ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96987345
141KLF4_18555785_Chip-Seq_ESCs_Mouse0.96875288
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96366242
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96366242
144ER_23166858_ChIP-Seq_MCF-7_Human0.96196858
145LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95933727
146EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95779420
147SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93795970
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93501186
149GATA3_26560356_Chip-Seq_TH2_Human0.93331574
150RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91855857
151UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91560330
152CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91344180
153MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91190519
154* RUNX1_22412390_ChIP-Seq_EML_Mouse0.90500805
155MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90415953

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.36273054
2MP0005671_abnormal_response_to3.70764372
3* MP0008877_abnormal_DNA_methylation3.54166723
4MP0002148_abnormal_hypersensitivity_rea3.11380390
5MP0001790_abnormal_immune_system3.08239854
6MP0005387_immune_system_phenotype3.08239854
7MP0001800_abnormal_humoral_immune3.02366474
8MP0009785_altered_susceptibility_to2.89369353
9MP0005000_abnormal_immune_tolerance2.85885598
10MP0003436_decreased_susceptibility_to2.71271992
11MP0002452_abnormal_antigen_presenting2.68297624
12MP0000685_abnormal_immune_system2.65298616
13MP0000569_abnormal_digit_pigmentation2.65073571
14MP0002723_abnormal_immune_serum2.60709690
15MP0005025_abnormal_response_to2.53258284
16MP0001819_abnormal_immune_cell2.53085233
17MP0003763_abnormal_thymus_physiology2.52456537
18MP0002420_abnormal_adaptive_immunity2.51063304
19MP0002419_abnormal_innate_immunity2.48105719
20MP0004510_myositis2.33071607
21MP0002166_altered_tumor_susceptibility2.30634124
22MP0003724_increased_susceptibility_to2.21948519
23MP0005174_abnormal_tail_pigmentation2.18257491
24MP0002272_abnormal_nervous_system2.10357937
25MP0004142_abnormal_muscle_tone2.10170322
26MP0002006_tumorigenesis2.09899238
27* MP0002398_abnormal_bone_marrow2.05799625
28* MP0003121_genomic_imprinting2.02145021
29MP0000778_abnormal_nervous_system2.01958131
30MP0005551_abnormal_eye_electrophysiolog2.01080444
31MP0000015_abnormal_ear_pigmentation1.98254495
32MP0001486_abnormal_startle_reflex1.98065857
33MP0006276_abnormal_autonomic_nervous1.96980197
34* MP0000716_abnormal_immune_system1.95195898
35MP0005310_abnormal_salivary_gland1.93940191
36MP0003635_abnormal_synaptic_transmissio1.93368791
37MP0002396_abnormal_hematopoietic_system1.92455163
38MP0005409_darkened_coat_color1.89647595
39MP0003303_peritoneal_inflammation1.88874424
40MP0002009_preneoplasia1.88370447
41MP0006082_CNS_inflammation1.88115726
42MP0005464_abnormal_platelet_physiology1.85209768
43MP0004885_abnormal_endolymph1.84121260
44MP0008057_abnormal_DNA_replication1.83759599
45MP0009046_muscle_twitch1.83604970
46MP0010155_abnormal_intestine_physiology1.76102340
47MP0002405_respiratory_system_inflammati1.75997797
48MP0001188_hyperpigmentation1.75353898
49MP0001853_heart_inflammation1.74428577
50MP0002063_abnormal_learning/memory/cond1.72395965
51MP0008789_abnormal_olfactory_epithelium1.71193700
52* MP0003122_maternal_imprinting1.61625162
53* MP0000689_abnormal_spleen_morphology1.59786632
54MP0005394_taste/olfaction_phenotype1.58728640
55MP0005499_abnormal_olfactory_system1.58728640
56MP0001984_abnormal_olfaction1.57585260
57MP0002064_seizures1.56675480
58MP0004742_abnormal_vestibular_system1.55961396
59MP0003195_calcinosis1.55790552
60* MP0002722_abnormal_immune_system1.52928113
61MP0005423_abnormal_somatic_nervous1.52409045
62MP0003880_abnormal_central_pattern1.52234905
63MP0002734_abnormal_mechanical_nocicepti1.51697832
64MP0005646_abnormal_pituitary_gland1.50984220
65MP0002067_abnormal_sensory_capabilities1.49538195
66MP0006292_abnormal_olfactory_placode1.48948807
67MP0001845_abnormal_inflammatory_respons1.48886209
68MP0004133_heterotaxia1.47928003
69MP0004859_abnormal_synaptic_plasticity1.47834236
70MP0000703_abnormal_thymus_morphology1.46835652
71* MP0002429_abnormal_blood_cell1.46621745
72MP0002557_abnormal_social/conspecific_i1.45357460
73MP0004043_abnormal_pH_regulation1.43981982
74MP0000631_abnormal_neuroendocrine_gland1.43933701
75MP0001970_abnormal_pain_threshold1.43104558
76MP0002277_abnormal_respiratory_mucosa1.41159018
77MP0005386_behavior/neurological_phenoty1.40466811
78MP0004924_abnormal_behavior1.40466811
79MP0001986_abnormal_taste_sensitivity1.40228355
80MP0003866_abnormal_defecation1.39879178
81MP0006072_abnormal_retinal_apoptosis1.39848542
82MP0005187_abnormal_penis_morphology1.39075444
83MP0005075_abnormal_melanosome_morpholog1.36332912
84MP0002733_abnormal_thermal_nociception1.36252479
85MP0002138_abnormal_hepatobiliary_system1.35036068
86* MP0004808_abnormal_hematopoietic_stem1.30497062
87MP0003890_abnormal_embryonic-extraembry1.26779602
88MP0001533_abnormal_skeleton_physiology1.26616046
89MP0005253_abnormal_eye_physiology1.23948552
90MP0001529_abnormal_vocalization1.22771045
91MP0001873_stomach_inflammation1.16536415
92MP0001545_abnormal_hematopoietic_system1.11453718
93MP0005397_hematopoietic_system_phenotyp1.11453718
94MP0002095_abnormal_skin_pigmentation1.11033007
95MP0003183_abnormal_peptide_metabolism1.10296693
96MP0002653_abnormal_ependyma_morphology1.09936714
97MP0000427_abnormal_hair_cycle1.09293083
98MP0004270_analgesia1.08682229
99MP0002102_abnormal_ear_morphology1.07573318
100MP0005379_endocrine/exocrine_gland_phen1.06343074
101MP0000955_abnormal_spinal_cord1.05890825
102MP0002163_abnormal_gland_morphology1.05537701
103MP0009333_abnormal_splenocyte_physiolog1.05316834
104MP0001485_abnormal_pinna_reflex1.05052206
105MP0005084_abnormal_gallbladder_morpholo1.04158719
106MP0001851_eye_inflammation1.03381534
107MP0002184_abnormal_innervation1.02993644
108MP0002882_abnormal_neuron_morphology1.02924216
109MP0004947_skin_inflammation1.01433917
110MP0002752_abnormal_somatic_nervous1.01304844
111MP0002928_abnormal_bile_duct1.01261818
112MP0003300_gastrointestinal_ulcer1.00437074
113MP0009764_decreased_sensitivity_to0.98653089
114MP0003828_pulmonary_edema0.97976700
115MP0002933_joint_inflammation0.97505637
116MP0002751_abnormal_autonomic_nervous0.97126652
117MP0003938_abnormal_ear_development0.96730302
118MP0002234_abnormal_pharynx_morphology0.95130680
119MP0008469_abnormal_protein_level0.95101237
120MP0000465_gastrointestinal_hemorrhage0.93434170
121MP0002998_abnormal_bone_remodeling0.92114986
122MP0008872_abnormal_physiological_respon0.90255092
123MP0005195_abnormal_posterior_eye0.89655693
124MP0004381_abnormal_hair_follicle0.88825048
125MP0002152_abnormal_brain_morphology0.87820351
126MP0004811_abnormal_neuron_physiology0.87642187
127MP0000490_abnormal_crypts_of0.87457109
128* MP0003787_abnormal_imprinting0.86186069
129MP0003698_abnormal_male_reproductive0.84323087
130MP0000049_abnormal_middle_ear0.83523768
131MP0003448_altered_tumor_morphology0.83034731
132MP0002822_catalepsy0.82769689
133MP0000647_abnormal_sebaceous_gland0.82105712
134MP0001501_abnormal_sleep_pattern0.81164006
135MP0003633_abnormal_nervous_system0.80792644
136MP0002909_abnormal_adrenal_gland0.80472723
137MP0002735_abnormal_chemical_nociception0.79974732
138MP0000026_abnormal_inner_ear0.79889321
139* MP0002066_abnormal_motor_capabilities/c0.78139697
140MP0005171_absent_coat_pigmentation0.78116895
141MP0001963_abnormal_hearing_physiology0.75863940
142MP0002229_neurodegeneration0.73935166
143MP0001919_abnormal_reproductive_system0.73156114
144MP0001324_abnormal_eye_pigmentation0.73040784
145MP0009745_abnormal_behavioral_response0.71285708
146MP0004147_increased_porphyrin_level0.70922912
147* MP0001929_abnormal_gametogenesis0.70140017
148MP0003631_nervous_system_phenotype0.69017183
149MP0008569_lethality_at_weaning0.68876874
150MP0001905_abnormal_dopamine_level0.68847050
151MP0005248_abnormal_Harderian_gland0.68738876
152MP0000858_altered_metastatic_potential0.67845333
153MP0002069_abnormal_eating/drinking_beha0.65955844
154MP0008058_abnormal_DNA_repair0.65250938
155MP0010386_abnormal_urinary_bladder0.64815022
156MP0000343_altered_response_to0.62348287
157MP0002638_abnormal_pupillary_reflex0.61962777
158MP0002254_reproductive_system_inflammat0.61952295
159MP0001502_abnormal_circadian_rhythm0.61475780
160MP0009278_abnormal_bone_marrow0.61191471
161MP0001440_abnormal_grooming_behavior0.59737647
162MP0005645_abnormal_hypothalamus_physiol0.59505726
163MP0009763_increased_sensitivity_to0.57501680
164MP0002876_abnormal_thyroid_physiology0.57432926
165MP0008995_early_reproductive_senescence0.56656605
166MP0005390_skeleton_phenotype0.55027213
167MP0004883_abnormal_blood_vessel0.54845965
168MP0001968_abnormal_touch/_nociception0.53568556
169MP0002736_abnormal_nociception_after0.51046036
170MP0003136_yellow_coat_color0.51012218
171MP0002572_abnormal_emotion/affect_behav0.48661305
172MP0002693_abnormal_pancreas_physiology0.46681873

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.82704469
2Recurrent bacterial skin infections (HP:0005406)4.33214438
3Eczematoid dermatitis (HP:0000976)4.13438464
4Hyperventilation (HP:0002883)4.08716370
5Recurrent fungal infections (HP:0002841)3.99207105
6Chronic mucocutaneous candidiasis (HP:0002728)3.94873294
7Recurrent cutaneous fungal infections (HP:0011370)3.94873294
8Agammaglobulinemia (HP:0004432)3.85549096
9Pancreatic cysts (HP:0001737)3.85469370
10Prostate neoplasm (HP:0100787)3.66130504
11Pancreatic fibrosis (HP:0100732)3.66061894
12Abnormality of midbrain morphology (HP:0002418)3.62027950
13Molar tooth sign on MRI (HP:0002419)3.62027950
14Abnormality of the fingertips (HP:0001211)3.57557229
15Focal motor seizures (HP:0011153)3.49367056
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.46443152
17Panhypogammaglobulinemia (HP:0003139)3.45185534
18Recurrent viral infections (HP:0004429)3.44296909
19True hermaphroditism (HP:0010459)3.42495244
20Chronic obstructive pulmonary disease (HP:0006510)3.38660248
21Obstructive lung disease (HP:0006536)3.38660248
22Optic neuritis (HP:0100653)3.36824062
23Retrobulbar optic neuritis (HP:0100654)3.36824062
24Recurrent skin infections (HP:0001581)3.32630298
25Thyroiditis (HP:0100646)3.31230757
26Medial flaring of the eyebrow (HP:0010747)3.30662929
27Meningitis (HP:0001287)3.27748601
28Mediastinal lymphadenopathy (HP:0100721)3.26773364
29Myositis (HP:0100614)3.25996302
30Vasculitis (HP:0002633)3.13114149
31Progressive cerebellar ataxia (HP:0002073)3.11006473
32Nephronophthisis (HP:0000090)3.09994786
33Abnormality of the prostate (HP:0008775)3.08604698
34Gait imbalance (HP:0002141)3.04847211
35IgM deficiency (HP:0002850)2.99429046
36Focal seizures (HP:0007359)2.99255638
37Recurrent gram-negative bacterial infections (HP:0005420)2.91272783
38Elevated erythrocyte sedimentation rate (HP:0003565)2.89985446
39Volvulus (HP:0002580)2.87641206
40Drooling (HP:0002307)2.87076353
41Atonic seizures (HP:0010819)2.81227263
42Congenital stationary night blindness (HP:0007642)2.80664490
43Chronic otitis media (HP:0000389)2.80074328
44Stomatitis (HP:0010280)2.79117211
45Genetic anticipation (HP:0003743)2.78553763
46Orchitis (HP:0100796)2.77122853
47Abnormality of T cell number (HP:0011839)2.72896775
48Broad-based gait (HP:0002136)2.72246745
49Excessive salivation (HP:0003781)2.71667601
50Abnormality of the renal medulla (HP:0100957)2.71382597
51Congenital primary aphakia (HP:0007707)2.71163826
52Limb dystonia (HP:0002451)2.69410090
53Lip pit (HP:0100267)2.68206131
54T lymphocytopenia (HP:0005403)2.67429593
55Chronic hepatic failure (HP:0100626)2.64844471
56Chronic diarrhea (HP:0002028)2.60711038
57Colitis (HP:0002583)2.60560501
58Abnormal rod and cone electroretinograms (HP:0008323)2.60290540
59Increased IgM level (HP:0003496)2.60144581
60Inflammation of the large intestine (HP:0002037)2.59683139
61Severe combined immunodeficiency (HP:0004430)2.58082711
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.55573213
63Absent speech (HP:0001344)2.55421405
64Leukocytosis (HP:0001974)2.54681450
65Abnormal hair whorl (HP:0010721)2.53867714
66Chromsome breakage (HP:0040012)2.53561396
67Pulmonary infiltrates (HP:0002113)2.52918384
68Nephrogenic diabetes insipidus (HP:0009806)2.52725747
69Oligodactyly (hands) (HP:0001180)2.52626638
70Encephalitis (HP:0002383)2.52495435
71Abnormality of eosinophils (HP:0001879)2.51912090
72Dialeptic seizures (HP:0011146)2.51457286
73IgG deficiency (HP:0004315)2.50878224
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49706796
75Protruding tongue (HP:0010808)2.47463908
76Eosinophilia (HP:0001880)2.47132216
77Gaze-evoked nystagmus (HP:0000640)2.46518438
78Cellulitis (HP:0100658)2.45912204
79Recurrent bronchitis (HP:0002837)2.45733374
80Pustule (HP:0200039)2.45701999
81Lissencephaly (HP:0001339)2.45125832
82Abnormality of the labia minora (HP:0012880)2.44991182
83Recurrent pneumonia (HP:0006532)2.43435373
84Abnormality of the renal cortex (HP:0011035)2.42129505
85Abnormality of macrophages (HP:0004311)2.40598165
86Prolonged bleeding time (HP:0003010)2.40270884
87Degeneration of the lateral corticospinal tracts (HP:0002314)2.39350858
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39350858
89Abnormality of T cells (HP:0002843)2.38639871
90Chronic sinusitis (HP:0011109)2.38597284
91Genital tract atresia (HP:0001827)2.37025117
92Keratoconjunctivitis sicca (HP:0001097)2.36878419
93Gastrointestinal stroma tumor (HP:0100723)2.36281946
94Lymphopenia (HP:0001888)2.35733578
95Pachygyria (HP:0001302)2.31753831
96Type II lissencephaly (HP:0007260)2.30413801
97Spontaneous hematomas (HP:0007420)2.29690049
98Epileptic encephalopathy (HP:0200134)2.29298126
99Hepatoblastoma (HP:0002884)2.29271301
100Cystic liver disease (HP:0006706)2.28101329
101Recurrent sinusitis (HP:0011108)2.28095628
102Gastrointestinal inflammation (HP:0004386)2.27510378
103Attenuation of retinal blood vessels (HP:0007843)2.25514700
104Gingivitis (HP:0000230)2.24222717
105Vaginal atresia (HP:0000148)2.23855597
106Colon cancer (HP:0003003)2.22884276
107B lymphocytopenia (HP:0010976)2.21706006
108Abnormality of B cell number (HP:0010975)2.21706006
109Granulocytopenia (HP:0001913)2.19908433
110Hypochromic microcytic anemia (HP:0004840)2.19638766
111Abolished electroretinogram (ERG) (HP:0000550)2.19062296
112Arterial thrombosis (HP:0004420)2.18832434
113Polyphagia (HP:0002591)2.18585272
114Keratoconjunctivitis (HP:0001096)2.18379776
115Periodontitis (HP:0000704)2.18279496
116Abnormality of cells of the lymphoid lineage (HP:0012140)2.18202400
117Recurrent lower respiratory tract infections (HP:0002783)2.15372051
118Basal ganglia calcification (HP:0002135)2.14695127
119Generalized hypopigmentation of hair (HP:0011358)2.14346888
120Hypothermia (HP:0002045)2.14137518
121Autoimmune hemolytic anemia (HP:0001890)2.13863000
122Absent frontal sinuses (HP:0002688)2.13722004
123Inability to walk (HP:0002540)2.13082570
124Thyroid-stimulating hormone excess (HP:0002925)2.12839096
125Autoimmune thrombocytopenia (HP:0001973)2.09599826
126Poor coordination (HP:0002370)2.08869176
127Hemoptysis (HP:0002105)2.08142754
128Abnormality of the corticospinal tract (HP:0002492)2.06454089
129Anencephaly (HP:0002323)2.05996994
130Acute myeloid leukemia (HP:0004808)2.04920513
131Tented upper lip vermilion (HP:0010804)2.04816502
132Absence seizures (HP:0002121)2.04184358
133Febrile seizures (HP:0002373)2.03944927
134Optic nerve hypoplasia (HP:0000609)2.03319118
135Papillary thyroid carcinoma (HP:0002895)2.02722671
136Fair hair (HP:0002286)2.01761589
137Dyskinesia (HP:0100660)2.01251295
138Hemiparesis (HP:0001269)1.99665596
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.99331737
140Renal cortical cysts (HP:0000803)1.98936280
141Amyotrophic lateral sclerosis (HP:0007354)1.98581387
142Stomach cancer (HP:0012126)1.97468722
143Increased neuronal autofluorescent lipopigment (HP:0002074)1.96990670
144Combined immunodeficiency (HP:0005387)1.96801959
145Abnormality of T cell physiology (HP:0011840)1.96418673
146Bony spicule pigmentary retinopathy (HP:0007737)1.94639709
147White forelock (HP:0002211)1.94421765
148Epistaxis (HP:0000421)1.93718980
149Abnormal ciliary motility (HP:0012262)1.92964483
150Agitation (HP:0000713)1.92724275
151Narrow forehead (HP:0000341)1.92064876
152Decreased central vision (HP:0007663)1.91694314
153Widely spaced teeth (HP:0000687)1.91385790
154Absent/shortened dynein arms (HP:0200106)1.90888923
155Dynein arm defect of respiratory motile cilia (HP:0012255)1.90888923
156Agnosia (HP:0010524)1.90885872
157Postaxial hand polydactyly (HP:0001162)1.90819908
158Congenital hepatic fibrosis (HP:0002612)1.90321490
159Cheilitis (HP:0100825)1.87535901
160Petechiae (HP:0000967)1.86751414
161Osteomyelitis (HP:0002754)1.86532370
162Abnormality of male internal genitalia (HP:0000022)1.86025541
163Progressive inability to walk (HP:0002505)1.85896991
164Increased IgE level (HP:0003212)1.85731568
165Specific learning disability (HP:0001328)1.85112864
166Abnormal respiratory motile cilium morphology (HP:0005938)1.83953143
167Abnormal respiratory epithelium morphology (HP:0012253)1.83953143
168Vacuolated lymphocytes (HP:0001922)1.82426778
169Growth hormone deficiency (HP:0000824)1.82194518
170Patchy hypopigmentation of hair (HP:0011365)1.81221444
171Lymphoma (HP:0002665)1.81041286
172Postaxial foot polydactyly (HP:0001830)1.80425609
173Aplasia cutis congenita (HP:0001057)1.80089477
174Aplasia/Hypoplasia of the tibia (HP:0005772)1.80021770
175Clubbing of toes (HP:0100760)1.79785869
176Broad alveolar ridges (HP:0000187)1.79785685
177Systemic lupus erythematosus (HP:0002725)1.78439991
178Neoplasm of the tracheobronchial system (HP:0100552)1.78139659
179Hypergammaglobulinemia (HP:0010702)1.77317130
180Sclerocornea (HP:0000647)1.76300826
181Aplasia/Hypoplasia of the sternum (HP:0006714)1.75793051
182Pendular nystagmus (HP:0012043)1.75603478
183Sepsis (HP:0100806)1.75510646
184Abnormality of the nasal septum (HP:0000419)1.74726580
185Median cleft lip (HP:0000161)1.74288462
186Male pseudohermaphroditism (HP:0000037)1.72483909
187Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71868371
188Inappropriate behavior (HP:0000719)1.68408669
189Neoplasm of the oral cavity (HP:0100649)1.67756976
190Truncal obesity (HP:0001956)1.67348001
191Abnormal drinking behavior (HP:0030082)1.67331349
192Polydipsia (HP:0001959)1.67331349
193Myokymia (HP:0002411)1.66291395
194Short foot (HP:0001773)1.65734857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.05944273
2RIPK43.69634478
3FRK3.64444979
4MAP3K143.58307274
5TXK3.38924086
6IRAK43.08712411
7WNK32.69959567
8PNCK2.53325588
9NUAK12.45719439
10MAP3K42.35833991
11TNIK2.33226671
12MAP4K12.28332225
13IKBKE2.16134674
14TEC2.14995010
15KIT2.09881970
16TAOK32.02977643
17TYK22.02348279
18BLK1.95309298
19BMPR21.92308847
20BCR1.89356874
21JAK31.84427807
22GRK71.83398273
23MAP3K91.82730923
24NTRK21.81688944
25MAP3K131.77277453
26IKBKB1.71312429
27MAP4K21.68738852
28PIK3CA1.66085861
29IRAK31.61868791
30PINK11.61060303
31CASK1.58659391
32TRIM281.54519532
33SYK1.53193933
34PIK3CG1.50762737
35FES1.48292579
36JAK11.46516194
37CDK31.45636517
38SIK21.38483387
39TBK11.38272650
40DYRK21.34892260
41PAK31.32589682
42CHUK1.31075243
43YES11.29698279
44SIK31.27211979
45NEK61.23813336
46CSK1.23419366
47CDK191.21861433
48LCK1.21279932
49ITK1.21265282
50BTK1.19936615
51ZAP701.18568736
52ACVR1B1.17970170
53MST41.17203408
54ADRBK21.16197414
55DMPK1.14210135
56CAMKK21.12695697
57LYN1.11430656
58HCK1.10038419
59NLK1.05275889
60CSNK1G21.04479519
61CLK11.02021102
62PRKCQ0.97731031
63MAP2K70.96425076
64TGFBR20.96314814
65MAP2K40.96126686
66PIM10.94654252
67FGFR30.92795301
68MAP3K120.92270142
69MUSK0.91317240
70OXSR10.89091906
71SGK4940.87421808
72SGK2230.87421808
73MAPK130.87000364
74MINK10.86240582
75PRKCG0.86091709
76FGR0.85827429
77CSF1R0.85502846
78TNK20.84280533
79MKNK20.82318742
80EPHA30.80379341
81MAP3K60.79163093
82CSNK1G10.79007141
83GRK60.78232874
84CSNK1A1L0.77205178
85INSRR0.77107412
86IRAK10.76830391
87EIF2AK20.75932472
88EPHA40.75839452
89STK240.75110440
90CSNK1G30.73442248
91CAMK1G0.72883249
92BMPR1B0.72227590
93PRPF4B0.71792736
94CAMK40.71027083
95SGK20.70967874
96DYRK30.70769936
97MATK0.69120400
98STK100.69092908
99MARK20.66714481
100DYRK1A0.66011355
101UHMK10.65475907
102ZAK0.64533048
103KSR10.64146564
104MARK30.63810660
105MAPK70.63788386
106MKNK10.63738074
107TLK10.62157566
108BRD40.61230211
109NEK90.59899563
110STK110.59337872
111DAPK20.58057446
112PLK20.57814160
113MAPK150.57231650
114SRPK10.56967533
115TAOK10.56928989
116ADRBK10.56197180
117CCNB10.56087687
118ERBB30.55902371
119CAMK10.55860743
120PRKCZ0.54595902
121AKT30.53531517
122PKN10.53268923
123TIE10.53114497
124CAMK2A0.52934793
125STK40.52908524
126CDK50.52047034
127GRK10.51710858
128IRAK20.51500166
129SGK10.47749431
130TRPM70.47140525
131WNK40.46220956
132STK390.44915751
133STK160.44445964
134RAF10.44107705
135CSNK1D0.43706116
136SGK30.43118717
137MAPK120.42531552
138JAK20.40191783
139PRKACA0.39722138
140CAMKK10.38152455
141TYRO30.37912178
142FYN0.36532572
143ABL10.35480490
144PRKG10.35431292
145HIPK20.35201851
146PRKCE0.33824997
147IGF1R0.33213804
148ERBB20.32921582
149NTRK30.32689379
150RPS6KA50.32189504
151MAPKAPK50.30905407
152CDK90.30529380
153MAPKAPK20.29946382
154PDGFRB0.28752506
155VRK10.28692029
156PRKD20.28609550

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.82288280
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.50690552
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.32237393
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26675735
5Graft-versus-host disease_Homo sapiens_hsa053322.24609411
6Leishmaniasis_Homo sapiens_hsa051402.23145195
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11451608
8Allograft rejection_Homo sapiens_hsa053302.10084050
9Measles_Homo sapiens_hsa051622.05805200
10Osteoclast differentiation_Homo sapiens_hsa043802.04397061
11GABAergic synapse_Homo sapiens_hsa047271.98562763
12B cell receptor signaling pathway_Homo sapiens_hsa046621.87417518
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86904161
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80995381
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80696521
16Protein export_Homo sapiens_hsa030601.75346895
17Dorso-ventral axis formation_Homo sapiens_hsa043201.74403921
18T cell receptor signaling pathway_Homo sapiens_hsa046601.72930694
19Butanoate metabolism_Homo sapiens_hsa006501.72750130
20Hematopoietic cell lineage_Homo sapiens_hsa046401.67693987
21Dopaminergic synapse_Homo sapiens_hsa047281.67255762
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62335362
23Nitrogen metabolism_Homo sapiens_hsa009101.61165149
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.58285858
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54214400
26Herpes simplex infection_Homo sapiens_hsa051681.54153225
27Long-term depression_Homo sapiens_hsa047301.52121608
28Linoleic acid metabolism_Homo sapiens_hsa005911.52087539
29Autoimmune thyroid disease_Homo sapiens_hsa053201.50883245
30Staphylococcus aureus infection_Homo sapiens_hsa051501.46807242
31Cocaine addiction_Homo sapiens_hsa050301.46375136
32Chemokine signaling pathway_Homo sapiens_hsa040621.40192567
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40182696
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.38347308
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.35806953
36African trypanosomiasis_Homo sapiens_hsa051431.31487188
37Influenza A_Homo sapiens_hsa051641.31074380
38Nicotine addiction_Homo sapiens_hsa050331.27490373
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26500230
40Pertussis_Homo sapiens_hsa051331.25245772
41Antigen processing and presentation_Homo sapiens_hsa046121.25186635
42Toxoplasmosis_Homo sapiens_hsa051451.24244468
43TNF signaling pathway_Homo sapiens_hsa046681.23214708
44Tuberculosis_Homo sapiens_hsa051521.22287430
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22250494
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21906599
47Rheumatoid arthritis_Homo sapiens_hsa053231.21652846
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17177623
49Oxidative phosphorylation_Homo sapiens_hsa001901.13783815
50RNA degradation_Homo sapiens_hsa030181.13668865
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12832026
52Asthma_Homo sapiens_hsa053101.11289717
53Insulin secretion_Homo sapiens_hsa049111.08749531
54Malaria_Homo sapiens_hsa051441.03069786
55Platelet activation_Homo sapiens_hsa046111.01639223
56Hepatitis B_Homo sapiens_hsa051610.99860713
57Regulation of autophagy_Homo sapiens_hsa041400.99269450
58Ether lipid metabolism_Homo sapiens_hsa005650.99069896
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98397091
60Type I diabetes mellitus_Homo sapiens_hsa049400.96684670
61Salmonella infection_Homo sapiens_hsa051320.96438913
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94688334
63Cardiac muscle contraction_Homo sapiens_hsa042600.93473843
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93177390
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93003060
66Non-homologous end-joining_Homo sapiens_hsa034500.92776028
67Caffeine metabolism_Homo sapiens_hsa002320.91096208
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91060284
69Acute myeloid leukemia_Homo sapiens_hsa052210.90845804
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89328281
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.88266870
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86699010
73Collecting duct acid secretion_Homo sapiens_hsa049660.84409787
74Phototransduction_Homo sapiens_hsa047440.84023295
75Morphine addiction_Homo sapiens_hsa050320.83729361
76Parkinsons disease_Homo sapiens_hsa050120.83372168
77Propanoate metabolism_Homo sapiens_hsa006400.80605713
78Viral myocarditis_Homo sapiens_hsa054160.78968370
79Axon guidance_Homo sapiens_hsa043600.78077586
80Apoptosis_Homo sapiens_hsa042100.76616235
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76589898
82Serotonergic synapse_Homo sapiens_hsa047260.76229544
83Prolactin signaling pathway_Homo sapiens_hsa049170.76138830
84Hepatitis C_Homo sapiens_hsa051600.76123816
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75586110
86Renin secretion_Homo sapiens_hsa049240.74997609
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74797981
88ABC transporters_Homo sapiens_hsa020100.74643549
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.71221868
90Shigellosis_Homo sapiens_hsa051310.69844646
91Fanconi anemia pathway_Homo sapiens_hsa034600.68406406
92Taste transduction_Homo sapiens_hsa047420.66496890
93Gastric acid secretion_Homo sapiens_hsa049710.65770859
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64763906
95Circadian rhythm_Homo sapiens_hsa047100.64173520
96Peroxisome_Homo sapiens_hsa041460.63925784
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63748862
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63479270
99Phagosome_Homo sapiens_hsa041450.62595610
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62591370
101Legionellosis_Homo sapiens_hsa051340.61711150
102Tryptophan metabolism_Homo sapiens_hsa003800.60988886
103Pancreatic cancer_Homo sapiens_hsa052120.60124694
104MAPK signaling pathway_Homo sapiens_hsa040100.59675590
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59637190
106Cholinergic synapse_Homo sapiens_hsa047250.59455542
107Ovarian steroidogenesis_Homo sapiens_hsa049130.59294510
108Oxytocin signaling pathway_Homo sapiens_hsa049210.59096879
109Alzheimers disease_Homo sapiens_hsa050100.57559602
110Oocyte meiosis_Homo sapiens_hsa041140.57315289
111Epstein-Barr virus infection_Homo sapiens_hsa051690.56593226
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56404157
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56307541
114Salivary secretion_Homo sapiens_hsa049700.55486700
115Inositol phosphate metabolism_Homo sapiens_hsa005620.54955603
116cAMP signaling pathway_Homo sapiens_hsa040240.54707385
117Calcium signaling pathway_Homo sapiens_hsa040200.54575778
118Huntingtons disease_Homo sapiens_hsa050160.54429238
119Glutamatergic synapse_Homo sapiens_hsa047240.53945323
120Synaptic vesicle cycle_Homo sapiens_hsa047210.53222490
121Homologous recombination_Homo sapiens_hsa034400.52437612
122Chemical carcinogenesis_Homo sapiens_hsa052040.52402462
123Basal transcription factors_Homo sapiens_hsa030220.52115588
124Type II diabetes mellitus_Homo sapiens_hsa049300.52085583
125FoxO signaling pathway_Homo sapiens_hsa040680.52081100
126Olfactory transduction_Homo sapiens_hsa047400.50878703
127Hedgehog signaling pathway_Homo sapiens_hsa043400.50275842
128Long-term potentiation_Homo sapiens_hsa047200.50049345
129Other glycan degradation_Homo sapiens_hsa005110.50046207
130Prostate cancer_Homo sapiens_hsa052150.49986639
131Circadian entrainment_Homo sapiens_hsa047130.49768286
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49635403
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49394978
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49338809
135Amphetamine addiction_Homo sapiens_hsa050310.48772323
136Choline metabolism in cancer_Homo sapiens_hsa052310.48654852
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48276752
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46362063
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.46356791
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.45818969
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45694686
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.45030293
143Retinol metabolism_Homo sapiens_hsa008300.44981228
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44973740
145Chronic myeloid leukemia_Homo sapiens_hsa052200.44922070
146Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43516895
147Ras signaling pathway_Homo sapiens_hsa040140.43360140
148Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41514137
149Gap junction_Homo sapiens_hsa045400.40257277
150Primary bile acid biosynthesis_Homo sapiens_hsa001200.39109229
151Wnt signaling pathway_Homo sapiens_hsa043100.38695060
152Arachidonic acid metabolism_Homo sapiens_hsa005900.38345043
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37489228
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36537943
155Estrogen signaling pathway_Homo sapiens_hsa049150.34947662

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »