ARID3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glyoxylate metabolic process (GO:0046487)9.94072142
2regulation of fibrinolysis (GO:0051917)7.84296270
3L-phenylalanine catabolic process (GO:0006559)7.84277585
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.84277585
5negative regulation of fibrinolysis (GO:0051918)7.55490857
6epoxygenase P450 pathway (GO:0019373)7.55146447
7drug catabolic process (GO:0042737)7.52968928
8urea metabolic process (GO:0019627)7.46687216
9L-phenylalanine metabolic process (GO:0006558)7.21667292
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.21667292
11complement activation, alternative pathway (GO:0006957)7.01197338
12omega-hydroxylase P450 pathway (GO:0097267)6.91260758
13regulation of protein activation cascade (GO:2000257)6.85716407
14protein carboxylation (GO:0018214)6.78386795
15peptidyl-glutamic acid carboxylation (GO:0017187)6.78386795
16urea cycle (GO:0000050)6.76204228
17serine family amino acid catabolic process (GO:0009071)6.75885867
18exogenous drug catabolic process (GO:0042738)6.70808127
19nitrogen cycle metabolic process (GO:0071941)6.67820865
20oxidative demethylation (GO:0070989)6.64384127
21regulation of complement activation (GO:0030449)6.26427994
22ethanol oxidation (GO:0006069)6.19738859
23fibrinolysis (GO:0042730)6.15285703
24phenylpropanoid metabolic process (GO:0009698)6.09456681
25glycine metabolic process (GO:0006544)6.02152848
26nucleobase biosynthetic process (GO:0046112)5.90309092
27purine nucleobase biosynthetic process (GO:0009113)5.76820438
28blood coagulation, intrinsic pathway (GO:0007597)5.75299926
29mitotic metaphase plate congression (GO:0007080)5.73825037
30DNA deamination (GO:0045006)5.53186821
31vitamin transmembrane transport (GO:0035461)5.49695732
32bile acid biosynthetic process (GO:0006699)5.49563195
33ribosome assembly (GO:0042255)5.44481332
34drug metabolic process (GO:0017144)5.44263816
35negative regulation of cholesterol transport (GO:0032375)5.27962058
36negative regulation of sterol transport (GO:0032372)5.27962058
37cellular glucuronidation (GO:0052695)5.21928866
38serine family amino acid metabolic process (GO:0009069)5.18447297
39regulation of triglyceride catabolic process (GO:0010896)5.16053847
40ethanol metabolic process (GO:0006067)5.13104422
41regulation of plasminogen activation (GO:0010755)5.08205032
42aromatic amino acid family catabolic process (GO:0009074)5.06521301
43bile acid metabolic process (GO:0008206)4.95977161
44glucuronate metabolic process (GO:0019585)4.94156104
45uronic acid metabolic process (GO:0006063)4.94156104
46maturation of SSU-rRNA (GO:0030490)4.84103601
47bile acid and bile salt transport (GO:0015721)4.82862050
48proteasome assembly (GO:0043248)4.78679829
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.77940156
50serine family amino acid biosynthetic process (GO:0009070)4.61995302
51alkaloid metabolic process (GO:0009820)4.60805280
52hormone catabolic process (GO:0042447)4.52487799
53acylglycerol homeostasis (GO:0055090)4.50556808
54triglyceride homeostasis (GO:0070328)4.50556808
55protein activation cascade (GO:0072376)4.44222756
56midgut development (GO:0007494)4.41613598
57metaphase plate congression (GO:0051310)4.41087919
58negative regulation of blood coagulation (GO:0030195)4.35747522
59negative regulation of hemostasis (GO:1900047)4.35747522
60positive regulation of lipoprotein lipase activity (GO:0051006)4.33505244
61positive regulation of triglyceride lipase activity (GO:0061365)4.33505244
62DNA replication checkpoint (GO:0000076)4.31788705
63L-serine metabolic process (GO:0006563)4.28948990
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.28233597
65ribosome biogenesis (GO:0042254)4.27309236
66arginine metabolic process (GO:0006525)4.26765129
67regulation of spindle organization (GO:0090224)4.20898756
68alpha-amino acid catabolic process (GO:1901606)4.18010775
69phospholipid efflux (GO:0033700)4.16764525
70complement activation (GO:0006956)4.13214955
71transcription elongation from RNA polymerase III promoter (GO:0006385)4.12587514
72termination of RNA polymerase III transcription (GO:0006386)4.12587514
73cysteine metabolic process (GO:0006534)4.12144225
74tyrosine metabolic process (GO:0006570)4.11228065
75proline metabolic process (GO:0006560)4.11217247
76GMP metabolic process (GO:0046037)4.06848366
77kinetochore assembly (GO:0051382)4.02991176
78ribosomal large subunit biogenesis (GO:0042273)4.00279236
79negative regulation of wound healing (GO:0061045)3.99873535
80steroid catabolic process (GO:0006706)3.98488788
81complement activation, classical pathway (GO:0006958)3.96085119
82negative regulation of protein activation cascade (GO:2000258)3.94320516
83negative regulation of coagulation (GO:0050819)3.93610543
84polyketide metabolic process (GO:0030638)3.93059310
85doxorubicin metabolic process (GO:0044598)3.93059310
86daunorubicin metabolic process (GO:0044597)3.93059310
87transcription elongation from RNA polymerase I promoter (GO:0006362)3.92653528
88termination of RNA polymerase I transcription (GO:0006363)3.90245803
89amino-acid betaine metabolic process (GO:0006577)3.88646511
90regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.87885991
91imidazole-containing compound metabolic process (GO:0052803)3.87470546
92regulation of cholesterol esterification (GO:0010872)3.87411203
93ribonucleoprotein complex biogenesis (GO:0022613)3.86332392
94regulation of lipoprotein particle clearance (GO:0010984)3.85796983
95folic acid metabolic process (GO:0046655)3.84601479
96plasma lipoprotein particle remodeling (GO:0034369)3.84339356
97protein-lipid complex remodeling (GO:0034368)3.84339356
98macromolecular complex remodeling (GO:0034367)3.84339356
99sulfur amino acid catabolic process (GO:0000098)3.83523747
100acute-phase response (GO:0006953)3.82107347
101heme transport (GO:0015886)3.80966789
102rRNA modification (GO:0000154)3.78186001
103valine metabolic process (GO:0006573)3.78065181
104attachment of spindle microtubules to kinetochore (GO:0008608)3.76974837
105oocyte maturation (GO:0001556)3.74208482
106positive regulation of hemostasis (GO:1900048)3.72910036
107positive regulation of blood coagulation (GO:0030194)3.72910036
108aldehyde catabolic process (GO:0046185)3.72687146
109cellular amino acid catabolic process (GO:0009063)3.71249747
110negative regulation of lipase activity (GO:0060192)3.69553218
111regulation of humoral immune response (GO:0002920)3.69324684
112glutamate metabolic process (GO:0006536)3.67571742
113establishment of integrated proviral latency (GO:0075713)3.67571226
114negative regulation of complement activation (GO:0045916)3.64513224
115blastocyst development (GO:0001824)3.62988080
116pyrimidine nucleobase catabolic process (GO:0006208)3.60827483
117high-density lipoprotein particle remodeling (GO:0034375)3.60685303
118transcription from RNA polymerase I promoter (GO:0006360)3.60170775
119male meiosis I (GO:0007141)3.59451233
120microtubule depolymerization (GO:0007019)3.58035602
121cellular ketone body metabolic process (GO:0046950)3.57353310
122CENP-A containing nucleosome assembly (GO:0034080)3.57012685
123protein K6-linked ubiquitination (GO:0085020)3.54830405
124lung-associated mesenchyme development (GO:0060484)3.54349113
125meiosis I (GO:0007127)3.52153741
126regulation of centrosome cycle (GO:0046605)3.49780873
127cholesterol efflux (GO:0033344)3.46618587
128intestinal epithelial cell development (GO:0060576)3.46464149
129aminoglycoside antibiotic metabolic process (GO:0030647)3.45548923
130piRNA metabolic process (GO:0034587)3.44645994
131kinetochore organization (GO:0051383)3.44638895
132folic acid transport (GO:0015884)3.44265984
133drug transmembrane transport (GO:0006855)3.43283944
134transcription initiation from RNA polymerase I promoter (GO:0006361)3.43014941
135cytolysis (GO:0019835)3.42912958
136regulation of mitotic spindle organization (GO:0060236)3.42744960
137positive regulation of coagulation (GO:0050820)3.41931322
138establishment of chromosome localization (GO:0051303)3.38283324
139chromatin remodeling at centromere (GO:0031055)3.35662505
140rRNA processing (GO:0006364)3.33906830
141branched-chain amino acid metabolic process (GO:0009081)3.31761020
142mitotic sister chromatid segregation (GO:0000070)3.28996089
143oxaloacetate metabolic process (GO:0006107)3.27745000
144anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27424627
1457-methylguanosine mRNA capping (GO:0006370)3.27316258
146DNA strand elongation involved in DNA replication (GO:0006271)3.26161259
147S-adenosylmethionine metabolic process (GO:0046500)3.25708185
148rRNA metabolic process (GO:0016072)3.23519168
149very-low-density lipoprotein particle assembly (GO:0034379)3.22686674
150spindle checkpoint (GO:0031577)3.21852640
151regulation of exit from mitosis (GO:0007096)3.20684495
152negative regulation of fatty acid biosynthetic process (GO:0045717)3.20503008
153RNA capping (GO:0036260)3.16321678
1547-methylguanosine RNA capping (GO:0009452)3.16321678
155positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.16036788
156DNA replication-independent nucleosome organization (GO:0034724)3.15374532
157DNA replication-independent nucleosome assembly (GO:0006336)3.15374532
158mitotic spindle assembly checkpoint (GO:0007094)3.13453332
159negative regulation of chromosome segregation (GO:0051985)3.13438717
160negative regulation of mitotic sister chromatid separation (GO:2000816)3.12123188
161negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12123188
162negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12123188
163negative regulation of sister chromatid segregation (GO:0033046)3.12123188
164mitotic spindle checkpoint (GO:0071174)3.11788374
165regulation of chromosome segregation (GO:0051983)3.11343378
166histone exchange (GO:0043486)3.11056824
167positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10131611
168DNA replication initiation (GO:0006270)3.08610131
169DNA strand elongation (GO:0022616)3.08557254
170viral transcription (GO:0019083)3.07294018
171mitotic nuclear envelope disassembly (GO:0007077)3.07250643
172negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07186025
173spindle assembly checkpoint (GO:0071173)3.06981691
174otic vesicle formation (GO:0030916)3.06149391
175regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06035902
176translational initiation (GO:0006413)3.05366702
177regulation of nuclear cell cycle DNA replication (GO:0033262)3.02554742
178DNA integration (GO:0015074)3.02028194
179L-methionine salvage (GO:0071267)3.01230862
180L-methionine biosynthetic process (GO:0071265)3.01230862
181amino acid salvage (GO:0043102)3.01230862
182ribosomal small subunit biogenesis (GO:0042274)2.99124954
183formation of translation preinitiation complex (GO:0001731)2.99000631
184positive regulation of chromosome segregation (GO:0051984)2.97403674
185rRNA methylation (GO:0031167)2.97229901
186translational termination (GO:0006415)2.97042227
187spliceosomal snRNP assembly (GO:0000387)2.95934304
188protein complex localization (GO:0031503)2.95740211
189methionine metabolic process (GO:0006555)2.93631708
190somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91822369
191isotype switching (GO:0045190)2.91822369
192somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91822369
193transcription-coupled nucleotide-excision repair (GO:0006283)2.91419343
194methionine biosynthetic process (GO:0009086)2.91390983
195pyrimidine-containing compound transmembrane transport (GO:0072531)2.89205372
196protein localization to kinetochore (GO:0034501)2.88898253
197positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86248903
198cellular component biogenesis (GO:0044085)2.84432470
199DNA-templated transcription, elongation (GO:0006354)2.82609962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse6.74527798
2E2F7_22180533_ChIP-Seq_HELA_Human6.63553798
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.24899052
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.12850250
5PPARA_22158963_ChIP-Seq_LIVER_Mouse5.66782868
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.84233006
7MYC_18555785_ChIP-Seq_MESCs_Mouse4.47088057
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.32400152
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.12679648
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.00736741
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.00406380
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.76982082
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.75694743
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.71071302
15CREB1_15753290_ChIP-ChIP_HEK293T_Human3.59686002
16E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46852599
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35707839
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.33376796
19ETS1_20019798_ChIP-Seq_JURKAT_Human3.21780158
20* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.10321402
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.98056897
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97370713
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80964619
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79885614
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.79742608
26AR_21909140_ChIP-Seq_LNCAP_Human2.72577472
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.72383302
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66763611
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38801355
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36871611
31TP63_19390658_ChIP-ChIP_HaCaT_Human2.29133108
32XRN2_22483619_ChIP-Seq_HELA_Human2.18300309
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11057805
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08688773
35NANOG_18555785_ChIP-Seq_MESCs_Mouse2.08659704
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5155697
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97328465
38* HNF4A_19822575_ChIP-Seq_HepG2_Human1.94204887
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92938171
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.92208407
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84237083
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83032225
43VDR_23849224_ChIP-Seq_CD4+_Human1.81338868
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78873021
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.78225315
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.77725462
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77257663
48TTF2_22483619_ChIP-Seq_HELA_Human1.72186943
49TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70003752
50GABP_19822575_ChIP-Seq_HepG2_Human1.66323647
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57622519
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57354671
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55878629
54NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.55705310
55KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52436921
56FOXP3_21729870_ChIP-Seq_TREG_Human1.52176811
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52015840
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50242542
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49167459
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.47830265
61HTT_18923047_ChIP-ChIP_STHdh_Human1.46533023
62MYC_18940864_ChIP-ChIP_HL60_Human1.40576842
63RXRA_24833708_ChIP-Seq_LIVER_Mouse1.37656900
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37572840
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37166666
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36370508
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36328876
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.34403483
69DCP1A_22483619_ChIP-Seq_HELA_Human1.28906540
70NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.27663777
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25316294
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25316294
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25316294
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24381984
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22792185
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16983901
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16540493
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.16175723
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.16032606
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.15992785
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15971990
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15532126
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15392724
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15340761
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14423079
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13932708
87ZNF263_19887448_ChIP-Seq_K562_Human1.13525222
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11935062
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.11680499
90LXR_22292898_ChIP-Seq_THP-1_Human1.11594168
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11197846
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11101482
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10343401
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10093243
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.09987209
96CTCF_27219007_Chip-Seq_Bcells_Human1.08114358
97JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.08012518
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.07786978
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05911758
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05831233
101SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04942246
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04366282
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04002152
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03865240
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03017537
106ELK1_19687146_ChIP-ChIP_HELA_Human1.02346272
107SMC4_20622854_ChIP-Seq_HELA_Human1.01081900
108* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00489434
109SALL1_21062744_ChIP-ChIP_HESCs_Human1.00456215
110DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98783326
111PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95840752
112KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94855599
113SRF_21415370_ChIP-Seq_HL-1_Mouse0.94508829
114ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93041180
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92211042
116ESR2_21235772_ChIP-Seq_MCF-7_Human0.92175665
117ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91334564
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90491711
119POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89377869
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88689474
121NANOG_16153702_ChIP-ChIP_HESCs_Human0.87342724
122KAP1_27257070_Chip-Seq_ESCs_Mouse0.86320584
123POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.86247715
124TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84967948
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84866815
126ELF1_20517297_ChIP-Seq_JURKAT_Human0.84562751
127TET1_21451524_ChIP-Seq_MESCs_Mouse0.84380320
128IRF1_19129219_ChIP-ChIP_H3396_Human0.83427849
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82087823
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82003664
131KDM5A_27292631_Chip-Seq_BREAST_Human0.80954413
132CIITA_25753668_ChIP-Seq_RAJI_Human0.80570169
133FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.79958827
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77455818
135YY1_22570637_ChIP-Seq_MALME-3M_Human0.77135445
136SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76994073
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76358890
138FLI1_27457419_Chip-Seq_LIVER_Mouse0.74928056
139SOX17_20123909_ChIP-Seq_XEN_Mouse0.74196281
140SOX3_22085726_ChIP-Seq_NPCs_Mouse0.73829435
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.73695869
142* P68_20966046_ChIP-Seq_HELA_Human0.73478779
143TP63_17297297_ChIP-ChIP_HaCaT_Human0.72722514
144SOX2_18692474_ChIP-Seq_MESCs_Mouse0.72489020
145GATA4_25053715_ChIP-Seq_YYC3_Human0.72395924
146RARA_24833708_ChIP-Seq_LIVER_Mouse0.71694805
147NANOG_18692474_ChIP-Seq_MEFs_Mouse0.71620742
148SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.71580116
149SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.71525718
150CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.71417988
151SA1_27219007_Chip-Seq_Bcells_Human0.71018241
152CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.70551792
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70146907
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69137208
155SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68840090
156EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.68690924
157* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.68330326
158* E2F1_20622854_ChIP-Seq_HELA_Human0.68242304
159SOX2_21211035_ChIP-Seq_LN229_Human0.68023380
160RACK7_27058665_Chip-Seq_MCF-7_Human0.67012380
161* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.66401033
162GATA6_25053715_ChIP-Seq_YYC3_Human0.66158529
163SA1_27219007_Chip-Seq_ERYTHROID_Human0.65032082
164RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.64931698
165CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.63136168
166AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62978707
167MYC_19915707_ChIP-ChIP_AK7_Human0.61789308
168TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.61393522
169CREB1_26743006_Chip-Seq_LNCaP_Human0.61190417
170CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.60270728
171RBPJ_22232070_ChIP-Seq_NCS_Mouse0.59210966
172SPI1_26923725_Chip-Seq_HPCs_Mouse0.57475438
173WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.56315968
174CLOCK_20551151_ChIP-Seq_293T_Human0.55623194
175ISL1_27105846_Chip-Seq_CPCs_Mouse0.55601659
176RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55515296
177SOX11_22085726_ChIP-Seq_ESNs_Mouse0.54943481
178CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.54152543

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.84270434
2MP0005360_urolithiasis6.44020107
3MP0005085_abnormal_gallbladder_physiolo5.63040321
4MP0003693_abnormal_embryo_hatching5.15271950
5MP0005451_abnormal_body_composition5.11242661
6MP0005365_abnormal_bile_salt4.95802265
7MP0003718_maternal_effect4.57070452
8MP0009697_abnormal_copulation4.48816441
9MP0002138_abnormal_hepatobiliary_system4.22486441
10MP0003195_calcinosis4.21927176
11MP0003868_abnormal_feces_composition4.06214487
12MP0008877_abnormal_DNA_methylation3.94088462
13MP0003111_abnormal_nucleus_morphology3.75618661
14MP0010094_abnormal_chromosome_stability3.70621677
15MP0002876_abnormal_thyroid_physiology3.21707542
16MP0008260_abnormal_autophagy3.21359975
17MP0003252_abnormal_bile_duct3.04484753
18MP0004957_abnormal_blastocyst_morpholog3.02979562
19MP0003941_abnormal_skin_development3.01109675
20MP0006292_abnormal_olfactory_placode2.82059517
21MP0003123_paternal_imprinting2.78700734
22MP0003077_abnormal_cell_cycle2.75737582
23MP0001666_abnormal_nutrient_absorption2.75381728
24MP0010030_abnormal_orbit_morphology2.72566900
25MP0008058_abnormal_DNA_repair2.68925868
26MP0010329_abnormal_lipoprotein_level2.30979788
27MP0003011_delayed_dark_adaptation2.21702343
28MP0008932_abnormal_embryonic_tissue2.19900703
29MP0003806_abnormal_nucleotide_metabolis2.18924752
30MP0005332_abnormal_amino_acid2.08071749
31MP0003315_abnormal_perineum_morphology1.88540097
32MP0003786_premature_aging1.87347335
33MP0009379_abnormal_foot_pigmentation1.86017261
34MP0008057_abnormal_DNA_replication1.82997757
35MP0001764_abnormal_homeostasis1.81619110
36MP0005187_abnormal_penis_morphology1.80176635
37MP0001730_embryonic_growth_arrest1.70161233
38MP0009053_abnormal_anal_canal1.63815594
39MP0005395_other_phenotype1.61176940
40MP0003890_abnormal_embryonic-extraembry1.60503443
41MP0002210_abnormal_sex_determination1.59545949
42MP0000609_abnormal_liver_physiology1.56069931
43MP0003646_muscle_fatigue1.53722360
44MP0003221_abnormal_cardiomyocyte_apopto1.53692910
45MP0003938_abnormal_ear_development1.48768083
46MP0001661_extended_life_span1.48455124
47MP0001672_abnormal_embryogenesis/_devel1.43356536
48MP0005380_embryogenesis_phenotype1.43356536
49MP0000653_abnormal_sex_gland1.38887014
50MP0002118_abnormal_lipid_homeostasis1.36234593
51MP0001145_abnormal_male_reproductive1.36061182
52MP0005248_abnormal_Harderian_gland1.33833224
53MP0008789_abnormal_olfactory_epithelium1.33696475
54MP0001915_intracranial_hemorrhage1.30664399
55MP0004019_abnormal_vitamin_homeostasis1.26848456
56MP0000350_abnormal_cell_proliferation1.25207666
57MP0003191_abnormal_cellular_cholesterol1.24952110
58MP0001929_abnormal_gametogenesis1.24399699
59MP0006072_abnormal_retinal_apoptosis1.23348964
60MP0002653_abnormal_ependyma_morphology1.23316047
61MP0002085_abnormal_embryonic_tissue1.20619250
62MP0003119_abnormal_digestive_system1.20580274
63MP0005389_reproductive_system_phenotype1.17523828
64MP0005394_taste/olfaction_phenotype1.17053244
65MP0005499_abnormal_olfactory_system1.17053244
66MP0005408_hypopigmentation1.16930924
67MP0000566_synostosis1.16361128
68MP0003136_yellow_coat_color1.14440490
69MP0003937_abnormal_limbs/digits/tail_de1.12797405
70MP0002160_abnormal_reproductive_system1.12305184
71MP0001188_hyperpigmentation1.12183649
72MP0002697_abnormal_eye_size1.11958927
73MP0001293_anophthalmia1.11739512
74MP0003121_genomic_imprinting1.10825080
75MP0003699_abnormal_female_reproductive1.06563815
76MP0001119_abnormal_female_reproductive1.04203624
77MP0001697_abnormal_embryo_size1.03227741
78MP0002080_prenatal_lethality1.03076673
79MP0008007_abnormal_cellular_replicative1.01702521
80MP0003878_abnormal_ear_physiology1.01656339
81MP0005377_hearing/vestibular/ear_phenot1.01656339
82MP0003984_embryonic_growth_retardation1.01547746
83MP0000598_abnormal_liver_morphology1.01251472
84MP0009672_abnormal_birth_weight1.01034491
85MP0005551_abnormal_eye_electrophysiolog0.99714207
86MP0003879_abnormal_hair_cell0.99468454
87MP0002084_abnormal_developmental_patter0.98935383
88MP0002088_abnormal_embryonic_growth/wei0.98550103
89MP0003567_abnormal_fetal_cardiomyocyte0.96754480
90MP0010234_abnormal_vibrissa_follicle0.92296563
91MP0002161_abnormal_fertility/fecundity0.92115659
92MP0010368_abnormal_lymphatic_system0.91193805
93MP0003705_abnormal_hypodermis_morpholog0.90110380
94MP0004270_analgesia0.89864928
95MP0002249_abnormal_larynx_morphology0.89226767
96MP0001919_abnormal_reproductive_system0.88120934
97MP0000747_muscle_weakness0.87713426
98MP0003787_abnormal_imprinting0.87144572
99MP0002102_abnormal_ear_morphology0.85909672
100MP0002234_abnormal_pharynx_morphology0.85703397
101MP0002111_abnormal_tail_morphology0.85617546
102MP0002282_abnormal_trachea_morphology0.85536851
103MP0003698_abnormal_male_reproductive0.84804927
104MP0002089_abnormal_postnatal_growth/wei0.83733794
105MP0005319_abnormal_enzyme/_coenzyme0.82872480
106MP0003936_abnormal_reproductive_system0.81819371
107MP0001529_abnormal_vocalization0.80544340
108MP0008875_abnormal_xenobiotic_pharmacok0.78585047
109MP0002092_abnormal_eye_morphology0.77974660
110MP0000428_abnormal_craniofacial_morphol0.77544381
111MP0005584_abnormal_enzyme/coenzyme_acti0.76826555
112MP0003935_abnormal_craniofacial_develop0.76463027
113MP0000490_abnormal_crypts_of0.75591593
114MP0002233_abnormal_nose_morphology0.74725764
115MP0001346_abnormal_lacrimal_gland0.74427755
116MP0002277_abnormal_respiratory_mucosa0.74006532
117MP0000579_abnormal_nail_morphology0.73904026
118MP0002938_white_spotting0.73249664
119MP0005391_vision/eye_phenotype0.72757954
120MP0000751_myopathy0.70617408
121MP0009643_abnormal_urine_homeostasis0.69947483
122MP0004133_heterotaxia0.69891146
123MP0004885_abnormal_endolymph0.69868101
124MP0002132_abnormal_respiratory_system0.69556526
125MP0004197_abnormal_fetal_growth/weight/0.68194052
126MP0005636_abnormal_mineral_homeostasis0.67897906
127MP0000432_abnormal_head_morphology0.67439710
128MP0001905_abnormal_dopamine_level0.67270904
129MP0003950_abnormal_plasma_membrane0.67245056
130MP0009840_abnormal_foam_cell0.65979361
131MP0003122_maternal_imprinting0.65700894
132MP0000313_abnormal_cell_death0.65575268
133MP0000750_abnormal_muscle_regeneration0.65491983
134MP0002752_abnormal_somatic_nervous0.63921719
135MP0000627_abnormal_mammary_gland0.63173360
136MP0005058_abnormal_lysosome_morphology0.63067645
137MP0009642_abnormal_blood_homeostasis0.62307965
138MP0003861_abnormal_nervous_system0.61666400
139MP0009333_abnormal_splenocyte_physiolog0.61090526
140MP0003186_abnormal_redox_activity0.59594854
141MP0001849_ear_inflammation0.59414025
142MP0000613_abnormal_salivary_gland0.59056008
143MP0003638_abnormal_response/metabolism_0.56546620
144MP0003959_abnormal_lean_body0.54892893
145MP0000604_amyloidosis0.54478566
146MP0002822_catalepsy0.53843512
147MP0005197_abnormal_uvea_morphology0.52908395
148MP0004782_abnormal_surfactant_physiolog0.51166447
149MP0005376_homeostasis/metabolism_phenot0.51065130
150MP0000537_abnormal_urethra_morphology0.50512646
151MP0002168_other_aberrant_phenotype0.46357445
152MP0005334_abnormal_fat_pad0.43319773
153MP0003656_abnormal_erythrocyte_physiolo0.39732128
154MP0000427_abnormal_hair_cycle0.36002307
155MP0001286_abnormal_eye_development0.35261138
156MP0008874_decreased_physiological_sensi0.35044856
157MP0000647_abnormal_sebaceous_gland0.33547477
158MP0003115_abnormal_respiratory_system0.32579346
159MP0001340_abnormal_eyelid_morphology0.32302673
160MP0002098_abnormal_vibrissa_morphology0.31699883
161MP0002971_abnormal_brown_adipose0.31399020
162MP0005535_abnormal_body_temperature0.30663458
163MP0009703_decreased_birth_body0.30559050
164MP0002078_abnormal_glucose_homeostasis0.30341774
165MP0003755_abnormal_palate_morphology0.30092876
166MP0009763_increased_sensitivity_to0.29038780
167MP0005193_abnormal_anterior_eye0.28793596
168MP0003329_amyloid_beta_deposits0.28350651
169MP0001881_abnormal_mammary_gland0.28211048
170MP0002090_abnormal_vision0.27598780
171MP0001944_abnormal_pancreas_morphology0.24761554
172MP0004272_abnormal_basement_membrane0.24194529

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)8.17848561
2Hypobetalipoproteinemia (HP:0003563)7.59075110
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.47421329
4Complement deficiency (HP:0004431)7.07535967
5Abnormality of pyrimidine metabolism (HP:0004353)6.35322849
6Breast hypoplasia (HP:0003187)6.08158234
7Abnormality of complement system (HP:0005339)5.76449170
8Joint hemorrhage (HP:0005261)5.42841559
9Birth length less than 3rd percentile (HP:0003561)4.94233252
10Intrahepatic cholestasis (HP:0001406)4.88174254
11Hyperlipoproteinemia (HP:0010980)4.83104048
12Conjugated hyperbilirubinemia (HP:0002908)4.55532369
13Systemic lupus erythematosus (HP:0002725)4.43343036
14Hypolipoproteinemia (HP:0010981)4.19213033
15Abnormal gallbladder physiology (HP:0012438)4.01208771
16Cholecystitis (HP:0001082)4.01208771
17Glomerulonephritis (HP:0000099)3.88975504
18Xanthomatosis (HP:0000991)3.85891150
19Cerebral hypomyelination (HP:0006808)3.84253877
20Abnormality of the common coagulation pathway (HP:0010990)3.75722632
21Abnormality of abdominal situs (HP:0011620)3.75616186
22Abdominal situs inversus (HP:0003363)3.75616186
23Concave nail (HP:0001598)3.70739367
24Abnormality of the intrinsic pathway (HP:0010989)3.63148263
25Carpal bone hypoplasia (HP:0001498)3.62326920
26Impulsivity (HP:0100710)3.53801657
27Rough bone trabeculation (HP:0100670)3.53080597
28Hyperglycinemia (HP:0002154)3.47077616
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.41806407
30Abnormality of alanine metabolism (HP:0010916)3.41806407
31Hyperalaninemia (HP:0003348)3.41806407
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.35535967
33Abnormality of methionine metabolism (HP:0010901)3.35005293
34Ventricular fibrillation (HP:0001663)3.31654649
35Megaloblastic anemia (HP:0001889)3.29559113
36Osteomalacia (HP:0002749)3.28894105
37Macrocytic anemia (HP:0001972)3.28295190
38Abnormality of glutamine family amino acid metabolism (HP:0010902)3.25486461
39Delayed CNS myelination (HP:0002188)3.21573160
40Increased corneal curvature (HP:0100692)3.20123633
41Keratoconus (HP:0000563)3.20123633
42Hyperglycinuria (HP:0003108)3.16071479
43Absent radius (HP:0003974)3.10211818
44Reduced antithrombin III activity (HP:0001976)3.09471380
45Adrenal hypoplasia (HP:0000835)3.08112772
46Hyperammonemia (HP:0001987)3.05810837
47Spontaneous abortion (HP:0005268)3.05119180
48Reticulocytopenia (HP:0001896)3.01021472
49Abnormality of glycolysis (HP:0004366)2.97551915
50Increased serum pyruvate (HP:0003542)2.97551915
51Recurrent gram-negative bacterial infections (HP:0005420)2.89189611
52Aplasia involving forearm bones (HP:0009822)2.88813241
53Absent forearm bone (HP:0003953)2.88813241
54Secondary amenorrhea (HP:0000869)2.87004657
55Abnormality of nucleobase metabolism (HP:0010932)2.86559445
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.86374386
57Hypoalphalipoproteinemia (HP:0003233)2.85372850
58CNS hypomyelination (HP:0003429)2.84197639
59Patellar aplasia (HP:0006443)2.80316550
60Sparse lateral eyebrow (HP:0005338)2.78034279
61Supernumerary spleens (HP:0009799)2.77749163
62Aplasia/Hypoplasia of the patella (HP:0006498)2.72546085
63Stenosis of the external auditory canal (HP:0000402)2.71223040
64Premature ovarian failure (HP:0008209)2.70483097
65Arthropathy (HP:0003040)2.69901997
66Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.68834298
67Nephritis (HP:0000123)2.63965850
68Abnormality of serum amino acid levels (HP:0003112)2.62738491
69Aplasia/Hypoplasia of the breasts (HP:0010311)2.59612316
70Gout (HP:0001997)2.59093584
71Abnormal trabecular bone morphology (HP:0100671)2.57554371
72Microvesicular hepatic steatosis (HP:0001414)2.55445930
73Abnormal tarsal ossification (HP:0008369)2.53394307
74Neonatal hypoglycemia (HP:0001998)2.52364745
75Brittle hair (HP:0002299)2.51698382
76Hemorrhage of the eye (HP:0011885)2.50091287
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49268502
78Abnormality of serine family amino acid metabolism (HP:0010894)2.48946044
79Abnormality of glycine metabolism (HP:0010895)2.48946044
80Cholelithiasis (HP:0001081)2.47691469
81Aplasia/Hypoplasia involving the musculature (HP:0001460)2.45211988
82Anal stenosis (HP:0002025)2.43585493
83Menorrhagia (HP:0000132)2.43065726
84Chromsome breakage (HP:0040012)2.41014852
85Fat malabsorption (HP:0002630)2.40841588
86Abnormality of secondary sexual hair (HP:0009888)2.40175086
87Abnormality of the axillary hair (HP:0100134)2.40175086
88Congenital, generalized hypertrichosis (HP:0004540)2.39784410
89Horseshoe kidney (HP:0000085)2.38315868
90Hypercholesterolemia (HP:0003124)2.36173974
91Septo-optic dysplasia (HP:0100842)2.34788395
92Breast aplasia (HP:0100783)2.33264958
93Abnormality of the preputium (HP:0100587)2.32554858
94Rickets (HP:0002748)2.32491068
95Abnormality of sulfur amino acid metabolism (HP:0004339)2.28320483
96Meckel diverticulum (HP:0002245)2.26112437
97Generalized aminoaciduria (HP:0002909)2.25863362
98Ureteral duplication (HP:0000073)2.23767218
99Abnormal gallbladder morphology (HP:0012437)2.23521393
100Fair hair (HP:0002286)2.22522721
101Prolonged neonatal jaundice (HP:0006579)2.21487258
102Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.21165926
103Glucose intolerance (HP:0000833)2.18110693
104Mutism (HP:0002300)2.17020192
105Elevated alkaline phosphatase (HP:0003155)2.15299890
106Bile duct proliferation (HP:0001408)2.15034979
107Abnormal biliary tract physiology (HP:0012439)2.15034979
108Muscle fiber splitting (HP:0003555)2.13832323
109Abnormality of carpal bone ossification (HP:0006257)2.13481566
110Absent thumb (HP:0009777)2.12443314
111Hyperbilirubinemia (HP:0002904)2.12350011
112Congenital stationary night blindness (HP:0007642)2.11577421
113Oligodactyly (HP:0012165)2.11130715
114Mitral stenosis (HP:0001718)2.09845462
115Male infertility (HP:0003251)2.09451705
116Rhabdomyosarcoma (HP:0002859)2.08258807
117Delusions (HP:0000746)2.06987051
118Aplasia/Hypoplasia of the uvula (HP:0010293)2.05190797
119Progressive muscle weakness (HP:0003323)2.03892312
120Abnormality of the labia minora (HP:0012880)2.03827400
121Abnormal spermatogenesis (HP:0008669)2.03654985
122Abnormality of the Achilles tendon (HP:0005109)2.02543994
123Abnormality of chromosome stability (HP:0003220)2.01234771
124Deep venous thrombosis (HP:0002625)10.7537058
125Abnormality of monocarboxylic acid metabolism (HP:0010996)10.2933636
126Steatorrhea (HP:0002570)1.99977368
127Abnormality of the phalanges of the 2nd finger (HP:0009541)1.99253078
128Abnormality of the ileum (HP:0001549)1.99225862
129Oral leukoplakia (HP:0002745)1.98559596
130Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98062540
131Epidermoid cyst (HP:0200040)1.97210219
132Esophageal atresia (HP:0002032)1.96851981
133Metabolic acidosis (HP:0001942)1.96704791
134Abnormality of alkaline phosphatase activity (HP:0004379)1.95751277
135Pili torti (HP:0003777)1.94823229
136Abnormality of the umbilical cord (HP:0010881)1.94704833
137Abnormal enzyme/coenzyme activity (HP:0012379)1.94676076
138Hepatocellular carcinoma (HP:0001402)1.94554144
139Bifid scrotum (HP:0000048)1.93602492
140Facial cleft (HP:0002006)1.93462073
141Areflexia of lower limbs (HP:0002522)1.92573700
142Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.91841888
143Pallor (HP:0000980)1.90687079
144Oligodactyly (hands) (HP:0001180)1.90384431
145Ependymoma (HP:0002888)1.89236475
146Vascular calcification (HP:0004934)1.88829683
147Bone marrow hypocellularity (HP:0005528)1.88647367
148Hypoplasia of the radius (HP:0002984)1.87815031
149Pancreatic fibrosis (HP:0100732)1.87473236
150Triphalangeal thumb (HP:0001199)1.86568945
151Tracheoesophageal fistula (HP:0002575)1.86301662
152Bony spicule pigmentary retinopathy (HP:0007737)1.86218128
153Shoulder girdle muscle weakness (HP:0003547)1.85987072
154Duodenal stenosis (HP:0100867)1.84808750
155Small intestinal stenosis (HP:0012848)1.84808750
156Sparse eyelashes (HP:0000653)1.84392656
157Aplasia/hypoplasia of the uterus (HP:0008684)1.82719071
158Abnormality of the gallbladder (HP:0005264)1.82250802
159Absent hand (HP:0004050)1.81839202
160Pelvic girdle muscle weakness (HP:0003749)1.81421685
161Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81074329
162Irritability (HP:0000737)1.80767824
163Entropion (HP:0000621)1.79651061
164Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79382026
165Submucous cleft hard palate (HP:0000176)1.76366031
166Hyperphosphaturia (HP:0003109)1.75920500
167Pulmonary embolism (HP:0002204)1.74088012
168Proximal tubulopathy (HP:0000114)1.72147412
169Atrioventricular block (HP:0001678)1.70838252
170Abnormality of the lower motor neuron (HP:0002366)1.68489116
171Abnormal ossification of hand bones (HP:0005921)1.66423018
172Decreased subcutaneous fat (HP:0001002)1.65748086
173Cardiovascular calcification (HP:0011915)1.65391857
174Gingival bleeding (HP:0000225)1.63693889
175Abnormal hand bone ossification (HP:0010660)1.60508131
176Abnormal foot bone ossification (HP:0010675)1.59961616
177Purpura (HP:0000979)1.57000385
178Ketosis (HP:0001946)1.56938413
179Flat acetabular roof (HP:0003180)1.54902028
180Partial duplication of thumb phalanx (HP:0009944)1.53978468
181Morphological abnormality of the pyramidal tract (HP:0002062)1.53033364
182Hypochromic microcytic anemia (HP:0004840)1.52251653
183Reticulocytosis (HP:0001923)1.51481081
184Abnormal urine phosphate concentration (HP:0012599)1.50130849
185Paraparesis (HP:0002385)1.49623017
186Duplication of thumb phalanx (HP:0009942)1.48515560
187Metaphyseal cupping (HP:0003021)1.45136755
188Thrombophlebitis (HP:0004418)1.42375067
189Abnormal cartilage morphology (HP:0002763)1.42104020
190Protuberant abdomen (HP:0001538)1.38258250
191Cerebral edema (HP:0002181)1.36313337
192Alkalosis (HP:0001948)1.36245857
193Abnormality of reticulocytes (HP:0004312)1.36043104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.97228482
2NEK24.38464078
3EPHA44.00416185
4AKT33.68293095
5PLK43.17998145
6MUSK2.88045708
7TTK2.77057125
8WEE12.69361970
9MET2.66576697
10CDC72.62588937
11TSSK62.55812181
12LATS22.33335037
13RIPK12.23512708
14CASK2.21188740
15EPHB22.20722380
16STK38L2.19540696
17IRAK32.14464163
18FGFR41.96326363
19PKN21.95859153
20EIF2AK11.95729032
21BMX1.92448797
22BRD41.88731910
23PLK11.85260700
24SRPK11.79849698
25PDK31.78725211
26PDK41.78725211
27MST1R1.70886357
28MKNK11.63332893
29STK161.62774086
30CDK191.62582920
31FGR1.59985530
32NEK11.57392805
33PLK21.55544287
34MKNK21.54961483
35CHEK21.53378202
36BCKDK1.53377228
37CAMK1G1.51850758
38CDK121.48787091
39MAP3K101.42112605
40EIF2AK31.37390184
41PLK31.37295483
42EIF2AK21.32108772
43MAP2K41.31787723
44BRAF1.28251616
45AURKB1.25960177
46STK31.25476581
47PBK1.24394037
48EPHA21.23136313
49SMG11.20749920
50ALK1.20572959
51MAP3K91.20380844
52SIK11.16133051
53PASK1.15922556
54CSNK1G11.14621145
55CDK61.14251167
56RET1.12639494
57VRK11.12526960
58ICK1.07926399
59PAK41.07543493
60AURKA1.06423843
61PTK61.06309274
62BRSK11.06299608
63BRSK21.04798372
64IRAK21.04574611
65TYRO31.03706052
66TNIK1.01224552
67PINK11.00908007
68PDK21.00224113
69CCNB10.99580906
70CSNK1G30.99275705
71WNK30.98087093
72MAP3K80.92769917
73STK240.91991670
74MARK10.90954941
75CDK30.90639413
76PTK20.89952673
77FER0.88755838
78PRKCG0.86921997
79CSNK1A1L0.84146965
80CDK40.78846448
81PAK10.77502546
82ERN10.77073142
83PNCK0.75783815
84NEK90.75743456
85RPS6KA40.75068743
86CDK11A0.74841296
87RPS6KB20.73682427
88PRKACG0.72481900
89NME10.72324560
90CAMK1D0.72322040
91CHEK10.71351642
92MTOR0.71345196
93CSNK1E0.71022787
94CAMKK10.70305147
95MAP3K30.70062822
96JAK20.68723176
97PAK60.62392922
98CDK180.61675166
99CDK70.60485898
100STK100.59965343
101CDK150.58303060
102IRAK10.57473599
103NTRK10.57233194
104CDK140.57178131
105CDK20.56863326
106CSNK2A20.56771074
107FGFR20.56434890
108NME20.56341582
109CSNK1G20.56004074
110GRK10.55972671
111LRRK20.55757343
112CSNK2A10.54884745
113MAPK130.54848798
114DYRK30.54760595
115TGFBR10.54736103
116TAOK20.54190166
117PDPK10.52358716
118PDGFRA0.52074651
119PAK20.51848499
120LATS10.50957188
121DYRK20.50789462
122AKT20.50294699
123CSF1R0.48458448
124PRKD30.48249111
125CDK10.47959284
126KSR10.47428127
127SIK30.46684826
128ATR0.44415699
129PIK3CG0.42477755
130MAP2K20.42332804
131IGF1R0.38822360
132STK380.38195756
133PRKCI0.37980127
134ERBB20.37306055
135MAP3K60.35876504
136MAP3K70.35584237
137PRPF4B0.35345427
138EEF2K0.35335880
139NTRK30.34778409
140TESK10.32844505
141FLT30.32730758
142ATM0.32378632
143MAPK100.31196265
144DYRK1A0.31177837
145VRK20.30962899
146MAPK90.30873854
147SRC0.30723283
148TRIB30.30098850
149DYRK1B0.28842378
150MINK10.28283206
151PRKAA10.25263634
152MAP3K40.25190758
153OXSR10.21721660
154STK40.21618821
155RPS6KA50.21587507
156GSK3B0.20144989
157STK110.19046774
158FGFR10.18427816
159NTRK20.17963745
160ARAF0.16656049
161MAPK140.15874793
162MAP3K120.15815380

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.48774549
2RNA polymerase_Homo sapiens_hsa030204.39266921
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.93617196
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.88640080
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.75876249
6Complement and coagulation cascades_Homo sapiens_hsa046103.54323713
7Mismatch repair_Homo sapiens_hsa034303.30532348
8Proteasome_Homo sapiens_hsa030503.25544916
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.11387272
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.11214551
11Ribosome_Homo sapiens_hsa030103.09496365
12Homologous recombination_Homo sapiens_hsa034403.07532019
13Arginine biosynthesis_Homo sapiens_hsa002202.99325406
14DNA replication_Homo sapiens_hsa030302.91221095
15Folate biosynthesis_Homo sapiens_hsa007902.90192630
16Base excision repair_Homo sapiens_hsa034102.88516804
17RNA transport_Homo sapiens_hsa030132.85596229
18Phenylalanine metabolism_Homo sapiens_hsa003602.74556936
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.66154212
20Chemical carcinogenesis_Homo sapiens_hsa052042.61196658
21Pyrimidine metabolism_Homo sapiens_hsa002402.54789739
22Steroid hormone biosynthesis_Homo sapiens_hsa001402.53147667
23Pentose and glucuronate interconversions_Homo sapiens_hsa000402.45860653
24Nucleotide excision repair_Homo sapiens_hsa034202.34883254
25Fatty acid degradation_Homo sapiens_hsa000712.23140545
26Cell cycle_Homo sapiens_hsa041102.22680927
27Basal transcription factors_Homo sapiens_hsa030222.22548856
28Tyrosine metabolism_Homo sapiens_hsa003502.15458985
29Spliceosome_Homo sapiens_hsa030402.14072831
30Fanconi anemia pathway_Homo sapiens_hsa034602.01093012
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.97928680
32Bile secretion_Homo sapiens_hsa049761.89610941
33Purine metabolism_Homo sapiens_hsa002301.76599550
34Oocyte meiosis_Homo sapiens_hsa041141.71059837
35One carbon pool by folate_Homo sapiens_hsa006701.70942686
36Histidine metabolism_Homo sapiens_hsa003401.68372056
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.61418155
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.59443652
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58299170
40Regulation of autophagy_Homo sapiens_hsa041401.56211995
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56144953
42Pyruvate metabolism_Homo sapiens_hsa006201.55682099
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54264596
44Fructose and mannose metabolism_Homo sapiens_hsa000511.50730416
45Vitamin digestion and absorption_Homo sapiens_hsa049771.49626190
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49531385
47p53 signaling pathway_Homo sapiens_hsa041151.48740513
48Peroxisome_Homo sapiens_hsa041461.43717368
49RNA degradation_Homo sapiens_hsa030181.42611606
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.41896985
51Tryptophan metabolism_Homo sapiens_hsa003801.39693549
52Selenocompound metabolism_Homo sapiens_hsa004501.37602220
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.36021291
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30188509
55Ether lipid metabolism_Homo sapiens_hsa005651.29836728
56Starch and sucrose metabolism_Homo sapiens_hsa005001.28701293
57beta-Alanine metabolism_Homo sapiens_hsa004101.25920871
58Pentose phosphate pathway_Homo sapiens_hsa000301.22954390
59PPAR signaling pathway_Homo sapiens_hsa033201.16199983
60mRNA surveillance pathway_Homo sapiens_hsa030151.15663884
61Biosynthesis of amino acids_Homo sapiens_hsa012301.12551445
62Prion diseases_Homo sapiens_hsa050201.12435169
63Glycerophospholipid metabolism_Homo sapiens_hsa005641.06174956
64Propanoate metabolism_Homo sapiens_hsa006401.03868581
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02729056
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00211655
67Epstein-Barr virus infection_Homo sapiens_hsa051691.00139541
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98529103
69Non-homologous end-joining_Homo sapiens_hsa034500.97260239
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83819759
71Sulfur metabolism_Homo sapiens_hsa009200.82927477
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80509476
73Lysine degradation_Homo sapiens_hsa003100.77989888
74Fatty acid metabolism_Homo sapiens_hsa012120.77171014
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74027266
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73858087
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73765914
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.67420728
79Steroid biosynthesis_Homo sapiens_hsa001000.60574997
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.59926090
81ABC transporters_Homo sapiens_hsa020100.58930530
82Nicotine addiction_Homo sapiens_hsa050330.57489721
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56222350
84Circadian rhythm_Homo sapiens_hsa047100.55487916
85Fat digestion and absorption_Homo sapiens_hsa049750.54318933
86Sulfur relay system_Homo sapiens_hsa041220.54141940
87Linoleic acid metabolism_Homo sapiens_hsa005910.52903087
88Retinol metabolism_Homo sapiens_hsa008300.52829385
89Phototransduction_Homo sapiens_hsa047440.50730666
90Staphylococcus aureus infection_Homo sapiens_hsa051500.50083087
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49862893
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49839202
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.49240044
94Fatty acid elongation_Homo sapiens_hsa000620.48937462
95Galactose metabolism_Homo sapiens_hsa000520.44531595
96Metabolic pathways_Homo sapiens_hsa011000.44520587
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43772063
98HIF-1 signaling pathway_Homo sapiens_hsa040660.43740914
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41000811
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40599006
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38056629
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36376382
103Carbon metabolism_Homo sapiens_hsa012000.35993290
104Melanoma_Homo sapiens_hsa052180.35829353
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.35772857
106Ovarian steroidogenesis_Homo sapiens_hsa049130.35519647
107Glutathione metabolism_Homo sapiens_hsa004800.35489611
108Hedgehog signaling pathway_Homo sapiens_hsa043400.35436905
109Arginine and proline metabolism_Homo sapiens_hsa003300.34605168
110Glucagon signaling pathway_Homo sapiens_hsa049220.33922928
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33390192
112Synaptic vesicle cycle_Homo sapiens_hsa047210.32958318
113Sphingolipid metabolism_Homo sapiens_hsa006000.32454287
114HTLV-I infection_Homo sapiens_hsa051660.27755164
115Glycerolipid metabolism_Homo sapiens_hsa005610.26269692
116mTOR signaling pathway_Homo sapiens_hsa041500.24978999
117Tight junction_Homo sapiens_hsa045300.24658619
118Protein export_Homo sapiens_hsa030600.21570241
119Inositol phosphate metabolism_Homo sapiens_hsa005620.20206512
120Renal cell carcinoma_Homo sapiens_hsa052110.19367635
121Insulin resistance_Homo sapiens_hsa049310.17878204
122Hippo signaling pathway_Homo sapiens_hsa043900.17365700
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14924131
124Small cell lung cancer_Homo sapiens_hsa052220.14465394
125Butanoate metabolism_Homo sapiens_hsa006500.12902206
126Huntingtons disease_Homo sapiens_hsa050160.11172569
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10833886
128AMPK signaling pathway_Homo sapiens_hsa041520.09550019
129MicroRNAs in cancer_Homo sapiens_hsa052060.08683778
130ErbB signaling pathway_Homo sapiens_hsa040120.08115432
131Other glycan degradation_Homo sapiens_hsa005110.07147985
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.06095893
133Basal cell carcinoma_Homo sapiens_hsa052170.05006791
134Pertussis_Homo sapiens_hsa051330.04166088
135Nitrogen metabolism_Homo sapiens_hsa009100.03647128
1362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.03616590
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.02804675
138Caffeine metabolism_Homo sapiens_hsa002320.01534062
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.00803643
140Arachidonic acid metabolism_Homo sapiens_hsa005900.00753075
141Viral carcinogenesis_Homo sapiens_hsa052030.00606623
142GABAergic synapse_Homo sapiens_hsa047270.00420873
143Renin-angiotensin system_Homo sapiens_hsa04614-0.1740782
144Thyroid cancer_Homo sapiens_hsa05216-0.1730196
145Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1635307
146Serotonergic synapse_Homo sapiens_hsa04726-0.1481178
147Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1400377
148Mineral absorption_Homo sapiens_hsa04978-0.1177511
149Amoebiasis_Homo sapiens_hsa05146-0.0806515
150Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0798542
151Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0789227
152Adherens junction_Homo sapiens_hsa04520-0.0570497
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0476007
154FoxO signaling pathway_Homo sapiens_hsa04068-0.0371753
155Insulin signaling pathway_Homo sapiens_hsa04910-0.0355386
156Colorectal cancer_Homo sapiens_hsa05210-0.0161379
157N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0112328
158Gap junction_Homo sapiens_hsa04540-0.0084273
159Wnt signaling pathway_Homo sapiens_hsa04310-0.0040201
160Pathways in cancer_Homo sapiens_hsa05200-0.0002221

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »