ARID2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.29333274
2nuclear pore complex assembly (GO:0051292)5.26866876
3DNA double-strand break processing (GO:0000729)5.19756810
4mitotic sister chromatid cohesion (GO:0007064)4.82881230
5nuclear pore organization (GO:0006999)4.66969520
6protein localization to chromosome, centromeric region (GO:0071459)4.62993289
7sister chromatid segregation (GO:0000819)4.46212290
8replication fork processing (GO:0031297)4.44299934
9mitotic chromosome condensation (GO:0007076)4.41246283
10mitotic sister chromatid segregation (GO:0000070)4.40717324
11negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.40689263
12negative regulation of translation, ncRNA-mediated (GO:0040033)4.40689263
13regulation of translation, ncRNA-mediated (GO:0045974)4.40689263
14regulation of nuclear cell cycle DNA replication (GO:0033262)4.32048244
15DNA unwinding involved in DNA replication (GO:0006268)4.15282704
16regulation of telomere maintenance via telomerase (GO:0032210)4.10069990
17negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.04379887
18chromatin assembly (GO:0031497)4.04216257
19pre-miRNA processing (GO:0031054)3.99651083
20heterochromatin organization (GO:0070828)3.95820798
21regulation of meiosis I (GO:0060631)3.93503708
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.93130370
23pore complex assembly (GO:0046931)3.91210707
24DNA replication-dependent nucleosome assembly (GO:0006335)3.88808375
25DNA replication-dependent nucleosome organization (GO:0034723)3.88808375
26histone H4-K5 acetylation (GO:0043981)3.84989615
27histone H4-K8 acetylation (GO:0043982)3.84989615
28negative regulation of cell cycle G2/M phase transition (GO:1902750)3.82091604
29positive regulation of DNA-dependent DNA replication (GO:2000105)3.79725114
30regulation of histone H3-K9 methylation (GO:0051570)3.78383672
31limb bud formation (GO:0060174)3.75506722
32neural tube formation (GO:0001841)3.67874551
33centriole replication (GO:0007099)3.66152785
34mRNA stabilization (GO:0048255)3.66067247
35RNA stabilization (GO:0043489)3.66067247
36DNA duplex unwinding (GO:0032508)3.64295592
37DNA geometric change (GO:0032392)3.60737701
38maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.58866313
39histone H4-K16 acetylation (GO:0043984)3.57980823
40negative regulation of histone methylation (GO:0031061)3.56683511
41histone H4-K12 acetylation (GO:0043983)3.51613313
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.42575503
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.42575503
44protein localization to chromosome (GO:0034502)3.41385809
45protein K6-linked ubiquitination (GO:0085020)3.39391499
46regulation of centriole replication (GO:0046599)3.35393786
47recombinational repair (GO:0000725)3.33995082
48double-strand break repair via homologous recombination (GO:0000724)3.32034560
49regulation of mitotic spindle checkpoint (GO:1903504)3.31920136
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.31920136
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.31596813
52DNA replication checkpoint (GO:0000076)3.31477316
53chromosome condensation (GO:0030261)3.30665775
54kidney morphogenesis (GO:0060993)3.28027153
55chromatin assembly or disassembly (GO:0006333)3.27799860
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.26230976
57DNA conformation change (GO:0071103)3.24879495
58synapsis (GO:0007129)3.23227955
59daunorubicin metabolic process (GO:0044597)3.22164270
60polyketide metabolic process (GO:0030638)3.22164270
61doxorubicin metabolic process (GO:0044598)3.22164270
62negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.22137408
63intraciliary transport (GO:0042073)3.22122728
64regulation of sister chromatid cohesion (GO:0007063)3.20150348
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19259842
66attachment of spindle microtubules to kinetochore (GO:0008608)3.17391610
67regulation of DNA endoreduplication (GO:0032875)3.16609366
68protein prenylation (GO:0018342)3.16210779
69prenylation (GO:0097354)3.16210779
70DNA packaging (GO:0006323)3.12849302
71regulation of telomere maintenance (GO:0032204)3.12423788
72keratinocyte development (GO:0003334)3.11943221
73microtubule anchoring (GO:0034453)3.11745401
74positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11459586
75positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11459586
76positive regulation of mitotic sister chromatid separation (GO:1901970)3.11459586
77histone H2A acetylation (GO:0043968)3.11273822
78mitotic nuclear envelope disassembly (GO:0007077)3.10973192
79histone H3-K4 methylation (GO:0051568)3.09414221
80negative regulation of epidermis development (GO:0045683)3.07187427
81protein K11-linked deubiquitination (GO:0035871)3.05191457
82kinetochore organization (GO:0051383)3.04298846
83regulation of RNA export from nucleus (GO:0046831)3.01814304
84ATP-dependent chromatin remodeling (GO:0043044)3.01301455
85sister chromatid cohesion (GO:0007062)3.00195038
86DNA ligation (GO:0006266)2.98931247
87gene silencing by RNA (GO:0031047)2.96491520
88single strand break repair (GO:0000012)2.96039640
89somite rostral/caudal axis specification (GO:0032525)2.94554361
90negative regulation of DNA recombination (GO:0045910)2.93409434
91DNA catabolic process, exonucleolytic (GO:0000738)2.92933813
92DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.92123585
93membrane disassembly (GO:0030397)2.90836346
94nuclear envelope disassembly (GO:0051081)2.90836346
95DNA topological change (GO:0006265)2.90814478
96postreplication repair (GO:0006301)2.90340283
97response to pheromone (GO:0019236)2.89093490
98kinetochore assembly (GO:0051382)2.88778126
99DNA replication-independent nucleosome assembly (GO:0006336)2.87986829
100DNA replication-independent nucleosome organization (GO:0034724)2.87986829
101regulation of helicase activity (GO:0051095)2.85502153
102positive regulation of histone H3-K4 methylation (GO:0051571)2.84916309
103resolution of meiotic recombination intermediates (GO:0000712)2.84606183
104meiotic chromosome segregation (GO:0045132)2.84339692
105regulation of double-strand break repair (GO:2000779)2.83878205
106regulation of DNA-dependent DNA replication (GO:0090329)2.83139430
107regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.82490334
108monoubiquitinated protein deubiquitination (GO:0035520)2.82365728
109regulation of centrosome duplication (GO:0010824)2.81850095
110protein localization to cilium (GO:0061512)2.81546383
111regulation of mRNA stability (GO:0043488)2.81164281
112positive regulation of chromosome segregation (GO:0051984)2.79077725
113regulation of chromosome segregation (GO:0051983)2.79010898
114spindle assembly (GO:0051225)2.77998949
115mitotic metaphase plate congression (GO:0007080)2.77132088
116DNA replication initiation (GO:0006270)2.75814370
117embryonic foregut morphogenesis (GO:0048617)2.74568051
118chromosome segregation (GO:0007059)2.74426906
119NLS-bearing protein import into nucleus (GO:0006607)2.73217756
120DNA damage response, signal transduction resulting in transcription (GO:0042772)2.72553719
121maintenance of protein location in nucleus (GO:0051457)2.71957751
122regulation of cilium movement (GO:0003352)2.70836046
123regulation of centrosome cycle (GO:0046605)2.70281068
124metaphase plate congression (GO:0051310)2.70121407
125regulation of histone H3-K4 methylation (GO:0051569)2.69943495
126retinal cone cell development (GO:0046549)2.69552917
127chromatin remodeling at centromere (GO:0031055)2.69085213
128double-strand break repair via nonhomologous end joining (GO:0006303)2.69005026
129non-recombinational repair (GO:0000726)2.69005026
130histone exchange (GO:0043486)2.68194797
131positive regulation of mRNA processing (GO:0050685)2.67326185
132translesion synthesis (GO:0019985)2.66412640
133lactate metabolic process (GO:0006089)2.65952524
134dosage compensation (GO:0007549)2.65619870
135positive regulation of histone deacetylation (GO:0031065)2.65556353
136CENP-A containing nucleosome assembly (GO:0034080)2.64036797
137centrosome organization (GO:0051297)2.63353212
138regulation of RNA stability (GO:0043487)2.63227624
139double-strand break repair (GO:0006302)2.63050889
140histone H3-K9 methylation (GO:0051567)2.62227102
141spindle assembly checkpoint (GO:0071173)2.61975145
142negative regulation of telomerase activity (GO:0051974)2.61812664
143somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.61497104
144somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.61497104
145isotype switching (GO:0045190)2.61497104
146regulation of spindle organization (GO:0090224)2.61054718
147notochord development (GO:0030903)2.59920794
148regulation of mRNA 3-end processing (GO:0031440)2.58999640
149positive regulation of protein deacetylation (GO:0090312)2.58881818
150microtubule depolymerization (GO:0007019)2.58013719
151gene silencing (GO:0016458)2.57644943
152spindle checkpoint (GO:0031577)2.57600435
1533-UTR-mediated mRNA stabilization (GO:0070935)2.57312026
154microtubule organizing center organization (GO:0031023)2.56648113
155epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52659085
156mitotic G2/M transition checkpoint (GO:0044818)2.51854054
157genitalia morphogenesis (GO:0035112)2.51577708
158glial cell proliferation (GO:0014009)2.51372807
159microtubule polymerization or depolymerization (GO:0031109)2.49879238
160presynaptic membrane assembly (GO:0097105)2.49822213
161response to X-ray (GO:0010165)2.49536671
162pancreas development (GO:0031016)2.49501920
163regulation of sister chromatid segregation (GO:0033045)2.49333100
164regulation of mitotic sister chromatid separation (GO:0010965)2.49333100
165regulation of mitotic sister chromatid segregation (GO:0033047)2.49333100
166centriole assembly (GO:0098534)2.49299635
167somatic recombination of immunoglobulin gene segments (GO:0016447)2.48723849
168positive regulation of mRNA metabolic process (GO:1903313)2.47292018
169regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.47179726
170regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.47087765
171regulation of mitotic metaphase/anaphase transition (GO:0030071)2.47087765
172mitotic spindle checkpoint (GO:0071174)2.46836665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.82335841
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.61813475
3TP63_19390658_ChIP-ChIP_HaCaT_Human4.00451777
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.80695865
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.36437487
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.09671503
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.96589265
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.96589265
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.96589265
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.87136778
11* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.82022828
12* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.81073486
13ZNF274_21170338_ChIP-Seq_K562_Hela2.73698501
14IGF1R_20145208_ChIP-Seq_DFB_Human2.62112507
15FUS_26573619_Chip-Seq_HEK293_Human2.59517801
16EWS_26573619_Chip-Seq_HEK293_Human2.57807525
17VDR_22108803_ChIP-Seq_LS180_Human2.46254794
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42045747
19GBX2_23144817_ChIP-Seq_PC3_Human2.39249964
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.36899155
21TAF15_26573619_Chip-Seq_HEK293_Human2.34461433
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28148047
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.27274469
24* MYC_22102868_ChIP-Seq_BL_Human2.26666702
25P300_19829295_ChIP-Seq_ESCs_Human2.25456238
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.19691772
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12604800
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.10890667
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.03772018
30AR_21909140_ChIP-Seq_LNCAP_Human2.01828138
31MYC_18555785_ChIP-Seq_MESCs_Mouse2.01078737
32E2F7_22180533_ChIP-Seq_HELA_Human10.0944926
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98995285
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94385721
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92345262
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.90033444
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83809885
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81365598
39CIITA_25753668_ChIP-Seq_RAJI_Human1.80118975
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74340916
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71335784
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69910668
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68155643
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.66218069
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.64010981
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62820998
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62142168
48ER_23166858_ChIP-Seq_MCF-7_Human1.56785379
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.56563042
50SMAD4_21799915_ChIP-Seq_A2780_Human1.55019631
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54578145
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54240796
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52412560
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50808783
55* TCF7_22412390_ChIP-Seq_EML_Mouse1.50671125
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50660957
57TCF3_18692474_ChIP-Seq_MESCs_Mouse1.50127858
58CBP_20019798_ChIP-Seq_JUKART_Human1.49133918
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49133918
60BCAT_22108803_ChIP-Seq_LS180_Human1.48805555
61STAT3_23295773_ChIP-Seq_U87_Human1.48374905
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47808413
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46323247
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.46281457
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46269498
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45490786
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45490786
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44706628
69SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.44516028
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43903108
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.42376147
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42119638
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40987143
74SCL_19346495_ChIP-Seq_HPC-7_Human1.40152716
75AR_25329375_ChIP-Seq_VCAP_Human1.39931180
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39290795
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39164316
78KDM5A_27292631_Chip-Seq_BREAST_Human1.36489182
79SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35361457
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.35213785
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34825623
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34470597
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33664434
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33199170
85* TCF4_23295773_ChIP-Seq_U87_Human1.33174870
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32815113
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32648033
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.32039081
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.31918158
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31630599
91* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30105958
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.28954857
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28944918
94* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28886660
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.28135418
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27857595
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26762158
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26303855
99TCF4_22108803_ChIP-Seq_LS180_Human1.26246237
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24198304
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23281273
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22465589
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22433210
104MYC_18940864_ChIP-ChIP_HL60_Human1.20269032
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19606227
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19281748
107* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18781336
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18722741
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18680445
110FOXP3_21729870_ChIP-Seq_TREG_Human1.18217016
111NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17202395
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16809715
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16097861
114RUNX2_22187159_ChIP-Seq_PCA_Human1.15803597
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.14699635
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.14494541
117TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14301759
118P53_22387025_ChIP-Seq_ESCs_Mouse1.13136174
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13012205
120XRN2_22483619_ChIP-Seq_HELA_Human1.12987228
121TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.12547866
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.12372646
123* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12358878
124SOX2_19829295_ChIP-Seq_ESCs_Human1.12290245
125NANOG_19829295_ChIP-Seq_ESCs_Human1.12290245
126FLI1_21867929_ChIP-Seq_TH2_Mouse1.11960338
127SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09660917
128* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09439303
129PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09043915
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08234075
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.07990344
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07913843
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07553911
134ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07202711
135MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05971714
136CMYC_18555785_Chip-Seq_ESCs_Mouse1.04857069
137EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03822573
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03367787
139P300_18555785_Chip-Seq_ESCs_Mouse1.01958247
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01896377
141TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01782871
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00914715
143* ELK1_19687146_ChIP-ChIP_HELA_Human1.00897851
144POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00286117
145NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99966904
146EST1_17652178_ChIP-ChIP_JURKAT_Human0.99885484
147VDR_23849224_ChIP-Seq_CD4+_Human0.99578330
148CDX2_22108803_ChIP-Seq_LS180_Human0.99104929
149PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98631932
150OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97223221
151KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97067092
152IRF1_19129219_ChIP-ChIP_H3396_Human0.96870610
153CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96703027
154STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96179853
155MYB_26560356_Chip-Seq_TH1_Human0.95731274
156* CHD1_26751641_Chip-Seq_LNCaP_Human0.95150887
157NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95046173
158CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94465842
159KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94391900
160STAT3_18555785_Chip-Seq_ESCs_Mouse0.94264499
161POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94147056
162* NCOR1_26117541_ChIP-Seq_K562_Human0.93754840
163RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93629984
164ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92350710
165NANOG_16153702_ChIP-ChIP_HESCs_Human0.91782469
166VDR_21846776_ChIP-Seq_THP-1_Human0.91638853
167TTF2_22483619_ChIP-Seq_HELA_Human0.91622049
168HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91042957
169NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90856189
170POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90698937
171SOX2_16153702_ChIP-ChIP_HESCs_Human0.89296449
172KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88061607
173DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86855298
174CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83986110
175* UTX_26944678_Chip-Seq_JUKART_Human0.83512088
176HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83178723
177ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.82652333
178ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82414303
179* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82172387
180CREB1_15753290_ChIP-ChIP_HEK293T_Human0.81249131

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.76048079
2MP0010094_abnormal_chromosome_stability2.92447589
3MP0003890_abnormal_embryonic-extraembry2.90002693
4MP0009697_abnormal_copulation2.63060416
5MP0006292_abnormal_olfactory_placode2.58090673
6MP0004957_abnormal_blastocyst_morpholog2.57559732
7MP0003077_abnormal_cell_cycle2.57494644
8MP0002102_abnormal_ear_morphology2.57402222
9MP0003111_abnormal_nucleus_morphology2.56708462
10MP0003121_genomic_imprinting2.51647328
11MP0010352_gastrointestinal_tract_polyps2.36985342
12MP0004264_abnormal_extraembryonic_tissu2.22657536
13MP0005499_abnormal_olfactory_system2.22246014
14MP0005394_taste/olfaction_phenotype2.22246014
15MP0003693_abnormal_embryo_hatching2.22128800
16MP0006072_abnormal_retinal_apoptosis2.21248365
17MP0003195_calcinosis2.17744521
18MP0008877_abnormal_DNA_methylation2.01380768
19MP0001293_anophthalmia1.98284983
20MP0008007_abnormal_cellular_replicative1.91214220
21MP0001672_abnormal_embryogenesis/_devel1.88759185
22MP0005380_embryogenesis_phenotype1.88759185
23MP0003787_abnormal_imprinting1.82721689
24MP0003123_paternal_imprinting1.82712736
25MP0008789_abnormal_olfactory_epithelium1.82605188
26MP0002396_abnormal_hematopoietic_system1.82287910
27MP0000350_abnormal_cell_proliferation1.80444559
28MP0003718_maternal_effect1.78660138
29MP0003984_embryonic_growth_retardation1.78066318
30MP0002088_abnormal_embryonic_growth/wei1.77528443
31MP0008058_abnormal_DNA_repair1.77042897
32MP0003122_maternal_imprinting1.76131696
33MP0010030_abnormal_orbit_morphology1.75205400
34MP0002751_abnormal_autonomic_nervous1.74348247
35MP0005253_abnormal_eye_physiology1.73519470
36MP0002084_abnormal_developmental_patter1.69415299
37MP0004808_abnormal_hematopoietic_stem1.65156768
38MP0002085_abnormal_embryonic_tissue1.64689713
39MP0000427_abnormal_hair_cycle1.60828495
40MP0001730_embryonic_growth_arrest1.60102377
41MP0004197_abnormal_fetal_growth/weight/1.59313467
42MP0003705_abnormal_hypodermis_morpholog1.57160341
43MP0005076_abnormal_cell_differentiation1.57025087
44MP0002653_abnormal_ependyma_morphology1.55701751
45MP0005551_abnormal_eye_electrophysiolog1.54179546
46MP0002086_abnormal_extraembryonic_tissu1.52695853
47MP0002234_abnormal_pharynx_morphology1.51572322
48MP0000631_abnormal_neuroendocrine_gland1.49129066
49MP0001697_abnormal_embryo_size1.47738442
50MP0002092_abnormal_eye_morphology1.44877385
51MP0003935_abnormal_craniofacial_develop1.39580946
52MP0003937_abnormal_limbs/digits/tail_de1.37644889
53MP0005645_abnormal_hypothalamus_physiol1.36214036
54MP0008932_abnormal_embryonic_tissue1.32364916
55MP0000647_abnormal_sebaceous_gland1.31699253
56MP0004043_abnormal_pH_regulation1.29050613
57MP0001849_ear_inflammation1.28770405
58MP0000432_abnormal_head_morphology1.28280364
59MP0000428_abnormal_craniofacial_morphol1.25591678
60MP0005410_abnormal_fertilization1.25029448
61MP0002233_abnormal_nose_morphology1.21773798
62MP0000537_abnormal_urethra_morphology1.20544714
63MP0002210_abnormal_sex_determination1.20506530
64MP0000049_abnormal_middle_ear1.20446241
65MP0001984_abnormal_olfaction1.20110644
66MP0001929_abnormal_gametogenesis1.19757693
67MP0001177_atelectasis1.18437021
68MP0001188_hyperpigmentation1.17443075
69MP0002080_prenatal_lethality1.16992233
70MP0003943_abnormal_hepatobiliary_system1.16939855
71MP0003880_abnormal_central_pattern1.15325104
72MP0003011_delayed_dark_adaptation1.15039983
73MP0002163_abnormal_gland_morphology1.14917115
74MP0010307_abnormal_tumor_latency1.13114457
75MP0002938_white_spotting1.13061881
76MP0003755_abnormal_palate_morphology1.12967334
77MP0009703_decreased_birth_body1.12914498
78MP0002932_abnormal_joint_morphology1.12185224
79MP0001145_abnormal_male_reproductive1.11432211
80MP0002925_abnormal_cardiovascular_devel1.09964242
81MP0000313_abnormal_cell_death1.08452103
82MP0000372_irregular_coat_pigmentation1.08002631
83MP0003315_abnormal_perineum_morphology1.07818843
84MP0000490_abnormal_crypts_of1.07798522
85MP0000569_abnormal_digit_pigmentation1.07677540
86MP0001286_abnormal_eye_development1.07185018
87MP0002282_abnormal_trachea_morphology1.07096865
88MP0000383_abnormal_hair_follicle1.07091907
89MP0003119_abnormal_digestive_system1.06821743
90MP0002254_reproductive_system_inflammat1.06639925
91MP0003567_abnormal_fetal_cardiomyocyte1.03788655
92MP0009278_abnormal_bone_marrow1.03204459
93MP0002736_abnormal_nociception_after1.02831291
94MP0008995_early_reproductive_senescence1.02385489
95MP0005220_abnormal_exocrine_pancreas1.01861241
96MP0002116_abnormal_craniofacial_bone0.99880053
97MP0005075_abnormal_melanosome_morpholog0.99280049
98MP0001485_abnormal_pinna_reflex0.98943119
99MP0000778_abnormal_nervous_system0.98653589
100MP0004133_heterotaxia0.98415050
101MP0005646_abnormal_pituitary_gland0.98328423
102MP0008872_abnormal_physiological_respon0.98089024
103MP0002090_abnormal_vision0.98024101
104MP0003698_abnormal_male_reproductive0.96732643
105MP0003938_abnormal_ear_development0.96423089
106MP0005248_abnormal_Harderian_gland0.96293260
107MP0002009_preneoplasia0.96038642
108MP0005187_abnormal_penis_morphology0.95843130
109MP0002114_abnormal_axial_skeleton0.95661079
110MP0005174_abnormal_tail_pigmentation0.95301732
111MP0001119_abnormal_female_reproductive0.94762884
112MP0003786_premature_aging0.93880179
113MP0000678_abnormal_parathyroid_gland0.93682095
114MP0005391_vision/eye_phenotype0.93250419
115MP0002697_abnormal_eye_size0.92810394
116MP0001529_abnormal_vocalization0.91685153
117MP0006054_spinal_hemorrhage0.91394790
118MP0000703_abnormal_thymus_morphology0.91269112
119MP0005257_abnormal_intraocular_pressure0.90167429
120MP0003942_abnormal_urinary_system0.89928298
121MP0003861_abnormal_nervous_system0.89458966
122MP0005395_other_phenotype0.89143680
123MP0001545_abnormal_hematopoietic_system0.89111810
124MP0005397_hematopoietic_system_phenotyp0.89111810
125MP0000653_abnormal_sex_gland0.88383938
126MP0004215_abnormal_myocardial_fiber0.87689192
127MP0009053_abnormal_anal_canal0.86968119
128MP0009672_abnormal_birth_weight0.85637571
129MP0005379_endocrine/exocrine_gland_phen0.85353432
130MP0002098_abnormal_vibrissa_morphology0.85287960
131MP0005367_renal/urinary_system_phenotyp0.84698536
132MP0000516_abnormal_urinary_system0.84698536
133MP0003941_abnormal_skin_development0.84047216
134MP0002837_dystrophic_cardiac_calcinosis0.82164749
135MP0000733_abnormal_muscle_development0.81512006
136MP0009046_muscle_twitch0.81086831
137MP0002160_abnormal_reproductive_system0.80424809
138MP0002249_abnormal_larynx_morphology0.80316114
139MP0010678_abnormal_skin_adnexa0.79726589
140MP0005195_abnormal_posterior_eye0.79349254
141MP0002019_abnormal_tumor_incidence0.79240915
142MP0005389_reproductive_system_phenotype0.78656212
143MP0003115_abnormal_respiratory_system0.78628092
144MP0005623_abnormal_meninges_morphology0.77989891
145MP0010234_abnormal_vibrissa_follicle0.77614674
146MP0002127_abnormal_cardiovascular_syste0.77152367
147MP0006276_abnormal_autonomic_nervous0.76712650
148MP0002184_abnormal_innervation0.75802850

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.77097929
2Volvulus (HP:0002580)3.74444032
3Chromsome breakage (HP:0040012)3.66872556
4Bilateral microphthalmos (HP:0007633)3.51627903
5Pancreatic cysts (HP:0001737)3.42973089
6Hypochromic microcytic anemia (HP:0004840)3.39059898
7Intestinal atresia (HP:0011100)3.33154451
8Hepatoblastoma (HP:0002884)3.25987324
9Pancreatic fibrosis (HP:0100732)3.22073730
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.21272425
11Short 4th metacarpal (HP:0010044)3.21272425
12Abnormality of the labia minora (HP:0012880)3.20540981
13True hermaphroditism (HP:0010459)3.12190047
14Nephroblastoma (Wilms tumor) (HP:0002667)3.08309702
15Nephronophthisis (HP:0000090)3.02001262
16Ependymoma (HP:0002888)2.97563692
17Chronic hepatic failure (HP:0100626)2.97068947
18Embryonal renal neoplasm (HP:0011794)2.89416028
19Rib fusion (HP:0000902)2.89123745
20Abnormality of the fingertips (HP:0001211)2.81190659
21Aqueductal stenosis (HP:0002410)2.78346539
22Neoplasm of the adrenal cortex (HP:0100641)2.78336752
23Ectopic kidney (HP:0000086)2.77604018
24Abnormality of the renal medulla (HP:0100957)2.71866984
25Meckel diverticulum (HP:0002245)2.62661412
26Abnormality of midbrain morphology (HP:0002418)2.62251683
27Molar tooth sign on MRI (HP:0002419)2.62251683
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.60997428
29Abnormal lung lobation (HP:0002101)2.60409239
30Impulsivity (HP:0100710)2.56851496
31Medulloblastoma (HP:0002885)2.55373547
32Neoplasm of striated muscle (HP:0009728)2.53351824
33Aplasia/Hypoplasia of the sternum (HP:0006714)2.51489443
34Increased nuchal translucency (HP:0010880)2.50442844
35Bifid tongue (HP:0010297)2.45791071
36Abnormality of the ileum (HP:0001549)2.44573376
37Renal duplication (HP:0000075)2.43497386
38Rhabdomyosarcoma (HP:0002859)2.40589811
39Abnormality of chromosome segregation (HP:0002916)2.40364225
40Abnormality of the lower motor neuron (HP:0002366)2.39457056
41Abnormality of the astrocytes (HP:0100707)2.37665350
42Astrocytoma (HP:0009592)2.37665350
43Abnormality of the renal cortex (HP:0011035)2.37332559
44Neoplasm of the oral cavity (HP:0100649)2.35828615
45Oligodactyly (hands) (HP:0001180)2.34998159
46Papillary thyroid carcinoma (HP:0002895)2.33714938
47Clubbing of toes (HP:0100760)2.30205563
48Skin tags (HP:0010609)2.30072656
49Thyroiditis (HP:0100646)2.29304678
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.28855886
51Postaxial foot polydactyly (HP:0001830)2.28335891
52Long eyelashes (HP:0000527)2.26696154
53Abnormality of the 4th metacarpal (HP:0010012)2.26216069
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.25303110
55Abnormality of chromosome stability (HP:0003220)2.21188906
56Tubulointerstitial nephritis (HP:0001970)2.20567143
57Broad palm (HP:0001169)2.20205824
58Shawl scrotum (HP:0000049)2.20103402
59Cystic liver disease (HP:0006706)2.18981084
60Preauricular skin tag (HP:0000384)2.18347072
61Supernumerary ribs (HP:0005815)2.18284413
62Absent frontal sinuses (HP:0002688)2.16937801
63Atresia of the external auditory canal (HP:0000413)2.16515391
64Supernumerary spleens (HP:0009799)2.13796153
65Prominent nose (HP:0000448)2.12966815
66Small intestinal stenosis (HP:0012848)2.12604200
67Duodenal stenosis (HP:0100867)2.12604200
68Medial flaring of the eyebrow (HP:0010747)2.12526006
69Bile duct proliferation (HP:0001408)2.11713113
70Abnormal biliary tract physiology (HP:0012439)2.11713113
71Preaxial hand polydactyly (HP:0001177)2.10173843
72Myelodysplasia (HP:0002863)2.06951557
73Lip pit (HP:0100267)2.05780075
74Colon cancer (HP:0003003)2.05445374
75Hypoplastic labia majora (HP:0000059)2.03977799
76Dandy-Walker malformation (HP:0001305)2.03721989
77Abnormality of the phalanges of the hallux (HP:0010057)2.03158558
78Intestinal fistula (HP:0100819)2.02770521
79Abnormality of the distal phalanx of the thumb (HP:0009617)1.99601261
80Macroorchidism (HP:0000053)1.97897966
81Deep philtrum (HP:0002002)1.97693809
82Missing ribs (HP:0000921)1.97557446
83Selective tooth agenesis (HP:0001592)1.97522981
84Glioma (HP:0009733)1.97498503
85Anencephaly (HP:0002323)1.96304065
86Genital tract atresia (HP:0001827)1.96081805
87Pendular nystagmus (HP:0012043)1.95309959
88Abnormality of the preputium (HP:0100587)1.94986742
89Small hand (HP:0200055)1.94918199
90Hypothermia (HP:0002045)1.94088107
91Supernumerary bones of the axial skeleton (HP:0009144)1.93561321
92Gastrointestinal atresia (HP:0002589)1.93425871
93Heterotopia (HP:0002282)1.91841731
94Sloping forehead (HP:0000340)1.91501283
95Renal cortical cysts (HP:0000803)1.91313430
96Triphalangeal thumb (HP:0001199)1.90835360
97Abnormality of the intervertebral disk (HP:0005108)1.90801421
98Renal hypoplasia (HP:0000089)1.90369194
99Pancreatic islet-cell hyperplasia (HP:0004510)1.89193129
100Facial cleft (HP:0002006)1.87773607
101Malignant gastrointestinal tract tumors (HP:0006749)1.87576052
102Gastrointestinal carcinoma (HP:0002672)1.87576052
103Abnormality of the carotid arteries (HP:0005344)1.86971128
104Truncal obesity (HP:0001956)1.86944297
105Embryonal neoplasm (HP:0002898)1.86137845
106Proximal placement of thumb (HP:0009623)1.85903597
107Postaxial hand polydactyly (HP:0001162)1.85538821
108Broad thumb (HP:0011304)1.85293417
109Vaginal atresia (HP:0000148)1.85031484
110Short humerus (HP:0005792)1.84679208
111Anophthalmia (HP:0000528)1.84664032
112Optic nerve hypoplasia (HP:0000609)1.84549675
113Short 5th finger (HP:0009237)1.83095993
114Breast carcinoma (HP:0003002)1.81064468
115Leiomyosarcoma (HP:0100243)1.80864495
116Uterine leiomyosarcoma (HP:0002891)1.80864495
117Abnormality of the labia majora (HP:0012881)1.80752467
118Congenital stationary night blindness (HP:0007642)1.80127027
119Fair hair (HP:0002286)1.79728465
120Facial hemangioma (HP:0000329)1.79151668
121Labial hypoplasia (HP:0000066)1.79078329
122Aplasia/hypoplasia of the humerus (HP:0006507)1.78951462
123Sclerocornea (HP:0000647)1.78568419
124Deviation of the thumb (HP:0009603)1.78174185
125Male pseudohermaphroditism (HP:0000037)1.77194380
126Abnormality of the duodenum (HP:0002246)1.76545110
127Hyperventilation (HP:0002883)1.76242434
128Patellar aplasia (HP:0006443)1.76000530
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75743941
130Transitional cell carcinoma of the bladder (HP:0006740)1.74346311
131Skin pits (HP:0100276)1.73922177
132Astigmatism (HP:0000483)1.73697005
133Narrow forehead (HP:0000341)1.73608344
134Abnormal number of incisors (HP:0011064)1.73290236
135Cupped ear (HP:0000378)1.73147660
136Abnormality of the parathyroid morphology (HP:0011766)1.72351305
137Absent radius (HP:0003974)1.72238130
138Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72084962
139Periauricular skin pits (HP:0100277)1.71660171
140Preauricular pit (HP:0004467)1.71660171
141Sandal gap (HP:0001852)1.71384679
142Dislocated radial head (HP:0003083)1.71276332
143Hypoplastic female external genitalia (HP:0012815)1.70924103
144Rectovaginal fistula (HP:0000143)1.70549397
145Rectal fistula (HP:0100590)1.70549397
146Progressive inability to walk (HP:0002505)1.70276463
147Cutis marmorata (HP:0000965)1.69304110
148Gonadotropin excess (HP:0000837)1.69229893
149Growth hormone deficiency (HP:0000824)1.68445117
150Large earlobe (HP:0009748)1.67885759
151Gaze-evoked nystagmus (HP:0000640)1.67242746
152Congenital primary aphakia (HP:0007707)1.66973412
153Congenital hepatic fibrosis (HP:0002612)1.66288294
154Oligodactyly (HP:0012165)1.65926513
155Nasal polyposis (HP:0100582)1.64918943
15611 pairs of ribs (HP:0000878)1.64289924
157Methylmalonic acidemia (HP:0002912)1.64095104
158Abnormal pancreas size (HP:0012094)1.62963465
159Abnormality of endocrine pancreas physiology (HP:0012093)1.62728453
160Abnormality of the pancreatic islet cells (HP:0006476)1.62728453
161Abnormal hair whorl (HP:0010721)1.62306045
162Amyotrophic lateral sclerosis (HP:0007354)1.61714406
163Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.61619241
164Absent forearm bone (HP:0003953)1.61283158
165Aplasia involving forearm bones (HP:0009822)1.61283158
166Abnormality of the radial head (HP:0003995)1.60794387
167Highly arched eyebrow (HP:0002553)1.60672909
168Thyroid carcinoma (HP:0002890)1.60356124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.73175798
2CDC73.66695447
3NEK23.05642229
4MAP3K102.78324355
5TTK2.66817477
6TRIM282.65205441
7MAP4K22.63860761
8EIF2AK32.54711449
9WNK32.49247957
10TNIK2.43667960
11BMPR1B2.30249250
12BRD42.08211344
13GRK61.93625470
14STK101.90558291
15LATS11.88649345
16MST41.81886796
17CHEK21.78045889
18ERN11.76862287
19CDK71.75568083
20WEE11.75535788
21CSF1R1.72389208
22EEF2K1.66526006
23CASK1.66055650
24PLK21.63664122
25TYRO31.61287951
26PNCK1.60018463
27SRPK11.59176499
28CHEK11.53209475
29PLK11.52983241
30STK31.51778723
31TAF11.50652157
32ATR1.44933082
33FGFR31.44514341
34STK391.42705878
35MAP3K41.35732752
36MKNK11.34189443
37MKNK21.33486142
38BCR1.32197098
39STK41.29021827
40MTOR1.23525816
41TGFBR21.22725515
42AURKB1.22451586
43ACVR1B1.22123882
44TSSK61.22114256
45DYRK31.21590396
46GRK11.21137373
47ATM1.20923942
48ICK1.19509186
49WNK11.18705274
50CDK41.16854494
51RPS6KB21.15650171
52BRSK21.15403469
53INSRR1.15177601
54HIPK21.13425455
55OXSR11.11921270
56GRK51.09462988
57MAPK131.08363807
58NLK1.07215514
59EIF2AK11.06428348
60PLK41.00946616
61CDK20.98771000
62PASK0.97371635
63CAMK1D0.97176272
64MAPK70.96959819
65EPHA40.94352398
66PDK40.94292829
67PDK30.94292829
68NEK10.94208574
69CAMK1G0.91163731
70CDK60.90095316
71CSNK1G10.90022022
72MARK20.88968542
73FER0.85045317
74ERBB30.84028161
75PAK40.83298693
76VRK20.82627749
77IRAK10.80924414
78STK38L0.80149392
79MATK0.78417915
80CDK10.77457958
81PRKD30.74433188
82CAMK40.73935293
83PAK30.73091662
84ZAK0.72183866
85CDK90.71227213
86PLK30.69457597
87CLK10.68252123
88SGK20.66415255
89PBK0.65550473
90BUB10.63893381
91PKN20.63752545
92CSNK1A1L0.63458318
93RPS6KA40.63345281
94MELK0.62135940
95CSNK1G20.62004774
96PRKCE0.59706315
97ALK0.59687652
98MAP3K80.59419563
99TGFBR10.59180799
100YES10.59149059
101CSNK1G30.58279846
102MAPK140.57931100
103PDGFRA0.57332484
104NUAK10.55607378
105IRAK20.54966551
106CHUK0.53589983
107PIM10.53250743
108AKT20.52914334
109SIK20.51317083
110CDK30.50639554
111FRK0.49906193
112WNK40.48737893
113PDGFRB0.48334754
114AKT30.47773176
115GSK3B0.47250822
116FGFR20.47112748
117EPHA20.46933769
118PINK10.46431316
119VRK10.45971115
120ADRBK20.45548144
121DYRK1B0.45462017
122FLT30.44595773
123AKT10.44379542
124STK160.43669514
125BRSK10.43602247
126ERBB20.42881355
127STK240.41256743
128EIF2AK20.39761926
129DYRK20.39024306
130PRKCG0.38819580
131MAPK10.38729503
132TEC0.38394685
133FGFR10.37530080
134PRKDC0.35498545
135TLK10.35060122
136CSK0.34661063
137CSNK1D0.34648053
138TESK10.33649630
139CCNB10.33338350
140CSNK1E0.32318315
141MAP3K70.31620778
142MUSK0.31093570
143AURKA0.30769310
144MAPK100.30284524
145MARK10.29938406
146DYRK1A0.28438596
147OBSCN0.28007545
148NTRK30.26421790
149CSNK1A10.25032565
150MINK10.22065742

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.89749808
2Cell cycle_Homo sapiens_hsa041102.81214518
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69564365
4mRNA surveillance pathway_Homo sapiens_hsa030152.68347276
5Fanconi anemia pathway_Homo sapiens_hsa034602.64836342
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54209773
7Protein export_Homo sapiens_hsa030602.52030457
8RNA transport_Homo sapiens_hsa030132.51680543
9Mismatch repair_Homo sapiens_hsa034302.50078718
10Propanoate metabolism_Homo sapiens_hsa006402.37627123
11Spliceosome_Homo sapiens_hsa030402.35693393
12Homologous recombination_Homo sapiens_hsa034402.13932484
13Non-homologous end-joining_Homo sapiens_hsa034502.08304303
14Base excision repair_Homo sapiens_hsa034102.04078467
15RNA degradation_Homo sapiens_hsa030181.88971569
16Butanoate metabolism_Homo sapiens_hsa006501.74684799
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72570195
18Phototransduction_Homo sapiens_hsa047441.71558350
19Basal transcription factors_Homo sapiens_hsa030221.68787005
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66705348
21MicroRNAs in cancer_Homo sapiens_hsa052061.62438052
22Basal cell carcinoma_Homo sapiens_hsa052171.62401530
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.61679877
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.60940307
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58515537
26Nucleotide excision repair_Homo sapiens_hsa034201.57819839
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.53045154
28p53 signaling pathway_Homo sapiens_hsa041151.50031050
29Proteasome_Homo sapiens_hsa030501.45995110
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40331546
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.38078477
32Steroid biosynthesis_Homo sapiens_hsa001001.36417677
33Herpes simplex infection_Homo sapiens_hsa051681.34129991
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33682910
35Thyroid cancer_Homo sapiens_hsa052161.33418962
36Nitrogen metabolism_Homo sapiens_hsa009101.30741661
37mTOR signaling pathway_Homo sapiens_hsa041501.28633079
38Adherens junction_Homo sapiens_hsa045201.28182449
39Ether lipid metabolism_Homo sapiens_hsa005651.26217239
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26173162
41Notch signaling pathway_Homo sapiens_hsa043301.24844730
42Viral carcinogenesis_Homo sapiens_hsa052031.23902428
43Small cell lung cancer_Homo sapiens_hsa052221.22937010
44Systemic lupus erythematosus_Homo sapiens_hsa053221.22398623
45HTLV-I infection_Homo sapiens_hsa051661.21087218
46Lysine degradation_Homo sapiens_hsa003101.19585424
47Colorectal cancer_Homo sapiens_hsa052101.18926181
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18201531
49Caffeine metabolism_Homo sapiens_hsa002321.17068605
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16450925
51Oocyte meiosis_Homo sapiens_hsa041141.15081988
52Hedgehog signaling pathway_Homo sapiens_hsa043401.14883483
53One carbon pool by folate_Homo sapiens_hsa006701.12418883
54Hippo signaling pathway_Homo sapiens_hsa043901.12294757
55Nicotine addiction_Homo sapiens_hsa050331.12059817
56Circadian rhythm_Homo sapiens_hsa047101.11648355
57Chronic myeloid leukemia_Homo sapiens_hsa052201.09876930
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08456140
59Vitamin B6 metabolism_Homo sapiens_hsa007501.06572974
60Wnt signaling pathway_Homo sapiens_hsa043101.06570567
61TGF-beta signaling pathway_Homo sapiens_hsa043501.05064178
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.03769430
63Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03434833
64Fatty acid elongation_Homo sapiens_hsa000621.02879413
65Pathways in cancer_Homo sapiens_hsa052001.02159653
66Endometrial cancer_Homo sapiens_hsa052131.01417133
67Acute myeloid leukemia_Homo sapiens_hsa052211.00549830
68Prostate cancer_Homo sapiens_hsa052150.99200329
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98590941
70Pancreatic cancer_Homo sapiens_hsa052120.93261554
71Non-small cell lung cancer_Homo sapiens_hsa052230.92982475
72Tryptophan metabolism_Homo sapiens_hsa003800.92149463
73Dorso-ventral axis formation_Homo sapiens_hsa043200.90796948
74Linoleic acid metabolism_Homo sapiens_hsa005910.88459215
75RNA polymerase_Homo sapiens_hsa030200.85675689
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83214322
77Proteoglycans in cancer_Homo sapiens_hsa052050.82885953
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82371956
79Taste transduction_Homo sapiens_hsa047420.80341994
80Epstein-Barr virus infection_Homo sapiens_hsa051690.78152034
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77615762
82Purine metabolism_Homo sapiens_hsa002300.77018253
83Pyrimidine metabolism_Homo sapiens_hsa002400.76025971
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.75806101
85Viral myocarditis_Homo sapiens_hsa054160.75637227
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74857664
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.74637322
88Primary immunodeficiency_Homo sapiens_hsa053400.74003122
89Alcoholism_Homo sapiens_hsa050340.73799738
90Olfactory transduction_Homo sapiens_hsa047400.73097273
91B cell receptor signaling pathway_Homo sapiens_hsa046620.72981139
92Antigen processing and presentation_Homo sapiens_hsa046120.72977838
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71311223
94Hepatitis B_Homo sapiens_hsa051610.68860550
95Peroxisome_Homo sapiens_hsa041460.68028855
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.67725932
97FoxO signaling pathway_Homo sapiens_hsa040680.66840609
98Regulation of autophagy_Homo sapiens_hsa041400.66565720
99Inositol phosphate metabolism_Homo sapiens_hsa005620.65031303
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64691158
101T cell receptor signaling pathway_Homo sapiens_hsa046600.63354857
102Influenza A_Homo sapiens_hsa051640.60128304
103Toxoplasmosis_Homo sapiens_hsa051450.57977086
104Retinol metabolism_Homo sapiens_hsa008300.57859348
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.57810132
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56788610
107Ribosome_Homo sapiens_hsa030100.56420355
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55952039
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55825335
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55714126
111Measles_Homo sapiens_hsa051620.55428265
112Focal adhesion_Homo sapiens_hsa045100.55373065
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55089802
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54692840
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54490647
116Fatty acid metabolism_Homo sapiens_hsa012120.54171867
117Apoptosis_Homo sapiens_hsa042100.54119847
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53821343
119AMPK signaling pathway_Homo sapiens_hsa041520.53775930
120Fructose and mannose metabolism_Homo sapiens_hsa000510.53710653
121Selenocompound metabolism_Homo sapiens_hsa004500.53087264
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52676674
123Prolactin signaling pathway_Homo sapiens_hsa049170.52444875
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50868281
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.50015808
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49830120
127beta-Alanine metabolism_Homo sapiens_hsa004100.49529921
128Tight junction_Homo sapiens_hsa045300.49029867
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48761971
130Renal cell carcinoma_Homo sapiens_hsa052110.48677234
131Chemical carcinogenesis_Homo sapiens_hsa052040.48118593
132Insulin resistance_Homo sapiens_hsa049310.47780594
133Melanoma_Homo sapiens_hsa052180.45553962
134Vitamin digestion and absorption_Homo sapiens_hsa049770.44851114
135Rap1 signaling pathway_Homo sapiens_hsa040150.44670440
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44326248
137Pyruvate metabolism_Homo sapiens_hsa006200.44071039
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43731830
139Hematopoietic cell lineage_Homo sapiens_hsa046400.43545995
140Glioma_Homo sapiens_hsa052140.43232608
141Bladder cancer_Homo sapiens_hsa052190.42616813
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.41878836
143ABC transporters_Homo sapiens_hsa020100.41749005
144Serotonergic synapse_Homo sapiens_hsa047260.40881940
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40321804
146Fatty acid degradation_Homo sapiens_hsa000710.39991241
147HIF-1 signaling pathway_Homo sapiens_hsa040660.39563187
148Long-term depression_Homo sapiens_hsa047300.39496737
149Choline metabolism in cancer_Homo sapiens_hsa052310.39396226
150Insulin secretion_Homo sapiens_hsa049110.38340273
151Galactose metabolism_Homo sapiens_hsa000520.36082334
152Metabolic pathways_Homo sapiens_hsa011000.32032100
153Primary bile acid biosynthesis_Homo sapiens_hsa001200.31860616
154Glycerolipid metabolism_Homo sapiens_hsa005610.31629978
155Huntingtons disease_Homo sapiens_hsa050160.30048967
156Circadian entrainment_Homo sapiens_hsa047130.28899397
157Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27698511
158Glutamatergic synapse_Homo sapiens_hsa047240.23746659

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