ARID1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.89952188
2negative regulation of histone methylation (GO:0031061)4.35083999
3mitotic sister chromatid cohesion (GO:0007064)4.31263859
4nuclear pore complex assembly (GO:0051292)4.18453481
5regulation of NFAT protein import into nucleus (GO:0051532)4.03970858
6nuclear pore organization (GO:0006999)3.92950039
7histone H3-K9 modification (GO:0061647)3.77823799
8histone H3-K4 methylation (GO:0051568)3.67404831
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.65189782
10negative thymic T cell selection (GO:0045060)3.61754223
11regulation of RNA export from nucleus (GO:0046831)3.60425987
12protein localization to kinetochore (GO:0034501)3.54391592
13DNA unwinding involved in DNA replication (GO:0006268)3.49441419
14negative T cell selection (GO:0043383)3.48976801
15regulation of histone H3-K9 methylation (GO:0051570)3.47869581
16histone lysine demethylation (GO:0070076)3.45048481
17negative regulation of RNA splicing (GO:0033119)3.37858314
18peptidyl-lysine methylation (GO:0018022)3.36319133
19histone H3-K4 trimethylation (GO:0080182)3.36048198
20mitotic nuclear envelope disassembly (GO:0007077)3.30815623
21regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.30641310
22positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.30641310
23heterochromatin organization (GO:0070828)3.25801356
24histone demethylation (GO:0016577)3.24138046
25thymic T cell selection (GO:0045061)3.24004190
26protein localization to chromosome, centromeric region (GO:0071459)3.19545277
27pore complex assembly (GO:0046931)3.18171120
28RNA stabilization (GO:0043489)3.16161448
29mRNA stabilization (GO:0048255)3.16161448
30negative regulation of mRNA processing (GO:0050686)3.16017615
31positive T cell selection (GO:0043368)3.15993066
32DNA topological change (GO:0006265)3.15750515
33dosage compensation (GO:0007549)3.15644537
34histone H4-K12 acetylation (GO:0043983)3.15103704
35DNA methylation (GO:0006306)3.13350473
36DNA alkylation (GO:0006305)3.13350473
37sister chromatid segregation (GO:0000819)3.11644635
38positive regulation of granulocyte differentiation (GO:0030854)3.11170079
39mitotic chromosome condensation (GO:0007076)3.10787111
40nuclear envelope disassembly (GO:0051081)3.08806191
41membrane disassembly (GO:0030397)3.08806191
42alternative mRNA splicing, via spliceosome (GO:0000380)3.08599256
43regulation of sister chromatid cohesion (GO:0007063)3.05540823
44positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.04213205
45regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.04213205
46cytoplasmic mRNA processing body assembly (GO:0033962)3.04003392
47negative regulation of DNA repair (GO:0045738)3.02935283
48T cell selection (GO:0045058)3.01198829
49histone H2A monoubiquitination (GO:0035518)2.98995618
50monoubiquitinated protein deubiquitination (GO:0035520)2.98909032
51regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98506325
52positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.98357382
53negative regulation of mRNA metabolic process (GO:1903312)2.97140115
54negative regulation of histone modification (GO:0031057)2.95858586
55histone deubiquitination (GO:0016578)2.95757626
56regulation of histone H3-K4 methylation (GO:0051569)2.95327804
57somatic stem cell division (GO:0048103)2.95233023
58histone lysine methylation (GO:0034968)2.95183483
59histone H3-K9 demethylation (GO:0033169)2.95033661
60DNA duplex unwinding (GO:0032508)2.94691506
61DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.92975118
62DNA geometric change (GO:0032392)2.92849069
63mitotic sister chromatid segregation (GO:0000070)2.91846528
64regulation of chromatin binding (GO:0035561)2.89903464
65positive regulation of histone deacetylation (GO:0031065)2.88393996
66regulation of histone methylation (GO:0031060)2.88301845
67positive regulation of chromosome segregation (GO:0051984)2.87906406
68peptidyl-lysine trimethylation (GO:0018023)2.86112919
69protein dealkylation (GO:0008214)2.85278765
70protein demethylation (GO:0006482)2.85278765
71histone H4-K16 acetylation (GO:0043984)2.83802014
72kinetochore organization (GO:0051383)2.83783153
73internal peptidyl-lysine acetylation (GO:0018393)2.82798718
74regulation of spindle organization (GO:0090224)2.81997056
75regulation of histone H3-K27 methylation (GO:0061085)2.81849187
76negative regulation of chromatin modification (GO:1903309)2.81434764
77positive regulation of gamma-delta T cell activation (GO:0046645)2.80540162
78positive regulation of CREB transcription factor activity (GO:0032793)2.80419530
79regulation of gamma-delta T cell activation (GO:0046643)2.80287673
80positive regulation of mRNA catabolic process (GO:0061014)2.78157583
81embryonic camera-type eye morphogenesis (GO:0048596)2.76833252
82DNA damage response, signal transduction resulting in transcription (GO:0042772)2.76182249
83stress granule assembly (GO:0034063)2.76169944
84histone methylation (GO:0016571)2.75803260
85* positive regulation of gene expression, epigenetic (GO:0045815)2.75147204
86peptidyl-lysine acetylation (GO:0018394)2.75042752
87positive regulation of mitotic sister chromatid separation (GO:1901970)2.74693623
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.74693623
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.74693623
90negative regulation of erythrocyte differentiation (GO:0045647)2.74241126
91positive regulation by host of viral transcription (GO:0043923)2.73687166
92regulation of nucleobase-containing compound transport (GO:0032239)2.73485381
93histone H4 acetylation (GO:0043967)2.73165390
943-UTR-mediated mRNA stabilization (GO:0070935)2.72703968
95* protein-DNA complex disassembly (GO:0032986)2.72494894
96* nucleosome disassembly (GO:0006337)2.72494894
97embryonic retina morphogenesis in camera-type eye (GO:0060059)2.72451479
98regulation of mRNA catabolic process (GO:0061013)2.72002716
99V(D)J recombination (GO:0033151)2.71932107
100regulation of mRNA stability (GO:0043488)2.71921621
101planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71386730
102regulation of gamma-delta T cell differentiation (GO:0045586)2.70852031
103mitotic metaphase plate congression (GO:0007080)2.69381897
104protein localization to chromosome (GO:0034502)2.68782128
105negative regulation of translation, ncRNA-mediated (GO:0040033)2.68534015
106regulation of translation, ncRNA-mediated (GO:0045974)2.68534015
107negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68534015
108negative regulation of gene expression, epigenetic (GO:0045814)2.67605471
109positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.66946843
110chromatin assembly (GO:0031497)2.65996040
111chromatin silencing (GO:0006342)2.65164247
112mRNA splice site selection (GO:0006376)2.65092214
113interkinetic nuclear migration (GO:0022027)2.65011172
114regulation of DNA damage checkpoint (GO:2000001)2.64445450
115histone H3-K9 methylation (GO:0051567)2.64372925
116histone H3-K36 demethylation (GO:0070544)2.63763694
117histone mRNA catabolic process (GO:0071044)2.63429445
118positive thymic T cell selection (GO:0045059)2.63359312
119positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.62959267
120histone H4-K8 acetylation (GO:0043982)2.62201840
121histone H4-K5 acetylation (GO:0043981)2.62201840
122regulation of DNA endoreduplication (GO:0032875)2.61852649
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.60756489
124regulation of mitotic spindle organization (GO:0060236)2.60418330
125NLS-bearing protein import into nucleus (GO:0006607)2.59219509
126regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.58265953
127regulation of gene silencing by RNA (GO:0060966)2.58182917
128regulation of posttranscriptional gene silencing (GO:0060147)2.58182917
129regulation of gene silencing by miRNA (GO:0060964)2.58182917
130positive regulation of RNA splicing (GO:0033120)2.58174880
131regulation of RNA stability (GO:0043487)2.57979709
132histone H4 deacetylation (GO:0070933)2.57783094
133chromatin assembly or disassembly (GO:0006333)2.57186790
134regulation of chromatin silencing (GO:0031935)2.56738254
135gene silencing (GO:0016458)2.56380072
136internal protein amino acid acetylation (GO:0006475)2.55156458
137histone H2A acetylation (GO:0043968)2.54778951
138positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.54605009
139positive regulation of cell cycle G2/M phase transition (GO:1902751)2.54605009
140modulation by host of symbiont transcription (GO:0052472)2.54088067
141modulation by host of viral transcription (GO:0043921)2.54088067
142histone acetylation (GO:0016573)2.53744708
143covalent chromatin modification (GO:0016569)2.53687828
144inner cell mass cell proliferation (GO:0001833)2.53544153
145regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53237689
146regulation of stem cell maintenance (GO:2000036)2.53224589
147histone modification (GO:0016570)2.53193636
148RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.53100153
149mRNA splicing, via spliceosome (GO:0000398)2.53100153
150peptidyl-threonine phosphorylation (GO:0018107)2.51793027
151Peyers patch development (GO:0048541)2.51396284
152mucosal-associated lymphoid tissue development (GO:0048537)2.51396284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.05381360
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.50552724
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.37382863
4* MYC_22102868_ChIP-Seq_BL_Human4.20955183
5EZH2_22144423_ChIP-Seq_EOC_Human4.01633537
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40720019
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.17529234
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03816684
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.94947758
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59777031
11VDR_21846776_ChIP-Seq_THP-1_Human2.55811811
12* CIITA_25753668_ChIP-Seq_RAJI_Human2.52949525
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38249111
14* TCF7_22412390_ChIP-Seq_EML_Mouse2.34309823
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31830537
16* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24902793
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.11793030
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.07738639
19* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.01357167
20* KDM2B_26808549_Chip-Seq_DND41_Human1.95499923
21SCL_19346495_ChIP-Seq_HPC-7_Human1.92386397
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89863280
23DROSHA_22980978_ChIP-Seq_HELA_Human1.89321568
24* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86928669
25* UTX_26944678_Chip-Seq_JUKART_Human1.86350224
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.83268541
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81597007
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78747991
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75787586
30* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.72970206
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70932346
32* MAF_26560356_Chip-Seq_TH1_Human1.69738345
33* KDM2B_26808549_Chip-Seq_K562_Human1.67701098
34AR_21572438_ChIP-Seq_LNCaP_Human1.64729376
35* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64701221
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.64324392
37* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58642841
38* MYB_26560356_Chip-Seq_TH1_Human1.58373973
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55421579
40* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54244601
41AR_21909140_ChIP-Seq_LNCAP_Human1.52554215
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50734135
43* MYB_26560356_Chip-Seq_TH2_Human1.50603272
44* ISL1_27105846_Chip-Seq_CPCs_Mouse1.49806528
45* KDM5A_27292631_Chip-Seq_BREAST_Human1.45982657
46* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45849288
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45802560
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44754546
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44754546
50* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42936640
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42238755
52PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41739632
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40407149
54VDR_24763502_ChIP-Seq_THP-1_Human1.38860224
55* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38183457
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37932839
57XRN2_22483619_ChIP-Seq_HELA_Human1.37604877
58* KDM2B_26808549_Chip-Seq_JURKAT_Human1.37375709
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35890739
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33722239
61* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32259027
62SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31811682
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30425058
64* ELK3_25401928_ChIP-Seq_HUVEC_Human1.29712372
65* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27882350
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24383116
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23655969
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22473484
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.21348794
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20608615
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17833772
72* MAF_26560356_Chip-Seq_TH2_Human1.16769492
73* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16411371
74* NCOR1_26117541_ChIP-Seq_K562_Human1.16141160
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16102424
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14944238
77* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14578441
78* CREB1_26743006_Chip-Seq_LNCaP_Human1.13247823
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11565529
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11515132
81EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10811709
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10506371
83* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10414722
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10311577
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.10075016
86* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09866159
87* RUNX1_22412390_ChIP-Seq_EML_Mouse1.09576634
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08904045
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08307949
90RUNX_20019798_ChIP-Seq_JUKART_Human1.07573617
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06908571
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05625519
93* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04672633
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04491291
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03897168
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.03598212
97* FOXP3_21729870_ChIP-Seq_TREG_Human1.03240407
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03026686
99* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02428310
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01451103
101* CHD1_26751641_Chip-Seq_LNCaP_Human1.00742542
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00504502
103SPI1_23547873_ChIP-Seq_NB4_Human0.99829721
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99585115
105POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97883280
106* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97879807
107* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97054576
108KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96890982
109KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96890982
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96890982
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96296282
112MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95544200
113TTF2_22483619_ChIP-Seq_HELA_Human0.93559629
114NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92252719
115RNF2_27304074_Chip-Seq_ESCs_Mouse0.92031811
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91813433
117TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91719345
118* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91637719
119* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90147073
120* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89728549
121* RUNX1_27514584_Chip-Seq_MCF-7_Human0.88942353
122* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88661173
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88566910
124* GATA1_19941826_ChIP-Seq_K562_Human0.87306039
125* GATA1_19941827_ChIP-Seq_MEL_Mouse0.86803752
126* SPI1_23127762_ChIP-Seq_K562_Human0.86480995
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86432754
128GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85496169
129VDR_23849224_ChIP-Seq_CD4+_Human0.85147757
130GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84835974
131WDR5_24793694_ChIP-Seq_LNCAP_Human0.83821128
132* RARB_27405468_Chip-Seq_BRAIN_Mouse0.83019650
133CBX2_27304074_Chip-Seq_ESCs_Mouse0.82343667
134* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81769080
135IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81389548
136* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79987274
137LXR_22292898_ChIP-Seq_THP-1_Human0.79805702
138* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79093666
139WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78871316

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.13509916
2MP0008057_abnormal_DNA_replication3.10632227
3MP0003693_abnormal_embryo_hatching3.08743707
4MP0010094_abnormal_chromosome_stability3.06333346
5MP0002396_abnormal_hematopoietic_system2.86941661
6MP0003077_abnormal_cell_cycle2.86303144
7MP0002009_preneoplasia2.86298344
8MP0005076_abnormal_cell_differentiation2.53003667
9MP0004957_abnormal_blastocyst_morpholog2.42213257
10MP0005409_darkened_coat_color2.21722691
11MP0009278_abnormal_bone_marrow2.20643233
12MP0003763_abnormal_thymus_physiology2.13000308
13MP0010352_gastrointestinal_tract_polyps2.08748350
14MP0004381_abnormal_hair_follicle2.08723813
15MP0008007_abnormal_cellular_replicative2.07730022
16MP0000350_abnormal_cell_proliferation2.00378996
17* MP0004808_abnormal_hematopoietic_stem1.99702380
18MP0008058_abnormal_DNA_repair1.95919518
19MP0008877_abnormal_DNA_methylation1.94208586
20MP0003121_genomic_imprinting1.94143692
21MP0002249_abnormal_larynx_morphology1.94098828
22MP0003787_abnormal_imprinting1.86419131
23* MP0001730_embryonic_growth_arrest1.84172388
24MP0005380_embryogenesis_phenotype1.84085109
25MP0001672_abnormal_embryogenesis/_devel1.84085109
26MP0000703_abnormal_thymus_morphology1.82572175
27MP0003984_embryonic_growth_retardation1.78357188
28MP0002088_abnormal_embryonic_growth/wei1.75886790
29* MP0002084_abnormal_developmental_patter1.67544287
30MP0003123_paternal_imprinting1.67122155
31* MP0002085_abnormal_embryonic_tissue1.64371456
32MP0002398_abnormal_bone_marrow1.63631615
33MP0001697_abnormal_embryo_size1.62581718
34MP0004197_abnormal_fetal_growth/weight/1.62079621
35MP0010307_abnormal_tumor_latency1.60743269
36MP0002086_abnormal_extraembryonic_tissu1.57618802
37MP0003890_abnormal_embryonic-extraembry1.56171744
38MP0003567_abnormal_fetal_cardiomyocyte1.54020093
39MP0003938_abnormal_ear_development1.46095194
40MP0000490_abnormal_crypts_of1.42309609
41MP0002653_abnormal_ependyma_morphology1.42001016
42MP0010030_abnormal_orbit_morphology1.40077491
43MP0006292_abnormal_olfactory_placode1.39368565
44MP0000778_abnormal_nervous_system1.37049057
45* MP0002080_prenatal_lethality1.33365711
46MP0001849_ear_inflammation1.31242159
47MP0002722_abnormal_immune_system1.30782164
48MP0009672_abnormal_birth_weight1.28302524
49MP0000569_abnormal_digit_pigmentation1.27273306
50MP0000631_abnormal_neuroendocrine_gland1.26050768
51MP0001293_anophthalmia1.25815553
52MP0005310_abnormal_salivary_gland1.24967837
53MP0008995_early_reproductive_senescence1.24632740
54MP0001800_abnormal_humoral_immune1.24481214
55MP0009703_decreased_birth_body1.23266319
56MP0008961_abnormal_basal_metabolism1.22163904
57MP0000689_abnormal_spleen_morphology1.21060502
58MP0009333_abnormal_splenocyte_physiolog1.19744348
59MP0000733_abnormal_muscle_development1.18764338
60* MP0005397_hematopoietic_system_phenotyp1.18603108
61* MP0001545_abnormal_hematopoietic_system1.18603108
62MP0000313_abnormal_cell_death1.18579308
63MP0002925_abnormal_cardiovascular_devel1.18068185
64MP0004185_abnormal_adipocyte_glucose1.16993340
65MP0002019_abnormal_tumor_incidence1.15448302
66MP0000716_abnormal_immune_system1.14971572
67MP0003935_abnormal_craniofacial_develop1.14500034
68MP0005645_abnormal_hypothalamus_physiol1.14195717
69MP0000428_abnormal_craniofacial_morphol1.13995788
70MP0003303_peritoneal_inflammation1.13440635
71MP0008932_abnormal_embryonic_tissue1.12479033
72MP0002166_altered_tumor_susceptibility1.11591137
73MP0003119_abnormal_digestive_system1.11092175
74MP0002089_abnormal_postnatal_growth/wei1.06532848
75MP0003300_gastrointestinal_ulcer1.06528733
76MP0003705_abnormal_hypodermis_morpholog1.06189297
77MP0003942_abnormal_urinary_system1.05469527
78MP0002429_abnormal_blood_cell1.05464606
79MP0000537_abnormal_urethra_morphology1.03884755
80MP0004264_abnormal_extraembryonic_tissu1.03520371
81MP0009053_abnormal_anal_canal1.02198648
82MP0003115_abnormal_respiratory_system1.01090641
83MP0005671_abnormal_response_to0.99625545
84MP0001915_intracranial_hemorrhage0.98695595
85MP0002092_abnormal_eye_morphology0.97384409
86MP0002420_abnormal_adaptive_immunity0.95460360
87MP0003283_abnormal_digestive_organ0.93556388
88MP0001819_abnormal_immune_cell0.93004382
89MP0000432_abnormal_head_morphology0.92365361
90MP0002152_abnormal_brain_morphology0.91034251
91MP0002452_abnormal_antigen_presenting0.90643743
92MP0001346_abnormal_lacrimal_gland0.90264016
93MP0002006_tumorigenesis0.90258723
94* MP0002081_perinatal_lethality0.88222378
95MP0003937_abnormal_limbs/digits/tail_de0.87727165
96MP0003943_abnormal_hepatobiliary_system0.87597397
97MP0005220_abnormal_exocrine_pancreas0.87444579
98MP0000685_abnormal_immune_system0.85794754
99MP0002405_respiratory_system_inflammati0.85633227
100MP0001188_hyperpigmentation0.85627555
101MP0001286_abnormal_eye_development0.84623371
102MP0002932_abnormal_joint_morphology0.84435348
103MP0003861_abnormal_nervous_system0.84184190
104MP0008789_abnormal_olfactory_epithelium0.83594931
105MP0000266_abnormal_heart_morphology0.83379423
106MP0003566_abnormal_cell_adhesion0.82177207
107MP0001790_abnormal_immune_system0.81500047
108MP0005387_immune_system_phenotype0.81500047
109MP0001784_abnormal_fluid_regulation0.80874629
110MP0005174_abnormal_tail_pigmentation0.80520594
111MP0010630_abnormal_cardiac_muscle0.79047765
112MP0000566_synostosis0.78590498
113MP0002723_abnormal_immune_serum0.78216920
114MP0010770_preweaning_lethality0.74240137
115MP0002082_postnatal_lethality0.74240137
116MP0004133_heterotaxia0.74113042
117MP0002114_abnormal_axial_skeleton0.74047882
118MP0002116_abnormal_craniofacial_bone0.74039853
119MP0002697_abnormal_eye_size0.73582751
120MP0003948_abnormal_gas_homeostasis0.73385785
121MP0003122_maternal_imprinting0.73182148
122MP0000470_abnormal_stomach_morphology0.72959437
123MP0008770_decreased_survivor_rate0.72453914
124MP0002928_abnormal_bile_duct0.72225045
125MP0003786_premature_aging0.71603970
126MP0005499_abnormal_olfactory_system0.71514468
127MP0005394_taste/olfaction_phenotype0.71514468
128MP0001873_stomach_inflammation0.71307253
129MP0002111_abnormal_tail_morphology0.70940545

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.74885071
2Genetic anticipation (HP:0003743)3.49995914
3Short 4th metacarpal (HP:0010044)3.49150227
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.49150227
5Volvulus (HP:0002580)3.15264749
6* Long eyelashes (HP:0000527)3.05708137
7Obstructive sleep apnea (HP:0002870)2.99616019
8Ectopic kidney (HP:0000086)2.83181542
9Hyperacusis (HP:0010780)2.77275481
10Trigonocephaly (HP:0000243)2.72264948
11Increased nuchal translucency (HP:0010880)2.72209930
12Urethral obstruction (HP:0000796)2.66417996
13Prominent nose (HP:0000448)2.59357157
14Medulloblastoma (HP:0002885)2.54767004
15Abnormal number of incisors (HP:0011064)2.53736013
16Ependymoma (HP:0002888)2.52419181
17Abnormality of the aortic arch (HP:0012303)2.49937622
18Broad face (HP:0000283)2.49603879
19Chromsome breakage (HP:0040012)2.46892960
20Anal stenosis (HP:0002025)2.46583185
21Hepatoblastoma (HP:0002884)2.42423352
22Abnormality of the distal phalanx of the thumb (HP:0009617)2.41274108
23Abnormality of the 4th metacarpal (HP:0010012)2.38818121
24Supernumerary ribs (HP:0005815)2.37339466
25Abnormal hair whorl (HP:0010721)2.30646727
26Proximal placement of thumb (HP:0009623)2.29252668
27Deep palmar crease (HP:0006191)2.28122872
28Deviation of the thumb (HP:0009603)2.27914051
29Acute lymphatic leukemia (HP:0006721)2.26628542
30Neoplasm of the oral cavity (HP:0100649)2.25508430
31Skin tags (HP:0010609)2.23280409
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23220765
33Neonatal hypoglycemia (HP:0001998)2.22534735
34Lip pit (HP:0100267)2.20782867
35Supernumerary bones of the axial skeleton (HP:0009144)2.19265881
36Renal duplication (HP:0000075)2.19258372
37T lymphocytopenia (HP:0005403)2.18867239
38Narrow palate (HP:0000189)2.14331718
39Syringomyelia (HP:0003396)2.12062673
40Spinal cord lesions (HP:0100561)2.12062673
41Broad thumb (HP:0011304)2.11828530
42Protruding tongue (HP:0010808)2.11522833
43Intestinal fistula (HP:0100819)2.10994316
44Heterotopia (HP:0002282)2.10527187
45Abnormality of the parietal bone (HP:0002696)2.10515444
46Macroorchidism (HP:0000053)2.09157821
47Acute myeloid leukemia (HP:0004808)2.09035833
48Broad palm (HP:0001169)2.08488726
49Tracheomalacia (HP:0002779)2.08068140
50Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.07086454
51Broad finger (HP:0001500)2.06684177
52Basal cell carcinoma (HP:0002671)2.06032150
53Abnormality of incisor morphology (HP:0011063)2.05978760
54Rib fusion (HP:0000902)2.05383612
55Bronchomalacia (HP:0002780)2.04728754
56Depressed nasal tip (HP:0000437)2.02816612
57Panhypogammaglobulinemia (HP:0003139)2.01796637
58Recurrent viral infections (HP:0004429)2.01440138
59Colon cancer (HP:0003003)1.99644850
60Sparse lateral eyebrow (HP:0005338)1.99022769
61Abnormality of the incisor (HP:0000676)1.97157950
62Vertebral arch anomaly (HP:0008438)1.97041511
63Homocystinuria (HP:0002156)1.96779946
64Abnormality of homocysteine metabolism (HP:0010919)1.96779946
65Abnormality of the astrocytes (HP:0100707)1.96080642
66Astrocytoma (HP:0009592)1.96080642
67Disproportionate tall stature (HP:0001519)1.95823685
68Preauricular skin tag (HP:0000384)1.95811327
69Abnormality of T cell number (HP:0011839)1.93569506
70Obsessive-compulsive behavior (HP:0000722)1.92919154
71Dysmetric saccades (HP:0000641)1.92763857
72Skull defect (HP:0001362)1.92469326
73Hypoplastic ischia (HP:0003175)1.92069354
74* Patellar aplasia (HP:0006443)1.91079872
75Hypoplastic iliac wings (HP:0002866)1.90982050
76Myelodysplasia (HP:0002863)1.90400440
77Neoplasm of the adrenal cortex (HP:0100641)1.89058149
78Facial hemangioma (HP:0000329)1.88539882
79Gastrointestinal carcinoma (HP:0002672)1.87342653
80Malignant gastrointestinal tract tumors (HP:0006749)1.87342653
81Laryngomalacia (HP:0001601)1.87176157
82Selective tooth agenesis (HP:0001592)1.87069069
83Hypoplasia of the maxilla (HP:0000327)1.86575111
84Aqueductal stenosis (HP:0002410)1.86294839
85Deep philtrum (HP:0002002)1.85716605
86Elfin facies (HP:0004428)1.81794852
87Shallow orbits (HP:0000586)1.81639632
88Bicuspid aortic valve (HP:0001647)1.81198054
89Overlapping toe (HP:0001845)1.79099177
90* Aplasia/Hypoplasia of the patella (HP:0006498)1.78585010
91Truncal obesity (HP:0001956)1.78483713
92Limited elbow extension (HP:0001377)1.77710278
93Broad phalanx (HP:0006009)1.77681991
94Impulsivity (HP:0100710)1.77561434
95Partial agenesis of the corpus callosum (HP:0001338)1.76680289
96Abnormality of the labia minora (HP:0012880)1.76556892
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.76410010
98Long palpebral fissure (HP:0000637)1.75599521
99IgM deficiency (HP:0002850)1.75466351
100Renovascular hypertension (HP:0100817)1.75208802
101Sporadic (HP:0003745)1.75007507
102Broad phalanges of the hand (HP:0009768)1.74889811
103Neoplasm of striated muscle (HP:0009728)1.74678928
104Abnormality of the carotid arteries (HP:0005344)1.74357426
105Atresia of the external auditory canal (HP:0000413)1.74084138
106Abnormality of chromosome stability (HP:0003220)1.74037198
107* Cutis marmorata (HP:0000965)1.73936222
108Abnormal delayed hypersensitivity skin test (HP:0002963)1.73869224
109Midline defect of the nose (HP:0004122)1.73460654
110Cafe-au-lait spot (HP:0000957)1.72931484
111Tented upper lip vermilion (HP:0010804)1.72754554
112Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72064690
113Cellulitis (HP:0100658)1.71774796
114Thyroiditis (HP:0100646)1.71133490
115Low anterior hairline (HP:0000294)1.70997627
116Oligodactyly (HP:0012165)1.70305345
117Broad hallux (HP:0010055)1.69472120
118Meckel diverticulum (HP:0002245)1.69335280
119Aplasia/Hypoplasia of the uvula (HP:0010293)1.68669917
120Synophrys (HP:0000664)1.68209202
12111 pairs of ribs (HP:0000878)1.68141721
122Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67816356
123Dislocated radial head (HP:0003083)1.67769218
124Chin dimple (HP:0010751)1.67759711
125Sandal gap (HP:0001852)1.67729364
126Glioma (HP:0009733)1.67714284
127Shawl scrotum (HP:0000049)1.67024296
128Abnormality of the phalanges of the hallux (HP:0010057)1.66585381
129Agammaglobulinemia (HP:0004432)1.65934050
130Abnormality of the ischium (HP:0003174)1.65529767
131Persistence of primary teeth (HP:0006335)1.65445403
132Abnormality of the columella (HP:0009929)1.63072092
133Overriding aorta (HP:0002623)1.63007386
134Abnormality of chromosome segregation (HP:0002916)1.62550679
135Abnormality of the pubic bones (HP:0003172)1.62414713
136Abnormality of the nasal septum (HP:0000419)1.61957300
137Short phalanx of the thumb (HP:0009660)1.61795239
138Uterine leiomyosarcoma (HP:0002891)1.61496412
139Leiomyosarcoma (HP:0100243)1.61496412
140Abnormality of B cell number (HP:0010975)1.61467581
141B lymphocytopenia (HP:0010976)1.61467581
142High anterior hairline (HP:0009890)1.60912521
143Abnormality of the radial head (HP:0003995)1.60875236
144Metaphyseal cupping (HP:0003021)1.60580470
145Abnormality of the ileum (HP:0001549)1.60031998
146Broad long bones (HP:0005622)1.59577699
147Germ cell neoplasia (HP:0100728)1.59380604
148Progressive cerebellar ataxia (HP:0002073)1.59066623
149Abnormality of the humeroradial joint (HP:0100744)1.58255644
150Tapered finger (HP:0001182)1.56730710
151Deeply set eye (HP:0000490)1.56521487
152Diastasis recti (HP:0001540)1.55957448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.09245918
2EEF2K3.54871114
3BRD43.34674849
4MAP3K103.21665601
5CDC73.16806466
6MAP4K12.86127722
7SMG12.52253837
8NEK22.45639755
9STK101.98937388
10LATS11.97118614
11FGFR21.93765676
12PRPF4B1.73995473
13CDK41.67749127
14RIPK41.65576554
15MKNK21.62532213
16CAMK1D1.56687095
17MKNK11.54881745
18CAMK1G1.53295263
19CDK71.52679019
20SIK21.51504617
21PKN21.45401291
22FGFR41.44697176
23TNIK1.43324597
24MTOR1.40374803
25WNK11.40345440
26ATR1.39018130
27ALK1.35489302
28RPS6KB21.33566277
29TRIB31.31561817
30CHEK11.29206793
31ICK1.28806597
32TNK21.28293585
33TTK1.24437694
34CDK61.23069324
35CDK91.22024091
36STK41.19336508
37TAOK11.17544233
38TSSK61.17262677
39STK31.15914131
40SGK21.15830162
41SRPK11.14340205
42DMPK1.13997817
43CLK11.12085930
44RPS6KA41.07707960
45CHEK21.07168805
46PIM11.02777943
47WEE10.99768292
48GRK60.98894019
49TXK0.98758554
50BTK0.98134044
51ATM0.97506038
52JAK30.95415221
53* CDK20.95410989
54FGFR30.92004029
55NLK0.89611312
56CHUK0.87455173
57MELK0.87177225
58PASK0.85253980
59SGK2230.83717223
60SGK4940.83717223
61PLK10.83689520
62MAP3K80.83605431
63ZAP700.83226707
64AURKB0.80651122
65ITK0.76070611
66PRKD20.75686650
67AKT30.74772496
68HIPK20.72186350
69PLK40.70986492
70DYRK30.69356427
71CSF1R0.69350739
72MARK20.69109360
73PTK60.68614126
74CDK10.68144949
75STK110.67803299
76TGFBR10.67674927
77HCK0.67437266
78TAF10.65950213
79PDGFRB0.65227071
80PRKCH0.64535555
81SGK30.63532507
82PAK40.63484813
83RPS6KL10.62919745
84RPS6KC10.62919745
85CDK30.61781106
86RPS6KA60.61677755
87MAPK140.61626591
88TYRO30.59313793
89MAP3K70.59294193
90YES10.59255004
91LRRK20.57036599
92SIK30.56830099
93PLK30.55381485
94RPS6KA20.54719343
95FES0.54122358
96NTRK20.52897526
97RET0.51946396
98FGFR10.51938823
99TGFBR20.51222238
100BUB10.50813770
101MAP2K20.50209985
102LATS20.49950142
103MAPK70.49946691
104MARK30.49503613
105SIK10.49378537
106MAPK10.48933726
107CDK80.48252872
108LCK0.47807412
109* GSK3B0.46902792
110CSNK1D0.46644394
111CAMKK10.45861671
112TAOK30.44276865
113MAPK110.44069317
114MAP3K130.43734675
115PDGFRA0.43585305
116PRKDC0.43272093
117CAMK40.43256158
118AKT10.43214881
119PNCK0.43098383
120MAP2K30.42121465
121SGK10.42090627
122SYK0.42020183
123ERBB20.41626328
124UHMK10.41350152
125PRKAA10.41106423
126CSNK1A1L0.40701881
127PAK20.39862702
128RPS6KA10.39780143
129CAMK10.39231113
130TTN0.39166121
131NUAK10.37821231
132CDC42BPA0.37119991
133KSR20.37048895
134ERN10.36758603
135MAPK100.36133694
136* MAPK80.34694474

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030402.30229959
2DNA replication_Homo sapiens_hsa030302.28229279
3Cell cycle_Homo sapiens_hsa041102.22144115
4RNA transport_Homo sapiens_hsa030132.09507307
5mRNA surveillance pathway_Homo sapiens_hsa030152.05697083
6Primary immunodeficiency_Homo sapiens_hsa053402.03541960
7Mismatch repair_Homo sapiens_hsa034302.00960170
8Base excision repair_Homo sapiens_hsa034101.85175279
9Notch signaling pathway_Homo sapiens_hsa043301.80887724
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74254709
11Non-homologous end-joining_Homo sapiens_hsa034501.62913313
12Chronic myeloid leukemia_Homo sapiens_hsa052201.62635470
13B cell receptor signaling pathway_Homo sapiens_hsa046621.54814531
14Lysine degradation_Homo sapiens_hsa003101.54239065
15MicroRNAs in cancer_Homo sapiens_hsa052061.51716340
16Herpes simplex infection_Homo sapiens_hsa051681.45359391
17Fanconi anemia pathway_Homo sapiens_hsa034601.43262694
18Colorectal cancer_Homo sapiens_hsa052101.42085601
19Homologous recombination_Homo sapiens_hsa034401.39309853
20RNA degradation_Homo sapiens_hsa030181.39058617
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36263297
22Acute myeloid leukemia_Homo sapiens_hsa052211.34969818
23T cell receptor signaling pathway_Homo sapiens_hsa046601.34647865
24Basal cell carcinoma_Homo sapiens_hsa052171.34527488
25HTLV-I infection_Homo sapiens_hsa051661.32084406
26Adherens junction_Homo sapiens_hsa045201.29864748
27Thyroid cancer_Homo sapiens_hsa052161.22657853
28Endometrial cancer_Homo sapiens_hsa052131.22150506
29Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20785603
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20633184
31Non-small cell lung cancer_Homo sapiens_hsa052231.18237553
32Small cell lung cancer_Homo sapiens_hsa052221.17944799
33mTOR signaling pathway_Homo sapiens_hsa041501.17594526
34p53 signaling pathway_Homo sapiens_hsa041151.17025448
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16713890
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16130970
37Antigen processing and presentation_Homo sapiens_hsa046121.15329152
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.15128305
39Viral myocarditis_Homo sapiens_hsa054161.14417003
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13983973
41Pancreatic cancer_Homo sapiens_hsa052121.10362819
42Type II diabetes mellitus_Homo sapiens_hsa049301.10325169
43Nucleotide excision repair_Homo sapiens_hsa034201.09834178
44Epstein-Barr virus infection_Homo sapiens_hsa051691.09821582
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09292065
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.08876722
47Viral carcinogenesis_Homo sapiens_hsa052031.08592842
48Estrogen signaling pathway_Homo sapiens_hsa049151.07303233
49Measles_Homo sapiens_hsa051621.06688149
50Hepatitis B_Homo sapiens_hsa051611.06373019
51Prostate cancer_Homo sapiens_hsa052151.05206444
52Basal transcription factors_Homo sapiens_hsa030221.04414759
53Neurotrophin signaling pathway_Homo sapiens_hsa047221.01937518
54Hippo signaling pathway_Homo sapiens_hsa043900.97006344
55One carbon pool by folate_Homo sapiens_hsa006700.95387336
56Melanogenesis_Homo sapiens_hsa049160.95313428
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94760541
58Osteoclast differentiation_Homo sapiens_hsa043800.90957955
59Hematopoietic cell lineage_Homo sapiens_hsa046400.90065173
60Wnt signaling pathway_Homo sapiens_hsa043100.89136751
61FoxO signaling pathway_Homo sapiens_hsa040680.88683701
62Pathways in cancer_Homo sapiens_hsa052000.88497417
63RNA polymerase_Homo sapiens_hsa030200.87571459
64Long-term potentiation_Homo sapiens_hsa047200.87453117
65TGF-beta signaling pathway_Homo sapiens_hsa043500.86848850
66Cholinergic synapse_Homo sapiens_hsa047250.86709037
67Oocyte meiosis_Homo sapiens_hsa041140.85887084
68Leishmaniasis_Homo sapiens_hsa051400.85654517
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85147100
70Renal cell carcinoma_Homo sapiens_hsa052110.84970072
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84511634
72Influenza A_Homo sapiens_hsa051640.84165068
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.84037935
74Hedgehog signaling pathway_Homo sapiens_hsa043400.83329481
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.82780991
76Proteoglycans in cancer_Homo sapiens_hsa052050.82506209
77GnRH signaling pathway_Homo sapiens_hsa049120.82335938
78Dorso-ventral axis formation_Homo sapiens_hsa043200.82138309
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78711554
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.78693159
81Toxoplasmosis_Homo sapiens_hsa051450.77301021
82Prolactin signaling pathway_Homo sapiens_hsa049170.75769266
83Apoptosis_Homo sapiens_hsa042100.74351894
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72949450
85Platelet activation_Homo sapiens_hsa046110.72794162
86Axon guidance_Homo sapiens_hsa043600.71773318
87Insulin signaling pathway_Homo sapiens_hsa049100.71596363
88Glioma_Homo sapiens_hsa052140.71182444
89Chemokine signaling pathway_Homo sapiens_hsa040620.71156862
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70984751
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70968217
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67830261
93Shigellosis_Homo sapiens_hsa051310.66917458
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66787186
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66653194
96VEGF signaling pathway_Homo sapiens_hsa043700.65276154
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65212407
98Long-term depression_Homo sapiens_hsa047300.63978244
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63875193
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62615282
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61840124
102Insulin resistance_Homo sapiens_hsa049310.61636239
103MAPK signaling pathway_Homo sapiens_hsa040100.60681115
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60118668
105AMPK signaling pathway_Homo sapiens_hsa041520.58892772
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.58124604
107ErbB signaling pathway_Homo sapiens_hsa040120.57936584
108Melanoma_Homo sapiens_hsa052180.57107119
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56514719
110Bladder cancer_Homo sapiens_hsa052190.56004796
111Hepatitis C_Homo sapiens_hsa051600.55976876
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55612419
113HIF-1 signaling pathway_Homo sapiens_hsa040660.54032639
114TNF signaling pathway_Homo sapiens_hsa046680.53936953
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53703821
116Focal adhesion_Homo sapiens_hsa045100.53632946
117Ras signaling pathway_Homo sapiens_hsa040140.53278641
118Choline metabolism in cancer_Homo sapiens_hsa052310.52271608
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51426078
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51413875
121Rap1 signaling pathway_Homo sapiens_hsa040150.51020241
122Pyrimidine metabolism_Homo sapiens_hsa002400.50780308
123cAMP signaling pathway_Homo sapiens_hsa040240.50741067
124Glutamatergic synapse_Homo sapiens_hsa047240.50674150
125Inositol phosphate metabolism_Homo sapiens_hsa005620.49348646

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