ARHGEF39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.07664188
2attachment of spindle microtubules to kinetochore (GO:0008608)5.92801837
3mitotic metaphase plate congression (GO:0007080)5.89481615
4mitotic chromosome condensation (GO:0007076)5.60456154
5protein localization to chromosome, centromeric region (GO:0071459)5.58676814
6mitotic sister chromatid segregation (GO:0000070)5.44732639
7CENP-A containing nucleosome assembly (GO:0034080)5.33245196
8kinetochore organization (GO:0051383)5.31912059
9metaphase plate congression (GO:0051310)5.30307386
10chromatin remodeling at centromere (GO:0031055)5.10234766
11establishment of chromosome localization (GO:0051303)4.99166075
12kinetochore assembly (GO:0051382)4.89094641
13sister chromatid segregation (GO:0000819)4.83999090
14regulation of spindle organization (GO:0090224)4.80478096
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.77721390
16DNA replication-independent nucleosome organization (GO:0034724)4.76437037
17DNA replication-independent nucleosome assembly (GO:0006336)4.76437037
18meiotic chromosome segregation (GO:0045132)4.72685737
19DNA strand elongation involved in DNA replication (GO:0006271)4.59407234
20telomere maintenance via semi-conservative replication (GO:0032201)4.51282449
21DNA strand elongation (GO:0022616)4.38185980
22histone exchange (GO:0043486)4.31507853
23DNA replication initiation (GO:0006270)4.22281406
24telomere maintenance via recombination (GO:0000722)4.16568931
25mitotic nuclear envelope disassembly (GO:0007077)4.16222291
26protein localization to chromosome (GO:0034502)4.15959163
27spindle checkpoint (GO:0031577)4.14078056
28chromosome segregation (GO:0007059)4.13617384
29DNA replication checkpoint (GO:0000076)4.07153762
30regulation of mitotic spindle organization (GO:0060236)4.03494164
31negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.01856063
32mitotic recombination (GO:0006312)4.00023489
33regulation of chromosome segregation (GO:0051983)3.95936904
34nuclear envelope disassembly (GO:0051081)3.84750339
35membrane disassembly (GO:0030397)3.84750339
36negative regulation of chromosome segregation (GO:0051985)3.84398637
37spindle assembly checkpoint (GO:0071173)3.83188059
38negative regulation of mitotic sister chromatid separation (GO:2000816)3.80105989
39negative regulation of mitotic sister chromatid segregation (GO:0033048)3.80105989
40negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.80105989
41negative regulation of sister chromatid segregation (GO:0033046)3.80105989
42regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.79861592
43positive regulation of chromosome segregation (GO:0051984)3.79224229
44DNA deamination (GO:0045006)3.75801794
45telomere maintenance via telomere lengthening (GO:0010833)3.75557436
46chromatin assembly or disassembly (GO:0006333)3.73831667
47mitotic spindle assembly checkpoint (GO:0007094)3.72645482
48regulation of sister chromatid cohesion (GO:0007063)3.69050019
49DNA unwinding involved in DNA replication (GO:0006268)3.67298269
50mitotic spindle checkpoint (GO:0071174)3.66372824
51regulation of exit from mitosis (GO:0007096)3.64744311
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.63419347
53ribosomal small subunit assembly (GO:0000028)3.62962752
54regulation of mitotic metaphase/anaphase transition (GO:0030071)3.62658175
55protein K6-linked ubiquitination (GO:0085020)3.58544020
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.57122543
57regulation of sister chromatid segregation (GO:0033045)3.52098977
58regulation of mitotic sister chromatid separation (GO:0010965)3.52098977
59regulation of mitotic sister chromatid segregation (GO:0033047)3.52098977
60DNA ligation (GO:0006266)3.51511563
61nucleotide-excision repair, DNA gap filling (GO:0006297)3.48226470
62positive regulation of mitotic sister chromatid separation (GO:1901970)3.47963721
63positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.47963721
64positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.47963721
65DNA replication-dependent nucleosome assembly (GO:0006335)3.39434980
66DNA replication-dependent nucleosome organization (GO:0034723)3.39434980
67chromosome condensation (GO:0030261)3.37817856
68replication fork processing (GO:0031297)3.35210351
69regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.26547367
70regulation of mitotic spindle checkpoint (GO:1903504)3.26547367
71protein complex biogenesis (GO:0070271)3.25294541
72mitochondrial respiratory chain complex assembly (GO:0033108)3.24646625
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23739757
74DNA strand renaturation (GO:0000733)3.20856374
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19547890
76mitochondrial respiratory chain complex I assembly (GO:0032981)3.19547890
77NADH dehydrogenase complex assembly (GO:0010257)3.19547890
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17001034
79microtubule polymerization or depolymerization (GO:0031109)3.15669744
80pseudouridine synthesis (GO:0001522)3.15349100
81regulation of double-strand break repair via homologous recombination (GO:0010569)3.14357332
82ATP-dependent chromatin remodeling (GO:0043044)3.13677735
83mitotic cell cycle (GO:0000278)3.13443547
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.09036526
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09036526
86negative regulation of DNA-dependent DNA replication (GO:2000104)3.08864295
87maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08776725
88negative regulation of mitosis (GO:0045839)3.08092815
89regulation of telomere maintenance via telomerase (GO:0032210)3.08002925
90nuclear envelope organization (GO:0006998)3.06089807
91rRNA modification (GO:0000154)3.04400975
92meiotic cell cycle (GO:0051321)3.03659982
93recombinational repair (GO:0000725)3.02802177
94mitotic sister chromatid cohesion (GO:0007064)2.99950171
95DNA topological change (GO:0006265)2.99582160
96DNA packaging (GO:0006323)2.99241047
97maturation of 5.8S rRNA (GO:0000460)2.99083895
98pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98680422
99DNA damage response, signal transduction resulting in transcription (GO:0042772)2.98399868
100DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.98375494
101histone-serine phosphorylation (GO:0035404)2.97007889
102double-strand break repair via homologous recombination (GO:0000724)2.96266618
103regulation of centrosome cycle (GO:0046605)2.95762085
104DNA double-strand break processing (GO:0000729)2.95562820
105microtubule depolymerization (GO:0007019)2.95102735
106mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94637447
107proteasome assembly (GO:0043248)2.93736553
108folic acid-containing compound biosynthetic process (GO:0009396)2.93678605
109telomere maintenance (GO:0000723)2.91135860
110mitotic nuclear division (GO:0007067)2.90677745
111negative regulation of cell division (GO:0051782)2.90261225
112negative regulation of DNA-templated transcription, elongation (GO:0032785)2.90253649
113negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.90253649
114telomere organization (GO:0032200)2.89305475
115mitochondrial RNA metabolic process (GO:0000959)2.88973292
116regulation of mitochondrial translation (GO:0070129)2.87538314
117chromosome organization (GO:0051276)2.87119684
118mismatch repair (GO:0006298)2.86829956
119resolution of meiotic recombination intermediates (GO:0000712)2.86761333
120protein-cofactor linkage (GO:0018065)2.85493222
121nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85228289
122regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85156117
123negative regulation of nuclear division (GO:0051784)2.84156198
124energy coupled proton transport, down electrochemical gradient (GO:0015985)2.83980273
125ATP synthesis coupled proton transport (GO:0015986)2.83980273
126base-excision repair, AP site formation (GO:0006285)2.83933074
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83014245
128reciprocal DNA recombination (GO:0035825)2.82535350
129reciprocal meiotic recombination (GO:0007131)2.82535350
130tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82478808
131RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82478808
132respiratory chain complex IV assembly (GO:0008535)2.80762903
133centriole replication (GO:0007099)2.80127720
134maturation of SSU-rRNA (GO:0030490)2.79582554
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.78857596
136regulation of centriole replication (GO:0046599)2.77187940
137DNA catabolic process, exonucleolytic (GO:0000738)2.74496487
138nucleobase biosynthetic process (GO:0046112)2.70998556
139negative regulation of telomere maintenance (GO:0032205)2.70677518
140regulation of spindle checkpoint (GO:0090231)2.69268283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.75788541
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.98959651
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.57549285
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.32816498
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.51838743
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21067793
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12822575
8AR_21909140_ChIP-Seq_LNCAP_Human2.81478483
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58895169
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.53881790
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.44210642
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44045086
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41231162
14ZNF274_21170338_ChIP-Seq_K562_Hela2.38217604
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36371713
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.33244879
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25876527
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25014192
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23295667
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21288338
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.19602320
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11733242
23XRN2_22483619_ChIP-Seq_HELA_Human2.05228798
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.02819565
25VDR_23849224_ChIP-Seq_CD4+_Human2.00657953
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97191047
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94431178
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92505625
29DCP1A_22483619_ChIP-Seq_HELA_Human1.84099675
30FOXP3_21729870_ChIP-Seq_TREG_Human1.83675390
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80194971
32GABP_19822575_ChIP-Seq_HepG2_Human1.76378669
33CIITA_25753668_ChIP-Seq_RAJI_Human1.76084777
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69514483
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65669164
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65294698
37MYC_22102868_ChIP-Seq_BL_Human1.64599447
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63325958
39TTF2_22483619_ChIP-Seq_HELA_Human1.62550562
40VDR_22108803_ChIP-Seq_LS180_Human1.59816819
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59634592
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56524145
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55915784
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55885709
45IRF1_19129219_ChIP-ChIP_H3396_Human1.55275095
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53297719
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.49596428
48VDR_21846776_ChIP-Seq_THP-1_Human1.49200498
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43695226
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41375959
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.39174596
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39160084
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39076091
54EWS_26573619_Chip-Seq_HEK293_Human1.37196317
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37000246
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36707931
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36029809
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35872336
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35413124
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34633261
61KDM5A_27292631_Chip-Seq_BREAST_Human1.32999288
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.31830000
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29993232
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.29383665
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.26076809
66ELK1_19687146_ChIP-ChIP_HELA_Human1.22425399
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22294046
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22278526
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21275177
70MYC_18940864_ChIP-ChIP_HL60_Human1.20953075
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19455515
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14550037
73SPI1_23547873_ChIP-Seq_NB4_Human1.14004781
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10943704
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10524737
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09479707
77FUS_26573619_Chip-Seq_HEK293_Human1.09418607
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05740659
79SCL_19346495_ChIP-Seq_HPC-7_Human1.05095580
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.04042556
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00228140
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99961805
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98623097
84TP53_22573176_ChIP-Seq_HFKS_Human0.95590965
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95444152
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95006314
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94656006
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94018881
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93647887
90NANOG_16153702_ChIP-ChIP_HESCs_Human0.92874018
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92380904
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90884186
93TFEB_21752829_ChIP-Seq_HELA_Human0.90541599
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90246808
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89801133
96NANOG_21062744_ChIP-ChIP_HESCs_Human0.89160307
97FOXP1_21924763_ChIP-Seq_HESCs_Human0.86954206
98GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86704506
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85395472
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84914282
101STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83693034
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83413275
103ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81999906
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81722257
105NOTCH1_21737748_ChIP-Seq_TLL_Human0.80278921
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79872497
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79801402
108RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.79702400
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79679270
110SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78455048
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78391080
112ERA_21632823_ChIP-Seq_H3396_Human0.78103412
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77680958
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77255773
115RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.77101766
116IGF1R_20145208_ChIP-Seq_DFB_Human0.76400136
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76109794
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75470097
119TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75388921
120PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.75329544
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.74787738
122RUNX1_22412390_ChIP-Seq_EML_Mouse0.74291255
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74264441
124UTX_26944678_Chip-Seq_JUKART_Human0.74044974
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.74043868
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73762967
127EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.73572172
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.69732486
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.66528058
130NANOG_20526341_ChIP-Seq_ESCs_Human0.65244957
131CTBP2_25329375_ChIP-Seq_LNCAP_Human0.63205050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.31617669
2MP0003111_abnormal_nucleus_morphology5.19004183
3MP0010094_abnormal_chromosome_stability5.04505846
4MP0003077_abnormal_cell_cycle4.51040441
5MP0004957_abnormal_blastocyst_morpholog4.32547859
6MP0008057_abnormal_DNA_replication3.35465787
7MP0002396_abnormal_hematopoietic_system3.05349570
8MP0003718_maternal_effect3.02395363
9MP0008007_abnormal_cellular_replicative2.94995832
10MP0008058_abnormal_DNA_repair2.85269801
11MP0008932_abnormal_embryonic_tissue2.53080043
12MP0008877_abnormal_DNA_methylation2.35578300
13MP0000490_abnormal_crypts_of2.29678906
14MP0000350_abnormal_cell_proliferation2.10719486
15MP0001730_embryonic_growth_arrest1.96632477
16MP0002234_abnormal_pharynx_morphology1.93785466
17MP0001529_abnormal_vocalization1.89625154
18MP0008789_abnormal_olfactory_epithelium1.85695431
19MP0002938_white_spotting1.84316845
20MP0003786_premature_aging1.80963445
21MP0002019_abnormal_tumor_incidence1.73628725
22MP0005397_hematopoietic_system_phenotyp1.73368344
23MP0001545_abnormal_hematopoietic_system1.73368344
24MP0005451_abnormal_body_composition1.71041744
25MP0010307_abnormal_tumor_latency1.70812459
26MP0003123_paternal_imprinting1.70573765
27MP0003136_yellow_coat_color1.65719157
28MP0004808_abnormal_hematopoietic_stem1.63233889
29MP0003890_abnormal_embryonic-extraembry1.63222515
30MP0004133_heterotaxia1.61505886
31MP0008995_early_reproductive_senescence1.56800744
32MP0003646_muscle_fatigue1.55035598
33MP0001293_anophthalmia1.54854277
34MP0000566_synostosis1.52618666
35MP0001697_abnormal_embryo_size1.50985397
36MP0001929_abnormal_gametogenesis1.48832458
37MP0005645_abnormal_hypothalamus_physiol1.48088512
38MP0001119_abnormal_female_reproductive1.47011460
39MP0003806_abnormal_nucleotide_metabolis1.46035499
40MP0005499_abnormal_olfactory_system1.44860657
41MP0005394_taste/olfaction_phenotype1.44860657
42MP0000313_abnormal_cell_death1.44303193
43MP0000049_abnormal_middle_ear1.44197083
44MP0002210_abnormal_sex_determination1.43757678
45MP0003763_abnormal_thymus_physiology1.42591062
46MP0003119_abnormal_digestive_system1.41738117
47MP0001672_abnormal_embryogenesis/_devel1.41382434
48MP0005380_embryogenesis_phenotype1.41382434
49MP0001986_abnormal_taste_sensitivity1.40455175
50MP0003878_abnormal_ear_physiology1.39600434
51MP0005377_hearing/vestibular/ear_phenot1.39600434
52MP0006072_abnormal_retinal_apoptosis1.39157208
53MP0002080_prenatal_lethality1.37507580
54MP0002102_abnormal_ear_morphology1.37452070
55MP0003656_abnormal_erythrocyte_physiolo1.37029396
56MP0002398_abnormal_bone_marrow1.34749319
57MP0002163_abnormal_gland_morphology1.34341668
58MP0002736_abnormal_nociception_after1.34046825
59MP0005423_abnormal_somatic_nervous1.33614706
60MP0001188_hyperpigmentation1.31433361
61MP0000653_abnormal_sex_gland1.31221351
62MP0009333_abnormal_splenocyte_physiolog1.31098451
63MP0001346_abnormal_lacrimal_gland1.29702212
64MP0005410_abnormal_fertilization1.29695478
65MP0002085_abnormal_embryonic_tissue1.28264269
66MP0006035_abnormal_mitochondrial_morpho1.27518542
67MP0003315_abnormal_perineum_morphology1.26982140
68MP0003698_abnormal_male_reproductive1.25725713
69MP0003699_abnormal_female_reproductive1.21023791
70MP0001145_abnormal_male_reproductive1.19393496
71MP0000689_abnormal_spleen_morphology1.19118489
72MP0002722_abnormal_immune_system1.19001154
73MP0003984_embryonic_growth_retardation1.18274568
74MP0000631_abnormal_neuroendocrine_gland1.16789245
75MP0000372_irregular_coat_pigmentation1.15986752
76MP0005551_abnormal_eye_electrophysiolog1.15751436
77MP0000703_abnormal_thymus_morphology1.14486835
78MP0002088_abnormal_embryonic_growth/wei1.13183488
79MP0001485_abnormal_pinna_reflex1.12643837
80MP0003195_calcinosis1.11684516
81MP0004264_abnormal_extraembryonic_tissu1.09610440
82MP0003938_abnormal_ear_development1.08920108
83MP0002086_abnormal_extraembryonic_tissu1.07852884
84MP0002160_abnormal_reproductive_system1.07071268
85MP0001968_abnormal_touch/_nociception1.07070553
86MP0005084_abnormal_gallbladder_morpholo1.04362681
87MP0000465_gastrointestinal_hemorrhage1.03955590
88MP0005253_abnormal_eye_physiology1.03449792
89MP0002429_abnormal_blood_cell1.02816216
90MP0002084_abnormal_developmental_patter1.01808881
91MP0001286_abnormal_eye_development1.01053397
92MP0003121_genomic_imprinting0.99064815
93MP0006054_spinal_hemorrhage0.98671469
94MP0009697_abnormal_copulation0.96879370
95MP0003567_abnormal_fetal_cardiomyocyte0.96354184
96MP0005395_other_phenotype0.96106736
97MP0006292_abnormal_olfactory_placode0.95275612
98MP0002653_abnormal_ependyma_morphology0.94810451
99MP0010352_gastrointestinal_tract_polyps0.94534951
100MP0000858_altered_metastatic_potential0.92151966
101MP0000716_abnormal_immune_system0.91677821
102MP0004147_increased_porphyrin_level0.91605279
103MP0002837_dystrophic_cardiac_calcinosis0.90848707
104MP0005646_abnormal_pituitary_gland0.89053109
105MP0001764_abnormal_homeostasis0.88527779
106MP0003186_abnormal_redox_activity0.88165170
107MP0004142_abnormal_muscle_tone0.87716260
108MP0009278_abnormal_bone_marrow0.87065625
109MP0005174_abnormal_tail_pigmentation0.85796270
110MP0008872_abnormal_physiological_respon0.85774948
111MP0001835_abnormal_antigen_presentation0.84927984
112MP0002095_abnormal_skin_pigmentation0.84081151
113MP0004742_abnormal_vestibular_system0.83529772
114MP0002132_abnormal_respiratory_system0.83009620
115MP0003787_abnormal_imprinting0.82832151
116MP0001919_abnormal_reproductive_system0.82265080
117MP0006036_abnormal_mitochondrial_physio0.82175368
118MP0008875_abnormal_xenobiotic_pharmacok0.79850159
119MP0002735_abnormal_chemical_nociception0.78519999
120MP0000427_abnormal_hair_cycle0.78499984
121MP0005391_vision/eye_phenotype0.77589199
122MP0005621_abnormal_cell_physiology0.77429438
123MP0002420_abnormal_adaptive_immunity0.76591013
124MP0002161_abnormal_fertility/fecundity0.76529613
125MP0001915_intracranial_hemorrhage0.76339628
126MP0005408_hypopigmentation0.76208871
127MP0005379_endocrine/exocrine_gland_phen0.75926363
128MP0000685_abnormal_immune_system0.75794646
129MP0005464_abnormal_platelet_physiology0.75557273
130MP0001819_abnormal_immune_cell0.75469739
131MP0002638_abnormal_pupillary_reflex0.74544248
132MP0001905_abnormal_dopamine_level0.73599568
133MP0009046_muscle_twitch0.73542916
134MP0005384_cellular_phenotype0.71510954
135MP0001800_abnormal_humoral_immune0.71404865
136MP0000026_abnormal_inner_ear0.70997323
137MP0002111_abnormal_tail_morphology0.70945565
138MP0001324_abnormal_eye_pigmentation0.70746656
139MP0002452_abnormal_antigen_presenting0.67153127
140MP0005076_abnormal_cell_differentiation0.66534287
141MP0005075_abnormal_melanosome_morpholog0.66153795
142MP0000477_abnormal_intestine_morphology0.65588287
143MP0001873_stomach_inflammation0.64876827
144MP0009785_altered_susceptibility_to0.63856052
145MP0004197_abnormal_fetal_growth/weight/0.63306709
146MP0010030_abnormal_orbit_morphology0.62408246
147MP0003937_abnormal_limbs/digits/tail_de0.61996756
148MP0010155_abnormal_intestine_physiology0.61097693
149MP0002405_respiratory_system_inflammati0.60983967
150MP0001853_heart_inflammation0.60787379
151MP0000015_abnormal_ear_pigmentation0.58994663
152MP0005671_abnormal_response_to0.58383132
153MP0002723_abnormal_immune_serum0.56425723
154MP0003866_abnormal_defecation0.55443316
155MP0005025_abnormal_response_to0.54965443
156MP0005023_abnormal_wound_healing0.54625304
157MP0000358_abnormal_cell_content/0.54012329
158MP0003436_decreased_susceptibility_to0.53609436
159MP0005389_reproductive_system_phenotype0.53511034

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.29022039
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.04983748
3Birth length less than 3rd percentile (HP:0003561)4.88568570
4Aplastic anemia (HP:0001915)4.81435338
5Reticulocytopenia (HP:0001896)4.44226435
6Breast hypoplasia (HP:0003187)4.00812170
7Abnormal number of erythroid precursors (HP:0012131)3.97816317
8Oral leukoplakia (HP:0002745)3.94850434
9Abnormality of cells of the erythroid lineage (HP:0012130)3.87973557
10Abnormality of chromosome stability (HP:0003220)3.81497732
11Abnormality of the preputium (HP:0100587)3.78239160
12Myelodysplasia (HP:0002863)3.67582962
13Duodenal stenosis (HP:0100867)3.60862626
14Small intestinal stenosis (HP:0012848)3.60862626
15Meckel diverticulum (HP:0002245)3.59509219
16Patellar aplasia (HP:0006443)3.58704180
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.50274280
18Abnormality of the ileum (HP:0001549)3.44035210
19Aplasia/Hypoplasia of the patella (HP:0006498)3.30107287
20Thrombocytosis (HP:0001894)3.27244443
21Carpal bone hypoplasia (HP:0001498)3.19054864
22Bone marrow hypocellularity (HP:0005528)3.00606730
23Pancreatic cysts (HP:0001737)2.96377467
24Acute necrotizing encephalopathy (HP:0006965)2.92318912
25Abnormality of the heme biosynthetic pathway (HP:0010472)2.91946615
26Male infertility (HP:0003251)2.89520550
27Abnormal mitochondria in muscle tissue (HP:0008316)2.89287080
28Abnormality of the duodenum (HP:0002246)2.83468899
29Abnormal lung lobation (HP:0002101)2.80694264
30Sloping forehead (HP:0000340)2.80689940
31Abnormality of midbrain morphology (HP:0002418)2.78350339
32Molar tooth sign on MRI (HP:0002419)2.78350339
33Mitochondrial inheritance (HP:0001427)2.73434308
34Acute encephalopathy (HP:0006846)2.73311953
35Pendular nystagmus (HP:0012043)2.72952354
36Colon cancer (HP:0003003)2.68714931
37Increased CSF lactate (HP:0002490)2.66452654
38Pancreatic fibrosis (HP:0100732)2.65997785
39Clubbing of toes (HP:0100760)2.62068155
40Rough bone trabeculation (HP:0100670)2.59191339
41Abnormality of the labia minora (HP:0012880)2.58355500
42Pulmonary fibrosis (HP:0002206)2.56530328
43Pallor (HP:0000980)2.54505141
44Ectopic kidney (HP:0000086)2.53956706
45Absent thumb (HP:0009777)2.53885106
46Abnormality of alanine metabolism (HP:0010916)2.52955752
47Hyperalaninemia (HP:0003348)2.52955752
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52955752
49Nephroblastoma (Wilms tumor) (HP:0002667)2.51917469
50Duplicated collecting system (HP:0000081)2.51225261
51Impulsivity (HP:0100710)2.50229691
52Medulloblastoma (HP:0002885)2.49659280
53Lipid accumulation in hepatocytes (HP:0006561)2.49050277
54True hermaphroditism (HP:0010459)2.48856183
55Hepatocellular necrosis (HP:0001404)2.48746050
56Abnormality of DNA repair (HP:0003254)2.48524967
57Abnormality of the carotid arteries (HP:0005344)2.47543715
58Premature ovarian failure (HP:0008209)2.47285545
59Increased hepatocellular lipid droplets (HP:0006565)2.46246843
60Microretrognathia (HP:0000308)2.45849168
61Increased nuchal translucency (HP:0010880)2.42706146
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41784890
63Congenital stationary night blindness (HP:0007642)2.40289340
64Hepatic necrosis (HP:0002605)2.37695836
65Degeneration of anterior horn cells (HP:0002398)2.34058766
66Abnormality of the anterior horn cell (HP:0006802)2.34058766
67Nephronophthisis (HP:0000090)2.32519709
68Abnormality of the renal collecting system (HP:0004742)2.32413435
69Short thumb (HP:0009778)2.30664142
70Hypoplasia of the pons (HP:0012110)2.29167812
71Embryonal renal neoplasm (HP:0011794)2.29078387
72Cerebellar dysplasia (HP:0007033)2.28881690
73Sclerocornea (HP:0000647)2.28820584
74Absent radius (HP:0003974)2.27193131
75Rhabdomyosarcoma (HP:0002859)2.25410065
76Hyperglycinemia (HP:0002154)2.25028324
77Increased serum lactate (HP:0002151)2.24095188
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22701938
79Abnormality of the fingertips (HP:0001211)2.22232478
8011 pairs of ribs (HP:0000878)2.21904251
81Selective tooth agenesis (HP:0001592)2.21311790
82IgM deficiency (HP:0002850)2.21019298
83Progressive macrocephaly (HP:0004481)2.20024247
84Abnormality of the pons (HP:0007361)2.19118824
85Secondary amenorrhea (HP:0000869)2.18358754
86Cafe-au-lait spot (HP:0000957)2.16507082
87Pancytopenia (HP:0001876)2.15893097
88Tracheoesophageal fistula (HP:0002575)2.15667093
89Triphalangeal thumb (HP:0001199)2.14688023
90Agnosia (HP:0010524)2.13448132
91Poikiloderma (HP:0001029)2.13004353
92Premature graying of hair (HP:0002216)2.12099593
93Aplasia involving forearm bones (HP:0009822)2.10593778
94Absent forearm bone (HP:0003953)2.10593778
95Acute myeloid leukemia (HP:0004808)2.10396683
96Type II lissencephaly (HP:0007260)2.09895315
97Macrocytic anemia (HP:0001972)2.09015034
98Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08407920
99Volvulus (HP:0002580)2.05990908
100Cellular immunodeficiency (HP:0005374)2.03175964
101Lissencephaly (HP:0001339)2.00126646
102Attenuation of retinal blood vessels (HP:0007843)1.99634582
103Renal Fanconi syndrome (HP:0001994)1.98511498
104Horseshoe kidney (HP:0000085)1.97831226
105Neoplasm of the colon (HP:0100273)1.97800289
106Type I transferrin isoform profile (HP:0003642)1.97492550
107Petechiae (HP:0000967)1.96546297
108Aplasia/Hypoplasia of the sternum (HP:0006714)1.96015192
109Facial hemangioma (HP:0000329)1.95779024
110Neoplasm of the pancreas (HP:0002894)1.94794349
111Anencephaly (HP:0002323)1.94718711
112Muscle fiber atrophy (HP:0100295)1.93671646
113Retinal dysplasia (HP:0007973)1.92701462
114Abnormality of reticulocytes (HP:0004312)1.92580761
115Abnormality of the prostate (HP:0008775)1.92546311
116Cerebral edema (HP:0002181)1.91644842
117Medial flaring of the eyebrow (HP:0010747)1.91553982
118Cystic liver disease (HP:0006706)1.88910712
119Acute lymphatic leukemia (HP:0006721)1.88014380
120Hypergonadotropic hypogonadism (HP:0000815)1.87789143
121Squamous cell carcinoma (HP:0002860)1.87688782
122Lymphoma (HP:0002665)1.86957542
123Increased intramyocellular lipid droplets (HP:0012240)1.86682782
124Septo-optic dysplasia (HP:0100842)1.85163529
125Basal cell carcinoma (HP:0002671)1.83935182
126Exertional dyspnea (HP:0002875)1.83804889
127Optic disc pallor (HP:0000543)1.83571614
128Slender long bone (HP:0003100)1.83338326
129High pitched voice (HP:0001620)1.83146209
130Lactic acidosis (HP:0003128)1.82911499
131Preaxial hand polydactyly (HP:0001177)1.82757898
132Abnormal trabecular bone morphology (HP:0100671)1.82070476
133Abnormal spermatogenesis (HP:0008669)1.81493517
134Dandy-Walker malformation (HP:0001305)1.81431058
135Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81338912
136Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81338912
137Abnormality of the renal medulla (HP:0100957)1.81305717
138Type 2 muscle fiber atrophy (HP:0003554)1.79171517
139Leukopenia (HP:0001882)1.78966373
140Overlapping toe (HP:0001845)1.78318422
141Flat capital femoral epiphysis (HP:0003370)1.78185822
142Irregular epiphyses (HP:0010582)1.78021296
143Methylmalonic acidemia (HP:0002912)1.76773545
144Entropion (HP:0000621)1.76707052
145Methylmalonic aciduria (HP:0012120)1.73361186
146Prominent nose (HP:0000448)1.72839006
147Abnormal protein glycosylation (HP:0012346)1.72799842
148Abnormal glycosylation (HP:0012345)1.72799842
149Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72799842
150Abnormal protein N-linked glycosylation (HP:0012347)1.72799842
151Partial agenesis of the corpus callosum (HP:0001338)1.72773629
152Oligohydramnios (HP:0001562)1.72719248
153Nephrogenic diabetes insipidus (HP:0009806)1.71154610
154Aplasia/Hypoplasia of the tongue (HP:0010295)1.69670664
155Holoprosencephaly (HP:0001360)1.69199974
156Cleft eyelid (HP:0000625)1.66692807
157Abnormality of serum amino acid levels (HP:0003112)1.66673611
158Supernumerary spleens (HP:0009799)1.66352860
159Neoplasm of the adrenal cortex (HP:0100641)1.66315867

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.99387225
2WEE13.96147419
3CDC73.87783725
4NEK23.55525280
5TTK3.18489652
6BRSK22.63635856
7PLK42.63193864
8VRK22.55998595
9EIF2AK12.42503502
10PBK2.29334800
11PLK12.28442621
12BRSK12.05713861
13EEF2K2.04239253
14STK101.95084525
15AURKB1.94794559
16CCNB11.94274017
17PNCK1.92062529
18VRK11.90835996
19BMPR1B1.88888877
20WNK41.83845218
21MAP3K61.82683054
22NEK11.82667287
23TAOK31.81834977
24MAP4K21.78797643
25MOS1.71626862
26ACVR1B1.68545128
27CHEK21.67305078
28SRPK11.64235935
29MAP3K81.57522889
30CDK81.54323261
31STK41.50287378
32CDK71.45267796
33AURKA1.42209995
34TRIM281.40931877
35DYRK31.40082217
36ADRBK21.39834115
37WNK31.39350712
38STK161.38369223
39FLT31.38027781
40TESK21.37698422
41ATR1.36710945
42FRK1.35240747
43CDK41.33235268
44BCKDK1.32571343
45MELK1.30607590
46NME11.29843884
47NME21.29829011
48RPS6KB21.28817248
49TAF11.27456581
50PLK31.19173965
51MAP4K11.14221214
52BMPR21.13451240
53BRAF1.10566445
54EIF2AK31.08055954
55MAPKAPK31.05921022
56KIT1.04283222
57RPS6KA41.00916518
58LATS11.00216454
59RAF10.98305635
60INSRR0.94974011
61CHEK10.92286474
62GRK10.91344356
63MKNK10.91080606
64TLK10.89426304
65STK390.86346460
66STK38L0.84313230
67LATS20.83610158
68STK30.83224934
69CSNK1G30.80125360
70PIM10.76956146
71PAK40.76305743
72CSNK1G10.76077601
73MAP3K40.76013215
74MAP2K70.70433609
75PIM20.69637510
76RPS6KA50.68843729
77ATM0.68278433
78CSNK1A1L0.68044085
79ZAK0.65607873
80TNIK0.65581928
81PINK10.65213318
82TAOK10.63091626
83MAP3K100.62728875
84MAPK150.62585565
85LRRK20.61466153
86TSSK60.61101954
87TEC0.58039124
88CDK20.57710831
89MKNK20.56677012
90PAK10.56413315
91MST40.55578639
92EIF2AK20.55435682
93CSNK1G20.55415856
94BTK0.55182589
95MAP2K30.54261462
96CSF1R0.53863565
97CDK10.53344679
98PASK0.53281191
99MUSK0.53117318
100SCYL20.52303431
101CDK190.52166004
102CDK60.51998407
103MAPK110.51996317
104CDK90.51276014
105PKN20.50615731
106DYRK20.50600713
107OXSR10.49907181
108MAPK130.49451279
109PDK20.47453507
110CDK120.46670107
111PRKCG0.46106945
112MAP2K20.45687694
113BRD40.45681154
114MAPKAPK50.44011104
115ABL20.42916465
116MAP3K110.41291997
117CSNK2A10.40960991
118NEK90.39042629
119TGFBR10.37021714
120IRAK40.36597653
121JAK30.35679524
122ERBB40.31739384
123CLK10.31089756
124PKN10.29432512
125KSR20.29375536
126ZAP700.28491123
127PLK20.28158081
128ILK0.27294143
129ADRBK10.27249255
130CAMK1D0.27180519
131MAP3K120.26998807
132KDR0.26466164
133CSNK2A20.26232757
134CDK30.25070507
135AKT20.24195315
136MAP3K50.23918598
137PRKDC0.23485994
138NUAK10.23418199
139NLK0.22443370
140PRKCI0.21269036
141LYN0.20925766
142MAP3K130.20352031
143TRPM70.19732463

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.43363851
2Mismatch repair_Homo sapiens_hsa034304.26132617
3Base excision repair_Homo sapiens_hsa034103.76072312
4Cell cycle_Homo sapiens_hsa041103.65774117
5Homologous recombination_Homo sapiens_hsa034403.56804656
6Nucleotide excision repair_Homo sapiens_hsa034202.95208042
7RNA polymerase_Homo sapiens_hsa030202.82085484
8Fanconi anemia pathway_Homo sapiens_hsa034602.80898647
9Spliceosome_Homo sapiens_hsa030402.74573263
10Ribosome_Homo sapiens_hsa030102.73813575
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.72810036
12RNA transport_Homo sapiens_hsa030132.68613437
13Pyrimidine metabolism_Homo sapiens_hsa002402.51485353
14RNA degradation_Homo sapiens_hsa030182.43463506
15Non-homologous end-joining_Homo sapiens_hsa034502.26737286
16Oxidative phosphorylation_Homo sapiens_hsa001902.24426183
17Basal transcription factors_Homo sapiens_hsa030222.18349355
18Proteasome_Homo sapiens_hsa030502.16304400
19Parkinsons disease_Homo sapiens_hsa050122.07308585
20One carbon pool by folate_Homo sapiens_hsa006701.92734349
21p53 signaling pathway_Homo sapiens_hsa041151.85303541
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63344659
23Oocyte meiosis_Homo sapiens_hsa041141.60245946
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.57395041
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48941931
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47059383
27mRNA surveillance pathway_Homo sapiens_hsa030151.40628862
28Purine metabolism_Homo sapiens_hsa002301.30958183
29Systemic lupus erythematosus_Homo sapiens_hsa053221.23939193
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19578048
31Vitamin B6 metabolism_Homo sapiens_hsa007501.19003945
32Herpes simplex infection_Homo sapiens_hsa051681.06212042
33Alzheimers disease_Homo sapiens_hsa050101.06143083
34Phototransduction_Homo sapiens_hsa047441.02451561
35Pentose phosphate pathway_Homo sapiens_hsa000301.02034605
36Epstein-Barr virus infection_Homo sapiens_hsa051691.00337113
37Butanoate metabolism_Homo sapiens_hsa006500.99990936
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98316452
39Folate biosynthesis_Homo sapiens_hsa007900.97938414
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97487222
41Steroid biosynthesis_Homo sapiens_hsa001000.95903539
42Propanoate metabolism_Homo sapiens_hsa006400.95379167
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92711416
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90540754
45Nitrogen metabolism_Homo sapiens_hsa009100.88919610
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87425244
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.87142728
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87080598
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.86596669
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85864864
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83468072
52Pyruvate metabolism_Homo sapiens_hsa006200.82510860
53Viral carcinogenesis_Homo sapiens_hsa052030.82097049
54HTLV-I infection_Homo sapiens_hsa051660.77579695
55Protein export_Homo sapiens_hsa030600.74481519
56MicroRNAs in cancer_Homo sapiens_hsa052060.69938523
57Small cell lung cancer_Homo sapiens_hsa052220.69755823
58Peroxisome_Homo sapiens_hsa041460.68443738
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.67684571
60Antigen processing and presentation_Homo sapiens_hsa046120.67504286
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67454538
62Cardiac muscle contraction_Homo sapiens_hsa042600.66689551
63Thyroid cancer_Homo sapiens_hsa052160.66616230
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65246467
65Fatty acid elongation_Homo sapiens_hsa000620.63716020
66Primary immunodeficiency_Homo sapiens_hsa053400.62540254
67Glutathione metabolism_Homo sapiens_hsa004800.62324572
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62205639
69Selenocompound metabolism_Homo sapiens_hsa004500.61524491
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61068081
71N-Glycan biosynthesis_Homo sapiens_hsa005100.59464574
72Tryptophan metabolism_Homo sapiens_hsa003800.58679205
73Biosynthesis of amino acids_Homo sapiens_hsa012300.56684558
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55998129
75Nicotine addiction_Homo sapiens_hsa050330.55698911
76Apoptosis_Homo sapiens_hsa042100.55451763
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55003403
78Vitamin digestion and absorption_Homo sapiens_hsa049770.54677262
79Fatty acid metabolism_Homo sapiens_hsa012120.52470571
80Pancreatic cancer_Homo sapiens_hsa052120.52387526
81Ether lipid metabolism_Homo sapiens_hsa005650.51776685
82Other glycan degradation_Homo sapiens_hsa005110.51563442
83Basal cell carcinoma_Homo sapiens_hsa052170.49358763
84Hepatitis B_Homo sapiens_hsa051610.49263360
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47412926
86Shigellosis_Homo sapiens_hsa051310.46817584
87Colorectal cancer_Homo sapiens_hsa052100.46688406
88Sulfur relay system_Homo sapiens_hsa041220.46360831
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44603032
90Notch signaling pathway_Homo sapiens_hsa043300.43304474
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43160447
92Chronic myeloid leukemia_Homo sapiens_hsa052200.42340646
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41346381
94Lysine degradation_Homo sapiens_hsa003100.37951619
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36979241
96Olfactory transduction_Homo sapiens_hsa047400.36847658
97Arginine and proline metabolism_Homo sapiens_hsa003300.36704233
98Influenza A_Homo sapiens_hsa051640.36502640
99TGF-beta signaling pathway_Homo sapiens_hsa043500.36294130
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.36268979
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.35955364
102Hedgehog signaling pathway_Homo sapiens_hsa043400.35361674
103Caffeine metabolism_Homo sapiens_hsa002320.35173258
104Non-small cell lung cancer_Homo sapiens_hsa052230.35057989
105Ovarian steroidogenesis_Homo sapiens_hsa049130.34357605
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34153791
107Hematopoietic cell lineage_Homo sapiens_hsa046400.34008422
108Bladder cancer_Homo sapiens_hsa052190.33645648
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33568280
110Measles_Homo sapiens_hsa051620.33469152
111Galactose metabolism_Homo sapiens_hsa000520.32679713
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32260995
113Alcoholism_Homo sapiens_hsa050340.32055444
114Huntingtons disease_Homo sapiens_hsa050160.31519912
115Taste transduction_Homo sapiens_hsa047420.31191094
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30933886
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30803100
118Fat digestion and absorption_Homo sapiens_hsa049750.29004755
119Arachidonic acid metabolism_Homo sapiens_hsa005900.27535511
120Regulation of autophagy_Homo sapiens_hsa041400.27271950
121Circadian rhythm_Homo sapiens_hsa047100.25754615
122Legionellosis_Homo sapiens_hsa051340.25568388
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.25321648
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24531333
125Leishmaniasis_Homo sapiens_hsa051400.23503520
126Sulfur metabolism_Homo sapiens_hsa009200.23289587
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.23258720
128Fatty acid biosynthesis_Homo sapiens_hsa000610.23092140
129Acute myeloid leukemia_Homo sapiens_hsa052210.21839418
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21662666
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20719850
132Chemical carcinogenesis_Homo sapiens_hsa052040.20531657
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.19903431
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19766475
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19692872
136FoxO signaling pathway_Homo sapiens_hsa040680.19085974
137Metabolic pathways_Homo sapiens_hsa011000.18871538
138Carbon metabolism_Homo sapiens_hsa012000.18688455
139Renin-angiotensin system_Homo sapiens_hsa046140.18518370
140Linoleic acid metabolism_Homo sapiens_hsa005910.18047434
141mTOR signaling pathway_Homo sapiens_hsa041500.17483450
142Pathways in cancer_Homo sapiens_hsa052000.14287141
143Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.14016679
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13695138
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12018055
146B cell receptor signaling pathway_Homo sapiens_hsa046620.11091413
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.10060318
148HIF-1 signaling pathway_Homo sapiens_hsa040660.09875574

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