ARHGEF19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.87998183
2L-phenylalanine catabolic process (GO:0006559)6.87998183
3L-phenylalanine metabolic process (GO:0006558)6.57515243
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.57515243
5aromatic amino acid family catabolic process (GO:0009074)5.87140129
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.55240328
7bile acid biosynthetic process (GO:0006699)5.18996370
8alpha-linolenic acid metabolic process (GO:0036109)5.13152673
9cysteine metabolic process (GO:0006534)5.12602311
10glyoxylate metabolic process (GO:0046487)5.11225219
11establishment of integrated proviral latency (GO:0075713)5.10496325
12kynurenine metabolic process (GO:0070189)5.07719711
13indole-containing compound catabolic process (GO:0042436)5.05458106
14indolalkylamine catabolic process (GO:0046218)5.05458106
15tryptophan catabolic process (GO:0006569)5.05458106
16sulfur amino acid catabolic process (GO:0000098)4.99972571
17high-density lipoprotein particle remodeling (GO:0034375)4.83408713
18heterochromatin organization (GO:0070828)4.76155437
19tryptophan metabolic process (GO:0006568)4.71744219
20negative regulation of fibrinolysis (GO:0051918)4.68587470
21urea cycle (GO:0000050)4.67102858
22urea metabolic process (GO:0019627)4.67102858
23DNA unwinding involved in DNA replication (GO:0006268)4.59986138
24protein carboxylation (GO:0018214)4.57765947
25peptidyl-glutamic acid carboxylation (GO:0017187)4.57765947
26regulation of fibrinolysis (GO:0051917)4.49642955
27bile acid metabolic process (GO:0008206)4.44884808
28serine family amino acid catabolic process (GO:0009071)4.43844592
29regulation of posttranscriptional gene silencing (GO:0060147)4.43823408
30regulation of gene silencing by miRNA (GO:0060964)4.43823408
31regulation of gene silencing by RNA (GO:0060966)4.43823408
32regulation of triglyceride catabolic process (GO:0010896)4.41366630
33nitrogen cycle metabolic process (GO:0071941)4.41193739
34regulation of cholesterol esterification (GO:0010872)4.40605276
35homocysteine metabolic process (GO:0050667)4.40226495
36DNA strand elongation involved in DNA replication (GO:0006271)4.37010996
37planar cell polarity pathway involved in neural tube closure (GO:0090179)4.31724346
38amino-acid betaine metabolic process (GO:0006577)4.29769016
39reverse cholesterol transport (GO:0043691)4.29603323
40regulation of protein activation cascade (GO:2000257)4.28490144
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.28294632
42aromatic amino acid family metabolic process (GO:0009072)4.22077221
43complement activation, alternative pathway (GO:0006957)4.20652009
44DNA strand elongation (GO:0022616)4.18799994
45lysine metabolic process (GO:0006553)4.18175903
46lysine catabolic process (GO:0006554)4.18175903
47protein-lipid complex remodeling (GO:0034368)4.14685737
48macromolecular complex remodeling (GO:0034367)4.14685737
49plasma lipoprotein particle remodeling (GO:0034369)4.14685737
50tyrosine metabolic process (GO:0006570)4.14220153
51alpha-amino acid catabolic process (GO:1901606)4.11101090
52cellular ketone body metabolic process (GO:0046950)4.08813799
53glutamate metabolic process (GO:0006536)4.05892616
54establishment of viral latency (GO:0019043)4.00447828
55regulation of complement activation (GO:0030449)3.99887606
56plasma lipoprotein particle clearance (GO:0034381)3.97311900
57acylglycerol homeostasis (GO:0055090)3.96985941
58triglyceride homeostasis (GO:0070328)3.96985941
59negative regulation of sterol transport (GO:0032372)3.96920419
60negative regulation of cholesterol transport (GO:0032375)3.96920419
61ethanol oxidation (GO:0006069)3.93810217
62cellular modified amino acid catabolic process (GO:0042219)3.93344557
63pre-miRNA processing (GO:0031054)3.93159773
64regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.92739995
65phospholipid efflux (GO:0033700)3.92649321
66protein complex localization (GO:0031503)3.91200215
67telomere maintenance via semi-conservative replication (GO:0032201)3.91034277
68peptidyl-arginine omega-N-methylation (GO:0035247)3.90918078
69regulation of cholesterol homeostasis (GO:2000188)3.89940374
70cellular glucuronidation (GO:0052695)3.87769922
71coenzyme catabolic process (GO:0009109)3.87193991
72cellular amino acid catabolic process (GO:0009063)3.86550561
73histone arginine methylation (GO:0034969)3.84416686
74regulation of bile acid biosynthetic process (GO:0070857)3.82516383
75acetyl-CoA metabolic process (GO:0006084)3.77280152
76short-chain fatty acid metabolic process (GO:0046459)3.75404948
77cholesterol efflux (GO:0033344)3.74647134
78serine family amino acid metabolic process (GO:0009069)3.70492493
79bile acid and bile salt transport (GO:0015721)3.68736627
80glycine metabolic process (GO:0006544)3.64838526
81fibrinolysis (GO:0042730)3.60471355
82serine family amino acid biosynthetic process (GO:0009070)3.59436751
83plasma lipoprotein particle assembly (GO:0034377)3.57015578
84positive regulation of lipoprotein lipase activity (GO:0051006)3.55823241
85positive regulation of triglyceride lipase activity (GO:0061365)3.55823241
86very-low-density lipoprotein particle assembly (GO:0034379)3.54808510
87benzene-containing compound metabolic process (GO:0042537)3.52982581
88amine catabolic process (GO:0009310)3.52798358
89cellular biogenic amine catabolic process (GO:0042402)3.52798358
90aspartate family amino acid catabolic process (GO:0009068)3.52517308
91ketone body metabolic process (GO:1902224)3.51998301
92intestinal cholesterol absorption (GO:0030299)3.50559186
93uronic acid metabolic process (GO:0006063)3.49481633
94glucuronate metabolic process (GO:0019585)3.49481633
95regulation of cell fate specification (GO:0042659)3.49286093
96cholesterol homeostasis (GO:0042632)3.49229364
97dicarboxylic acid biosynthetic process (GO:0043650)3.48659654
98indolalkylamine metabolic process (GO:0006586)3.48432891
99negative regulation of lipase activity (GO:0060192)3.47268659
100viral transcription (GO:0019083)3.47177915
101organic acid catabolic process (GO:0016054)3.46134969
102carboxylic acid catabolic process (GO:0046395)3.46134969
103low-density lipoprotein particle remodeling (GO:0034374)3.45391303
104regulation of cholesterol metabolic process (GO:0090181)3.44709014
105sterol homeostasis (GO:0055092)3.43206997
106negative regulation of cell fate specification (GO:0009996)3.42533251
107fatty acid beta-oxidation (GO:0006635)3.41762507
108arginine metabolic process (GO:0006525)3.39020677
109imidazole-containing compound metabolic process (GO:0052803)3.37781167
110protein-lipid complex assembly (GO:0065005)3.37723139
111mitotic chromosome condensation (GO:0007076)3.37545033
112very long-chain fatty acid metabolic process (GO:0000038)3.37091409
113drug catabolic process (GO:0042737)3.37021345
114paraxial mesoderm development (GO:0048339)3.36957107
115monocarboxylic acid catabolic process (GO:0072329)3.36859877
116desmosome organization (GO:0002934)3.36834250
117positive regulation of fatty acid beta-oxidation (GO:0032000)3.36337174
118DNA replication initiation (GO:0006270)3.36312035
119establishment of apical/basal cell polarity (GO:0035089)3.35822757
120protein-DNA complex disassembly (GO:0032986)3.35563636
121nucleosome disassembly (GO:0006337)3.35563636
122positive regulation of lipid catabolic process (GO:0050996)3.33991620
123formation of translation preinitiation complex (GO:0001731)3.33062020
124fatty acid oxidation (GO:0019395)3.32884300
125heme transport (GO:0015886)3.32223692
126translational termination (GO:0006415)3.31714669
127peptidyl-arginine methylation (GO:0018216)3.29057735
128peptidyl-arginine N-methylation (GO:0035246)3.29057735
129lipid oxidation (GO:0034440)3.28918488
130ribosomal small subunit assembly (GO:0000028)3.27728612
131fatty acid catabolic process (GO:0009062)3.27427627
132ribosomal small subunit biogenesis (GO:0042274)3.25905858
133regulation of translational fidelity (GO:0006450)3.25076956
134L-serine metabolic process (GO:0006563)3.22214903
135convergent extension (GO:0060026)3.21631377
136proline biosynthetic process (GO:0006561)3.21620741
137telomere maintenance via recombination (GO:0000722)3.21303659
138protein localization to kinetochore (GO:0034501)3.15141304
139regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.12346819
140maturation of SSU-rRNA (GO:0030490)3.11865847
141cellular protein complex localization (GO:0034629)3.09356938
142nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.06233114
143mitotic recombination (GO:0006312)3.04757878
144pentose-phosphate shunt (GO:0006098)3.02298076
145telomere maintenance via telomere lengthening (GO:0010833)3.01026080
146DNA duplex unwinding (GO:0032508)3.00962241
147regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.99733806
148IMP biosynthetic process (GO:0006188)2.99635602
149base-excision repair (GO:0006284)2.97536989
150translational elongation (GO:0006414)2.95475100
151DNA replication checkpoint (GO:0000076)2.91407253
152negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90826019
153NADPH regeneration (GO:0006740)2.90579276
154SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87868323
155DNA geometric change (GO:0032392)2.87103451
156negative regulation of cell fate commitment (GO:0010454)2.82185974
157mitotic metaphase plate congression (GO:0007080)2.81751281
158regulation of water loss via skin (GO:0033561)2.80636469
159translational initiation (GO:0006413)2.80176415
160IMP metabolic process (GO:0046040)2.79481717
161protein targeting to ER (GO:0045047)2.79210720
162positive regulation of SMAD protein import into nucleus (GO:0060391)2.78919651
163cotranslational protein targeting to membrane (GO:0006613)2.78487327
164DNA ligation (GO:0006266)2.75060873
165chromatin assembly (GO:0031497)2.74722935
166nuclear pore complex assembly (GO:0051292)2.73723807
167mitotic G1 DNA damage checkpoint (GO:0031571)2.73454937
168bundle of His cell to Purkinje myocyte communication (GO:0086069)2.73356240
169ribosomal large subunit biogenesis (GO:0042273)2.72684133
170nucleobase biosynthetic process (GO:0046112)2.70188181
171branching involved in salivary gland morphogenesis (GO:0060445)2.69228175
172viral life cycle (GO:0019058)2.69004243
173negative regulation of histone methylation (GO:0031061)2.68739239
174establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66438285
175folic acid-containing compound biosynthetic process (GO:0009396)2.63757930
176pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.62440578
177negative regulation of mRNA metabolic process (GO:1903312)2.62431173
178ribonucleoprotein complex biogenesis (GO:0022613)2.60202726
179rRNA transcription (GO:0009303)2.59397719
180glucose catabolic process (GO:0006007)2.59095596
181hyperosmotic salinity response (GO:0042538)2.58576683
182protein complex disassembly (GO:0043241)2.58180983
183protein localization to endoplasmic reticulum (GO:0070972)2.56991293
184negative regulation of telomerase activity (GO:0051974)2.56774406
185regulation of mammary gland epithelial cell proliferation (GO:0033599)2.54961493
186Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.54500504
187telomere maintenance via telomerase (GO:0007004)2.54388297
188establishment of monopolar cell polarity (GO:0061162)2.54038263
189establishment or maintenance of monopolar cell polarity (GO:0061339)2.54038263
190RNA-dependent DNA replication (GO:0006278)2.53629316
191positive regulation of Cdc42 GTPase activity (GO:0043089)2.52960401
192cellular protein complex disassembly (GO:0043624)2.51148778
193negative regulation of mRNA processing (GO:0050686)2.50842376
194negative regulation of RNA splicing (GO:0033119)2.49675466
195DNA topological change (GO:0006265)2.48360198
196DNA conformation change (GO:0071103)2.48335949
197protein localization to chromosome, centromeric region (GO:0071459)2.47589549
198activation of Rac GTPase activity (GO:0032863)2.46869556
199purine nucleobase biosynthetic process (GO:0009113)2.46751701
200lateral sprouting from an epithelium (GO:0060601)2.46188233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.59076832
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.74213356
3E2F7_22180533_ChIP-Seq_HELA_Human6.33452230
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.82895473
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.44671918
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.85376700
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.29227799
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.28520599
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.54161576
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.53883531
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.44606085
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20727030
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.94374223
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81071770
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76236017
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.53220651
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49267280
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.49022079
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41765750
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29929645
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27490108
22MYC_22102868_ChIP-Seq_BL_Human2.13771634
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.11957124
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.95809676
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92991696
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89028808
27CLOCK_20551151_ChIP-Seq_293T_Human1.87518217
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.86361841
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85337497
30XRN2_22483619_ChIP-Seq_HELA_Human1.84815272
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82240111
32CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79814236
33* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76579897
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73012507
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.71887133
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71195686
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69418361
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.67145412
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66386142
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65183177
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64308211
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.62392085
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61088212
44* ELK3_25401928_ChIP-Seq_HUVEC_Human1.60294684
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60213225
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.58022994
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.55729199
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55694443
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.54008139
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52535190
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51096836
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50470869
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50224020
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.49635661
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48111408
56DCP1A_22483619_ChIP-Seq_HELA_Human1.47908181
57AR_21909140_ChIP-Seq_LNCAP_Human1.47166072
58VDR_21846776_ChIP-Seq_THP-1_Human1.46979447
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45772350
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45772350
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45772350
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44267247
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38121968
64* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37397359
65TTF2_22483619_ChIP-Seq_HELA_Human1.36694677
66ZNF263_19887448_ChIP-Seq_K562_Human1.36233731
67ETS1_20019798_ChIP-Seq_JURKAT_Human1.32540751
68* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32476464
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31414125
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30535382
71TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29302859
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25881166
73* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24886883
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24288668
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23621911
76NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21792257
77KDM5A_27292631_Chip-Seq_BREAST_Human1.20646949
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19771822
79GABP_19822575_ChIP-Seq_HepG2_Human1.19389333
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19282909
81HTT_18923047_ChIP-ChIP_STHdh_Human1.18173991
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17944376
83HNF4A_19822575_ChIP-Seq_HepG2_Human1.17592012
84ATF3_27146783_Chip-Seq_COLON_Human1.16153913
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.15215915
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.14010077
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11932304
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.11685722
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.11376889
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11045649
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10915760
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.10240380
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10002998
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09372139
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08777671
96OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08720569
97TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08238811
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.06794586
99P68_20966046_ChIP-Seq_HELA_Human1.06140284
100TCF7_22412390_ChIP-Seq_EML_Mouse1.05251729
101SA1_27219007_Chip-Seq_ERYTHROID_Human1.04100998
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03401630
103HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03202548
104* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03098766
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02963912
106KAP1_27257070_Chip-Seq_ESCs_Mouse1.02760041
107NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02661858
108ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02199625
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02161263
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01852916
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.01460995
112SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01325032
113CHD1_26751641_Chip-Seq_LNCaP_Human0.99941149
114FOXP3_21729870_ChIP-Seq_TREG_Human0.99168281
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.98457595
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98391860
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98015874
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97996700
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97866631
120LXR_22292898_ChIP-Seq_THP-1_Human0.97268518
121FOXP1_21924763_ChIP-Seq_HESCs_Human0.96973499
122SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96824755
123GATA4_25053715_ChIP-Seq_YYC3_Human0.96752543
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95644990
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92128838
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92128838
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90546223
128AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89414877
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88501596
130* RACK7_27058665_Chip-Seq_MCF-7_Human0.87216931
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85576333
132RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85549514
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83954927
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83240263
135CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82602588
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82568353
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.81209645
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.80343206
139SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78256491
140* TBX20_22328084_ChIP-Seq_HEART_Mouse0.78094485
141* TBX20_22080862_ChIP-Seq_HEART_Mouse0.78094485
142SOX2_20726797_ChIP-Seq_SW620_Human0.77955612
143SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77602840
144AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76538168
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75524886
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75211710
147* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74880802
148* CTCF_27219007_Chip-Seq_Bcells_Human0.74754080
149* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.72730332
150EP300_21415370_ChIP-Seq_HL-1_Mouse0.72071964
151* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.70860255
152FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69951442
153ZNF217_24962896_ChIP-Seq_MCF-7_Human0.69042575
154DNAJC2_21179169_ChIP-ChIP_NT2_Human0.67969714
155* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66612602
156STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.66097001
157FOXA1_25552417_ChIP-Seq_VCAP_Human0.65489192
158ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64807742
159SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.64148184
160CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.63239461
161MTF2_20144788_ChIP-Seq_MESCs_Mouse0.62536481
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.61677365
163CREB1_26743006_Chip-Seq_LNCaP_Human0.60255604
164SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59811236
165EED_16625203_ChIP-ChIP_MESCs_Mouse0.58559890
166GATA1_19941826_ChIP-Seq_K562_Human0.58090656
167P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.57883061
168GATA1_22025678_ChIP-Seq_K562_Human0.57486945
169EZH2_18974828_ChIP-Seq_MESCs_Mouse0.57420537
170RNF2_18974828_ChIP-Seq_MESCs_Mouse0.57420537
171SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.57409988
172* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.57277619
173SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.56958012
174RARA_24833708_ChIP-Seq_LIVER_Mouse0.56194819
175GATA6_25053715_ChIP-Seq_YYC3_Human0.55972475
176CBP_21632823_ChIP-Seq_H3396_Human0.55871884
177* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.55005124
178CDX2_19796622_ChIP-Seq_MESCs_Mouse0.54766925
179BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54667490
180CTCF_20526341_ChIP-Seq_ESCs_Human0.54653113
181TP63_22573176_ChIP-Seq_HFKS_Human0.54606892
182PIAS1_25552417_ChIP-Seq_VCAP_Human0.54605115
183ESR1_15608294_ChIP-ChIP_MCF-7_Human0.53734916
184CEBPB_22108803_ChIP-Seq_LS180_Human0.53416234
185MYC_27129775_Chip-Seq_CORNEA_Mouse0.52853623
186RARB_24833708_ChIP-Seq_LIVER_Mouse0.52642492
187MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.52590777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.23966500
2MP0005360_urolithiasis6.90119897
3MP0005085_abnormal_gallbladder_physiolo5.75152374
4MP0005365_abnormal_bile_salt5.51283805
5MP0008875_abnormal_xenobiotic_pharmacok4.64734674
6MP0003806_abnormal_nucleotide_metabolis3.88521915
7MP0003252_abnormal_bile_duct3.64469566
8MP0009840_abnormal_foam_cell3.50040387
9MP0003693_abnormal_embryo_hatching3.17959208
10MP0010329_abnormal_lipoprotein_level3.16680889
11MP0003941_abnormal_skin_development3.10571611
12MP0005083_abnormal_biliary_tract3.06248349
13MP0003195_calcinosis2.88853601
14MP0004957_abnormal_blastocyst_morpholog2.83506702
15MP0001666_abnormal_nutrient_absorption2.78744834
16MP0005332_abnormal_amino_acid2.77100805
17MP0010094_abnormal_chromosome_stability2.59214682
18MP0003111_abnormal_nucleus_morphology2.53116862
19MP0001849_ear_inflammation2.50097581
20MP0005501_abnormal_skin_physiology2.43883210
21MP0005377_hearing/vestibular/ear_phenot2.12507653
22MP0003878_abnormal_ear_physiology2.12507653
23MP0008058_abnormal_DNA_repair2.08079470
24MP0003077_abnormal_cell_cycle2.05284302
25MP0002118_abnormal_lipid_homeostasis2.03428506
26MP0004264_abnormal_extraembryonic_tissu2.01395401
27MP0003191_abnormal_cellular_cholesterol1.95958279
28MP0008932_abnormal_embryonic_tissue1.95638227
29MP0009672_abnormal_birth_weight1.94883409
30MP0003705_abnormal_hypodermis_morpholog1.94038978
31MP0004019_abnormal_vitamin_homeostasis1.92924387
32MP0005076_abnormal_cell_differentiation1.87895502
33MP0000537_abnormal_urethra_morphology1.87187088
34MP0009379_abnormal_foot_pigmentation1.79298442
35MP0000609_abnormal_liver_physiology1.77863657
36MP0001730_embryonic_growth_arrest1.76440632
37MP0004858_abnormal_nervous_system1.65431333
38MP0003868_abnormal_feces_composition1.64748804
39MP0005451_abnormal_body_composition1.63162318
40MP0010352_gastrointestinal_tract_polyps1.56539227
41MP0005319_abnormal_enzyme/_coenzyme1.54960604
42MP0002254_reproductive_system_inflammat1.53038571
43MP0002396_abnormal_hematopoietic_system1.53001788
44MP0003566_abnormal_cell_adhesion1.49946750
45MP0002085_abnormal_embryonic_tissue1.45107517
46MP0008057_abnormal_DNA_replication1.44667527
47MP0002138_abnormal_hepatobiliary_system1.39242925
48MP0009278_abnormal_bone_marrow1.38852767
49MP0000350_abnormal_cell_proliferation1.38633434
50MP0001216_abnormal_epidermal_layer1.38191352
51MP0005584_abnormal_enzyme/coenzyme_acti1.35459239
52MP0003718_maternal_effect1.32772630
53MP0002111_abnormal_tail_morphology1.32643287
54MP0001672_abnormal_embryogenesis/_devel1.30024574
55MP0005380_embryogenesis_phenotype1.30024574
56MP0002697_abnormal_eye_size1.29632521
57MP0009384_cardiac_valve_regurgitation1.27708884
58MP0000579_abnormal_nail_morphology1.27625986
59MP0002080_prenatal_lethality1.27480458
60MP0005257_abnormal_intraocular_pressure1.25640270
61MP0001293_anophthalmia1.25382648
62MP0003690_abnormal_glial_cell1.25093102
63MP0006292_abnormal_olfactory_placode1.23147871
64MP0000490_abnormal_crypts_of1.22305218
65MP0003329_amyloid_beta_deposits1.21767886
66MP0010771_integument_phenotype1.20222861
67MP0002084_abnormal_developmental_patter1.19469969
68MP0003011_delayed_dark_adaptation1.18968651
69MP0001697_abnormal_embryo_size1.18799374
70MP0002089_abnormal_postnatal_growth/wei1.18426277
71MP0009643_abnormal_urine_homeostasis1.17502472
72MP0003984_embryonic_growth_retardation1.17207334
73MP0002088_abnormal_embryonic_growth/wei1.12193691
74MP0008438_abnormal_cutaneous_collagen1.10692712
75MP0000604_amyloidosis1.08632584
76MP0000678_abnormal_parathyroid_gland1.08492242
77MP0003786_premature_aging1.08022744
78MP0004233_abnormal_muscle_weight1.06492462
79MP0001881_abnormal_mammary_gland1.06306884
80MP0008007_abnormal_cellular_replicative1.06136887
81MP0000428_abnormal_craniofacial_morphol1.04483935
82MP0003315_abnormal_perineum_morphology1.03642884
83MP0000313_abnormal_cell_death1.03206372
84MP0004197_abnormal_fetal_growth/weight/1.01759723
85MP0002796_impaired_skin_barrier1.01142947
86MP0009931_abnormal_skin_appearance1.00399646
87MP0001764_abnormal_homeostasis0.98456346
88MP0002086_abnormal_extraembryonic_tissu0.97939583
89MP0003937_abnormal_limbs/digits/tail_de0.97193470
90MP0003123_paternal_imprinting0.96763750
91MP0000566_synostosis0.95701975
92MP0000049_abnormal_middle_ear0.95566765
93MP0002837_dystrophic_cardiac_calcinosis0.94383625
94MP0000627_abnormal_mammary_gland0.92454643
95MP0003119_abnormal_digestive_system0.92294938
96MP0003942_abnormal_urinary_system0.91976894
97MP0009703_decreased_birth_body0.91884952
98MP0001299_abnormal_eye_distance/0.88528883
99MP0005647_abnormal_sex_gland0.88080502
100MP0010307_abnormal_tumor_latency0.86942081
101MP0005275_abnormal_skin_tensile0.86354999
102MP0000598_abnormal_liver_morphology0.84651857
103MP0003115_abnormal_respiratory_system0.83589663
104MP0000432_abnormal_head_morphology0.83277177
105MP0002060_abnormal_skin_morphology0.82266269
106MP0009053_abnormal_anal_canal0.81639313
107MP0003656_abnormal_erythrocyte_physiolo0.81349516
108MP0001340_abnormal_eyelid_morphology0.79454703
109MP0004130_abnormal_muscle_cell0.78966037
110MP0000462_abnormal_digestive_system0.78649888
111MP0005408_hypopigmentation0.78588446
112MP0008995_early_reproductive_senescence0.78028040
113MP0003186_abnormal_redox_activity0.76114112
114MP0002092_abnormal_eye_morphology0.76060214
115MP0002019_abnormal_tumor_incidence0.76012574
116MP0000920_abnormal_myelination0.75403368
117MP0000858_altered_metastatic_potential0.75318066
118MP0005220_abnormal_exocrine_pancreas0.73765728
119MP0000647_abnormal_sebaceous_gland0.73374912
120MP0004381_abnormal_hair_follicle0.72738192
121MP0009697_abnormal_copulation0.72503586
122MP0001286_abnormal_eye_development0.72155089
123MP0005670_abnormal_white_adipose0.71764097
124MP0005636_abnormal_mineral_homeostasis0.71463246
125MP0010234_abnormal_vibrissa_follicle0.70854536
126MP0000477_abnormal_intestine_morphology0.70204639
127MP0002116_abnormal_craniofacial_bone0.70100509
128MP0001661_extended_life_span0.69348859
129MP0005508_abnormal_skeleton_morphology0.68144311
130MP0000639_abnormal_adrenal_gland0.68077508
131MP0010368_abnormal_lymphatic_system0.67296999
132MP0005666_abnormal_adipose_tissue0.67121895
133MP0001243_abnormal_dermal_layer0.67061575
134MP0010678_abnormal_skin_adnexa0.66757501
135MP0002971_abnormal_brown_adipose0.66094246
136MP0000467_abnormal_esophagus_morphology0.65820359
137MP0009642_abnormal_blood_homeostasis0.65801951
138MP0001188_hyperpigmentation0.65023917
139MP0002078_abnormal_glucose_homeostasis0.63373541
140MP0009763_increased_sensitivity_to0.62739945
141MP0004885_abnormal_endolymph0.62233237
142MP0005084_abnormal_gallbladder_morpholo0.61790350
143MP0000383_abnormal_hair_follicle0.61620541
144MP0002098_abnormal_vibrissa_morphology0.60244627
145MP0002295_abnormal_pulmonary_circulatio0.59577876
146MP0004185_abnormal_adipocyte_glucose0.58877717
147MP0005330_cardiomyopathy0.57799035
148MP0001756_abnormal_urination0.57433737
149MP0006036_abnormal_mitochondrial_physio0.56999383
150MP0009764_decreased_sensitivity_to0.56660057
151MP0005376_homeostasis/metabolism_phenot0.54917216
152MP0000762_abnormal_tongue_morphology0.54343852
153MP0003453_abnormal_keratinocyte_physiol0.53684131
154MP0001346_abnormal_lacrimal_gland0.51756304
155MP0004043_abnormal_pH_regulation0.51618566
156MP0005334_abnormal_fat_pad0.51319026
157MP0010030_abnormal_orbit_morphology0.51187200
158MP0000377_abnormal_hair_follicle0.49775229
159MP0002249_abnormal_larynx_morphology0.48236709
160MP0005395_other_phenotype0.47321429
161MP0005266_abnormal_metabolism0.46677787
162MP0005448_abnormal_energy_balance0.45378065
163MP0002168_other_aberrant_phenotype0.45312712
164MP0000427_abnormal_hair_cycle0.44394075
165MP0005248_abnormal_Harderian_gland0.43902727
166MP0004272_abnormal_basement_membrane0.43682488
167MP0002269_muscular_atrophy0.42436951
168MP0002896_abnormal_bone_mineralization0.40397561
169MP0002822_catalepsy0.39904554
170MP0005535_abnormal_body_temperature0.39532233
171MP0003638_abnormal_response/metabolism_0.38917616
172MP0003075_altered_response_to0.38895276
173MP0009765_abnormal_xenobiotic_induced0.38757602
174MP0009780_abnormal_chondrocyte_physiolo0.38261186
175MP0005375_adipose_tissue_phenotype0.38093084

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.72637404
2Deep venous thrombosis (HP:0002625)6.56459761
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.54401548
4Xanthomatosis (HP:0000991)6.01961768
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.96498432
6Hypobetalipoproteinemia (HP:0003563)5.27570033
7Prolonged partial thromboplastin time (HP:0003645)5.16959566
8Hyperlipoproteinemia (HP:0010980)5.15808336
9Selective tooth agenesis (HP:0001592)4.52546889
10Hyperammonemia (HP:0001987)4.30560121
11Pili torti (HP:0003777)4.27753240
12Hyperglycinemia (HP:0002154)4.23231047
13Hypolipoproteinemia (HP:0010981)4.20198175
14Hyperglycinuria (HP:0003108)4.16260612
15Complement deficiency (HP:0004431)4.14923007
16Abnormality of glycine metabolism (HP:0010895)4.10640084
17Abnormality of serine family amino acid metabolism (HP:0010894)4.10640084
18Ketosis (HP:0001946)4.09337466
19Epidermoid cyst (HP:0200040)4.03012182
20Hypoalphalipoproteinemia (HP:0003233)3.93322888
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.88284259
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.85824932
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.85006878
24Hypoglycemic coma (HP:0001325)3.80651211
25Fat malabsorption (HP:0002630)3.80295443
26Abnormality of methionine metabolism (HP:0010901)3.74205411
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.71033146
28Abnormality of the common coagulation pathway (HP:0010990)3.54091079
29Reticulocytopenia (HP:0001896)3.45817286
30Joint hemorrhage (HP:0005261)3.44283427
31Abnormality of fatty-acid metabolism (HP:0004359)3.38616681
32Conjugated hyperbilirubinemia (HP:0002908)3.38520525
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.22275889
34Ketoacidosis (HP:0001993)3.20441565
35Abnormality of the intrinsic pathway (HP:0010989)3.06632271
36Abnormality of complement system (HP:0005339)2.99602941
37Hypercholesterolemia (HP:0003124)2.96644073
38Delayed CNS myelination (HP:0002188)2.88984455
39Chromsome breakage (HP:0040012)2.87188607
40Steatorrhea (HP:0002570)2.83628818
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83420997
42Abnormal hair laboratory examination (HP:0003328)2.78213570
43Partial duplication of thumb phalanx (HP:0009944)2.74075986
44Gout (HP:0001997)2.73986476
45Hyperbilirubinemia (HP:0002904)2.72797940
46Abnormality of serum amino acid levels (HP:0003112)2.71657996
47Hyperacusis (HP:0010780)2.65678794
48Dicarboxylic aciduria (HP:0003215)2.63472693
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63472693
50Vascular calcification (HP:0004934)2.62666271
51Choanal stenosis (HP:0000452)2.61111186
52Myocardial infarction (HP:0001658)2.59841665
53Malnutrition (HP:0004395)2.59405251
54Skin nodule (HP:0200036)2.58658908
55Birth length less than 3rd percentile (HP:0003561)2.55618274
56Trismus (HP:0000211)2.51780746
57Metabolic acidosis (HP:0001942)2.51702620
58Abnormality of cells of the erythroid lineage (HP:0012130)2.50640226
59Abnormal number of erythroid precursors (HP:0012131)2.47328222
60Abnormality of pyrimidine metabolism (HP:0004353)2.46782487
61Facial cleft (HP:0002006)2.46296514
62Cardiovascular calcification (HP:0011915)2.44726953
63Abnormality of nucleobase metabolism (HP:0010932)2.43529152
64Abnormality of the salivary glands (HP:0010286)2.42065797
65Abnormality of purine metabolism (HP:0004352)2.41902485
66Abnormality of cochlea (HP:0000375)2.41869955
67Pterygium (HP:0001059)2.41459867
68Absent eyelashes (HP:0000561)2.39041032
69Lethargy (HP:0001254)2.38942902
70Abnormal gallbladder morphology (HP:0012437)2.37791416
71Mitral stenosis (HP:0001718)2.37306024
72Microvesicular hepatic steatosis (HP:0001414)2.36521626
73Abnormality of the lacrimal duct (HP:0011481)2.34577604
74Turricephaly (HP:0000262)2.32598253
75Chronic bronchitis (HP:0004469)2.30772584
76Cholelithiasis (HP:0001081)2.27989984
77Hepatocellular carcinoma (HP:0001402)2.27262969
78Atresia of the external auditory canal (HP:0000413)2.25379174
79Amyloidosis (HP:0011034)2.23454792
80Partial duplication of the phalanx of hand (HP:0009999)2.23213180
81Oral leukoplakia (HP:0002745)2.22275006
82Hypoglycemic seizures (HP:0002173)2.22272576
83Breast hypoplasia (HP:0003187)2.22268896
84Septo-optic dysplasia (HP:0100842)2.22053975
85Increased nuchal translucency (HP:0010880)2.21264678
86Rough bone trabeculation (HP:0100670)2.19455456
87Broad metatarsal (HP:0001783)2.18890617
88Hemorrhage of the eye (HP:0011885)2.18512523
89Right ventricular cardiomyopathy (HP:0011663)2.18355932
90Sparse eyelashes (HP:0000653)2.17629118
91High anterior hairline (HP:0009890)2.17339349
92Neonatal onset (HP:0003623)2.17180868
93Spontaneous abortion (HP:0005268)2.14693960
94Abnormal number of incisors (HP:0011064)2.12545852
95Irritability (HP:0000737)2.06497566
96Abnormality of the labia minora (HP:0012880)2.06445031
97Spastic paraparesis (HP:0002313)2.06203862
98Duplication of thumb phalanx (HP:0009942)2.05599984
99Late onset (HP:0003584)2.05459405
100Back pain (HP:0003418)2.04536070
101Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04445152
102Rickets (HP:0002748)2.03756955
103Esophageal atresia (HP:0002032)2.02938687
104Abnormal gallbladder physiology (HP:0012438)2.02128995
105Cholecystitis (HP:0001082)2.02128995
106Hydroxyprolinuria (HP:0003080)2.01155775
107Abnormality of proline metabolism (HP:0010907)2.01155775
108Overriding aorta (HP:0002623)2.01090054
109Spastic diplegia (HP:0001264)2.00301615
110Neurofibrillary tangles (HP:0002185)1.99807345
111Cerebral edema (HP:0002181)1.99560127
112Proximal placement of thumb (HP:0009623)1.99411595
113Hyperinsulinemic hypoglycemia (HP:0000825)1.99199801
114Fragile nails (HP:0001808)1.99035569
115Deviation of the thumb (HP:0009603)1.98515060
116Premature skin wrinkling (HP:0100678)1.98464776
117Aplasia/Hypoplasia of the breasts (HP:0010311)1.95737207
118Bilateral microphthalmos (HP:0007633)1.95606093
119Colon cancer (HP:0003003)1.94208456
120Progressive external ophthalmoplegia (HP:0000590)1.94000298
121Urethral obstruction (HP:0000796)1.93681011
122Bronchomalacia (HP:0002780)1.93515988
123Skull defect (HP:0001362)1.93094127
124Ankyloglossia (HP:0010296)1.92188960
125Generalized aminoaciduria (HP:0002909)1.91536762
126Hypophosphatemic rickets (HP:0004912)1.91171318
127Vomiting (HP:0002013)1.90735021
128Brushfield spots (HP:0001088)1.88906577
129Breast aplasia (HP:0100783)1.88471857
130Sensorimotor neuropathy (HP:0007141)1.87930402
131Abnormality of vitamin metabolism (HP:0100508)1.86764529
132Macrocytic anemia (HP:0001972)1.86237286
133Enlarged kidneys (HP:0000105)1.85824002
134Abnormal cartilage morphology (HP:0002763)1.85125818
135Abnormality of the gallbladder (HP:0005264)1.84028147
136Progressive muscle weakness (HP:0003323)1.83937867
137Myelomeningocele (HP:0002475)1.83856802
138Esophageal varix (HP:0002040)1.83556014
139Protuberant abdomen (HP:0001538)1.83314638
140Opisthotonus (HP:0002179)1.83111385
141Premature rupture of membranes (HP:0001788)1.82933295
142Pancreatitis (HP:0001733)1.82688212
143Abnormality of the nasolacrimal system (HP:0000614)1.82675880
144Arnold-Chiari malformation (HP:0002308)1.82381021
145Shallow orbits (HP:0000586)1.82036714
146Ileus (HP:0002595)1.81003590
147Ulnar bowing (HP:0003031)1.79409041
148Abnormality of the Achilles tendon (HP:0005109)1.79218898
149Diaphragmatic weakness (HP:0009113)1.78896849
150Respiratory distress (HP:0002098)1.77889025
151Aplasia/Hypoplasia of the sternum (HP:0006714)1.77777687
152Nasolacrimal duct obstruction (HP:0000579)1.77569784
153Nephroblastoma (Wilms tumor) (HP:0002667)1.77435403
154Abnormality of the preputium (HP:0100587)1.76955789
155Acanthocytosis (HP:0001927)1.76852809
156Long palpebral fissure (HP:0000637)1.74871295
157Hyperglycemia (HP:0003074)1.74485612
158Woolly hair (HP:0002224)1.74266115
159Abnormal lung lobation (HP:0002101)1.73671855
160Broad distal phalanx of finger (HP:0009836)1.72935909
161Coronal craniosynostosis (HP:0004440)1.72227652
162Natal tooth (HP:0000695)1.71975318
163Ependymoma (HP:0002888)1.71254281
164Hyperuricemia (HP:0002149)1.71115595
165Increased purine levels (HP:0004368)1.71115595
166Preauricular skin tag (HP:0000384)1.70927945
167Squamous cell carcinoma (HP:0002860)1.70790771
168Cellular immunodeficiency (HP:0005374)1.69893662
169Morphological abnormality of the inner ear (HP:0011390)1.68450193
170Advanced eruption of teeth (HP:0006288)1.68323029
171Abnormality of oral frenula (HP:0000190)1.67693065
172Peritonitis (HP:0002586)1.67647950
173Hypotrichosis (HP:0001006)1.67338299
174Maternal diabetes (HP:0009800)1.66420546
175Wide nose (HP:0000445)1.66398989
176Ridged nail (HP:0001807)1.66312803
177Congenital ichthyosiform erythroderma (HP:0007431)1.66124346
178Fragile skin (HP:0001030)1.66047410
179Abnormality of nail color (HP:0100643)1.65948032
180Alopecia of scalp (HP:0002293)1.65633600
181Metaphyseal cupping (HP:0003021)1.65577315
182Choanal atresia (HP:0000453)1.65473368
183Horseshoe kidney (HP:0000085)1.65437580
184Absent radius (HP:0003974)1.65222548
185Biconcave vertebral bodies (HP:0004586)1.64338325
186Systemic lupus erythematosus (HP:0002725)1.64206665
187Abnormality of reticulocytes (HP:0004312)1.64000979
188Pallor (HP:0000980)1.61412970
189Abnormal trabecular bone morphology (HP:0100671)1.59798149
190Ragged-red muscle fibers (HP:0003200)1.58056074
191Distal lower limb muscle weakness (HP:0009053)1.57655109
192Flared metaphyses (HP:0003015)1.56258994
193Breech presentation (HP:0001623)1.55842004
194Trigonocephaly (HP:0000243)1.55677872

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.16677000
2SIK14.29835203
3VRK23.55741710
4SMG13.35754576
5ERN13.25460381
6NME23.14866722
7FGFR43.13835709
8TRIB33.04410466
9BUB12.79698166
10TTK2.57849973
11EEF2K2.56562285
12CDC72.43064131
13STK392.33419998
14MET2.23818993
15EPHB12.21795154
16ERBB42.19329506
17TSSK62.17766102
18FGFR22.16712188
19NME12.04426535
20PAK42.03794650
21RPS6KB21.96746275
22MST1R1.95918849
23LMTK21.95484351
24LATS11.94158748
25ICK1.90894998
26MAPK151.82416303
27PKN21.82226936
28PASK1.73633516
29SRPK11.73332141
30INSRR1.73168737
31OXSR11.70709856
32PTK61.68037441
33DDR21.62276536
34WNK41.61629028
35EPHA41.53427085
36PAK31.42037825
37TAF11.39045508
38MST41.38823106
39EPHA21.37661956
40EPHB21.35214361
41CDK71.24822631
42PTK21.22836065
43NEK21.19241856
44CHEK21.15616233
45DYRK31.10639167
46MKNK11.08832926
47ATR1.07456443
48PDGFRA1.06471216
49ERBB21.05413480
50MAP3K71.04961232
51TTN1.04819720
52RIPK11.04074747
53TAOK31.03585890
54MAPKAPK31.02848255
55CSNK1A1L1.02757974
56MAP2K41.01776559
57MAPK111.00319167
58BMX0.99646378
59CAMK2G0.94561340
60PIK3CG0.94544148
61ABL20.93567285
62PHKG20.91835723
63PHKG10.91835723
64MAP3K90.91381480
65PKN10.91350544
66MAP2K20.89947688
67CSNK1G10.88796733
68CDK120.88720576
69NTRK10.88083228
70PLK30.87365398
71PBK0.86841354
72CSNK1G30.86349126
73PLK10.85629202
74PLK40.85315503
75BCR0.82829306
76PINK10.82665342
77PRKAA20.80831344
78PDPK10.79271945
79MUSK0.79064936
80PRKD10.78824482
81FER0.78201647
82DYRK1B0.77245295
83AURKB0.77218091
84STK160.76700218
85BRSK10.76633279
86ZAK0.75096194
87MAP3K60.72802806
88CDK40.72774903
89MAP2K10.72746382
90WEE10.72461046
91STK38L0.72183292
92LATS20.71869029
93DAPK20.71569813
94TAOK20.70945993
95MAP3K80.70722116
96MAP3K30.69618369
97EPHA30.69440153
98MAP3K20.69438957
99PAK60.69395280
100SCYL20.68789148
101CSNK1G20.68552816
102LRRK20.65683027
103KDR0.65168266
104FRK0.64412337
105ALK0.63543235
106CHEK10.63251700
107STK40.62458946
108FGFR10.62240360
109PRKCZ0.61447002
110CAMK2D0.60238549
111DAPK10.58417612
112MTOR0.58354280
113ROCK20.56218828
114DYRK20.56008209
115ROCK10.55844223
116GSK3A0.55814121
117PDK30.55640272
118PDK40.55640272
119PRKG20.55257689
120PRKAA10.53841227
121JAK20.53772768
122MAPK70.53247134
123RPS6KA20.53123371
124AKT20.53006288
125KSR20.52824984
126RPS6KC10.52594905
127RPS6KL10.52594905
128VRK10.52187668
129TESK10.52009084
130WNK10.51939454
131RPS6KA40.51226371
132PRKACG0.49956062
133CDK20.49545700
134MAPK120.47979405
135NEK90.47910947
136SIK30.47910039
137BRSK20.47902959
138RET0.47281196
139STK240.46956381
140PIK3CA0.46083417
141ILK0.46026119
142CDK10.45473053
143TGFBR10.44683939
144FLT30.44235375
145PRKCQ0.44054955
146PRKD20.43597494
147ATM0.42961091
148AURKA0.42562357
149EIF2AK20.42505372
150TESK20.42467920
151GRK60.42275674
152MAP3K100.41900609
153MAP3K10.41586638
154CDK60.40593837
155PRKCI0.40531838
156RPS6KA10.39873078
157TYRO30.39608232
158SGK4940.39306437
159SGK2230.39306437
160PRPF4B0.38933867
161CDC42BPA0.38862156
162PAK20.38705324
163IRAK20.37596568
164CDK80.37462377
165PDGFRB0.36982672
166CAMK2B0.36918046
167TNIK0.36885126
168CDK190.35661819
169ARAF0.34773102
170PAK10.33843296
171MAPK40.31328044
172IRAK30.30514311
173PRKCH0.29554987
174CAMK2A0.29404638

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.83314777
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.97830858
3Mismatch repair_Homo sapiens_hsa034303.81603524
4Nitrogen metabolism_Homo sapiens_hsa009103.60702656
5Base excision repair_Homo sapiens_hsa034103.40863470
6Ribosome_Homo sapiens_hsa030103.37251643
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.02914249
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99150363
9Spliceosome_Homo sapiens_hsa030402.81289941
10Non-homologous end-joining_Homo sapiens_hsa034502.81273455
11Arginine biosynthesis_Homo sapiens_hsa002202.80392468
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70015194
13Fatty acid degradation_Homo sapiens_hsa000712.67083219
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53422685
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52637464
16Proteasome_Homo sapiens_hsa030502.51564283
17Tryptophan metabolism_Homo sapiens_hsa003802.51095655
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50662406
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47705109
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47529837
21Homologous recombination_Homo sapiens_hsa034402.43249852
22Butanoate metabolism_Homo sapiens_hsa006502.33888779
23Complement and coagulation cascades_Homo sapiens_hsa046102.25126183
24Cell cycle_Homo sapiens_hsa041102.18703172
25Nucleotide excision repair_Homo sapiens_hsa034202.13396052
26Fatty acid metabolism_Homo sapiens_hsa012122.10477267
27Propanoate metabolism_Homo sapiens_hsa006402.06155241
28RNA transport_Homo sapiens_hsa030132.05881530
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03149782
30Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02637609
31Peroxisome_Homo sapiens_hsa041461.99409574
32PPAR signaling pathway_Homo sapiens_hsa033201.93890335
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88625109
34Histidine metabolism_Homo sapiens_hsa003401.85658515
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80572030
36Chemical carcinogenesis_Homo sapiens_hsa052041.79912261
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.78579707
38Fatty acid elongation_Homo sapiens_hsa000621.72131427
39Sulfur metabolism_Homo sapiens_hsa009201.69119073
40Steroid biosynthesis_Homo sapiens_hsa001001.67854843
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67053807
42Thyroid cancer_Homo sapiens_hsa052161.63916208
43RNA polymerase_Homo sapiens_hsa030201.63713865
44beta-Alanine metabolism_Homo sapiens_hsa004101.62977386
45mRNA surveillance pathway_Homo sapiens_hsa030151.60733750
46Bile secretion_Homo sapiens_hsa049761.59292146
47Notch signaling pathway_Homo sapiens_hsa043301.57463649
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56961519
49Caffeine metabolism_Homo sapiens_hsa002321.53920115
50Pyrimidine metabolism_Homo sapiens_hsa002401.53809888
51Retinol metabolism_Homo sapiens_hsa008301.50805338
52Fanconi anemia pathway_Homo sapiens_hsa034601.48572173
53Fat digestion and absorption_Homo sapiens_hsa049751.41358182
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40351363
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.39979648
56Phenylalanine metabolism_Homo sapiens_hsa003601.38643053
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37596234
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.35385542
59Folate biosynthesis_Homo sapiens_hsa007901.35102215
60Tyrosine metabolism_Homo sapiens_hsa003501.34712511
61Pyruvate metabolism_Homo sapiens_hsa006201.34621374
62Selenocompound metabolism_Homo sapiens_hsa004501.26276549
63Adherens junction_Homo sapiens_hsa045201.25504563
64Starch and sucrose metabolism_Homo sapiens_hsa005001.25350020
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.19063981
66Arginine and proline metabolism_Homo sapiens_hsa003301.18120458
67Carbon metabolism_Homo sapiens_hsa012001.17728013
68Staphylococcus aureus infection_Homo sapiens_hsa051501.15993195
69Biosynthesis of amino acids_Homo sapiens_hsa012301.15143400
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10975232
71ABC transporters_Homo sapiens_hsa020101.05920904
72Maturity onset diabetes of the young_Homo sapiens_hsa049501.03912919
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03394062
74MicroRNAs in cancer_Homo sapiens_hsa052060.98920085
75Hippo signaling pathway_Homo sapiens_hsa043900.98227119
76Vitamin digestion and absorption_Homo sapiens_hsa049770.97160805
77Sulfur relay system_Homo sapiens_hsa041220.96766880
78Vitamin B6 metabolism_Homo sapiens_hsa007500.95790825
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.93920423
80p53 signaling pathway_Homo sapiens_hsa041150.92981537
81Fatty acid biosynthesis_Homo sapiens_hsa000610.92200240
82RNA degradation_Homo sapiens_hsa030180.84250962
83Chronic myeloid leukemia_Homo sapiens_hsa052200.82252601
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82120928
85Wnt signaling pathway_Homo sapiens_hsa043100.81255400
86Glutathione metabolism_Homo sapiens_hsa004800.80605384
87Lysine degradation_Homo sapiens_hsa003100.78754280
88Prostate cancer_Homo sapiens_hsa052150.78166437
89N-Glycan biosynthesis_Homo sapiens_hsa005100.77933466
90Acute myeloid leukemia_Homo sapiens_hsa052210.77088660
91Glycerolipid metabolism_Homo sapiens_hsa005610.76567631
92Basal transcription factors_Homo sapiens_hsa030220.75522407
93Purine metabolism_Homo sapiens_hsa002300.75052841
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73499587
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72559555
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72077287
97Endometrial cancer_Homo sapiens_hsa052130.70445474
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67974546
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66767439
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65948198
101Colorectal cancer_Homo sapiens_hsa052100.64685516
102Small cell lung cancer_Homo sapiens_hsa052220.61137753
103HTLV-I infection_Homo sapiens_hsa051660.60248716
104Epstein-Barr virus infection_Homo sapiens_hsa051690.60177010
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59616607
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53992742
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51628369
108Other glycan degradation_Homo sapiens_hsa005110.50041150
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48859804
110Herpes simplex infection_Homo sapiens_hsa051680.48857761
111Pentose phosphate pathway_Homo sapiens_hsa000300.48443689
112Pathways in cancer_Homo sapiens_hsa052000.48093410
113Proteoglycans in cancer_Homo sapiens_hsa052050.47670477
114Viral carcinogenesis_Homo sapiens_hsa052030.47433053
115Huntingtons disease_Homo sapiens_hsa050160.47404094
116Metabolic pathways_Homo sapiens_hsa011000.47181772
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41725490
118Pancreatic cancer_Homo sapiens_hsa052120.41320463
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40685052
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38412008
121Linoleic acid metabolism_Homo sapiens_hsa005910.37917063
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.37769318
123Apoptosis_Homo sapiens_hsa042100.34934678
124Melanogenesis_Homo sapiens_hsa049160.34870397
125Oocyte meiosis_Homo sapiens_hsa041140.33887438
126Prion diseases_Homo sapiens_hsa050200.32124906
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.32038517
128VEGF signaling pathway_Homo sapiens_hsa043700.31829504
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.30012565
130Protein digestion and absorption_Homo sapiens_hsa049740.29524908
131Insulin resistance_Homo sapiens_hsa049310.28651653
132Galactose metabolism_Homo sapiens_hsa000520.28638793
133Hepatitis C_Homo sapiens_hsa051600.28580533
134Fructose and mannose metabolism_Homo sapiens_hsa000510.28512807
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25437994
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24027952
137Focal adhesion_Homo sapiens_hsa045100.23588276
138Non-small cell lung cancer_Homo sapiens_hsa052230.23134767
139TGF-beta signaling pathway_Homo sapiens_hsa043500.22805640
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21176563
141Melanoma_Homo sapiens_hsa052180.20081491
142One carbon pool by folate_Homo sapiens_hsa006700.16329817
143ECM-receptor interaction_Homo sapiens_hsa045120.15123683
144Ovarian steroidogenesis_Homo sapiens_hsa049130.10158744
145Ether lipid metabolism_Homo sapiens_hsa005650.09523485
146AMPK signaling pathway_Homo sapiens_hsa041520.07112411
147Mineral absorption_Homo sapiens_hsa049780.06962804
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.06150355
149Glucagon signaling pathway_Homo sapiens_hsa049220.05645082
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04815330
151Bladder cancer_Homo sapiens_hsa052190.03181432
152Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1183765
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1085127
154Hedgehog signaling pathway_Homo sapiens_hsa04340-0.1080860
155Tight junction_Homo sapiens_hsa04530-0.1032497
156Pancreatic secretion_Homo sapiens_hsa04972-0.0980808
157Renin-angiotensin system_Homo sapiens_hsa04614-0.0950296
158Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0892809
159Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0861398
160Insulin signaling pathway_Homo sapiens_hsa04910-0.0792414
161Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0425267
162Amoebiasis_Homo sapiens_hsa05146-0.0236903
163Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0159663
164Basal cell carcinoma_Homo sapiens_hsa05217-0.0063123

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