ARHGEF18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.96805755
2regulation of gamma-delta T cell differentiation (GO:0045586)5.95325073
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.90287207
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.90287207
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.34244544
6negative regulation of cell killing (GO:0031342)5.34244544
7antigen processing and presentation of endogenous antigen (GO:0019883)5.33631685
8glomerular visceral epithelial cell development (GO:0072015)5.25301144
9regulation of gamma-delta T cell activation (GO:0046643)5.16696113
10positive thymic T cell selection (GO:0045059)4.92869580
11positive regulation of histone deacetylation (GO:0031065)4.89983969
12negative T cell selection (GO:0043383)4.63030378
13glomerular epithelial cell development (GO:0072310)4.60149434
14thymic T cell selection (GO:0045061)4.50929856
15negative thymic T cell selection (GO:0045060)4.47868076
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.38533199
17positive T cell selection (GO:0043368)4.28407297
18T cell selection (GO:0045058)4.22854657
19detection of bacterium (GO:0016045)4.17917161
20positive regulation by symbiont of host defense response (GO:0052509)4.17480406
21modulation by symbiont of host defense response (GO:0052031)4.17480406
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.17480406
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.17480406
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.17480406
25modulation by symbiont of host immune response (GO:0052553)4.17480406
26detection of other organism (GO:0098543)4.16048779
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.89001103
28response to interleukin-15 (GO:0070672)3.82802549
29B cell receptor signaling pathway (GO:0050853)3.82378701
30interferon-gamma production (GO:0032609)3.82342532
31negative regulation of histone methylation (GO:0031061)3.70468497
32pre-miRNA processing (GO:0031054)3.67414075
33regulation of B cell differentiation (GO:0045577)3.64832110
34glomerular basement membrane development (GO:0032836)3.63783071
35positive regulation of protein deacetylation (GO:0090312)3.62325974
36natural killer cell differentiation (GO:0001779)3.58148171
37macrophage activation involved in immune response (GO:0002281)3.55086334
38regulation of interleukin-12 biosynthetic process (GO:0045075)3.52651660
39response to muramyl dipeptide (GO:0032495)3.52179648
40negative regulation of erythrocyte differentiation (GO:0045647)3.45559300
41detection of external biotic stimulus (GO:0098581)3.37342857
42antigen processing and presentation via MHC class Ib (GO:0002475)3.36048426
43response to peptidoglycan (GO:0032494)3.28792408
44neutrophil activation involved in immune response (GO:0002283)3.25363160
45T cell receptor signaling pathway (GO:0050852)3.23733077
46mannose metabolic process (GO:0006013)3.22779238
47tolerance induction (GO:0002507)3.21416856
48NIK/NF-kappaB signaling (GO:0038061)3.18403237
49regulation of interferon-beta biosynthetic process (GO:0045357)3.17962782
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.17323415
51positive regulation of B cell differentiation (GO:0045579)3.16226256
52regulation of B cell receptor signaling pathway (GO:0050855)3.15077130
53antigen receptor-mediated signaling pathway (GO:0050851)3.14969399
54T cell costimulation (GO:0031295)3.11633760
55T cell migration (GO:0072678)3.11109592
56lymphocyte costimulation (GO:0031294)3.02521892
57negative regulation of leukocyte mediated immunity (GO:0002704)3.01558865
58regulation of leukocyte degranulation (GO:0043300)3.00733852
59nuclear pore complex assembly (GO:0051292)3.00679905
60positive regulation of Cdc42 GTPase activity (GO:0043089)3.00456025
61hepatocyte apoptotic process (GO:0097284)2.98668532
62negative regulation of toll-like receptor signaling pathway (GO:0034122)2.97838972
63regulation of isotype switching to IgG isotypes (GO:0048302)2.94080070
64cellular extravasation (GO:0045123)2.93713765
65cellular response to interleukin-15 (GO:0071350)2.92973448
66response to laminar fluid shear stress (GO:0034616)2.92334623
67germinal center formation (GO:0002467)2.92030348
68respiratory burst (GO:0045730)2.90617234
69detection of biotic stimulus (GO:0009595)2.90374820
70immunoglobulin mediated immune response (GO:0016064)2.88879417
71positive regulation of Rap GTPase activity (GO:0032854)2.88803177
72regulation of histone H3-K27 methylation (GO:0061085)2.88567627
73response to type I interferon (GO:0034340)2.86438403
74type I interferon signaling pathway (GO:0060337)2.86284314
75cellular response to type I interferon (GO:0071357)2.86284314
76histone H3-K36 demethylation (GO:0070544)2.85268716
77regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84611346
78signal complex assembly (GO:0007172)2.83613553
79megakaryocyte development (GO:0035855)2.81781369
80negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78040152
81regulation of extracellular matrix disassembly (GO:0010715)2.76613649
82regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.74362876
83regulation of dendritic cell antigen processing and presentation (GO:0002604)2.73060197
84dosage compensation (GO:0007549)2.72660835
85response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72162939
86response to host (GO:0075136)2.72162939
87response to host defenses (GO:0052200)2.72162939
88regulation of mast cell degranulation (GO:0043304)2.71999472
89positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71936840
90negative regulation of T cell mediated immunity (GO:0002710)2.71570274
91detection of molecule of bacterial origin (GO:0032490)2.70977974
92regulation of response to interferon-gamma (GO:0060330)2.70944799
93regulation of tolerance induction (GO:0002643)2.70081734
94endothelial cell chemotaxis (GO:0035767)2.70064989
95regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.68894475
96negative regulation of phagocytosis (GO:0050765)2.68872246
97negative regulation of interleukin-12 production (GO:0032695)2.67714392
98negative regulation of stress fiber assembly (GO:0051497)2.67510934
99regulation of necroptotic process (GO:0060544)2.66949034
100response to host immune response (GO:0052572)2.64867426
101response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.64867426
102regulation of defense response to virus by virus (GO:0050690)2.64633332
103positive regulation of cell adhesion mediated by integrin (GO:0033630)2.63689848
104negative regulation of innate immune response (GO:0045824)2.63138822
105modulation by symbiont of host cellular process (GO:0044068)2.61479532
106regulation of T-helper 2 cell differentiation (GO:0045628)2.61120846
107leukocyte aggregation (GO:0070486)2.59768864
108myeloid cell activation involved in immune response (GO:0002275)2.58702971
109determination of adult lifespan (GO:0008340)2.58439124
110modulation by virus of host process (GO:0019054)2.57623538
111regulation of T cell tolerance induction (GO:0002664)2.57512411
112negative regulation of glycoprotein biosynthetic process (GO:0010561)2.56545650
113histone H4-K16 acetylation (GO:0043984)2.56418491
114morphogenesis of an endothelium (GO:0003159)2.55794388
115endothelial tube morphogenesis (GO:0061154)2.55794388
116definitive hemopoiesis (GO:0060216)2.55653565
117histone H3-K4 methylation (GO:0051568)2.55631890
1183-UTR-mediated mRNA stabilization (GO:0070935)2.54783488
119positive regulation of tolerance induction (GO:0002645)2.53765647
120regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53510011
121nuclear pore organization (GO:0006999)2.52911977
122mitotic G1 DNA damage checkpoint (GO:0031571)2.52684714
123negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.51973408
124regulation of histone H3-K9 methylation (GO:0051570)2.51851028
125glucocorticoid receptor signaling pathway (GO:0042921)2.50645639
126negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.50246338
127neutrophil activation (GO:0042119)2.50084967
128embryonic process involved in female pregnancy (GO:0060136)2.50053635
129regulation of regulated secretory pathway (GO:1903305)2.49884483
130regulation of translational fidelity (GO:0006450)2.48494932
131regulation of T cell receptor signaling pathway (GO:0050856)2.47886285
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.47754950
133regulation of histone deacetylation (GO:0031063)2.46941494
134peptidyl-lysine dimethylation (GO:0018027)2.46769886
135defense response to protozoan (GO:0042832)2.46517517
136immune response-activating cell surface receptor signaling pathway (GO:0002429)2.45407255
137regulation of natural killer cell mediated immunity (GO:0002715)2.45338111
138regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.45338111
139heterochromatin organization (GO:0070828)2.45240116
140interferon-gamma-mediated signaling pathway (GO:0060333)2.45014321
141regulation of RNA export from nucleus (GO:0046831)2.44619640
142trophectodermal cell differentiation (GO:0001829)2.44017098
143activation of JUN kinase activity (GO:0007257)2.43929805
144cytoplasmic mRNA processing body assembly (GO:0033962)2.43766511
145B cell homeostasis (GO:0001782)2.43310946
146JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.42958702
147T cell homeostasis (GO:0043029)2.41946093
148DNA duplex unwinding (GO:0032508)2.41764633
149angiogenesis involved in wound healing (GO:0060055)2.41661656
150cellular response to virus (GO:0098586)2.41572654
151positive regulation of gene expression, epigenetic (GO:0045815)2.41434614
152V(D)J recombination (GO:0033151)2.41183859
153alternative mRNA splicing, via spliceosome (GO:0000380)2.39968487
154protein localization to endosome (GO:0036010)2.39882495
155adherens junction assembly (GO:0034333)2.39858480
156regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.39270431
157histone H3-K4 trimethylation (GO:0080182)2.38086264
158DNA geometric change (GO:0032392)2.37917417
159leukocyte cell-cell adhesion (GO:0007159)2.37553423
160positive regulation of lamellipodium assembly (GO:0010592)2.37503610
161vascular endothelial growth factor signaling pathway (GO:0038084)2.37098562
162cellular hyperosmotic response (GO:0071474)2.36994922
163cell-substrate adherens junction assembly (GO:0007045)2.35634496
164focal adhesion assembly (GO:0048041)2.35634496
165embryonic placenta development (GO:0001892)2.32075172
166negative regulation of bone resorption (GO:0045779)2.31769017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.70409380
2MYC_22102868_ChIP-Seq_BL_Human4.39061660
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.14443388
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88491584
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.26075360
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.19345820
7VDR_21846776_ChIP-Seq_THP-1_Human2.91440253
8TCF7_22412390_ChIP-Seq_EML_Mouse2.68110120
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.51943396
10KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.48426657
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.44892487
12MAF_26560356_Chip-Seq_TH1_Human2.41229295
13UTX_26944678_Chip-Seq_JUKART_Human2.39295019
14RUNX_20019798_ChIP-Seq_JUKART_Human2.39149498
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.38644726
16KDM2B_26808549_Chip-Seq_DND41_Human2.38017723
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.34303067
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.32964162
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.32216718
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22812571
21MYB_26560356_Chip-Seq_TH2_Human2.12519168
22MYB_26560356_Chip-Seq_TH1_Human2.10353293
23* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08992968
24SCL_19346495_ChIP-Seq_HPC-7_Human2.02040436
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89652352
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.86286624
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81112565
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75885876
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.71901541
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71744548
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70274136
32CIITA_25753668_ChIP-Seq_RAJI_Human1.69125428
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68510668
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63253018
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61806602
36VDR_24763502_ChIP-Seq_THP-1_Human1.60916925
37* RUNX1_22412390_ChIP-Seq_EML_Mouse1.60627246
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60154474
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60037726
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.59782841
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.58120845
42MAF_26560356_Chip-Seq_TH2_Human1.52764847
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51774992
44LXR_22292898_ChIP-Seq_THP-1_Human1.48345190
45NCOR1_26117541_ChIP-Seq_K562_Human1.48186246
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42207338
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40105495
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.36757725
49PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34754414
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34404661
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33273164
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31734397
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31173400
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30990797
55SPI1_23127762_ChIP-Seq_K562_Human1.28072391
56* BCOR_27268052_Chip-Seq_Bcells_Human1.27777664
57CLOCK_20551151_ChIP-Seq_293T_Human1.27457911
58CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26287815
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25838249
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23986086
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23879809
62GATA3_27048872_Chip-Seq_THYMUS_Human1.23730570
63* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22644112
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21932717
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21697338
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19414374
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18953758
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18848279
69SMC4_20622854_ChIP-Seq_HELA_Human1.18704377
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18294682
71* TET1_21451524_ChIP-Seq_MESCs_Mouse1.17691905
72RACK7_27058665_Chip-Seq_MCF-7_Human1.17508500
73* BCL6_27268052_Chip-Seq_Bcells_Human1.16052686
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15482954
75SPI1_23547873_ChIP-Seq_NB4_Human1.14657002
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14427635
77* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14224066
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13766347
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13339263
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11869067
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10864781
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09102417
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09047971
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07956876
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07173173
86* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07129438
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06626819
88CREB1_26743006_Chip-Seq_LNCaP_Human1.06089592
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05695848
90ZNF263_19887448_ChIP-Seq_K562_Human1.05590215
91* FOXO3_23340844_ChIP-Seq_DLD1_Human1.05053405
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05024727
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04775701
94* ELF1_20517297_ChIP-Seq_JURKAT_Human1.04464926
95SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04074095
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02857140
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01635172
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00554900
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00387480
100GATA1_19941826_ChIP-Seq_K562_Human1.00255995
101KDM2B_26808549_Chip-Seq_K562_Human0.99976473
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99462659
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.98368261
104DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97266810
105SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96120706
106E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95862722
107* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95845740
108IRF8_27001747_Chip-Seq_BMDM_Mouse0.95455624
109* RUNX1_27514584_Chip-Seq_MCF-7_Human0.95324879
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94358245
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94050102
112ETS1_21867929_ChIP-Seq_TH2_Mouse0.93408015
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93170011
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.93135583
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92984122
116ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92555864
117GATA1_22025678_ChIP-Seq_K562_Human0.91550897
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91345421
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91216490
120* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90075291
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89102779
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88491692
123NOTCH1_21737748_ChIP-Seq_TLL_Human0.88015893
124ATF3_27146783_Chip-Seq_COLON_Human0.87303668
125* P68_20966046_ChIP-Seq_HELA_Human0.86114534
126GATA2_19941826_ChIP-Seq_K562_Human0.85906970
127* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85290586
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84838579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.62528040
2MP0002396_abnormal_hematopoietic_system3.24146809
3MP0010352_gastrointestinal_tract_polyps2.81516587
4MP0003300_gastrointestinal_ulcer2.63296830
5MP0003724_increased_susceptibility_to2.60225197
6MP0002166_altered_tumor_susceptibility2.55844798
7MP0008260_abnormal_autophagy2.51111427
8MP0000685_abnormal_immune_system2.45839280
9MP0001800_abnormal_humoral_immune2.41510490
10MP0004808_abnormal_hematopoietic_stem2.40546016
11MP0005451_abnormal_body_composition2.40298552
12MP0001873_stomach_inflammation2.36354918
13MP0002398_abnormal_bone_marrow2.31830049
14MP0008961_abnormal_basal_metabolism2.22536141
15MP0005671_abnormal_response_to2.15234127
16MP0010234_abnormal_vibrissa_follicle2.14420791
17MP0003705_abnormal_hypodermis_morpholog2.06637726
18MP0005387_immune_system_phenotype2.06526959
19MP0001790_abnormal_immune_system2.06526959
20MP0000703_abnormal_thymus_morphology2.05678392
21MP0001835_abnormal_antigen_presentation2.04115360
22MP0009278_abnormal_bone_marrow2.01461816
23MP0003566_abnormal_cell_adhesion2.01296567
24MP0000689_abnormal_spleen_morphology1.99763233
25MP0003172_abnormal_lysosome_physiology1.99724550
26MP0009840_abnormal_foam_cell1.95200126
27MP0005058_abnormal_lysosome_morphology1.94719043
28MP0002722_abnormal_immune_system1.93563974
29MP0002420_abnormal_adaptive_immunity1.90182787
30MP0000716_abnormal_immune_system1.86104414
31MP0005397_hematopoietic_system_phenotyp1.84209373
32MP0001545_abnormal_hematopoietic_system1.84209373
33MP0001819_abnormal_immune_cell1.83877224
34MP0002006_tumorigenesis1.83745331
35MP0003303_peritoneal_inflammation1.82035315
36MP0002452_abnormal_antigen_presenting1.76547892
37MP0005464_abnormal_platelet_physiology1.70736363
38MP0009785_altered_susceptibility_to1.67991945
39MP0002723_abnormal_immune_serum1.66373904
40MP0002429_abnormal_blood_cell1.64641574
41MP0006082_CNS_inflammation1.64112855
42MP0001533_abnormal_skeleton_physiology1.63764903
43MP0004947_skin_inflammation1.63331838
44MP0003866_abnormal_defecation1.62323383
45MP0010155_abnormal_intestine_physiology1.58630052
46MP0005076_abnormal_cell_differentiation1.55373711
47MP0004381_abnormal_hair_follicle1.54497721
48MP0005023_abnormal_wound_healing1.49619351
49MP0005409_darkened_coat_color1.44309767
50MP0009333_abnormal_splenocyte_physiolog1.43994743
51MP0002148_abnormal_hypersensitivity_rea1.42714423
52MP0010307_abnormal_tumor_latency1.42333351
53MP0002405_respiratory_system_inflammati1.36376318
54MP0003091_abnormal_cell_migration1.35364940
55MP0005000_abnormal_immune_tolerance1.35277829
56MP0000858_altered_metastatic_potential1.32991686
57MP0003045_fibrosis1.31542165
58MP0000490_abnormal_crypts_of1.30114750
59MP0002998_abnormal_bone_remodeling1.28939611
60MP0004264_abnormal_extraembryonic_tissu1.28021651
61MP0001851_eye_inflammation1.26822920
62MP0003077_abnormal_cell_cycle1.25979904
63MP0004185_abnormal_adipocyte_glucose1.25926852
64MP0008057_abnormal_DNA_replication1.25338018
65MP0002019_abnormal_tumor_incidence1.24298101
66MP0002136_abnormal_kidney_physiology1.22962125
67MP0006054_spinal_hemorrhage1.22320799
68MP0003828_pulmonary_edema1.21383876
69MP0002086_abnormal_extraembryonic_tissu1.21382198
70MP0002009_preneoplasia1.14766225
71MP0005310_abnormal_salivary_gland1.12450724
72MP0003436_decreased_susceptibility_to1.12373613
73MP0001348_abnormal_lacrimal_gland1.11971961
74MP0001845_abnormal_inflammatory_respons1.10874666
75MP0005025_abnormal_response_to1.10351875
76MP0001730_embryonic_growth_arrest1.09281395
77MP0004858_abnormal_nervous_system1.08911029
78MP0000465_gastrointestinal_hemorrhage1.08556369
79MP0008469_abnormal_protein_level1.08160733
80MP0002796_impaired_skin_barrier1.07271640
81MP0003111_abnormal_nucleus_morphology1.06665066
82MP0003279_aneurysm1.05274459
83MP0000477_abnormal_intestine_morphology1.04926373
84MP0003183_abnormal_peptide_metabolism1.04713630
85MP0004510_myositis1.03917878
86MP0003329_amyloid_beta_deposits1.03880578
87MP0000350_abnormal_cell_proliferation1.02950847
88MP0001958_emphysema1.01494112
89MP0010094_abnormal_chromosome_stability1.00143381
90MP0004957_abnormal_blastocyst_morpholog0.98981410
91MP0003448_altered_tumor_morphology0.98102518
92MP0000604_amyloidosis0.96555787
93MP0003984_embryonic_growth_retardation0.94940913
94MP0002088_abnormal_embryonic_growth/wei0.93517523
95MP0005670_abnormal_white_adipose0.93420390
96MP0002132_abnormal_respiratory_system0.92846867
97MP0005666_abnormal_adipose_tissue0.92201893
98MP0005166_decreased_susceptibility_to0.92196729
99MP0001661_extended_life_span0.91761719
100MP0004197_abnormal_fetal_growth/weight/0.91550233
101MP0002933_joint_inflammation0.91422549
102MP0000609_abnormal_liver_physiology0.90685406
103MP0005380_embryogenesis_phenotype0.90420351
104MP0001672_abnormal_embryogenesis/_devel0.90420351
105MP0000569_abnormal_digit_pigmentation0.90187773
106MP0002084_abnormal_developmental_patter0.90045081
107MP0009643_abnormal_urine_homeostasis0.89987463
108MP0002925_abnormal_cardiovascular_devel0.89301592
109MP0005623_abnormal_meninges_morphology0.88600650
110MP0008770_decreased_survivor_rate0.88118802
111MP0001849_ear_inflammation0.88006717
112MP0002135_abnormal_kidney_morphology0.87628005
113MP0001663_abnormal_digestive_system0.85278089
114MP0003191_abnormal_cellular_cholesterol0.84736950
115MP0001915_intracranial_hemorrhage0.83941852
116MP0005501_abnormal_skin_physiology0.83451460
117MP0002877_abnormal_melanocyte_morpholog0.83221649
118MP0004883_abnormal_blood_vessel0.81648014
119MP0001853_heart_inflammation0.80602599
120MP0001697_abnormal_embryo_size0.78875092
121MP0002080_prenatal_lethality0.78804492
122MP0005375_adipose_tissue_phenotype0.78544280
123MP0003787_abnormal_imprinting0.78458301
124MP0003453_abnormal_keratinocyte_physiol0.78321919
125MP0002928_abnormal_bile_duct0.78293204
126MP0003075_altered_response_to0.77952792
127MP0001784_abnormal_fluid_regulation0.76261935
128MP0004130_abnormal_muscle_cell0.76045996
129MP0005621_abnormal_cell_physiology0.75661363
130MP0000015_abnormal_ear_pigmentation0.75609809
131MP0002419_abnormal_innate_immunity0.75353859
132MP0005390_skeleton_phenotype0.73230791
133MP0000598_abnormal_liver_morphology0.72525965
134MP0002138_abnormal_hepatobiliary_system0.71509054
135MP0005365_abnormal_bile_salt0.70974487
136MP0008874_decreased_physiological_sensi0.70480485
137MP0000537_abnormal_urethra_morphology0.70125245
138MP0000249_abnormal_blood_vessel0.69856961
139MP0001216_abnormal_epidermal_layer0.68768555
140MP0009931_abnormal_skin_appearance0.68246419

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.48794775
2Abnormality of the fingertips (HP:0001211)4.22112584
3Recurrent bacterial skin infections (HP:0005406)3.97032430
4Recurrent abscess formation (HP:0002722)3.92751746
5T lymphocytopenia (HP:0005403)3.87058045
6Abnormality of macrophages (HP:0004311)3.80395615
7Recurrent bronchitis (HP:0002837)3.67849318
8Abnormality of T cell number (HP:0011839)3.52287174
9Myositis (HP:0100614)3.30740687
10Agammaglobulinemia (HP:0004432)3.20495738
11Recurrent viral infections (HP:0004429)3.19327979
12Mesangial abnormality (HP:0001966)3.18068365
13Chronic otitis media (HP:0000389)3.17284718
14Papilloma (HP:0012740)3.16649764
15Verrucae (HP:0200043)3.16649764
16IgM deficiency (HP:0002850)3.14952194
17Cerebral aneurysm (HP:0004944)3.03705488
18Recurrent gram-negative bacterial infections (HP:0005420)3.03619402
19Mediastinal lymphadenopathy (HP:0100721)2.99843727
20Gastrointestinal infarctions (HP:0005244)2.95681225
21Elevated erythrocyte sedimentation rate (HP:0003565)2.95064959
22Gingivitis (HP:0000230)2.88592110
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.87464771
24Abnormality of T cells (HP:0002843)2.87236533
25Gastrointestinal inflammation (HP:0004386)2.85496400
26Basal cell carcinoma (HP:0002671)2.85114325
27Orchitis (HP:0100796)2.84173409
28Hyperacusis (HP:0010780)2.83265679
29Inflammation of the large intestine (HP:0002037)2.81426599
30Aortic aneurysm (HP:0004942)2.80697138
31Panhypogammaglobulinemia (HP:0003139)2.79240300
32Obstructive lung disease (HP:0006536)2.78495554
33Chronic obstructive pulmonary disease (HP:0006510)2.78495554
34Colitis (HP:0002583)2.77748598
35Cellulitis (HP:0100658)2.73522514
36Nasal polyposis (HP:0100582)2.72424882
37Pustule (HP:0200039)2.72216654
38Focal segmental glomerulosclerosis (HP:0000097)2.68314775
39Autoimmune thrombocytopenia (HP:0001973)2.67479777
40Hemorrhage of the eye (HP:0011885)2.67235869
41Abnormality of the nasal mucosa (HP:0000433)2.64129611
42Recurrent skin infections (HP:0001581)2.62923744
43Abnormal platelet volume (HP:0011876)2.57315285
44Thin bony cortex (HP:0002753)2.57150545
45Broad face (HP:0000283)2.53729939
46Vasculitis (HP:0002633)2.45774345
47Lymphopenia (HP:0001888)2.43875328
48Recurrent fungal infections (HP:0002841)2.37284858
49Malnutrition (HP:0004395)2.35270035
50Abnormality of oral frenula (HP:0000190)2.34129071
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.33420881
52Spontaneous hematomas (HP:0007420)2.33378861
53Macroorchidism (HP:0000053)2.33378472
54Increased mean platelet volume (HP:0011877)2.33169155
55Osteomyelitis (HP:0002754)2.33160849
56Ulnar bowing (HP:0003031)2.29506775
57Retrobulbar optic neuritis (HP:0100654)2.26568486
58Optic neuritis (HP:0100653)2.26568486
59Urticaria (HP:0001025)2.24190988
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23075997
61Heterotopia (HP:0002282)2.20999361
62Glomerulosclerosis (HP:0000096)2.20391334
63Combined immunodeficiency (HP:0005387)2.20388253
64Stomatitis (HP:0010280)2.20139781
65Vertebral arch anomaly (HP:0008438)2.19442947
66Abnormal albumin level (HP:0012116)2.18404208
67Hypoalbuminemia (HP:0003073)2.18404208
68Slow saccadic eye movements (HP:0000514)2.17121137
69Ependymoma (HP:0002888)2.14431595
70Prolonged bleeding time (HP:0003010)2.12563202
71Thrombocytosis (HP:0001894)2.09448777
72Polygenic inheritance (HP:0010982)2.06633357
73Thyroiditis (HP:0100646)2.04626009
74Subacute progressive viral hepatitis (HP:0006572)2.03940470
75Encephalitis (HP:0002383)2.03606005
76Emphysema (HP:0002097)2.02984091
77Hematochezia (HP:0002573)2.01018788
78Broad palm (HP:0001169)2.00957540
79Aneurysm (HP:0002617)2.00519493
80Segmental peripheral demyelination/remyelination (HP:0003481)1.99784391
81Interstitial pulmonary disease (HP:0006530)1.98774260
82Obstructive sleep apnea (HP:0002870)1.98606696
83Flat acetabular roof (HP:0003180)1.97829097
84Abnormality of T cell physiology (HP:0011840)1.96344009
85Sepsis (HP:0100806)1.95095152
86Bronchitis (HP:0012387)1.93983602
87Mitral valve prolapse (HP:0001634)1.93587645
88Skin ulcer (HP:0200042)1.92388811
89Papilledema (HP:0001085)1.91837046
90Increased density of long bones (HP:0006392)1.90146045
91Gastrointestinal stroma tumor (HP:0100723)1.89675914
92Abnormality of the lower motor neuron (HP:0002366)1.89470236
93Granulocytopenia (HP:0001913)1.89321604
94Restrictive lung disease (HP:0002091)1.88129037
95Short 4th metacarpal (HP:0010044)1.87131770
96Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87131770
97Amyloidosis (HP:0011034)1.86559142
98Severe combined immunodeficiency (HP:0004430)1.86469830
99Meningitis (HP:0001287)1.85958778
100Long eyelashes (HP:0000527)1.85714335
101Hypochromic anemia (HP:0001931)1.84375116
102Pulmonary infiltrates (HP:0002113)1.84152860
103Petechiae (HP:0000967)1.83647383
104Gingival bleeding (HP:0000225)1.83108698
105Abnormal foot bone ossification (HP:0010675)1.83071756
106Dysostosis multiplex (HP:0000943)1.81015754
107Hypoplasia of the thymus (HP:0000778)1.79408855
108Premature loss of primary teeth (HP:0006323)1.78937047
109Ankle contracture (HP:0006466)1.78502553
110Persistence of primary teeth (HP:0006335)1.78040579
111Distal lower limb amyotrophy (HP:0008944)1.77452780
112Dilatation of the ascending aorta (HP:0005111)1.77149655
113Volvulus (HP:0002580)1.77084877
114Poikiloderma (HP:0001029)1.76871584
115Recurrent sinusitis (HP:0011108)1.75756167
116Peritonitis (HP:0002586)1.75128985
117Increased cerebral lipofuscin (HP:0011813)1.75092492
118Ureteral stenosis (HP:0000071)1.74435125
119Selective tooth agenesis (HP:0001592)1.74256757
120Resting tremor (HP:0002322)1.73636529
121Epistaxis (HP:0000421)1.71889774
122Bicuspid aortic valve (HP:0001647)1.71398478
123Nephritis (HP:0000123)1.71386517
124Biliary tract neoplasm (HP:0100574)1.71354869
125Abnormality of the peritoneum (HP:0002585)1.68837890
126Syringomyelia (HP:0003396)1.68786059
127Spinal cord lesions (HP:0100561)1.68786059
128Elfin facies (HP:0004428)1.68785861
129Increased connective tissue (HP:0009025)1.68598365
130Keratoconjunctivitis sicca (HP:0001097)1.68277525
131Bowed forearm bones (HP:0003956)1.68151488
132Bowing of the arm (HP:0006488)1.68151488
133Increased IgE level (HP:0003212)1.67178159
134Purpura (HP:0000979)1.66975494
135B lymphocytopenia (HP:0010976)1.66921498
136Abnormality of B cell number (HP:0010975)1.66921498
137Hypergammaglobulinemia (HP:0010702)1.66684202
138Narrow palate (HP:0000189)1.66255355
139Chest pain (HP:0100749)1.65980935
140Loss of speech (HP:0002371)1.65841110
141Recurrent otitis media (HP:0000403)1.65165413
142Hemoptysis (HP:0002105)1.65145776
143Disproportionate tall stature (HP:0001519)1.64811753
144Hypertriglyceridemia (HP:0002155)1.64688797
145Easy fatigability (HP:0003388)1.64044980
146Annular pancreas (HP:0001734)1.63249241
147Metaphyseal cupping (HP:0003021)1.62266406
148Cervical subluxation (HP:0003308)1.62122742
149Arterial thrombosis (HP:0004420)1.61428939
150Recurrent cutaneous fungal infections (HP:0011370)1.61069274
151Chronic mucocutaneous candidiasis (HP:0002728)1.61069274
152Spastic diplegia (HP:0001264)1.60999294
153Malignant gastrointestinal tract tumors (HP:0006749)1.60591850
154Gastrointestinal carcinoma (HP:0002672)1.60591850
155Bowel diverticulosis (HP:0005222)1.59858932
156Skin tags (HP:0010609)1.59855337
157Hypoproteinemia (HP:0003075)1.59570283
158Viral hepatitis (HP:0006562)1.59233091
159Abnormal platelet function (HP:0011869)1.59093096
160Impaired platelet aggregation (HP:0003540)1.59093096
161Lymphoma (HP:0002665)1.57854065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.59672134
2PRPF4B3.90883155
3MAP3K103.72825176
4EEF2K3.62493294
5GRK63.03141785
6CDK123.01038624
7PKN22.79048743
8TRIB32.77038135
9STK102.73082509
10SMG12.59489410
11ERN12.31355161
12FGFR42.16520349
13LRRK22.01670614
14BLK1.97870577
15JAK31.92731549
16IRAK41.88857731
17ITK1.76330965
18TTN1.69829123
19FLT31.67931266
20ZAP701.61007344
21FGFR31.55589016
22MAP3K31.50255850
23TGFBR21.49286304
24SIK31.48651779
25RIPK11.45257975
26MAP3K71.44232281
27BTK1.42731828
28PTK61.40471656
29MAP3K111.36677976
30TYK21.36491469
31MAP3K131.34685119
32JAK11.34259924
33TXK1.32190355
34CSF1R1.30036061
35RPS6KB21.28634274
36MAP3K11.27926379
37MAP3K141.27118043
38SIK11.26504279
39CSK1.22000193
40TYRO31.21916599
41SIK21.18118145
42KSR21.17868542
43BRD41.17706791
44PDGFRA1.14620999
45PAK41.14413943
46TESK21.12904313
47MAP2K31.11851525
48IRAK31.08687447
49CDK41.07241886
50HCK1.04327329
51ALK1.01476883
52PIM11.00529342
53LCK0.98966070
54TAOK20.94414807
55PRKD20.93744569
56PRKCH0.93314729
57KIT0.93160596
58CDC42BPA0.91443147
59PDPK10.90897983
60SYK0.90489240
61CDK60.88276582
62MTOR0.87570844
63FGR0.84796545
64IKBKE0.83965511
65PDGFRB0.82134621
66EPHA20.81882627
67MARK20.80342279
68TNK20.79622215
69MST1R0.79513358
70IRAK20.77885314
71JAK20.75860058
72CAMK1D0.75543848
73FGFR20.74886256
74TAOK10.73132586
75MAP3K60.72057096
76SGK30.71553840
77MAPK120.69640062
78MARK30.69107262
79CAMKK10.68635072
80HIPK20.68571670
81MAP3K80.68259465
82NEK20.65200361
83PASK0.63759144
84PDK10.62575154
85ARAF0.62317182
86RET0.60733218
87TRPM70.60513422
88MST40.59785441
89RPS6KA20.59775302
90TEC0.58942387
91CAMK1G0.56553553
92CLK10.55542435
93CDK90.54680744
94TGFBR10.54538483
95MAPKAPK30.52340708
96YES10.51105373
97PRKG20.51034821
98STK40.50667431
99MAP3K20.50082717
100MAPK110.49844302
101CDC70.49763670
102STK380.49568137
103FYN0.49523736
104MELK0.49432676
105PTK20.48842060
106ICK0.48817068
107NLK0.47270775
108MAPK70.47172810
109BMX0.45512399
110EPHB10.45414295
111PRKCQ0.44220947
112MAP2K20.43718666
113MAPK150.43704556
114CDK70.43469430
115DYRK1B0.43261695
116LMTK20.42975965
117RPS6KC10.42958205
118RPS6KL10.42958205
119RPS6KA60.42359282
120FGFR10.42321819
121IRAK10.41107734
122RIPK40.40797721
123IKBKB0.40193068
124ATR0.40108763
125TBK10.39156934
126CHUK0.38273159
127CAMK40.38179766
128STK110.37616449
129FES0.34546256
130CHEK10.34370527
131LYN0.33197202
132RPS6KA40.32889427

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.68902342
2B cell receptor signaling pathway_Homo sapiens_hsa046622.55581663
3T cell receptor signaling pathway_Homo sapiens_hsa046602.14513924
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.12508629
5Other glycan degradation_Homo sapiens_hsa005111.93879120
6Lysine degradation_Homo sapiens_hsa003101.85085148
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75204669
8Chronic myeloid leukemia_Homo sapiens_hsa052201.73176061
9Antigen processing and presentation_Homo sapiens_hsa046121.69691965
10Allograft rejection_Homo sapiens_hsa053301.66706002
11Acute myeloid leukemia_Homo sapiens_hsa052211.61224097
12Leukocyte transendothelial migration_Homo sapiens_hsa046701.60415011
13Autoimmune thyroid disease_Homo sapiens_hsa053201.59866960
14Small cell lung cancer_Homo sapiens_hsa052221.59731255
15Non-small cell lung cancer_Homo sapiens_hsa052231.59260226
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54810564
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54046806
18Staphylococcus aureus infection_Homo sapiens_hsa051501.53972631
19Graft-versus-host disease_Homo sapiens_hsa053321.53813267
20mTOR signaling pathway_Homo sapiens_hsa041501.51700160
21Platelet activation_Homo sapiens_hsa046111.48778482
22Pancreatic cancer_Homo sapiens_hsa052121.48005021
23Tuberculosis_Homo sapiens_hsa051521.45690193
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40766625
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34022525
26Osteoclast differentiation_Homo sapiens_hsa043801.30723316
27Hematopoietic cell lineage_Homo sapiens_hsa046401.30295068
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.24405156
29Measles_Homo sapiens_hsa051621.23935135
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19491572
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19082179
32Colorectal cancer_Homo sapiens_hsa052101.16260010
33VEGF signaling pathway_Homo sapiens_hsa043701.15009187
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.13255539
35Nitrogen metabolism_Homo sapiens_hsa009101.11127527
36Endometrial cancer_Homo sapiens_hsa052131.11036721
37Toxoplasmosis_Homo sapiens_hsa051451.10857627
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10854664
39Focal adhesion_Homo sapiens_hsa045101.09761886
40Leishmaniasis_Homo sapiens_hsa051401.08075728
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06892031
42Notch signaling pathway_Homo sapiens_hsa043301.06042803
43Adherens junction_Homo sapiens_hsa045201.05967295
44Insulin resistance_Homo sapiens_hsa049311.03993220
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01837934
46HTLV-I infection_Homo sapiens_hsa051661.00804212
47Hepatitis B_Homo sapiens_hsa051610.99063042
48Malaria_Homo sapiens_hsa051440.98152821
49Herpes simplex infection_Homo sapiens_hsa051680.97972233
50Proteoglycans in cancer_Homo sapiens_hsa052050.97484684
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95922264
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95766715
53Type I diabetes mellitus_Homo sapiens_hsa049400.95175157
54Viral myocarditis_Homo sapiens_hsa054160.93119183
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.92298414
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.90008766
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89563928
58GnRH signaling pathway_Homo sapiens_hsa049120.89357139
59Viral carcinogenesis_Homo sapiens_hsa052030.88931347
60Thyroid cancer_Homo sapiens_hsa052160.87936731
61ErbB signaling pathway_Homo sapiens_hsa040120.86286243
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86087632
63Salmonella infection_Homo sapiens_hsa051320.85264778
64MicroRNAs in cancer_Homo sapiens_hsa052060.85058868
65Inositol phosphate metabolism_Homo sapiens_hsa005620.84600815
66Chemokine signaling pathway_Homo sapiens_hsa040620.84022534
67Rap1 signaling pathway_Homo sapiens_hsa040150.82885836
68FoxO signaling pathway_Homo sapiens_hsa040680.81639406
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.80303077
70Glioma_Homo sapiens_hsa052140.79875669
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.79649730
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.79445454
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76732057
74Phagosome_Homo sapiens_hsa041450.76692534
75Asthma_Homo sapiens_hsa053100.75307462
76Fructose and mannose metabolism_Homo sapiens_hsa000510.75296470
77Non-homologous end-joining_Homo sapiens_hsa034500.75020788
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74971986
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73574402
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72141164
81Pertussis_Homo sapiens_hsa051330.71392908
82Apoptosis_Homo sapiens_hsa042100.71371380
83Shigellosis_Homo sapiens_hsa051310.71171737
84Pathways in cancer_Homo sapiens_hsa052000.69652823
85Amoebiasis_Homo sapiens_hsa051460.69479584
86Influenza A_Homo sapiens_hsa051640.68851043
87ECM-receptor interaction_Homo sapiens_hsa045120.68555097
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67863567
89Prolactin signaling pathway_Homo sapiens_hsa049170.67353048
90Lysosome_Homo sapiens_hsa041420.67336431
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66885421
92mRNA surveillance pathway_Homo sapiens_hsa030150.65663443
93Galactose metabolism_Homo sapiens_hsa000520.64919027
94Bladder cancer_Homo sapiens_hsa052190.63983847
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.63526670
96African trypanosomiasis_Homo sapiens_hsa051430.63028499
97Prostate cancer_Homo sapiens_hsa052150.62652812
98Hepatitis C_Homo sapiens_hsa051600.61665279
99Insulin signaling pathway_Homo sapiens_hsa049100.61146686
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60480994
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60274253
102Renal cell carcinoma_Homo sapiens_hsa052110.60144525
103Dorso-ventral axis formation_Homo sapiens_hsa043200.59721977
104Choline metabolism in cancer_Homo sapiens_hsa052310.58764984
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58401064
106Legionellosis_Homo sapiens_hsa051340.57710785
107ABC transporters_Homo sapiens_hsa020100.57657422
108Prion diseases_Homo sapiens_hsa050200.56763745
109Endocytosis_Homo sapiens_hsa041440.56544603
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.56435446
111N-Glycan biosynthesis_Homo sapiens_hsa005100.56038473
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54871106
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54313866
114Mismatch repair_Homo sapiens_hsa034300.54210403
115HIF-1 signaling pathway_Homo sapiens_hsa040660.54124093
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53837163
117p53 signaling pathway_Homo sapiens_hsa041150.52360652
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51362242
119Renin-angiotensin system_Homo sapiens_hsa046140.51214171
120Epstein-Barr virus infection_Homo sapiens_hsa051690.51206210
121AMPK signaling pathway_Homo sapiens_hsa041520.49998524
122Estrogen signaling pathway_Homo sapiens_hsa049150.48263183
123MAPK signaling pathway_Homo sapiens_hsa040100.47356853
124Base excision repair_Homo sapiens_hsa034100.47104906
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46400553
126TNF signaling pathway_Homo sapiens_hsa046680.46014754
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45665170

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