ARHGEF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)6.11191877
2daunorubicin metabolic process (GO:0044597)6.11191877
3polyketide metabolic process (GO:0030638)6.11191877
4proline transport (GO:0015824)4.50419677
5maintenance of protein location in nucleus (GO:0051457)4.34852101
6synaptic vesicle maturation (GO:0016188)4.25854782
7hormone catabolic process (GO:0042447)4.13980459
8aminoglycoside antibiotic metabolic process (GO:0030647)4.09569160
9negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.02106782
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.99260903
11somite rostral/caudal axis specification (GO:0032525)3.98082747
12positive regulation of histone deacetylation (GO:0031065)3.90473628
13cellular modified amino acid catabolic process (GO:0042219)3.75487236
14negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.72670751
15histone H4-K8 acetylation (GO:0043982)3.67483202
16histone H4-K5 acetylation (GO:0043981)3.67483202
17coenzyme catabolic process (GO:0009109)3.54849881
18macrophage activation involved in immune response (GO:0002281)3.52977957
19response to dietary excess (GO:0002021)3.52020567
20negative regulation of potassium ion transmembrane transport (GO:1901380)3.50686457
21response to peptidoglycan (GO:0032494)3.49686801
22protein localization to endosome (GO:0036010)3.44186917
23negative regulation of cell cycle G2/M phase transition (GO:1902750)3.39416293
24detection of molecule of bacterial origin (GO:0032490)3.36469171
25negative regulation of epidermis development (GO:0045683)3.34020515
26regulation of response to osmotic stress (GO:0047484)3.32523307
27histone H4-K12 acetylation (GO:0043983)3.31694442
28negative regulation of erythrocyte differentiation (GO:0045647)3.30547500
29regulation of mammary gland epithelial cell proliferation (GO:0033599)3.27640873
30positive regulation by symbiont of host defense response (GO:0052509)3.22315298
31modulation by symbiont of host defense response (GO:0052031)3.22315298
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.22315298
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.22315298
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.22315298
35modulation by symbiont of host immune response (GO:0052553)3.22315298
36mitochondrion distribution (GO:0048311)3.21418471
37phenol-containing compound catabolic process (GO:0019336)3.19961713
38negative regulation of cell size (GO:0045792)3.19577845
39muscle organ morphogenesis (GO:0048644)3.19046685
40pre-miRNA processing (GO:0031054)3.18924849
41epoxygenase P450 pathway (GO:0019373)3.17174222
42regulation of glucose import in response to insulin stimulus (GO:2001273)3.17086740
43NLS-bearing protein import into nucleus (GO:0006607)3.15959388
44negative regulation of interleukin-12 production (GO:0032695)3.13260736
45positive regulation of protein deacetylation (GO:0090312)3.12755947
46negative regulation of telomerase activity (GO:0051974)3.12157004
47negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.05012566
48positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.02740822
49notochord development (GO:0030903)3.01623032
50histone H4-K16 acetylation (GO:0043984)3.00257517
51branching involved in mammary gland duct morphogenesis (GO:0060444)2.99429820
52positive regulation of cellular amide metabolic process (GO:0034250)2.98562224
53regulation of T-helper 2 cell differentiation (GO:0045628)2.97829197
54primitive streak formation (GO:0090009)2.96669566
55protein targeting to Golgi (GO:0000042)2.95804204
56heterochromatin organization (GO:0070828)2.89754313
57hypotonic response (GO:0006971)2.88478963
58lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88137197
59detection of temperature stimulus (GO:0016048)2.86890210
60positive regulation of macrophage cytokine production (GO:0060907)2.86710958
61regulation of telomere maintenance via telomerase (GO:0032210)2.86213917
62detection of other organism (GO:0098543)2.86133343
63regulation of MHC class I biosynthetic process (GO:0045343)2.85902634
64regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.85879450
65regulation of ARF protein signal transduction (GO:0032012)2.84521265
66cytidine deamination (GO:0009972)2.83811227
67cytidine metabolic process (GO:0046087)2.83811227
68cytidine catabolic process (GO:0006216)2.83811227
69sulfur amino acid catabolic process (GO:0000098)2.81074266
70barbed-end actin filament capping (GO:0051016)2.78407079
71vitamin A metabolic process (GO:0006776)2.78269332
72mannose metabolic process (GO:0006013)2.77361866
73intestinal epithelial cell development (GO:0060576)2.76660007
74stress granule assembly (GO:0034063)2.76342804
75establishment of protein localization to Golgi (GO:0072600)2.75636972
76detection of external biotic stimulus (GO:0098581)2.75404102
77maintenance of protein localization in organelle (GO:0072595)2.74878129
78negative regulation of cell killing (GO:0031342)2.73799250
79negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.73799250
80glycosphingolipid catabolic process (GO:0046479)2.72801801
81regulation of early endosome to late endosome transport (GO:2000641)2.72141006
82response to laminar fluid shear stress (GO:0034616)2.69981651
83positive regulation of Cdc42 GTPase activity (GO:0043089)2.69216026
84epithelial cell differentiation involved in prostate gland development (GO:0060742)2.68314460
85retrograde transport, vesicle recycling within Golgi (GO:0000301)2.64659364
86intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.63625688
87pyrimidine ribonucleoside catabolic process (GO:0046133)2.63052855
88response to muramyl dipeptide (GO:0032495)2.62387243
89cellular response to thyroid hormone stimulus (GO:0097067)2.59094660
90regulation of membrane protein ectodomain proteolysis (GO:0051043)2.57567854
91stress fiber assembly (GO:0043149)2.57089293
92ovulation cycle (GO:0042698)2.55614444
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52563040
94maternal placenta development (GO:0001893)2.52509672
95positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.52298970
96germinal center formation (GO:0002467)2.52202064
97detection of bacterium (GO:0016045)2.51733521
98regulation of hippo signaling (GO:0035330)2.51629171
99cytoskeletal anchoring at plasma membrane (GO:0007016)2.51618253
100macroautophagy (GO:0016236)2.50178641
101apoptotic cell clearance (GO:0043277)2.49556041
102positive regulation of type 2 immune response (GO:0002830)2.49453533
103sodium ion export (GO:0071436)2.49403322
104protein localization to kinetochore (GO:0034501)2.49114850
105positive regulation of gamma-delta T cell activation (GO:0046645)2.46963795
106bone trabecula formation (GO:0060346)2.46611152
107detection of biotic stimulus (GO:0009595)2.46252040
108positive regulation of receptor recycling (GO:0001921)2.45410368
109cell migration involved in gastrulation (GO:0042074)2.44927656
110regulation of NFAT protein import into nucleus (GO:0051532)2.44501375
111semaphorin-plexin signaling pathway (GO:0071526)2.43928949
112glycolipid catabolic process (GO:0019377)2.42914118
113regulation of leukocyte degranulation (GO:0043300)2.42128974
114mitochondrion localization (GO:0051646)2.42025960
115regulation of interferon-beta biosynthetic process (GO:0045357)2.41338880
116locomotory exploration behavior (GO:0035641)2.41201477
117glutamate secretion (GO:0014047)2.40371159
118establishment of nucleus localization (GO:0040023)2.40351355
119biotin metabolic process (GO:0006768)2.40251597
120retinoic acid receptor signaling pathway (GO:0048384)2.38998957
121nuclear pore complex assembly (GO:0051292)2.37828541
122negative regulation of toll-like receptor signaling pathway (GO:0034122)2.37525393
123cortical actin cytoskeleton organization (GO:0030866)2.36615465
124cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36435313
125regulation of type 2 immune response (GO:0002828)2.35926481
126neutrophil activation involved in immune response (GO:0002283)2.34732259
127macrophage activation (GO:0042116)2.34483469
128nerve growth factor signaling pathway (GO:0038180)2.32936607
129type I interferon signaling pathway (GO:0060337)2.31510668
130cellular response to type I interferon (GO:0071357)2.31510668
131response to type I interferon (GO:0034340)2.30329602
132cell-cell junction maintenance (GO:0045217)2.30252010
133cardiovascular system development (GO:0072358)2.29710350
134synaptic vesicle docking involved in exocytosis (GO:0016081)2.29555705
135regulation of dendritic cell antigen processing and presentation (GO:0002604)2.28466311
136layer formation in cerebral cortex (GO:0021819)2.28386700
137receptor recycling (GO:0001881)2.28105598
138calcium-mediated signaling using intracellular calcium source (GO:0035584)2.27600258
139adherens junction assembly (GO:0034333)2.27286959
140nucleoside transmembrane transport (GO:1901642)2.26354349
141mRNA stabilization (GO:0048255)2.24506804
142RNA stabilization (GO:0043489)2.24506804
143regulation of ARF GTPase activity (GO:0032312)2.23732709
144transepithelial transport (GO:0070633)2.23087391
145regulation of myeloid leukocyte mediated immunity (GO:0002886)2.23047868
146phosphatidylinositol 3-kinase signaling (GO:0014065)2.22274447
147embryonic process involved in female pregnancy (GO:0060136)2.20367611
148regulation of short-term neuronal synaptic plasticity (GO:0048172)2.20062716
149positive regulation of axon extension (GO:0045773)2.19638357
150negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.18308837
151plasma membrane repair (GO:0001778)2.18046788
152regulation of apoptotic cell clearance (GO:2000425)2.17600139
153regulation of cilium movement (GO:0003352)2.17548752
154cardiac muscle cell proliferation (GO:0060038)2.16181241
155regulation of podosome assembly (GO:0071801)2.15675783
156antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.15662831
157negative regulation of fatty acid transport (GO:2000192)2.15622573
158cortical cytoskeleton organization (GO:0030865)2.14949296
159regulation of cholesterol homeostasis (GO:2000188)2.14380850
160antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.13875250
161tachykinin receptor signaling pathway (GO:0007217)2.13792883
162basement membrane organization (GO:0071711)2.13691549
163response to manganese ion (GO:0010042)2.13681529
164rRNA transcription (GO:0009303)2.13469327
165regulation of vitamin D biosynthetic process (GO:0060556)2.13306994
166microtubule severing (GO:0051013)2.13099921
167positive regulation of leukocyte degranulation (GO:0043302)2.11855493
168regulation of regulated secretory pathway (GO:1903305)2.11781537
169signal complex assembly (GO:0007172)2.11376999
170T-helper 1 type immune response (GO:0042088)2.10831928
171negative regulation of cytokine production involved in immune response (GO:0002719)2.10717731
172modulation by symbiont of host cellular process (GO:0044068)2.09178435
173regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.08554133
174production of molecular mediator involved in inflammatory response (GO:0002532)2.07815753
175negative regulation of type 2 immune response (GO:0002829)2.06271160
176response to thyroid hormone (GO:0097066)2.05666689
177focal adhesion assembly (GO:0048041)2.05556493
178cell-substrate adherens junction assembly (GO:0007045)2.05556493
179regulation of type I interferon-mediated signaling pathway (GO:0060338)2.05183441
180regulation of macrophage cytokine production (GO:0010935)2.04275678
181regulation of mast cell degranulation (GO:0043304)2.04258584
182L-amino acid import (GO:0043092)2.03440386
183antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.02948030
184pinocytosis (GO:0006907)2.01533459
185regulation of interferon-alpha production (GO:0032647)2.00958230
186regulation of gamma-delta T cell activation (GO:0046643)2.00950694
187response to host (GO:0075136)2.00844016
188response to host defenses (GO:0052200)2.00844016
189response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.00844016
190positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.00779177
191response to host immune response (GO:0052572)1.99912356
192response to immune response of other organism involved in symbiotic interaction (GO:0052564)1.99912356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.28472152
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.28472152
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.28472152
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.82120935
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.09719376
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.48556697
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37929448
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19746088
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.17565113
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.13247369
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.12938930
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.12203676
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.09691406
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00752752
15ZFP281_27345836_Chip-Seq_ESCs_Mouse1.98612937
16* KDM2B_26808549_Chip-Seq_K562_Human1.95328295
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.94811223
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92847149
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.89541368
20VDR_21846776_ChIP-Seq_THP-1_Human1.87603270
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85812924
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85369578
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.85230191
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.84898190
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84665054
26* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82097535
27IRF8_27001747_Chip-Seq_BMDM_Mouse1.81386969
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.80685576
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78307130
30NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.76539116
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73026232
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.72992609
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.72061420
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70372049
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68369545
36TCF3_18692474_ChIP-Seq_MESCs_Mouse1.66674820
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63882839
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.62045304
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.58035498
40* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57081398
41CLOCK_20551151_ChIP-Seq_293T_Human1.56051237
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55565935
43VDR_24763502_ChIP-Seq_THP-1_Human1.54100699
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53316948
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51073488
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.50545303
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49449660
48SPI1_23127762_ChIP-Seq_K562_Human1.47460298
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.46372725
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45385752
51* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44252371
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41929507
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.40098146
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.39599098
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.38771040
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37933756
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37510370
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.37504731
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37277771
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.35728262
61EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35633344
62TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.33783905
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.32663463
64LXR_22292898_ChIP-Seq_THP-1_Human1.30604965
65* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.29167148
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28978989
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.28953167
68* TCF7_22412390_ChIP-Seq_EML_Mouse1.28216002
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.28121890
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26142250
71KDM2B_26808549_Chip-Seq_DND41_Human1.25226850
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24495889
73MYC_22102868_ChIP-Seq_BL_Human1.22832333
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22517606
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22517606
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22500760
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22109180
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21994394
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21872866
80TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.21444931
81TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21085144
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20985109
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20938846
84TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20883468
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20845026
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19672992
87SMC4_20622854_ChIP-Seq_HELA_Human1.19671227
88* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18579144
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18106365
90LXR_22158963_ChIP-Seq_LIVER_Mouse1.16096054
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.15867992
92TBX20_22328084_ChIP-Seq_HEART_Mouse1.15867992
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15806294
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15262273
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15117718
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.14234347
97* RACK7_27058665_Chip-Seq_MCF-7_Human1.13753230
98* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13602183
99VDR_24787735_ChIP-Seq_THP-1_Human1.13061516
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13017546
101AHR_22903824_ChIP-Seq_MCF-7_Human1.12784554
102SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12522434
103RUNX1_22412390_ChIP-Seq_EML_Mouse1.11409636
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10808142
105NANOG_16518401_ChIP-PET_MESCs_Mouse1.10052541
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09267096
107* GATA2_21666600_ChIP-Seq_HMVEC_Human1.08090412
108CREB1_26743006_Chip-Seq_LNCaP_Human1.07386598
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07009366
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06254619
111CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06142889
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06101476
113GATA1_19941826_ChIP-Seq_K562_Human1.04750383
114RXR_22158963_ChIP-Seq_LIVER_Mouse1.04724702
115TP53_22127205_ChIP-Seq_IMR90_Human1.03835838
116ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03818237
117GATA1_22025678_ChIP-Seq_K562_Human1.03668303
118* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02217641
119* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01860033
120NANOG_18692474_ChIP-Seq_MESCs_Mouse1.01719111
121MAF_26560356_Chip-Seq_TH1_Human1.01566645
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01265138
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00167902
124FOXA2_19822575_ChIP-Seq_HepG2_Human0.99156791
125DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98990515
126ELK3_25401928_ChIP-Seq_HUVEC_Human0.98831240
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98079928
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97768316
129ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97714477
130RUNX1_27514584_Chip-Seq_MCF-7_Human0.97578985
131E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97443390
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.96697639
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95800110
134TRIM28_21343339_ChIP-Seq_HEK293_Human0.95451478
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95254008
136* SMAD3_21741376_ChIP-Seq_HESCs_Human0.94792362
137* KDM2B_26808549_Chip-Seq_JURKAT_Human0.94454071
138SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94433096
139PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94339548
140RNF2_27304074_Chip-Seq_ESCs_Mouse0.92712087
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92435170
142UBF1/2_26484160_Chip-Seq_HMECs_Human0.92004541
143* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91754954
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91254663
145GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90664002
146ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90658698
147RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90599156
148ARNT_22903824_ChIP-Seq_MCF-7_Human0.90463584
149FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90218778
150NCOR1_26117541_ChIP-Seq_K562_Human0.89058533
151PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88319788
152* AR_19668381_ChIP-Seq_PC3_Human0.88300934
153KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88010268
154ISL1_27105846_Chip-Seq_CPCs_Mouse0.87675682
155DROSHA_22980978_ChIP-Seq_HELA_Human0.86940377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.48970379
2MP0004858_abnormal_nervous_system4.45872300
3MP0003303_peritoneal_inflammation4.30361121
4MP0003705_abnormal_hypodermis_morpholog4.28751145
5MP0004264_abnormal_extraembryonic_tissu4.00628626
6MP0005058_abnormal_lysosome_morphology3.56869725
7MP0003011_delayed_dark_adaptation3.46049844
8MP0008961_abnormal_basal_metabolism2.94240726
9MP0003122_maternal_imprinting2.88072870
10MP0005451_abnormal_body_composition2.79655595
11MP0003724_increased_susceptibility_to2.72880256
12MP0005257_abnormal_intraocular_pressure2.71467121
13MP0003436_decreased_susceptibility_to2.67608107
14MP0004510_myositis2.66200177
15MP0003890_abnormal_embryonic-extraembry2.65114104
16MP0003191_abnormal_cellular_cholesterol2.43990844
17MP0005394_taste/olfaction_phenotype2.41831744
18MP0005499_abnormal_olfactory_system2.41831744
19MP0003690_abnormal_glial_cell2.37316498
20MP0003283_abnormal_digestive_organ2.36736474
21MP0006082_CNS_inflammation2.33073734
22MP0009840_abnormal_foam_cell2.28318344
23MP0002909_abnormal_adrenal_gland2.11079141
24MP0003183_abnormal_peptide_metabolism2.10458938
25MP0010352_gastrointestinal_tract_polyps2.08380506
26MP0002332_abnormal_exercise_endurance2.05727492
27MP0003329_amyloid_beta_deposits2.01828264
28MP0004859_abnormal_synaptic_plasticity1.99857057
29MP0003075_altered_response_to1.97763190
30MP0002653_abnormal_ependyma_morphology1.95990410
31MP0008260_abnormal_autophagy1.95208959
32MP0009278_abnormal_bone_marrow1.91654918
33MP0000604_amyloidosis1.89563728
34MP0005409_darkened_coat_color1.89309854
35MP0008438_abnormal_cutaneous_collagen1.89175743
36MP0003453_abnormal_keratinocyte_physiol1.88176449
37MP0002419_abnormal_innate_immunity1.87226524
38MP0001533_abnormal_skeleton_physiology1.80407111
39MP0001849_ear_inflammation1.77831477
40MP0004947_skin_inflammation1.74808499
41MP0002998_abnormal_bone_remodeling1.74129819
42MP0003121_genomic_imprinting1.71176249
43MP0003045_fibrosis1.65837682
44MP0003828_pulmonary_edema1.60376341
45MP0006292_abnormal_olfactory_placode1.59820368
46MP0005248_abnormal_Harderian_gland1.58339255
47MP0004270_analgesia1.57503585
48MP0008004_abnormal_stomach_pH1.53610206
49MP0005025_abnormal_response_to1.51789663
50MP0000920_abnormal_myelination1.51396641
51MP0009785_altered_susceptibility_to1.50384662
52MP0000678_abnormal_parathyroid_gland1.47578179
53MP0001835_abnormal_antigen_presentation1.44636487
54MP0004043_abnormal_pH_regulation1.43464199
55MP0002148_abnormal_hypersensitivity_rea1.40684229
56MP0001958_emphysema1.36047611
57MP0000569_abnormal_digit_pigmentation1.35424040
58MP0003879_abnormal_hair_cell1.34097120
59MP0003787_abnormal_imprinting1.30650485
60MP0005623_abnormal_meninges_morphology1.29541986
61MP0000858_altered_metastatic_potential1.28067237
62MP0002269_muscular_atrophy1.27360926
63MP0002877_abnormal_melanocyte_morpholog1.26466533
64MP0009780_abnormal_chondrocyte_physiolo1.26106562
65MP0003252_abnormal_bile_duct1.26041690
66MP0005000_abnormal_immune_tolerance1.26016434
67MP0003448_altered_tumor_morphology1.24007358
68MP0003279_aneurysm1.23883722
69MP0001790_abnormal_immune_system1.22684452
70MP0005387_immune_system_phenotype1.22684452
71MP0002127_abnormal_cardiovascular_syste1.21064848
72MP0005075_abnormal_melanosome_morpholog1.21003691
73MP0003634_abnormal_glial_cell1.20820498
74MP0010234_abnormal_vibrissa_follicle1.19163628
75MP0006035_abnormal_mitochondrial_morpho1.18585164
76MP0002088_abnormal_embryonic_growth/wei1.15640546
77MP0000343_altered_response_to1.15389410
78MP0005360_urolithiasis1.15236584
79MP0005166_decreased_susceptibility_to1.14844489
80MP0003984_embryonic_growth_retardation1.11909723
81MP0005380_embryogenesis_phenotype1.10458013
82MP0001672_abnormal_embryogenesis/_devel1.10458013
83MP0001348_abnormal_lacrimal_gland1.10306356
84MP0000428_abnormal_craniofacial_morphol1.09651487
85MP0010155_abnormal_intestine_physiology1.06027378
86MP0003137_abnormal_impulse_conducting1.03922243
87MP0004272_abnormal_basement_membrane1.03216229
88MP0003123_paternal_imprinting1.01980149
89MP0005365_abnormal_bile_salt1.00380371
90MP0003119_abnormal_digestive_system0.99820089
91MP0002896_abnormal_bone_mineralization0.99658484
92MP0003935_abnormal_craniofacial_develop0.99573447
93MP0005167_abnormal_blood-brain_barrier0.99528601
94MP0005397_hematopoietic_system_phenotyp0.99183620
95MP0001545_abnormal_hematopoietic_system0.99183620
96MP0003172_abnormal_lysosome_physiology0.97235766
97MP0001270_distended_abdomen0.97123215
98MP0002452_abnormal_antigen_presenting0.95907846
99MP0010368_abnormal_lymphatic_system0.94937070
100MP0002932_abnormal_joint_morphology0.94719164
101MP0005164_abnormal_response_to0.94501992
102MP0002092_abnormal_eye_morphology0.94468253
103MP0000767_abnormal_smooth_muscle0.93261079
104MP0009046_muscle_twitch0.91893085
105MP0010030_abnormal_orbit_morphology0.91676592
106MP0001851_eye_inflammation0.91333640
107MP0005390_skeleton_phenotype0.91188502
108MP0002723_abnormal_immune_serum0.91032837
109MP0004233_abnormal_muscle_weight0.90788235
110MP0008874_decreased_physiological_sensi0.90343660
111MP0002970_abnormal_white_adipose0.90160026
112MP0002925_abnormal_cardiovascular_devel0.88677192
113MP0005375_adipose_tissue_phenotype0.88305579
114MP0000733_abnormal_muscle_development0.88286847
115MP0000955_abnormal_spinal_cord0.87771385
116MP0004087_abnormal_muscle_fiber0.87641226
117MP0002086_abnormal_extraembryonic_tissu0.86987864
118MP0003566_abnormal_cell_adhesion0.86749181
119MP0008770_decreased_survivor_rate0.86185927
120MP0009703_decreased_birth_body0.85671806
121MP0004130_abnormal_muscle_cell0.85421754
122MP0003938_abnormal_ear_development0.84826812
123MP0002233_abnormal_nose_morphology0.84409263
124MP0000747_muscle_weakness0.83927231
125MP0005076_abnormal_cell_differentiation0.83910661
126MP0004185_abnormal_adipocyte_glucose0.83723580
127MP0004883_abnormal_blood_vessel0.83669773
128MP0004084_abnormal_cardiac_muscle0.82878614
129MP0000749_muscle_degeneration0.82836957
130MP0003635_abnormal_synaptic_transmissio0.82138548
131MP0010329_abnormal_lipoprotein_level0.81668882
132MP0001845_abnormal_inflammatory_respons0.81470428
133MP0002139_abnormal_hepatobiliary_system0.78916354
134MP0000685_abnormal_immune_system0.78365705
135MP0001915_intracranial_hemorrhage0.77995855
136MP0004085_abnormal_heartbeat0.77856159
137MP0003091_abnormal_cell_migration0.77802783
138MP0008469_abnormal_protein_level0.77747490
139MP0009764_decreased_sensitivity_to0.77381322
140MP0000762_abnormal_tongue_morphology0.77119333
141MP0002733_abnormal_thermal_nociception0.76434265
142MP0001819_abnormal_immune_cell0.75480531
143MP0002108_abnormal_muscle_morphology0.75299863
144MP0005670_abnormal_white_adipose0.75249659
145MP0005266_abnormal_metabolism0.75208531
146MP0005310_abnormal_salivary_gland0.74619610
147MP0010630_abnormal_cardiac_muscle0.73724143
148MP0002420_abnormal_adaptive_immunity0.73337177
149MP0000534_abnormal_ureter_morphology0.73196328
150MP0003300_gastrointestinal_ulcer0.72886835
151MP0000759_abnormal_skeletal_muscle0.72611482
152MP0002084_abnormal_developmental_patter0.72539067
153MP0002089_abnormal_postnatal_growth/wei0.72252987
154MP0001800_abnormal_humoral_immune0.71950493
155MP0000432_abnormal_head_morphology0.71331358
156MP0000750_abnormal_muscle_regeneration0.70123637
157MP0005165_increased_susceptibility_to0.69724864
158MP0002405_respiratory_system_inflammati0.69651845
159MP0005023_abnormal_wound_healing0.69517665
160MP0005464_abnormal_platelet_physiology0.68822990
161MP0001293_anophthalmia0.68021034
162MP0003632_abnormal_nervous_system0.67555619
163MP0002734_abnormal_mechanical_nocicepti0.67268372
164MP0001853_heart_inflammation0.66833230
165MP0005666_abnormal_adipose_tissue0.66821257
166MP0005197_abnormal_uvea_morphology0.65949304
167MP0004197_abnormal_fetal_growth/weight/0.65896298
168MP0003755_abnormal_palate_morphology0.65842877
169MP0005508_abnormal_skeleton_morphology0.65659024
170MP0002063_abnormal_learning/memory/cond0.65546964
171MP0002114_abnormal_axial_skeleton0.65194383
172MP0002085_abnormal_embryonic_tissue0.64542515
173MP0000371_diluted_coat_color0.64288775
174MP0005621_abnormal_cell_physiology0.64235657
175MP0009115_abnormal_fat_cell0.64152224
176MP0003795_abnormal_bone_structure0.62918633
177MP0000751_myopathy0.62266400

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)5.44306601
2Bilateral microphthalmos (HP:0007633)5.34184453
3Hepatoblastoma (HP:0002884)5.14840289
4Hypochromic microcytic anemia (HP:0004840)4.97555712
5Abnormality of glycolipid metabolism (HP:0010969)3.62306974
6Abnormality of liposaccharide metabolism (HP:0010968)3.62306974
7Abnormality of glycosphingolipid metabolism (HP:0004343)3.62306974
8Eczematoid dermatitis (HP:0000976)3.48661357
9Ependymoma (HP:0002888)3.42831058
10Neurofibrillary tangles (HP:0002185)3.34269274
11Hyperinsulinemic hypoglycemia (HP:0000825)3.26605165
12Difficulty running (HP:0009046)3.22067948
13Abnormality of the astrocytes (HP:0100707)3.19586560
14Astrocytoma (HP:0009592)3.19586560
15Multiple enchondromatosis (HP:0005701)3.14249524
16Hand muscle atrophy (HP:0009130)3.11648363
17Neoplasm of the heart (HP:0100544)3.01103284
18Increased cerebral lipofuscin (HP:0011813)2.97689449
19Abnormality of macrophages (HP:0004311)2.90903999
20Neoplasm of striated muscle (HP:0009728)2.87458367
21Systemic lupus erythematosus (HP:0002725)2.87079486
22Cerebral inclusion bodies (HP:0100314)2.87046766
23Increased connective tissue (HP:0009025)2.87010145
24Dysostosis multiplex (HP:0000943)2.84178510
25Orchitis (HP:0100796)2.81955455
26Loss of speech (HP:0002371)2.80152289
27Rib fusion (HP:0000902)2.79933115
28Distal upper limb amyotrophy (HP:0007149)2.79574317
29Upper limb amyotrophy (HP:0009129)2.79574317
30Macroorchidism (HP:0000053)2.79316993
31Obstructive sleep apnea (HP:0002870)2.77060065
32Renal duplication (HP:0000075)2.73146431
33Skin nodule (HP:0200036)2.59526136
34Amyotrophic lateral sclerosis (HP:0007354)2.57574305
35Resting tremor (HP:0002322)2.54735798
36Lymphangioma (HP:0100764)2.54405940
37Tetraplegia (HP:0002445)2.54299117
38Recurrent bacterial skin infections (HP:0005406)2.51206954
39Recurrent gram-negative bacterial infections (HP:0005420)2.50921752
40Recurrent abscess formation (HP:0002722)2.48746134
41Retrobulbar optic neuritis (HP:0100654)2.48472600
42Optic neuritis (HP:0100653)2.48472600
43Amyloidosis (HP:0011034)2.45568054
44Myositis (HP:0100614)2.44408706
45Supranuclear gaze palsy (HP:0000605)2.42618056
46Interstitial pulmonary disease (HP:0006530)2.41335090
47Hypopigmentation of the fundus (HP:0007894)2.39105731
48Horizontal nystagmus (HP:0000666)2.36015425
49Gingivitis (HP:0000230)2.35652076
50Urinary glycosaminoglycan excretion (HP:0003541)2.34881593
51Mucopolysacchariduria (HP:0008155)2.34881593
52Pseudobulbar signs (HP:0002200)2.33837546
53Neuronal loss in central nervous system (HP:0002529)2.32127076
54Abnormality of polysaccharide metabolism (HP:0011012)2.32071489
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.32071489
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.32071489
57Thin bony cortex (HP:0002753)2.32013116
58Testicular atrophy (HP:0000029)2.31722805
59Protrusio acetabuli (HP:0003179)2.29466001
60Achilles tendon contracture (HP:0001771)2.28734334
61Nuclear cataract (HP:0100018)2.28357147
62Abnormal cartilage morphology (HP:0002763)2.28062085
63Rhabdomyosarcoma (HP:0002859)2.27437812
64Mildly elevated creatine phosphokinase (HP:0008180)2.25878306
65Abnormality of the salivary glands (HP:0010286)2.25616203
66Glioma (HP:0009733)2.24642658
67Hyperventilation (HP:0002883)2.24222043
68Broad face (HP:0000283)2.24139248
69Vertebral compression fractures (HP:0002953)2.23011552
70Abnormality of the Achilles tendon (HP:0005109)2.22961304
71Abnormality of the musculature of the hand (HP:0001421)2.22412156
72Cerebral aneurysm (HP:0004944)2.21216486
73Generalized hypotonia (HP:0001290)2.20711417
74Upper motor neuron abnormality (HP:0002127)2.19876727
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.19533100
76Hypoplasia of the fovea (HP:0007750)2.18653633
77Aplasia/Hypoplasia of the fovea (HP:0008060)2.18653633
78Shawl scrotum (HP:0000049)2.16489123
79Apathy (HP:0000741)2.11833720
80EMG: neuropathic changes (HP:0003445)2.11588269
81Hyperacusis (HP:0010780)2.10984446
82Glomerulonephritis (HP:0000099)2.09337278
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06687739
84Myocardial infarction (HP:0001658)2.05921507
85Segmental peripheral demyelination/remyelination (HP:0003481)2.04817295
86Asymmetric septal hypertrophy (HP:0001670)2.04077244
87Disinhibition (HP:0000734)2.03118715
88Flat acetabular roof (HP:0003180)2.02411872
89Amblyopia (HP:0000646)2.01469198
90Ragged-red muscle fibers (HP:0003200)2.01167694
91Distal lower limb amyotrophy (HP:0008944)2.00514461
92Large earlobe (HP:0009748)1.99610037
93Axonal loss (HP:0003447)1.99596111
94Aplasia/Hypoplasia of the macula (HP:0008059)1.98898427
95Premature rupture of membranes (HP:0001788)1.96968335
96Spastic tetraparesis (HP:0001285)1.95518593
97Cervical subluxation (HP:0003308)1.95328737
98Diminished motivation (HP:0000745)1.95144636
99Abnormality of the intrinsic pathway (HP:0010989)1.94819130
100Abnormality of complement system (HP:0005339)1.93676558
101Fused cervical vertebrae (HP:0002949)1.93555027
102Short humerus (HP:0005792)1.92747853
103Mitral valve prolapse (HP:0001634)1.91966955
104Shallow orbits (HP:0000586)1.91715605
105Malignant neoplasm of the central nervous system (HP:0100836)1.91379309
106Supernumerary nipples (HP:0002558)1.90413691
107Hamartoma of the eye (HP:0010568)1.90122756
108Abnormality of chromosome segregation (HP:0002916)1.90049045
109Aplasia/Hypoplasia affecting the retina (HP:0008061)1.89898016
110Bifid tongue (HP:0010297)1.87346819
111Gout (HP:0001997)1.87301671
112Onion bulb formation (HP:0003383)1.86543791
113Mutism (HP:0002300)1.85343201
114Aneurysm (HP:0002617)1.85015697
115Distal lower limb muscle weakness (HP:0009053)1.83357477
116Complement deficiency (HP:0004431)1.82846454
117Open mouth (HP:0000194)1.80957096
118Abnormality of the corticospinal tract (HP:0002492)1.79485493
119Intestinal fistula (HP:0100819)1.78768516
120Increased variability in muscle fiber diameter (HP:0003557)1.78732803
121Osteolytic defects of the hand bones (HP:0009699)1.78588598
122Osteolytic defects of the phalanges of the hand (HP:0009771)1.78588598
123Lower limb amyotrophy (HP:0007210)1.77187924
124Status epilepticus (HP:0002133)1.76659217
125Abnormality of the pubic bones (HP:0003172)1.76526347
126Abnormality of the distal phalanx of the thumb (HP:0009617)1.76067416
127Pathologic fracture (HP:0002756)1.75663084
128Preauricular pit (HP:0004467)1.74981875
129Periauricular skin pits (HP:0100277)1.74981875
130Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73894504
131Skin tags (HP:0010609)1.73692823
132Spontaneous hematomas (HP:0007420)1.73540802
133Bone pain (HP:0002653)1.73207639
134Neuroectodermal neoplasm (HP:0030061)1.72984335
135Neuroepithelial neoplasm (HP:0030063)1.72984335
136Nervous tissue neoplasm (HP:0030060)1.72984335
137Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71873767
138Preauricular skin tag (HP:0000384)1.71510564
139Abnormality of the fovea (HP:0000493)1.70961785
140Febrile seizures (HP:0002373)1.70570766
141Nephroblastoma (Wilms tumor) (HP:0002667)1.70243219
142Ankyloglossia (HP:0010296)1.68759253
143Dilatation of the ascending aorta (HP:0005111)1.68156120
144Keratoconjunctivitis sicca (HP:0001097)1.68151013
145Focal seizures (HP:0007359)1.67774123
146Disproportionate tall stature (HP:0001519)1.67165167
147Mediastinal lymphadenopathy (HP:0100721)1.67041610
148Embryonal renal neoplasm (HP:0011794)1.66931059
149Decreased motor nerve conduction velocity (HP:0003431)1.66244973
150Cellulitis (HP:0100658)1.66093898
151Hyperparathyroidism (HP:0000843)1.65974769
152Heterotopia (HP:0002282)1.65382919
153Increased CSF protein (HP:0002922)1.65084947
154Centrally nucleated skeletal muscle fibers (HP:0003687)1.64900671
155Peritonitis (HP:0002586)1.64849295
156Visceral angiomatosis (HP:0100761)1.64601547
157Arterial tortuosity (HP:0005116)1.62584900
158Aplasia/hypoplasia of the humerus (HP:0006507)1.62074301
159Hemorrhage of the eye (HP:0011885)1.61380362
160Action tremor (HP:0002345)1.61364179
161Hemiparesis (HP:0001269)1.61353959
162Short 5th finger (HP:0009237)1.61116453
163Vacuolated lymphocytes (HP:0001922)1.60746034
164Fibroma (HP:0010614)1.60556346
165Skin pits (HP:0100276)1.60390682
166Uterine leiomyosarcoma (HP:0002891)1.60231608
167Leiomyosarcoma (HP:0100243)1.60231608
168Excessive salivation (HP:0003781)1.59956115
169Drooling (HP:0002307)1.59956115
170Subacute progressive viral hepatitis (HP:0006572)1.59621343
171Slow saccadic eye movements (HP:0000514)1.59327597
172Malnutrition (HP:0004395)1.58720208
173Pancreatic islet-cell hyperplasia (HP:0004510)1.58270588
174Rectal fistula (HP:0100590)1.57902537
175Gastrointestinal infarctions (HP:0005244)1.56693909
176Deep venous thrombosis (HP:0002625)1.54627102
177Increased IgE level (HP:0003212)1.54381050
178Dysmetric saccades (HP:0000641)1.54216321
179Dementia (HP:0000726)1.54120175
180Abnormality of the periventricular white matter (HP:0002518)1.53843296
181Vascular tortuosity (HP:0004948)1.53029790
182Esophageal varix (HP:0002040)1.52478510
183Purpura (HP:0000979)1.52375699
184Turricephaly (HP:0000262)1.51192039
185Rapidly progressive (HP:0003678)1.51100884
186Peripheral demyelination (HP:0011096)1.50822025
187Metaphyseal cupping (HP:0003021)1.50399374
188Syringomyelia (HP:0003396)1.50015374
189Spinal cord lesions (HP:0100561)1.50015374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.55652106
2ERN13.95114414
3GRK53.68764740
4PRPF4B3.12151033
5TYRO32.56735802
6GRK62.50417451
7RIPK42.28833755
8NTRK12.23437459
9IRAK32.17018451
10MAP3K92.15817168
11WNK12.13645544
12RIPK12.10557743
13TGFBR22.00501429
14MAP2K41.83731860
15CSF1R1.78636659
16TYK21.75731003
17TRIB31.75275158
18MAPK71.72389548
19MAP2K31.69210383
20GRK11.63760062
21MATK1.60692546
22BLK1.54415465
23LATS21.52672956
24MAP3K31.52138596
25EPHB11.51024051
26EEF2K1.45838490
27PDGFRA1.44008454
28SMG11.42495987
29CAMK41.41179954
30MARK21.38338493
31PRKD31.37142901
32MAP3K101.35591439
33SIK11.32192539
34MAP3K71.29901044
35FGFR31.29749128
36MAP3K131.29591352
37TAOK21.27273824
38MAP3K141.24650725
39LATS11.23771284
40PAK61.23584393
41NTRK31.21534070
42STK381.21354911
43FGR1.19976747
44ADRBK21.16714786
45MOS1.14597698
46MAP3K11.14078496
47ZAP701.13712268
48KSR21.13420865
49IRAK41.13338504
50JAK11.10022845
51LMTK21.09404379
52PTK21.08555890
53GRK71.08240435
54TTK1.07558947
55CAMK1D1.07418154
56MAP3K111.07259350
57HIPK21.06274106
58PRKG21.04984452
59PDPK11.04543088
60PKN21.02106444
61TBK11.02029924
62MAP3K61.00347381
63ALK0.99977036
64CAMK1G0.96630325
65MTOR0.95705786
66ICK0.94391787
67MAP3K40.94149914
68STK100.93338929
69BMX0.90939439
70TAOK10.90434695
71RPS6KA20.88600064
72AKT30.87163980
73PAK40.86850486
74PAK30.85047602
75MAP3K20.84088897
76DDR20.82647371
77RET0.79706690
78IRAK20.79215667
79JAK30.77943637
80PRKCH0.76873216
81DAPK20.76316941
82ERBB20.75937706
83TTN0.72646664
84EPHA30.71013765
85PTK60.66785084
86CAMKK10.66451976
87NTRK20.63999642
88ADRBK10.63133220
89SIK20.62990446
90MST1R0.61331893
91PRKAA10.60664128
92HCK0.59197823
93RPS6KC10.56762255
94RPS6KL10.56762255
95MAPK120.56218815
96SGK30.55484193
97NEK10.55045147
98CDK60.53465349
99KSR10.52481074
100MINK10.51440870
101CDC42BPA0.50296234
102SGK20.50091217
103AKT20.49422244
104SCYL20.49285793
105PDGFRB0.49262744
106MAPK100.48004711
107IKBKE0.47919663
108DYRK1B0.47822528
109TNK20.46822313
110FYN0.46243890
111PHKG10.45295674
112PHKG20.45295674
113FES0.45109805
114EPHA40.44854331
115SGK2230.44239340
116SGK4940.44239340
117MAP4K10.44084354
118SIK30.42986337
119PDK10.42109776
120FER0.41950068
121RPS6KA30.41073955
122YES10.40401858
123IRAK10.40269605
124MAP2K60.40048460
125MET0.39953667
126NEK60.39575521
127IGF1R0.38561039
128STK110.38408447
129MARK10.37983282
130PRKD20.37130719
131CSK0.37058447
132EPHA20.36896533
133CDK50.35479039
134FGFR20.35216217
135DMPK0.34546733
136INSRR0.33459869
137PDK30.30911190
138PDK40.30911190
139PRKACG0.30351731
140CDK70.29022577
141FGFR40.28995331
142JAK20.28533096
143GSK3A0.28167438
144CSNK1E0.27888084

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.79316849
2Nitrogen metabolism_Homo sapiens_hsa009102.42337378
3Other glycan degradation_Homo sapiens_hsa005112.28511931
4Vitamin B6 metabolism_Homo sapiens_hsa007502.21585937
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20205949
6Osteoclast differentiation_Homo sapiens_hsa043801.99137660
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92820398
8mTOR signaling pathway_Homo sapiens_hsa041501.81552807
9Fructose and mannose metabolism_Homo sapiens_hsa000511.78894721
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76541538
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57228071
12Lysosome_Homo sapiens_hsa041421.52684313
13Staphylococcus aureus infection_Homo sapiens_hsa051501.51627296
14Leishmaniasis_Homo sapiens_hsa051401.50302068
15Prion diseases_Homo sapiens_hsa050201.38859269
16Bile secretion_Homo sapiens_hsa049761.38197665
17Malaria_Homo sapiens_hsa051441.36342856
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35270118
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35264155
20Tuberculosis_Homo sapiens_hsa051521.34803223
21Amoebiasis_Homo sapiens_hsa051461.34250347
22Galactose metabolism_Homo sapiens_hsa000521.34052492
23Acute myeloid leukemia_Homo sapiens_hsa052211.33688920
24TNF signaling pathway_Homo sapiens_hsa046681.30640005
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30259765
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28821247
27Chronic myeloid leukemia_Homo sapiens_hsa052201.25156736
28Arginine biosynthesis_Homo sapiens_hsa002201.24267532
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23714445
30Pertussis_Homo sapiens_hsa051331.22671964
31Dorso-ventral axis formation_Homo sapiens_hsa043201.22444939
32Type II diabetes mellitus_Homo sapiens_hsa049301.22111927
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19147958
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18140518
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.17704735
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17398334
37Notch signaling pathway_Homo sapiens_hsa043301.16208047
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.14891585
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14366922
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.13277589
41Toxoplasmosis_Homo sapiens_hsa051451.12321268
42B cell receptor signaling pathway_Homo sapiens_hsa046621.11729754
43Salmonella infection_Homo sapiens_hsa051321.09161032
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08321855
45Hepatitis C_Homo sapiens_hsa051601.07169803
46Long-term potentiation_Homo sapiens_hsa047201.06286549
47Renal cell carcinoma_Homo sapiens_hsa052111.05862208
48Prolactin signaling pathway_Homo sapiens_hsa049171.05702367
49Lysine degradation_Homo sapiens_hsa003101.05226656
50Influenza A_Homo sapiens_hsa051641.03601094
51African trypanosomiasis_Homo sapiens_hsa051431.03558040
52Insulin resistance_Homo sapiens_hsa049311.03469379
53GABAergic synapse_Homo sapiens_hsa047271.02919265
54Chemokine signaling pathway_Homo sapiens_hsa040621.02286645
55Tryptophan metabolism_Homo sapiens_hsa003801.00430620
56GnRH signaling pathway_Homo sapiens_hsa049120.97817365
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97666107
58Glutamatergic synapse_Homo sapiens_hsa047240.97413893
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.96497749
60Inositol phosphate metabolism_Homo sapiens_hsa005620.95653713
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94627812
62Choline metabolism in cancer_Homo sapiens_hsa052310.94489964
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.93272974
64Glioma_Homo sapiens_hsa052140.92741714
65Insulin secretion_Homo sapiens_hsa049110.92346445
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92260910
67Dilated cardiomyopathy_Homo sapiens_hsa054140.92042839
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89912552
69PPAR signaling pathway_Homo sapiens_hsa033200.89541103
70AMPK signaling pathway_Homo sapiens_hsa041520.89265492
71Salivary secretion_Homo sapiens_hsa049700.87584952
72Phagosome_Homo sapiens_hsa041450.87488335
73Synaptic vesicle cycle_Homo sapiens_hsa047210.85939787
74Hepatitis B_Homo sapiens_hsa051610.85554012
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85361679
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85128081
77Legionellosis_Homo sapiens_hsa051340.84863686
78Ovarian steroidogenesis_Homo sapiens_hsa049130.84830869
79Thyroid cancer_Homo sapiens_hsa052160.84815775
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84699243
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84498865
82Non-small cell lung cancer_Homo sapiens_hsa052230.84125685
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84058404
84Endometrial cancer_Homo sapiens_hsa052130.83358806
85Proteoglycans in cancer_Homo sapiens_hsa052050.82914051
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82568473
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82181264
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80950754
89cAMP signaling pathway_Homo sapiens_hsa040240.80553588
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.80408778
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79108592
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78211736
93Rap1 signaling pathway_Homo sapiens_hsa040150.77142756
94VEGF signaling pathway_Homo sapiens_hsa043700.76860942
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.76395136
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.76260989
97Endocytosis_Homo sapiens_hsa041440.75678337
98Oxytocin signaling pathway_Homo sapiens_hsa049210.75440985
99Renin secretion_Homo sapiens_hsa049240.75155441
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73695279
101Circadian entrainment_Homo sapiens_hsa047130.73670309
102ErbB signaling pathway_Homo sapiens_hsa040120.73431890
103Estrogen signaling pathway_Homo sapiens_hsa049150.71800830
104Adherens junction_Homo sapiens_hsa045200.71786086
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.70874997
106Insulin signaling pathway_Homo sapiens_hsa049100.70586319
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69929895
108Focal adhesion_Homo sapiens_hsa045100.69818221
109Measles_Homo sapiens_hsa051620.69635714
110Gastric acid secretion_Homo sapiens_hsa049710.69553797
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67817768
112Platelet activation_Homo sapiens_hsa046110.67078549
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.66704958
114Complement and coagulation cascades_Homo sapiens_hsa046100.66690436
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66611789
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66294459
117HIF-1 signaling pathway_Homo sapiens_hsa040660.65747267
118Glycerolipid metabolism_Homo sapiens_hsa005610.65575027
119Taste transduction_Homo sapiens_hsa047420.65418888
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65299704
121Dopaminergic synapse_Homo sapiens_hsa047280.65159452
122Apoptosis_Homo sapiens_hsa042100.64651760
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64567124
124Long-term depression_Homo sapiens_hsa047300.63740221
125Glucagon signaling pathway_Homo sapiens_hsa049220.63373511
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.63164791
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62733993
128Protein digestion and absorption_Homo sapiens_hsa049740.62176751
129Hedgehog signaling pathway_Homo sapiens_hsa043400.61780564
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61713761
131Prostate cancer_Homo sapiens_hsa052150.61232705
132Rheumatoid arthritis_Homo sapiens_hsa053230.60150812
133FoxO signaling pathway_Homo sapiens_hsa040680.59766244
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59185661
135Olfactory transduction_Homo sapiens_hsa047400.59068886
136Shigellosis_Homo sapiens_hsa051310.58888194
137Hippo signaling pathway_Homo sapiens_hsa043900.58749292
138ABC transporters_Homo sapiens_hsa020100.58573596
139Vibrio cholerae infection_Homo sapiens_hsa051100.58333967
140Starch and sucrose metabolism_Homo sapiens_hsa005000.58045615
141Basal cell carcinoma_Homo sapiens_hsa052170.57796015
142Melanogenesis_Homo sapiens_hsa049160.57578709
143Pancreatic cancer_Homo sapiens_hsa052120.57327649
144MicroRNAs in cancer_Homo sapiens_hsa052060.57013911
145Bladder cancer_Homo sapiens_hsa052190.56813489
146Gap junction_Homo sapiens_hsa045400.55254936
147MAPK signaling pathway_Homo sapiens_hsa040100.55109083
148Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55021809
149Cholinergic synapse_Homo sapiens_hsa047250.54534691
150Calcium signaling pathway_Homo sapiens_hsa040200.54511050
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54503064
152T cell receptor signaling pathway_Homo sapiens_hsa046600.53989563
153Fatty acid degradation_Homo sapiens_hsa000710.53115448
154Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52805355
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51988872
156Small cell lung cancer_Homo sapiens_hsa052220.51812163

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