ARHGEF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.40382155
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.69833655
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.69833655
4negative regulation of cell killing (GO:0031342)6.64886659
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.64886659
6positive thymic T cell selection (GO:0045059)6.57071067
7regulation of gamma-delta T cell differentiation (GO:0045586)6.48030232
8antigen processing and presentation of endogenous antigen (GO:0019883)6.16102392
9negative T cell selection (GO:0043383)6.07794673
10negative thymic T cell selection (GO:0045060)5.98188049
11regulation of gamma-delta T cell activation (GO:0046643)5.90541096
12positive T cell selection (GO:0043368)5.88104335
13thymic T cell selection (GO:0045061)5.66084727
14regulation of T cell tolerance induction (GO:0002664)5.52974097
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.51116091
16T cell selection (GO:0045058)5.44037171
17response to interleukin-15 (GO:0070672)5.29351767
18tolerance induction (GO:0002507)5.04109987
19leukocyte aggregation (GO:0070486)4.84650605
20regulation of isotype switching to IgG isotypes (GO:0048302)4.80282361
21positive regulation of tolerance induction (GO:0002645)4.79275684
22T cell migration (GO:0072678)4.75425603
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.65906176
24regulation of regulatory T cell differentiation (GO:0045589)4.65248114
25interferon-gamma production (GO:0032609)4.50139779
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.48040443
27positive regulation by organism of defense response of other organism involved in symbiotic interact4.48040443
28modulation by symbiont of host immune response (GO:0052553)4.48040443
29positive regulation by symbiont of host defense response (GO:0052509)4.48040443
30modulation by symbiont of host defense response (GO:0052031)4.48040443
31modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.48040443
32T cell receptor signaling pathway (GO:0050852)4.47458875
33detection of bacterium (GO:0016045)4.44407568
34cellular response to interleukin-15 (GO:0071350)4.42504767
35detection of other organism (GO:0098543)4.39035995
36regulation of B cell receptor signaling pathway (GO:0050855)4.19533523
37regulation of tolerance induction (GO:0002643)4.15467883
38antigen receptor-mediated signaling pathway (GO:0050851)4.14769333
39B cell receptor signaling pathway (GO:0050853)3.99881795
40regulation of interleukin-12 biosynthetic process (GO:0045075)3.97786158
41regulation of B cell differentiation (GO:0045577)3.95660568
42regulation of interleukin-2 biosynthetic process (GO:0045076)3.95383654
43T cell costimulation (GO:0031295)3.94183251
44neutrophil activation involved in immune response (GO:0002283)3.89976324
45lymphocyte costimulation (GO:0031294)3.86605484
46response to muramyl dipeptide (GO:0032495)3.81053962
47positive regulation of interleukin-2 production (GO:0032743)3.76519714
48activated T cell proliferation (GO:0050798)3.75058842
49positive regulation of B cell differentiation (GO:0045579)3.70674386
50macrophage activation involved in immune response (GO:0002281)3.68139246
51negative regulation of T cell mediated immunity (GO:0002710)3.67565641
52T cell homeostasis (GO:0043029)3.66574689
53negative regulation of erythrocyte differentiation (GO:0045647)3.57659011
54positive regulation of histone deacetylation (GO:0031065)3.52787531
55response to peptidoglycan (GO:0032494)3.52435149
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.50081353
57regulation of alpha-beta T cell proliferation (GO:0046640)3.48713273
58NIK/NF-kappaB signaling (GO:0038061)3.45035812
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.44011088
60immunoglobulin mediated immune response (GO:0016064)3.40720175
61leukocyte cell-cell adhesion (GO:0007159)3.38970169
62detection of external biotic stimulus (GO:0098581)3.36727797
63positive regulation of isotype switching (GO:0045830)3.36391195
64JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.34294897
65antigen processing and presentation via MHC class Ib (GO:0002475)3.33902163
66regulation of isotype switching (GO:0045191)3.33005156
67type I interferon signaling pathway (GO:0060337)3.32614497
68cellular response to type I interferon (GO:0071357)3.32614497
69regulation of interferon-beta biosynthetic process (GO:0045357)3.31073428
70regulation of type I interferon-mediated signaling pathway (GO:0060338)3.29639915
71lymphocyte homeostasis (GO:0002260)3.29293901
72positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.26800412
73natural killer cell differentiation (GO:0001779)3.25409722
74germinal center formation (GO:0002467)3.25201727
75negative regulation of lymphocyte mediated immunity (GO:0002707)3.23523302
76negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.23208176
77regulation of T cell receptor signaling pathway (GO:0050856)3.20519814
78respiratory burst (GO:0045730)3.16417803
79immune response-activating cell surface receptor signaling pathway (GO:0002429)3.12659302
80neutrophil activation (GO:0042119)3.12481609
81regulation of interleukin-2 production (GO:0032663)3.10393649
82regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10374469
83negative regulation of innate immune response (GO:0045824)3.08409296
84regulation of response to interferon-gamma (GO:0060330)3.06320842
85regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.05794656
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02516459
87regulation of T cell mediated cytotoxicity (GO:0001914)3.02157433
88regulation of mast cell degranulation (GO:0043304)3.01872926
89myeloid cell activation involved in immune response (GO:0002275)2.99964186
90mannose metabolic process (GO:0006013)2.99223443
91response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98792781
92response to host immune response (GO:0052572)2.98792781
93defense response to protozoan (GO:0042832)2.98478218
94alpha-beta T cell activation (GO:0046631)2.97048610
95histone H3-K4 trimethylation (GO:0080182)2.94045672
96negative regulation of interleukin-12 production (GO:0032695)2.93053039
97detection of biotic stimulus (GO:0009595)2.91884952
98positive regulation of granulocyte differentiation (GO:0030854)2.91703651
99response to host (GO:0075136)2.91285794
100response to host defenses (GO:0052200)2.91285794
101response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91285794
102B cell homeostasis (GO:0001782)2.89089785
103interferon-gamma-mediated signaling pathway (GO:0060333)2.88954858
104mast cell activation (GO:0045576)2.87651977
105T cell differentiation (GO:0030217)2.87368610
106positive regulation of T cell mediated cytotoxicity (GO:0001916)2.86676904
107regulation of myeloid leukocyte mediated immunity (GO:0002886)2.86452372
108negative regulation of T-helper cell differentiation (GO:0045623)2.86099089
109negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.86099089
110negative regulation of phagocytosis (GO:0050765)2.85926072
111regulation of leukocyte degranulation (GO:0043300)2.84525173
112granulocyte activation (GO:0036230)2.82780914
113leukocyte homeostasis (GO:0001776)2.82776348
114natural killer cell activation (GO:0030101)2.81260982
115regulation of granulocyte differentiation (GO:0030852)2.80865757
116negative regulation of glycoprotein biosynthetic process (GO:0010561)2.78737875
117positive regulation of alpha-beta T cell proliferation (GO:0046641)2.78246591
118leukocyte degranulation (GO:0043299)2.77450940
119negative regulation of interleukin-6 production (GO:0032715)2.76989938
120positive regulation of DNA recombination (GO:0045911)2.76858855
121T cell proliferation (GO:0042098)2.76636719
122alpha-beta T cell differentiation (GO:0046632)2.76489915
123regulation of B cell mediated immunity (GO:0002712)2.76483253
124regulation of immunoglobulin mediated immune response (GO:0002889)2.76360767
125signal complex assembly (GO:0007172)2.75854034
126response to protozoan (GO:0001562)2.75820580
127mast cell activation involved in immune response (GO:0002279)2.74653257
128mast cell degranulation (GO:0043303)2.74653257
129positive regulation of T cell differentiation (GO:0045582)2.74481468
130positive regulation of protein deacetylation (GO:0090312)2.73186611
131response to laminar fluid shear stress (GO:0034616)2.73109954
132heterotypic cell-cell adhesion (GO:0034113)2.72744537
133regulation of immunoglobulin production (GO:0002637)2.72350067
134negative regulation of leukocyte mediated immunity (GO:0002704)2.72225199
135regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.67310288
136regulation of natural killer cell mediated immunity (GO:0002715)2.67310288
137positive regulation of humoral immune response (GO:0002922)2.64791725
138negative regulation of B cell mediated immunity (GO:0002713)2.63225843
139negative regulation of immunoglobulin mediated immune response (GO:0002890)2.63225843
140positive regulation of immunoglobulin production (GO:0002639)2.63104791
141regulation of alpha-beta T cell activation (GO:0046634)2.61687089
142cellular extravasation (GO:0045123)2.60592544
143response to type I interferon (GO:0034340)2.60581280
144positive regulation of B cell mediated immunity (GO:0002714)2.60409372
145positive regulation of immunoglobulin mediated immune response (GO:0002891)2.60409372
146histone H3-K4 methylation (GO:0051568)2.60218656
147T cell activation (GO:0042110)2.59690072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.37634273
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.90779315
3MYC_22102868_ChIP-Seq_BL_Human4.33649933
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.71990603
5VDR_21846776_ChIP-Seq_THP-1_Human3.25842359
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.21589755
7* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.09967220
8RUNX_20019798_ChIP-Seq_JUKART_Human3.08596147
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.05099234
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00182497
11E2F7_22180533_ChIP-Seq_HELA_Human2.98006837
12MAF_26560356_Chip-Seq_TH1_Human2.90943498
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82693857
14MYB_26560356_Chip-Seq_TH2_Human2.80190951
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.77760294
16* UTX_26944678_Chip-Seq_JUKART_Human2.71021353
17* TCF7_22412390_ChIP-Seq_EML_Mouse2.58160938
18MYB_26560356_Chip-Seq_TH1_Human2.57755012
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.46797513
20KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.43067667
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42874533
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.37510889
23* KDM2B_26808549_Chip-Seq_DND41_Human2.30345900
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.28956197
25SCL_19346495_ChIP-Seq_HPC-7_Human2.23491876
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22089879
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18195363
28VDR_24763502_ChIP-Seq_THP-1_Human2.16664389
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.15939727
30KDM2B_26808549_Chip-Seq_SUP-B15_Human2.12651043
31IRF8_21731497_ChIP-ChIP_J774_Mouse2.10054702
32* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05699334
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.03468249
34MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01471463
35* MAF_26560356_Chip-Seq_TH2_Human1.99604092
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.98145277
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92351963
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90666081
39* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90113235
40* ELK3_25401928_ChIP-Seq_HUVEC_Human1.87046994
41SPI1_23547873_ChIP-Seq_NB4_Human1.81457984
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75526641
43GATA3_27048872_Chip-Seq_THYMUS_Human1.74205197
44SPI1_23127762_ChIP-Seq_K562_Human1.68523887
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.68465690
46* CIITA_25753668_ChIP-Seq_RAJI_Human1.67366379
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51213480
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.49069491
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.45252896
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43725543
51* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43361821
52* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37525620
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36967147
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36325823
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28140926
56RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27628420
57LXR_22292898_ChIP-Seq_THP-1_Human1.26238643
58NCOR1_26117541_ChIP-Seq_K562_Human1.25430739
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25270344
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23046112
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21197314
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.21092002
63BCOR_27268052_Chip-Seq_Bcells_Human1.20320169
64PU_27001747_Chip-Seq_BMDM_Mouse1.18523233
65VDR_24787735_ChIP-Seq_THP-1_Human1.15889287
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15787981
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15696328
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.13501083
69* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10916997
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10757857
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09406622
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09045370
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08940980
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08416095
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06285269
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06210403
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05698921
78KDM2B_26808549_Chip-Seq_K562_Human1.04043197
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02033310
80* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99773049
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98584892
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98203685
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98005987
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97282307
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97217666
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96705742
87GATA1_19941826_ChIP-Seq_K562_Human0.95581167
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94996939
89GATA3_26560356_Chip-Seq_TH2_Human0.94504775
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92341191
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.92100146
92* RACK7_27058665_Chip-Seq_MCF-7_Human0.92025913
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91889242
94SMC4_20622854_ChIP-Seq_HELA_Human0.91651625
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90928017
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90592448
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90316687
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90016621
99SMAD_19615063_ChIP-ChIP_OVARY_Human0.89551484
100* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89544557
101* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89110702
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88266828
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85645887
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84433570
105P68_20966046_ChIP-Seq_HELA_Human0.84281235
106CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82376411
107* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82047371
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81861974
109GATA2_19941826_ChIP-Seq_K562_Human0.81807595
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81277777
111SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.80124505
112SA1_27219007_Chip-Seq_ERYTHROID_Human0.79427784
113SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79426475
114BCL6_27268052_Chip-Seq_Bcells_Human0.79089952
115CTCF_21964334_Chip-Seq_Bcells_Human0.78071354
116ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77858110
117P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77645359
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.77583067
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75425231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.54203969
2MP0000685_abnormal_immune_system3.62143796
3MP0005387_immune_system_phenotype3.30422663
4MP0001790_abnormal_immune_system3.30422663
5MP0001835_abnormal_antigen_presentation3.26174307
6* MP0001800_abnormal_humoral_immune3.21414022
7MP0005671_abnormal_response_to3.11431182
8MP0002396_abnormal_hematopoietic_system2.79028179
9MP0001873_stomach_inflammation2.78376386
10MP0003303_peritoneal_inflammation2.72274090
11* MP0002398_abnormal_bone_marrow2.68382626
12MP0005000_abnormal_immune_tolerance2.67672999
13* MP0002420_abnormal_adaptive_immunity2.64813395
14MP0003300_gastrointestinal_ulcer2.63086829
15* MP0002723_abnormal_immune_serum2.60664344
16* MP0001819_abnormal_immune_cell2.60135458
17* MP0002452_abnormal_antigen_presenting2.59919754
18MP0003436_decreased_susceptibility_to2.46490099
19MP0002166_altered_tumor_susceptibility2.43158429
20MP0000703_abnormal_thymus_morphology2.38898442
21* MP0000716_abnormal_immune_system2.33665987
22MP0002405_respiratory_system_inflammati2.28596065
23MP0004947_skin_inflammation2.28019981
24MP0009333_abnormal_splenocyte_physiolog2.21188133
25* MP0002722_abnormal_immune_system2.19039102
26* MP0000689_abnormal_spleen_morphology2.18688283
27MP0005025_abnormal_response_to2.17359761
28MP0003866_abnormal_defecation2.15150025
29MP0010155_abnormal_intestine_physiology2.10469653
30MP0004808_abnormal_hematopoietic_stem2.08014957
31MP0009278_abnormal_bone_marrow2.02598855
32MP0009785_altered_susceptibility_to1.96342670
33MP0005464_abnormal_platelet_physiology1.94283696
34* MP0002429_abnormal_blood_cell1.92953697
35MP0000465_gastrointestinal_hemorrhage1.92646821
36MP0008260_abnormal_autophagy1.91264597
37MP0002006_tumorigenesis1.83988346
38* MP0002419_abnormal_innate_immunity1.82536723
39MP0004510_myositis1.80444154
40MP0006082_CNS_inflammation1.68523015
41MP0002933_joint_inflammation1.65672651
42MP0001845_abnormal_inflammatory_respons1.61362518
43MP0002148_abnormal_hypersensitivity_rea1.60390663
44MP0005451_abnormal_body_composition1.59210004
45MP0001545_abnormal_hematopoietic_system1.52732019
46MP0005397_hematopoietic_system_phenotyp1.52732019
47MP0010352_gastrointestinal_tract_polyps1.49839568
48MP0001853_heart_inflammation1.47476935
49MP0003724_increased_susceptibility_to1.43317877
50MP0008961_abnormal_basal_metabolism1.42436886
51MP0000490_abnormal_crypts_of1.27662676
52MP0005076_abnormal_cell_differentiation1.23693250
53MP0001851_eye_inflammation1.20345524
54MP0005310_abnormal_salivary_gland1.19251610
55MP0000858_altered_metastatic_potential1.17574266
56MP0005023_abnormal_wound_healing1.15230139
57MP0001533_abnormal_skeleton_physiology1.12063723
58MP0003566_abnormal_cell_adhesion1.08382541
59MP0005174_abnormal_tail_pigmentation1.07242595
60MP0004883_abnormal_blood_vessel1.04673269
61MP0008469_abnormal_protein_level1.02965302
62MP0002019_abnormal_tumor_incidence1.00878048
63MP0003448_altered_tumor_morphology0.98657379
64MP0004185_abnormal_adipocyte_glucose0.97626615
65MP0003045_fibrosis0.89193422
66MP0005390_skeleton_phenotype0.84168851
67MP0001986_abnormal_taste_sensitivity0.84131949
68MP0003690_abnormal_glial_cell0.82000276
69MP0005166_decreased_susceptibility_to0.81551461
70MP0003091_abnormal_cell_migration0.81412377
71MP0003453_abnormal_keratinocyte_physiol0.79561710
72MP0005075_abnormal_melanosome_morpholog0.78560345
73MP0000569_abnormal_digit_pigmentation0.78086019
74MP0003191_abnormal_cellular_cholesterol0.77547928
75MP0003172_abnormal_lysosome_physiology0.77143754
76MP0002277_abnormal_respiratory_mucosa0.75407139
77MP0003077_abnormal_cell_cycle0.74937596
78MP0003279_aneurysm0.74215193
79MP0005164_abnormal_response_to0.72695235
80MP0003705_abnormal_hypodermis_morpholog0.72066497
81MP0002138_abnormal_hepatobiliary_system0.71954637
82MP0002998_abnormal_bone_remodeling0.71914475
83MP0005670_abnormal_white_adipose0.68440174
84MP0002132_abnormal_respiratory_system0.68228212
85MP0001348_abnormal_lacrimal_gland0.67567870
86MP0003075_altered_response_to0.67524988
87MP0001663_abnormal_digestive_system0.67202283
88MP0000609_abnormal_liver_physiology0.66263420
89MP0005058_abnormal_lysosome_morphology0.65528579
90MP0003828_pulmonary_edema0.65336161
91MP0004381_abnormal_hair_follicle0.64518966
92MP0009763_increased_sensitivity_to0.63120501
93MP0000477_abnormal_intestine_morphology0.62561189
94MP0004130_abnormal_muscle_cell0.62253217
95MP0000604_amyloidosis0.62100183
96MP0000733_abnormal_muscle_development0.61592859
97MP0002136_abnormal_kidney_physiology0.60896367
98MP0001243_abnormal_dermal_layer0.60240961
99MP0010307_abnormal_tumor_latency0.58920402
100MP0008004_abnormal_stomach_pH0.57803743
101MP0001216_abnormal_epidermal_layer0.56460379
102MP0001958_emphysema0.56175192
103MP0005381_digestive/alimentary_phenotyp0.55768506
104MP0000350_abnormal_cell_proliferation0.53752974
105MP0000015_abnormal_ear_pigmentation0.53702666
106MP0009931_abnormal_skin_appearance0.52752639
107MP0009764_decreased_sensitivity_to0.52690881
108MP0000313_abnormal_cell_death0.51530577
109MP0003693_abnormal_embryo_hatching0.50839769
110MP0003183_abnormal_peptide_metabolism0.50471685
111MP0003795_abnormal_bone_structure0.50459599
112MP0002009_preneoplasia0.49881477
113MP0001849_ear_inflammation0.49635305
114MP0000249_abnormal_blood_vessel0.49446502
115MP0009115_abnormal_fat_cell0.49060211
116MP0008057_abnormal_DNA_replication0.48715496
117MP0009840_abnormal_foam_cell0.48615891
118MP0005666_abnormal_adipose_tissue0.48445631

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.46781981
2Abnormality of T cell number (HP:0011839)5.17018319
3Panhypogammaglobulinemia (HP:0003139)4.74266497
4Abnormality of the fingertips (HP:0001211)4.65381570
5Chronic otitis media (HP:0000389)4.58992879
6Recurrent viral infections (HP:0004429)4.56513089
7Abnormality of macrophages (HP:0004311)4.48801364
8Recurrent bronchitis (HP:0002837)4.38776774
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.38235520
10Recurrent fungal infections (HP:0002841)4.34986072
11Pustule (HP:0200039)4.33738038
12Nasal polyposis (HP:0100582)4.22503426
13Abnormality of T cells (HP:0002843)4.13362439
14IgM deficiency (HP:0002850)4.07020331
15Orchitis (HP:0100796)4.00789342
16Elevated erythrocyte sedimentation rate (HP:0003565)3.82297022
17Optic neuritis (HP:0100653)3.74708107
18Retrobulbar optic neuritis (HP:0100654)3.74708107
19Abnormality of the nasal mucosa (HP:0000433)3.74022933
20Recurrent gram-negative bacterial infections (HP:0005420)3.72636716
21Autoimmune thrombocytopenia (HP:0001973)3.70923871
22Agammaglobulinemia (HP:0004432)3.68953098
23Eczematoid dermatitis (HP:0000976)3.60447954
24Recurrent cutaneous fungal infections (HP:0011370)3.57875359
25Chronic mucocutaneous candidiasis (HP:0002728)3.57875359
26Severe combined immunodeficiency (HP:0004430)3.57016076
27Inflammation of the large intestine (HP:0002037)3.53934879
28Gastrointestinal inflammation (HP:0004386)3.50180800
29Papilloma (HP:0012740)3.49828027
30Verrucae (HP:0200043)3.49828027
31Combined immunodeficiency (HP:0005387)3.49386278
32Stomatitis (HP:0010280)3.35058110
33Colitis (HP:0002583)3.22964052
34B lymphocytopenia (HP:0010976)3.11469778
35Abnormality of B cell number (HP:0010975)3.11469778
36Spontaneous hematomas (HP:0007420)3.09927547
37Cellulitis (HP:0100658)3.05459016
38Lymphopenia (HP:0001888)3.03330461
39Meningitis (HP:0001287)3.01927398
40Eosinophilia (HP:0001880)3.01597697
41Autoimmune hemolytic anemia (HP:0001890)2.98061641
42Recurrent abscess formation (HP:0002722)2.97451873
43Abnormality of T cell physiology (HP:0011840)2.95710548
44Thyroiditis (HP:0100646)2.95222961
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.92857690
46Prolonged bleeding time (HP:0003010)2.91080300
47Increased IgE level (HP:0003212)2.88252240
48IgG deficiency (HP:0004315)2.77564172
49Myositis (HP:0100614)2.76636653
50Abnormality of eosinophils (HP:0001879)2.75923830
51Basal cell carcinoma (HP:0002671)2.74476373
52Keratoconjunctivitis sicca (HP:0001097)2.73704385
53Granulocytopenia (HP:0001913)2.72809308
54Urticaria (HP:0001025)2.71600412
55Leukocytosis (HP:0001974)2.69360557
56Chronic sinusitis (HP:0011109)2.61582160
57Emphysema (HP:0002097)2.61298793
58Hypochromic anemia (HP:0001931)2.57636832
59Recurrent skin infections (HP:0001581)2.55513107
60Papilledema (HP:0001085)2.55199296
61Vasculitis (HP:0002633)2.52804952
62Recurrent bacterial skin infections (HP:0005406)2.52693355
63Recurrent sinusitis (HP:0011108)2.52130710
64Chronic diarrhea (HP:0002028)2.51300081
65Keratoconjunctivitis (HP:0001096)2.49038130
66Gastrointestinal stroma tumor (HP:0100723)2.45348803
67Mediastinal lymphadenopathy (HP:0100721)2.44948594
68Increased IgM level (HP:0003496)2.40077994
69Bronchitis (HP:0012387)2.38380132
70Cerebral aneurysm (HP:0004944)2.38056161
71IgA deficiency (HP:0002720)2.35667351
72Increased density of long bones (HP:0006392)2.31291830
73Abnormal platelet volume (HP:0011876)2.31227453
74Epistaxis (HP:0000421)2.29109682
75Thrombocytosis (HP:0001894)2.25187730
76Aortic aneurysm (HP:0004942)2.24935855
77Pulmonary embolism (HP:0002204)2.24918525
78Slow saccadic eye movements (HP:0000514)2.24485407
79Viral hepatitis (HP:0006562)2.23431362
80Episodic fever (HP:0001954)2.21255631
81Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19015942
82Petechiae (HP:0000967)2.15294439
83Arterial thrombosis (HP:0004420)2.14715056
84Obstructive sleep apnea (HP:0002870)2.14128251
85Hypoplasia of the thymus (HP:0000778)2.14055276
86Ureteral stenosis (HP:0000071)2.13517337
87Lymphoma (HP:0002665)2.13246088
88Chest pain (HP:0100749)2.12883464
89Hypochromic microcytic anemia (HP:0004840)2.09158619
90Periodontitis (HP:0000704)2.08331081
91Chronic obstructive pulmonary disease (HP:0006510)2.07197266
92Obstructive lung disease (HP:0006536)2.07197266
93Skin ulcer (HP:0200042)2.06533800
94Joint swelling (HP:0001386)2.04577181
95Recurrent otitis media (HP:0000403)2.02115457
96Abnormal platelet function (HP:0011869)2.01839456
97Impaired platelet aggregation (HP:0003540)2.01839456
98Hemoptysis (HP:0002105)2.00248405
99Hyperacusis (HP:0010780)2.00183199
100Anorexia (HP:0002039)2.00172479
101Interstitial pulmonary disease (HP:0006530)1.99632128
102Premature loss of primary teeth (HP:0006323)1.98582916
103Broad face (HP:0000283)1.94652935
104Abnormality of the pleura (HP:0002103)1.94506566
105Cheilitis (HP:0100825)1.93813735
106Gingival bleeding (HP:0000225)1.93434158
107Bicuspid aortic valve (HP:0001647)1.93128223
108Ureteral obstruction (HP:0006000)1.92764453
109Polygenic inheritance (HP:0010982)1.91229157
110Restrictive lung disease (HP:0002091)1.91060648
111Encephalitis (HP:0002383)1.90874865
112Purpura (HP:0000979)1.90590691
113Frequent falls (HP:0002359)1.90089770
114Hematochezia (HP:0002573)1.89158590
115Increased serum ferritin (HP:0003281)1.88943293
116Seborrheic dermatitis (HP:0001051)1.87860870
117Broad palm (HP:0001169)1.87708921
118Villous atrophy (HP:0011473)1.86677246
119Abnormality of small intestinal villus morphology (HP:0011472)1.86677246
120Microcytic anemia (HP:0001935)1.85066765
121Glomerulopathy (HP:0100820)1.85033441
122Dysostosis multiplex (HP:0000943)1.84630137
123Gingivitis (HP:0000230)1.83036238
124Increased mean platelet volume (HP:0011877)1.82495287
125Abnormality of the peritoneum (HP:0002585)1.80890173
126Peritonitis (HP:0002586)1.79188538
127Macroorchidism (HP:0000053)1.77207970
128Sepsis (HP:0100806)1.76890654
129Pulmonary infiltrates (HP:0002113)1.76811619
130Hepatitis (HP:0012115)1.75311679
131Osteomyelitis (HP:0002754)1.75157747
132Gastrointestinal infarctions (HP:0005244)1.75008326
133Hypergammaglobulinemia (HP:0010702)1.74647302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.73921231
2PRPF4B3.56205446
3TXK3.12098147
4MAP3K103.07182727
5STK102.79196774
6JAK32.77755607
7EEF2K2.70484823
8GRK62.63888901
9TYK22.54366238
10ZAP702.52543107
11FGFR42.46863625
12ITK2.37142944
13TRIB32.05234096
14SIK22.04488494
15PKN21.97741822
16MAP3K131.90621544
17IKBKE1.88019368
18JAK11.79984225
19CDK121.77781868
20ERN11.66384354
21BTK1.63500025
22FGFR31.63350448
23LCK1.62504411
24SMG11.56210739
25MAP3K141.52922267
26HCK1.51003366
27LRRK21.47671760
28NLK1.46837611
29SYK1.46751994
30MARK31.46106964
31CSK1.45890279
32TTN1.36335629
33BLK1.34958159
34TBK11.34328929
35MAP3K31.28049030
36EPHB11.25909350
37PRKCH1.24667158
38TGFBR21.23953759
39MAP3K71.17143545
40MAP3K111.17039788
41CDC42BPA1.12767044
42TEC1.12682744
43CSF1R1.08948344
44MAP2K31.07604948
45KIT1.07168788
46PTK61.05777105
47SIK11.05337901
48IRAK41.04445089
49MAP3K11.02209190
50FGR1.01411808
51CLK10.99216785
52FES0.98096709
53RPS6KA40.97239358
54PIM10.95317302
55PRKCQ0.92353678
56IKBKB0.91640312
57PRKD20.88385777
58KDR0.87360161
59CAMKK10.86393082
60PASK0.84971499
61CDK40.83817344
62BRD40.83217875
63TNK20.82040659
64KSR20.81662223
65NEK20.80260062
66TAOK10.78610681
67CHUK0.78503875
68MARK20.76799636
69PDGFRB0.74880145
70TAOK20.70970579
71ALK0.70773211
72LYN0.70233913
73SIK30.70050804
74ICK0.68231632
75CAMK1G0.67856342
76HIPK20.67791596
77TYRO30.66307141
78PDPK10.65609261
79FLT30.63918611
80YES10.62497499
81STK40.61952418
82TESK20.59934518
83MAP3K60.58332133
84* JAK20.55979308
85RPS6KL10.55877949
86RPS6KC10.55877949
87MAPK120.55517579
88IRAK10.55234344
89CAMK1D0.54464846
90CDK60.54408998
91RIPK40.54227947
92TRPM70.53618794
93FGFR20.53316301
94PDK10.53089680
95MST40.52761618
96MAP2K20.51138472
97MAPK70.50743247
98IRAK30.50474355
99NME20.50381123
100IRAK20.50143032
101EPHA30.49315847
102CAMKK20.48725369
103STK380.48074548
104DYRK1B0.46457495
105MELK0.46357034
106BMX0.44925601
107BMPR20.43938571
108MTOR0.43779582
109DMPK0.41553128
110RPS6KB20.40271631
111CDK90.40167025
112MAPK110.39859714
113MAP3K80.39740670
114TAOK30.38412899
115SGK30.37636735
116MAPK40.37102115
117PTK2B0.35887928
118STK110.35198285
119MAP2K60.35184767
120MAPKAPK20.34703066
121RPS6KA60.33840789
122FYN0.32831923
123PRKD10.32498825
124INSR0.31858101
125EGFR0.31400140
126RIPK10.31004023
127ABL10.27793179
128RET0.27561045
129PDGFRA0.27558498

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.08162030
2T cell receptor signaling pathway_Homo sapiens_hsa046603.17627995
3B cell receptor signaling pathway_Homo sapiens_hsa046622.84626689
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.44276333
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.32628476
6Measles_Homo sapiens_hsa051622.29931241
7Osteoclast differentiation_Homo sapiens_hsa043802.26147729
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20113826
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.18185370
10Leishmaniasis_Homo sapiens_hsa051402.10290776
11Hematopoietic cell lineage_Homo sapiens_hsa046402.08105497
12Antigen processing and presentation_Homo sapiens_hsa046122.07306674
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.91514023
14Acute myeloid leukemia_Homo sapiens_hsa052211.81923158
15Type I diabetes mellitus_Homo sapiens_hsa049401.69053947
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67952527
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.61844162
18Chronic myeloid leukemia_Homo sapiens_hsa052201.61748568
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.60669544
20Viral myocarditis_Homo sapiens_hsa054161.57470408
21Herpes simplex infection_Homo sapiens_hsa051681.53539499
22Toxoplasmosis_Homo sapiens_hsa051451.51917677
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48575585
24Chemokine signaling pathway_Homo sapiens_hsa040621.48165201
25Hepatitis B_Homo sapiens_hsa051611.40199381
26Pancreatic cancer_Homo sapiens_hsa052121.33850288
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31907639
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31258619
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25540776
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23178997
31Influenza A_Homo sapiens_hsa051641.22703793
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19893556
33Shigellosis_Homo sapiens_hsa051311.19847526
34* Platelet activation_Homo sapiens_hsa046111.17308095
35HTLV-I infection_Homo sapiens_hsa051661.16958603
36Apoptosis_Homo sapiens_hsa042101.13317254
37Non-small cell lung cancer_Homo sapiens_hsa052231.12438143
38TNF signaling pathway_Homo sapiens_hsa046681.11551052
39Lysine degradation_Homo sapiens_hsa003101.11072914
40Colorectal cancer_Homo sapiens_hsa052101.10716129
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09762682
42VEGF signaling pathway_Homo sapiens_hsa043701.08794544
43Staphylococcus aureus infection_Homo sapiens_hsa051501.08454402
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.04998011
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04829869
46Allograft rejection_Homo sapiens_hsa053301.02631956
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01339856
48Notch signaling pathway_Homo sapiens_hsa043301.00374887
49Small cell lung cancer_Homo sapiens_hsa052220.95570504
50Tuberculosis_Homo sapiens_hsa051520.95431431
51Prolactin signaling pathway_Homo sapiens_hsa049170.94845291
52Hepatitis C_Homo sapiens_hsa051600.93672937
53Epstein-Barr virus infection_Homo sapiens_hsa051690.91956876
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90395182
55Graft-versus-host disease_Homo sapiens_hsa053320.88649602
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87505793
57Insulin resistance_Homo sapiens_hsa049310.85585658
58Viral carcinogenesis_Homo sapiens_hsa052030.82830422
59Malaria_Homo sapiens_hsa051440.82665259
60African trypanosomiasis_Homo sapiens_hsa051430.82620564
61mTOR signaling pathway_Homo sapiens_hsa041500.81855081
62Phagosome_Homo sapiens_hsa041450.81514443
63Pertussis_Homo sapiens_hsa051330.76566645
64GnRH signaling pathway_Homo sapiens_hsa049120.75818009
65FoxO signaling pathway_Homo sapiens_hsa040680.72669363
66Endometrial cancer_Homo sapiens_hsa052130.70888506
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69641300
68Rheumatoid arthritis_Homo sapiens_hsa053230.68084893
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67213068
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66986993
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66841354
72Salmonella infection_Homo sapiens_hsa051320.65662473
73Renal cell carcinoma_Homo sapiens_hsa052110.64835967
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63952337
75Inositol phosphate metabolism_Homo sapiens_hsa005620.63671631
76Legionellosis_Homo sapiens_hsa051340.62948487
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.62452463
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61986087
79Prostate cancer_Homo sapiens_hsa052150.61806939
80* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60356096
81Autoimmune thyroid disease_Homo sapiens_hsa053200.60246212
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.58977594
83Endocytosis_Homo sapiens_hsa041440.58733281
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58596634
85Other glycan degradation_Homo sapiens_hsa005110.58384807
86MAPK signaling pathway_Homo sapiens_hsa040100.58363424
87ErbB signaling pathway_Homo sapiens_hsa040120.57623665
88Choline metabolism in cancer_Homo sapiens_hsa052310.57037666
89Rap1 signaling pathway_Homo sapiens_hsa040150.55729561
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.54742147
91MicroRNAs in cancer_Homo sapiens_hsa052060.54111382
92* Proteoglycans in cancer_Homo sapiens_hsa052050.53253518
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51377049
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.51352903
95Lysosome_Homo sapiens_hsa041420.51048567
96Spliceosome_Homo sapiens_hsa030400.49963321
97Focal adhesion_Homo sapiens_hsa045100.48377247
98p53 signaling pathway_Homo sapiens_hsa041150.47867774
99Glioma_Homo sapiens_hsa052140.47267939
100Amoebiasis_Homo sapiens_hsa051460.47242783
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47201007
102Thyroid cancer_Homo sapiens_hsa052160.47085647
103HIF-1 signaling pathway_Homo sapiens_hsa040660.46843492
104Base excision repair_Homo sapiens_hsa034100.46686017
105Non-homologous end-joining_Homo sapiens_hsa034500.46668800
106Adherens junction_Homo sapiens_hsa045200.45436877
107ABC transporters_Homo sapiens_hsa020100.44983107
108Estrogen signaling pathway_Homo sapiens_hsa049150.44657603
109Insulin signaling pathway_Homo sapiens_hsa049100.43959449
110mRNA surveillance pathway_Homo sapiens_hsa030150.43951651
111* Pathways in cancer_Homo sapiens_hsa052000.43792457
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.42918553
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41950864
114Asthma_Homo sapiens_hsa053100.41185382
115Dorso-ventral axis formation_Homo sapiens_hsa043200.39221596
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38503375
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37070418
118Type II diabetes mellitus_Homo sapiens_hsa049300.36979111

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