ARHGDIG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.43982084
2cellular potassium ion homeostasis (GO:0030007)5.36989661
3synaptic vesicle exocytosis (GO:0016079)5.34821363
4glutamate secretion (GO:0014047)4.91702353
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.90655252
6sodium ion export (GO:0071436)4.81728556
7neuron cell-cell adhesion (GO:0007158)4.79046298
8regulation of synaptic vesicle exocytosis (GO:2000300)4.72880109
9synaptic vesicle maturation (GO:0016188)4.72708277
10vocalization behavior (GO:0071625)4.65009055
11protein localization to synapse (GO:0035418)4.49700714
12neurotransmitter secretion (GO:0007269)4.35634579
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.28998455
14neuronal action potential propagation (GO:0019227)4.28658584
15positive regulation of dendritic spine development (GO:0060999)4.27699346
16neurotransmitter-gated ion channel clustering (GO:0072578)4.14690215
17L-amino acid import (GO:0043092)4.14205908
18regulation of synaptic vesicle transport (GO:1902803)4.13040467
19regulation of voltage-gated calcium channel activity (GO:1901385)4.12380039
20central nervous system myelination (GO:0022010)4.12210455
21axon ensheathment in central nervous system (GO:0032291)4.12210455
22neuronal ion channel clustering (GO:0045161)4.08247643
23gamma-aminobutyric acid transport (GO:0015812)4.06764721
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.03542045
25cerebellar granule cell differentiation (GO:0021707)4.01416341
26locomotory exploration behavior (GO:0035641)3.99648374
27regulation of glutamate receptor signaling pathway (GO:1900449)3.95006327
28proline transport (GO:0015824)3.92040401
29negative regulation of microtubule polymerization (GO:0031115)3.89555456
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.88966853
31exploration behavior (GO:0035640)3.84338655
32layer formation in cerebral cortex (GO:0021819)3.79252646
33potassium ion homeostasis (GO:0055075)3.78202363
34regulation of dendritic spine morphogenesis (GO:0061001)3.75627551
35positive regulation of dendritic spine morphogenesis (GO:0061003)3.73755635
36digestion (GO:0007586)3.73107493
37regulation of synapse maturation (GO:0090128)3.72718991
38potassium ion import (GO:0010107)3.68052625
39neuron recognition (GO:0008038)3.66245823
40regulation of dendritic spine development (GO:0060998)3.60506515
41auditory behavior (GO:0031223)3.59753197
42calcium-mediated signaling using intracellular calcium source (GO:0035584)3.58672052
43neurotransmitter transport (GO:0006836)3.57957840
44amino acid import (GO:0043090)3.57718905
45dendritic spine organization (GO:0097061)3.57196271
46activation of protein kinase A activity (GO:0034199)3.52278611
47cell migration in hindbrain (GO:0021535)3.46771159
48regulation of neuronal synaptic plasticity (GO:0048168)3.45251356
49synaptic transmission, glutamatergic (GO:0035249)3.42941408
50neuromuscular process controlling balance (GO:0050885)3.41720389
51regulation of vesicle fusion (GO:0031338)3.41557636
52neuromuscular process controlling posture (GO:0050884)3.41481543
53membrane depolarization (GO:0051899)3.41322921
54regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.41212864
55positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.39197749
56regulation of neurotransmitter levels (GO:0001505)3.39074358
57neurofilament cytoskeleton organization (GO:0060052)3.38401297
58neuron-neuron synaptic transmission (GO:0007270)3.34532999
59regulation of long-term neuronal synaptic plasticity (GO:0048169)3.32395392
60axonal fasciculation (GO:0007413)3.28287826
61regulation of synaptic transmission (GO:0050804)3.27077201
62acidic amino acid transport (GO:0015800)3.25533664
63ionotropic glutamate receptor signaling pathway (GO:0035235)3.23100661
64response to pheromone (GO:0019236)3.20269590
65positive regulation of synapse maturation (GO:0090129)3.17851539
66regulation of synapse structural plasticity (GO:0051823)3.14990469
67mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.14061478
68neurotransmitter uptake (GO:0001504)3.13388182
69glutamate receptor signaling pathway (GO:0007215)3.12976642
70regulation of ARF protein signal transduction (GO:0032012)3.12381695
71cellular sodium ion homeostasis (GO:0006883)3.11950298
72cell communication by electrical coupling (GO:0010644)3.11537310
73vesicle docking involved in exocytosis (GO:0006904)3.11284320
74negative regulation of dendrite morphogenesis (GO:0050774)3.10372196
75intestinal cholesterol absorption (GO:0030299)3.08246931
76regulation of neurotransmitter secretion (GO:0046928)3.06827743
77exocrine pancreas development (GO:0031017)3.03853298
78serotonin metabolic process (GO:0042428)3.03673092
79dendritic spine morphogenesis (GO:0060997)3.03555433
80mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.03314724
81acid secretion (GO:0046717)3.01030398
82dicarboxylic acid transport (GO:0006835)3.00636679
83synaptic vesicle endocytosis (GO:0048488)3.00119184
84cell differentiation in hindbrain (GO:0021533)2.99064465
85postsynaptic membrane organization (GO:0001941)2.98879086
86signal release (GO:0023061)2.98672788
87regulation of exocytosis (GO:0017157)2.98481657
88chemosensory behavior (GO:0007635)2.98431573
89gamma-aminobutyric acid signaling pathway (GO:0007214)2.96628143
90long-term synaptic potentiation (GO:0060291)2.96567928
91presynaptic membrane organization (GO:0097090)2.96109980
92behavioral response to cocaine (GO:0048148)2.94333795
93regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.94181874
94positive regulation of neurotransmitter transport (GO:0051590)2.94067101
95mating behavior (GO:0007617)2.94012976
96regulation of glutamate secretion (GO:0014048)2.93560912
97positive regulation of neurotransmitter secretion (GO:0001956)2.91286468
98energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91278815
99ATP hydrolysis coupled proton transport (GO:0015991)2.91278815
100energy coupled proton transport, down electrochemical gradient (GO:0015985)2.90246063
101ATP synthesis coupled proton transport (GO:0015986)2.90246063
102synapse assembly (GO:0007416)2.88971336
103long-term memory (GO:0007616)2.87387507
104positive regulation of membrane potential (GO:0045838)2.86864292
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.86226937
106transmission of nerve impulse (GO:0019226)2.85217056
107regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85113903
108regulation of postsynaptic membrane potential (GO:0060078)2.85090041
109synaptic vesicle transport (GO:0048489)2.84452169
110establishment of synaptic vesicle localization (GO:0097480)2.84452169
111positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.84214180
112innervation (GO:0060384)2.83374324
113positive regulation of potassium ion transmembrane transport (GO:1901381)2.83225792
114organelle transport along microtubule (GO:0072384)2.83140828
115axon cargo transport (GO:0008088)2.82681394
116calcium ion-dependent exocytosis (GO:0017156)2.82220608
117regulation of protein kinase A signaling (GO:0010738)2.82200376
118regulation of neurotransmitter transport (GO:0051588)2.81047256
119vesicle transport along microtubule (GO:0047496)2.79096792
120neuromuscular synaptic transmission (GO:0007274)2.78127993
121membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.78070361
122cerebellar Purkinje cell differentiation (GO:0021702)2.77314433
123intraspecies interaction between organisms (GO:0051703)2.76492279
124social behavior (GO:0035176)2.76492279
125regulation of synaptic plasticity (GO:0048167)2.76345868
126cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.75961617
127protein retention in ER lumen (GO:0006621)2.75707511
128detection of temperature stimulus involved in sensory perception (GO:0050961)2.75133222
129detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.75133222
130G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.72610713
131synaptic transmission (GO:0007268)2.72079867
132establishment of vesicle localization (GO:0051650)2.71951376
133cerebellum development (GO:0021549)2.70538097
134negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69089979
135detection of calcium ion (GO:0005513)2.68344293
136membrane depolarization during action potential (GO:0086010)2.65792097
137regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65699355
138cerebellar Purkinje cell layer development (GO:0021680)2.65249133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.68448135
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.21518786
3REST_21632747_ChIP-Seq_MESCs_Mouse3.06253528
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05786242
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02251019
6GBX2_23144817_ChIP-Seq_PC3_Human2.98225831
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87480283
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75537039
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64974645
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64974645
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50813886
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.47482873
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45734437
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.45186534
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.40776554
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38644356
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35147748
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30803560
19TAF15_26573619_Chip-Seq_HEK293_Human2.29996150
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.27907799
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27419139
22ERG_21242973_ChIP-ChIP_JURKAT_Human2.21860320
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.17441502
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10708227
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.06071678
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02659993
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.01163071
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98728031
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.98083971
30ZNF274_21170338_ChIP-Seq_K562_Hela1.92781481
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87124698
32DROSHA_22980978_ChIP-Seq_HELA_Human1.79071593
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79052209
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77686155
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77061112
36AR_21572438_ChIP-Seq_LNCaP_Human1.74358594
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57624889
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49445606
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47109437
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43907661
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42162228
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.39779805
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38150777
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35591100
45SMAD4_21799915_ChIP-Seq_A2780_Human1.35296782
46IGF1R_20145208_ChIP-Seq_DFB_Human1.31133581
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31058346
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28119852
49P300_19829295_ChIP-Seq_ESCs_Human1.27717653
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.24693397
51CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.23153367
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19800708
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15475938
54SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14650221
55RNF2_27304074_Chip-Seq_NSC_Mouse1.12618590
56SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08724716
57OCT4_19829295_ChIP-Seq_ESCs_Human1.08722189
58CTCF_27219007_Chip-Seq_Bcells_Human1.07614392
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07469197
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.06844778
61AR_25329375_ChIP-Seq_VCAP_Human1.06817929
62TET1_21490601_ChIP-Seq_MESCs_Mouse1.03738100
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03332204
64GATA1_26923725_Chip-Seq_HPCs_Mouse1.02894744
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01200150
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.00483993
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00063893
68JUN_21703547_ChIP-Seq_K562_Human0.98244792
69* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97426715
70P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97177614
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96813464
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96674713
73AR_19668381_ChIP-Seq_PC3_Human0.96391238
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95842586
75SMAD3_21741376_ChIP-Seq_EPCs_Human0.95394039
76RING1B_27294783_Chip-Seq_NPCs_Mouse0.94648289
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93474023
78SMC4_20622854_ChIP-Seq_HELA_Human0.93148552
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93084485
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92903837
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92009180
82KDM2B_26808549_Chip-Seq_K562_Human0.91220582
83PIAS1_25552417_ChIP-Seq_VCAP_Human0.90770243
84STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90294320
85* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88965250
86SMAD3_21741376_ChIP-Seq_ESCs_Human0.88662647
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88618241
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88465223
89VDR_22108803_ChIP-Seq_LS180_Human0.87603961
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87146654
91TP53_20018659_ChIP-ChIP_R1E_Mouse0.86952299
92P68_20966046_ChIP-Seq_HELA_Human0.86575079
93STAT3_23295773_ChIP-Seq_U87_Human0.86325031
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.84922476
95DPY_21335234_ChIP-Seq_ESCs_Mouse0.84259161
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84178233
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83900636
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83564344
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82756058
100KLF4_19829295_ChIP-Seq_ESCs_Human0.82215685
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81907967
102REST_19997604_ChIP-ChIP_NEURONS_Mouse0.81744923
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81156054
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81156054
105RUNX2_22187159_ChIP-Seq_PCA_Human0.81066382
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79869723
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79857009
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79352079
109LXR_22292898_ChIP-Seq_THP-1_Human0.79300824
110POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77904721
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.77309837
112SMAD4_21741376_ChIP-Seq_ESCs_Human0.77171796
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77063679
114WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76851905
115ZNF263_19887448_ChIP-Seq_K562_Human0.76758278
116EGR1_19032775_ChIP-ChIP_M12_Human0.75243909
117AHR_22903824_ChIP-Seq_MCF-7_Human0.75073197
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74664090
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.74503548
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.74308185
121TCF4_23295773_ChIP-Seq_U87_Human0.74061067
122MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.73940975
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.71162519
124TET1_21451524_ChIP-Seq_MESCs_Mouse0.70046765
125CTCF_20526341_ChIP-Seq_ESCs_Human0.69098879
126NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.67972846
127* SA1_27219007_Chip-Seq_Bcells_Human0.67608112
128RUNX1_26923725_Chip-Seq_HPCs_Mouse0.67256780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.83593608
2MP0003880_abnormal_central_pattern4.28305457
3MP0004270_analgesia3.67418416
4MP0003635_abnormal_synaptic_transmissio3.55024475
5MP0006276_abnormal_autonomic_nervous3.42357002
6MP0001968_abnormal_touch/_nociception3.09385145
7MP0009745_abnormal_behavioral_response2.87841576
8MP0002734_abnormal_mechanical_nocicepti2.85159554
9MP0002063_abnormal_learning/memory/cond2.76024167
10MP0002064_seizures2.67666606
11MP0002735_abnormal_chemical_nociception2.64959676
12MP0005083_abnormal_biliary_tract2.63554117
13MP0005423_abnormal_somatic_nervous2.56211857
14MP0009046_muscle_twitch2.55090612
15MP0002736_abnormal_nociception_after2.51320356
16MP0002572_abnormal_emotion/affect_behav2.36864372
17MP0002272_abnormal_nervous_system2.36165892
18MP0002733_abnormal_thermal_nociception2.33287604
19MP0003122_maternal_imprinting2.31938381
20MP0001440_abnormal_grooming_behavior2.28408934
21MP0001970_abnormal_pain_threshold2.20654770
22MP0002184_abnormal_innervation2.18610646
23MP0001501_abnormal_sleep_pattern2.09628876
24MP0000778_abnormal_nervous_system1.96761560
25MP0004858_abnormal_nervous_system1.94625440
26MP0001486_abnormal_startle_reflex1.93489987
27MP0005645_abnormal_hypothalamus_physiol1.91901783
28MP0002067_abnormal_sensory_capabilities1.90588356
29MP0004924_abnormal_behavior1.86744731
30MP0005386_behavior/neurological_phenoty1.86744731
31MP0001666_abnormal_nutrient_absorption1.78000783
32MP0001529_abnormal_vocalization1.77229969
33MP0003329_amyloid_beta_deposits1.75186847
34MP0002557_abnormal_social/conspecific_i1.74793308
35MP0001984_abnormal_olfaction1.73403493
36MP0000955_abnormal_spinal_cord1.71365800
37MP0002822_catalepsy1.71157027
38MP0004811_abnormal_neuron_physiology1.70001101
39MP0004142_abnormal_muscle_tone1.62976955
40MP0005394_taste/olfaction_phenotype1.61216374
41MP0005499_abnormal_olfactory_system1.61216374
42MP0001905_abnormal_dopamine_level1.53488676
43MP0005084_abnormal_gallbladder_morpholo1.53294919
44MP0003123_paternal_imprinting1.46477651
45MP0001664_abnormal_digestion1.44905109
46MP0002882_abnormal_neuron_morphology1.43397180
47MP0003868_abnormal_feces_composition1.36333659
48MP0003879_abnormal_hair_cell1.36195659
49MP0002066_abnormal_motor_capabilities/c1.32761958
50MP0000920_abnormal_myelination1.28300873
51MP0002909_abnormal_adrenal_gland1.27487719
52MP0009780_abnormal_chondrocyte_physiolo1.27141093
53MP0008789_abnormal_olfactory_epithelium1.26350126
54MP0003690_abnormal_glial_cell1.19534314
55MP0005220_abnormal_exocrine_pancreas1.19066353
56MP0008569_lethality_at_weaning1.17596916
57MP0001188_hyperpigmentation1.15884152
58MP0001177_atelectasis1.15786582
59MP0008872_abnormal_physiological_respon1.14507667
60MP0008877_abnormal_DNA_methylation1.12790302
61MP0003787_abnormal_imprinting1.10732647
62MP0001502_abnormal_circadian_rhythm1.08252583
63MP0005167_abnormal_blood-brain_barrier1.07171654
64MP0005646_abnormal_pituitary_gland1.06542564
65MP0002152_abnormal_brain_morphology1.06114265
66MP0005535_abnormal_body_temperature1.03550062
67MP0010386_abnormal_urinary_bladder1.00425933
68MP0002229_neurodegeneration0.99239245
69MP0002752_abnormal_somatic_nervous0.99045759
70MP0004147_increased_porphyrin_level0.97571401
71MP0000751_myopathy0.97540008
72MP0004233_abnormal_muscle_weight0.94136819
73MP0003121_genomic_imprinting0.90028253
74MP0002069_abnormal_eating/drinking_beha0.89777012
75MP0004145_abnormal_muscle_electrophysio0.89263907
76MP0002751_abnormal_autonomic_nervous0.88739503
77MP0002638_abnormal_pupillary_reflex0.88085969
78MP0009379_abnormal_foot_pigmentation0.87827718
79MP0004742_abnormal_vestibular_system0.85448501
80MP0003633_abnormal_nervous_system0.84475689
81MP0005448_abnormal_energy_balance0.82034543
82MP0003959_abnormal_lean_body0.81855687
83MP0002876_abnormal_thyroid_physiology0.78217981
84MP0001346_abnormal_lacrimal_gland0.77813818
85MP0002693_abnormal_pancreas_physiology0.77721603
86MP0002837_dystrophic_cardiac_calcinosis0.77109841
87MP0003632_abnormal_nervous_system0.76964985
88MP0001963_abnormal_hearing_physiology0.76142726
89MP0003631_nervous_system_phenotype0.75861397
90MP0008874_decreased_physiological_sensi0.75573598
91MP0000631_abnormal_neuroendocrine_gland0.75234221
92MP0000604_amyloidosis0.74490668
93MP0005623_abnormal_meninges_morphology0.73998981
94MP0004885_abnormal_endolymph0.72998008
95MP0003075_altered_response_to0.71761397
96MP0003634_abnormal_glial_cell0.71485492
97MP0004085_abnormal_heartbeat0.71262316
98MP0001348_abnormal_lacrimal_gland0.67990212
99MP0003861_abnormal_nervous_system0.66764740
100MP0004133_heterotaxia0.66175247
101MP0000026_abnormal_inner_ear0.65516532
102MP0000013_abnormal_adipose_tissue0.65293718
103MP0005551_abnormal_eye_electrophysiolog0.64826029
104MP0003137_abnormal_impulse_conducting0.64063909
105MP0006035_abnormal_mitochondrial_morpho0.63597642
106MP0000566_synostosis0.62784701
107MP0001485_abnormal_pinna_reflex0.61589091
108MP0002234_abnormal_pharynx_morphology0.60930884
109MP0001986_abnormal_taste_sensitivity0.60815824
110MP0006072_abnormal_retinal_apoptosis0.60692783
111MP0004130_abnormal_muscle_cell0.59681383
112MP0008004_abnormal_stomach_pH0.59434937
113MP0002160_abnormal_reproductive_system0.57769521
114MP0003283_abnormal_digestive_organ0.56590968
115MP0001943_abnormal_respiration0.56533675
116MP0003956_abnormal_body_size0.56294550
117MP0003938_abnormal_ear_development0.55471700
118MP0005187_abnormal_penis_morphology0.54688594
119MP0010769_abnormal_survival0.51007340
120MP0002090_abnormal_vision0.49930777
121MP0006292_abnormal_olfactory_placode0.49309525
122MP0010768_mortality/aging0.48278432
123MP0010770_preweaning_lethality0.47771923
124MP0002082_postnatal_lethality0.47771923

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.33809360
2Focal motor seizures (HP:0011153)5.77414704
3Visual hallucinations (HP:0002367)4.99421009
4Atonic seizures (HP:0010819)4.92614519
5Focal seizures (HP:0007359)4.83964071
6Diplopia (HP:0000651)4.28952937
7Abnormality of binocular vision (HP:0011514)4.28952937
8Febrile seizures (HP:0002373)3.95606296
9Absence seizures (HP:0002121)3.95561324
10Epileptic encephalopathy (HP:0200134)3.84071606
11Limb dystonia (HP:0002451)3.59055701
12Generalized tonic-clonic seizures (HP:0002069)3.58929113
13Cerebral hypomyelination (HP:0006808)3.54800175
14Annular pancreas (HP:0001734)3.51300625
15Dialeptic seizures (HP:0011146)3.48190547
16Progressive cerebellar ataxia (HP:0002073)3.40897239
17Supranuclear gaze palsy (HP:0000605)3.39367727
18Ankle clonus (HP:0011448)3.09462828
19Pheochromocytoma (HP:0002666)3.03008857
20Amblyopia (HP:0000646)2.97012973
21Intention tremor (HP:0002080)2.95053410
22Neurofibrillary tangles (HP:0002185)2.94848816
23Hemiplegia (HP:0002301)2.92578068
24Papilledema (HP:0001085)2.90153892
25Polyphagia (HP:0002591)2.89058338
26Acute necrotizing encephalopathy (HP:0006965)2.88671852
27Tetraplegia (HP:0002445)2.86581732
28Failure to thrive in infancy (HP:0001531)2.84806699
29Anxiety (HP:0000739)2.81534889
30Clonus (HP:0002169)2.80388465
31Mutism (HP:0002300)2.78609196
32Insidious onset (HP:0003587)2.78575491
33Termporal pattern (HP:0011008)2.78575491
34Hemiparesis (HP:0001269)2.78381243
35Neuroendocrine neoplasm (HP:0100634)2.76310208
36Action tremor (HP:0002345)2.73180085
37Delusions (HP:0000746)2.72627837
38Poor suck (HP:0002033)2.64843688
39Progressive macrocephaly (HP:0004481)2.58860937
40Ventricular fibrillation (HP:0001663)2.58242950
41Epileptiform EEG discharges (HP:0011182)2.57948010
42Abnormal mitochondria in muscle tissue (HP:0008316)2.57062969
43Abnormal eating behavior (HP:0100738)2.55924799
44Depression (HP:0000716)2.55441486
45EEG with generalized epileptiform discharges (HP:0011198)2.54435772
46Hypoventilation (HP:0002791)2.50011190
47Truncal ataxia (HP:0002078)2.47823288
48Progressive inability to walk (HP:0002505)2.46718837
49Hypothermia (HP:0002045)2.45431842
50Hypsarrhythmia (HP:0002521)2.44000834
51Broad-based gait (HP:0002136)2.40977832
52Fetal akinesia sequence (HP:0001989)2.40152624
53Retinal dysplasia (HP:0007973)2.39556866
54Obstructive sleep apnea (HP:0002870)2.38716825
55CNS hypomyelination (HP:0003429)2.37458799
56Agitation (HP:0000713)2.35591697
57Impaired vibration sensation in the lower limbs (HP:0002166)2.35584232
58Urinary bladder sphincter dysfunction (HP:0002839)2.34762175
59Urinary urgency (HP:0000012)2.33167620
60Hyperthyroidism (HP:0000836)2.30934259
61Impaired vibratory sensation (HP:0002495)2.29886093
62Neuronal loss in central nervous system (HP:0002529)2.27862317
63Acute encephalopathy (HP:0006846)2.27492108
64Gait imbalance (HP:0002141)2.24448340
65Choreoathetosis (HP:0001266)2.22516329
66Mitochondrial inheritance (HP:0001427)2.21731940
67Poor eye contact (HP:0000817)2.20874123
68Impaired smooth pursuit (HP:0007772)2.20504359
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.18434785
70Degeneration of the lateral corticospinal tracts (HP:0002314)2.18434785
71Spastic tetraparesis (HP:0001285)2.17709716
72Excessive salivation (HP:0003781)2.17316758
73Drooling (HP:0002307)2.17316758
74Type II lissencephaly (HP:0007260)2.15252153
75Ulnar claw (HP:0001178)2.14717476
76Abnormality of pain sensation (HP:0010832)2.14532719
77Impaired pain sensation (HP:0007328)2.14532719
78Morphological abnormality of the pyramidal tract (HP:0002062)2.14348124
79Hyperventilation (HP:0002883)2.13574940
80Bradykinesia (HP:0002067)2.12945486
81Cerebral inclusion bodies (HP:0100314)2.12806987
82Incomplete penetrance (HP:0003829)2.12797594
83Abnormality of the corticospinal tract (HP:0002492)2.10705579
84Split foot (HP:0001839)2.08706081
85Spastic gait (HP:0002064)2.08014189
86Apathy (HP:0000741)2.07894676
87Short chin (HP:0000331)2.06962811
88Peripheral hypomyelination (HP:0007182)2.06383850
89Abnormal ciliary motility (HP:0012262)2.05189750
90Abnormal respiratory motile cilium physiology (HP:0012261)2.04559712
91Hypercortisolism (HP:0001578)2.03303597
92Stereotypic behavior (HP:0000733)2.03194658
93Akinesia (HP:0002304)2.01292583
94Generalized hypotonia (HP:0001290)2.00816391
95Abnormal social behavior (HP:0012433)1.99952976
96Impaired social interactions (HP:0000735)1.99952976
97Neoplasm of the peripheral nervous system (HP:0100007)1.99729241
98Inability to walk (HP:0002540)1.99533683
99Dysmetria (HP:0001310)1.98359521
100Abnormality of ocular smooth pursuit (HP:0000617)1.98038968
101Megalencephaly (HP:0001355)1.97043905
102Torticollis (HP:0000473)1.96518519
103Postural instability (HP:0002172)1.95955770
104Abnormal hair whorl (HP:0010721)1.95518592
105Spinal canal stenosis (HP:0003416)1.95284925
106Hypoplasia of the brainstem (HP:0002365)1.95026064
107Aplasia/Hypoplasia of the brainstem (HP:0007362)1.95026064
108Abnormality of the lower motor neuron (HP:0002366)1.94811885
109Gaze-evoked nystagmus (HP:0000640)1.94457887
110Abnormality of the labia minora (HP:0012880)1.94448210
111Rigidity (HP:0002063)1.92219820
112Lower limb asymmetry (HP:0100559)1.91918983
113Psychosis (HP:0000709)1.90235346
114Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89098517
115Status epilepticus (HP:0002133)1.88564868
116Generalized myoclonic seizures (HP:0002123)1.88292035
117Athetosis (HP:0002305)1.87842801
118Diminished motivation (HP:0000745)1.87385030
119Focal dystonia (HP:0004373)1.84672357
120Emotional lability (HP:0000712)1.84219277
121Insomnia (HP:0100785)1.84139637
122Lissencephaly (HP:0001339)1.83460361
123Sleep apnea (HP:0010535)1.82826195
124Specific learning disability (HP:0001328)1.79378047
125Esotropia (HP:0000565)1.78550836
126Unsteady gait (HP:0002317)1.78341893
127Absent speech (HP:0001344)1.77394277
128Abnormal respiratory motile cilium morphology (HP:0005938)1.76830136
129Abnormal respiratory epithelium morphology (HP:0012253)1.76830136
130Craniofacial dystonia (HP:0012179)1.75894291
131Abnormal pupillary function (HP:0007686)1.75391241
132Lower limb muscle weakness (HP:0007340)1.75368857
133Dysdiadochokinesis (HP:0002075)1.75320031
134Amyotrophic lateral sclerosis (HP:0007354)1.75264296
135Increased CSF lactate (HP:0002490)1.74846113
136Spastic tetraplegia (HP:0002510)1.72342352
137Abnormal EKG (HP:0003115)1.71711236
138Prolonged QT interval (HP:0001657)1.70901750
139Increased circulating renin level (HP:0000848)1.68189279
140Iris hypopigmentation (HP:0007730)1.62486260
141Rapidly progressive (HP:0003678)1.62169976

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.97549539
2MARK13.84287838
3MAP3K93.62709043
4MINK13.36103125
5MAP3K43.26949482
6MAP3K123.14833073
7MAP2K72.72238538
8PNCK2.61911379
9DAPK22.37466590
10EPHA42.35901390
11NTRK12.29922576
12CASK2.23530458
13MAP2K42.15035461
14ARAF2.05420471
15GRK51.96294362
16MAPK131.85480646
17NME11.84531293
18KSR21.80897894
19PAK61.72564132
20NTRK21.65878861
21PLK21.59227650
22LATS21.54176831
23DAPK11.50458079
24PHKG11.40443875
25PHKG21.40443875
26CAMKK11.34998937
27CDK51.32850212
28PRKCG1.30156797
29CDK191.28832042
30KSR11.20443702
31PRKCH1.19032171
32CSNK1G21.15937372
33UHMK11.12286595
34MAP3K21.11482408
35PRKD31.10783384
36DYRK1A1.06588996
37RIPK41.06490897
38CDK141.05313675
39CAMK2A1.05111277
40BCKDK1.03243120
41NEK61.00427010
42CAMKK20.98199743
43SIK20.97108549
44MAP2K10.95969051
45SCYL20.94822808
46MAPKAPK30.92057511
47CDK180.91795893
48CDK150.90555880
49ALK0.90415582
50CSNK1G30.89302086
51BRSK10.88259998
52RET0.88053798
53CAMK2B0.86757704
54PAK30.85777470
55LMTK20.83716285
56CDK11A0.81689013
57PKN10.81049669
58WNK40.79521690
59GRK70.79196114
60LIMK10.77027359
61DYRK20.76057058
62CAMK40.75834686
63BRAF0.74489209
64FER0.74114743
65STK380.73305990
66MAP2K20.71883302
67TAOK10.69519159
68CAMK2G0.69493911
69PRKCZ0.67420093
70FES0.65672537
71PDK10.65414585
72MAP2K60.64417994
73RPS6KA20.63349622
74DAPK30.62005963
75STK390.61817873
76SGK20.61390797
77TNK20.61305270
78CCNB10.60158383
79BMPR20.59761365
80STK110.59554619
81CAMK2D0.58397463
82SGK10.55780346
83PRKCI0.55214334
84ADRBK10.53586412
85STK160.52574940
86PTK2B0.52060742
87PRKCE0.50763994
88RAF10.50340878
89RPS6KA30.50278595
90PRPF4B0.50187335
91MAPK100.48530269
92MAPKAPK50.48280331
93RIPK10.47265571
94SGK4940.45780916
95SGK2230.45780916
96PRKCA0.45258814
97CSNK1E0.44344807
98MAP4K20.43820803
99SGK30.43301802
100CSNK1G10.43161408
101FGFR20.42329690
102MAP3K110.41835352
103OXSR10.41512156
104TYRO30.41434501
105MAP3K10.40919442
106CAMK10.39567662
107PINK10.39488318
108PDPK10.39222976
109AURKA0.38891904
110ERBB30.36833095
111CSNK1A1L0.36241602
112FGR0.35181575
113TSSK60.34983248
114PRKG20.34896518
115MAPK120.34722149
116MARK20.34151885
117MAP3K60.33460389
118TNIK0.32878396
119ERBB20.32503850
120FYN0.32355853
121NEK10.32290814
122PRKACA0.31895017
123CSNK1A10.29798495
124WNK30.27463394
125ROCK10.27299614
126CSNK1D0.26689650
127FRK0.26242100
128PRKG10.26227388

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.69031343
2Nicotine addiction_Homo sapiens_hsa050333.22048491
3Pancreatic secretion_Homo sapiens_hsa049723.19132147
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.56185039
5Oxidative phosphorylation_Homo sapiens_hsa001902.53660450
6Olfactory transduction_Homo sapiens_hsa047402.47832319
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35030634
8GABAergic synapse_Homo sapiens_hsa047272.32811528
9Parkinsons disease_Homo sapiens_hsa050122.32542742
10Collecting duct acid secretion_Homo sapiens_hsa049662.26289260
11Amphetamine addiction_Homo sapiens_hsa050312.21074758
12Long-term potentiation_Homo sapiens_hsa047202.20492159
13Dopaminergic synapse_Homo sapiens_hsa047282.16679831
14Circadian entrainment_Homo sapiens_hsa047132.12072960
15Insulin secretion_Homo sapiens_hsa049112.07308328
16Morphine addiction_Homo sapiens_hsa050321.99967855
17* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.96022862
18Glutamatergic synapse_Homo sapiens_hsa047241.95564531
19Vitamin B6 metabolism_Homo sapiens_hsa007501.94248682
20Alzheimers disease_Homo sapiens_hsa050101.91931043
21Cholinergic synapse_Homo sapiens_hsa047251.87291464
22Taste transduction_Homo sapiens_hsa047421.84859100
23Vibrio cholerae infection_Homo sapiens_hsa051101.75552732
24Salivary secretion_Homo sapiens_hsa049701.74328086
25Serotonergic synapse_Homo sapiens_hsa047261.69931529
26Gastric acid secretion_Homo sapiens_hsa049711.67195839
27Huntingtons disease_Homo sapiens_hsa050161.62993204
28Cocaine addiction_Homo sapiens_hsa050301.62309460
29Cardiac muscle contraction_Homo sapiens_hsa042601.60270857
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42945453
31Renin secretion_Homo sapiens_hsa049241.39705000
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38559333
33Long-term depression_Homo sapiens_hsa047301.38468144
34Calcium signaling pathway_Homo sapiens_hsa040201.32137498
35Protein digestion and absorption_Homo sapiens_hsa049741.30664138
36Gap junction_Homo sapiens_hsa045401.30513116
37GnRH signaling pathway_Homo sapiens_hsa049121.29945128
38Fat digestion and absorption_Homo sapiens_hsa049751.26528631
39Oxytocin signaling pathway_Homo sapiens_hsa049211.23710259
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19128337
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16255198
42Estrogen signaling pathway_Homo sapiens_hsa049151.10328338
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10186705
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01010587
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00372985
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98000634
47Oocyte meiosis_Homo sapiens_hsa041140.96649449
48Melanogenesis_Homo sapiens_hsa049160.94485321
49Axon guidance_Homo sapiens_hsa043600.87604132
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84326516
51Phototransduction_Homo sapiens_hsa047440.82546672
52cAMP signaling pathway_Homo sapiens_hsa040240.82295265
53Glioma_Homo sapiens_hsa052140.80153173
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79776714
55Glycerolipid metabolism_Homo sapiens_hsa005610.74820850
56ErbB signaling pathway_Homo sapiens_hsa040120.74646583
57Bile secretion_Homo sapiens_hsa049760.74416243
58Protein export_Homo sapiens_hsa030600.72815082
59Thyroid hormone synthesis_Homo sapiens_hsa049180.71611191
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71360235
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.69122879
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69088278
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67772575
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65549938
65Arginine and proline metabolism_Homo sapiens_hsa003300.65350380
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64035881
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58943045
68Alcoholism_Homo sapiens_hsa050340.57935011
69Type II diabetes mellitus_Homo sapiens_hsa049300.57200066
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55604152
71VEGF signaling pathway_Homo sapiens_hsa043700.53266739
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52346148
73Nitrogen metabolism_Homo sapiens_hsa009100.51745770
74Dorso-ventral axis formation_Homo sapiens_hsa043200.50673458
75Arginine biosynthesis_Homo sapiens_hsa002200.50299544
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50227842
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49042378
78Glucagon signaling pathway_Homo sapiens_hsa049220.47265179
79Insulin signaling pathway_Homo sapiens_hsa049100.46850361
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46751985
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45909966
82Prion diseases_Homo sapiens_hsa050200.44462469
83Mineral absorption_Homo sapiens_hsa049780.44251921
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43432966
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42997034
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.42550957
87MAPK signaling pathway_Homo sapiens_hsa040100.41608350
88Choline metabolism in cancer_Homo sapiens_hsa052310.41270900
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.41165636
90Endometrial cancer_Homo sapiens_hsa052130.41042528
91Regulation of autophagy_Homo sapiens_hsa041400.40210970
92Ras signaling pathway_Homo sapiens_hsa040140.38876867
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36867797
94* Neurotrophin signaling pathway_Homo sapiens_hsa047220.36842467
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.35431482
96beta-Alanine metabolism_Homo sapiens_hsa004100.35013227
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31570648
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.30715999
99Histidine metabolism_Homo sapiens_hsa003400.29991765
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29776618
101Ovarian steroidogenesis_Homo sapiens_hsa049130.29154817
102Dilated cardiomyopathy_Homo sapiens_hsa054140.28708376
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28111517
104Renal cell carcinoma_Homo sapiens_hsa052110.26436314
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26069945
106Butanoate metabolism_Homo sapiens_hsa006500.25451305
107Wnt signaling pathway_Homo sapiens_hsa043100.24910799
108Endocytosis_Homo sapiens_hsa041440.24229411
109Fatty acid biosynthesis_Homo sapiens_hsa000610.23735637
110Type I diabetes mellitus_Homo sapiens_hsa049400.22295692
111Inositol phosphate metabolism_Homo sapiens_hsa005620.21830380
112Ether lipid metabolism_Homo sapiens_hsa005650.21745196
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21520217
114Rap1 signaling pathway_Homo sapiens_hsa040150.21207048
115Colorectal cancer_Homo sapiens_hsa052100.20843371
116mTOR signaling pathway_Homo sapiens_hsa041500.20008424
117Circadian rhythm_Homo sapiens_hsa047100.18830184

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