ARHGAP9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.07530759
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.71267214
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.71267214
4negative regulation of cell killing (GO:0031342)5.40122212
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.40122212
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.36123909
7leukocyte aggregation (GO:0070486)5.24420340
8antigen processing and presentation of endogenous antigen (GO:0019883)5.14506233
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.04497638
10regulation of B cell receptor signaling pathway (GO:0050855)4.86744070
11detection of other organism (GO:0098543)4.85463812
12detection of bacterium (GO:0016045)4.77159303
13regulation of gamma-delta T cell differentiation (GO:0045586)4.76468866
14negative T cell selection (GO:0043383)4.64002015
15negative thymic T cell selection (GO:0045060)4.58488165
16positive thymic T cell selection (GO:0045059)4.54122684
17regulation of gamma-delta T cell activation (GO:0046643)4.41222203
18negative regulation of lymphocyte mediated immunity (GO:0002707)4.39001062
19response to interleukin-15 (GO:0070672)4.36455966
20macrophage activation involved in immune response (GO:0002281)4.31033611
21response to peptidoglycan (GO:0032494)4.22677198
22T cell migration (GO:0072678)4.13508394
23interferon-gamma production (GO:0032609)4.08597941
24cellular response to interleukin-15 (GO:0071350)4.07168464
25detection of external biotic stimulus (GO:0098581)4.02446003
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.97437445
27thymic T cell selection (GO:0045061)3.93831599
28negative regulation of leukocyte mediated immunity (GO:0002704)3.92615308
29regulation of B cell differentiation (GO:0045577)3.86351580
30positive T cell selection (GO:0043368)3.83563159
31negative regulation of T cell mediated immunity (GO:0002710)3.82616465
32regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.72314583
33antigen processing and presentation via MHC class Ib (GO:0002475)3.69587425
34negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.67592735
35immunoglobulin mediated immune response (GO:0016064)3.64930029
36T cell selection (GO:0045058)3.63746682
37regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.62337721
38positive regulation of B cell differentiation (GO:0045579)3.59180281
39leukocyte migration involved in inflammatory response (GO:0002523)3.58196288
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.56127217
41response to host immune response (GO:0052572)3.56127217
42myeloid cell activation involved in immune response (GO:0002275)3.55903184
43detection of molecule of bacterial origin (GO:0032490)3.55057904
44ribosomal small subunit assembly (GO:0000028)3.54739368
45detection of biotic stimulus (GO:0009595)3.52149477
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.51250736
47B cell receptor signaling pathway (GO:0050853)3.50880681
48regulation of mast cell degranulation (GO:0043304)3.50714138
49mast cell activation (GO:0045576)3.50397955
50microglial cell activation (GO:0001774)3.46791226
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.45699632
52regulation of tolerance induction (GO:0002643)3.42061713
53neutrophil mediated immunity (GO:0002446)3.40948334
54negative regulation of phagocytosis (GO:0050765)3.39054648
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.36244022
56regulation of T cell receptor signaling pathway (GO:0050856)3.35924459
57response to muramyl dipeptide (GO:0032495)3.35696196
58neutrophil activation involved in immune response (GO:0002283)3.35494176
59T cell receptor signaling pathway (GO:0050852)3.35357272
60antigen receptor-mediated signaling pathway (GO:0050851)3.34741495
61cellular extravasation (GO:0045123)3.32597186
62leukocyte degranulation (GO:0043299)3.30864986
63regulation of isotype switching to IgG isotypes (GO:0048302)3.30590111
64response to type I interferon (GO:0034340)3.29984106
65regulation of dendritic cell antigen processing and presentation (GO:0002604)3.29898371
66respiratory burst (GO:0045730)3.29548755
67regulation of T cell mediated cytotoxicity (GO:0001914)3.27294712
68response to host (GO:0075136)3.26707940
69response to host defenses (GO:0052200)3.26707940
70response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.26707940
71type I interferon signaling pathway (GO:0060337)3.26281296
72cellular response to type I interferon (GO:0071357)3.26281296
73regulation of myeloid leukocyte mediated immunity (GO:0002886)3.23673436
74germinal center formation (GO:0002467)3.22940308
75regulation of alpha-beta T cell proliferation (GO:0046640)3.22926696
76regulation of mast cell activation involved in immune response (GO:0033006)3.22509076
77regulation of interleukin-12 biosynthetic process (GO:0045075)3.22125592
78tolerance induction (GO:0002507)3.21947578
79negative regulation of erythrocyte differentiation (GO:0045647)3.20855844
80positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.20531693
81positive regulation of T cell mediated cytotoxicity (GO:0001916)3.19469940
82macrophage activation (GO:0042116)3.19095580
83leukocyte cell-cell adhesion (GO:0007159)3.19057575
84regulation of response to interferon-gamma (GO:0060330)3.18761192
85T cell homeostasis (GO:0043029)3.18418951
86production of molecular mediator involved in inflammatory response (GO:0002532)3.18349735
87positive regulation of mast cell activation (GO:0033005)3.17455694
88regulation of type I interferon-mediated signaling pathway (GO:0060338)3.17188851
89cellular response to interferon-beta (GO:0035458)3.15592534
90negative regulation of innate immune response (GO:0045824)3.13371805
91negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.13246348
92negative regulation of T-helper cell differentiation (GO:0045623)3.13246348
93regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.12699908
94regulation of T cell tolerance induction (GO:0002664)3.10689317
95T cell costimulation (GO:0031295)3.10427208
96regulation of mast cell activation (GO:0033003)3.10034615
97regulation of regulatory T cell differentiation (GO:0045589)3.08610466
98B cell mediated immunity (GO:0019724)3.08095939
99regulation of leukocyte degranulation (GO:0043300)3.07705723
100lymphocyte costimulation (GO:0031294)3.06282330
101regulation of antigen processing and presentation (GO:0002577)3.05765073
102positive regulation of isotype switching (GO:0045830)3.05379351
103interferon-gamma-mediated signaling pathway (GO:0060333)3.03877787
104positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03760843
105response to protozoan (GO:0001562)2.99390167
106positive regulation of antigen processing and presentation (GO:0002579)2.99261750
107defense response to protozoan (GO:0042832)2.99230358
108regulation of natural killer cell mediated immunity (GO:0002715)2.98825685
109regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98825685
110NIK/NF-kappaB signaling (GO:0038061)2.98758663
111neutrophil activation (GO:0042119)2.97142195
112negative regulation of interleukin-6 production (GO:0032715)2.96737788
113dendritic cell chemotaxis (GO:0002407)2.95570005
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.94812998
115cellular response to zinc ion (GO:0071294)2.92705755
116viral transcription (GO:0019083)2.92488701
117positive regulation of interleukin-2 production (GO:0032743)2.92339738
118myeloid dendritic cell activation (GO:0001773)2.92231292
119sequestering of actin monomers (GO:0042989)2.88336849
120positive regulation of lamellipodium assembly (GO:0010592)2.87991341
121actin nucleation (GO:0045010)2.87880097
122modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.85199832
123positive regulation by organism of defense response of other organism involved in symbiotic interact2.85199832
124modulation by symbiont of host immune response (GO:0052553)2.85199832
125positive regulation by symbiont of host defense response (GO:0052509)2.85199832
126modulation by symbiont of host defense response (GO:0052031)2.85199832
127modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.85199832
128negative regulation of interleukin-12 production (GO:0032695)2.85100843
129response to interferon-beta (GO:0035456)2.83440488
130lymphocyte homeostasis (GO:0002260)2.83229269
131negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.82763204
132regulation of interferon-beta biosynthetic process (GO:0045357)2.82372898
133regulation of interleukin-2 biosynthetic process (GO:0045076)2.80313355
134natural killer cell activation (GO:0030101)2.79381254
135positive regulation of interferon-alpha production (GO:0032727)2.76151368
136translational termination (GO:0006415)2.75751522
137mast cell degranulation (GO:0043303)2.75489019
138mast cell activation involved in immune response (GO:0002279)2.75489019
139granulocyte activation (GO:0036230)2.74053449
140positive regulation of B cell mediated immunity (GO:0002714)2.72203629
141positive regulation of immunoglobulin mediated immune response (GO:0002891)2.72203629
142positive regulation of granulocyte differentiation (GO:0030854)2.70935097
143positive regulation of tolerance induction (GO:0002645)2.70659746
144activated T cell proliferation (GO:0050798)2.69876512
145positive regulation of natural killer cell mediated immunity (GO:0002717)2.68788833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.46059712
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.39803181
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.22402128
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.88028385
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.52790816
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.45307741
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.42997466
8MYC_22102868_ChIP-Seq_BL_Human2.97154056
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.90469810
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.71460427
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.69133582
12VDR_21846776_ChIP-Seq_THP-1_Human2.66111087
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66088953
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63747176
15* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.57750822
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.55430857
17MYB_26560356_Chip-Seq_TH2_Human2.55408117
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54582891
19* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52250944
20* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45429109
21SCL_19346495_ChIP-Seq_HPC-7_Human2.43858097
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.42750334
23* MAF_26560356_Chip-Seq_TH1_Human2.38645285
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.38498752
25* SPI1_23547873_ChIP-Seq_NB4_Human2.36132050
26* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33983923
27RUNX_20019798_ChIP-Seq_JUKART_Human2.23863572
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22446677
29* MYB_26560356_Chip-Seq_TH1_Human2.17716970
30UTX_26944678_Chip-Seq_JUKART_Human2.16925867
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.16912579
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16189812
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.09147650
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.06254313
35BRD4_27068464_Chip-Seq_AML-cells_Mouse2.00221059
36VDR_24763502_ChIP-Seq_THP-1_Human1.99531965
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95524233
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91400964
39* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78076047
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76941229
41TCF7_22412390_ChIP-Seq_EML_Mouse1.73314202
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73019675
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.72519914
44MAF_26560356_Chip-Seq_TH2_Human1.68096152
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67095497
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.60006667
47VDR_24787735_ChIP-Seq_THP-1_Human1.58651337
48SPI1_23127762_ChIP-Seq_K562_Human1.51289042
49GATA3_27048872_Chip-Seq_THYMUS_Human1.50930410
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46627061
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46230309
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46036715
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41181611
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39440100
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.39265621
56CIITA_25753668_ChIP-Seq_RAJI_Human1.39218576
57* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.39088553
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38626614
59VDR_23849224_ChIP-Seq_CD4+_Human1.38372105
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37958078
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36576027
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34313950
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33454442
64* PU_27001747_Chip-Seq_BMDM_Mouse1.32109063
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27533814
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27014501
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27006934
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24147544
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22381168
70MYC_18555785_ChIP-Seq_MESCs_Mouse1.22145917
71FOXP3_21729870_ChIP-Seq_TREG_Human1.21739279
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20638936
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20599253
74KDM2B_26808549_Chip-Seq_DND41_Human1.20452065
75BCL6_27268052_Chip-Seq_Bcells_Human1.20089268
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18829411
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.17341632
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.15813843
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15643128
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15627216
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15307741
82GATA1_22025678_ChIP-Seq_K562_Human1.13873823
83GATA1_19941826_ChIP-Seq_K562_Human1.13866772
84* LXR_22292898_ChIP-Seq_THP-1_Human1.13537235
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12413227
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09968176
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09819690
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08873318
89GATA3_26560356_Chip-Seq_TH2_Human1.08594740
90BCOR_27268052_Chip-Seq_Bcells_Human1.07638344
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07635725
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04870088
93* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04242100
94* GABP_17652178_ChIP-ChIP_JURKAT_Human1.03567699
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03393073
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03325675
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00544625
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00053023
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99977959
100* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99770075
101KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99098006
102GATA1_19941827_ChIP-Seq_MEL_Mouse0.98497615
103* EST1_17652178_ChIP-ChIP_JURKAT_Human0.97937406
104* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96021130
105MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95349067
106XRN2_22483619_ChIP-Seq_HELA_Human0.94692457
107TFEB_21752829_ChIP-Seq_HELA_Human0.94109279
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93137814
109GATA2_21666600_ChIP-Seq_HMVEC_Human0.91302771
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89609163
111SPI1_20517297_ChIP-Seq_HL60_Human0.89155985
112ELF1_20517297_ChIP-Seq_JURKAT_Human0.89155486
113NCOR1_26117541_ChIP-Seq_K562_Human0.87806203
114* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87559568
115RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87051595
116GATA2_19941826_ChIP-Seq_K562_Human0.86593537
117* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86310228
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86114137
119MYC_19079543_ChIP-ChIP_MESCs_Mouse0.85928791
120ETS1_20019798_ChIP-Seq_JURKAT_Human0.85538514
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85480201
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85178557
123ELK1_19687146_ChIP-ChIP_HELA_Human0.83375796
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82576367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.01552119
2MP0005671_abnormal_response_to3.57245546
3MP0003763_abnormal_thymus_physiology3.47216907
4MP0000685_abnormal_immune_system3.35865033
5MP0009785_altered_susceptibility_to3.15481863
6MP0003436_decreased_susceptibility_to3.08739595
7MP0001800_abnormal_humoral_immune3.05805668
8MP0005000_abnormal_immune_tolerance2.87967439
9MP0005387_immune_system_phenotype2.81939170
10MP0001790_abnormal_immune_system2.81939170
11MP0005025_abnormal_response_to2.76486717
12MP0002452_abnormal_antigen_presenting2.75307164
13MP0002420_abnormal_adaptive_immunity2.75004983
14MP0002723_abnormal_immune_serum2.73597847
15MP0001819_abnormal_immune_cell2.72402578
16MP0002396_abnormal_hematopoietic_system2.68392990
17MP0002398_abnormal_bone_marrow2.58499670
18MP0002419_abnormal_innate_immunity2.58264413
19MP0002166_altered_tumor_susceptibility2.51553358
20MP0003303_peritoneal_inflammation2.48054269
21MP0002148_abnormal_hypersensitivity_rea2.38681388
22MP0002405_respiratory_system_inflammati2.36177301
23MP0003724_increased_susceptibility_to2.33773540
24MP0000716_abnormal_immune_system2.31655594
25MP0009333_abnormal_splenocyte_physiolog2.26614316
26MP0006082_CNS_inflammation2.24581755
27MP0005464_abnormal_platelet_physiology2.24156524
28MP0000689_abnormal_spleen_morphology2.17876815
29MP0002006_tumorigenesis2.14358663
30MP0002722_abnormal_immune_system2.13496967
31MP0001873_stomach_inflammation2.02328398
32MP0010155_abnormal_intestine_physiology1.98926808
33MP0002429_abnormal_blood_cell1.97362046
34MP0001853_heart_inflammation1.94327448
35MP0000703_abnormal_thymus_morphology1.93754230
36MP0004808_abnormal_hematopoietic_stem1.87141414
37MP0004947_skin_inflammation1.84915665
38MP0005397_hematopoietic_system_phenotyp1.84907823
39MP0001545_abnormal_hematopoietic_system1.84907823
40MP0001845_abnormal_inflammatory_respons1.83305993
41MP0009278_abnormal_bone_marrow1.81637214
42MP0003300_gastrointestinal_ulcer1.77768175
43MP0008260_abnormal_autophagy1.71065828
44MP0003866_abnormal_defecation1.65388494
45MP0000465_gastrointestinal_hemorrhage1.61523894
46MP0004510_myositis1.58394991
47MP0005174_abnormal_tail_pigmentation1.56991229
48MP0000858_altered_metastatic_potential1.55841413
49MP0000490_abnormal_crypts_of1.46938246
50MP0002933_joint_inflammation1.44938073
51MP0001533_abnormal_skeleton_physiology1.44863788
52MP0005058_abnormal_lysosome_morphology1.42004233
53MP0008469_abnormal_protein_level1.39987844
54MP0005075_abnormal_melanosome_morpholog1.37316143
55MP0003172_abnormal_lysosome_physiology1.32612493
56MP0005310_abnormal_salivary_gland1.31361477
57MP0003448_altered_tumor_morphology1.30437476
58MP0002277_abnormal_respiratory_mucosa1.28515684
59MP0005451_abnormal_body_composition1.25163013
60MP0003191_abnormal_cellular_cholesterol1.24484886
61MP0003693_abnormal_embryo_hatching1.20873205
62MP0002019_abnormal_tumor_incidence1.14805385
63MP0004883_abnormal_blood_vessel1.13836446
64MP0001851_eye_inflammation1.07149860
65MP0000343_altered_response_to1.04140805
66MP0009764_decreased_sensitivity_to1.00347900
67MP0003077_abnormal_cell_cycle0.98879331
68MP0001986_abnormal_taste_sensitivity0.94700773
69MP0009840_abnormal_foam_cell0.94602460
70MP0010094_abnormal_chromosome_stability0.91132461
71MP0000015_abnormal_ear_pigmentation0.89775033
72MP0008057_abnormal_DNA_replication0.88985632
73MP0004381_abnormal_hair_follicle0.86100576
74MP0002998_abnormal_bone_remodeling0.84878680
75MP0005164_abnormal_response_to0.84526322
76MP0003690_abnormal_glial_cell0.83759446
77MP0010352_gastrointestinal_tract_polyps0.83684549
78MP0002138_abnormal_hepatobiliary_system0.83580467
79MP0002132_abnormal_respiratory_system0.83224338
80MP0009763_increased_sensitivity_to0.82403941
81MP0002095_abnormal_skin_pigmentation0.81488453
82MP0010307_abnormal_tumor_latency0.80853979
83MP0005023_abnormal_wound_healing0.77914820
84MP0003045_fibrosis0.76102035
85MP0003183_abnormal_peptide_metabolism0.74578792
86MP0004957_abnormal_blastocyst_morpholog0.73578356
87MP0005166_decreased_susceptibility_to0.72036349
88MP0003828_pulmonary_edema0.71739146
89MP0000371_diluted_coat_color0.71185550
90MP0003111_abnormal_nucleus_morphology0.69890771
91MP0003806_abnormal_nucleotide_metabolis0.68373888
92MP0000313_abnormal_cell_death0.68221007
93MP0001663_abnormal_digestive_system0.67861147
94MP0008007_abnormal_cellular_replicative0.67455225
95MP0008058_abnormal_DNA_repair0.67369239
96MP0008004_abnormal_stomach_pH0.66920678
97MP0002928_abnormal_bile_duct0.64996347
98MP0003656_abnormal_erythrocyte_physiolo0.64493186
99MP0000604_amyloidosis0.63022551
100MP0003252_abnormal_bile_duct0.60850241
101MP0005076_abnormal_cell_differentiation0.58886962
102MP0005377_hearing/vestibular/ear_phenot0.58619938
103MP0003878_abnormal_ear_physiology0.58619938
104MP0008874_decreased_physiological_sensi0.56317403
105MP0003795_abnormal_bone_structure0.56224530
106MP0004130_abnormal_muscle_cell0.56147692
107MP0009765_abnormal_xenobiotic_induced0.55499979
108MP0003566_abnormal_cell_adhesion0.54472355
109MP0000477_abnormal_intestine_morphology0.54249746
110MP0000249_abnormal_blood_vessel0.53391058
111MP0003075_altered_response_to0.53136003
112MP0005390_skeleton_phenotype0.52546799
113MP0000609_abnormal_liver_physiology0.51592770
114MP0005319_abnormal_enzyme/_coenzyme0.51022609
115MP0008873_increased_physiological_sensi0.50833272
116MP0002136_abnormal_kidney_physiology0.50072659
117MP0002693_abnormal_pancreas_physiology0.49589399
118MP0000598_abnormal_liver_morphology0.48134550
119MP0003453_abnormal_keratinocyte_physiol0.48050634
120MP0002009_preneoplasia0.44801917
121MP0005381_digestive/alimentary_phenotyp0.43560578
122MP0005388_respiratory_system_phenotype0.41819446
123MP0002133_abnormal_respiratory_system0.41819446

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.44519216
2Recurrent abscess formation (HP:0002722)5.31428254
3Elevated erythrocyte sedimentation rate (HP:0003565)5.14406403
4Recurrent fungal infections (HP:0002841)4.71151689
5T lymphocytopenia (HP:0005403)4.56137110
6Recurrent bacterial skin infections (HP:0005406)4.52717500
7Myositis (HP:0100614)4.44923068
8Abnormality of T cell number (HP:0011839)4.43173858
9IgM deficiency (HP:0002850)4.32754374
10Recurrent viral infections (HP:0004429)4.24739402
11Chronic mucocutaneous candidiasis (HP:0002728)4.08144810
12Recurrent cutaneous fungal infections (HP:0011370)4.08144810
13Chronic otitis media (HP:0000389)4.01584809
14Abnormality of T cells (HP:0002843)3.95699819
15Panhypogammaglobulinemia (HP:0003139)3.93930037
16Severe combined immunodeficiency (HP:0004430)3.91765269
17Recurrent bronchitis (HP:0002837)3.87672694
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.75135443
19Combined immunodeficiency (HP:0005387)3.75110248
20Recurrent skin infections (HP:0001581)3.71189293
21Mediastinal lymphadenopathy (HP:0100721)3.65557883
22Chronic obstructive pulmonary disease (HP:0006510)3.60474622
23Obstructive lung disease (HP:0006536)3.60474622
24Stomatitis (HP:0010280)3.60128158
25Thrombocytosis (HP:0001894)3.54204664
26Pustule (HP:0200039)3.52814343
27Nasal polyposis (HP:0100582)3.52073878
28Meningitis (HP:0001287)3.51841898
29Recurrent gram-negative bacterial infections (HP:0005420)3.47275152
30Hypochromic microcytic anemia (HP:0004840)3.44500707
31Thyroiditis (HP:0100646)3.39007737
32Abnormality of macrophages (HP:0004311)3.36654371
33Abnormality of T cell physiology (HP:0011840)3.28654988
34Keratoconjunctivitis (HP:0001096)3.28061287
35Hypochromic anemia (HP:0001931)3.26061252
36Abnormality of the nasal mucosa (HP:0000433)3.22725903
37Autoimmune thrombocytopenia (HP:0001973)3.20888631
38IgG deficiency (HP:0004315)3.11949372
39Leukocytosis (HP:0001974)3.09080585
40Abnormality of eosinophils (HP:0001879)3.07754659
41Spontaneous hematomas (HP:0007420)3.04964158
42Lymphopenia (HP:0001888)3.03724804
43Vasculitis (HP:0002633)3.03336735
44Eosinophilia (HP:0001880)2.99468329
45Inflammation of the large intestine (HP:0002037)2.99263088
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.96885827
47Petechiae (HP:0000967)2.96847144
48Orchitis (HP:0100796)2.94780819
49Gastrointestinal inflammation (HP:0004386)2.94077954
50Cellulitis (HP:0100658)2.90518871
51B lymphocytopenia (HP:0010976)2.89878449
52Abnormality of B cell number (HP:0010975)2.89878449
53Retrobulbar optic neuritis (HP:0100654)2.84590971
54Optic neuritis (HP:0100653)2.84590971
55Agammaglobulinemia (HP:0004432)2.84307028
56Prolonged bleeding time (HP:0003010)2.82754383
57Episodic fever (HP:0001954)2.79566234
58Granulocytopenia (HP:0001913)2.77673603
59Hemoptysis (HP:0002105)2.76151457
60Pulmonary embolism (HP:0002204)2.70647565
61Gingivitis (HP:0000230)2.70183761
62Vacuolated lymphocytes (HP:0001922)2.67817806
63Chronic diarrhea (HP:0002028)2.67153136
64Abnormality of the fingertips (HP:0001211)2.64809336
65Epistaxis (HP:0000421)2.59544936
66Anorexia (HP:0002039)2.57017897
67Encephalitis (HP:0002383)2.51721166
68Increased IgE level (HP:0003212)2.51109482
69Autoimmune hemolytic anemia (HP:0001890)2.46697032
70Hypergammaglobulinemia (HP:0010702)2.45596424
71Lymphoma (HP:0002665)2.44470168
72Periodontitis (HP:0000704)2.41487767
73Peritonitis (HP:0002586)2.40758157
74Hypoplasia of the thymus (HP:0000778)2.40330795
75Colitis (HP:0002583)2.40036585
76Recurrent sinusitis (HP:0011108)2.39316363
77Abnormality of the pleura (HP:0002103)2.38618232
78Interstitial pulmonary disease (HP:0006530)2.38316593
79Abnormality of cells of the erythroid lineage (HP:0012130)2.36951289
80Abnormal number of erythroid precursors (HP:0012131)2.36079091
81Pulmonary infiltrates (HP:0002113)2.34199335
82Gangrene (HP:0100758)2.26007909
83Cheilitis (HP:0100825)2.25691182
84Amyloidosis (HP:0011034)2.24509611
85Chest pain (HP:0100749)2.23324981
86IgA deficiency (HP:0002720)2.22660134
87Increased cerebral lipofuscin (HP:0011813)2.20560351
88Increased IgM level (HP:0003496)2.18752623
89Arterial thrombosis (HP:0004420)2.17471280
90Acute hepatic failure (HP:0006554)2.17293158
91Gingival bleeding (HP:0000225)2.15782923
92Gastrointestinal infarctions (HP:0005244)2.15327964
93Abnormality of the peritoneum (HP:0002585)2.14957454
94Abnormality of the prostate (HP:0008775)2.14426732
95Bronchitis (HP:0012387)2.13444568
96Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13110300
97Papilloma (HP:0012740)2.10817875
98Verrucae (HP:0200043)2.10817875
99Glomerulopathy (HP:0100820)2.10455511
100Skin ulcer (HP:0200042)2.08733027
101Urticaria (HP:0001025)2.08023895
102Basal ganglia calcification (HP:0002135)2.07865221
103Poikiloderma (HP:0001029)2.07859779
104Increased neuronal autofluorescent lipopigment (HP:0002074)2.07513554
105Abnormal platelet function (HP:0011869)2.06132040
106Impaired platelet aggregation (HP:0003540)2.06132040
107Keratoconjunctivitis sicca (HP:0001097)2.06064596
108Microcytic anemia (HP:0001935)2.05874323
109Gastrointestinal stroma tumor (HP:0100723)2.05451129
110Hepatosplenomegaly (HP:0001433)2.05235061
111Osteomyelitis (HP:0002754)2.04630308
112Reticulocytopenia (HP:0001896)2.03945370
113Purpura (HP:0000979)2.03375446
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03055993
115Premature loss of primary teeth (HP:0006323)2.02706249
116Viral hepatitis (HP:0006562)2.02400789
117Joint swelling (HP:0001386)2.02350554
118Sepsis (HP:0100806)1.99870430
119Skin rash (HP:0000988)1.97502113
120Vertigo (HP:0002321)1.95918970
121Recurrent pneumonia (HP:0006532)1.95800250
122Slow saccadic eye movements (HP:0000514)1.94500885
123Papilledema (HP:0001085)1.91462216
124Abnormality of the endocardium (HP:0004306)1.91332530
125Increased serum ferritin (HP:0003281)1.91175837
126Acne (HP:0001061)1.89786088

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.19319066
2TXK3.79043143
3TYK22.84452000
4JAK32.77640560
5ZAP702.73284714
6KIT2.62030967
7BLK2.60720530
8IKBKE2.44432939
9IRAK42.41704829
10TBK12.26008314
11PRPF4B2.18500813
12STK102.13552498
13BTK2.06948615
14FGFR42.06635388
15TEC2.05633432
16ITK2.05616814
17GRK62.02336711
18NME21.95272499
19JAK11.79737146
20MAP3K141.76419411
21RIPK41.74537684
22CSF1R1.70997960
23SYK1.70730906
24EEF2K1.67889510
25LCK1.62320151
26KDR1.59188145
27CSK1.56221485
28FLT31.51157804
29MAP3K101.47169409
30HCK1.43640058
31FGR1.41439616
32LRRK21.41369346
33MAP3K31.38872428
34TGFBR21.34890139
35FGFR31.34707767
36FES1.30606889
37NLK1.30423739
38PKN21.29491722
39MAP2K31.27225230
40MAP3K131.24465985
41IKBKB1.24013029
42CLK11.21123442
43ERN11.18678401
44TESK21.17860703
45PIM11.13996965
46LYN1.12584876
47MAP3K11.08989350
48IRAK31.06763107
49RPS6KA41.03317407
50SIK21.00864691
51TRIB30.98785199
52YES10.97894529
53MARK30.93937755
54JAK20.91804703
55MARK20.91803883
56EPHB10.90675479
57BMPR20.90409460
58PRKD20.89548525
59KSR20.88508264
60CDK190.82107619
61NEK20.82098164
62MATK0.81815300
63TAOK30.78458438
64IRAK10.76767234
65STK40.73666447
66CDK40.71822917
67PIM20.71770148
68MAPK120.71478166
69TNK20.71386377
70CAMKK10.70013048
71SMG10.69358507
72MST40.67828444
73PDPK10.63857257
74TAOK20.63315251
75MAPK70.62264758
76CHUK0.61405232
77PRKCH0.61014347
78MAP3K120.60030689
79PRKCQ0.59861558
80SCYL20.57387825
81MAP2K20.56472520
82IRAK20.56272300
83TGFBR10.56142324
84DYRK1B0.55490450
85CDC42BPA0.53945276
86STK110.52733190
87MAPK110.52246725
88ADRBK20.51953121
89PIK3CG0.51647425
90SIK30.51588012
91MAP3K110.51430094
92RPS6KB20.51372602
93CAMKK20.50804846
94PTK2B0.50781997
95MAP3K60.50561911
96EIF2AK30.48153378
97NEK90.46681499
98PDK10.46378558
99TRPM70.45957573
100MAP3K80.44659852
101HIPK20.41954732
102EPHA30.40981762
103MAP3K50.40828355
104TTN0.40593586
105STK380.40285363
106MAPK40.38754014
107ACVR1B0.38584759
108CDC70.37523419
109PAK40.37328661
110CDK60.36877198
111STK160.36561576
112DAPK20.36222384
113RET0.36049871
114RPS6KA60.35895224
115GRK70.35863660
116MAPKAPK20.35798053
117PTK60.35208672
118ILK0.35004585
119MAP3K20.34560080
120ABL10.34181401
121TLK10.33848391
122MAP3K70.33645867
123SIK10.33575403
124ALK0.32970576
125ATR0.32159656
126RPS6KA50.32068484
127PRKCD0.31277123
128EIF2AK10.30938867
129MAP2K40.30924097
130RAF10.30215741
131TAOK10.29969012
132MAP2K60.29684123
133SGK30.29354436
134WEE10.27815525
135RPS6KC10.26997839
136RPS6KL10.26997839
137MAPKAPK30.25467103
138FYN0.24588711

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.25808423
2Leishmaniasis_Homo sapiens_hsa051402.68264937
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.54148159
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.50116682
5Measles_Homo sapiens_hsa051622.48017783
6Antigen processing and presentation_Homo sapiens_hsa046122.41528291
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.37669861
8T cell receptor signaling pathway_Homo sapiens_hsa046602.30290749
9B cell receptor signaling pathway_Homo sapiens_hsa046622.22861620
10Osteoclast differentiation_Homo sapiens_hsa043802.20382318
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.17056001
12DNA replication_Homo sapiens_hsa030302.14173935
13Hematopoietic cell lineage_Homo sapiens_hsa046402.13079081
14Ribosome_Homo sapiens_hsa030102.07761609
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03149105
16Graft-versus-host disease_Homo sapiens_hsa053321.93123104
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89056549
18Allograft rejection_Homo sapiens_hsa053301.79678092
19Herpes simplex infection_Homo sapiens_hsa051681.77116008
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70877527
21Staphylococcus aureus infection_Homo sapiens_hsa051501.67903375
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65426024
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.64804970
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46433116
25Other glycan degradation_Homo sapiens_hsa005111.45609770
26Shigellosis_Homo sapiens_hsa051311.44618124
27Legionellosis_Homo sapiens_hsa051341.42413400
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40012267
29Toxoplasmosis_Homo sapiens_hsa051451.39331833
30Tuberculosis_Homo sapiens_hsa051521.37007979
31Acute myeloid leukemia_Homo sapiens_hsa052211.36583422
32Mismatch repair_Homo sapiens_hsa034301.35378704
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.35021262
34Influenza A_Homo sapiens_hsa051641.33763571
35Hepatitis B_Homo sapiens_hsa051611.31805771
36Viral myocarditis_Homo sapiens_hsa054161.31495214
37Chemokine signaling pathway_Homo sapiens_hsa040621.29446257
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28965899
39Pertussis_Homo sapiens_hsa051331.26726831
40Apoptosis_Homo sapiens_hsa042101.23499421
41Base excision repair_Homo sapiens_hsa034101.23472605
42Asthma_Homo sapiens_hsa053101.20861578
43Malaria_Homo sapiens_hsa051441.18341487
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15419461
45Non-homologous end-joining_Homo sapiens_hsa034501.06492138
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02942191
47Epstein-Barr virus infection_Homo sapiens_hsa051691.02662059
48TNF signaling pathway_Homo sapiens_hsa046681.01334444
49Spliceosome_Homo sapiens_hsa030400.99307583
50Platelet activation_Homo sapiens_hsa046110.97653139
51Salmonella infection_Homo sapiens_hsa051320.96762556
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.95184748
53Pancreatic cancer_Homo sapiens_hsa052120.95177586
54Chronic myeloid leukemia_Homo sapiens_hsa052200.93566335
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90252115
56Homologous recombination_Homo sapiens_hsa034400.90098143
57Caffeine metabolism_Homo sapiens_hsa002320.88053038
58Lysosome_Homo sapiens_hsa041420.87355054
59Autoimmune thyroid disease_Homo sapiens_hsa053200.86888686
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85151709
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84310638
62HTLV-I infection_Homo sapiens_hsa051660.84263501
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82759715
64Viral carcinogenesis_Homo sapiens_hsa052030.82375089
65Hepatitis C_Homo sapiens_hsa051600.80773819
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76677043
67Proteasome_Homo sapiens_hsa030500.76157731
68Nucleotide excision repair_Homo sapiens_hsa034200.75600344
69p53 signaling pathway_Homo sapiens_hsa041150.75320128
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72668632
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67896108
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65709286
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63894804
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63475072
75VEGF signaling pathway_Homo sapiens_hsa043700.62110591
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.62056490
77Pentose phosphate pathway_Homo sapiens_hsa000300.60163899
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.60044770
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59378565
80Colorectal cancer_Homo sapiens_hsa052100.59003241
81Regulation of autophagy_Homo sapiens_hsa041400.58966605
82Renal cell carcinoma_Homo sapiens_hsa052110.58805061
83Prolactin signaling pathway_Homo sapiens_hsa049170.58457825
84Pyrimidine metabolism_Homo sapiens_hsa002400.58377427
85Rheumatoid arthritis_Homo sapiens_hsa053230.57716678
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.57695535
87Non-small cell lung cancer_Homo sapiens_hsa052230.57205310
88Type I diabetes mellitus_Homo sapiens_hsa049400.57113807
89Choline metabolism in cancer_Homo sapiens_hsa052310.55545594
90Cell cycle_Homo sapiens_hsa041100.53718756
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.50398888
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50063125
93Notch signaling pathway_Homo sapiens_hsa043300.48214459
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47705960
95RNA degradation_Homo sapiens_hsa030180.47388623
96GnRH signaling pathway_Homo sapiens_hsa049120.47253566
97Inositol phosphate metabolism_Homo sapiens_hsa005620.44867889
98Endometrial cancer_Homo sapiens_hsa052130.44812710
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44785874
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44547769
101MAPK signaling pathway_Homo sapiens_hsa040100.44494988
102Small cell lung cancer_Homo sapiens_hsa052220.44414021
103Dorso-ventral axis formation_Homo sapiens_hsa043200.43220931
104Phagosome_Homo sapiens_hsa041450.42636019
105mTOR signaling pathway_Homo sapiens_hsa041500.40866886
106Endocytosis_Homo sapiens_hsa041440.38325382
107Systemic lupus erythematosus_Homo sapiens_hsa053220.36857096
108Amoebiasis_Homo sapiens_hsa051460.36690526
109RNA polymerase_Homo sapiens_hsa030200.35016306
110Fanconi anemia pathway_Homo sapiens_hsa034600.34810824
111African trypanosomiasis_Homo sapiens_hsa051430.34597283
112RNA transport_Homo sapiens_hsa030130.34354286
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.32951534
114Rap1 signaling pathway_Homo sapiens_hsa040150.32927753
115HIF-1 signaling pathway_Homo sapiens_hsa040660.32514970
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31658537
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28472252
118Type II diabetes mellitus_Homo sapiens_hsa049300.28324095
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27278388
120N-Glycan biosynthesis_Homo sapiens_hsa005100.26548412
121FoxO signaling pathway_Homo sapiens_hsa040680.26106685
122Thyroid cancer_Homo sapiens_hsa052160.25349701
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24484182
124Prostate cancer_Homo sapiens_hsa052150.24047153
125ErbB signaling pathway_Homo sapiens_hsa040120.23704840
126Insulin resistance_Homo sapiens_hsa049310.21839374

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