ARHGAP27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.10783734
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.10783734
3positive regulation of gamma-delta T cell activation (GO:0046645)5.97261986
4antigen processing and presentation of endogenous antigen (GO:0019883)5.80264103
5regulation of gamma-delta T cell differentiation (GO:0045586)5.27247132
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.20477026
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.09316261
8detection of other organism (GO:0098543)4.91983054
9detection of bacterium (GO:0016045)4.82680016
10regulation of gamma-delta T cell activation (GO:0046643)4.78793690
11regulation of B cell receptor signaling pathway (GO:0050855)4.67832527
12positive regulation of B cell differentiation (GO:0045579)4.59498013
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.50156651
14negative regulation of cell killing (GO:0031342)4.50156651
15positive thymic T cell selection (GO:0045059)4.47942645
16response to peptidoglycan (GO:0032494)4.40631673
17B cell receptor signaling pathway (GO:0050853)4.29370030
18detection of external biotic stimulus (GO:0098581)4.04489325
19negative regulation of interleukin-12 production (GO:0032695)4.02648763
20regulation of B cell differentiation (GO:0045577)4.01588807
21negative regulation of lymphocyte mediated immunity (GO:0002707)3.94575546
22antigen processing and presentation via MHC class Ib (GO:0002475)3.86096574
23regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.75499664
24negative thymic T cell selection (GO:0045060)3.74170407
25response to interleukin-15 (GO:0070672)3.74118176
26thymic T cell selection (GO:0045061)3.73121403
27regulation of interferon-beta biosynthetic process (GO:0045357)3.73101821
28negative regulation of erythrocyte differentiation (GO:0045647)3.69546777
29negative T cell selection (GO:0043383)3.67651994
30respiratory burst (GO:0045730)3.67025151
31leukocyte aggregation (GO:0070486)3.62125699
32detection of molecule of bacterial origin (GO:0032490)3.58481244
33negative regulation of leukocyte mediated immunity (GO:0002704)3.57647820
34angiogenesis involved in wound healing (GO:0060055)3.57563714
35regulation of mast cell degranulation (GO:0043304)3.57118833
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.55993467
37response to host immune response (GO:0052572)3.55993467
38detection of biotic stimulus (GO:0009595)3.52842466
39negative regulation of T cell mediated immunity (GO:0002710)3.51393741
40granulocyte activation (GO:0036230)3.50339669
41positive T cell selection (GO:0043368)3.45117718
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.45074597
43regulation of myeloid leukocyte mediated immunity (GO:0002886)3.45057530
44germinal center formation (GO:0002467)3.45020285
45T cell selection (GO:0045058)3.44829982
46regulation of interleukin-12 biosynthetic process (GO:0045075)3.43055112
47tolerance induction (GO:0002507)3.42821687
48immunoglobulin mediated immune response (GO:0016064)3.40647443
49regulation of dendritic cell antigen processing and presentation (GO:0002604)3.40306680
50hepatocyte apoptotic process (GO:0097284)3.39869256
51regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.36831390
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.34607383
53response to host (GO:0075136)3.34607383
54response to host defenses (GO:0052200)3.34607383
55regulation of tolerance induction (GO:0002643)3.33950416
56microglial cell activation (GO:0001774)3.32400709
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.31919477
58regulation of leukocyte degranulation (GO:0043300)3.31024224
59regulation of mast cell activation involved in immune response (GO:0033006)3.30009610
60leukocyte migration involved in inflammatory response (GO:0002523)3.27329396
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25779850
62macrophage activation (GO:0042116)3.25539238
63negative regulation of granulocyte differentiation (GO:0030853)3.20349712
64Arp2/3 complex-mediated actin nucleation (GO:0034314)3.20267179
65negative regulation of phagocytosis (GO:0050765)3.19699357
66mature B cell differentiation (GO:0002335)3.18482708
67interferon-gamma production (GO:0032609)3.16133562
68positive regulation of mast cell activation (GO:0033005)3.15173385
69cellular response to interleukin-15 (GO:0071350)3.14539951
70myeloid dendritic cell activation (GO:0001773)3.10931306
71positive regulation of antigen processing and presentation (GO:0002579)3.10899966
72negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.10138924
73antigen receptor-mediated signaling pathway (GO:0050851)3.08397731
74regulation of T cell tolerance induction (GO:0002664)3.07008175
75production of molecular mediator involved in inflammatory response (GO:0002532)3.05549432
76regulation of antigen processing and presentation (GO:0002577)3.04570889
77regulation of mast cell activation (GO:0033003)3.04277289
78megakaryocyte development (GO:0035855)3.03113643
79JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.02538150
80mast cell activation (GO:0045576)3.02514067
81positive regulation of lamellipodium assembly (GO:0010592)3.01730787
82definitive hemopoiesis (GO:0060216)3.01398954
83response to protozoan (GO:0001562)3.00635723
84regulation of T-helper 2 cell differentiation (GO:0045628)3.00030747
85leukocyte cell-cell adhesion (GO:0007159)2.99150255
86negative regulation of T-helper cell differentiation (GO:0045623)2.98110625
87negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.98110625
88macrophage activation involved in immune response (GO:0002281)2.97709979
89regulation of T cell mediated cytotoxicity (GO:0001914)2.96695734
90response to muramyl dipeptide (GO:0032495)2.95710975
91interferon-gamma-mediated signaling pathway (GO:0060333)2.95641113
92T cell homeostasis (GO:0043029)2.94937575
93positive regulation of histone deacetylation (GO:0031065)2.94736524
94lymphocyte homeostasis (GO:0002260)2.90157434
95NIK/NF-kappaB signaling (GO:0038061)2.90004624
96T cell migration (GO:0072678)2.89888095
97negative regulation of innate immune response (GO:0045824)2.89831986
98neutrophil mediated immunity (GO:0002446)2.89649501
99response to type I interferon (GO:0034340)2.89076833
100leukocyte degranulation (GO:0043299)2.89053708
101cellular extravasation (GO:0045123)2.89004377
102defense response to protozoan (GO:0042832)2.88921403
103endothelial tube morphogenesis (GO:0061154)2.86195631
104morphogenesis of an endothelium (GO:0003159)2.86195631
105mature B cell differentiation involved in immune response (GO:0002313)2.85395476
106lipopolysaccharide-mediated signaling pathway (GO:0031663)2.85002023
107negative regulation of interleukin-6 production (GO:0032715)2.84988518
108positive regulation of T cell mediated cytotoxicity (GO:0001916)2.83904334
109regulation of T cell receptor signaling pathway (GO:0050856)2.83348587
110ribosomal small subunit assembly (GO:0000028)2.83160501
111neutrophil activation involved in immune response (GO:0002283)2.83026332
112negative regulation of cytokine production involved in immune response (GO:0002719)2.83016255
113negative regulation of type 2 immune response (GO:0002829)2.82888583
114regulation of alpha-beta T cell proliferation (GO:0046640)2.81962179
115regulation of regulated secretory pathway (GO:1903305)2.81943392
116positive regulation of mast cell activation involved in immune response (GO:0033008)2.81857161
117positive regulation of mast cell degranulation (GO:0043306)2.81857161
118type I interferon signaling pathway (GO:0060337)2.81825456
119cellular response to type I interferon (GO:0071357)2.81825456
120positive regulation by symbiont of host defense response (GO:0052509)2.81718388
121modulation by symbiont of host defense response (GO:0052031)2.81718388
122modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81718388
123modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81718388
124positive regulation by organism of defense response of other organism involved in symbiotic interact2.81718388
125modulation by symbiont of host immune response (GO:0052553)2.81718388
126positive regulation of lamellipodium organization (GO:1902745)2.81088563
127myeloid cell activation involved in immune response (GO:0002275)2.80100160
128myeloid dendritic cell differentiation (GO:0043011)2.80048062
129regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74774693
130T cell receptor signaling pathway (GO:0050852)2.74452927
131natural killer cell differentiation (GO:0001779)2.73675075
132neutrophil activation (GO:0042119)2.72610744
133T cell costimulation (GO:0031295)2.71579276
134negative regulation of bone resorption (GO:0045779)2.70924375
135regulation of response to interferon-gamma (GO:0060330)2.69461546
136positive regulation of interferon-alpha production (GO:0032727)2.68741683
137cellular response to zinc ion (GO:0071294)2.67254125
138lymphocyte costimulation (GO:0031294)2.66078077
139response to laminar fluid shear stress (GO:0034616)2.65669783
140negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.65496158
141regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.64306864
142B cell homeostasis (GO:0001782)2.63344363
143B cell mediated immunity (GO:0019724)2.62641335
144immune response-activating cell surface receptor signaling pathway (GO:0002429)2.61981445
145positive regulation of macrophage differentiation (GO:0045651)2.61888768
146leukocyte homeostasis (GO:0001776)2.60259147
147regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59349317
148regulation of interferon-alpha production (GO:0032647)2.57300947
149regulation of granulocyte differentiation (GO:0030852)2.57272774
150regulation of erythrocyte differentiation (GO:0045646)2.56598474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.28898145
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.07379355
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.00471415
4MYC_22102868_ChIP-Seq_BL_Human3.55319658
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27001394
6VDR_21846776_ChIP-Seq_THP-1_Human3.24151074
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.07095200
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.02714954
9SCL_19346495_ChIP-Seq_HPC-7_Human3.00611808
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84546265
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79879193
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.66680676
13RUNX_20019798_ChIP-Seq_JUKART_Human2.62297926
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.59650050
15MAF_26560356_Chip-Seq_TH1_Human2.59357295
16* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58687365
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.54497537
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54139474
19TCF7_22412390_ChIP-Seq_EML_Mouse2.48274077
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.45136220
21VDR_24763502_ChIP-Seq_THP-1_Human2.44993201
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42010822
23* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41284646
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39947106
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38075912
26MYB_26560356_Chip-Seq_TH2_Human2.37225464
27UTX_26944678_Chip-Seq_JUKART_Human2.27077132
28STAT4_19710469_ChIP-ChIP_TH1__Mouse2.24783949
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.20750588
30E2F7_22180533_ChIP-Seq_HELA_Human2.19752908
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.19381335
32MYB_26560356_Chip-Seq_TH1_Human2.14122962
33BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13618516
34* SPI1_23547873_ChIP-Seq_NB4_Human2.07081428
35* RUNX1_22412390_ChIP-Seq_EML_Mouse2.04182608
36KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03052254
37TP63_17297297_ChIP-ChIP_HaCaT_Human2.02467279
38* SPI1_23127762_ChIP-Seq_K562_Human2.00241984
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.97050345
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88492497
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87574639
42* KDM2B_26808549_Chip-Seq_DND41_Human1.87329510
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.80927725
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72478862
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69932983
46GATA1_22025678_ChIP-Seq_K562_Human1.66661498
47MAF_26560356_Chip-Seq_TH2_Human1.59108547
48* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58426964
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54587495
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51467394
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47763600
52GATA3_27048872_Chip-Seq_THYMUS_Human1.46019264
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.45874204
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43529501
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42328935
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37591912
57LXR_22292898_ChIP-Seq_THP-1_Human1.36479237
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34347900
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.33357457
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32475841
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30624534
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27784906
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27565350
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27523450
65* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24941785
66* PU_27001747_Chip-Seq_BMDM_Mouse1.23774303
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.23746808
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23344572
69BCOR_27268052_Chip-Seq_Bcells_Human1.21172183
70* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19225182
71* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16325498
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.13785592
73* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12381445
74NCOR1_26117541_ChIP-Seq_K562_Human1.11664551
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11431644
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11341901
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.10649269
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10431369
79GATA1_19941826_ChIP-Seq_K562_Human1.09835306
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.09819247
81* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09242201
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07390542
83GATA2_19941826_ChIP-Seq_K562_Human1.05894849
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04909371
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04740949
86CIITA_25753668_ChIP-Seq_RAJI_Human1.04714981
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04542958
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04337426
89RACK7_27058665_Chip-Seq_MCF-7_Human1.03447085
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02210807
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98641258
92STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97907540
93* SA1_27219007_Chip-Seq_ERYTHROID_Human0.97706790
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96159083
95P68_20966046_ChIP-Seq_HELA_Human0.95440977
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94000577
97PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93652097
98VDR_24787735_ChIP-Seq_THP-1_Human0.91250571
99* ELF1_20517297_ChIP-Seq_JURKAT_Human0.90298455
100STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89438149
101KDM2B_26808549_Chip-Seq_K562_Human0.89296042
102* BCL6_27268052_Chip-Seq_Bcells_Human0.88469250
103PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88065603
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87767679
105RUNX1_27514584_Chip-Seq_MCF-7_Human0.87322745
106CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86964018
107* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86822327
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86816407
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86604996
110GATA3_26560356_Chip-Seq_TH2_Human0.86122088
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84913650
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.82680137
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81601117
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81097186
115GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80780220
116CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80764323
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80058858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.62216181
2MP0000685_abnormal_immune_system3.02355627
3MP0005671_abnormal_response_to2.99742455
4MP0001800_abnormal_humoral_immune2.89291548
5MP0002396_abnormal_hematopoietic_system2.79306210
6MP0003303_peritoneal_inflammation2.77412551
7MP0003300_gastrointestinal_ulcer2.68852112
8MP0003763_abnormal_thymus_physiology2.68488172
9MP0001873_stomach_inflammation2.67770493
10MP0001790_abnormal_immune_system2.67143866
11MP0005387_immune_system_phenotype2.67143866
12MP0002452_abnormal_antigen_presenting2.56606414
13MP0002420_abnormal_adaptive_immunity2.42656683
14MP0001819_abnormal_immune_cell2.40887669
15MP0005000_abnormal_immune_tolerance2.40425397
16MP0002723_abnormal_immune_serum2.39875494
17MP0009785_altered_susceptibility_to2.31765593
18MP0010155_abnormal_intestine_physiology2.30407611
19MP0002166_altered_tumor_susceptibility2.28768809
20MP0003866_abnormal_defecation2.27757112
21MP0003436_decreased_susceptibility_to2.26804965
22MP0005025_abnormal_response_to2.25426768
23MP0002398_abnormal_bone_marrow2.23627491
24MP0009278_abnormal_bone_marrow2.17891044
25MP0004510_myositis2.17273027
26MP0005464_abnormal_platelet_physiology2.11670182
27MP0002419_abnormal_innate_immunity2.09709976
28MP0000716_abnormal_immune_system2.04003096
29MP0000465_gastrointestinal_hemorrhage1.99178023
30MP0004808_abnormal_hematopoietic_stem1.98166149
31MP0002148_abnormal_hypersensitivity_rea1.92431560
32MP0002405_respiratory_system_inflammati1.90292085
33MP0004947_skin_inflammation1.89936272
34MP0000689_abnormal_spleen_morphology1.88476575
35MP0002722_abnormal_immune_system1.85821477
36MP0005397_hematopoietic_system_phenotyp1.85818990
37MP0001545_abnormal_hematopoietic_system1.85818990
38MP0009333_abnormal_splenocyte_physiolog1.82951806
39MP0003724_increased_susceptibility_to1.82775332
40MP0003191_abnormal_cellular_cholesterol1.76516739
41MP0008260_abnormal_autophagy1.76487923
42MP0002429_abnormal_blood_cell1.74119985
43MP0006082_CNS_inflammation1.72543353
44MP0010234_abnormal_vibrissa_follicle1.71761284
45MP0005451_abnormal_body_composition1.71113043
46MP0002006_tumorigenesis1.66923842
47MP0001845_abnormal_inflammatory_respons1.64329847
48MP0000703_abnormal_thymus_morphology1.57711352
49MP0005167_abnormal_blood-brain_barrier1.55860627
50MP0001853_heart_inflammation1.53564905
51MP0000490_abnormal_crypts_of1.50927283
52MP0002132_abnormal_respiratory_system1.44960194
53MP0003828_pulmonary_edema1.43953094
54MP0003566_abnormal_cell_adhesion1.41138334
55MP0001879_abnormal_lymphatic_vessel1.35269828
56MP0003183_abnormal_peptide_metabolism1.34424464
57MP0010352_gastrointestinal_tract_polyps1.34019537
58MP0005310_abnormal_salivary_gland1.30703897
59MP0004381_abnormal_hair_follicle1.28582498
60MP0010368_abnormal_lymphatic_system1.27205885
61MP0006054_spinal_hemorrhage1.20691317
62MP0001533_abnormal_skeleton_physiology1.18681076
63MP0005174_abnormal_tail_pigmentation1.17063908
64MP0004883_abnormal_blood_vessel1.16593390
65MP0008469_abnormal_protein_level1.16349400
66MP0001851_eye_inflammation1.14536821
67MP0001663_abnormal_digestive_system1.14127175
68MP0005058_abnormal_lysosome_morphology1.10224742
69MP0000858_altered_metastatic_potential1.09823763
70MP0003172_abnormal_lysosome_physiology1.09069786
71MP0003448_altered_tumor_morphology1.07261031
72MP0002933_joint_inflammation1.07187511
73MP0000343_altered_response_to1.04722172
74MP0003045_fibrosis1.04631466
75MP0008961_abnormal_basal_metabolism1.04487143
76MP0005023_abnormal_wound_healing1.01179914
77MP0002277_abnormal_respiratory_mucosa0.96712664
78MP0000249_abnormal_blood_vessel0.94243715
79MP0005164_abnormal_response_to0.93071454
80MP0005166_decreased_susceptibility_to0.93061864
81MP0003690_abnormal_glial_cell0.90869326
82MP0004264_abnormal_extraembryonic_tissu0.90077873
83MP0003453_abnormal_keratinocyte_physiol0.88190311
84MP0000477_abnormal_intestine_morphology0.86981390
85MP0005390_skeleton_phenotype0.86507934
86MP0003075_altered_response_to0.85593432
87MP0002998_abnormal_bone_remodeling0.85588685
88MP0002138_abnormal_hepatobiliary_system0.85457576
89MP0008004_abnormal_stomach_pH0.85086050
90MP0002019_abnormal_tumor_incidence0.84835786
91MP0009840_abnormal_foam_cell0.84691393
92MP0003091_abnormal_cell_migration0.83545820
93MP0002136_abnormal_kidney_physiology0.81456360
94MP0005076_abnormal_cell_differentiation0.80447759
95MP0009763_increased_sensitivity_to0.78111645
96MP0000604_amyloidosis0.74903963
97MP0003806_abnormal_nucleotide_metabolis0.73561913
98MP0000767_abnormal_smooth_muscle0.71183604
99MP0002928_abnormal_bile_duct0.68031878
100MP0002009_preneoplasia0.67172116
101MP0005381_digestive/alimentary_phenotyp0.66296511
102MP0009764_decreased_sensitivity_to0.65878493
103MP0001986_abnormal_taste_sensitivity0.64209510
104MP0003795_abnormal_bone_structure0.64113187
105MP0001958_emphysema0.63768862
106MP0010307_abnormal_tumor_latency0.63314849
107MP0001216_abnormal_epidermal_layer0.62138457
108MP0003279_aneurysm0.59073769
109MP0008874_decreased_physiological_sensi0.59024377
110MP0008873_increased_physiological_sensi0.58111882
111MP0005319_abnormal_enzyme/_coenzyme0.57762380
112MP0001191_abnormal_skin_condition0.57718696
113MP0009765_abnormal_xenobiotic_induced0.57191705
114MP0005165_increased_susceptibility_to0.56904176
115MP0003943_abnormal_hepatobiliary_system0.56468536
116MP0003705_abnormal_hypodermis_morpholog0.56302905
117MP0005083_abnormal_biliary_tract0.55272227
118MP0009643_abnormal_urine_homeostasis0.53501406
119MP0000609_abnormal_liver_physiology0.53351699
120MP0005360_urolithiasis0.53140885
121MP0005075_abnormal_melanosome_morpholog0.52514826
122MP0001765_abnormal_ion_homeostasis0.52389602
123MP0000015_abnormal_ear_pigmentation0.52114111
124MP0002254_reproductive_system_inflammat0.51353167

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.36797900
2Eczematoid dermatitis (HP:0000976)4.24253732
3Recurrent viral infections (HP:0004429)4.11398981
4Spontaneous hematomas (HP:0007420)4.07275318
5Recurrent abscess formation (HP:0002722)4.04983141
6Recurrent fungal infections (HP:0002841)4.04322774
7Chronic otitis media (HP:0000389)4.02192613
8Colitis (HP:0002583)3.96301780
9Inflammation of the large intestine (HP:0002037)3.91323901
10Hematochezia (HP:0002573)3.88506770
11Elevated erythrocyte sedimentation rate (HP:0003565)3.85786434
12Abnormality of the nasal mucosa (HP:0000433)3.85522286
13Gastrointestinal infarctions (HP:0005244)3.85083961
14Gastrointestinal inflammation (HP:0004386)3.79032013
15Recurrent bronchitis (HP:0002837)3.76537426
16Myositis (HP:0100614)3.66743771
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.65483893
18Recurrent bacterial skin infections (HP:0005406)3.59287715
19Cellulitis (HP:0100658)3.52910186
20Agammaglobulinemia (HP:0004432)3.50438567
21Keratoconjunctivitis sicca (HP:0001097)3.45695113
22Panhypogammaglobulinemia (HP:0003139)3.44705609
23Interstitial pulmonary disease (HP:0006530)3.42169718
24Chronic mucocutaneous candidiasis (HP:0002728)3.32226453
25Recurrent cutaneous fungal infections (HP:0011370)3.32226453
26Thrombocytosis (HP:0001894)3.31064524
27Abnormality of the fingertips (HP:0001211)3.28961299
28Keratoconjunctivitis (HP:0001096)3.25257083
29T lymphocytopenia (HP:0005403)3.22921210
30Autoimmune thrombocytopenia (HP:0001973)3.21966870
31Chronic diarrhea (HP:0002028)3.21385238
32Urticaria (HP:0001025)3.21220569
33Increased IgE level (HP:0003212)3.19768616
34Pustule (HP:0200039)3.15934017
35Abnormality of T cells (HP:0002843)3.11416913
36Abnormality of T cell number (HP:0011839)3.08771845
37B lymphocytopenia (HP:0010976)3.07819785
38Abnormality of B cell number (HP:0010975)3.07819785
39Nasal polyposis (HP:0100582)3.07778057
40Meningitis (HP:0001287)3.07277897
41Gastrointestinal stroma tumor (HP:0100723)3.06468669
42Lymphopenia (HP:0001888)3.00710353
43Abnormality of cells of the lymphoid lineage (HP:0012140)2.91932882
44Recurrent skin infections (HP:0001581)2.89233026
45Thyroiditis (HP:0100646)2.85553629
46Verrucae (HP:0200043)2.83929976
47Papilloma (HP:0012740)2.83929976
48Abnormality of T cell physiology (HP:0011840)2.82888167
49Petechiae (HP:0000967)2.81347478
50Vasculitis (HP:0002633)2.76394110
51Hypochromic anemia (HP:0001931)2.76346411
52Hypochromic microcytic anemia (HP:0004840)2.64961928
53Abnormality of macrophages (HP:0004311)2.60735417
54Episodic fever (HP:0001954)2.57655669
55Abnormal platelet function (HP:0011869)2.56975279
56Impaired platelet aggregation (HP:0003540)2.56975279
57Gingival bleeding (HP:0000225)2.56524596
58Cerebral aneurysm (HP:0004944)2.54654640
59Emphysema (HP:0002097)2.53796071
60Increased IgM level (HP:0003496)2.53742128
61Amyloidosis (HP:0011034)2.53549385
62Prolonged bleeding time (HP:0003010)2.53034480
63Systemic lupus erythematosus (HP:0002725)2.51334217
64Eosinophilia (HP:0001880)2.49081114
65Mediastinal lymphadenopathy (HP:0100721)2.46440417
66IgA deficiency (HP:0002720)2.44724777
67Pulmonary embolism (HP:0002204)2.41545426
68Obstructive lung disease (HP:0006536)2.40344695
69Chronic obstructive pulmonary disease (HP:0006510)2.40344695
70Severe combined immunodeficiency (HP:0004430)2.39407064
71Hemoptysis (HP:0002105)2.38203814
72Osteomyelitis (HP:0002754)2.37004854
73Anorexia (HP:0002039)2.36159931
74Malnutrition (HP:0004395)2.33875869
75Abnormality of eosinophils (HP:0001879)2.32251783
76Recurrent sinusitis (HP:0011108)2.31207375
77Orchitis (HP:0100796)2.28607395
78Granulocytopenia (HP:0001913)2.28289820
79Loss of speech (HP:0002371)2.25528105
80Increased neuronal autofluorescent lipopigment (HP:0002074)2.24808603
81Aortic aneurysm (HP:0004942)2.24633790
82Chronic sinusitis (HP:0011109)2.24367104
83IgG deficiency (HP:0004315)2.23442855
84Abnormality of the pleura (HP:0002103)2.23294027
85Premature loss of primary teeth (HP:0006323)2.23229294
86Skin ulcer (HP:0200042)2.23146701
87Polycythemia (HP:0001901)2.22919554
88Combined immunodeficiency (HP:0005387)2.22402086
89Leukocytosis (HP:0001974)2.21569345
90Chest pain (HP:0100749)2.19229418
91Peritonitis (HP:0002586)2.19036358
92Gangrene (HP:0100758)2.17983053
93Epistaxis (HP:0000421)2.17492661
94Abnormality of glycolipid metabolism (HP:0010969)2.17229618
95Abnormality of liposaccharide metabolism (HP:0010968)2.17229618
96Abnormality of glycosphingolipid metabolism (HP:0004343)2.17229618
97Sepsis (HP:0100806)2.11628879
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.10454586
99Restrictive lung disease (HP:0002091)2.10323278
100Stomatitis (HP:0010280)2.06984323
101Bronchitis (HP:0012387)2.06868792
102Bicuspid aortic valve (HP:0001647)2.05752144
103Dysostosis multiplex (HP:0000943)2.04407176
104Autoimmune hemolytic anemia (HP:0001890)2.03149944
105Increased serum ferritin (HP:0003281)2.01684598
106Purpura (HP:0000979)2.00866502
107Viral hepatitis (HP:0006562)2.00648759
108Fatigue (HP:0012378)1.99145713
109Cheilitis (HP:0100825)1.98619958
110Periodontitis (HP:0000704)1.97719778
111Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97396284
112Abnormality of the endocardium (HP:0004306)1.95808322
113Abnormality of the peritoneum (HP:0002585)1.95099708
114Hepatosplenomegaly (HP:0001433)1.94167294
115Vacuolated lymphocytes (HP:0001922)1.93631844
116Microcytic anemia (HP:0001935)1.93017201
117Arterial thrombosis (HP:0004420)1.92937129
118Gingivitis (HP:0000230)1.92674437
119Abnormality of iron homeostasis (HP:0011031)1.92578475
120Lymphoma (HP:0002665)1.92280616
121Glomerulopathy (HP:0100820)1.91757361
122Skin rash (HP:0000988)1.91305383
123Urethral obstruction (HP:0000796)1.89056778
124Increased cerebral lipofuscin (HP:0011813)1.86121214
125Encephalitis (HP:0002383)1.85803149
126Pulmonary infiltrates (HP:0002113)1.84997873
127Abnormal platelet volume (HP:0011876)1.84387485
128Hypergammaglobulinemia (HP:0010702)1.82586152
129Poikiloderma (HP:0001029)1.80027918
130Retrobulbar optic neuritis (HP:0100654)1.79139021
131Optic neuritis (HP:0100653)1.79139021
132Recurrent gram-negative bacterial infections (HP:0005420)1.75939935
133Ureteral stenosis (HP:0000071)1.75811545
134Facial diplegia (HP:0001349)1.73189767
135Recurrent pneumonia (HP:0006532)1.71894538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.04007937
2TGFBR23.85253119
3TYK22.59129362
4EEF2K2.57649869
5PRPF4B2.55667702
6STK102.29480476
7CSF1R2.23343525
8MAP3K102.21451148
9ERN12.19329273
10ZAP702.15903291
11TIE12.09090542
12BLK2.06797069
13KIT2.04403656
14TXK2.04143366
15GRK62.00563720
16PKN21.96781360
17JAK31.94416944
18BTK1.91629124
19KDR1.91111519
20TGFBR11.88779042
21TBK11.84034759
22ITK1.79353341
23LRRK21.77535040
24MAP2K31.67504130
25EPHB11.67434847
26JAK11.62700588
27TEC1.59696443
28SYK1.57534458
29RIPK41.56430897
30FGR1.51833434
31IKBKE1.49422081
32FES1.41122045
33SIK21.41091252
34TRIB31.40525169
35FGFR41.39136639
36HCK1.38048129
37MAP3K141.37538633
38LCK1.27371847
39PTK61.27265103
40MAP3K11.25318326
41CSK1.23628695
42IRAK41.23586322
43FLT31.22528949
44RIPK11.20874761
45PAK41.19733492
46MST41.19636907
47SMG11.18415408
48FGFR31.11983458
49MARK21.09630120
50MAP3K131.07011099
51NME21.04063688
52PRKD20.98437209
53CDC42BPA0.95435410
54PIM10.95282939
55IRAK30.94840374
56CLK10.94801580
57KSR20.93886818
58NLK0.92563590
59RPS6KA40.90747537
60LYN0.87650789
61YES10.87312591
62MARK30.85712470
63IRAK10.84697643
64PDPK10.84433226
65TTN0.83676313
66TESK20.83095629
67IKBKB0.82898669
68MATK0.82826852
69RPS6KB20.82155426
70PRKG20.80095667
71TAOK20.79838844
72MAP3K70.76825386
73PIM20.75784685
74JAK20.73784804
75BMPR20.73055121
76MAP2K20.70858293
77IRAK20.67326124
78DMPK0.66004656
79MAPKAPK30.65667731
80MAP3K60.65282584
81TAOK10.65108859
82CDK120.63604115
83TSSK60.63102304
84SCYL20.63030923
85SIK30.62614832
86MAP3K20.60979142
87PDK10.60943081
88MAP2K60.60907135
89TRPM70.60737745
90TNK20.60518187
91FYN0.59981951
92CAMK1D0.59235508
93MAP3K30.58226233
94CHUK0.57564171
95MAP3K80.57077163
96MAP3K110.55893172
97MAPK120.55326617
98CDK60.54967992
99DYRK1B0.54761849
100CDK40.53801760
101TAOK30.52671331
102PTK2B0.50402188
103RPS6KA60.48744005
104PRKCQ0.48283022
105MAPK40.43956554
106MAPK150.43420141
107CAMK1G0.42684184
108STK110.42213347
109EPHA30.42210201
110PRKCH0.42101136
111STK40.41876618
112RPS6KC10.40775006
113RPS6KL10.40775006
114ALK0.40757418
115MST1R0.40048653
116SGK30.38786009
117CDK190.38555800
118HIPK20.37557643
119STK380.36028633
120MAPKAPK20.35777624
121MAPK110.35526551
122BMX0.35356803
123MAP3K50.34535821
124CAMKK10.34159567
125EGFR0.31269606
126SIK10.31079896
127ICK0.30727326
128PDGFRB0.29245667
129MAPK70.28576968
130RET0.28511056
131PRKD10.28235119

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.66804284
2B cell receptor signaling pathway_Homo sapiens_hsa046623.00839076
3Osteoclast differentiation_Homo sapiens_hsa043802.51991445
4Autoimmune thyroid disease_Homo sapiens_hsa053202.41305455
5Leishmaniasis_Homo sapiens_hsa051402.39360513
6Hematopoietic cell lineage_Homo sapiens_hsa046402.19737655
7Antigen processing and presentation_Homo sapiens_hsa046122.12786629
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04543814
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.02752146
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.00328194
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.98102877
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.93972075
13T cell receptor signaling pathway_Homo sapiens_hsa046601.91779544
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.91088265
15Measles_Homo sapiens_hsa051621.90064527
16Type I diabetes mellitus_Homo sapiens_hsa049401.83725546
17Toxoplasmosis_Homo sapiens_hsa051451.76298472
18Asthma_Homo sapiens_hsa053101.69266794
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67603941
20Acute myeloid leukemia_Homo sapiens_hsa052211.61755036
21Other glycan degradation_Homo sapiens_hsa005111.60912241
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56365117
23Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.53578574
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.50693540
25Platelet activation_Homo sapiens_hsa046111.45803969
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43126507
27Shigellosis_Homo sapiens_hsa051311.43097576
28Influenza A_Homo sapiens_hsa051641.39139366
29Chronic myeloid leukemia_Homo sapiens_hsa052201.38431121
30Pertussis_Homo sapiens_hsa051331.36999213
31Chemokine signaling pathway_Homo sapiens_hsa040621.36929675
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35494406
33Herpes simplex infection_Homo sapiens_hsa051681.34013550
34Tuberculosis_Homo sapiens_hsa051521.32278152
35AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28612487
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.25381112
37Apoptosis_Homo sapiens_hsa042101.24910527
38Hepatitis B_Homo sapiens_hsa051611.24617347
39Viral myocarditis_Homo sapiens_hsa054161.22429994
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22029186
41Salmonella infection_Homo sapiens_hsa051321.18816537
42Phagosome_Homo sapiens_hsa041451.15780053
43Staphylococcus aureus infection_Homo sapiens_hsa051501.15584211
44VEGF signaling pathway_Homo sapiens_hsa043701.14506123
45TNF signaling pathway_Homo sapiens_hsa046681.12570280
46Pancreatic cancer_Homo sapiens_hsa052121.11351365
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06791719
48Legionellosis_Homo sapiens_hsa051341.02494471
49Rheumatoid arthritis_Homo sapiens_hsa053231.02320028
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.01829001
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01047572
52Notch signaling pathway_Homo sapiens_hsa043300.99206926
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93495060
54Small cell lung cancer_Homo sapiens_hsa052220.93190347
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92894296
56Non-small cell lung cancer_Homo sapiens_hsa052230.92476182
57Hepatitis C_Homo sapiens_hsa051600.91636994
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90686402
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.90670582
60HTLV-I infection_Homo sapiens_hsa051660.88553758
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84260164
62Malaria_Homo sapiens_hsa051440.80380923
63Colorectal cancer_Homo sapiens_hsa052100.80211717
64Thyroid cancer_Homo sapiens_hsa052160.78388904
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78172163
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75380005
67Allograft rejection_Homo sapiens_hsa053300.75357984
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75054195
69HIF-1 signaling pathway_Homo sapiens_hsa040660.73715411
70African trypanosomiasis_Homo sapiens_hsa051430.73565924
71Lysosome_Homo sapiens_hsa041420.73396043
72Epstein-Barr virus infection_Homo sapiens_hsa051690.72667250
73Ribosome_Homo sapiens_hsa030100.71003106
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70928603
75Endocytosis_Homo sapiens_hsa041440.70612979
76Prolactin signaling pathway_Homo sapiens_hsa049170.69646394
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69280811
78Rap1 signaling pathway_Homo sapiens_hsa040150.68058809
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67200348
80Caffeine metabolism_Homo sapiens_hsa002320.65028729
81Adherens junction_Homo sapiens_hsa045200.64895859
82Inositol phosphate metabolism_Homo sapiens_hsa005620.64375035
83Focal adhesion_Homo sapiens_hsa045100.63445512
84GnRH signaling pathway_Homo sapiens_hsa049120.63278021
85Viral carcinogenesis_Homo sapiens_hsa052030.62108225
86Insulin resistance_Homo sapiens_hsa049310.61924507
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.61719024
88Base excision repair_Homo sapiens_hsa034100.60781913
89Proteoglycans in cancer_Homo sapiens_hsa052050.59612018
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56192365
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53543673
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52963725
93Amoebiasis_Homo sapiens_hsa051460.52253996
94Renin-angiotensin system_Homo sapiens_hsa046140.51537868
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50990923
96Pathways in cancer_Homo sapiens_hsa052000.50709107
97Dorso-ventral axis formation_Homo sapiens_hsa043200.49351237
98FoxO signaling pathway_Homo sapiens_hsa040680.49185801
99mTOR signaling pathway_Homo sapiens_hsa041500.49132955
100DNA replication_Homo sapiens_hsa030300.48841501
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46709190
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46639297
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.45586373
104MAPK signaling pathway_Homo sapiens_hsa040100.44321114
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.43144286
106Renal cell carcinoma_Homo sapiens_hsa052110.41399340
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40497677
108Endometrial cancer_Homo sapiens_hsa052130.39208077
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39177976
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.37946925
111MicroRNAs in cancer_Homo sapiens_hsa052060.37556719
112Choline metabolism in cancer_Homo sapiens_hsa052310.37095947
113Type II diabetes mellitus_Homo sapiens_hsa049300.36697060
114Graft-versus-host disease_Homo sapiens_hsa053320.35668991
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35209711
116ErbB signaling pathway_Homo sapiens_hsa040120.32439965
117Gastric acid secretion_Homo sapiens_hsa049710.31721102
118Estrogen signaling pathway_Homo sapiens_hsa049150.31118457
119Insulin signaling pathway_Homo sapiens_hsa049100.29899913
120Arachidonic acid metabolism_Homo sapiens_hsa005900.29850387
121Bladder cancer_Homo sapiens_hsa052190.27478670

Most similar genes based on co-expression Upload to Enrichr

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