ARHGAP26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.43728046
2negative regulation of cell killing (GO:0031342)5.43728046
3positive regulation of gamma-delta T cell activation (GO:0046645)5.26290295
4positive regulation by symbiont of host defense response (GO:0052509)5.20158000
5modulation by symbiont of host defense response (GO:0052031)5.20158000
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.20158000
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.20158000
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.20158000
9modulation by symbiont of host immune response (GO:0052553)5.20158000
10synaptic vesicle exocytosis (GO:0016079)5.10258080
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.07482632
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.00163770
13macrophage activation involved in immune response (GO:0002281)4.91142635
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.89980072
15glutamate secretion (GO:0014047)4.75912261
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.75090735
17synaptic vesicle maturation (GO:0016188)4.72190839
18detection of molecule of bacterial origin (GO:0032490)4.71973123
19vocalization behavior (GO:0071625)4.68645097
20regulation of synaptic vesicle exocytosis (GO:2000300)4.64347569
21microglial cell activation (GO:0001774)4.64082230
22locomotory exploration behavior (GO:0035641)4.53747332
23regulation of B cell receptor signaling pathway (GO:0050855)4.46883841
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.37650998
25cellular extravasation (GO:0045123)4.34960221
26neurotransmitter-gated ion channel clustering (GO:0072578)4.34062972
27positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.25787283
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.23826991
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.20562378
30regulation of synaptic vesicle transport (GO:1902803)4.17155768
31neurotransmitter secretion (GO:0007269)4.16963899
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.11625142
33protein localization to synapse (GO:0035418)4.10788788
34regulation of glutamate receptor signaling pathway (GO:1900449)4.07282005
35neuronal action potential propagation (GO:0019227)4.03019860
36macrophage activation (GO:0042116)4.01552475
37neutrophil activation involved in immune response (GO:0002283)3.96675174
38detection of other organism (GO:0098543)3.95904609
39ionotropic glutamate receptor signaling pathway (GO:0035235)3.94331400
40regulation of gamma-delta T cell activation (GO:0046643)3.91280093
41detection of external biotic stimulus (GO:0098581)3.88228433
42negative regulation of interleukin-12 production (GO:0032695)3.85689006
43response to peptidoglycan (GO:0032494)3.81824110
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78441581
45regulation of interferon-beta biosynthetic process (GO:0045357)3.75615821
46synaptic transmission, glutamatergic (GO:0035249)3.74615408
47antigen processing and presentation of endogenous antigen (GO:0019883)3.74295483
48glutamate receptor signaling pathway (GO:0007215)3.71242830
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.67998069
50neuron-neuron synaptic transmission (GO:0007270)3.66028434
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.62465900
52regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.61899137
53response to host immune response (GO:0052572)3.60372202
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.60372202
55neutrophil mediated immunity (GO:0002446)3.57221544
56cerebellar Purkinje cell differentiation (GO:0021702)3.53939805
57regulation of gamma-delta T cell differentiation (GO:0045586)3.50484369
58neuron cell-cell adhesion (GO:0007158)3.49901411
59myeloid cell activation involved in immune response (GO:0002275)3.48882432
60regulation of voltage-gated calcium channel activity (GO:1901385)3.47800733
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.46658070
62detection of bacterium (GO:0016045)3.45369738
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45098656
64negative regulation of T cell mediated immunity (GO:0002710)3.44413254
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.44287030
66neutrophil activation (GO:0042119)3.44080072
67gamma-aminobutyric acid transport (GO:0015812)3.43928757
68detection of biotic stimulus (GO:0009595)3.43371740
69cellular potassium ion homeostasis (GO:0030007)3.43317638
70response to interleukin-15 (GO:0070672)3.42723210
71gamma-aminobutyric acid signaling pathway (GO:0007214)3.42274977
72regulation of synapse structural plasticity (GO:0051823)3.41668654
73response to histamine (GO:0034776)3.40889935
74regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38915200
75positive regulation of mast cell activation (GO:0033005)3.38255220
76exploration behavior (GO:0035640)3.37368616
77cerebellar granule cell differentiation (GO:0021707)3.36199591
78response to host (GO:0075136)3.35075339
79response to host defenses (GO:0052200)3.35075339
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.35075339
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33337799
82membrane depolarization during action potential (GO:0086010)3.30104208
83myeloid leukocyte mediated immunity (GO:0002444)3.28831058
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.28055920
85proline transport (GO:0015824)3.26629425
86long-term synaptic potentiation (GO:0060291)3.26460331
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.25646293
88negative regulation of leukocyte mediated immunity (GO:0002704)3.21804809
89regulation of postsynaptic membrane potential (GO:0060078)3.21757157
90neurotransmitter transport (GO:0006836)3.21080963
91cellular response to interleukin-15 (GO:0071350)3.17068046
92positive regulation of membrane potential (GO:0045838)3.16077313
93sodium ion export (GO:0071436)3.15920765
94presynaptic membrane assembly (GO:0097105)3.15569410
95long-term memory (GO:0007616)3.14938975
96regulation of neurotransmitter secretion (GO:0046928)3.13887203
97positive regulation of synaptic transmission, GABAergic (GO:0032230)3.12427363
98granulocyte activation (GO:0036230)3.10354462
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10255339
100respiratory burst (GO:0045730)3.09900870
101B cell receptor signaling pathway (GO:0050853)3.09762714
102synaptic vesicle endocytosis (GO:0048488)3.09094567
103leukocyte aggregation (GO:0070486)3.07786846
104regulation of synaptic transmission, glutamatergic (GO:0051966)3.07352533
105regulation of myeloid leukocyte mediated immunity (GO:0002886)3.05467600
106regulation of mast cell degranulation (GO:0043304)3.04508160
107activation of protein kinase A activity (GO:0034199)3.03996776
108postsynaptic membrane organization (GO:0001941)3.02208456
109germinal center formation (GO:0002467)3.01549025
110response to auditory stimulus (GO:0010996)2.99950004
111regulation of neurotransmitter levels (GO:0001505)2.99719627
112activated T cell proliferation (GO:0050798)2.99447525
113regulation of mast cell activation (GO:0033003)2.98686168
114response to muramyl dipeptide (GO:0032495)2.97091861
115positive regulation of mast cell degranulation (GO:0043306)2.96092336
116positive regulation of mast cell activation involved in immune response (GO:0033008)2.96092336
117negative regulation of dendrite morphogenesis (GO:0050774)2.95551926
118cell communication by electrical coupling (GO:0010644)2.94891399
119regulation of long-term neuronal synaptic plasticity (GO:0048169)2.94664428
120immunoglobulin mediated immune response (GO:0016064)2.94546620
121regulation of neuronal synaptic plasticity (GO:0048168)2.93743066
122regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.93479217
123regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93096794
124negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93063625
125membrane depolarization (GO:0051899)2.92236329
126positive regulation of neurotransmitter transport (GO:0051590)2.91731079
127negative thymic T cell selection (GO:0045060)2.89329309
128positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.88282844
129negative T cell selection (GO:0043383)2.88119192
130positive regulation of neurotransmitter secretion (GO:0001956)2.87883846
131positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.87869008
132presynaptic membrane organization (GO:0097090)2.87752101
133leukocyte migration involved in inflammatory response (GO:0002523)2.87750921
134regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.87521088
135regulation of mast cell activation involved in immune response (GO:0033006)2.87317382
136regulation of neurotransmitter transport (GO:0051588)2.85982608
137positive thymic T cell selection (GO:0045059)2.85384987
138positive regulation of synapse maturation (GO:0090129)2.84067798
139neuromuscular process controlling posture (GO:0050884)2.83506920
140regulation of synaptic plasticity (GO:0048167)2.83152326
141production of molecular mediator involved in inflammatory response (GO:0002532)2.81008747
142regulation of vesicle fusion (GO:0031338)2.80663391
143positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.79491357
144positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.79280747
145negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.76995042
146mechanosensory behavior (GO:0007638)2.76331059
147auditory behavior (GO:0031223)2.76040078
148regulation of leukocyte degranulation (GO:0043300)2.75916272
149regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.75362007
150positive regulation of cellular amide metabolic process (GO:0034250)2.75277375
151regulation of ARF protein signal transduction (GO:0032012)2.73949429
152positive regulation of synaptic transmission (GO:0050806)2.73915133
153negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.73713335
154interferon-gamma-mediated signaling pathway (GO:0060333)2.73526817
155regulation of T-helper 2 cell differentiation (GO:0045628)2.72632356
156synaptic transmission (GO:0007268)2.71749958
157regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.71663486
158positive T cell selection (GO:0043368)2.69803388
159regulation of regulated secretory pathway (GO:1903305)2.67450383
160glycine transport (GO:0015816)2.66585087
161myeloid leukocyte activation (GO:0002274)2.65209689
162cellular response to ethanol (GO:0071361)2.64813561
163regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.64395931
164defense response to protozoan (GO:0042832)2.64015199
165detection of calcium ion (GO:0005513)2.63684339
166cell differentiation in hindbrain (GO:0021533)2.63539072
167membrane hyperpolarization (GO:0060081)2.62682060
168long term synaptic depression (GO:0060292)2.62585656
169negative regulation of T-helper cell differentiation (GO:0045623)2.62171002
170negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.62171002
171regulation of cell communication by electrical coupling (GO:0010649)2.61542808
172lipopolysaccharide-mediated signaling pathway (GO:0031663)2.61453369
173antigen processing and presentation via MHC class Ib (GO:0002475)2.60895016
174regulation of beta-amyloid formation (GO:1902003)2.59993187
175leukocyte degranulation (GO:0043299)2.58905947
176positive regulation of toll-like receptor signaling pathway (GO:0034123)2.57234561
177dendritic cell migration (GO:0036336)2.56670967
178synapse assembly (GO:0007416)2.56431067
179T-helper 1 type immune response (GO:0042088)2.56360692
180negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.55226819
181positive regulation of potassium ion transmembrane transport (GO:1901381)2.54793980
182urinary tract smooth muscle contraction (GO:0014848)2.54612152
183positive regulation of interferon-alpha production (GO:0032727)2.54487054
184negative regulation of B cell mediated immunity (GO:0002713)2.54356754
185negative regulation of immunoglobulin mediated immune response (GO:0002890)2.54356754
186striatum development (GO:0021756)2.54002687
187negative regulation of adaptive immune response (GO:0002820)2.53766696
188regulation of tolerance induction (GO:0002643)2.53759026
189response to type I interferon (GO:0034340)2.53247783
190positive regulation of macrophage cytokine production (GO:0060907)2.53001769
191regulation of synapse maturation (GO:0090128)2.50473895
192regulation of synaptic transmission (GO:0050804)2.49050476
193regulation of synaptic transmission, GABAergic (GO:0032228)2.48880320
194negative regulation of dendrite development (GO:2000171)2.48457841
195behavioral response to cocaine (GO:0048148)2.47854443
196vesicle transport along microtubule (GO:0047496)2.45061519
197prepulse inhibition (GO:0060134)2.44738399
198establishment of synaptic vesicle localization (GO:0097480)2.43845477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.36120359
2EZH2_22144423_ChIP-Seq_EOC_Human4.26864253
3GBX2_23144817_ChIP-Seq_PC3_Human3.63110160
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.39925911
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.24483725
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.12440244
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.69754984
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63517545
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59829180
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56802571
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50248130
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.42870119
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42296070
14DROSHA_22980978_ChIP-Seq_HELA_Human2.39984062
15REST_21632747_ChIP-Seq_MESCs_Mouse2.39441257
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.36617574
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31589457
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19824929
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.15044728
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12142428
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12028409
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.08247257
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.08247257
24* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.06771978
25SCL_19346495_ChIP-Seq_HPC-7_Human2.05138223
26* SPI1_23127762_ChIP-Seq_K562_Human2.03659009
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01276406
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00682342
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99316953
30TAF15_26573619_Chip-Seq_HEK293_Human1.98826607
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.98312309
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97141584
33VDR_24787735_ChIP-Seq_THP-1_Human1.96548732
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95282642
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90751777
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.90652818
37* REST_18959480_ChIP-ChIP_MESCs_Mouse1.90411055
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86319003
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.85954332
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78756781
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78177979
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76385039
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75538730
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73703436
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.71272399
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.69056305
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.68272517
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.67929166
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63365434
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63322632
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62686006
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62490385
53P300_19829295_ChIP-Seq_ESCs_Human1.60023667
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57662465
55VDR_24763502_ChIP-Seq_THP-1_Human1.57269738
56MYB_26560356_Chip-Seq_TH2_Human1.57195151
57AR_21572438_ChIP-Seq_LNCaP_Human1.55352520
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52736811
59* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49832269
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47127030
61SPI1_23547873_ChIP-Seq_NB4_Human1.38985571
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.37209824
63AR_25329375_ChIP-Seq_VCAP_Human1.37101163
64GATA1_22025678_ChIP-Seq_K562_Human1.35862740
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.35263131
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34206847
67RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33474266
68GATA3_27048872_Chip-Seq_THYMUS_Human1.33428450
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33121086
70* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32844641
71* STAT3_23295773_ChIP-Seq_U87_Human1.30833620
72* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30639819
73BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30553881
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29061125
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28088932
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27808504
77* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27623647
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.26408710
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.25674260
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24260873
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23822167
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23058740
83* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22692468
84* TCF4_23295773_ChIP-Seq_U87_Human1.21915146
85* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20461177
86* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20230872
87AR_19668381_ChIP-Seq_PC3_Human1.18542086
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17312757
89* MYB_26560356_Chip-Seq_TH1_Human1.16623185
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.15751701
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14066903
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13735268
93GATA3_26560356_Chip-Seq_TH2_Human1.13152621
94MAF_26560356_Chip-Seq_TH1_Human1.12665734
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.12292650
96* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11428997
97AHR_22903824_ChIP-Seq_MCF-7_Human1.10749698
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10130693
99* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09260292
100* PRDM14_20953172_ChIP-Seq_ESCs_Human1.09250338
101* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09193700
102* SMAD3_21741376_ChIP-Seq_EPCs_Human1.08768591
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08000453
104GATA1_19941826_ChIP-Seq_K562_Human1.07763574
105RUNX_20019798_ChIP-Seq_JUKART_Human1.06056577
106TCF7_22412390_ChIP-Seq_EML_Mouse1.05778733
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05673247
108* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05316237
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05199054
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05089141
111IGF1R_20145208_ChIP-Seq_DFB_Human1.04955309
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04831887
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03603660
114PU_27001747_Chip-Seq_BMDM_Mouse1.03206584
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02895400
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02443708
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99932033
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99427423
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99064312
120NANOG_18555785_Chip-Seq_ESCs_Mouse0.98968892
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98187991
122GATA2_19941826_ChIP-Seq_K562_Human0.97676933
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97299825
124SMRT_27268052_Chip-Seq_Bcells_Human0.97118518
125* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96979968
126RXR_22108803_ChIP-Seq_LS180_Human0.96929633
127TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96032817
128* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94679166
129* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94216843
130ER_23166858_ChIP-Seq_MCF-7_Human0.93726123
131* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93128923
132GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93118267
133ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92769195
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.92539561
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.92491925
136TP53_16413492_ChIP-PET_HCT116_Human0.92464211
137FLI1_27457419_Chip-Seq_LIVER_Mouse0.92361252
138* SMAD3_21741376_ChIP-Seq_HESCs_Human0.91966812
139KDM2B_26808549_Chip-Seq_REH_Human0.91723596
140* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91694442
141RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91574966
142* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91001451
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90913035
144VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90517126
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90208847
146UTX_26944678_Chip-Seq_JUKART_Human0.90162928
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90103694
148BCAT_22108803_ChIP-Seq_LS180_Human0.89796197
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89536539
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88905102
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88905102
152* RUNX2_22187159_ChIP-Seq_PCA_Human0.88880274
153* SMAD3_21741376_ChIP-Seq_ESCs_Human0.88529727
154KDM2B_26808549_Chip-Seq_DND41_Human0.88382695
155MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88133719
156STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87521594
157RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87064544
158EGR1_19374776_ChIP-ChIP_THP-1_Human0.87020889
159KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86886192
160* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86381445
161* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85704701
162VDR_21846776_ChIP-Seq_THP-1_Human0.84708097
163NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84379887
164FOXO3_23340844_ChIP-Seq_DLD1_Human0.81619512
165FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79619797
166CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.78266074
167GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76712769
168STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.75862880
169* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75405802
170KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.75242112
171* FOXA2_19822575_ChIP-Seq_HepG2_Human0.69655631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.08826783
2MP0003724_increased_susceptibility_to4.67954303
3MP0003880_abnormal_central_pattern3.75563502
4MP0009046_muscle_twitch3.64452907
5MP0003635_abnormal_synaptic_transmissio3.62303330
6MP0001968_abnormal_touch/_nociception3.53824998
7MP0003436_decreased_susceptibility_to3.32589154
8MP0009745_abnormal_behavioral_response3.28974273
9MP0002064_seizures3.03925048
10MP0002736_abnormal_nociception_after3.01599812
11MP0002822_catalepsy2.95417241
12MP0004270_analgesia2.90193508
13MP0002063_abnormal_learning/memory/cond2.86922626
14MP0002419_abnormal_innate_immunity2.72319205
15MP0002735_abnormal_chemical_nociception2.65303980
16MP0002572_abnormal_emotion/affect_behav2.56362011
17MP0001800_abnormal_humoral_immune2.52917761
18MP0002734_abnormal_mechanical_nocicepti2.47490232
19MP0002272_abnormal_nervous_system2.46695498
20MP0005025_abnormal_response_to2.38609725
21MP0000685_abnormal_immune_system2.38337717
22MP0005000_abnormal_immune_tolerance2.27056833
23MP0006082_CNS_inflammation2.25843962
24MP0002723_abnormal_immune_serum2.22704698
25MP0001501_abnormal_sleep_pattern2.17564934
26MP0001486_abnormal_startle_reflex2.12436089
27MP0002067_abnormal_sensory_capabilities2.11658428
28MP0002452_abnormal_antigen_presenting2.10715216
29MP0002420_abnormal_adaptive_immunity2.07050066
30MP0001819_abnormal_immune_cell2.04746634
31MP0003300_gastrointestinal_ulcer2.03801512
32MP0008569_lethality_at_weaning1.97107905
33MP0001970_abnormal_pain_threshold1.89841692
34MP0004510_myositis1.88180293
35MP0005646_abnormal_pituitary_gland1.85891616
36MP0001984_abnormal_olfaction1.85696844
37MP0009780_abnormal_chondrocyte_physiolo1.84927930
38MP0002733_abnormal_thermal_nociception1.83396312
39MP0005386_behavior/neurological_phenoty1.82436858
40MP0004924_abnormal_behavior1.82436858
41MP0003646_muscle_fatigue1.81592828
42MP0003828_pulmonary_edema1.80176560
43MP0003191_abnormal_cellular_cholesterol1.78870895
44MP0001440_abnormal_grooming_behavior1.78033447
45MP0001533_abnormal_skeleton_physiology1.73486335
46MP0002837_dystrophic_cardiac_calcinosis1.71661085
47MP0005423_abnormal_somatic_nervous1.70918245
48MP0003763_abnormal_thymus_physiology1.68355777
49MP0003787_abnormal_imprinting1.67977150
50MP0001502_abnormal_circadian_rhythm1.66236819
51MP0004883_abnormal_blood_vessel1.65844851
52MP0003183_abnormal_peptide_metabolism1.65005472
53MP0003879_abnormal_hair_cell1.64936318
54MP0002909_abnormal_adrenal_gland1.55965526
55MP0005464_abnormal_platelet_physiology1.55321015
56MP0002405_respiratory_system_inflammati1.54842228
57MP0002876_abnormal_thyroid_physiology1.54804334
58MP0004215_abnormal_myocardial_fiber1.49254997
59MP0000716_abnormal_immune_system1.48486974
60MP0004947_skin_inflammation1.44213314
61MP0002398_abnormal_bone_marrow1.41754281
62MP0002557_abnormal_social/conspecific_i1.41504841
63MP0001845_abnormal_inflammatory_respons1.40839401
64MP0004381_abnormal_hair_follicle1.39355581
65MP0000569_abnormal_digit_pigmentation1.36913253
66MP0003633_abnormal_nervous_system1.34939786
67MP0002184_abnormal_innervation1.34732629
68MP0005451_abnormal_body_composition1.34630933
69MP0009764_decreased_sensitivity_to1.33061335
70MP0005164_abnormal_response_to1.32982120
71MP0000751_myopathy1.32219034
72MP0006276_abnormal_autonomic_nervous1.31497883
73MP0010155_abnormal_intestine_physiology1.30084053
74MP0004811_abnormal_neuron_physiology1.29773942
75MP0008872_abnormal_physiological_respon1.29701366
76MP0003329_amyloid_beta_deposits1.27684829
77MP0004742_abnormal_vestibular_system1.27383860
78MP0001851_eye_inflammation1.24806162
79MP0002166_altered_tumor_susceptibility1.23424307
80MP0005166_decreased_susceptibility_to1.22360800
81MP0004142_abnormal_muscle_tone1.20582675
82MP0002132_abnormal_respiratory_system1.20151457
83MP0005535_abnormal_body_temperature1.19480837
84MP0000465_gastrointestinal_hemorrhage1.17960134
85MP0002998_abnormal_bone_remodeling1.16799320
86MP0009278_abnormal_bone_marrow1.15260271
87MP0005645_abnormal_hypothalamus_physiol1.15243396
88MP0005551_abnormal_eye_electrophysiolog1.13870252
89MP0008874_decreased_physiological_sensi1.13378762
90MP0002277_abnormal_respiratory_mucosa1.13090376
91MP0002066_abnormal_motor_capabilities/c1.12752876
92MP0003631_nervous_system_phenotype1.12674600
93MP0005671_abnormal_response_to1.12076185
94MP0001835_abnormal_antigen_presentation1.11211695
95MP0000689_abnormal_spleen_morphology1.10643906
96MP0001188_hyperpigmentation1.10496903
97MP0000920_abnormal_myelination1.10039096
98MP0010386_abnormal_urinary_bladder1.09265772
99MP0002722_abnormal_immune_system1.09057570
100MP0001529_abnormal_vocalization1.06755227
101MP0008961_abnormal_basal_metabolism1.06742803
102MP0008469_abnormal_protein_level1.06206672
103MP0002429_abnormal_blood_cell1.03806666
104MP0004858_abnormal_nervous_system1.02360574
105MP0003656_abnormal_erythrocyte_physiolo0.99844804
106MP0000015_abnormal_ear_pigmentation0.97950878
107MP0005310_abnormal_salivary_gland0.96574109
108MP0000955_abnormal_spinal_cord0.94786064
109MP0002882_abnormal_neuron_morphology0.94719177
110MP0002332_abnormal_exercise_endurance0.94714983
111MP0002396_abnormal_hematopoietic_system0.94572065
112MP0000703_abnormal_thymus_morphology0.93369161
113MP0004036_abnormal_muscle_relaxation0.91470459
114MP0005174_abnormal_tail_pigmentation0.91044644
115MP0004130_abnormal_muscle_cell0.88849638
116MP0004484_altered_response_of0.88644656
117MP0001545_abnormal_hematopoietic_system0.87531710
118MP0005397_hematopoietic_system_phenotyp0.87531710
119MP0004145_abnormal_muscle_electrophysio0.87243200
120MP0004085_abnormal_heartbeat0.86389487
121MP0000858_altered_metastatic_potential0.85669721
122MP0003045_fibrosis0.85048527
123MP0002163_abnormal_gland_morphology0.83674222
124MP0001905_abnormal_dopamine_level0.83109699
125MP0004084_abnormal_cardiac_muscle0.81688394
126MP0002006_tumorigenesis0.80133103
127MP0001790_abnormal_immune_system0.79811516
128MP0005387_immune_system_phenotype0.79811516
129MP0001348_abnormal_lacrimal_gland0.79330577
130MP0003137_abnormal_impulse_conducting0.78631114
131MP0003690_abnormal_glial_cell0.78344729
132MP0003075_altered_response_to0.78081425
133MP0002069_abnormal_eating/drinking_beha0.77696955
134MP0000778_abnormal_nervous_system0.77332294
135MP0000604_amyloidosis0.77004142
136MP0008004_abnormal_stomach_pH0.76211300
137MP0002229_neurodegeneration0.75663259
138MP0009333_abnormal_splenocyte_physiolog0.75503572
139MP0002090_abnormal_vision0.75478463
140MP0000343_altered_response_to0.73919031
141MP0002148_abnormal_hypersensitivity_rea0.72289195
142MP0000249_abnormal_blood_vessel0.71333546
143MP0002638_abnormal_pupillary_reflex0.69572439
144MP0003303_peritoneal_inflammation0.67897299
145MP0003632_abnormal_nervous_system0.66434685
146MP0001986_abnormal_taste_sensitivity0.66369770
147MP0002972_abnormal_cardiac_muscle0.66125348
148MP0003172_abnormal_lysosome_physiology0.61078592
149MP0000013_abnormal_adipose_tissue0.59085499
150MP0005620_abnormal_muscle_contractility0.58936950
151MP0003866_abnormal_defecation0.57482896
152MP0009785_altered_susceptibility_to0.56935949
153MP0002152_abnormal_brain_morphology0.54543919
154MP0005167_abnormal_blood-brain_barrier0.53919740
155MP0008260_abnormal_autophagy0.53579905
156MP0005379_endocrine/exocrine_gland_phen0.52959784
157MP0005084_abnormal_gallbladder_morpholo0.52242844

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.44452859
2Febrile seizures (HP:0002373)5.73841842
3Eczematoid dermatitis (HP:0000976)5.55312947
4Epileptic encephalopathy (HP:0200134)5.50141104
5Recurrent bacterial skin infections (HP:0005406)5.43915256
6Myokymia (HP:0002411)5.33140585
7Atonic seizures (HP:0010819)5.24040063
8Focal seizures (HP:0007359)5.17549095
9Recurrent abscess formation (HP:0002722)5.11646477
10Myositis (HP:0100614)5.06019613
11Orchitis (HP:0100796)5.01792991
12Progressive cerebellar ataxia (HP:0002073)4.97638755
13Visual hallucinations (HP:0002367)4.52678396
14Dysmetric saccades (HP:0000641)4.36600688
15Recurrent gram-negative bacterial infections (HP:0005420)4.19236368
16Abnormality of macrophages (HP:0004311)4.16738503
17Absence seizures (HP:0002121)4.15137021
18Gaze-evoked nystagmus (HP:0000640)4.06251152
19Stomatitis (HP:0010280)4.02428913
20Hyperventilation (HP:0002883)3.96766742
21Recurrent fungal infections (HP:0002841)3.80954604
22Dialeptic seizures (HP:0011146)3.79952073
23Gastrointestinal infarctions (HP:0005244)3.76802467
24Elevated erythrocyte sedimentation rate (HP:0003565)3.76448352
25Generalized tonic-clonic seizures (HP:0002069)3.73286326
26Action tremor (HP:0002345)3.72884247
27Broad-based gait (HP:0002136)3.66544532
28Keratoconjunctivitis sicca (HP:0001097)3.59854176
29Recurrent skin infections (HP:0001581)3.59425732
30T lymphocytopenia (HP:0005403)3.51518688
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.42658838
32Mediastinal lymphadenopathy (HP:0100721)3.42007564
33Abnormality of T cell number (HP:0011839)3.40513066
34Keratoconjunctivitis (HP:0001096)3.37074061
35Gingivitis (HP:0000230)3.37011435
36Chronic mucocutaneous candidiasis (HP:0002728)3.33590911
37Recurrent cutaneous fungal infections (HP:0011370)3.33590911
38Spontaneous hematomas (HP:0007420)3.26010790
39Abnormal delayed hypersensitivity skin test (HP:0002963)3.24839252
40Genetic anticipation (HP:0003743)3.24789897
41Dysdiadochokinesis (HP:0002075)3.23081073
42Poor eye contact (HP:0000817)3.22829789
43Truncal ataxia (HP:0002078)3.19748157
44Meningitis (HP:0001287)3.16050125
45Abnormal hair whorl (HP:0010721)3.08401662
46Scanning speech (HP:0002168)3.04656750
47Vasculitis (HP:0002633)3.00332047
48Encephalitis (HP:0002383)2.98751131
49Impaired social interactions (HP:0000735)2.97882876
50Abnormal social behavior (HP:0012433)2.97882876
51Amyloidosis (HP:0011034)2.95192151
52Hemoptysis (HP:0002105)2.94764645
53Gingival bleeding (HP:0000225)2.86609389
54Postural instability (HP:0002172)2.86556075
55Urinary bladder sphincter dysfunction (HP:0002839)2.83291507
56Chest pain (HP:0100749)2.81007286
57Depression (HP:0000716)2.80737816
58Chronic obstructive pulmonary disease (HP:0006510)2.79904508
59Obstructive lung disease (HP:0006536)2.79904508
60Hemiplegia (HP:0002301)2.78980487
61Impaired smooth pursuit (HP:0007772)2.76214069
62Pulmonary infiltrates (HP:0002113)2.73184000
63Progressive inability to walk (HP:0002505)2.72736197
64Dysmetria (HP:0001310)2.72412594
65Arterial thrombosis (HP:0004420)2.70685535
66Pheochromocytoma (HP:0002666)2.69230016
67Peritonitis (HP:0002586)2.63678251
68Abnormal eating behavior (HP:0100738)2.60967401
69Urticaria (HP:0001025)2.60963387
70Leukocytosis (HP:0001974)2.58686729
71Slow saccadic eye movements (HP:0000514)2.58202733
72Abnormality of binocular vision (HP:0011514)2.57407023
73Diplopia (HP:0000651)2.57407023
74Episodic fever (HP:0001954)2.57121258
75Status epilepticus (HP:0002133)2.55894372
76Anxiety (HP:0000739)2.50553779
77Impaired vibration sensation in the lower limbs (HP:0002166)2.50263070
78Neuroendocrine neoplasm (HP:0100634)2.48540166
79Drooling (HP:0002307)2.48245911
80Excessive salivation (HP:0003781)2.48245911
81Pulmonary embolism (HP:0002204)2.47559690
82Epileptiform EEG discharges (HP:0011182)2.45252369
83Central scotoma (HP:0000603)2.41035991
84Prolonged bleeding time (HP:0003010)2.39336154
85Abnormality of T cells (HP:0002843)2.37370567
86Abnormality of ocular smooth pursuit (HP:0000617)2.36071039
87Vertigo (HP:0002321)2.35710936
88Prolonged QT interval (HP:0001657)2.35094760
89Epistaxis (HP:0000421)2.28821781
90Pustule (HP:0200039)2.28160803
91Cellulitis (HP:0100658)2.26180718
92Subacute progressive viral hepatitis (HP:0006572)2.25745500
93Ventricular fibrillation (HP:0001663)2.25400961
94Atrial fibrillation (HP:0005110)2.24723040
95Bundle branch block (HP:0011710)2.24691462
96EEG with generalized epileptiform discharges (HP:0011198)2.23725961
97Syncope (HP:0001279)2.23153358
98Recurrent viral infections (HP:0004429)2.22791242
99Failure to thrive in infancy (HP:0001531)2.22772877
100Abnormality of saccadic eye movements (HP:0000570)2.21051432
101Primary atrial arrhythmia (HP:0001692)2.20774684
102Protruding tongue (HP:0010808)2.20392268
103Ankle clonus (HP:0011448)2.19303860
104Blue irides (HP:0000635)2.18954392
105Abnormal EKG (HP:0003115)2.18778862
106Inflammation of the large intestine (HP:0002037)2.18637263
107Hypochromic microcytic anemia (HP:0004840)2.17543809
108Increased IgE level (HP:0003212)2.16331470
109Anorexia (HP:0002039)2.15979323
110Abnormality of the endocardium (HP:0004306)2.14936860
111Inability to walk (HP:0002540)2.14886119
112Supranuclear gaze palsy (HP:0000605)2.14620744
113Amblyopia (HP:0000646)2.14418082
114Retrobulbar optic neuritis (HP:0100654)2.13783810
115Optic neuritis (HP:0100653)2.13783810
116Osteomyelitis (HP:0002754)2.13358905
117Bradykinesia (HP:0002067)2.13159030
118Hypsarrhythmia (HP:0002521)2.08372737
119Hypochromic anemia (HP:0001931)2.06878408
120Torticollis (HP:0000473)2.06147661
121Gangrene (HP:0100758)2.05566098
122Sudden death (HP:0001699)2.05501551
123Impaired vibratory sensation (HP:0002495)2.04989841
124Supraventricular tachycardia (HP:0004755)2.02862753
125Polyphagia (HP:0002591)2.02646108
126Increased cerebral lipofuscin (HP:0011813)2.00614216
127Stomach cancer (HP:0012126)2.00527394
128Gastrointestinal inflammation (HP:0004386)1.99755292
129Generalized hypopigmentation of hair (HP:0011358)1.99459915
130Abnormality of the pleura (HP:0002103)1.99201382
131Fetal akinesia sequence (HP:0001989)1.98824572
132Mutism (HP:0002300)1.98503524
133Stereotypic behavior (HP:0000733)1.97981540
134Hemiparesis (HP:0001269)1.94819892
135Eosinophilia (HP:0001880)1.94414796
136Supraventricular arrhythmia (HP:0005115)1.93251597
137Memory impairment (HP:0002354)1.91601674
138Viral hepatitis (HP:0006562)1.88943353
139Colitis (HP:0002583)1.87216741
140Hypothermia (HP:0002045)1.87089182
141Limb ataxia (HP:0002070)1.86876543
142Oligomenorrhea (HP:0000876)1.86704885
143Focal dystonia (HP:0004373)1.86646783
144Spinal canal stenosis (HP:0003416)1.86407031
145Granulocytopenia (HP:0001913)1.86291447
146Papilledema (HP:0001085)1.85303351
147Bradycardia (HP:0001662)1.85238879
148Autoimmune thrombocytopenia (HP:0001973)1.84736138
149Difficulty running (HP:0009046)1.84706620
150Fair hair (HP:0002286)1.84083306
151Incomplete penetrance (HP:0003829)1.84056504
152Lower limb amyotrophy (HP:0007210)1.82372830
153Increased IgM level (HP:0003496)1.82271589
154Abnormality of the peritoneum (HP:0002585)1.81693453
155Recurrent bronchitis (HP:0002837)1.81288193
156Myotonia (HP:0002486)1.80916118
157Psychosis (HP:0000709)1.79894690
158Cheilitis (HP:0100825)1.79272193
159Neoplasm of the tracheobronchial system (HP:0100552)1.78477063
160Absent speech (HP:0001344)1.75848779
161Abnormality of the lower motor neuron (HP:0002366)1.74993453
162Sepsis (HP:0100806)1.74155065
163Abnormality of salivation (HP:0100755)1.73605215
164Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73397565
165Glomerulopathy (HP:0100820)1.72925968
166Exercise-induced myalgia (HP:0003738)1.71568791
167Gait ataxia (HP:0002066)1.70126137
168Abnormality of pain sensation (HP:0010832)1.69963452
169Impaired pain sensation (HP:0007328)1.69963452
170Intention tremor (HP:0002080)1.67243406
171Gait imbalance (HP:0002141)1.67181589
172Generalized myoclonic seizures (HP:0002123)1.67068762
173Hypoventilation (HP:0002791)1.66368739
174Left ventricular hypertrophy (HP:0001712)1.63557810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.74100470
2NTRK33.49386304
3MAP3K93.19476173
4BLK3.18732030
5MAP3K123.10122828
6DAPK22.95441554
7MAP2K72.77265908
8MAP3K42.74182632
9EPHA42.68661586
10IRAK42.48930170
11RIPK42.45514696
12MAP3K132.43587124
13MAP4K12.38851683
14CSK2.32839575
15SIK32.18310849
16MAP2K32.00730680
17DAPK11.91868456
18MAP3K141.91540041
19MAP2K41.87150256
20MINK11.78325582
21FGR1.76311719
22GRK61.73508830
23CAMKK21.71721733
24ZAP701.69651120
25NTRK21.69144611
26CDK191.67845328
27TAOK31.66124198
28SGK21.65992372
29CAMKK11.62873374
30ARAF1.55170244
31KSR21.53518675
32PAK61.53426930
33EPHB11.52181841
34PRPF4B1.50435637
35AKT31.42833367
36INSRR1.39970460
37SGK31.36464785
38BTK1.34554178
39SGK4941.33202616
40SGK2231.33202616
41HCK1.33013027
42MARK21.29239098
43STK381.27180344
44BMPR21.25544149
45NTRK11.24740513
46PLK21.24446999
47MAP3K111.22200968
48MAP3K31.21188729
49ERN11.20516073
50ITK1.16533192
51GRK51.16463257
52CDK51.13363802
53SIK21.12773396
54MARK11.11776562
55LYN1.11356692
56IRAK11.08956550
57KSR11.07750535
58PIK3CG1.06594651
59JAK11.03517270
60CSF1R1.02994808
61FES1.00666897
62LCK0.98426043
63YES10.93059021
64STK110.92489722
65PINK10.91011709
66FRK0.90219728
67MAPK130.89884062
68PRKCG0.87632556
69CAMK2A0.87083217
70KIT0.86227093
71SGK10.84765505
72TNK20.83141543
73TGFBR20.82833113
74IRAK20.82558501
75TEC0.81378530
76TBK10.81219898
77PHKG10.80423621
78PHKG20.80423621
79LMTK20.79622605
80PDK10.78260105
81CCNB10.78138946
82PRKCH0.78085239
83MARK30.76958454
84MATK0.76409456
85TNIK0.74923387
86RET0.73443108
87PTK60.71663010
88MAP3K10.70722304
89PRKCE0.68925621
90CAMK10.68271322
91FGFR30.67652812
92ACVR1B0.67510678
93CAMK40.67387850
94IKBKB0.65301012
95MAPK70.63963347
96WNK10.62303319
97SYK0.61917421
98RAF10.60927746
99MYLK0.59196781
100MAP3K70.59193222
101ERBB20.58696406
102PTK2B0.57123588
103PRKD30.56965208
104NLK0.56878667
105JAK20.56733248
106PDPK10.56718177
107BCR0.54494696
108PRKCQ0.53861262
109CDC42BPA0.53245866
110MUSK0.51642594
111IKBKE0.50665856
112TAOK10.50012096
113OXSR10.49972908
114MAP3K60.49588286
115TSSK60.49562714
116BRAF0.49514913
117GRK70.49436349
118RPS6KA20.48010976
119DAPK30.47200551
120MAP3K50.47001176
121RIPK10.46960043
122CDK180.46700764
123PAK30.46292864
124FGFR40.46188656
125PDGFRB0.45899393
126MAPK120.45235152
127CAMK1D0.42959967
128EPHA30.42048476
129CAMK2D0.41340496
130JAK30.41101890
131RPS6KA30.40984225
132NEK10.39974837
133CDK150.39498607
134FYN0.38157565
135RPS6KB10.37213207
136DMPK0.35155384
137TXK0.34218412
138CAMK2B0.32979390
139NEK60.32653616
140MAP3K20.32150306
141CDK140.32139316
142TYK20.31214611
143PRKCZ0.31048664

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.49355138
2Synaptic vesicle cycle_Homo sapiens_hsa047213.30213141
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51907966
4Circadian entrainment_Homo sapiens_hsa047132.42577665
5Morphine addiction_Homo sapiens_hsa050322.41643457
6GABAergic synapse_Homo sapiens_hsa047272.40319543
7Olfactory transduction_Homo sapiens_hsa047402.40308081
8Leishmaniasis_Homo sapiens_hsa051402.37448266
9Glutamatergic synapse_Homo sapiens_hsa047242.25069806
10Long-term potentiation_Homo sapiens_hsa047202.19777479
11Staphylococcus aureus infection_Homo sapiens_hsa051502.16073837
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07483404
13Salivary secretion_Homo sapiens_hsa049701.90250859
14Insulin secretion_Homo sapiens_hsa049111.87152742
15Amphetamine addiction_Homo sapiens_hsa050311.86194082
16Collecting duct acid secretion_Homo sapiens_hsa049661.86109664
17B cell receptor signaling pathway_Homo sapiens_hsa046621.83949483
18Dopaminergic synapse_Homo sapiens_hsa047281.69649021
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67420404
20Cholinergic synapse_Homo sapiens_hsa047251.66554515
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65839890
22Taste transduction_Homo sapiens_hsa047421.65119787
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63121539
24Renin secretion_Homo sapiens_hsa049241.56768854
25Gastric acid secretion_Homo sapiens_hsa049711.53572557
26Calcium signaling pathway_Homo sapiens_hsa040201.51522000
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44468988
28Long-term depression_Homo sapiens_hsa047301.44271735
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44172347
30Type II diabetes mellitus_Homo sapiens_hsa049301.43685741
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40313543
32Oxytocin signaling pathway_Homo sapiens_hsa049211.39832404
33Serotonergic synapse_Homo sapiens_hsa047261.38505166
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33776311
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28862829
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24669293
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24026165
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.22047558
39Malaria_Homo sapiens_hsa051441.21491392
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20184119
41Platelet activation_Homo sapiens_hsa046111.19902155
42Toxoplasmosis_Homo sapiens_hsa051451.18096659
43Measles_Homo sapiens_hsa051621.16694742
44Type I diabetes mellitus_Homo sapiens_hsa049401.13548361
45cAMP signaling pathway_Homo sapiens_hsa040241.12527095
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.10622293
47Legionellosis_Homo sapiens_hsa051341.10205771
48Cocaine addiction_Homo sapiens_hsa050301.09899393
49Influenza A_Homo sapiens_hsa051641.08482951
50Non-small cell lung cancer_Homo sapiens_hsa052231.08291625
51Hematopoietic cell lineage_Homo sapiens_hsa046401.05720602
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.04473034
53GnRH signaling pathway_Homo sapiens_hsa049121.04169362
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04094195
55Acute myeloid leukemia_Homo sapiens_hsa052211.01545443
56Primary immunodeficiency_Homo sapiens_hsa053401.01349885
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98623839
58Pancreatic secretion_Homo sapiens_hsa049720.97058434
59VEGF signaling pathway_Homo sapiens_hsa043700.96195289
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93581494
61Vibrio cholerae infection_Homo sapiens_hsa051100.93136645
62Circadian rhythm_Homo sapiens_hsa047100.91942831
63Antigen processing and presentation_Homo sapiens_hsa046120.91280464
64African trypanosomiasis_Homo sapiens_hsa051430.90280136
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90086329
66Rheumatoid arthritis_Homo sapiens_hsa053230.88340812
67Dilated cardiomyopathy_Homo sapiens_hsa054140.88102300
68Estrogen signaling pathway_Homo sapiens_hsa049150.83290930
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83262275
70Gap junction_Homo sapiens_hsa045400.82447211
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82168432
72Phototransduction_Homo sapiens_hsa047440.80865845
73Pertussis_Homo sapiens_hsa051330.80568261
74Chemokine signaling pathway_Homo sapiens_hsa040620.80519779
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80015505
76Cardiac muscle contraction_Homo sapiens_hsa042600.79528335
77Hepatitis B_Homo sapiens_hsa051610.79526213
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77392514
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.76815272
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.76627878
81Asthma_Homo sapiens_hsa053100.76075226
82Allograft rejection_Homo sapiens_hsa053300.74881473
83Glioma_Homo sapiens_hsa052140.74593143
84Hepatitis C_Homo sapiens_hsa051600.74326246
85Dorso-ventral axis formation_Homo sapiens_hsa043200.74241416
86Viral myocarditis_Homo sapiens_hsa054160.73240539
87Graft-versus-host disease_Homo sapiens_hsa053320.73067839
88ErbB signaling pathway_Homo sapiens_hsa040120.72893448
89Renal cell carcinoma_Homo sapiens_hsa052110.72757303
90Inositol phosphate metabolism_Homo sapiens_hsa005620.71665349
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71327585
92FoxO signaling pathway_Homo sapiens_hsa040680.70204280
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64054711
94MAPK signaling pathway_Homo sapiens_hsa040100.62964226
95Endocytosis_Homo sapiens_hsa041440.61334174
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60804253
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60715509
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.59249098
99Apoptosis_Homo sapiens_hsa042100.59165971
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58955440
101Nitrogen metabolism_Homo sapiens_hsa009100.58942805
102Herpes simplex infection_Homo sapiens_hsa051680.58639807
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.58473597
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58331695
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58167467
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54736509
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54532904
108Thyroid hormone synthesis_Homo sapiens_hsa049180.54273105
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50835214
110Osteoclast differentiation_Homo sapiens_hsa043800.47697085
111Glucagon signaling pathway_Homo sapiens_hsa049220.47633136
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47137183
113Prolactin signaling pathway_Homo sapiens_hsa049170.45980509
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44366862
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.43453436
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41780224
117mTOR signaling pathway_Homo sapiens_hsa041500.41671219
118TNF signaling pathway_Homo sapiens_hsa046680.41191176
119Tuberculosis_Homo sapiens_hsa051520.40833967
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40532873
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40435633
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39838751
123Bile secretion_Homo sapiens_hsa049760.38939455
124Choline metabolism in cancer_Homo sapiens_hsa052310.38808499
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37399133
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37155943
127Insulin signaling pathway_Homo sapiens_hsa049100.35375153
128Melanogenesis_Homo sapiens_hsa049160.34978944
129T cell receptor signaling pathway_Homo sapiens_hsa046600.34719424
130Autoimmune thyroid disease_Homo sapiens_hsa053200.34652393
131Ras signaling pathway_Homo sapiens_hsa040140.34474057
132Phagosome_Homo sapiens_hsa041450.34331385
133Arginine biosynthesis_Homo sapiens_hsa002200.34210595
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.33705156
135Axon guidance_Homo sapiens_hsa043600.33065066
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32287461
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32246237

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »