ARHGAP11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast cancer cell line. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.77542918
2mitotic chromosome condensation (GO:0007076)5.59128991
3mitotic sister chromatid segregation (GO:0000070)5.26889669
4sister chromatid segregation (GO:0000819)5.25022147
5mitotic sister chromatid cohesion (GO:0007064)5.21430280
6protein localization to chromosome, centromeric region (GO:0071459)5.19130512
7nuclear pore complex assembly (GO:0051292)5.13388047
8nuclear pore organization (GO:0006999)4.96100735
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.95983129
10DNA unwinding involved in DNA replication (GO:0006268)4.92605524
11mitotic metaphase plate congression (GO:0007080)4.71044373
12kinetochore organization (GO:0051383)4.50621441
13regulation of spindle organization (GO:0090224)4.46176630
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.38288714
15mitotic nuclear envelope disassembly (GO:0007077)4.36487120
16establishment of integrated proviral latency (GO:0075713)4.24376739
17metaphase plate congression (GO:0051310)4.17724987
18membrane disassembly (GO:0030397)4.09152099
19nuclear envelope disassembly (GO:0051081)4.09152099
20DNA ligation (GO:0006266)4.03906545
21positive regulation of mitotic sister chromatid separation (GO:1901970)4.02386384
22positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.02386384
23positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.02386384
24regulation of mitotic spindle organization (GO:0060236)4.02198033
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.99464711
26pore complex assembly (GO:0046931)3.99096149
27positive regulation of chromosome segregation (GO:0051984)3.98045788
28regulation of sister chromatid cohesion (GO:0007063)3.88674363
29attachment of spindle microtubules to kinetochore (GO:0008608)3.85325757
30establishment of chromosome localization (GO:0051303)3.85010050
31protein localization to chromosome (GO:0034502)3.83689738
32meiotic chromosome segregation (GO:0045132)3.79447006
33chromosome condensation (GO:0030261)3.71188104
34DNA replication initiation (GO:0006270)3.70472657
35kinetochore assembly (GO:0051382)3.70302984
36DNA replication checkpoint (GO:0000076)3.64437332
37regulation of RNA export from nucleus (GO:0046831)3.62521557
38DNA replication-dependent nucleosome assembly (GO:0006335)3.60217092
39DNA replication-dependent nucleosome organization (GO:0034723)3.60217092
40chromosome segregation (GO:0007059)3.59956003
41DNA geometric change (GO:0032392)3.58238996
42DNA duplex unwinding (GO:0032508)3.57390197
43DNA strand elongation involved in DNA replication (GO:0006271)3.54979095
44regulation of chromosome segregation (GO:0051983)3.54302112
45heterochromatin organization (GO:0070828)3.53849965
46regulation of translational fidelity (GO:0006450)3.52468926
47chromatin assembly or disassembly (GO:0006333)3.50441177
48DNA replication-independent nucleosome assembly (GO:0006336)3.46625354
49DNA replication-independent nucleosome organization (GO:0034724)3.46625354
50protein complex localization (GO:0031503)3.43810377
51double-strand break repair via nonhomologous end joining (GO:0006303)3.42706604
52non-recombinational repair (GO:0000726)3.42706604
53negative regulation of histone methylation (GO:0031061)3.41913948
54formation of translation preinitiation complex (GO:0001731)3.40063356
55regulation of histone H3-K9 methylation (GO:0051570)3.37462379
56spindle checkpoint (GO:0031577)3.36588996
57DNA strand elongation (GO:0022616)3.35767775
58DNA topological change (GO:0006265)3.35066030
59CENP-A containing nucleosome assembly (GO:0034080)3.34319396
60chromatin remodeling at centromere (GO:0031055)3.32440249
61regulation of DNA endoreduplication (GO:0032875)3.31614968
62nuclear envelope organization (GO:0006998)3.28462616
63mitotic recombination (GO:0006312)3.28408028
64DNA packaging (GO:0006323)3.27662822
65regulation of centrosome duplication (GO:0010824)3.27050596
66DNA conformation change (GO:0071103)3.26911068
67regulation of centrosome cycle (GO:0046605)3.26538844
68ribosome assembly (GO:0042255)3.23209879
69regulation of mitotic metaphase/anaphase transition (GO:0030071)3.22163815
70dosage compensation (GO:0007549)3.21936811
71DNA synthesis involved in DNA repair (GO:0000731)3.21299734
72translesion synthesis (GO:0019985)3.20980776
73chromatin assembly (GO:0031497)3.18200768
74cellular protein complex localization (GO:0034629)3.15985725
75regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.15654785
76spindle assembly checkpoint (GO:0071173)3.14933415
77mRNA stabilization (GO:0048255)3.14773692
78RNA stabilization (GO:0043489)3.14773692
79monoubiquitinated protein deubiquitination (GO:0035520)3.11941959
80mitotic cytokinesis (GO:0000281)3.10979131
81negative regulation of chromosome segregation (GO:0051985)3.10657285
82telomere maintenance via semi-conservative replication (GO:0032201)3.10078499
83mitotic cell cycle (GO:0000278)3.09609965
84pre-miRNA processing (GO:0031054)3.07921643
85establishment of viral latency (GO:0019043)3.07721851
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.07622579
87negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07289905
88DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.05719211
89telomere maintenance via recombination (GO:0000722)3.05236176
90telomere maintenance via telomere lengthening (GO:0010833)3.03812900
91regulation of sister chromatid segregation (GO:0033045)3.03431277
92regulation of mitotic sister chromatid separation (GO:0010965)3.03431277
93regulation of mitotic sister chromatid segregation (GO:0033047)3.03431277
94mitotic spindle organization (GO:0007052)3.02467998
95histone exchange (GO:0043486)3.01775422
96mitotic spindle assembly checkpoint (GO:0007094)3.01456073
97negative regulation of mitotic sister chromatid separation (GO:2000816)3.00897873
98negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00897873
99negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00897873
100negative regulation of sister chromatid segregation (GO:0033046)3.00897873
101ATP-dependent chromatin remodeling (GO:0043044)2.99836960
102spindle organization (GO:0007051)2.99792685
103histone-serine phosphorylation (GO:0035404)2.99479504
104folic acid-containing compound biosynthetic process (GO:0009396)2.99348029
105mitotic spindle checkpoint (GO:0071174)2.99045537
106microtubule depolymerization (GO:0007019)2.95439508
107chromosome organization (GO:0051276)2.94126137
108negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93099891
109sister chromatid cohesion (GO:0007062)2.92759247
110negative regulation of RNA splicing (GO:0033119)2.87177485
111regulation of centriole replication (GO:0046599)2.84665420
112mitotic DNA integrity checkpoint (GO:0044774)2.81970569
113DNA damage response, signal transduction resulting in transcription (GO:0042772)2.81070098
114maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79292468
115regulation of nucleobase-containing compound transport (GO:0032239)2.79229171
116spindle assembly involved in mitosis (GO:0090307)2.78395656
117protein K6-linked ubiquitination (GO:0085020)2.78102171
118microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.75141578
119mitotic G2/M transition checkpoint (GO:0044818)2.72692146

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human7.26190436
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.49604375
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.11301422
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.56516045
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.97436904
6AR_21909140_ChIP-Seq_LNCAP_Human2.82725393
7E2F1_21310950_ChIP-Seq_MCF-7_Human2.53845874
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52705026
9MYC_22102868_ChIP-Seq_BL_Human2.51134039
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.46781165
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20818070
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07473042
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04665276
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03219407
15E2F7_22180533_ChIP-Seq_HELA_Human10.9188159
16NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92716399
17TP63_19390658_ChIP-ChIP_HaCaT_Human1.91303170
18* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70810030
19XRN2_22483619_ChIP-Seq_HELA_Human1.69544945
20VDR_21846776_ChIP-Seq_THP-1_Human1.66025456
21MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65555830
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64725747
23CIITA_25753668_ChIP-Seq_RAJI_Human1.64173755
24* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61773308
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.55852246
26KDM5A_27292631_Chip-Seq_BREAST_Human1.55368566
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.50429749
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.43687588
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41825406
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38865272
31VDR_23849224_ChIP-Seq_CD4+_Human1.38257117
32* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34236835
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.32226095
34* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31781946
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31404780
36* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29388984
37TTF2_22483619_ChIP-Seq_HELA_Human1.28642269
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28050121
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.26790784
40KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25846521
41* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24628696
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23801944
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22462596
44* ELK1_19687146_ChIP-ChIP_HELA_Human1.20946009
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20522517
46* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20085487
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18792601
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18780667
49TFEB_21752829_ChIP-Seq_HELA_Human1.16003626
50GABP_19822575_ChIP-Seq_HepG2_Human1.15658362
51TCF7_22412390_ChIP-Seq_EML_Mouse1.14852434
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14632003
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12929437
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10854213
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.10331890
56CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09839248
57* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09122947
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08686642
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08264519
60* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07319450
61UTX_26944678_Chip-Seq_JUKART_Human1.05586489
62DCP1A_22483619_ChIP-Seq_HELA_Human1.04976092
63ZNF263_19887448_ChIP-Seq_K562_Human1.04578932
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04039606
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02697741
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02412210
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00540807
68* SOX17_20123909_ChIP-Seq_XEN_Mouse0.99886754
69SPI1_23547873_ChIP-Seq_NB4_Human0.99341444
70* MYB_26560356_Chip-Seq_TH1_Human0.98895362
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98778739
72* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98373798
73BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98369196
74PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98291841
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97703671
76MAF_26560356_Chip-Seq_TH1_Human0.97387686
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97321451
78ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96755759
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96548281
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96545901
81* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96167622
82GABP_17652178_ChIP-ChIP_JURKAT_Human0.95932137
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95253071
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94678311
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94245841
86ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94201838
87* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93103642
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92832786
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91953056
90* MYB_26560356_Chip-Seq_TH2_Human0.91110394
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91065599
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90952989
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89808948
94MYC_18940864_ChIP-ChIP_HL60_Human0.89708819
95* CHD1_26751641_Chip-Seq_LNCaP_Human0.88507335
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88411988
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88252682
98* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87178093
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87031823
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86667381
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84573096
102VDR_24763502_ChIP-Seq_THP-1_Human0.84158751
103ATF3_27146783_Chip-Seq_COLON_Human0.84007170
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83728650
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83498735
106RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83003127
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82117817
108RUNX1_22412390_ChIP-Seq_EML_Mouse0.82070535
109NCOR1_26117541_ChIP-Seq_K562_Human0.82049375
110KDM2B_26808549_Chip-Seq_DND41_Human0.80415674
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80140204
112THAP11_20581084_ChIP-Seq_MESCs_Mouse0.79953938
113ELK3_25401928_ChIP-Seq_HUVEC_Human0.79808694
114* NANOG_16153702_ChIP-ChIP_HESCs_Human0.79338080
115JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.79065241
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78967811
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.76503216
118YY1_21170310_ChIP-Seq_MESCs_Mouse0.76131809
119* SOX2_16153702_ChIP-ChIP_HESCs_Human0.73689620
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.72626568
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72561705
122EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.71140207
123SRF_21415370_ChIP-Seq_HL-1_Mouse0.69385392
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.68143219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.26500391
2MP0003111_abnormal_nucleus_morphology4.10596210
3MP0010094_abnormal_chromosome_stability4.00839999
4MP0003077_abnormal_cell_cycle3.63592394
5MP0008057_abnormal_DNA_replication3.41803770
6MP0004957_abnormal_blastocyst_morpholog3.24805111
7MP0010307_abnormal_tumor_latency2.69985014
8MP0010352_gastrointestinal_tract_polyps2.67568380
9MP0005076_abnormal_cell_differentiation2.44156660
10MP0002396_abnormal_hematopoietic_system2.42581020
11MP0008007_abnormal_cellular_replicative2.41178041
12MP0001730_embryonic_growth_arrest2.31085678
13MP0000350_abnormal_cell_proliferation2.28859915
14MP0003705_abnormal_hypodermis_morpholog2.20786782
15MP0009697_abnormal_copulation2.10441508
16MP0003123_paternal_imprinting2.02767141
17MP0008058_abnormal_DNA_repair1.99907046
18MP0004808_abnormal_hematopoietic_stem1.92998301
19MP0001672_abnormal_embryogenesis/_devel1.90381342
20MP0005380_embryogenesis_phenotype1.90381342
21MP0008932_abnormal_embryonic_tissue1.88403998
22MP0003984_embryonic_growth_retardation1.77917663
23MP0001697_abnormal_embryo_size1.75597440
24MP0002088_abnormal_embryonic_growth/wei1.74437158
25MP0000569_abnormal_digit_pigmentation1.72362487
26MP0009278_abnormal_bone_marrow1.72249832
27MP0002084_abnormal_developmental_patter1.67882463
28MP0002085_abnormal_embryonic_tissue1.64497991
29MP0002009_preneoplasia1.63345012
30MP0000490_abnormal_crypts_of1.63275245
31MP0002086_abnormal_extraembryonic_tissu1.61250021
32MP0003121_genomic_imprinting1.60490041
33MP0004197_abnormal_fetal_growth/weight/1.60243018
34MP0003941_abnormal_skin_development1.56522159
35MP0002080_prenatal_lethality1.50155115
36MP0005397_hematopoietic_system_phenotyp1.49390719
37MP0001545_abnormal_hematopoietic_system1.49390719
38MP0008877_abnormal_DNA_methylation1.48280205
39MP0003567_abnormal_fetal_cardiomyocyte1.42778192
40MP0002019_abnormal_tumor_incidence1.34237812
41MP0003890_abnormal_embryonic-extraembry1.33493784
42MP0002877_abnormal_melanocyte_morpholog1.28716571
43MP0000313_abnormal_cell_death1.28355134
44MP0009053_abnormal_anal_canal1.26588075
45MP0001849_ear_inflammation1.25716388
46MP0000733_abnormal_muscle_development1.23991894
47MP0010030_abnormal_orbit_morphology1.19313128
48MP0004233_abnormal_muscle_weight1.17648695
49MP0003566_abnormal_cell_adhesion1.17273973
50MP0000703_abnormal_thymus_morphology1.14080228
51MP0002398_abnormal_bone_marrow1.10456526
52MP0003937_abnormal_limbs/digits/tail_de1.09862220
53MP0003950_abnormal_plasma_membrane1.08918217
54MP0009333_abnormal_splenocyte_physiolog1.07028478
55MP0001915_intracranial_hemorrhage1.06884132
56MP0006292_abnormal_olfactory_placode1.06096085
57MP0003303_peritoneal_inflammation1.05106583
58MP0009672_abnormal_birth_weight1.02568509
59MP0004185_abnormal_adipocyte_glucose1.02393369
60MP0005501_abnormal_skin_physiology1.02377285
61MP0000358_abnormal_cell_content/1.00706217
62MP0003300_gastrointestinal_ulcer1.00501625
63MP0009703_decreased_birth_body0.99688373
64MP0000537_abnormal_urethra_morphology0.99233296
65MP0001661_extended_life_span0.98325933
66MP0000428_abnormal_craniofacial_morphol0.98132668
67MP0003786_premature_aging0.97763525
68MP0002722_abnormal_immune_system0.97023277
69MP0005023_abnormal_wound_healing0.96616503
70MP0005621_abnormal_cell_physiology0.93418728
71MP0001293_anophthalmia0.92939384
72MP0006054_spinal_hemorrhage0.92727488
73MP0004264_abnormal_extraembryonic_tissu0.91955836
74MP0000689_abnormal_spleen_morphology0.90790979
75MP0003787_abnormal_imprinting0.90682162
76MP0003315_abnormal_perineum_morphology0.87917647
77MP0000432_abnormal_head_morphology0.87617296
78MP0003385_abnormal_body_wall0.87393162
79MP0002925_abnormal_cardiovascular_devel0.86846298
80MP0003935_abnormal_craniofacial_develop0.85973361
81MP0005623_abnormal_meninges_morphology0.85585372
82MP0000858_altered_metastatic_potential0.85423156
83MP0003763_abnormal_thymus_physiology0.84273053
84MP0005257_abnormal_intraocular_pressure0.84151512
85MP0001929_abnormal_gametogenesis0.83729871
86MP0002092_abnormal_eye_morphology0.83316932
87MP0002796_impaired_skin_barrier0.82999122
88MP0003448_altered_tumor_morphology0.82933983
89MP0003115_abnormal_respiratory_system0.82577578
90MP0002210_abnormal_sex_determination0.81218163
91MP0005384_cellular_phenotype0.80349197
92MP0003943_abnormal_hepatobiliary_system0.78974959
93MP0002166_altered_tumor_susceptibility0.77448556
94MP0002697_abnormal_eye_size0.77241799
95MP0006035_abnormal_mitochondrial_morpho0.76245543
96MP0002429_abnormal_blood_cell0.75988181
97MP0003861_abnormal_nervous_system0.75922974
98MP0003221_abnormal_cardiomyocyte_apopto0.73085159
99MP0002060_abnormal_skin_morphology0.72262788
100MP0002006_tumorigenesis0.71765144
101MP0000716_abnormal_immune_system0.70923473
102MP0001800_abnormal_humoral_immune0.70401723
103MP0001145_abnormal_male_reproductive0.70128411
104MP0000762_abnormal_tongue_morphology0.69893597
105MP0003755_abnormal_palate_morphology0.68906942
106MP0002111_abnormal_tail_morphology0.68834791
107MP0000477_abnormal_intestine_morphology0.68647347
108MP0003091_abnormal_cell_migration0.67669590
109MP0001119_abnormal_female_reproductive0.65818208
110MP0002233_abnormal_nose_morphology0.65805404
111MP0003699_abnormal_female_reproductive0.65643455
112MP0003119_abnormal_digestive_system0.65113161
113MP0003718_maternal_effect0.64873457
114MP0001346_abnormal_lacrimal_gland0.64408302
115MP0000383_abnormal_hair_follicle0.64062618
116MP0001286_abnormal_eye_development0.63882025
117MP0010234_abnormal_vibrissa_follicle0.63427179
118MP0008770_decreased_survivor_rate0.63295922
119MP0000653_abnormal_sex_gland0.63149884
120MP0001727_abnormal_embryo_implantation0.63029420
121MP0000627_abnormal_mammary_gland0.62663899
122MP0002452_abnormal_antigen_presenting0.62176024
123MP0005187_abnormal_penis_morphology0.62054097
124MP0000266_abnormal_heart_morphology0.60964310
125MP0002234_abnormal_pharynx_morphology0.59567553
126MP0001299_abnormal_eye_distance/0.59278008
127MP0004272_abnormal_basement_membrane0.59195126
128MP0002114_abnormal_axial_skeleton0.58603160
129MP0001881_abnormal_mammary_gland0.58292690
130MP0003942_abnormal_urinary_system0.57795911
131MP0002081_perinatal_lethality0.57128632
132MP0001216_abnormal_epidermal_layer0.56619448
133MP0002177_abnormal_outer_ear0.56181843
134MP0002938_white_spotting0.55795742

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.80445859
2Volvulus (HP:0002580)3.67502547
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50304015
4Cortical dysplasia (HP:0002539)3.44104740
5Embryonal renal neoplasm (HP:0011794)3.30082300
6Abnormality of chromosome stability (HP:0003220)3.09425455
7Increased nuchal translucency (HP:0010880)3.07961412
8Short 4th metacarpal (HP:0010044)3.06941709
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.06941709
10Ectopic kidney (HP:0000086)3.03196946
11Abnormal lung lobation (HP:0002101)2.95499616
12Abnormality of the fingertips (HP:0001211)2.90217122
13Ependymoma (HP:0002888)2.79608657
14Deviation of the thumb (HP:0009603)2.73233508
15Impulsivity (HP:0100710)2.71162920
16Proximal placement of thumb (HP:0009623)2.70079391
17Meckel diverticulum (HP:0002245)2.62719598
18Patellar aplasia (HP:0006443)2.62622997
19Birth length less than 3rd percentile (HP:0003561)2.60438961
20Medulloblastoma (HP:0002885)2.59461063
21Prominent nose (HP:0000448)2.57985460
22Facial hemangioma (HP:0000329)2.55935733
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.53284052
24Long eyelashes (HP:0000527)2.51321669
25Myelodysplasia (HP:0002863)2.51110560
26Abnormality of the ileum (HP:0001549)2.46587307
27Abnormality of the preputium (HP:0100587)2.44629256
28Missing ribs (HP:0000921)2.43295033
29Aplasia/Hypoplasia of the patella (HP:0006498)2.42819356
30Selective tooth agenesis (HP:0001592)2.33953602
31Abnormality of the astrocytes (HP:0100707)2.32688842
32Astrocytoma (HP:0009592)2.32688842
33Small intestinal stenosis (HP:0012848)2.31086551
34Duodenal stenosis (HP:0100867)2.31086551
35Multiple enchondromatosis (HP:0005701)2.26593970
36Colon cancer (HP:0003003)2.25609871
37Abnormality of the carotid arteries (HP:0005344)2.22679556
38Cafe-au-lait spot (HP:0000957)2.22082331
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.21806730
40Rhabdomyosarcoma (HP:0002859)2.18617064
41High pitched voice (HP:0001620)2.17801671
42Microvesicular hepatic steatosis (HP:0001414)2.17790695
43Ankyloglossia (HP:0010296)2.17041858
44Embryonal neoplasm (HP:0002898)2.10852021
45Abnormality of the 4th metacarpal (HP:0010012)2.10581680
46Abnormality of the labia minora (HP:0012880)2.10490628
47Progressive external ophthalmoplegia (HP:0000590)2.09563337
48Choanal atresia (HP:0000453)2.08422468
49Agnosia (HP:0010524)2.08101408
50Malignant gastrointestinal tract tumors (HP:0006749)2.07610016
51Gastrointestinal carcinoma (HP:0002672)2.07610016
52Progressive muscle weakness (HP:0003323)2.07605259
53High anterior hairline (HP:0009890)2.06776476
54Breast hypoplasia (HP:0003187)2.06329484
55Neoplasm of the colon (HP:0100273)2.04565870
56Horseshoe kidney (HP:0000085)2.02088652
57Insomnia (HP:0100785)2.01828283
58Hyperacusis (HP:0010780)2.01106660
59Acute myeloid leukemia (HP:0004808)2.01009698
60Duplication of thumb phalanx (HP:0009942)2.00451166
61Atresia of the external auditory canal (HP:0000413)1.99551266
62Sparse lateral eyebrow (HP:0005338)1.98981511
63Heterotopia (HP:0002282)1.97142205
64Glioma (HP:0009733)1.96742236
65Insidious onset (HP:0003587)1.95966603
66Termporal pattern (HP:0011008)1.95966603
67Sloping forehead (HP:0000340)1.95916563
68Poikiloderma (HP:0001029)1.93577732
69Syringomyelia (HP:0003396)1.92556281
70Spinal cord lesions (HP:0100561)1.92556281
71Overlapping toe (HP:0001845)1.91892775
72Reticulocytopenia (HP:0001896)1.91622179
73Basal cell carcinoma (HP:0002671)1.90837658
74Abnormality of the duodenum (HP:0002246)1.89837400
75Neoplasm of the oral cavity (HP:0100649)1.88748490
76Abnormal umbilical cord blood vessels (HP:0011403)1.86956993
77Single umbilical artery (HP:0001195)1.86956993
78Abnormality of the fetal cardiovascular system (HP:0010948)1.86956993
79Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.86871632
80Abnormality of chromosome segregation (HP:0002916)1.86434049
81Cutis marmorata (HP:0000965)1.85396365
82Abnormality of the umbilical cord (HP:0010881)1.85215339
83Ulnar bowing (HP:0003031)1.84776335
84Triphalangeal thumb (HP:0001199)1.84211413
85Blepharitis (HP:0000498)1.84160868
86Abnormality of oral frenula (HP:0000190)1.82307015
87Broad thumb (HP:0011304)1.82185064
8811 pairs of ribs (HP:0000878)1.82045336
89Duplicated collecting system (HP:0000081)1.81950138
90Absent radius (HP:0003974)1.81602395
91Neoplasm of striated muscle (HP:0009728)1.80289836
92Tracheoesophageal fistula (HP:0002575)1.79044114
93Microglossia (HP:0000171)1.79037277
94Clubbing of toes (HP:0100760)1.78471321
95Deep philtrum (HP:0002002)1.77777618
96Squamous cell carcinoma (HP:0002860)1.76559616
97Sandal gap (HP:0001852)1.76068808
98Abnormal number of incisors (HP:0011064)1.75946344
99Orthostatic hypotension (HP:0001278)1.75232990
100Renal duplication (HP:0000075)1.74733890
101Cutaneous melanoma (HP:0012056)1.73941858
102Short thumb (HP:0009778)1.73574704
103Abnormality of DNA repair (HP:0003254)1.73067861
104Increased density of long bones (HP:0006392)1.72224985
105Trigonocephaly (HP:0000243)1.70513940
106Uterine leiomyosarcoma (HP:0002891)1.69513987
107Leiomyosarcoma (HP:0100243)1.69513987
108Urethral obstruction (HP:0000796)1.69458919
109Microtia (HP:0008551)1.69272732
110Absent thumb (HP:0009777)1.68180801
111Cellulitis (HP:0100658)1.68071471
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.67671869
113Osteolytic defects of the hand bones (HP:0009699)1.67671869
114Absent forearm bone (HP:0003953)1.66329091
115Aplasia involving forearm bones (HP:0009822)1.66329091
116Transitional cell carcinoma of the bladder (HP:0006740)1.66194641
117Arteriovenous malformation (HP:0100026)1.66052401
118Papillary thyroid carcinoma (HP:0002895)1.65997663
119Entropion (HP:0000621)1.65707226
120Aplasia/Hypoplasia of the sternum (HP:0006714)1.65183464
121Lip pit (HP:0100267)1.64996842
122Bone marrow hypocellularity (HP:0005528)1.64856079
123Truncal obesity (HP:0001956)1.64436267
124Thrombocytosis (HP:0001894)1.64346557
125Skin tags (HP:0010609)1.64049258
126Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63770710
127Neoplasm of the pancreas (HP:0002894)1.63478244
128Broad palm (HP:0001169)1.62918758
129Abnormality of glycolysis (HP:0004366)1.62010232
130Obsessive-compulsive behavior (HP:0000722)1.61857314
131Nephroblastoma (Wilms tumor) (HP:0002667)1.61755051
132Biliary tract neoplasm (HP:0100574)1.61623850
133Asymmetry of the thorax (HP:0001555)1.61613298
134Low anterior hairline (HP:0000294)1.61293367
135Overriding aorta (HP:0002623)1.60522999
136Broad phalanges of the hand (HP:0009768)1.59893530
137Capillary hemangiomas (HP:0005306)1.59661518
138Abnormality of cochlea (HP:0000375)1.57431110
139Abnormality of the calcaneus (HP:0008364)1.55732074
140Hypoplastic pelvis (HP:0008839)1.54460701
141Elfin facies (HP:0004428)1.54369424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.76079695
2CDK123.93599847
3NEK23.63343526
4LATS13.38339869
5PBK2.88653002
6WEE12.66109214
7EEF2K2.59414489
8BUB12.58963749
9TTK2.37619796
10STK102.16260888
11STK32.05385264
12PKN21.99827747
13MAP3K101.91367844
14LATS21.89721025
15NEK11.84076558
16CDK41.80925292
17AURKB1.75369512
18BRSK21.75096677
19CHEK21.74324347
20PLK11.69975183
21TRIB31.66916637
22PLK41.62080752
23SRPK11.61739353
24CDK61.59952577
25SMG11.55294851
26CDK71.54414951
27ATR1.50847099
28TAF11.49266953
29STK38L1.49081751
30MST1R1.47198337
31RPS6KB21.45340676
32RPS6KA41.43732105
33CHEK11.41492045
34MAP3K81.39248480
35STK41.33113817
36ZAK1.32579962
37BRD41.28404619
38PLK31.25395131
39BRSK11.22769383
40MKNK11.22305437
41MELK1.20923798
42TESK21.19334923
43VRK21.13961142
44MST41.13473254
45ERBB41.12197750
46ATM1.11489730
47BRAF1.11042074
48PASK1.08324766
49EIF2AK11.06288824
50PNCK1.06251285
51ICK1.04790456
52SCYL21.04686746
53CAMK1D1.02166687
54ACVR1B1.01804301
55PAK41.01613729
56MET0.96950738
57PIM10.96483409
58MAP4K10.96215573
59CDK80.96076887
60CDK20.95566851
61NME20.95417414
62MTOR0.95298403
63ALK0.94471420
64EIF2AK20.93456881
65LRRK20.89611561
66MKNK20.87272022
67DYRK30.85259710
68TTN0.84388770
69AURKA0.78077299
70CDK10.76685479
71IRAK30.72369348
72TSSK60.71253429
73TAOK10.64937295
74PAK20.64001130
75CDK90.62582193
76CCNB10.61205478
77PTK60.57577388
78TGFBR10.55985161
79PDGFRB0.55243776
80TRIM280.54243673
81PDGFRA0.51979185
82EPHA20.51568289
83CSF1R0.50309475
84TRPM70.50011405
85MARK30.49215806
86BMX0.48706508
87TLK10.47079919
88CLK10.46911932
89CAMK1G0.46502230
90PAK10.46330044
91DMPK0.45152562
92MAPK140.44607859
93JAK30.44563357
94AKT20.44298180
95CSNK1D0.44172662
96MAP3K90.43937214
97CDK180.42967419
98CDK150.42134144
99CDK11A0.41685621
100FLT30.40945785
101PRKDC0.40252803
102MAPK110.39646245
103VRK10.38602310
104PTK20.38060991
105NEK90.37843014
106GRK60.37113584
107MAP2K30.36898203
108NUAK10.36704876
109AKT10.35473946
110PRKCI0.35059298
111CDK140.34572730
112SIK20.32697438
113CSNK2A10.32318774
114PRPF4B0.31376070
115MAP3K60.31215629
116CSNK2A20.30364847
117CHUK0.30110559
118MAPKAPK20.30106938
119CSNK1E0.29791348
120TESK10.29142333
121FGFR10.29092479
122EIF2AK30.29038706
123MAPK10.28822080
124KSR10.27733966
125RAF10.26980347
126GSK3B0.26553845
127YES10.21816731

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.92009476
2Cell cycle_Homo sapiens_hsa041103.37473895
3Mismatch repair_Homo sapiens_hsa034303.21503996
4RNA transport_Homo sapiens_hsa030132.81164537
5Spliceosome_Homo sapiens_hsa030402.62496056
6Homologous recombination_Homo sapiens_hsa034402.51444888
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50778354
8Base excision repair_Homo sapiens_hsa034102.39409880
9Fanconi anemia pathway_Homo sapiens_hsa034602.28091106
10p53 signaling pathway_Homo sapiens_hsa041152.11528403
11One carbon pool by folate_Homo sapiens_hsa006702.06007189
12Nucleotide excision repair_Homo sapiens_hsa034202.03294927
13Non-homologous end-joining_Homo sapiens_hsa034501.96770666
14mRNA surveillance pathway_Homo sapiens_hsa030151.96588905
15MicroRNAs in cancer_Homo sapiens_hsa052061.67813901
16RNA degradation_Homo sapiens_hsa030181.64175281
17Proteasome_Homo sapiens_hsa030501.62783213
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53562397
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50386362
20Chronic myeloid leukemia_Homo sapiens_hsa052201.48504592
21Small cell lung cancer_Homo sapiens_hsa052221.48128756
22Viral carcinogenesis_Homo sapiens_hsa052031.47286197
23Basal transcription factors_Homo sapiens_hsa030221.46975648
24Biosynthesis of amino acids_Homo sapiens_hsa012301.38558745
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36721127
26Herpes simplex infection_Homo sapiens_hsa051681.30660329
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23854449
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.23040226
29RNA polymerase_Homo sapiens_hsa030201.22329633
30Systemic lupus erythematosus_Homo sapiens_hsa053221.21539195
31HTLV-I infection_Homo sapiens_hsa051661.21091232
32Epstein-Barr virus infection_Homo sapiens_hsa051691.17137088
33Pancreatic cancer_Homo sapiens_hsa052121.16231266
34Colorectal cancer_Homo sapiens_hsa052101.15434465
35Oocyte meiosis_Homo sapiens_hsa041141.15154009
36Pyrimidine metabolism_Homo sapiens_hsa002401.12839499
37Lysine degradation_Homo sapiens_hsa003101.11144169
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09928990
39Hepatitis B_Homo sapiens_hsa051611.06054015
40Antigen processing and presentation_Homo sapiens_hsa046121.05834082
41Non-small cell lung cancer_Homo sapiens_hsa052231.03551205
42mTOR signaling pathway_Homo sapiens_hsa041501.02514597
43Viral myocarditis_Homo sapiens_hsa054161.01125728
44Thyroid cancer_Homo sapiens_hsa052160.99964608
45Adherens junction_Homo sapiens_hsa045200.99649396
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97266880
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95003095
48Vitamin B6 metabolism_Homo sapiens_hsa007500.92933835
49Carbon metabolism_Homo sapiens_hsa012000.92750556
50Pyruvate metabolism_Homo sapiens_hsa006200.92726628
51Apoptosis_Homo sapiens_hsa042100.92610436
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92447860
53Prostate cancer_Homo sapiens_hsa052150.92386392
54B cell receptor signaling pathway_Homo sapiens_hsa046620.92005770
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91903601
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90556241
57Ribosome_Homo sapiens_hsa030100.88442935
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87024477
59Bladder cancer_Homo sapiens_hsa052190.86503563
60TGF-beta signaling pathway_Homo sapiens_hsa043500.84349401
61Notch signaling pathway_Homo sapiens_hsa043300.84119428
62Primary immunodeficiency_Homo sapiens_hsa053400.81344550
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.81278850
64Shigellosis_Homo sapiens_hsa051310.80924196
65Pentose phosphate pathway_Homo sapiens_hsa000300.80459832
66Hippo signaling pathway_Homo sapiens_hsa043900.80438099
67Proteoglycans in cancer_Homo sapiens_hsa052050.80314187
68Measles_Homo sapiens_hsa051620.76846029
69Endometrial cancer_Homo sapiens_hsa052130.76753591
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75572944
71Acute myeloid leukemia_Homo sapiens_hsa052210.74738243
72Leishmaniasis_Homo sapiens_hsa051400.73537488
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.72591168
74N-Glycan biosynthesis_Homo sapiens_hsa005100.72056648
75FoxO signaling pathway_Homo sapiens_hsa040680.70609409
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69301205
77Steroid biosynthesis_Homo sapiens_hsa001000.67893202
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66643084
79Basal cell carcinoma_Homo sapiens_hsa052170.66285150
80Pathways in cancer_Homo sapiens_hsa052000.65863558
81Influenza A_Homo sapiens_hsa051640.65415146
82Folate biosynthesis_Homo sapiens_hsa007900.65396218
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64908166
84Protein export_Homo sapiens_hsa030600.62902713
85Glioma_Homo sapiens_hsa052140.62646133
86Legionellosis_Homo sapiens_hsa051340.61859636
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.61458693
88Renal cell carcinoma_Homo sapiens_hsa052110.60745443
89HIF-1 signaling pathway_Homo sapiens_hsa040660.60681523
90Toxoplasmosis_Homo sapiens_hsa051450.59576890
91Melanoma_Homo sapiens_hsa052180.59561128
92Hematopoietic cell lineage_Homo sapiens_hsa046400.58350077
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.57774920
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57308528
95Wnt signaling pathway_Homo sapiens_hsa043100.56963571
96Osteoclast differentiation_Homo sapiens_hsa043800.55497546
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55364742
98VEGF signaling pathway_Homo sapiens_hsa043700.54635942
99Focal adhesion_Homo sapiens_hsa045100.53050921
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52326834
101Prolactin signaling pathway_Homo sapiens_hsa049170.50169653
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.47682071
103Platelet activation_Homo sapiens_hsa046110.46559784
104T cell receptor signaling pathway_Homo sapiens_hsa046600.46381516
105TNF signaling pathway_Homo sapiens_hsa046680.43724517
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43211146
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.42842879
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41883904
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40656231
110Purine metabolism_Homo sapiens_hsa002300.39844429
111Hedgehog signaling pathway_Homo sapiens_hsa043400.38353004
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38214466
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38162936
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37931061
115Tuberculosis_Homo sapiens_hsa051520.37852549
116Alcoholism_Homo sapiens_hsa050340.37008972
117Selenocompound metabolism_Homo sapiens_hsa004500.36784636
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36490447
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36064866
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35794483
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35718312
122Sulfur relay system_Homo sapiens_hsa041220.32507447
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31723479
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30454339
125ErbB signaling pathway_Homo sapiens_hsa040120.28783259
126Tight junction_Homo sapiens_hsa045300.27701948
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26655795
128Glutathione metabolism_Homo sapiens_hsa004800.25921267
129Fructose and mannose metabolism_Homo sapiens_hsa000510.25704086
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24423885
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24388874
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24357996
133Galactose metabolism_Homo sapiens_hsa000520.20730772
134AMPK signaling pathway_Homo sapiens_hsa041520.19852897

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