ARFIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.97535232
2Golgi transport vesicle coating (GO:0048200)5.97535232
3GDP-mannose metabolic process (GO:0019673)5.56633325
4synaptic vesicle maturation (GO:0016188)5.40744997
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27308536
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.06936099
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.02815013
8protein retention in ER lumen (GO:0006621)5.00937035
9axonemal dynein complex assembly (GO:0070286)4.91056733
10locomotory exploration behavior (GO:0035641)4.49983965
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.49207324
12mitotic nuclear envelope reassembly (GO:0007084)4.20883317
13nuclear envelope reassembly (GO:0031468)4.20883317
14sodium ion export (GO:0071436)4.19137882
15proline biosynthetic process (GO:0006561)4.16315024
16peptidyl-arginine omega-N-methylation (GO:0035247)4.14963378
17synaptic vesicle exocytosis (GO:0016079)4.13391247
18glutamate secretion (GO:0014047)4.11159056
19retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.10890082
20layer formation in cerebral cortex (GO:0021819)4.01109323
21cellular potassium ion homeostasis (GO:0030007)3.96428165
22regulation of synaptic vesicle exocytosis (GO:2000300)3.92982921
23activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.89703674
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.87035089
25regulation of mitochondrial translation (GO:0070129)3.86355368
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.85701490
27cerebellar Purkinje cell layer development (GO:0021680)3.73357467
28response to pheromone (GO:0019236)3.73287580
29activation of protein kinase A activity (GO:0034199)3.72057361
30lipopolysaccharide biosynthetic process (GO:0009103)3.72005128
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.71637802
32positive regulation of nuclease activity (GO:0032075)3.71530186
33histone arginine methylation (GO:0034969)3.60895317
34cell communication by electrical coupling (GO:0010644)3.58993241
35desmosome organization (GO:0002934)3.54568673
36motile cilium assembly (GO:0044458)3.52003082
37neurotransmitter secretion (GO:0007269)3.43890450
38positive regulation of synapse maturation (GO:0090129)3.40029075
39regulation of synaptic vesicle transport (GO:1902803)3.32782621
40regulation of synapse structural plasticity (GO:0051823)3.29374563
41regulation of nuclease activity (GO:0032069)3.29234845
42membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.29128270
43regulation of clathrin-mediated endocytosis (GO:2000369)3.27620839
44peptidyl-arginine methylation (GO:0018216)3.27297682
45peptidyl-arginine N-methylation (GO:0035246)3.27297682
46exploration behavior (GO:0035640)3.23033880
47exocrine pancreas development (GO:0031017)3.22660235
48potassium ion homeostasis (GO:0055075)3.22525318
49establishment of apical/basal cell polarity (GO:0035089)3.22447918
50spliceosomal tri-snRNP complex assembly (GO:0000244)3.21548862
51vesicle coating (GO:0006901)3.21467109
52growth hormone secretion (GO:0030252)3.19445230
53cytoskeletal anchoring at plasma membrane (GO:0007016)3.18598945
54proline transport (GO:0015824)3.16687910
55protein maturation by protein folding (GO:0022417)3.15098521
56cilium or flagellum-dependent cell motility (GO:0001539)3.13281472
57neuromuscular process controlling posture (GO:0050884)3.11981313
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.11799709
59endoplasmic reticulum unfolded protein response (GO:0030968)3.11728822
60proline metabolic process (GO:0006560)3.09713636
61regulation of glutamate receptor signaling pathway (GO:1900449)3.09652522
62COPII vesicle coating (GO:0048208)3.07489802
63innervation (GO:0060384)3.06864183
64negative regulation of DNA-templated transcription, elongation (GO:0032785)3.06616163
65chemosensory behavior (GO:0007635)3.06608813
66vocalization behavior (GO:0071625)3.05522694
67nucleotide-sugar biosynthetic process (GO:0009226)3.05378236
68amyloid precursor protein catabolic process (GO:0042987)3.05316649
69membrane repolarization (GO:0086009)3.01055592
70regulation of neuronal synaptic plasticity (GO:0048168)2.99516716
71membrane repolarization during action potential (GO:0086011)2.98073421
72cellular response to unfolded protein (GO:0034620)2.97511853
73negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.94493886
74negative regulation of microtubule polymerization (GO:0031115)2.94080357
75protein localization to synapse (GO:0035418)2.93238165
76peptidyl-histidine modification (GO:0018202)2.91301208
77negative regulation of T cell differentiation in thymus (GO:0033085)2.89666790
78UV protection (GO:0009650)2.88039120
79regulation of ARF protein signal transduction (GO:0032012)2.87688413
80protein insertion into membrane (GO:0051205)2.87545491
81dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.87399874
82cellular response to topologically incorrect protein (GO:0035967)2.87321628
83primary alcohol catabolic process (GO:0034310)2.86652407
84cellular sodium ion homeostasis (GO:0006883)2.86132998
85ER-nucleus signaling pathway (GO:0006984)2.85985637
86ribosome biogenesis (GO:0042254)2.84401621
87regulation of calcium ion-dependent exocytosis (GO:0017158)2.83139728
88regulation of translational fidelity (GO:0006450)2.80830012
89left/right pattern formation (GO:0060972)2.80504168
90dendritic spine organization (GO:0097061)2.80263597
91regulation of synapse maturation (GO:0090128)2.80144004
92lung epithelium development (GO:0060428)2.77524963
93positive regulation of membrane potential (GO:0045838)2.76476495
94cilium movement (GO:0003341)2.75517460
95regulation of translational termination (GO:0006449)2.74531429
96regulation of long-term neuronal synaptic plasticity (GO:0048169)2.74367593
97neuromuscular process controlling balance (GO:0050885)2.72735513
98ER overload response (GO:0006983)2.72676497
99suckling behavior (GO:0001967)2.72269443
100dendritic spine morphogenesis (GO:0060997)2.71360740
101long-term memory (GO:0007616)2.70943391
102negative regulation of cell size (GO:0045792)2.70629081
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69796548
104metallo-sulfur cluster assembly (GO:0031163)2.69246577
105iron-sulfur cluster assembly (GO:0016226)2.69246577
106response to parathyroid hormone (GO:0071107)2.68879874
107establishment or maintenance of monopolar cell polarity (GO:0061339)2.66540432
108establishment of monopolar cell polarity (GO:0061162)2.66540432
109snRNA metabolic process (GO:0016073)2.66100443
110ubiquinone biosynthetic process (GO:0006744)2.65923306
111peptidyl-proline hydroxylation (GO:0019511)2.65759143
112maternal placenta development (GO:0001893)2.64583166
113mannosylation (GO:0097502)2.64445523
114guanosine-containing compound biosynthetic process (GO:1901070)2.63147062
115neurotransmitter transport (GO:0006836)2.62055925
116regulation of early endosome to late endosome transport (GO:2000641)2.61711960
117regulation of mammary gland epithelial cell proliferation (GO:0033599)2.61549234
118base-excision repair, AP site formation (GO:0006285)2.61388142
119establishment of viral latency (GO:0019043)2.61014699
120virion assembly (GO:0019068)2.60416459
121neuronal action potential propagation (GO:0019227)2.59552850
122ribosomal small subunit biogenesis (GO:0042274)2.59417240
123glycine transport (GO:0015816)2.58699323
124vesicle transport along microtubule (GO:0047496)2.58662320
125negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.58330594
126UTP biosynthetic process (GO:0006228)2.57963709
127ribonucleoprotein complex biogenesis (GO:0022613)2.57714620
128positive regulation of vesicle fusion (GO:0031340)2.57262151
129dopamine receptor signaling pathway (GO:0007212)2.56777697
130L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56465400
131dendrite morphogenesis (GO:0048813)2.54344174
132positive regulation of exocytosis (GO:0045921)2.54016606
133snRNA processing (GO:0016180)2.53104344
134cellular response to glucagon stimulus (GO:0071377)2.51956351
135response to endoplasmic reticulum stress (GO:0034976)2.50659699
136potassium ion import (GO:0010107)2.50434459
137negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.50235845
138N-glycan processing (GO:0006491)2.49525653
139vitamin transmembrane transport (GO:0035461)2.49476847
140cellular zinc ion homeostasis (GO:0006882)2.49336447
141glutathione biosynthetic process (GO:0006750)2.49329329
142cerebellar Purkinje cell differentiation (GO:0021702)2.48513121
143axoneme assembly (GO:0035082)2.47969675
144alanine transport (GO:0032328)2.47846217
145insulin secretion (GO:0030073)2.47511984
146regulation of cholesterol biosynthetic process (GO:0045540)2.46814863
147adenosine receptor signaling pathway (GO:0001973)2.46721210
148synaptic transmission, glutamatergic (GO:0035249)2.45086275
149establishment of integrated proviral latency (GO:0075713)2.44969514
150peptidyl-lysine dimethylation (GO:0018027)2.44803583
151regulation of synaptic plasticity (GO:0048167)2.44625110
152positive regulation of protein targeting to membrane (GO:0090314)2.44132982
153lipopolysaccharide metabolic process (GO:0008653)2.43604020
154organelle transport along microtubule (GO:0072384)2.43202719
155axon cargo transport (GO:0008088)2.42401094
156positive regulation of guanylate cyclase activity (GO:0031284)2.41954674
157erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.40677160
158L-phenylalanine metabolic process (GO:0006558)2.40677160
159nonribosomal peptide biosynthetic process (GO:0019184)2.40283111
160glial cell proliferation (GO:0014009)2.40133687
161tRNA methylation (GO:0030488)2.39659437
162positive regulation of neurotransmitter transport (GO:0051590)2.39615966
163glutamine family amino acid biosynthetic process (GO:0009084)2.39375475
164positive regulation of synaptic transmission, GABAergic (GO:0032230)2.39375144
165signal release (GO:0023061)2.38935865
166pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.38893225
167negative regulation of glycogen biosynthetic process (GO:0045719)2.38383132
168regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.37868804
169respiratory tube development (GO:0030323)2.37642245
170regulation of vesicle fusion (GO:0031338)2.37480948
171epithelial cilium movement (GO:0003351)2.37151429
172quinone biosynthetic process (GO:1901663)2.36698094
173GTP biosynthetic process (GO:0006183)2.36559549
174zinc ion transmembrane transport (GO:0071577)2.35853383
175type B pancreatic cell proliferation (GO:0044342)2.35364863
176ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.34424628
177ubiquinone metabolic process (GO:0006743)2.33739663
178regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.33356777
179UTP metabolic process (GO:0046051)2.32768557
180urea cycle (GO:0000050)2.31620824
181NADH metabolic process (GO:0006734)2.28482640
182ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.27669894
183diterpenoid biosynthetic process (GO:0016102)2.26777564
184nucleobase-containing small molecule interconversion (GO:0015949)2.26256904
1854-hydroxyproline metabolic process (GO:0019471)2.25582073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.23554084
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01091577
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.98066934
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.79471265
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.74931767
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.61615681
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60007383
8ZFP281_18757296_ChIP-ChIP_E14_Mouse2.58308361
9DROSHA_22980978_ChIP-Seq_HELA_Human2.42032453
10ERG_21242973_ChIP-ChIP_JURKAT_Human2.41636984
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41491687
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.30155121
13XRN2_22483619_ChIP-Seq_HELA_Human2.28692506
14* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.26066168
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.23109693
16LXR_22292898_ChIP-Seq_THP-1_Human2.22397649
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.19309093
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19021700
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18267119
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15396787
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.06032846
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05576849
23KDM2B_26808549_Chip-Seq_K562_Human2.03524044
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.00264148
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99186637
26EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.99033297
27REST_21632747_ChIP-Seq_MESCs_Mouse1.98533870
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96831702
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.92567188
30GABP_19822575_ChIP-Seq_HepG2_Human1.91707333
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.91160321
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.89194908
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88786137
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88427385
35DCP1A_22483619_ChIP-Seq_HELA_Human1.87490745
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86594229
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83705818
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82986416
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82986416
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.82280570
41SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80031273
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79329403
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79256561
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.79040937
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78631397
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.78346814
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70396670
48TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69027600
49KDM5A_27292631_Chip-Seq_BREAST_Human1.68742954
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68029895
51CREB1_26743006_Chip-Seq_LNCaP_Human1.66163454
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66130310
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.65986541
54* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.65133760
55* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65107419
56KDM2B_26808549_Chip-Seq_DND41_Human1.63517224
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63072472
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61988202
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58999649
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.58975547
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.58913308
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58025317
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57485458
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56657532
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56379590
66MYC_22102868_ChIP-Seq_BL_Human1.55123005
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54821184
68* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53825434
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52862799
70RACK7_27058665_Chip-Seq_MCF-7_Human1.52170560
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51248984
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50294618
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.49068003
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48816799
75* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48167923
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48070486
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.47647095
78TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.47343023
79SMC4_20622854_ChIP-Seq_HELA_Human1.46915292
80ZNF274_21170338_ChIP-Seq_K562_Hela1.46582317
81* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46164208
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45595142
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.44717355
84ZNF263_19887448_ChIP-Seq_K562_Human1.44142493
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43823409
86TTF2_22483619_ChIP-Seq_HELA_Human1.43618919
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43500318
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43425459
89CLOCK_20551151_ChIP-Seq_293T_Human1.41817597
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41258264
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40973935
92TET1_21490601_ChIP-Seq_MESCs_Mouse1.40768501
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40242514
94FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38549885
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.38171915
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37159135
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34572180
98P68_20966046_ChIP-Seq_HELA_Human1.34205114
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33955327
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33146492
101VDR_21846776_ChIP-Seq_THP-1_Human1.33071465
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32779442
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32754609
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29925693
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29576550
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28738902
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.28115461
108EZH2_27304074_Chip-Seq_ESCs_Mouse1.28047236
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27610545
110STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27589001
111CTCF_27219007_Chip-Seq_Bcells_Human1.27068414
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26205362
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.24206521
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24035439
115ESR1_21235772_ChIP-Seq_MCF-7_Human1.21788545
116EED_16625203_ChIP-ChIP_MESCs_Mouse1.21690716
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20179278
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19904877
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.19716540
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19508830
121MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19064030
122TP53_22127205_ChIP-Seq_IMR90_Human1.19020796
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18599159
124RING1B_27294783_Chip-Seq_ESCs_Mouse1.18066077
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17495743
126* ELK3_25401928_ChIP-Seq_HUVEC_Human1.17042283
127* RARB_24833708_ChIP-Seq_LIVER_Mouse1.16063022
128POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16037362
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15997127
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15079205
131TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.15035582
132EST1_17652178_ChIP-ChIP_JURKAT_Human1.14980493
133* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14173025
134KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13928576
135CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12971929
136BCOR_27268052_Chip-Seq_Bcells_Human1.12386513
137WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12301813
138PHF8_20622854_ChIP-Seq_HELA_Human1.12280399
139NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12219230
140TBX5_21415370_ChIP-Seq_HL-1_Mouse1.11842291
141ATF3_27146783_Chip-Seq_COLON_Human1.10400720
142FOXP1_21924763_ChIP-Seq_HESCs_Human1.10364613
143SA1_27219007_Chip-Seq_ERYTHROID_Human1.09976805
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.09938242
145TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09551852
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07817181
147THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06882138
148ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06715293
149BCL6_27268052_Chip-Seq_Bcells_Human1.05296783
150TET1_21451524_ChIP-Seq_MESCs_Mouse1.04976395
151RARA_24833708_ChIP-Seq_LIVER_Mouse1.04648262
152ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03969051
153CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02909205
154RUNX1_27514584_Chip-Seq_MCF-7_Human1.00956710
155AR_19668381_ChIP-Seq_PC3_Human1.00861326
156TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00696574
157CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00552199
158SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00413686
159FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00204051
160TP63_22573176_ChIP-Seq_HFKS_Human0.99815196
161TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97457104
162PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96075563
163ELF1_20517297_ChIP-Seq_JURKAT_Human0.95524058
164ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95436832
165TP53_23651856_ChIP-Seq_MEFs_Mouse0.95154982
166RING1B_27294783_Chip-Seq_NPCs_Mouse0.94660019
167E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92861168
168SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91682163
169CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91467240
170FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90416197
171MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89511012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.20677843
2MP0002909_abnormal_adrenal_gland3.31588239
3MP0003283_abnormal_digestive_organ2.99326794
4MP0009780_abnormal_chondrocyte_physiolo2.95068970
5MP0003635_abnormal_synaptic_transmissio2.86572071
6MP0003693_abnormal_embryo_hatching2.82246832
7MP0008875_abnormal_xenobiotic_pharmacok2.73156197
8MP0000013_abnormal_adipose_tissue2.71306901
9MP0009840_abnormal_foam_cell2.62870121
10MP0010234_abnormal_vibrissa_follicle2.55584927
11MP0004270_analgesia2.45987322
12MP0010030_abnormal_orbit_morphology2.39940331
13MP0002796_impaired_skin_barrier2.35658618
14MP0005501_abnormal_skin_physiology2.32434059
15MP0003122_maternal_imprinting2.21217185
16MP0004858_abnormal_nervous_system2.19795443
17MP0002063_abnormal_learning/memory/cond2.10105335
18MP0000003_abnormal_adipose_tissue2.07224962
19MP0000537_abnormal_urethra_morphology2.02866824
20MP0003191_abnormal_cellular_cholesterol1.97245620
21MP0005058_abnormal_lysosome_morphology1.93502402
22MP0005220_abnormal_exocrine_pancreas1.93142824
23MP0004233_abnormal_muscle_weight1.92692423
24MP0002734_abnormal_mechanical_nocicepti1.86051397
25MP0004043_abnormal_pH_regulation1.84922518
26MP0002064_seizures1.80118963
27MP0004782_abnormal_surfactant_physiolog1.78328349
28MP0003786_premature_aging1.72915603
29MP0001346_abnormal_lacrimal_gland1.71386853
30MP0008961_abnormal_basal_metabolism1.69047867
31MP0009745_abnormal_behavioral_response1.68634682
32MP0003329_amyloid_beta_deposits1.67423314
33MP0001968_abnormal_touch/_nociception1.66133102
34MP0010386_abnormal_urinary_bladder1.66028283
35MP0003123_paternal_imprinting1.64340335
36MP0001944_abnormal_pancreas_morphology1.62525548
37MP0003111_abnormal_nucleus_morphology1.60405858
38MP0004811_abnormal_neuron_physiology1.56998028
39MP0002572_abnormal_emotion/affect_behav1.56375834
40MP0006072_abnormal_retinal_apoptosis1.53934289
41MP0002098_abnormal_vibrissa_morphology1.51642689
42MP0004185_abnormal_adipocyte_glucose1.47566500
43MP0003183_abnormal_peptide_metabolism1.45407350
44MP0000467_abnormal_esophagus_morphology1.43805723
45MP0000955_abnormal_spinal_cord1.42297021
46MP0003705_abnormal_hypodermis_morpholog1.42295028
47MP0002184_abnormal_innervation1.41922057
48MP0003880_abnormal_central_pattern1.41080801
49MP0004957_abnormal_blastocyst_morpholog1.41072187
50MP0002272_abnormal_nervous_system1.40017413
51MP0002060_abnormal_skin_morphology1.39415970
52MP0005451_abnormal_body_composition1.38243691
53MP0001727_abnormal_embryo_implantation1.35841530
54MP0003453_abnormal_keratinocyte_physiol1.35672537
55MP0009046_muscle_twitch1.35166640
56MP0002089_abnormal_postnatal_growth/wei1.32417070
57MP0008932_abnormal_embryonic_tissue1.31242586
58MP0000534_abnormal_ureter_morphology1.29973497
59MP0009384_cardiac_valve_regurgitation1.29246557
60MP0003941_abnormal_skin_development1.28969299
61MP0002160_abnormal_reproductive_system1.28419949
62MP0002693_abnormal_pancreas_physiology1.28286566
63MP0004885_abnormal_endolymph1.28161242
64MP0001970_abnormal_pain_threshold1.26677023
65MP0000762_abnormal_tongue_morphology1.26376013
66MP0003566_abnormal_cell_adhesion1.26298526
67MP0001216_abnormal_epidermal_layer1.26076835
68MP0008007_abnormal_cellular_replicative1.25929982
69MP0001881_abnormal_mammary_gland1.25792982
70MP0010678_abnormal_skin_adnexa1.25663563
71MP0005360_urolithiasis1.24556724
72MP0003119_abnormal_digestive_system1.24547841
73MP0000579_abnormal_nail_morphology1.24455140
74MP0008058_abnormal_DNA_repair1.24045233
75MP0005083_abnormal_biliary_tract1.21585488
76MP0002896_abnormal_bone_mineralization1.20344525
77MP0002733_abnormal_thermal_nociception1.20168717
78MP0010771_integument_phenotype1.19829764
79MP0000678_abnormal_parathyroid_gland1.19762260
80MP0003879_abnormal_hair_cell1.19324446
81MP0005423_abnormal_somatic_nervous1.19158135
82MP0002557_abnormal_social/conspecific_i1.17709352
83MP0000462_abnormal_digestive_system1.17101886
84MP0000358_abnormal_cell_content/1.15378878
85MP0001486_abnormal_startle_reflex1.13033272
86MP0008569_lethality_at_weaning1.11376559
87MP0002234_abnormal_pharynx_morphology1.11220651
88MP0001664_abnormal_digestion1.11035833
89MP0005645_abnormal_hypothalamus_physiol1.10981982
90MP0002882_abnormal_neuron_morphology1.10832569
91MP0001661_extended_life_span1.08943497
92MP0000627_abnormal_mammary_gland1.08623408
93MP0000566_synostosis1.07231039
94MP0003787_abnormal_imprinting1.06673988
95MP0003077_abnormal_cell_cycle1.05468429
96MP0001440_abnormal_grooming_behavior1.02869905
97MP0002736_abnormal_nociception_after1.02414124
98MP0008438_abnormal_cutaneous_collagen1.02331024
99MP0001501_abnormal_sleep_pattern1.01666684
100MP0000681_abnormal_thyroid_gland1.00480578
101MP0001765_abnormal_ion_homeostasis0.99877250
102MP0002067_abnormal_sensory_capabilities0.99332143
103MP0000377_abnormal_hair_follicle0.99159180
104MP0005084_abnormal_gallbladder_morpholo0.98163038
105MP0003718_maternal_effect0.97959013
106MP0004272_abnormal_basement_membrane0.97643731
107MP0005623_abnormal_meninges_morphology0.97511189
108MP0005187_abnormal_penis_morphology0.97230591
109MP0008789_abnormal_olfactory_epithelium0.97175625
110MP0001666_abnormal_nutrient_absorption0.96769061
111MP0002877_abnormal_melanocyte_morpholog0.96155264
112MP0002080_prenatal_lethality0.95433751
113MP0002066_abnormal_motor_capabilities/c0.94902075
114MP0008260_abnormal_autophagy0.94285113
115MP0005386_behavior/neurological_phenoty0.94067047
116MP0004924_abnormal_behavior0.94067047
117MP0001299_abnormal_eye_distance/0.93486773
118MP0002653_abnormal_ependyma_morphology0.93022983
119MP0004133_heterotaxia0.92688918
120MP0005551_abnormal_eye_electrophysiolog0.91411425
121MP0002876_abnormal_thyroid_physiology0.90358610
122MP0000778_abnormal_nervous_system0.89890719
123MP0004147_increased_porphyrin_level0.89877791
124MP0003959_abnormal_lean_body0.89458672
125MP0000751_myopathy0.89308981
126MP0002069_abnormal_eating/drinking_beha0.88567741
127MP0002822_catalepsy0.88487496
128MP0001188_hyperpigmentation0.87762604
129MP0002152_abnormal_brain_morphology0.87758153
130MP0003186_abnormal_redox_activity0.87669829
131MP0001502_abnormal_circadian_rhythm0.87404198
132MP0001243_abnormal_dermal_layer0.87313411
133MP0005257_abnormal_intraocular_pressure0.86810074
134MP0006036_abnormal_mitochondrial_physio0.85452972
135MP0002282_abnormal_trachea_morphology0.85449699
136MP0004019_abnormal_vitamin_homeostasis0.84278965
137MP0005076_abnormal_cell_differentiation0.84190200
138MP0002735_abnormal_chemical_nociception0.84081204
139MP0001873_stomach_inflammation0.83369976
140MP0005375_adipose_tissue_phenotype0.83012358
141MP0001984_abnormal_olfaction0.82980620
142MP0001756_abnormal_urination0.82642579
143MP0000747_muscle_weakness0.82554976
144MP0009643_abnormal_urine_homeostasis0.82402882
145MP0005636_abnormal_mineral_homeostasis0.82096078
146MP0005275_abnormal_skin_tensile0.80570318
147MP0002078_abnormal_glucose_homeostasis0.80497823
148MP0003045_fibrosis0.80383962
149MP0004264_abnormal_extraembryonic_tissu0.80193155
150MP0001905_abnormal_dopamine_level0.80075394
151MP0000350_abnormal_cell_proliferation0.79507836
152MP0000631_abnormal_neuroendocrine_gland0.79230610
153MP0003634_abnormal_glial_cell0.78379241
154MP0000490_abnormal_crypts_of0.78328877
155MP0009672_abnormal_birth_weight0.78292347
156MP0003942_abnormal_urinary_system0.78163337
157MP0006035_abnormal_mitochondrial_morpho0.75323617
158MP0003121_genomic_imprinting0.75057744
159MP0005394_taste/olfaction_phenotype0.74928588
160MP0005499_abnormal_olfactory_system0.74928588
161MP0005384_cellular_phenotype0.74338950
162MP0002111_abnormal_tail_morphology0.74160538
163MP0005165_increased_susceptibility_to0.73582050
164MP0002249_abnormal_larynx_morphology0.72979525
165MP0003953_abnormal_hormone_level0.72341054
166MP0000477_abnormal_intestine_morphology0.72275094
167MP0001348_abnormal_lacrimal_gland0.72248863
168MP0005621_abnormal_cell_physiology0.72038325
169MP0001849_ear_inflammation0.71963999

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.00786915
2Myokymia (HP:0002411)4.50976647
3Abnormal respiratory epithelium morphology (HP:0012253)4.02877781
4Abnormal respiratory motile cilium morphology (HP:0005938)4.02877781
5Chronic bronchitis (HP:0004469)3.67916697
6Rhinitis (HP:0012384)3.65738792
7Abnormal respiratory motile cilium physiology (HP:0012261)3.64666720
8Abnormality of the distal phalanges of the toes (HP:0010182)3.51319344
9Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.45072968
10Visual hallucinations (HP:0002367)3.44680414
11Action tremor (HP:0002345)3.21849561
12Testicular atrophy (HP:0000029)3.18463807
13Abnormal ciliary motility (HP:0012262)3.09915894
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.06797428
15Absent/shortened dynein arms (HP:0200106)3.06797428
16Short nail (HP:0001799)2.88434585
17Microretrognathia (HP:0000308)2.83671177
18Stridor (HP:0010307)2.81431465
19Ankle clonus (HP:0011448)2.79219636
20Abnormal protein glycosylation (HP:0012346)2.77465924
21Abnormal glycosylation (HP:0012345)2.77465924
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.77465924
23Abnormal protein N-linked glycosylation (HP:0012347)2.77465924
24Focal motor seizures (HP:0011153)2.75953251
25Hypokinesia (HP:0002375)2.75090800
26Hypercortisolism (HP:0001578)2.73856911
27Supranuclear gaze palsy (HP:0000605)2.70133585
28Insomnia (HP:0100785)2.66555695
29Megalencephaly (HP:0001355)2.63814481
30Hand muscle atrophy (HP:0009130)2.62692553
31Focal seizures (HP:0007359)2.55915644
32Depression (HP:0000716)2.55473289
33Cervical subluxation (HP:0003308)2.51691450
34Atelectasis (HP:0100750)2.50789510
35Pointed chin (HP:0000307)2.50710215
36Upper limb muscle weakness (HP:0003484)2.48149153
37Upper limb amyotrophy (HP:0009129)2.45912411
38Distal upper limb amyotrophy (HP:0007149)2.45912411
39Rough bone trabeculation (HP:0100670)2.45820420
40Hyperacusis (HP:0010780)2.40481650
41Abnormality of the lower motor neuron (HP:0002366)2.40441363
42Papilledema (HP:0001085)2.40064426
43Progressive cerebellar ataxia (HP:0002073)2.39090948
44Agitation (HP:0000713)2.38465656
45Ankyloglossia (HP:0010296)2.38326628
46Ventricular fibrillation (HP:0001663)2.36198059
47Premature rupture of membranes (HP:0001788)2.35727950
48Abnormality of dentin (HP:0010299)2.34726917
49Shallow orbits (HP:0000586)2.34213003
50Hypoventilation (HP:0002791)2.34159547
51Hepatocellular necrosis (HP:0001404)2.33028338
52Abnormality of the umbilical cord (HP:0010881)2.32251300
53Long toe (HP:0010511)2.31553947
54Flattened epiphyses (HP:0003071)2.31146763
55Hypoplasia of the capital femoral epiphysis (HP:0003090)2.30628771
56Type I transferrin isoform profile (HP:0003642)2.30399971
57Nasal polyposis (HP:0100582)2.30365906
58Infertility (HP:0000789)2.30066156
59Sparse lateral eyebrow (HP:0005338)2.26344750
60Bronchiectasis (HP:0002110)2.25156759
61Achilles tendon contracture (HP:0001771)2.23790663
62Congenital glaucoma (HP:0001087)2.21437928
63Cerebral aneurysm (HP:0004944)2.19806277
64Hemiplegia (HP:0002301)2.19749916
65Genetic anticipation (HP:0003743)2.19062546
66Gout (HP:0001997)2.16506710
67Abnormality of aromatic amino acid family metabolism (HP:0004338)2.15302784
68Anxiety (HP:0000739)2.13896286
69Vertebral compression fractures (HP:0002953)2.13045998
70Enlarged penis (HP:0000040)2.12722512
71Male infertility (HP:0003251)2.12063551
72EEG with generalized epileptiform discharges (HP:0011198)2.11638791
73Abnormal umbilical cord blood vessels (HP:0011403)2.11556561
74Single umbilical artery (HP:0001195)2.11556561
75Abnormality of the fetal cardiovascular system (HP:0010948)2.11556561
76Impaired smooth pursuit (HP:0007772)2.09572590
77Menstrual irregularities (HP:0000858)2.08412541
78Macroorchidism (HP:0000053)2.07702699
79Hypsarrhythmia (HP:0002521)2.07677386
80Neoplasm of the heart (HP:0100544)2.05316185
81Bronchomalacia (HP:0002780)2.04802195
82Hyperparathyroidism (HP:0000843)2.04541405
83Epileptiform EEG discharges (HP:0011182)2.04291986
84Death in infancy (HP:0001522)2.03987718
85Torticollis (HP:0000473)2.03391222
86Postural tremor (HP:0002174)2.03366444
87Abnormality of oral frenula (HP:0000190)2.03148126
88Epileptic encephalopathy (HP:0200134)2.01296333
89Down-sloping shoulders (HP:0200021)2.00963460
90Absence seizures (HP:0002121)2.00535924
91Elfin facies (HP:0004428)2.00301133
92Progressive muscle weakness (HP:0003323)2.00147741
93Bowel diverticulosis (HP:0005222)1.99779853
94Abnormal trabecular bone morphology (HP:0100671)1.99264383
95Flat acetabular roof (HP:0003180)1.98734504
96Abnormality of glycolysis (HP:0004366)1.98709911
97Broad distal phalanx of finger (HP:0009836)1.98091200
98Brushfield spots (HP:0001088)1.98070062
99Entropion (HP:0000621)1.96865810
100Dysmetric saccades (HP:0000641)1.96364840
101Buphthalmos (HP:0000557)1.95869475
102Renal duplication (HP:0000075)1.95192247
103Hepatic necrosis (HP:0002605)1.95183770
104Hypoglycemic seizures (HP:0002173)1.94036969
105Long palpebral fissure (HP:0000637)1.92971677
106Abnormality of glutamine family amino acid metabolism (HP:0010902)1.92575329
107Focal dystonia (HP:0004373)1.92316206
108Postural instability (HP:0002172)1.91664401
109Testicular neoplasm (HP:0010788)1.91338482
110Dysostosis multiplex (HP:0000943)1.91120080
111Impaired vibration sensation in the lower limbs (HP:0002166)1.90171236
112Bradykinesia (HP:0002067)1.89705642
113Broad face (HP:0000283)1.89585043
114Atonic seizures (HP:0010819)1.89045338
115Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88063809
116Abnormal hair laboratory examination (HP:0003328)1.87394611
117Abnormality of calcium-phosphate metabolism (HP:0100530)1.87219820
118Spinal cord compression (HP:0002176)1.87129643
119Type II lissencephaly (HP:0007260)1.86056072
120Abnormality of the Achilles tendon (HP:0005109)1.85546963
121Reduced antithrombin III activity (HP:0001976)1.85335105
122Increased serum pyruvate (HP:0003542)1.85211565
123Turricephaly (HP:0000262)1.84204230
124Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.83636048
125Occipital encephalocele (HP:0002085)1.83164107
126Protrusio acetabuli (HP:0003179)1.82898356
127Abnormal social behavior (HP:0012433)1.82452074
128Impaired social interactions (HP:0000735)1.82452074
129Limb-girdle muscle atrophy (HP:0003797)1.81241987
130Dysdiadochokinesis (HP:0002075)1.79691139
131Growth hormone excess (HP:0000845)1.78659113
132Truncal ataxia (HP:0002078)1.77719853
133Adducted thumb (HP:0001181)1.77392241
134Craniofacial dystonia (HP:0012179)1.77304443
135Bladder diverticulum (HP:0000015)1.75667664
136Adrenal overactivity (HP:0002717)1.73423867
137Abnormality of ocular smooth pursuit (HP:0000617)1.72871760
138Short femoral neck (HP:0100864)1.72722388
139Sparse eyelashes (HP:0000653)1.72569230
140Overriding aorta (HP:0002623)1.72408564
141Hyperinsulinemic hypoglycemia (HP:0000825)1.70638371
142Abnormal eating behavior (HP:0100738)1.70548359
143Unilateral renal agenesis (HP:0000122)1.70124755
144Urinary glycosaminoglycan excretion (HP:0003541)1.68927120
145Mucopolysacchariduria (HP:0008155)1.68927120
146Aplasia/hypoplasia of the femur (HP:0005613)1.68891194
147Abnormality of the nasal mucosa (HP:0000433)1.68547028
148Prolonged neonatal jaundice (HP:0006579)1.68201078
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66954475
150Late onset (HP:0003584)1.66271678
151Angiofibromas (HP:0010615)1.66019848
152Adenoma sebaceum (HP:0009720)1.66019848
153Broad ribs (HP:0000885)1.65629602
154Squamous cell carcinoma (HP:0002860)1.65424122
155J-shaped sella turcica (HP:0002680)1.65275194
156Urinary urgency (HP:0000012)1.65059571
157Generalized tonic-clonic seizures (HP:0002069)1.64637039
158Diaphragmatic weakness (HP:0009113)1.63594238
159Abnormality of carpal bone ossification (HP:0006257)1.62451288
160Diminished movement (HP:0002374)1.62135213
161Annular pancreas (HP:0001734)1.61336128
162Septate vagina (HP:0001153)1.60918691
163Poor eye contact (HP:0000817)1.60907693
164Abnormalities of placenta or umbilical cord (HP:0001194)1.60734486
165Cerebral hypomyelination (HP:0006808)1.60116038
166Neoplasm of the peripheral nervous system (HP:0100007)1.59778480
167Elbow flexion contracture (HP:0002987)1.59299280
168Deep palmar crease (HP:0006191)1.58954274
169Hypoplasia of the pons (HP:0012110)1.58778949
170Resting tremor (HP:0002322)1.58198709
171Ragged-red muscle fibers (HP:0003200)1.58178359
172Abnormality of polysaccharide metabolism (HP:0011012)1.57670894
173Abnormality of glycosaminoglycan metabolism (HP:0004371)1.57670894
174Abnormality of mucopolysaccharide metabolism (HP:0011020)1.57670894
175Posterior subcapsular cataract (HP:0007787)1.57458825
176Abnormality of the pancreatic islet cells (HP:0006476)1.57388401
177Abnormality of endocrine pancreas physiology (HP:0012093)1.57388401
178Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.57291206
179Absent epiphyses (HP:0010577)1.57291206
180Abnormality of monocarboxylic acid metabolism (HP:0010996)1.55808838
181Reticulocytosis (HP:0001923)1.54913097
182Increased serum lactate (HP:0002151)1.54839492
183Vascular calcification (HP:0004934)1.54548986
184Short clavicles (HP:0000894)1.53445346
185Recurrent otitis media (HP:0000403)1.52290245
186Delayed CNS myelination (HP:0002188)1.51719037
187Severe muscular hypotonia (HP:0006829)1.51016037
188Abnormal number of erythroid precursors (HP:0012131)1.50181944
189Distal lower limb muscle weakness (HP:0009053)1.49951715
190Hyperactive renin-angiotensin system (HP:0000841)1.49855165
191Cerebellar dysplasia (HP:0007033)1.49045631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.41600399
2PRKD33.17767211
3NTRK33.17418091
4NME23.13094645
5PIM23.12300175
6MAP3K93.11071764
7VRK22.50927357
8SCYL22.47856223
9MST1R2.41676694
10KSR22.33034245
11SMG12.31328082
12MAP3K22.27714604
13BUB12.19779407
14MAPK152.16186960
15CAMKK12.06333745
16IRAK32.05656330
17MAPKAPK32.02777625
18EPHA41.99432847
19MINK11.96227876
20MARK11.95915296
21PAK61.95090073
22ERN11.92334149
23DAPK21.87798483
24PKN21.83636110
25PDK21.76958570
26RIPK11.75360374
27CDK121.74460148
28NTRK11.73683229
29NEK11.73085943
30MAP3K41.59640349
31LMTK21.42317842
32KSR11.41941672
33STK381.39543201
34CAMKK21.38835110
35DDR21.37348208
36FER1.36504346
37MET1.36131170
38PBK1.31505896
39PDGFRA1.29928052
40TNK21.29906830
41EEF2K1.29079771
42MAP3K111.28886952
43ALK1.26234587
44TESK11.24753254
45BRAF1.24045262
46TAOK11.23215898
47LATS21.21657404
48UHMK11.21231055
49CDK51.19052041
50BCKDK1.18548279
51PASK1.18476861
52ARAF1.15990761
53TLK11.15808503
54AURKA1.13785682
55TYRO31.13326656
56CDK191.10962714
57PTK61.07878144
58SIK11.07444706
59TAOK21.06978070
60PHKG11.04994837
61PHKG21.04994837
62STK161.04788334
63PTK21.04658028
64WNK41.04483028
65RET1.04132256
66EIF2AK11.03582008
67PAK31.01748545
68WNK30.98731585
69SIK20.98064030
70NTRK20.97405310
71HIPK20.96410006
72TTK0.94187040
73CAMK1G0.91523616
74RPS6KB20.90899740
75MAP3K10.89383013
76DAPK10.87946257
77MAPKAPK50.86711703
78CDK150.86174661
79CSNK1G30.85747884
80CDK140.85568360
81CDK11A0.83507849
82CDK180.83357270
83MST40.82602979
84CDK70.81372093
85FRK0.78947053
86PRKCH0.78822991
87CAMK1D0.77982076
88FGFR10.77436913
89PRKCI0.77102791
90ILK0.74838978
91DAPK30.73449323
92PRKCG0.73129921
93CDC42BPA0.72035248
94AKT20.71272814
95ABL20.70742618
96LIMK10.70566834
97CAMK10.69895074
98GRK60.68506125
99EPHA20.68149721
100PAK20.67089584
101LRRK20.66960941
102MAP2K60.63866184
103DYRK1A0.61247663
104MAP2K10.60990082
105PDPK10.60317514
106ERBB40.59336106
107SRPK10.59299110
108ZAK0.58963774
109MAP3K100.58805036
110MARK20.58332288
111EPHB20.57070793
112RPS6KA50.57068784
113MAP2K40.55709959
114MAPK110.55624044
115BRSK10.55264537
116TBK10.55210535
117PRKD20.54694010
118MTOR0.53758311
119ICK0.52315636
120RPS6KA20.51358633
121MAP2K70.50933108
122STK110.50268591
123CAMK2G0.49827245
124FGFR40.48123712
125MAP3K80.47110856
126DYRK1B0.46764090
127CSNK1A1L0.46543265
128PDK10.45822381
129NEK60.45578423
130NME10.43667313
131PRKCZ0.43435273
132CSNK1G10.43313222
133CSNK1E0.42610779
134BMX0.42610171
135AURKB0.42203072
136KDR0.40825771
137MAP3K120.40605576
138TESK20.40506225
139TSSK60.40407522
140PAK40.40296073
141MUSK0.40061049
142FYN0.39661436
143MAP2K20.39334383
144CDK80.39313430
145CHEK20.39177565
146PLK10.38905145
147PRPF4B0.38546677
148PAK10.38334492
149RAF10.38029136
150WNK10.37315657
151CSNK1G20.34297716
152MAP3K30.32273675
153ATR0.29424135
154MAP3K60.26642444
155CDK90.25663321
156CHEK10.24663018
157AKT30.24231898
158CAMK2B0.23462918
159EPHB10.22492738

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.88601483
2Sulfur relay system_Homo sapiens_hsa041222.86701399
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.77977420
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.56501700
5Insulin secretion_Homo sapiens_hsa049112.40438383
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32741664
7Base excision repair_Homo sapiens_hsa034102.32139067
8Fructose and mannose metabolism_Homo sapiens_hsa000512.25325743
9Biosynthesis of amino acids_Homo sapiens_hsa012302.12935943
10Phenylalanine metabolism_Homo sapiens_hsa003602.10746520
11GABAergic synapse_Homo sapiens_hsa047272.04227583
12Circadian entrainment_Homo sapiens_hsa047132.03023144
13Pancreatic secretion_Homo sapiens_hsa049722.01039881
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.99733780
15Long-term potentiation_Homo sapiens_hsa047201.97667836
16Olfactory transduction_Homo sapiens_hsa047401.89869804
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.82433689
18Dopaminergic synapse_Homo sapiens_hsa047281.80429253
19Vibrio cholerae infection_Homo sapiens_hsa051101.80411638
20Amphetamine addiction_Homo sapiens_hsa050311.79519375
21Gastric acid secretion_Homo sapiens_hsa049711.76387214
22Other glycan degradation_Homo sapiens_hsa005111.75988562
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74956472
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71533908
25Cocaine addiction_Homo sapiens_hsa050301.69613513
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67197836
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.65448631
28Cholinergic synapse_Homo sapiens_hsa047251.65029696
29Nicotine addiction_Homo sapiens_hsa050331.64369479
30Glutathione metabolism_Homo sapiens_hsa004801.64309875
31Morphine addiction_Homo sapiens_hsa050321.64116220
32Pyrimidine metabolism_Homo sapiens_hsa002401.63778287
33Glutamatergic synapse_Homo sapiens_hsa047241.63387847
34Sulfur metabolism_Homo sapiens_hsa009201.62220557
35Proteasome_Homo sapiens_hsa030501.61450410
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61200297
37DNA replication_Homo sapiens_hsa030301.58741803
38Salivary secretion_Homo sapiens_hsa049701.57166023
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55821301
40RNA polymerase_Homo sapiens_hsa030201.54611037
41Folate biosynthesis_Homo sapiens_hsa007901.53547325
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.52702175
43Pyruvate metabolism_Homo sapiens_hsa006201.51867865
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.50630802
45Tyrosine metabolism_Homo sapiens_hsa003501.48418486
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43995595
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43406054
48Selenocompound metabolism_Homo sapiens_hsa004501.42612737
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37035977
50Type II diabetes mellitus_Homo sapiens_hsa049301.35970101
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35670698
52Ribosome_Homo sapiens_hsa030101.33884734
53Protein digestion and absorption_Homo sapiens_hsa049741.32177157
54Estrogen signaling pathway_Homo sapiens_hsa049151.31093097
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28988432
56Gap junction_Homo sapiens_hsa045401.28488199
57GnRH signaling pathway_Homo sapiens_hsa049121.27109784
58Thyroid hormone synthesis_Homo sapiens_hsa049181.26578064
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.26558596
60N-Glycan biosynthesis_Homo sapiens_hsa005101.24906813
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24757978
62Carbon metabolism_Homo sapiens_hsa012001.24415794
63Nucleotide excision repair_Homo sapiens_hsa034201.24025102
64Huntingtons disease_Homo sapiens_hsa050161.23485372
65Glioma_Homo sapiens_hsa052141.21720661
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20177618
67Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19906184
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.19644596
69Fatty acid elongation_Homo sapiens_hsa000621.19178487
70Pentose phosphate pathway_Homo sapiens_hsa000301.17515362
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13118725
72Oxytocin signaling pathway_Homo sapiens_hsa049211.12690321
73Melanogenesis_Homo sapiens_hsa049161.11899529
74mTOR signaling pathway_Homo sapiens_hsa041501.11265345
75Steroid biosynthesis_Homo sapiens_hsa001001.09377991
76Long-term depression_Homo sapiens_hsa047301.09301973
77Arginine biosynthesis_Homo sapiens_hsa002201.07693081
78Spliceosome_Homo sapiens_hsa030401.04124122
79Renin secretion_Homo sapiens_hsa049241.03495565
80Taste transduction_Homo sapiens_hsa047421.03178616
81Collecting duct acid secretion_Homo sapiens_hsa049661.01856080
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99634395
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99066431
84Sphingolipid metabolism_Homo sapiens_hsa006000.98416715
85Endometrial cancer_Homo sapiens_hsa052130.97446646
86Peroxisome_Homo sapiens_hsa041460.97235456
87Arginine and proline metabolism_Homo sapiens_hsa003300.93471735
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91181526
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.90551625
90RNA transport_Homo sapiens_hsa030130.89162132
91ErbB signaling pathway_Homo sapiens_hsa040120.89075220
92Glucagon signaling pathway_Homo sapiens_hsa049220.88147879
93Oxidative phosphorylation_Homo sapiens_hsa001900.87859080
94Phototransduction_Homo sapiens_hsa047440.87597123
95Bladder cancer_Homo sapiens_hsa052190.87079286
96cAMP signaling pathway_Homo sapiens_hsa040240.86365991
97Calcium signaling pathway_Homo sapiens_hsa040200.86240322
98Oocyte meiosis_Homo sapiens_hsa041140.86080593
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.85131499
100Metabolic pathways_Homo sapiens_hsa011000.83803553
101beta-Alanine metabolism_Homo sapiens_hsa004100.83551175
102Vitamin digestion and absorption_Homo sapiens_hsa049770.83400809
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81621728
104Purine metabolism_Homo sapiens_hsa002300.81531755
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81515482
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81280063
107Serotonergic synapse_Homo sapiens_hsa047260.80815956
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79815826
109One carbon pool by folate_Homo sapiens_hsa006700.78410897
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77752452
111Chemical carcinogenesis_Homo sapiens_hsa052040.77514671
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76798000
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76721290
114Non-small cell lung cancer_Homo sapiens_hsa052230.75678186
115Protein export_Homo sapiens_hsa030600.75135567
116Endocytosis_Homo sapiens_hsa041440.74795871
117VEGF signaling pathway_Homo sapiens_hsa043700.74654704
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.74481249
119Alcoholism_Homo sapiens_hsa050340.72559444
120Nitrogen metabolism_Homo sapiens_hsa009100.69714519
121Axon guidance_Homo sapiens_hsa043600.69482210
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69387142
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68708963
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.66981109
125Tight junction_Homo sapiens_hsa045300.66899295
126Insulin signaling pathway_Homo sapiens_hsa049100.66788508
127Lysosome_Homo sapiens_hsa041420.66468573
128Histidine metabolism_Homo sapiens_hsa003400.65955798
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65295079
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64946620
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62225531
132Mismatch repair_Homo sapiens_hsa034300.60505643
133Renal cell carcinoma_Homo sapiens_hsa052110.60322480
134Proteoglycans in cancer_Homo sapiens_hsa052050.60310120
135Thyroid cancer_Homo sapiens_hsa052160.58767441
136Wnt signaling pathway_Homo sapiens_hsa043100.57769386
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57669239
138Parkinsons disease_Homo sapiens_hsa050120.56865362
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56593664
1402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56218993
141Rap1 signaling pathway_Homo sapiens_hsa040150.55837546
142Hippo signaling pathway_Homo sapiens_hsa043900.54849805
143Fatty acid metabolism_Homo sapiens_hsa012120.52177430
144Colorectal cancer_Homo sapiens_hsa052100.51705038
145Dilated cardiomyopathy_Homo sapiens_hsa054140.50902912
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50805258
147Lysine degradation_Homo sapiens_hsa003100.49331883
148Choline metabolism in cancer_Homo sapiens_hsa052310.48333782
149Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48253179
150Focal adhesion_Homo sapiens_hsa045100.48190433
151AMPK signaling pathway_Homo sapiens_hsa041520.47917634
152Chronic myeloid leukemia_Homo sapiens_hsa052200.46977534
153Inositol phosphate metabolism_Homo sapiens_hsa005620.46968769
154Fat digestion and absorption_Homo sapiens_hsa049750.46563046
155Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45568350
156Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44176319
157Primary bile acid biosynthesis_Homo sapiens_hsa001200.43798077
158Non-homologous end-joining_Homo sapiens_hsa034500.43164423
159Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43135662
160p53 signaling pathway_Homo sapiens_hsa041150.42350830
161Dorso-ventral axis formation_Homo sapiens_hsa043200.42125566
162Galactose metabolism_Homo sapiens_hsa000520.41843105
163Prolactin signaling pathway_Homo sapiens_hsa049170.41803812
164Drug metabolism - other enzymes_Homo sapiens_hsa009830.41191052
165Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40412305
166mRNA surveillance pathway_Homo sapiens_hsa030150.39583712
167Alzheimers disease_Homo sapiens_hsa050100.37034970
168Prion diseases_Homo sapiens_hsa050200.33624483
169Notch signaling pathway_Homo sapiens_hsa043300.28809901
170Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28458498
171Hepatitis C_Homo sapiens_hsa051600.27230092
172Circadian rhythm_Homo sapiens_hsa047100.27058362

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