AQP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to mercury ion (GO:0046689)7.62607157
2urate metabolic process (GO:0046415)7.28167813
3drug transmembrane transport (GO:0006855)7.26760486
4lysine metabolic process (GO:0006553)7.21847305
5lysine catabolic process (GO:0006554)7.21847305
6aminoglycoside antibiotic metabolic process (GO:0030647)7.16686734
7renal absorption (GO:0070293)6.94201364
8* excretion (GO:0007588)6.78963805
9phosphate ion transport (GO:0006817)6.62907459
10metanephric nephron tubule development (GO:0072234)6.58767542
11metanephric tubule development (GO:0072170)6.58767542
12behavioral response to nicotine (GO:0035095)6.55093268
13polyol transport (GO:0015791)6.54852936
14organic cation transport (GO:0015695)6.30829864
15drug transport (GO:0015893)6.10000975
16metanephric nephron epithelium development (GO:0072243)6.02575309
17phosphate ion transmembrane transport (GO:0035435)5.61237184
18metanephric epithelium development (GO:0072207)5.49569326
19quaternary ammonium group transport (GO:0015697)5.41354005
20aspartate family amino acid catabolic process (GO:0009068)5.23942150
21sodium ion export (GO:0071436)5.13577760
22cellular potassium ion homeostasis (GO:0030007)5.02458139
23tricarboxylic acid metabolic process (GO:0072350)5.02216872
24glyoxylate metabolic process (GO:0046487)5.01651833
25exogenous drug catabolic process (GO:0042738)4.80832958
26collecting duct development (GO:0072044)4.79861138
27drug catabolic process (GO:0042737)4.78586923
28nephron tubule development (GO:0072080)4.73271390
29fucose catabolic process (GO:0019317)4.70752947
30L-fucose metabolic process (GO:0042354)4.70752947
31L-fucose catabolic process (GO:0042355)4.70752947
32cysteine metabolic process (GO:0006534)4.54388457
33actin filament depolymerization (GO:0030042)4.51688839
34short-chain fatty acid metabolic process (GO:0046459)4.45806243
35nonribosomal peptide biosynthetic process (GO:0019184)4.41269821
36branched-chain amino acid metabolic process (GO:0009081)4.28308036
372-oxoglutarate metabolic process (GO:0006103)4.20596419
38amino-acid betaine transport (GO:0015838)4.20162699
39carnitine transport (GO:0015879)4.20162699
40renal tubule development (GO:0061326)4.16944674
41response to parathyroid hormone (GO:0071107)4.07495489
42one-carbon compound transport (GO:0019755)4.05609211
43cell volume homeostasis (GO:0006884)4.04171892
44glutathione biosynthetic process (GO:0006750)4.01516530
45NADH metabolic process (GO:0006734)3.93938719
46valine metabolic process (GO:0006573)3.84003546
47kynurenine metabolic process (GO:0070189)3.80830112
48nephron epithelium development (GO:0072009)3.78022828
49serotonin metabolic process (GO:0042428)3.77969132
50cellular ketone body metabolic process (GO:0046950)3.77288663
51indolalkylamine metabolic process (GO:0006586)3.76967301
52vitamin D metabolic process (GO:0042359)3.76424099
53tricarboxylic acid cycle (GO:0006099)3.75173345
54protein polyglutamylation (GO:0018095)3.69767599
55membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.69315118
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.67886382
57indole-containing compound metabolic process (GO:0042430)3.64168824
58primary amino compound metabolic process (GO:1901160)3.63031392
59toxin transport (GO:1901998)3.62303371
60trivalent inorganic anion homeostasis (GO:0072506)3.61971365
61phosphate ion homeostasis (GO:0055062)3.61971365
62branched-chain amino acid catabolic process (GO:0009083)3.61784011
63water-soluble vitamin biosynthetic process (GO:0042364)3.58995053
64cellular modified amino acid catabolic process (GO:0042219)3.57475810
65amino-acid betaine metabolic process (GO:0006577)3.55101906
66negative regulation of telomere maintenance (GO:0032205)3.53883865
67sodium ion transport (GO:0006814)3.53295867
68glutamate metabolic process (GO:0006536)3.53239453
69nephron tubule morphogenesis (GO:0072078)3.48326000
70nephron epithelium morphogenesis (GO:0072088)3.48326000
71gamma-aminobutyric acid transport (GO:0015812)3.46251499
72homocysteine metabolic process (GO:0050667)3.44512927
73fatty acid beta-oxidation (GO:0006635)3.43835848
74cerebellar granule cell differentiation (GO:0021707)3.42912290
75potassium ion import (GO:0010107)3.41599004
76succinate metabolic process (GO:0006105)3.40775780
77auditory behavior (GO:0031223)3.37069941
78proline metabolic process (GO:0006560)3.36364985
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.34418774
80L-phenylalanine metabolic process (GO:0006558)3.34418774
81fructose metabolic process (GO:0006000)3.33625062
82carnitine metabolic process (GO:0009437)3.32822947
83pyrimidine nucleobase catabolic process (GO:0006208)3.32228244
84detection of light stimulus involved in visual perception (GO:0050908)3.31919846
85detection of light stimulus involved in sensory perception (GO:0050962)3.31919846
86modified amino acid transport (GO:0072337)3.29144426
87piRNA metabolic process (GO:0034587)3.29113402
88aromatic amino acid family catabolic process (GO:0009074)3.28790616
89tryptophan catabolic process (GO:0006569)3.27905606
90indole-containing compound catabolic process (GO:0042436)3.27905606
91indolalkylamine catabolic process (GO:0046218)3.27905606
92membrane repolarization during action potential (GO:0086011)3.27285762
93cellular sodium ion homeostasis (GO:0006883)3.26831782
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.25516031
95L-phenylalanine catabolic process (GO:0006559)3.25516031
96platelet dense granule organization (GO:0060155)3.24148927
97ketone body metabolic process (GO:1902224)3.21910442
98serine family amino acid catabolic process (GO:0009071)3.21136299
99acetyl-CoA metabolic process (GO:0006084)3.17329198
100protein localization to cilium (GO:0061512)3.16137141
101cornea development in camera-type eye (GO:0061303)3.15413541
102postsynaptic membrane organization (GO:0001941)3.14358081
103fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.13729408
104synaptic transmission, cholinergic (GO:0007271)3.12929661
105fatty acid oxidation (GO:0019395)3.12576866
106dicarboxylic acid biosynthetic process (GO:0043650)3.12528092
107regulation of gene silencing by RNA (GO:0060966)3.11980438
108regulation of posttranscriptional gene silencing (GO:0060147)3.11980438
109regulation of gene silencing by miRNA (GO:0060964)3.11980438
110lipid oxidation (GO:0034440)3.09207947
111inositol metabolic process (GO:0006020)3.09084219
112preassembly of GPI anchor in ER membrane (GO:0016254)3.07753305
113peptide biosynthetic process (GO:0043043)3.06452886
114response to pheromone (GO:0019236)3.06363510
115cell communication by electrical coupling (GO:0010644)3.05584879
116renal tubule morphogenesis (GO:0061333)3.04748569
117tryptophan metabolic process (GO:0006568)3.04659752
118glycoside metabolic process (GO:0016137)3.04643545
119neuronal action potential (GO:0019228)3.03909581
120response to water (GO:0009415)3.02731973
121regulation of rhodopsin mediated signaling pathway (GO:0022400)3.02515555
122bicarbonate transport (GO:0015701)2.99950872
123negative regulation of hormone biosynthetic process (GO:0032353)2.99303339
124negative regulation of hormone metabolic process (GO:0032351)2.99303339
125cAMP catabolic process (GO:0006198)2.98685086
126DNA deamination (GO:0045006)2.98619284
127detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98524187
128rhodopsin mediated signaling pathway (GO:0016056)2.97739961
129potassium ion homeostasis (GO:0055075)2.96858131
130axoneme assembly (GO:0035082)2.96345456
131oxaloacetate metabolic process (GO:0006107)2.95805788
132membrane repolarization (GO:0086009)2.94515562
133locomotory exploration behavior (GO:0035641)2.94153026
134serine family amino acid metabolic process (GO:0009069)2.91533098
135behavioral response to ethanol (GO:0048149)2.90166925
136protein-cofactor linkage (GO:0018065)2.86529573
137mannosylation (GO:0097502)2.85781219
138DNA methylation involved in gamete generation (GO:0043046)2.84540497
139nucleobase catabolic process (GO:0046113)2.83082321
140mechanosensory behavior (GO:0007638)2.82980113
141protein K11-linked deubiquitination (GO:0035871)2.80812395
142protein complex biogenesis (GO:0070271)2.80241062
143cellular biogenic amine catabolic process (GO:0042402)2.79677743
144amine catabolic process (GO:0009310)2.79677743
145mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76643539
146mitochondrial respiratory chain complex I assembly (GO:0032981)2.76643539
147NADH dehydrogenase complex assembly (GO:0010257)2.76643539
148epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.76487218
149reflex (GO:0060004)2.73459232
150rRNA catabolic process (GO:0016075)2.72963024
151negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71799720
152kidney morphogenesis (GO:0060993)2.68318332
153cyclic nucleotide catabolic process (GO:0009214)2.65417991
154negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64622178
155transmission of nerve impulse (GO:0019226)2.63648007
156protein localization to synapse (GO:0035418)2.63393236
157retinal cone cell development (GO:0046549)2.61791213
158regulation of nuclear cell cycle DNA replication (GO:0033262)2.61341892
159mitochondrial respiratory chain complex assembly (GO:0033108)2.59255828
160epithelial cilium movement (GO:0003351)2.59254304
161cullin deneddylation (GO:0010388)2.56458936
162C4-dicarboxylate transport (GO:0015740)2.56204592
163neurotransmitter metabolic process (GO:0042133)2.56116751
164regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.55057660
165regulation of mitotic spindle checkpoint (GO:1903504)2.55057660
166G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54653634
167sulfation (GO:0051923)2.53940138
168transepithelial transport (GO:0070633)2.53113815
169neural tube formation (GO:0001841)2.51192408
170regulation of meiosis I (GO:0060631)2.49149602
171regulation of action potential (GO:0098900)2.49042328
172regulation of synapse structural plasticity (GO:0051823)2.48632402
173regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.47557942
174cilium organization (GO:0044782)2.43330909
175neuron cell-cell adhesion (GO:0007158)2.42387004
176presynaptic membrane assembly (GO:0097105)2.42223863
177purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.41712995
1783-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.41712995
179RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.41156222
180membrane depolarization during action potential (GO:0086010)2.39776537
181fatty acid elongation (GO:0030497)2.39674592
182adaptation of signaling pathway (GO:0023058)2.37853535
183regulation of hexokinase activity (GO:1903299)2.37416981
184regulation of glucokinase activity (GO:0033131)2.37416981
185regulation of hippo signaling (GO:0035330)2.36361572
186glycerophospholipid catabolic process (GO:0046475)2.36079859
187autophagic vacuole fusion (GO:0000046)2.36029168
188inner ear receptor stereocilium organization (GO:0060122)2.35801740
189histone H4-K12 acetylation (GO:0043983)2.35488737
190regulation of telomere maintenance (GO:0032204)2.35385262
191neurotransmitter catabolic process (GO:0042135)2.34824446

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.80926250
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.78461012
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.64759498
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.46759630
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38507661
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.36493127
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31548450
8ERG_21242973_ChIP-ChIP_JURKAT_Human2.18314801
9IGF1R_20145208_ChIP-Seq_DFB_Human2.16788593
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.13825776
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12757292
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10152584
13TAF15_26573619_Chip-Seq_HEK293_Human2.10080588
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09977138
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.09473365
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.08197308
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03608253
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03608253
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03292551
20PPARA_22158963_ChIP-Seq_LIVER_Mouse2.02019851
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00559956
22DROSHA_22980978_ChIP-Seq_HELA_Human1.99216712
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97893955
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95545507
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95518125
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92861959
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.92349132
28EWS_26573619_Chip-Seq_HEK293_Human1.84418205
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84027564
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79728718
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.78732887
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78640794
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76255444
34P300_19829295_ChIP-Seq_ESCs_Human1.76104871
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73363204
36ER_23166858_ChIP-Seq_MCF-7_Human1.72024480
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67319082
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67190897
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67122028
40FUS_26573619_Chip-Seq_HEK293_Human1.66120591
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64051250
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63903734
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.63545400
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63321623
45TP53_22573176_ChIP-Seq_HFKS_Human1.62499530
46* EZH2_27294783_Chip-Seq_ESCs_Mouse1.61623518
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55895785
48* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55107245
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52468864
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.51519320
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50768512
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.49470150
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48351119
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47167526
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47167526
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44945111
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44479523
58STAT3_23295773_ChIP-Seq_U87_Human1.43711769
59MYC_18940864_ChIP-ChIP_HL60_Human1.41470293
60AR_25329375_ChIP-Seq_VCAP_Human1.41217314
61CBP_20019798_ChIP-Seq_JUKART_Human1.41215029
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41215029
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.40957320
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39883227
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39359871
66* FOXA1_25329375_ChIP-Seq_VCAP_Human1.39094432
67* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39094432
68LXR_22292898_ChIP-Seq_THP-1_Human1.38112587
69CLOCK_20551151_ChIP-Seq_293T_Human1.38027531
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37952152
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37588204
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36828811
73BCAT_22108803_ChIP-Seq_LS180_Human1.36546496
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36418869
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36280856
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35840577
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35236742
78EZH2_22144423_ChIP-Seq_EOC_Human1.34675383
79IRF1_19129219_ChIP-ChIP_H3396_Human1.33775013
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.33550124
81VDR_22108803_ChIP-Seq_LS180_Human1.33454938
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.33295597
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32494432
84* TCF4_23295773_ChIP-Seq_U87_Human1.32430051
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31017003
86RNF2_27304074_Chip-Seq_NSC_Mouse1.30808199
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.30731406
88CDX2_20551321_ChIP-Seq_CACO-2_Human1.30690127
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.29583596
90GBX2_23144817_ChIP-Seq_PC3_Human1.29312941
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.29096090
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28513747
93AR_21572438_ChIP-Seq_LNCaP_Human1.27487392
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26640115
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25416984
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25359664
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24823711
98NANOG_19829295_ChIP-Seq_ESCs_Human1.24799110
99SOX2_19829295_ChIP-Seq_ESCs_Human1.24799110
100GATA3_21878914_ChIP-Seq_MCF-7_Human1.24486028
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24388828
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23853088
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23742236
104* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23221850
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.23214986
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22996792
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.22320807
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21943126
109HOXB7_26014856_ChIP-Seq_BT474_Human1.21457043
110CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20653937
111RXR_22108803_ChIP-Seq_LS180_Human1.20286036
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19775061
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18932028
114TRIM28_21343339_ChIP-Seq_HEK293_Human1.17849772
115FOXA2_19822575_ChIP-Seq_HepG2_Human1.17675289
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.16715894
117SMAD4_21741376_ChIP-Seq_HESCs_Human1.16282108
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15597112
119CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15196245
120KDM2B_26808549_Chip-Seq_K562_Human1.15124748
121WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14473202
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14313068
123AR_20517297_ChIP-Seq_VCAP_Human1.14252454
124RUNX2_22187159_ChIP-Seq_PCA_Human1.13920327
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12893335
126NCOR_22424771_ChIP-Seq_293T_Human1.12400398
127REST_21632747_ChIP-Seq_MESCs_Mouse1.12238197
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12202868
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.11969369
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11922729
131TCF4_22108803_ChIP-Seq_LS180_Human1.11409093
132TBX20_22328084_ChIP-Seq_HEART_Mouse1.11307703
133TBX20_22080862_ChIP-Seq_HEART_Mouse1.11307703
134SMAD3_21741376_ChIP-Seq_EPCs_Human1.10797509
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.10380831
136RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10194360
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10078753
138TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09816383
139EZH2_27304074_Chip-Seq_ESCs_Mouse1.06527783
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06271193
141ERA_21632823_ChIP-Seq_H3396_Human1.02726946
142RACK7_27058665_Chip-Seq_MCF-7_Human1.02370092
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02004990
144MYC_19829295_ChIP-Seq_ESCs_Human1.01654407
145ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01530803
146RNF2_27304074_Chip-Seq_ESCs_Mouse1.01510377
147P53_22387025_ChIP-Seq_ESCs_Mouse1.01045315
148FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00485524
149STAT3_18555785_Chip-Seq_ESCs_Mouse1.00353870
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99647972
151FOXH1_21741376_ChIP-Seq_EPCs_Human0.99523501
152CRX_20693478_ChIP-Seq_RETINA_Mouse0.99475993
153NANOG_18555785_Chip-Seq_ESCs_Mouse0.99415220
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.97843390
155FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96592865
156HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95674405
157SMAD4_21741376_ChIP-Seq_EPCs_Human0.95009030
158GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94849598
159AR_19668381_ChIP-Seq_PC3_Human0.94662387
160RING1B_27294783_Chip-Seq_ESCs_Mouse0.94547743
161AHR_22903824_ChIP-Seq_MCF-7_Human0.94012418
162ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92087373
163RING1B_27294783_Chip-Seq_NPCs_Mouse0.91724292
164TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91202305
165HNF4A_19822575_ChIP-Seq_HepG2_Human0.91144632
166SMC4_20622854_ChIP-Seq_HELA_Human0.90983963
167TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87349136
168* TET1_21490601_ChIP-Seq_MESCs_Mouse0.86949667
169SMAD4_21799915_ChIP-Seq_A2780_Human0.86939234
170TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86710935
171ZNF274_21170338_ChIP-Seq_K562_Hela0.85303334
172BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84924309
173* CTCF_27219007_Chip-Seq_Bcells_Human0.84411430
174NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84234756
175P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.84118968
176CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83727658
177SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83466472
178ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82644213
179KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81675315
180ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81064570
181SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79250910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation8.85884041
2MP0003195_calcinosis5.79098180
3MP0005360_urolithiasis4.94601354
4MP0001756_abnormal_urination4.17860738
5MP0005332_abnormal_amino_acid3.94690064
6MP0001765_abnormal_ion_homeostasis3.66729336
7MP0009643_abnormal_urine_homeostasis3.47436946
8MP0004019_abnormal_vitamin_homeostasis3.35839351
9MP0008877_abnormal_DNA_methylation2.98116032
10MP0004885_abnormal_endolymph2.93654579
11MP0002139_abnormal_hepatobiliary_system2.78593108
12MP0002138_abnormal_hepatobiliary_system2.69988995
13MP0005636_abnormal_mineral_homeostasis2.69117113
14MP0005551_abnormal_eye_electrophysiolog2.66587196
15MP0002136_abnormal_kidney_physiology2.62928903
16MP0001986_abnormal_taste_sensitivity2.61772120
17MP0002102_abnormal_ear_morphology2.43775097
18MP0006072_abnormal_retinal_apoptosis2.35868794
19MP0005645_abnormal_hypothalamus_physiol2.27673606
20MP0003787_abnormal_imprinting2.25663119
21MP0002837_dystrophic_cardiac_calcinosis2.23541179
22MP0009046_muscle_twitch2.17062715
23MP0003880_abnormal_central_pattern2.13652124
24MP0008961_abnormal_basal_metabolism2.12432225
25MP0002638_abnormal_pupillary_reflex2.11853064
26MP0005377_hearing/vestibular/ear_phenot2.03802191
27MP0003878_abnormal_ear_physiology2.03802191
28MP0006276_abnormal_autonomic_nervous2.01947015
29MP0005423_abnormal_somatic_nervous1.90052348
30MP0005646_abnormal_pituitary_gland1.85134306
31MP0005253_abnormal_eye_physiology1.75081723
32MP0003252_abnormal_bile_duct1.74677302
33MP0001501_abnormal_sleep_pattern1.71154539
34MP0001958_emphysema1.66847606
35MP0008875_abnormal_xenobiotic_pharmacok1.66536652
36MP0000538_abnormal_urinary_bladder1.62136859
37MP0003122_maternal_imprinting1.48194323
38MP0003283_abnormal_digestive_organ1.48104153
39MP0004859_abnormal_synaptic_plasticity1.47771902
40MP0004147_increased_porphyrin_level1.46754848
41MP0001984_abnormal_olfaction1.45967721
42MP0005584_abnormal_enzyme/coenzyme_acti1.45006386
43MP0003136_yellow_coat_color1.45003468
44MP0004742_abnormal_vestibular_system1.44748581
45MP0003011_delayed_dark_adaptation1.44648898
46MP0004133_heterotaxia1.43896866
47MP0002733_abnormal_thermal_nociception1.42877537
48MP0001970_abnormal_pain_threshold1.42068390
49MP0000631_abnormal_neuroendocrine_gland1.40022974
50MP0000427_abnormal_hair_cycle1.39568604
51MP0002909_abnormal_adrenal_gland1.38747679
52MP0003646_muscle_fatigue1.35666102
53MP0002168_other_aberrant_phenotype1.35313280
54MP0001529_abnormal_vocalization1.33645553
55MP0002653_abnormal_ependyma_morphology1.30581265
56MP0001905_abnormal_dopamine_level1.30425281
57MP0002557_abnormal_social/conspecific_i1.28749510
58MP0001188_hyperpigmentation1.28141362
59MP0006292_abnormal_olfactory_placode1.23498299
60MP0003635_abnormal_synaptic_transmissio1.22355253
61MP0008569_lethality_at_weaning1.22199993
62MP0002067_abnormal_sensory_capabilities1.21668109
63MP0000569_abnormal_digit_pigmentation1.20343694
64MP0003121_genomic_imprinting1.19605290
65MP0005379_endocrine/exocrine_gland_phen1.19223286
66MP0005058_abnormal_lysosome_morphology1.18859386
67MP0005451_abnormal_body_composition1.17700763
68MP0003329_amyloid_beta_deposits1.17613986
69MP0000230_abnormal_systemic_arterial1.17248999
70MP0005535_abnormal_body_temperature1.16586915
71MP0005174_abnormal_tail_pigmentation1.16561764
72MP0002064_seizures1.15410670
73MP0002163_abnormal_gland_morphology1.11974435
74MP0005365_abnormal_bile_salt1.11499296
75MP0006036_abnormal_mitochondrial_physio1.09822460
76MP0002089_abnormal_postnatal_growth/wei1.09819433
77MP0001502_abnormal_circadian_rhythm1.09732490
78MP0010234_abnormal_vibrissa_follicle1.09046692
79MP0005195_abnormal_posterior_eye1.07663953
80MP0002938_white_spotting1.06955979
81MP0002751_abnormal_autonomic_nervous1.06644113
82MP0002184_abnormal_innervation1.06300251
83MP0009745_abnormal_behavioral_response1.06061550
84MP0004924_abnormal_behavior1.03108402
85MP0005386_behavior/neurological_phenoty1.03108402
86MP0002876_abnormal_thyroid_physiology1.02897410
87MP0003879_abnormal_hair_cell1.02088403
88MP0001440_abnormal_grooming_behavior0.98741537
89MP0000778_abnormal_nervous_system0.98565382
90MP0002272_abnormal_nervous_system0.97793255
91MP0004215_abnormal_myocardial_fiber0.97333444
92MP0000372_irregular_coat_pigmentation0.95146774
93MP0005085_abnormal_gallbladder_physiolo0.94900717
94MP0005389_reproductive_system_phenotype0.94535732
95MP0002735_abnormal_chemical_nociception0.94222200
96MP0005671_abnormal_response_to0.93130926
97MP0004484_altered_response_of0.93087066
98MP0002752_abnormal_somatic_nervous0.92225560
99MP0001919_abnormal_reproductive_system0.92004755
100MP0004145_abnormal_muscle_electrophysio0.90376678
101MP0000534_abnormal_ureter_morphology0.88818164
102MP0003137_abnormal_impulse_conducting0.88804121
103MP0000747_muscle_weakness0.86324795
104MP0005410_abnormal_fertilization0.86204096
105MP0002135_abnormal_kidney_morphology0.85502659
106MP0002928_abnormal_bile_duct0.85265645
107MP0000026_abnormal_inner_ear0.83854877
108MP0004233_abnormal_muscle_weight0.83207544
109MP0002160_abnormal_reproductive_system0.82667761
110MP0002069_abnormal_eating/drinking_beha0.81183602
111MP0002736_abnormal_nociception_after0.81122249
112MP0002734_abnormal_mechanical_nocicepti0.80424249
113MP0003638_abnormal_response/metabolism_0.79958480
114MP0005319_abnormal_enzyme/_coenzyme0.79873364
115MP0002693_abnormal_pancreas_physiology0.79328496
116MP0008872_abnormal_physiological_respon0.79157340
117MP0002063_abnormal_learning/memory/cond0.79157177
118MP0002882_abnormal_neuron_morphology0.78220136
119MP0000751_myopathy0.77413306
120MP0003698_abnormal_male_reproductive0.75435175
121MP0002896_abnormal_bone_mineralization0.74916468
122MP0003300_gastrointestinal_ulcer0.74781333
123MP0001270_distended_abdomen0.74715239
124MP0001485_abnormal_pinna_reflex0.72074817
125MP0004085_abnormal_heartbeat0.71827419
126MP0001486_abnormal_startle_reflex0.71772133
127MP0004270_analgesia0.71676453
128MP0002066_abnormal_motor_capabilities/c0.71501656
129MP0001968_abnormal_touch/_nociception0.71166138
130MP0008775_abnormal_heart_ventricle0.69525725
131MP0005084_abnormal_gallbladder_morpholo0.69482308
132MP0004142_abnormal_muscle_tone0.68856951
133MP0010386_abnormal_urinary_bladder0.67758712
134MP0003632_abnormal_nervous_system0.66651396
135MP0005666_abnormal_adipose_tissue0.66551668
136MP0003186_abnormal_redox_activity0.66121743
137MP0002572_abnormal_emotion/affect_behav0.64584749
138MP0000920_abnormal_myelination0.62645169
139MP0003633_abnormal_nervous_system0.62437782
140MP0006035_abnormal_mitochondrial_morpho0.61968759
141MP0001963_abnormal_hearing_physiology0.61932628
142MP0004084_abnormal_cardiac_muscle0.61292620
143MP0004858_abnormal_nervous_system0.60072663
144MP0003172_abnormal_lysosome_physiology0.59271737
145MP0003631_nervous_system_phenotype0.58842231
146MP0005083_abnormal_biliary_tract0.55838559
147MP0005395_other_phenotype0.55636799
148MP0002118_abnormal_lipid_homeostasis0.54660155
149MP0002972_abnormal_cardiac_muscle0.53809745
150MP0005167_abnormal_blood-brain_barrier0.53676563
151MP0003191_abnormal_cellular_cholesterol0.53424211
152MP0000678_abnormal_parathyroid_gland0.52798497
153MP0002229_neurodegeneration0.51101061
154MP0009642_abnormal_blood_homeostasis0.49210705
155MP0003690_abnormal_glial_cell0.48406778
156MP0001177_atelectasis0.46857789
157MP0004036_abnormal_muscle_relaxation0.46723192

Predicted human phenotypes

RankGene SetZ-score
1Hypokalemic alkalosis (HP:0001949)9.62366441
2Increased circulating renin level (HP:0000848)8.82116461
3Abnormality of chloride homeostasis (HP:0011422)8.06924421
4Hyperactive renin-angiotensin system (HP:0000841)8.06138189
5Polyuria (HP:0000103)7.98350978
6Hypomagnesemia (HP:0002917)7.81391346
7Abnormal urine output (HP:0012590)7.41124462
8Renal salt wasting (HP:0000127)6.74468524
9Abnormality of renal excretion (HP:0011036)6.71327566
10Hyperaldosteronism (HP:0000859)6.67077606
11Abnormality of magnesium homeostasis (HP:0004921)6.60478236
12Polydipsia (HP:0001959)6.26758506
13Abnormal drinking behavior (HP:0030082)6.26758506
14Tetany (HP:0001281)6.14201364
15Gout (HP:0001997)5.92062358
16Alkalosis (HP:0001948)5.76939113
17Abnormality of renin-angiotensin system (HP:0000847)5.54223455
18Congenital stationary night blindness (HP:0007642)5.17680081
19Hypokalemia (HP:0002900)4.68482617
20Hyperuricemia (HP:0002149)4.14875817
21Increased purine levels (HP:0004368)4.14875817
22Type II lissencephaly (HP:0007260)3.98110715
23Pancreatic cysts (HP:0001737)3.87881177
24Abnormality of potassium homeostasis (HP:0011042)3.80324708
25Hypercalciuria (HP:0002150)3.80196292
26Abnormality of sodium homeostasis (HP:0010931)3.65107532
27Nephronophthisis (HP:0000090)3.55619366
28Molar tooth sign on MRI (HP:0002419)3.47714417
29Abnormality of midbrain morphology (HP:0002418)3.47714417
30Proximal tubulopathy (HP:0000114)3.42057270
31Hyperglycinuria (HP:0003108)3.39198664
32Pancreatic fibrosis (HP:0100732)3.33766799
33Adrenal overactivity (HP:0002717)3.31415891
34Abnormality of purine metabolism (HP:0004352)3.29979119
35Attenuation of retinal blood vessels (HP:0007843)3.25593065
36True hermaphroditism (HP:0010459)3.23631769
37Hyponatremia (HP:0002902)3.18444676
38Abnormality of the renal medulla (HP:0100957)3.14028895
39Abnormality of fatty-acid metabolism (HP:0004359)3.13538628
40Ketoacidosis (HP:0001993)2.95356582
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.93126635
42Abnormal rod and cone electroretinograms (HP:0008323)2.92741214
43Cerebellar dysplasia (HP:0007033)2.89713068
44Abnormality of the pons (HP:0007361)2.86838199
45Hyperalaninemia (HP:0003348)2.81209234
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81209234
47Abnormality of alanine metabolism (HP:0010916)2.81209234
48Hypoplasia of the pons (HP:0012110)2.80178583
49Severe muscular hypotonia (HP:0006829)2.74271893
50Abnormality of glycine metabolism (HP:0010895)2.73938438
51Abnormality of serine family amino acid metabolism (HP:0010894)2.73938438
52Nephrocalcinosis (HP:0000121)2.73683117
53Congenital, generalized hypertrichosis (HP:0004540)2.72847756
54Lissencephaly (HP:0001339)2.67458799
55Inability to walk (HP:0002540)2.66384245
56Renal tubular acidosis (HP:0001947)2.64329288
57Abolished electroretinogram (ERG) (HP:0000550)2.58408550
58Dehydration (HP:0001944)2.54632706
59Generalized aminoaciduria (HP:0002909)2.51190170
60Large for gestational age (HP:0001520)2.50365754
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.43513140
62Medial flaring of the eyebrow (HP:0010747)2.41944897
63Decreased circulating renin level (HP:0003351)2.40110971
64Hemiparesis (HP:0001269)2.39688238
65Ketosis (HP:0001946)2.39374216
66Pachygyria (HP:0001302)2.37132660
67Pendular nystagmus (HP:0012043)2.36987535
68Decreased central vision (HP:0007663)2.32146118
69Abnormality of macular pigmentation (HP:0008002)2.21048818
70Hypothermia (HP:0002045)2.20467934
71Abnormality of nucleobase metabolism (HP:0010932)2.20304039
72Bony spicule pigmentary retinopathy (HP:0007737)2.20020981
73Glycosuria (HP:0003076)2.19563617
74Abnormality of urine glucose concentration (HP:0011016)2.19563617
75Progressive inability to walk (HP:0002505)2.19334598
76Chondrocalcinosis (HP:0000934)2.17440239
77Delayed CNS myelination (HP:0002188)2.15662526
78Cystic liver disease (HP:0006706)2.13266788
79Chronic hepatic failure (HP:0100626)2.13016559
80Aplasia/Hypoplasia of the fovea (HP:0008060)2.09909898
81Hypoplasia of the fovea (HP:0007750)2.09909898
82Chorioretinal atrophy (HP:0000533)2.08809618
83Keratoconus (HP:0000563)2.07840879
84Increased corneal curvature (HP:0100692)2.07840879
85Broad-based gait (HP:0002136)2.06955164
86Gait imbalance (HP:0002141)2.06513618
87Vomiting (HP:0002013)2.04733774
88Abnormality of Sharpey fibers (HP:0100685)2.04050259
89Acute necrotizing encephalopathy (HP:0006965)2.03284540
90Renal cortical cysts (HP:0000803)2.03251214
91Rib fusion (HP:0000902)2.02353965
92Increased CSF lactate (HP:0002490)2.02255927
93Neonatal onset (HP:0003623)2.02152410
94Dynein arm defect of respiratory motile cilia (HP:0012255)2.01129026
95Absent/shortened dynein arms (HP:0200106)2.01129026
96Mitochondrial inheritance (HP:0001427)2.00643528
97Hypotension (HP:0002615)2.00152658
98Metabolic alkalosis (HP:0200114)10.2193194
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96265106
100Stomatitis (HP:0010280)1.95873671
101Generalized muscle weakness (HP:0003324)1.95827266
102Hyperphosphaturia (HP:0003109)1.95047585
103Hyperglycinemia (HP:0002154)1.93463961
104Nephrogenic diabetes insipidus (HP:0009806)1.92266102
105Retinal dysplasia (HP:0007973)1.91564622
106Limb dystonia (HP:0002451)1.91311525
107Progressive macrocephaly (HP:0004481)1.91172216
108Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90289424
109Furrowed tongue (HP:0000221)1.89133300
110Tubulointerstitial fibrosis (HP:0005576)1.88858467
111Nephrolithiasis (HP:0000787)1.88636999
112Hydroxyprolinuria (HP:0003080)1.88030161
113Abnormality of proline metabolism (HP:0010907)1.88030161
114Abnormal urine phosphate concentration (HP:0012599)1.88021634
115Congenital primary aphakia (HP:0007707)1.87720787
116Optic disc pallor (HP:0000543)1.87703221
117Confusion (HP:0001289)1.86217390
118Sclerocornea (HP:0000647)1.85706787
119Neuroendocrine neoplasm (HP:0100634)1.84789007
120Gaze-evoked nystagmus (HP:0000640)1.84404059
121Patellar aplasia (HP:0006443)1.83925582
122Mesangial abnormality (HP:0001966)1.81382871
123Absent speech (HP:0001344)1.80999950
124Hepatocellular necrosis (HP:0001404)1.79206530
125Abnormality of the fovea (HP:0000493)1.78528794
126Polyphagia (HP:0002591)1.77737487
127Anencephaly (HP:0002323)1.77088609
128Aplasia/Hypoplasia of the patella (HP:0006498)1.76694897
129Delayed epiphyseal ossification (HP:0002663)1.73979816
130Agitation (HP:0000713)1.73444969
131Congenital hepatic fibrosis (HP:0002612)1.73372168
132Progressive microcephaly (HP:0000253)1.73351604
133Facial shape deformation (HP:0011334)1.72996167
134Potter facies (HP:0002009)1.72996167
135Epileptic encephalopathy (HP:0200134)1.72526994
136Stomach cancer (HP:0012126)1.72407198
137Hyperammonemia (HP:0001987)1.71591892
138Disproportionate short-trunk short stature (HP:0003521)1.71323733
139Hepatic necrosis (HP:0002605)1.71270910
140Tubular atrophy (HP:0000092)1.70007516
141Large eyes (HP:0001090)1.67877345
142Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66132618
143Hypophosphatemia (HP:0002148)1.65787571
144Abnormality of dicarboxylic acid metabolism (HP:0010995)1.62743777
145Dicarboxylic aciduria (HP:0003215)1.62743777
146Metabolic acidosis (HP:0001942)1.61898611
147Vascular calcification (HP:0004934)1.60841247
148Abnormal eating behavior (HP:0100738)1.59144252
149Glomerulosclerosis (HP:0000096)1.56042649
150Action tremor (HP:0002345)1.54351717
151Rickets (HP:0002748)1.52597762
152Irritability (HP:0000737)1.49498103
153Metaphyseal cupping (HP:0003021)1.48929028
154Renal tubular dysfunction (HP:0000124)1.47299458
155Thin bony cortex (HP:0002753)1.46825930
156Hyperkalemia (HP:0002153)1.46626881
157Widely patent fontanelles and sutures (HP:0004492)1.46005050
158Lymphangioma (HP:0100764)1.44822552
159Lethargy (HP:0001254)1.43922984
160Methylmalonic aciduria (HP:0012120)1.41335394
161Cardiovascular calcification (HP:0011915)1.40734689
162Dysmetric saccades (HP:0000641)1.37890488
163Enlarged kidneys (HP:0000105)1.37112253
164Hand muscle atrophy (HP:0009130)1.36871702
165Abnormality of renal resorption (HP:0011038)1.34619550
166Tachypnea (HP:0002789)1.33847570
167Hyperventilation (HP:0002883)1.33553473
168Goiter (HP:0000853)1.31729533
169Intention tremor (HP:0002080)1.29383298
170Malnutrition (HP:0004395)1.28832288
171Status epilepticus (HP:0002133)1.28423570
172Bicornuate uterus (HP:0000813)1.27891829
173Lower limb asymmetry (HP:0100559)1.24777553
174Bilateral sensorineural hearing impairment (HP:0008619)1.23421809
175Progressive cerebellar ataxia (HP:0002073)1.22419166
176Scanning speech (HP:0002168)1.21882358
177Abnormality of the renal cortex (HP:0011035)1.19462345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR17.56389090
2WNK46.88346945
3FRK4.51497540
4ADRBK23.16203980
5ACVR1B3.11766303
6STK392.96389643
7ZAK2.81978210
8MAP4K22.76728309
9WNK12.69149519
10CASK2.43020214
11GRK12.30051004
12SGK2232.27955886
13SGK4942.27955886
14BMPR1B2.23625986
15TLK12.20841070
16SGK22.05090653
17BCKDK2.04958998
18WNK310.0992821
19MAPK131.97432446
20TXK1.85643400
21NUAK11.83013264
22SGK31.78653602
23STK381.63514878
24PDK31.55977869
25PDK41.55977869
26NEK11.50742823
27TRIM281.43610052
28CAMKK21.41044491
29STK38L1.40544534
30TNIK1.39782992
31RIPK11.37649075
32AKT31.36485282
33MKNK21.27665517
34TAOK31.21793470
35ERBB31.15776597
36IRAK41.10469625
37DYRK21.10240846
38PINK11.08430245
39PDK21.07946033
40MAPKAPK31.04927112
41INSRR1.02688088
42ADRBK11.02560364
43MAPK150.98778243
44MAP2K70.89839412
45PRKCE0.88072664
46NME10.88046092
47TSSK60.86240950
48PLK20.83478629
49EPHB10.79765027
50SGK10.76641946
51CAMK1D0.75867017
52MAP2K60.75129708
53MINK10.74699157
54CSNK1G20.73804137
55FGFR20.72822763
56MUSK0.71915723
57IRAK10.70912931
58CAMK2A0.68823094
59TEC0.66730281
60RPS6KA50.64962264
61PTK60.62719219
62MAPKAPK50.61592296
63CAMKK10.61324459
64TGFBR10.60805333
65DAPK20.60686668
66MAP2K20.60461924
67IKBKB0.59920200
68NTRK30.59222052
69MAP3K90.59024085
70TAF10.58367963
71PAK60.57751253
72PRKAA10.57229279
73ITK0.54264695
74PRKCH0.53423859
75FLT30.52968569
76MST1R0.52501406
77MAP2K40.52090628
78PTK20.50950609
79BCR0.46886279
80PAK40.46226801
81PLK40.45588728
82MAP3K40.45434230
83TIE10.44568613
84VRK10.44507371
85PDPK10.43800989
86TRIB30.42241534
87CSNK1G30.41336627
88LRRK20.41318584
89PRKCQ0.40833462
90MKNK10.40710437
91STK110.40699036
92PDK10.39850850
93PRKCG0.39739169
94CSNK1G10.39646152
95KIT0.39414940
96PLK30.38610249
97MST40.38442782
98STK160.37492920
99GSK3A0.36595739
100CAMK40.35451835
101MAP3K70.35046564
102PAK30.34804526
103CHUK0.34275722
104CDK190.31739066
105PRKG10.30056970
106NTRK10.29832690
107PKN10.29587477
108FER0.29498020
109NTRK20.29413535
110EPHA30.28232133
111PNCK0.28091439
112CSNK1D0.27240894
113CAMK2G0.26792291
114DYRK1B0.26461237
115PRKACA0.26438616
116PRKACG0.26196523
117CDK50.25886685
118PRKCZ0.23266646
119PHKG20.22561278
120PHKG10.22561278
121CSNK1A10.20991530
122PTK2B0.20184908
123PRKD20.20017247
124TYRO30.19919076
125ROCK20.19292114
126PRKAA20.19148436
127PRKCD0.18550113
128MARK10.18526447
129RPS6KA30.18462025
130FGFR40.18089681
131RIPK40.17882350
132PRKCA0.17750043
133DAPK10.17636049
134KSR10.17195584
135LMTK20.17127979
136CAMK1G0.16555539
137MAP2K30.16392212
138MAP3K20.16035517
139PRPF4B0.15908880
140SIK20.15355726
141SRC0.15128901
142BMX0.15099966
143GRK60.14813791
144MAPK120.14505133
145PRKCI0.14334827
146KSR20.14109303
147CAMK2B0.13971932
148CAMK10.12881942
149GRK50.12054892
150ALK0.11713939
151TGFBR20.09804102
152RET0.09102074
153JAK20.08448262
154PRKD30.08389014
155FYN0.07946174
156PDGFRA0.07886086
157CDK150.07777031
158MYLK0.07467927
159IRAK20.07055660
160EPHA40.06668943

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.65925312
2Phototransduction_Homo sapiens_hsa047443.38123326
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.12521691
4Butanoate metabolism_Homo sapiens_hsa006503.10764389
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.02489057
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.95525976
7Propanoate metabolism_Homo sapiens_hsa006402.81099296
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74995379
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.69229865
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65500974
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.55947868
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47721635
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45432512
14Linoleic acid metabolism_Homo sapiens_hsa005912.37244650
15Collecting duct acid secretion_Homo sapiens_hsa049662.30501707
16Protein export_Homo sapiens_hsa030602.24277770
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.21650727
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.20208754
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.11457332
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.10364884
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02608228
22Bile secretion_Homo sapiens_hsa049762.02363557
23Fatty acid degradation_Homo sapiens_hsa000711.94305141
24Pyruvate metabolism_Homo sapiens_hsa006201.92485159
25Regulation of autophagy_Homo sapiens_hsa041401.82238790
26Ether lipid metabolism_Homo sapiens_hsa005651.77852785
27Peroxisome_Homo sapiens_hsa041461.67773927
28Carbon metabolism_Homo sapiens_hsa012001.62766563
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62715627
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62597683
31Tryptophan metabolism_Homo sapiens_hsa003801.56968558
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56506477
33Gastric acid secretion_Homo sapiens_hsa049711.55842451
34Caffeine metabolism_Homo sapiens_hsa002321.50088031
35Mineral absorption_Homo sapiens_hsa049781.49765685
36Fatty acid metabolism_Homo sapiens_hsa012121.48372235
37Thyroid hormone synthesis_Homo sapiens_hsa049181.40821474
38Sulfur metabolism_Homo sapiens_hsa009201.39039673
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37430065
40beta-Alanine metabolism_Homo sapiens_hsa004101.35675487
41Synaptic vesicle cycle_Homo sapiens_hsa047211.34889361
42Nitrogen metabolism_Homo sapiens_hsa009101.28408308
43Arginine biosynthesis_Homo sapiens_hsa002201.27401063
44Vitamin digestion and absorption_Homo sapiens_hsa049771.26926639
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25994375
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21288988
47Olfactory transduction_Homo sapiens_hsa047401.21026430
48RNA polymerase_Homo sapiens_hsa030201.20774883
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17711458
50Basal transcription factors_Homo sapiens_hsa030221.16678486
51Serotonergic synapse_Homo sapiens_hsa047261.14754271
52RNA degradation_Homo sapiens_hsa030181.13811063
53Protein digestion and absorption_Homo sapiens_hsa049741.11853145
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.11038120
55Cardiac muscle contraction_Homo sapiens_hsa042601.08247684
56Nicotine addiction_Homo sapiens_hsa050331.08155560
57Steroid biosynthesis_Homo sapiens_hsa001001.07812489
58Lysine degradation_Homo sapiens_hsa003101.07464545
59Sulfur relay system_Homo sapiens_hsa041221.06396646
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.06155196
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05519732
62Fanconi anemia pathway_Homo sapiens_hsa034601.03723295
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03639129
64Biosynthesis of amino acids_Homo sapiens_hsa012301.00538941
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99460642
66Oxidative phosphorylation_Homo sapiens_hsa001900.99388154
67Arginine and proline metabolism_Homo sapiens_hsa003300.98792391
68Chemical carcinogenesis_Homo sapiens_hsa052040.98746771
69Glutathione metabolism_Homo sapiens_hsa004800.97999424
70Salivary secretion_Homo sapiens_hsa049700.89241262
71ABC transporters_Homo sapiens_hsa020100.85961242
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82424940
73PPAR signaling pathway_Homo sapiens_hsa033200.80952893
74Long-term potentiation_Homo sapiens_hsa047200.80528903
75One carbon pool by folate_Homo sapiens_hsa006700.78287894
76Proteasome_Homo sapiens_hsa030500.77384904
77Ovarian steroidogenesis_Homo sapiens_hsa049130.76627017
78Arachidonic acid metabolism_Homo sapiens_hsa005900.76287977
79Fructose and mannose metabolism_Homo sapiens_hsa000510.74483702
80Circadian rhythm_Homo sapiens_hsa047100.73473108
81GABAergic synapse_Homo sapiens_hsa047270.72936910
82Retinol metabolism_Homo sapiens_hsa008300.71427441
83Glutamatergic synapse_Homo sapiens_hsa047240.71268345
84Homologous recombination_Homo sapiens_hsa034400.69724021
85Taste transduction_Homo sapiens_hsa047420.68854255
86Asthma_Homo sapiens_hsa053100.67776989
87Cocaine addiction_Homo sapiens_hsa050300.65148385
88Glycerolipid metabolism_Homo sapiens_hsa005610.65090598
89Primary immunodeficiency_Homo sapiens_hsa053400.64489294
90Fat digestion and absorption_Homo sapiens_hsa049750.63506191
91Type I diabetes mellitus_Homo sapiens_hsa049400.62515089
92Other glycan degradation_Homo sapiens_hsa005110.60285387
93Long-term depression_Homo sapiens_hsa047300.59696564
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58693253
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58341454
96Purine metabolism_Homo sapiens_hsa002300.57610533
97Parkinsons disease_Homo sapiens_hsa050120.57267062
98Pancreatic secretion_Homo sapiens_hsa049720.56323178
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.56000483
100Starch and sucrose metabolism_Homo sapiens_hsa005000.55576775
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54577887
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53660738
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53439324
104Alzheimers disease_Homo sapiens_hsa050100.52860107
105Insulin secretion_Homo sapiens_hsa049110.52670485
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52105563
107Fatty acid elongation_Homo sapiens_hsa000620.50542599
108Phenylalanine metabolism_Homo sapiens_hsa003600.47711012
109Circadian entrainment_Homo sapiens_hsa047130.46519061
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46512880
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45537781
112Inositol phosphate metabolism_Homo sapiens_hsa005620.43939679
113Lysosome_Homo sapiens_hsa041420.43930281
114Vibrio cholerae infection_Homo sapiens_hsa051100.43273119
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42409620
116Allograft rejection_Homo sapiens_hsa053300.42038072
117Rheumatoid arthritis_Homo sapiens_hsa053230.41590636
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41218887
119Morphine addiction_Homo sapiens_hsa050320.40065109
120Choline metabolism in cancer_Homo sapiens_hsa052310.38142585
121Oxytocin signaling pathway_Homo sapiens_hsa049210.37832025
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.37593646
123Cholinergic synapse_Homo sapiens_hsa047250.35856105
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.34972148
125Vitamin B6 metabolism_Homo sapiens_hsa007500.34696092
126Selenocompound metabolism_Homo sapiens_hsa004500.34394578
127Pentose phosphate pathway_Homo sapiens_hsa000300.34129668
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32689852
129cAMP signaling pathway_Homo sapiens_hsa040240.31632595
130Histidine metabolism_Homo sapiens_hsa003400.30185086
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29080854
132Renin secretion_Homo sapiens_hsa049240.28881278
133Metabolic pathways_Homo sapiens_hsa011000.28602239
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27994116
135Amphetamine addiction_Homo sapiens_hsa050310.26983903
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24463616
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24109107
138Huntingtons disease_Homo sapiens_hsa050160.21620215
139Glucagon signaling pathway_Homo sapiens_hsa049220.19740639
140Renin-angiotensin system_Homo sapiens_hsa046140.19078391
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.17678783
142Type II diabetes mellitus_Homo sapiens_hsa049300.17309492
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17247106
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16222125
145Dopaminergic synapse_Homo sapiens_hsa047280.15530023
146Calcium signaling pathway_Homo sapiens_hsa040200.15481472
147Gap junction_Homo sapiens_hsa045400.14896734
148Maturity onset diabetes of the young_Homo sapiens_hsa049500.12540003

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