AQP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chemical homeostasis within a tissue (GO:0048875)9.05560639
2axoneme assembly (GO:0035082)7.89966197
3primary alcohol catabolic process (GO:0034310)7.35460536
4left/right pattern formation (GO:0060972)7.17674392
5hemidesmosome assembly (GO:0031581)6.79478415
6sperm capacitation (GO:0048240)6.49034832
7regulation of cilium movement (GO:0003352)6.44863807
8vitamin transmembrane transport (GO:0035461)5.81206721
9microtubule bundle formation (GO:0001578)5.40577837
10pattern specification involved in kidney development (GO:0061004)5.38997596
11lung epithelium development (GO:0060428)5.38417265
12sperm motility (GO:0030317)5.27227169
13ventricular system development (GO:0021591)5.25699464
14left/right axis specification (GO:0070986)5.15732283
15centriole assembly (GO:0098534)5.08748912
16negative regulation of inclusion body assembly (GO:0090084)4.78531949
17lung lobe morphogenesis (GO:0060463)4.68390608
18microtubule depolymerization (GO:0007019)4.63986533
19cilium organization (GO:0044782)4.60581697
20mesodermal cell differentiation (GO:0048333)4.55089628
21pyrimidine-containing compound transmembrane transport (GO:0072531)4.54770510
22cilium assembly (GO:0042384)4.50720579
23terpenoid biosynthetic process (GO:0016114)4.50092986
244-hydroxyproline metabolic process (GO:0019471)4.43256869
25dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.37410899
26intraciliary transport (GO:0042073)4.32802633
27microtubule polymerization or depolymerization (GO:0031109)4.29860581
28regulation of interleukin-13 production (GO:0032656)4.28090597
29L-ascorbic acid metabolic process (GO:0019852)4.27962989
30tolerance induction (GO:0002507)4.25508078
31positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.23266366
32regulation of interleukin-5 production (GO:0032674)4.20231771
33xenobiotic catabolic process (GO:0042178)4.18736562
34retinoic acid metabolic process (GO:0042573)4.14652327
35retinol metabolic process (GO:0042572)4.12198741
36positive regulation of osteoblast proliferation (GO:0033690)4.08135236
37cell adhesion mediated by integrin (GO:0033627)4.05375286
38epithelial cell differentiation involved in prostate gland development (GO:0060742)3.90329671
39phosphatidylethanolamine biosynthetic process (GO:0006646)3.88725399
40establishment of apical/basal cell polarity (GO:0035089)3.87329108
41negative regulation of T cell differentiation in thymus (GO:0033085)3.87133468
42regulation of microtubule-based movement (GO:0060632)3.86895113
43establishment of planar polarity (GO:0001736)3.83928962
44establishment of tissue polarity (GO:0007164)3.83928962
45regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.81111843
46acrosome reaction (GO:0007340)3.77607111
47primary alcohol metabolic process (GO:0034308)3.74652976
48bundle of His cell to Purkinje myocyte communication (GO:0086069)3.73001749
49peptidyl-proline hydroxylation (GO:0019511)3.72599670
50ethanol oxidation (GO:0006069)3.71963387
51fusion of sperm to egg plasma membrane (GO:0007342)3.71056068
52O-glycan processing (GO:0016266)3.66485861
53negative regulation of humoral immune response (GO:0002921)3.61307338
54regulation of skeletal muscle contraction (GO:0014819)3.60951382
55cytoplasmic microtubule organization (GO:0031122)3.58999761
56branching involved in salivary gland morphogenesis (GO:0060445)3.57699604
57microtubule-based movement (GO:0007018)3.57342796
58positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.56177862
59negative regulation of immunoglobulin mediated immune response (GO:0002890)3.53199586
60negative regulation of B cell mediated immunity (GO:0002713)3.53199586
61positive regulation of tolerance induction (GO:0002645)3.52811146
62cellular component assembly involved in morphogenesis (GO:0010927)3.51449664
63response to xenobiotic stimulus (GO:0009410)3.51212350
64calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.49452972
65phosphatidylethanolamine metabolic process (GO:0046337)3.49207125
66spermatid development (GO:0007286)3.48590221
67cell projection assembly (GO:0030031)3.43219849
68positive regulation of endothelial cell differentiation (GO:0045603)3.38439381
69diterpenoid biosynthetic process (GO:0016102)3.32478973
70epithelial cell-cell adhesion (GO:0090136)3.30710948
71epithelial tube branching involved in lung morphogenesis (GO:0060441)3.27618381
72citrulline biosynthetic process (GO:0019240)3.27574629
73establishment or maintenance of monopolar cell polarity (GO:0061339)3.27327501
74establishment of monopolar cell polarity (GO:0061162)3.27327501
75hypotonic response (GO:0006971)3.25256317
76regulation of germinal center formation (GO:0002634)3.21140433
77desmosome organization (GO:0002934)3.20150404
78tight junction assembly (GO:0070830)3.19940928
79multicellular organismal water homeostasis (GO:0050891)3.19396571
80regulation of hippo signaling (GO:0035330)3.18996853
81protein localization to cilium (GO:0061512)3.16683521
82regulation of cardioblast differentiation (GO:0051890)3.15467405
83negative regulation of fatty acid transport (GO:2000192)3.14462012
84establishment of skin barrier (GO:0061436)3.12778505
85regulation of vasculogenesis (GO:2001212)3.12415541
86type B pancreatic cell proliferation (GO:0044342)3.12402607
87regulation of inclusion body assembly (GO:0090083)3.11673421
88cytoskeletal anchoring at plasma membrane (GO:0007016)3.09217908
89protein hydroxylation (GO:0018126)3.07782254
90growth hormone receptor signaling pathway (GO:0060396)3.04923246
91cell-substrate junction assembly (GO:0007044)3.04598526
92regulation of endothelial cell differentiation (GO:0045601)3.01858793
93endothelial tube morphogenesis (GO:0061154)3.01382520
94morphogenesis of an endothelium (GO:0003159)3.01382520
95polarized epithelial cell differentiation (GO:0030859)3.00943862
96negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.00856250
97regulation of cilium assembly (GO:1902017)3.00700641
98ethanol metabolic process (GO:0006067)2.98805910
99interferon-gamma secretion (GO:0072643)2.97227874
100* one-carbon compound transport (GO:0019755)2.96045259
101response to nitrosative stress (GO:0051409)2.92993367
102glutathione derivative biosynthetic process (GO:1901687)2.88848449
103glutathione derivative metabolic process (GO:1901685)2.88848449
104renal system development (GO:0072001)2.87779769
105regulation of glomerular filtration (GO:0003093)2.87663037
106regulation of water loss via skin (GO:0033561)2.86965463
107peptide catabolic process (GO:0043171)2.85471821
108cilium morphogenesis (GO:0060271)2.84936904
109ear development (GO:0043583)2.84276320
110negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.84000974
111negative regulation of cell fate specification (GO:0009996)2.83029556
112centriole replication (GO:0007099)2.79499028
113positive regulation of smoothened signaling pathway (GO:0045880)2.79296959
114embryonic camera-type eye development (GO:0031076)2.77907063
115multicellular organism reproduction (GO:0032504)2.76927931
116microtubule severing (GO:0051013)2.76043684
117gland morphogenesis (GO:0022612)2.74090768
118planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72097328
119lung vasculature development (GO:0060426)2.71885304
120endocardial cushion development (GO:0003197)2.71381506
121hormone catabolic process (GO:0042447)2.71273416
122lung-associated mesenchyme development (GO:0060484)2.70991007
123glomerular epithelial cell development (GO:0072310)2.70952103
124progesterone metabolic process (GO:0042448)2.68404841
125phosphatidylcholine biosynthetic process (GO:0006656)2.67796025
126retina vasculature morphogenesis in camera-type eye (GO:0061299)2.67793347
127hair cycle (GO:0042633)2.67740759
128molting cycle (GO:0042303)2.67740759
129protein localization to endosome (GO:0036010)2.67448390
130water homeostasis (GO:0030104)2.67325076
131lung alveolus development (GO:0048286)2.66274057
132plasma membrane fusion (GO:0045026)2.65652795
133regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.65291949
134cellular response to arsenic-containing substance (GO:0071243)2.65268080
135nucleoside diphosphate phosphorylation (GO:0006165)2.63036212
136endodermal cell differentiation (GO:0035987)2.62753734
137regulation of osteoblast proliferation (GO:0033688)2.62554118
138positive regulation of steroid biosynthetic process (GO:0010893)2.62098030
139apoptotic cell clearance (GO:0043277)2.61458478
140reproduction (GO:0000003)2.61001318
141polyol transport (GO:0015791)2.60948692
142renal filtration (GO:0097205)2.59974705
143regulation of cholesterol biosynthetic process (GO:0045540)2.59933130
144regulation of tolerance induction (GO:0002643)2.59902451
145renal system process involved in regulation of blood volume (GO:0001977)2.58835746
146regulation of cell fate specification (GO:0042659)2.58317011
147single fertilization (GO:0007338)2.57478199
148hydrogen peroxide biosynthetic process (GO:0050665)2.57202869
149glutathione biosynthetic process (GO:0006750)2.57108799
150exogenous drug catabolic process (GO:0042738)2.56189989
151negative regulation of chondrocyte differentiation (GO:0032331)2.55690937
152regulation of integrin-mediated signaling pathway (GO:2001044)2.55626844
153chromosome condensation (GO:0030261)2.55471609
154sexual reproduction (GO:0019953)2.55321171
155renal absorption (GO:0070293)2.54278343
156cellular response to growth hormone stimulus (GO:0071378)2.53716381
157hippo signaling (GO:0035329)2.53712673
158induction of positive chemotaxis (GO:0050930)2.53179677
159ectoderm development (GO:0007398)2.51915750
160establishment of epithelial cell polarity (GO:0090162)2.51635720
161negative regulation of smooth muscle cell migration (GO:0014912)2.50097094
162respiratory tube development (GO:0030323)2.50020624
163cell-cell junction assembly (GO:0007043)2.44134384
164positive regulation of p38MAPK cascade (GO:1900745)2.44024697
165segment specification (GO:0007379)2.43111735
166embryonic foregut morphogenesis (GO:0048617)2.42774661
167protein targeting to plasma membrane (GO:0072661)2.42399695
168positive regulation of positive chemotaxis (GO:0050927)2.41908108
169tissue remodeling (GO:0048771)2.41784745
170cellular response to nitric oxide (GO:0071732)2.39679473
171regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.38289739
172positive regulation of hormone biosynthetic process (GO:0046886)2.37373765
173negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.36925357
174response to vitamin A (GO:0033189)2.36423503
175axonemal dynein complex assembly (GO:0070286)18.3850322
176cilium or flagellum-dependent cell motility (GO:0001539)14.0546457
177motile cilium assembly (GO:0044458)13.2298165
178cilium movement (GO:0003341)12.1520687
179surfactant homeostasis (GO:0043129)11.2034050
180epithelial cilium movement (GO:0003351)10.8497259
181epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.1349159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.75258878
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.76739947
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.68305832
4* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.65125929
5* TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.61174909
6ZNF263_19887448_ChIP-Seq_K562_Human3.23362065
7ESR2_21235772_ChIP-Seq_MCF-7_Human3.22566712
8ESR1_21235772_ChIP-Seq_MCF-7_Human3.06110028
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.03170544
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.96312653
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76304018
12DROSHA_22980978_ChIP-Seq_HELA_Human2.45413051
13CLOCK_20551151_ChIP-Seq_293T_Human2.44120907
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.43515744
15SMC4_20622854_ChIP-Seq_HELA_Human2.28597061
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.21465370
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20499540
18* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.12650560
19ZNF217_24962896_ChIP-Seq_MCF-7_Human2.12092819
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.09461490
21* SOX2_20726797_ChIP-Seq_SW620_Human2.08873110
22PPAR_26484153_Chip-Seq_NCI-H1993_Human2.07882992
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04867557
24TP63_22573176_ChIP-Seq_HFKS_Human2.01345980
25CTCF_27219007_Chip-Seq_Bcells_Human1.94906467
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89619382
27* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.89152729
28AHR_22903824_ChIP-Seq_MCF-7_Human1.88597921
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87919670
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.87519834
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.87519834
32SOX9_24532713_ChIP-Seq_HFSC_Mouse1.80508719
33CDX2_20551321_ChIP-Seq_CACO-2_Human1.78971151
34P68_20966046_ChIP-Seq_HELA_Human1.78772863
35ELF1_20517297_ChIP-Seq_JURKAT_Human1.76999573
36* RACK7_27058665_Chip-Seq_MCF-7_Human1.76968954
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.76390885
38SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.73927591
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71475258
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.69059705
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.67364714
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.66324541
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.65425704
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57672141
45GATA4_25053715_ChIP-Seq_YYC3_Human1.55601771
46CTCF_20526341_ChIP-Seq_ESCs_Human1.54972162
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.54622194
48CJUN_26792858_Chip-Seq_BT549_Human1.53112143
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51303231
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.50360661
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.50048603
52CREB1_26743006_Chip-Seq_LNCaP_Human1.49837138
53BCOR_27268052_Chip-Seq_Bcells_Human1.49370614
54KLF5_25053715_ChIP-Seq_YYC3_Human1.48515490
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.48390469
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46509921
57PHF8_20622854_ChIP-Seq_HELA_Human1.40484316
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39034842
59BCL6_27268052_Chip-Seq_Bcells_Human1.38998320
60STAT1_20625510_ChIP-Seq_HELA_Human1.37753561
61* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37698240
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37205302
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.37192067
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.36301220
65GATA1_19941826_ChIP-Seq_K562_Human1.36210544
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36006688
67SA1_27219007_Chip-Seq_Bcells_Human1.32901979
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.30325791
69P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.30205193
70GATA6_25053715_ChIP-Seq_YYC3_Human1.29647391
71E2F1_20622854_ChIP-Seq_HELA_Human1.28607998
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28180948
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28180948
74* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.27459131
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26983323
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26255845
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25798453
78GATA3_24758297_ChIP-Seq_MCF-7_Human1.25663749
79TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23955964
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23491651
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23157222
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22920084
83* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21610249
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18840333
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18434360
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.18378965
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18306389
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17804217
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.17498324
90GATA1_22025678_ChIP-Seq_K562_Human1.17073761
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.16986631
92LXR_22158963_ChIP-Seq_LIVER_Mouse1.16536148
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15946386
94TBX20_22080862_ChIP-Seq_HEART_Mouse1.15193940
95TBX20_22328084_ChIP-Seq_HEART_Mouse1.15193940
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14166404
97ATF3_27146783_Chip-Seq_COLON_Human1.13559699
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.13080238
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11920526
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11310289
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11014182
102P300_27268052_Chip-Seq_Bcells_Human1.10602725
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09000183
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07815940
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07446813
106KDM2B_26808549_Chip-Seq_K562_Human1.06763382
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06645835
108CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.06048508
109* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05723537
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04198524
111EZH2_27294783_Chip-Seq_ESCs_Mouse1.04106220
112FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03763306
113HNFA_21074721_ChIP-Seq_CACO-2_Human1.02182526
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02170921
115ETV1_20927104_ChIP-Seq_GIST48_Human1.01139060
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99291552
117* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99217078
118RXR_22158963_ChIP-Seq_LIVER_Mouse0.99123692
119TP53_22127205_ChIP-Seq_IMR90_Human0.98754518
120TP53_18474530_ChIP-ChIP_U2OS_Human0.98691553
121RBPJ_21746931_ChIP-Seq_IB4_Human0.97736193
122PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96843185
123SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96653454
124GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96596344
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96480854
126LXR_22292898_ChIP-Seq_THP-1_Human0.96390570
127ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96346764
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96143987
129* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95876874
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.95687630
131EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94926724
132TP63_23658742_ChIP-Seq_EP156T_Human0.94742644
133CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94109184
134GATA6_21074721_ChIP-Seq_CACO-2_Human0.93350654
135KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93027780
136SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92875863
137TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92845342
138PHF8_20622853_ChIP-Seq_HELA_Human0.92416119
139PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.91883312
140CEBPB_22108803_ChIP-Seq_LS180_Human0.91463711
141FOXA2_19822575_ChIP-Seq_HepG2_Human0.90871354
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90756152
143NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90348099
144FOXA1_25552417_ChIP-Seq_VCAP_Human0.89826296
145ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89337459
146ERA_21632823_ChIP-Seq_H3396_Human0.89061523
147CBX2_22325352_ChIP-Seq_293T-Rex_Human0.87971238
148FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87310964
149ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86340879
150* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85330629
151FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83840569
152POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83647513
153CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81138777
154WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79265663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog4.95165587
2MP0010234_abnormal_vibrissa_follicle4.93645276
3MP0003878_abnormal_ear_physiology3.99131234
4MP0005377_hearing/vestibular/ear_phenot3.99131234
5MP0001958_emphysema3.94911090
6MP0002653_abnormal_ependyma_morphology3.63313036
7MP0005410_abnormal_fertilization3.13713698
8MP0002254_reproductive_system_inflammat2.95721349
9MP0004043_abnormal_pH_regulation2.92587524
10MP0003566_abnormal_cell_adhesion2.91232188
11MP0005083_abnormal_biliary_tract2.81247085
12MP0005248_abnormal_Harderian_gland2.67035245
13MP0008875_abnormal_xenobiotic_pharmacok2.65868560
14MP0008004_abnormal_stomach_pH2.57163181
15MP0000566_synostosis2.53506354
16MP0004272_abnormal_basement_membrane2.47551210
17MP0000537_abnormal_urethra_morphology2.38672817
18MP0002138_abnormal_hepatobiliary_system2.37757600
19MP0001849_ear_inflammation2.30890007
20MP0002249_abnormal_larynx_morphology2.17964641
21MP0010368_abnormal_lymphatic_system2.15245076
22MP0006054_spinal_hemorrhage2.14000621
23MP0004019_abnormal_vitamin_homeostasis2.12148841
24MP0008995_early_reproductive_senescence2.06825298
25MP0004133_heterotaxia1.98594955
26MP0005275_abnormal_skin_tensile1.97938837
27MP0010678_abnormal_skin_adnexa1.97471627
28MP0001984_abnormal_olfaction1.95396094
29MP0004264_abnormal_extraembryonic_tissu1.92752360
30MP0002909_abnormal_adrenal_gland1.87599942
31MP0002277_abnormal_respiratory_mucosa1.86911973
32MP0005388_respiratory_system_phenotype1.84294436
33MP0002133_abnormal_respiratory_system1.84294436
34MP0001177_atelectasis1.79757645
35MP0001765_abnormal_ion_homeostasis1.76330112
36MP0000762_abnormal_tongue_morphology1.70872604
37MP0002796_impaired_skin_barrier1.69201513
38MP0003705_abnormal_hypodermis_morpholog1.69041184
39MP0003453_abnormal_keratinocyte_physiol1.67710674
40MP0005670_abnormal_white_adipose1.59653749
41MP0010030_abnormal_orbit_morphology1.57227450
42MP0002098_abnormal_vibrissa_morphology1.56882951
43MP0002295_abnormal_pulmonary_circulatio1.55995099
44MP0003698_abnormal_male_reproductive1.55418044
45MP0002877_abnormal_melanocyte_morpholog1.55193373
46MP0010352_gastrointestinal_tract_polyps1.53090088
47MP0001346_abnormal_lacrimal_gland1.52195071
48MP0001879_abnormal_lymphatic_vessel1.51873206
49MP0005023_abnormal_wound_healing1.51249101
50MP0002234_abnormal_pharynx_morphology1.50928873
51MP0000627_abnormal_mammary_gland1.50610222
52MP0009379_abnormal_foot_pigmentation1.48379792
53MP0001881_abnormal_mammary_gland1.46921292
54MP0001929_abnormal_gametogenesis1.36977146
55MP0004084_abnormal_cardiac_muscle1.35533862
56MP0002060_abnormal_skin_morphology1.28996045
57MP0008438_abnormal_cutaneous_collagen1.28682798
58MP0005164_abnormal_response_to1.25916641
59MP0000534_abnormal_ureter_morphology1.24631773
60MP0004883_abnormal_blood_vessel1.23266824
61MP0005167_abnormal_blood-brain_barrier1.23077065
62MP0009384_cardiac_valve_regurgitation1.22712130
63MP0000383_abnormal_hair_follicle1.21898286
64MP0000467_abnormal_esophagus_morphology1.20098976
65MP0004947_skin_inflammation1.18708404
66MP0005310_abnormal_salivary_gland1.17634413
67MP0005165_increased_susceptibility_to1.16856666
68MP0002282_abnormal_trachea_morphology1.15253872
69MP0003300_gastrointestinal_ulcer1.15094086
70MP0003115_abnormal_respiratory_system1.12364939
71MP0010155_abnormal_intestine_physiology1.08541621
72MP0005408_hypopigmentation1.08150247
73MP0003191_abnormal_cellular_cholesterol1.07453139
74MP0002132_abnormal_respiratory_system1.06107319
75MP0005395_other_phenotype1.05555982
76MP0009780_abnormal_chondrocyte_physiolo1.05215602
77MP0003806_abnormal_nucleotide_metabolis1.00043438
78MP0000858_altered_metastatic_potential1.00041005
79MP0005409_darkened_coat_color0.98834694
80MP0003091_abnormal_cell_migration0.98831726
81MP0001216_abnormal_epidermal_layer0.98073957
82MP0000579_abnormal_nail_morphology0.96879045
83MP0000465_gastrointestinal_hemorrhage0.94342202
84MP0008789_abnormal_olfactory_epithelium0.93524431
85MP0001485_abnormal_pinna_reflex0.91814262
86MP0003045_fibrosis0.91635685
87MP0003186_abnormal_redox_activity0.90716938
88MP0005636_abnormal_mineral_homeostasis0.89918458
89MP0001175_abnormal_lung_morphology0.88846008
90MP0005501_abnormal_skin_physiology0.88371938
91MP0000767_abnormal_smooth_muscle0.84618240
92MP0002160_abnormal_reproductive_system0.83869768
93MP0003448_altered_tumor_morphology0.83521655
94MP0005197_abnormal_uvea_morphology0.82916077
95MP0002161_abnormal_fertility/fecundity0.82767365
96MP0005623_abnormal_meninges_morphology0.81451522
97MP0002233_abnormal_nose_morphology0.80706695
98MP0001270_distended_abdomen0.80110955
99MP0003303_peritoneal_inflammation0.79630814
100MP0000750_abnormal_muscle_regeneration0.78511329
101MP0003279_aneurysm0.78381382
102MP0009643_abnormal_urine_homeostasis0.77231577
103MP0000249_abnormal_blood_vessel0.76254363
104MP0002136_abnormal_kidney_physiology0.76000865
105MP0003942_abnormal_urinary_system0.75702598
106MP0001851_eye_inflammation0.75513863
107MP0004885_abnormal_endolymph0.75350565
108MP0002168_other_aberrant_phenotype0.74437929
109MP0000462_abnormal_digestive_system0.74214037
110MP0003656_abnormal_erythrocyte_physiolo0.73829088
111MP0003075_altered_response_to0.73517497
112MP0005394_taste/olfaction_phenotype0.73102006
113MP0005499_abnormal_olfactory_system0.73102006
114MP0000678_abnormal_parathyroid_gland0.72838074
115MP0003724_increased_susceptibility_to0.72635144
116MP0005076_abnormal_cell_differentiation0.72272524
117MP0000377_abnormal_hair_follicle0.71917320
118MP0002925_abnormal_cardiovascular_devel0.71255948
119MP0001188_hyperpigmentation0.70870950
120MP0010771_integument_phenotype0.70834804
121MP0004381_abnormal_hair_follicle0.69495343
122MP0000613_abnormal_salivary_gland0.69230719
123MP0009053_abnormal_anal_canal0.68312253
124MP0002896_abnormal_bone_mineralization0.67946233
125MP0000026_abnormal_inner_ear0.67897189
126MP0001664_abnormal_digestion0.67116806
127MP0005166_decreased_susceptibility_to0.66919819
128MP0000343_altered_response_to0.66574073
129MP0004858_abnormal_nervous_system0.65530164
130MP0000647_abnormal_sebaceous_gland0.65294557
131MP0000733_abnormal_muscle_development0.64608691
132MP0002139_abnormal_hepatobiliary_system0.61956859
133MP0000681_abnormal_thyroid_gland0.61920590
134MP0001614_abnormal_blood_vessel0.61558142
135MP0005365_abnormal_bile_salt0.60142911
136MP0001502_abnormal_circadian_rhythm0.59988653
137MP0000049_abnormal_middle_ear0.58735641
138MP0001666_abnormal_nutrient_absorption0.54715255
139MP0001348_abnormal_lacrimal_gland0.52357096
140MP0003866_abnormal_defecation0.51463113
141MP0005508_abnormal_skeleton_morphology0.49474382
142MP0001663_abnormal_digestive_system0.46054718
143MP0000367_abnormal_coat/_hair0.44206823
144MP0002735_abnormal_chemical_nociception0.42652258
145MP0005666_abnormal_adipose_tissue0.40473131

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.88037046
2Rhinitis (HP:0012384)9.44673562
3Interstitial pulmonary disease (HP:0006530)8.20681093
4Bronchiectasis (HP:0002110)6.93095109
5Onycholysis (HP:0001806)6.44373559
6Milia (HP:0001056)5.24737443
7Atrophic scars (HP:0001075)5.14327722
8Right ventricular cardiomyopathy (HP:0011663)4.95875412
9Fragile nails (HP:0001808)4.76221874
10Hyperactive renin-angiotensin system (HP:0000841)4.67875736
11Stomach cancer (HP:0012126)4.53415023
12Infertility (HP:0000789)4.30836173
13Male infertility (HP:0003251)4.20677498
14Bronchomalacia (HP:0002780)4.11980114
15Chronic bronchitis (HP:0004469)3.95892590
16Renal salt wasting (HP:0000127)3.92058105
17Ulnar bowing (HP:0003031)3.88388163
18Tubulointerstitial fibrosis (HP:0005576)3.83666228
19Humeroradial synostosis (HP:0003041)3.73540402
20Synostosis involving the elbow (HP:0003938)3.73540402
21Recurrent sinusitis (HP:0011108)3.72722383
22Chronic sinusitis (HP:0011109)3.72548129
23Arterial tortuosity (HP:0005116)3.71044434
24Recurrent otitis media (HP:0000403)3.59035753
25Gout (HP:0001997)3.55478294
26Vascular tortuosity (HP:0004948)3.48973027
27Polycythemia (HP:0001901)3.42453279
28Occipital encephalocele (HP:0002085)3.25242393
29Atelectasis (HP:0100750)3.20188350
30Plantar hyperkeratosis (HP:0007556)3.04428386
31Abnormality of the nasal mucosa (HP:0000433)3.03182865
32Bowing of the arm (HP:0006488)3.02366209
33Bowed forearm bones (HP:0003956)3.02366209
34Broad metatarsal (HP:0001783)2.97388601
35Bell-shaped thorax (HP:0001591)2.97096191
36Respiratory distress (HP:0002098)2.88911112
37Hyperkalemia (HP:0002153)2.86879116
38Tachypnea (HP:0002789)2.80000711
39Hematochezia (HP:0002573)2.78066769
40Shallow orbits (HP:0000586)2.78045957
41Glomerulosclerosis (HP:0000096)2.73705136
42Chronic otitis media (HP:0000389)2.69530612
43Hypoplasia of dental enamel (HP:0006297)2.64659563
44Cerebral aneurysm (HP:0004944)2.64594489
45Curly hair (HP:0002212)2.55442483
46Pustule (HP:0200039)2.52475436
47Subacute progressive viral hepatitis (HP:0006572)2.48845533
48Pili torti (HP:0003777)2.46587574
49True hermaphroditism (HP:0010459)2.46341419
50Tubulointerstitial nephritis (HP:0001970)2.45511143
51Pancreatic fibrosis (HP:0100732)2.44009610
52Cystic liver disease (HP:0006706)2.42222487
53Aortic dissection (HP:0002647)2.39363126
54Nail dystrophy (HP:0008404)2.33386812
55Ependymoma (HP:0002888)2.29359069
56Vascular calcification (HP:0004934)2.29114770
57Ankle contracture (HP:0006466)2.27488071
58Aortic aneurysm (HP:0004942)2.25138887
59Osteolytic defects of the hand bones (HP:0009699)2.24111678
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.24111678
61Nephronophthisis (HP:0000090)2.21716865
62Cardiovascular calcification (HP:0011915)2.21014153
63Chronic hepatic failure (HP:0100626)2.20288262
64Abnormality of chloride homeostasis (HP:0011422)2.19834527
65Turricephaly (HP:0000262)2.18580256
66Esophageal varix (HP:0002040)2.14789571
67Micronodular cirrhosis (HP:0001413)2.13446114
68Nasal polyposis (HP:0100582)2.10606160
69Focal segmental glomerulosclerosis (HP:0000097)2.09435295
70Buphthalmos (HP:0000557)2.09096460
71Esophageal atresia (HP:0002032)2.08171201
72Upper limb amyotrophy (HP:0009129)2.06374366
73Distal upper limb amyotrophy (HP:0007149)2.06374366
74Hyperaldosteronism (HP:0000859)2.05860838
75Tarsal synostosis (HP:0008368)2.04034729
76Abnormal hemoglobin (HP:0011902)2.03628035
77Woolly hair (HP:0002224)2.02585722
78Alveolar cell carcinoma (HP:0006519)2.01863656
79Visceral angiomatosis (HP:0100761)2.00608680
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.6551550
81Abnormal respiratory epithelium morphology (HP:0012253)10.3697658
82Abnormal respiratory motile cilium morphology (HP:0005938)10.3697658
83Abnormal respiratory motile cilium physiology (HP:0012261)10.2659000
84Absent/shortened dynein arms (HP:0200106)10.1734918
85Dynein arm defect of respiratory motile cilia (HP:0012255)10.1734918
86Abnormality of the gastric mucosa (HP:0004295)1.99966068
87Neurofibrillary tangles (HP:0002185)1.99560248
88Germ cell neoplasia (HP:0100728)1.99025294
89Alopecia of scalp (HP:0002293)1.97898012
90Tubular atrophy (HP:0000092)1.95409409
91Tubulointerstitial abnormality (HP:0001969)1.94583222
92Long toe (HP:0010511)1.93984231
93Progressive sensorineural hearing impairment (HP:0000408)1.93728986
94Biliary tract neoplasm (HP:0100574)1.93637797
95Hypotension (HP:0002615)1.92773200
96Bifid scrotum (HP:0000048)1.91347590
97Labial hypoplasia (HP:0000066)1.88993653
98Rectal prolapse (HP:0002035)1.87624332
99Abnormality of the renal medulla (HP:0100957)1.87618031
100Abnormality of renin-angiotensin system (HP:0000847)1.86562795
101Postaxial foot polydactyly (HP:0001830)1.85926225
102Molar tooth sign on MRI (HP:0002419)1.85760217
103Abnormality of midbrain morphology (HP:0002418)1.85760217
104Aneurysm (HP:0002617)1.85495752
105Flat acetabular roof (HP:0003180)1.84469879
106Pancreatic cysts (HP:0001737)1.84302871
107Aplasia involving bones of the extremities (HP:0009825)1.83360466
108Aplasia involving bones of the upper limbs (HP:0009823)1.83360466
109Aplasia of the phalanges of the hand (HP:0009802)1.83360466
110Femoral bowing (HP:0002980)1.82795806
111Hemangiomatosis (HP:0007461)1.81814302
112Fragile skin (HP:0001030)1.81806622
113Blepharitis (HP:0000498)1.81496007
114* Abnormal blistering of the skin (HP:0008066)1.81175675
115Hand muscle atrophy (HP:0009130)1.80769442
116Short hallux (HP:0010109)1.80568606
117Mildly elevated creatine phosphokinase (HP:0008180)1.80106280
118Neoplasm of the tracheobronchial system (HP:0100552)1.79278151
119Cerebral inclusion bodies (HP:0100314)1.78731268
120Decreased circulating renin level (HP:0003351)1.78431039
121Renal tubular acidosis (HP:0001947)1.78052526
122Radial bowing (HP:0002986)1.76667133
123Obstructive sleep apnea (HP:0002870)1.76480759
124Astrocytoma (HP:0009592)1.75636275
125Abnormality of the astrocytes (HP:0100707)1.75636275
126Abnormality of the middle phalanges of the toes (HP:0010183)1.75393757
127Hemorrhage of the eye (HP:0011885)1.74324992
128Synostosis involving bones of the feet (HP:0009140)1.73917152
129Synostosis involving bones of the lower limbs (HP:0009138)1.73917152
130Urethral obstruction (HP:0000796)1.73166954
131Abnormality of the distal phalanges of the toes (HP:0010182)1.71645455
132Glucose intolerance (HP:0000833)1.69659203
133Bronchitis (HP:0012387)1.69517866
134Pterygium (HP:0001059)1.69319470
135Abnormality of permanent molar morphology (HP:0011071)1.68170099
136Abnormality of the dental root (HP:0006486)1.68170099
137Taurodontia (HP:0000679)1.68170099
138Stage 5 chronic kidney disease (HP:0003774)1.61506695
139Hyponatremia (HP:0002902)1.60474683
140Absent frontal sinuses (HP:0002688)1.58980399
141Congenital hepatic fibrosis (HP:0002612)1.58265674
142Short nail (HP:0001799)1.56850447
143Abnormality of molar morphology (HP:0011070)1.54308964
144Abnormality of molar (HP:0011077)1.54308964
145Cone-rod dystrophy (HP:0000548)1.52911532
146Abnormality of the dental pulp (HP:0006479)1.51680042
147Nephropathy (HP:0000112)1.51347639
148Popliteal pterygium (HP:0009756)1.48665194
149Anencephaly (HP:0002323)1.46079317
150Lip pit (HP:0100267)1.45928815
151Distal lower limb muscle weakness (HP:0009053)1.44469148
152Male pseudohermaphroditism (HP:0000037)1.43497933
153Recurrent bronchitis (HP:0002837)1.39597729
154Furrowed tongue (HP:0000221)1.38520769
155Stridor (HP:0010307)1.33758526
156Aplasia/Hypoplasia of the spleen (HP:0010451)1.33213021
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.33125749
158Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.29789744
159Short femoral neck (HP:0100864)1.29056688
160Asplenia (HP:0001746)1.27364624
161Median cleft lip (HP:0000161)1.27133481
162Abnormality of sodium homeostasis (HP:0010931)1.26392375
163Abnormality of macular pigmentation (HP:0008002)1.26159982
164Hypokalemic alkalosis (HP:0001949)1.26100036
165Short thorax (HP:0010306)1.24828260
166Severe visual impairment (HP:0001141)1.21548215
167Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.19464980
168Sclerocornea (HP:0000647)1.18704038
169Fetal akinesia sequence (HP:0001989)1.14160762
170Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.13490795
171Abnormality of monocarboxylic acid metabolism (HP:0010996)1.13193962
172Recurrent corneal erosions (HP:0000495)1.12127742
173Abnormal vertebral ossification (HP:0100569)1.11367548
174Down-sloping shoulders (HP:0200021)1.11276731
175Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.10576035
176Spinal muscular atrophy (HP:0007269)1.09328999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.12456771
2MATK4.02620280
3EPHB12.74921503
4MST42.61439600
5FER2.61412844
6EPHB22.58787528
7TGFBR22.40801642
8TRIB32.36175722
9SIK12.27350725
10SMG12.24391707
11LRRK22.23974625
12MAP3K22.21716912
13RIPK12.09018989
14LATS12.04722532
15PAK42.02684907
16MST1R1.93114618
17TRPM71.92142804
18EPHA31.87321535
19PKN21.81304727
20ERBB31.70818028
21PTK61.69544735
22ERN11.68878823
23NME11.65465053
24ERBB21.63222231
25PTK21.58057922
26TIE11.58004356
27FGFR21.57393788
28MAP3K31.52138761
29TESK11.38933888
30ICK1.38550876
31ZAP701.37971147
32WNK41.35486100
33BMX1.29416025
34PDGFRB1.29093607
35MARK21.26471406
36STK241.24274598
37MET1.19449614
38STK101.16301745
39NEK61.16114502
40TTN1.16068476
41STK391.14815112
42FGFR41.14239988
43DAPK21.10429338
44PDGFRA1.04451822
45PTK2B1.00998950
46MUSK1.00971659
47PLK41.00355343
48FGFR10.96900091
49CDK60.95873146
50MAP3K90.94180372
51FRK0.93561323
52ILK0.93405924
53FGFR30.92728595
54LMTK20.91485124
55STK30.90221943
56MAP2K10.84574612
57RPS6KB20.84406834
58EGFR0.82484193
59DDR20.79526077
60KSR20.79355222
61MAP2K20.78046601
62RET0.74432982
63MYLK0.73367647
64MAP3K10.71107077
65PRKD10.69167482
66MAP2K30.66156215
67LIMK10.63389502
68STK38L0.63187088
69PNCK0.61094707
70PRKD30.60488012
71PAK30.60345436
72TTK0.58824370
73NTRK10.58502013
74LATS20.55476533
75CAMK1D0.55219490
76MAP3K60.55193167
77NEK90.53011082
78TLK10.50640724
79MAPK150.50119186
80RPS6KA20.49739935
81MAP3K70.48420038
82GSK3A0.47895454
83MAPKAPK30.47659485
84TAOK10.47553255
85CDC42BPA0.47212198
86PIK3CA0.46807367
87EEF2K0.46473377
88CAMK1G0.46306438
89DMPK0.46220397
90CDK120.45195695
91NME20.44412972
92MAP3K110.43825029
93ROCK20.43629486
94DYRK1B0.42958331
95GRK60.42460897
96HIPK20.41460862
97SRC0.41433987
98PDK10.41243785
99CSK0.40954109
100INSRR0.40566226
101TGFBR10.39872565
102NLK0.38510979
103PDPK10.36639973
104ABL10.35086726
105PRKAA20.35032170
106CHUK0.34795316
107IGF1R0.33018550
108CAMK2G0.32981151
109ABL20.32706828
110RPS6KA40.31215910
111RIPK40.31004125
112STK380.31001309
113CDK80.30844981
114TYRO30.30492395
115ROCK10.30356589
116PAK20.29819656
117PRKCD0.28969294
118PRKCI0.28719335
119PRKCE0.28389145
120WNK10.28237500
121GRK10.27745593
122TYK20.27181967
123FYN0.25431420
124PRKD20.24698269
125MTOR0.24676991
126SGK10.24260440
127JAK10.23823439
128DAPK30.23550178
129TBK10.23422747
130INSR0.23402324
131MAP2K60.23041173
132IRAK30.22763648
133IRAK10.22061659
134CDK70.21209269
135PRKG20.20377417
136PAK10.19637244
137AURKA0.19246778
138RPS6KC10.18706626
139RPS6KL10.18706626
140PRKCQ0.18689467
141PBK0.16228076
142CAMKK10.16173622
143PRKCZ0.15885139
144MAP3K80.15729919
145PHKG10.15390055
146PHKG20.15390055
147ARAF0.15089517

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.38820162
2Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.14310693
3Chemical carcinogenesis_Homo sapiens_hsa052042.79326966
4Adherens junction_Homo sapiens_hsa045202.76522149
5ECM-receptor interaction_Homo sapiens_hsa045122.68900793
6Glutathione metabolism_Homo sapiens_hsa004802.26132899
7Bladder cancer_Homo sapiens_hsa052192.20289420
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.05826936
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90764139
10Tight junction_Homo sapiens_hsa045301.85457272
11Focal adhesion_Homo sapiens_hsa045101.85343944
12Vibrio cholerae infection_Homo sapiens_hsa051101.83800790
13Amoebiasis_Homo sapiens_hsa051461.71332224
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.66919088
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65655722
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60990588
17Small cell lung cancer_Homo sapiens_hsa052221.59879541
18Proteoglycans in cancer_Homo sapiens_hsa052051.57960914
19Histidine metabolism_Homo sapiens_hsa003401.55874869
20Caffeine metabolism_Homo sapiens_hsa002321.55623267
21Pancreatic cancer_Homo sapiens_hsa052121.53088310
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52148133
23Linoleic acid metabolism_Homo sapiens_hsa005911.48979421
24Sphingolipid metabolism_Homo sapiens_hsa006001.46933349
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.44434931
26Hippo signaling pathway_Homo sapiens_hsa043901.42481299
27Endometrial cancer_Homo sapiens_hsa052131.42150886
28Fatty acid biosynthesis_Homo sapiens_hsa000611.38553423
29Phenylalanine metabolism_Homo sapiens_hsa003601.36521968
30Mineral absorption_Homo sapiens_hsa049781.35972621
31Renal cell carcinoma_Homo sapiens_hsa052111.34574734
32Huntingtons disease_Homo sapiens_hsa050161.31868288
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30421350
34Toxoplasmosis_Homo sapiens_hsa051451.28254952
35Collecting duct acid secretion_Homo sapiens_hsa049661.26915124
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.19185862
37ABC transporters_Homo sapiens_hsa020101.17661243
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16969526
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15294100
40Sulfur metabolism_Homo sapiens_hsa009201.14726889
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.14484718
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11528657
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.10012248
44Phagosome_Homo sapiens_hsa041451.06957007
45Arachidonic acid metabolism_Homo sapiens_hsa005901.06316920
46Lysosome_Homo sapiens_hsa041421.05504254
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04138608
48TGF-beta signaling pathway_Homo sapiens_hsa043501.01918021
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99475605
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99205410
51Rheumatoid arthritis_Homo sapiens_hsa053230.98501234
52Thyroid cancer_Homo sapiens_hsa052160.97574669
53Chronic myeloid leukemia_Homo sapiens_hsa052200.97434182
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.92777936
55Dilated cardiomyopathy_Homo sapiens_hsa054140.90494607
56Retinol metabolism_Homo sapiens_hsa008300.89884961
57Malaria_Homo sapiens_hsa051440.88595667
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88384733
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88335959
60Pertussis_Homo sapiens_hsa051330.87451893
61beta-Alanine metabolism_Homo sapiens_hsa004100.87399007
62HIF-1 signaling pathway_Homo sapiens_hsa040660.84668627
63Pathways in cancer_Homo sapiens_hsa052000.81629285
64VEGF signaling pathway_Homo sapiens_hsa043700.80991204
65Rap1 signaling pathway_Homo sapiens_hsa040150.80936829
66Prostate cancer_Homo sapiens_hsa052150.79248842
67Non-small cell lung cancer_Homo sapiens_hsa052230.79192838
68Axon guidance_Homo sapiens_hsa043600.77902269
69Gastric acid secretion_Homo sapiens_hsa049710.77582539
70Salmonella infection_Homo sapiens_hsa051320.74055837
71Circadian rhythm_Homo sapiens_hsa047100.72494926
72Tyrosine metabolism_Homo sapiens_hsa003500.70679058
73Platelet activation_Homo sapiens_hsa046110.69471389
74MicroRNAs in cancer_Homo sapiens_hsa052060.68325008
75Thyroid hormone synthesis_Homo sapiens_hsa049180.67678838
76Choline metabolism in cancer_Homo sapiens_hsa052310.67587936
77Olfactory transduction_Homo sapiens_hsa047400.66541391
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66372909
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65746448
80Taste transduction_Homo sapiens_hsa047420.65090609
81PPAR signaling pathway_Homo sapiens_hsa033200.64409698
82Fatty acid degradation_Homo sapiens_hsa000710.63224323
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62298086
84Viral myocarditis_Homo sapiens_hsa054160.62276338
85Endocytosis_Homo sapiens_hsa041440.62051591
86Colorectal cancer_Homo sapiens_hsa052100.61404685
87Shigellosis_Homo sapiens_hsa051310.61023362
88Starch and sucrose metabolism_Homo sapiens_hsa005000.59496669
89Hepatitis C_Homo sapiens_hsa051600.59078305
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57991179
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56914952
92Peroxisome_Homo sapiens_hsa041460.55586791
93Basal cell carcinoma_Homo sapiens_hsa052170.55041089
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53458437
95TNF signaling pathway_Homo sapiens_hsa046680.53331714
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52603421
97Acute myeloid leukemia_Homo sapiens_hsa052210.51479018
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51317869
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50481527
100Hedgehog signaling pathway_Homo sapiens_hsa043400.50313664
101Prolactin signaling pathway_Homo sapiens_hsa049170.50030746
102Bile secretion_Homo sapiens_hsa049760.48825609
103Arginine and proline metabolism_Homo sapiens_hsa003300.48377273
104Leishmaniasis_Homo sapiens_hsa051400.47546476
105Dorso-ventral axis formation_Homo sapiens_hsa043200.46747791
106* Salivary secretion_Homo sapiens_hsa049700.46370808
107Insulin resistance_Homo sapiens_hsa049310.44941562
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44869976
109Melanoma_Homo sapiens_hsa052180.44776467
110ErbB signaling pathway_Homo sapiens_hsa040120.44000684
111Tuberculosis_Homo sapiens_hsa051520.42961569
112Melanogenesis_Homo sapiens_hsa049160.42840940
113Pentose phosphate pathway_Homo sapiens_hsa000300.42190567
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41856838
115Estrogen signaling pathway_Homo sapiens_hsa049150.41259799
116Arginine biosynthesis_Homo sapiens_hsa002200.40714154
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39360020
118Protein digestion and absorption_Homo sapiens_hsa049740.39338064
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.39331584
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.39173501
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38670464
122Notch signaling pathway_Homo sapiens_hsa043300.38666581
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.37888384
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36509720
125Glioma_Homo sapiens_hsa052140.35627733
126Glycerolipid metabolism_Homo sapiens_hsa005610.35146660
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34739572
128Renin-angiotensin system_Homo sapiens_hsa046140.34667156
129Allograft rejection_Homo sapiens_hsa053300.34478095
130Autoimmune thyroid disease_Homo sapiens_hsa053200.34279446
131Apoptosis_Homo sapiens_hsa042100.33715622
132Influenza A_Homo sapiens_hsa051640.33259713
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32671894
134Type I diabetes mellitus_Homo sapiens_hsa049400.31527118
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31369142
136Inositol phosphate metabolism_Homo sapiens_hsa005620.28087235
137Fructose and mannose metabolism_Homo sapiens_hsa000510.27733124
138Antigen processing and presentation_Homo sapiens_hsa046120.27622839
139Graft-versus-host disease_Homo sapiens_hsa053320.23903734
140Vitamin digestion and absorption_Homo sapiens_hsa049770.21379645
141Pancreatic secretion_Homo sapiens_hsa049720.20831834
142cAMP signaling pathway_Homo sapiens_hsa040240.19969110
143Fatty acid metabolism_Homo sapiens_hsa012120.19830804
144Calcium signaling pathway_Homo sapiens_hsa040200.17584957
145Metabolic pathways_Homo sapiens_hsa011000.17320068
146Synaptic vesicle cycle_Homo sapiens_hsa047210.16861069
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.16107171
148Insulin signaling pathway_Homo sapiens_hsa049100.15720034
149Complement and coagulation cascades_Homo sapiens_hsa046100.14212189

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