APOD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.82432083
2ensheathment of neurons (GO:0007272)6.55664366
3axon ensheathment (GO:0008366)6.55664366
4myelination (GO:0042552)6.54559895
5long-chain fatty acid biosynthetic process (GO:0042759)6.38882333
6response to methylmercury (GO:0051597)6.17412372
7myelin maintenance (GO:0043217)5.85413048
8cholesterol biosynthetic process (GO:0006695)5.57995435
9amyloid precursor protein metabolic process (GO:0042982)5.53456775
10negative regulation of protein localization to cell surface (GO:2000009)5.16698663
11establishment of mitochondrion localization (GO:0051654)5.11624926
12sterol biosynthetic process (GO:0016126)5.01274260
13negative regulation of neurotransmitter transport (GO:0051589)4.79735705
14regulation of collateral sprouting (GO:0048670)4.74562421
15long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.64601521
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.63462159
17positive regulation of oligodendrocyte differentiation (GO:0048714)4.62153360
18long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.51389036
19creatine metabolic process (GO:0006600)4.32304282
20isoprenoid biosynthetic process (GO:0008299)4.31045486
21cellular potassium ion homeostasis (GO:0030007)4.19831112
22response to lipoprotein particle (GO:0055094)4.16656655
23L-amino acid import (GO:0043092)4.10793850
24negative regulation of neurotransmitter secretion (GO:0046929)4.06621090
25fatty-acyl-CoA biosynthetic process (GO:0046949)4.04812460
26fatty-acyl-CoA metabolic process (GO:0035337)4.02228029
27photoreceptor cell differentiation (GO:0046530)4.00106235
28eye photoreceptor cell differentiation (GO:0001754)4.00106235
29glutamate secretion (GO:0014047)3.94941517
30glycerophospholipid catabolic process (GO:0046475)3.88314112
31sodium ion export (GO:0071436)3.88022945
32import into cell (GO:0098657)3.81643598
33very long-chain fatty acid metabolic process (GO:0000038)3.76618247
34neurotransmitter uptake (GO:0001504)3.72166872
35neuronal ion channel clustering (GO:0045161)3.65511321
36amyloid precursor protein catabolic process (GO:0042987)3.61987782
37response to redox state (GO:0051775)3.61759246
38oligodendrocyte differentiation (GO:0048709)3.61292653
39synaptic vesicle maturation (GO:0016188)3.51588178
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50687157
41astrocyte development (GO:0014002)3.49918052
42apical protein localization (GO:0045176)3.47327961
43neuron remodeling (GO:0016322)3.45869028
44membrane tubulation (GO:0097320)3.41871658
45magnesium ion transport (GO:0015693)3.40508474
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37886553
47synaptic vesicle exocytosis (GO:0016079)3.37098992
48protein neddylation (GO:0045116)3.35159148
49substantia nigra development (GO:0021762)3.32532162
50protein palmitoylation (GO:0018345)3.32515764
51asymmetric protein localization (GO:0008105)3.29547749
52extracellular matrix assembly (GO:0085029)3.28524187
53regulation of voltage-gated calcium channel activity (GO:1901385)3.24390816
54presynaptic membrane organization (GO:0097090)3.21522924
55GPI anchor biosynthetic process (GO:0006506)3.20107294
56thioester biosynthetic process (GO:0035384)3.16758049
57acyl-CoA biosynthetic process (GO:0071616)3.16758049
58heme transport (GO:0015886)3.12753008
59cell-cell junction maintenance (GO:0045217)3.12576851
60detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.12237302
61detection of temperature stimulus involved in sensory perception (GO:0050961)3.12237302
62GPI anchor metabolic process (GO:0006505)3.11581378
63positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.11481074
64myelination in peripheral nervous system (GO:0022011)3.11456105
65peripheral nervous system axon ensheathment (GO:0032292)3.11456105
66iron coordination entity transport (GO:1901678)3.08158761
67astrocyte differentiation (GO:0048708)3.06627426
68negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.05886671
69amino acid import (GO:0043090)3.04527821
70cell volume homeostasis (GO:0006884)3.04470781
71peptidyl-tyrosine autophosphorylation (GO:0038083)3.01899500
72cAMP biosynthetic process (GO:0006171)2.97218443
73potassium ion homeostasis (GO:0055075)2.96999228
74positive regulation of glial cell differentiation (GO:0045687)2.96244044
75activation of protein kinase A activity (GO:0034199)2.95186351
76regulation of synaptic vesicle exocytosis (GO:2000300)2.94438214
77peripheral nervous system development (GO:0007422)2.92247554
78limb bud formation (GO:0060174)2.89257746
79positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.89073267
80positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.86976261
81adult walking behavior (GO:0007628)2.85404676
82basement membrane organization (GO:0071711)2.85357387
83cGMP-mediated signaling (GO:0019934)2.85310376
84positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.85189425
85purine nucleotide transport (GO:0015865)2.83599661
86regulation of cell communication by electrical coupling (GO:0010649)2.82221367
87cell communication by electrical coupling (GO:0010644)2.80098453
88postsynaptic membrane organization (GO:0001941)2.79083837
89cartilage condensation (GO:0001502)2.79018125
90cell aggregation (GO:0098743)2.79018125
91chondroitin sulfate catabolic process (GO:0030207)2.78911287
92negative regulation of execution phase of apoptosis (GO:1900118)2.77991664
93regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77626305
94barbed-end actin filament capping (GO:0051016)2.77243447
95potassium ion import (GO:0010107)2.77118751
96negative regulation of macroautophagy (GO:0016242)2.77033372
97glycosylceramide metabolic process (GO:0006677)2.74705293
98regulation of somitogenesis (GO:0014807)2.73565221
99positive regulation of astrocyte differentiation (GO:0048711)2.72720426
100positive regulation of gliogenesis (GO:0014015)2.68110570
101cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.66561118
102regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.66032630
103positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.65527252
104negative regulation of axonogenesis (GO:0050771)2.64518845
105detection of calcium ion (GO:0005513)2.64439686
106organ growth (GO:0035265)2.64057475
107peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.63880491
108response to dietary excess (GO:0002021)2.63330931
109positive regulation of synapse maturation (GO:0090129)2.63325484
110vitamin A metabolic process (GO:0006776)2.62958877
111cerebral cortex radially oriented cell migration (GO:0021799)2.62909096
112peptidyl-cysteine modification (GO:0018198)2.62573736
113cell junction maintenance (GO:0034331)2.62405830
114preassembly of GPI anchor in ER membrane (GO:0016254)2.62022545
115melanocyte differentiation (GO:0030318)2.61441153
116negative regulation of Rho protein signal transduction (GO:0035024)2.59909736
117pigment cell differentiation (GO:0050931)2.58638320
118enteric nervous system development (GO:0048484)2.58521387
119phosphatidylserine acyl-chain remodeling (GO:0036150)2.57472314
120regulation of synaptic vesicle transport (GO:1902803)2.57076438
121regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.56433794
122positive regulation of actin filament depolymerization (GO:0030836)2.55363347
123nucleotide transmembrane transport (GO:1901679)2.55306743
124positive regulation of pseudopodium assembly (GO:0031274)2.55042424
125negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.55015803
126locomotory exploration behavior (GO:0035641)2.54844941
127vocalization behavior (GO:0071625)2.54749188
128regulation of neuronal synaptic plasticity (GO:0048168)2.54209578
129long-term synaptic potentiation (GO:0060291)2.54193124
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.53241704
131nerve growth factor signaling pathway (GO:0038180)2.52979588
132alcohol biosynthetic process (GO:0046165)2.52621988
133hyperosmotic salinity response (GO:0042538)2.51955659
134neurotransmitter secretion (GO:0007269)2.50654397
135regulation of synapse maturation (GO:0090128)2.47544991
136cerebellar granule cell differentiation (GO:0021707)2.47267820
137negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.47163106
138detection of temperature stimulus (GO:0016048)2.47115546
139regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.46101832
140cellular sodium ion homeostasis (GO:0006883)2.46053923
141regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.44894383
142cellular response to electrical stimulus (GO:0071257)2.43947226
143cholesterol metabolic process (GO:0008203)2.43851853
144neuronal action potential propagation (GO:0019227)2.43748967
145presynaptic membrane assembly (GO:0097105)2.43706059
146cell communication involved in cardiac conduction (GO:0086065)2.42884256
147negative regulation of JUN kinase activity (GO:0043508)2.42361716
148mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.42283195
149neuromuscular process controlling balance (GO:0050885)2.41832308
150L-glutamate transport (GO:0015813)2.40625045
151leukocyte migration involved in inflammatory response (GO:0002523)2.40246951
152positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.40170181
153cranial nerve development (GO:0021545)2.39749475
154substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.39650058
155substrate-independent telencephalic tangential migration (GO:0021826)2.39650058
156regulation of actin filament-based movement (GO:1903115)2.39242267
157positive regulation of cellular amine metabolic process (GO:0033240)2.38419938
158dermatan sulfate metabolic process (GO:0030205)2.38214325
159regulation of calcium ion transmembrane transporter activity (GO:1901019)2.37310294
160regulation of calcium ion transmembrane transport (GO:1903169)2.37310294
161cellular response to epinephrine stimulus (GO:0071872)2.37214828
162dermatan sulfate biosynthetic process (GO:0030208)2.36581687
163righting reflex (GO:0060013)2.34052386
164regulation of skeletal muscle cell differentiation (GO:2001014)2.33522029
165negative regulation of catenin import into nucleus (GO:0035414)2.30767574
166regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.30727941
167semaphorin-plexin signaling pathway (GO:0071526)2.29714463
168negative regulation of homotypic cell-cell adhesion (GO:0034111)2.29392917
169regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.28980103
170cardiac muscle contraction (GO:0060048)2.28783661
171cellular response to monoamine stimulus (GO:0071868)2.26535474
172cellular response to catecholamine stimulus (GO:0071870)2.26535474
173regulation of cardiac muscle cell contraction (GO:0086004)2.26103506
174regulation of gonadotropin secretion (GO:0032276)2.25660552
175regulation of synaptic plasticity (GO:0048167)2.24749053
176glycosphingolipid biosynthetic process (GO:0006688)2.21945446
177striated muscle hypertrophy (GO:0014897)2.21846229
178growth hormone receptor signaling pathway (GO:0060396)2.21084552
179regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.20740800
180axon ensheathment in central nervous system (GO:0032291)13.1132689
181central nervous system myelination (GO:0022010)13.1132689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.02325720
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.01486890
3GBX2_23144817_ChIP-Seq_PC3_Human2.83782879
4EZH2_22144423_ChIP-Seq_EOC_Human2.75140923
5SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.66464993
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38007523
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32601312
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23755034
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.22532906
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.15738029
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11499072
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.10467996
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.09724651
14* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.07090002
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04339603
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99929613
17MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97101387
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96719731
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96719731
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.93225280
21AR_21572438_ChIP-Seq_LNCaP_Human1.93092497
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90340103
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.89701318
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88955704
25TAF15_26573619_Chip-Seq_HEK293_Human1.88307148
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85837366
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84689755
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84077140
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82322247
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.81320671
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80644478
32VDR_22108803_ChIP-Seq_LS180_Human1.74266784
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73888076
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72701234
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72695733
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.71428349
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70276763
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.59259656
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57912987
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56629846
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.56520408
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54876684
43KDM2B_26808549_Chip-Seq_K562_Human1.54825885
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54719570
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51274670
46LXR_22292898_ChIP-Seq_THP-1_Human1.51234042
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.50910941
48TBX20_22080862_ChIP-Seq_HEART_Mouse1.50910941
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47172997
50STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.46877311
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.46166160
52* ER_23166858_ChIP-Seq_MCF-7_Human1.44293421
53* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42628865
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41307976
55CLOCK_20551151_ChIP-Seq_293T_Human1.41220445
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40974772
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39858370
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38799673
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38522500
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36837311
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36602104
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36602104
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31833920
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.31319687
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29692448
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29237550
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28876320
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.28628695
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.27760066
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26614835
71DROSHA_22980978_ChIP-Seq_HELA_Human1.21886464
72P300_19829295_ChIP-Seq_ESCs_Human1.21553789
73LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20922239
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20724707
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20032510
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19820813
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18357952
78EOMES_21245162_ChIP-Seq_HESCs_Human1.18214937
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16397292
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16275131
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16003334
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15123282
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15067805
84REST_21632747_ChIP-Seq_MESCs_Mouse1.14648758
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14479239
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13223319
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.13103079
88CTCF_27219007_Chip-Seq_Bcells_Human1.12664469
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.12602991
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11787531
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11148430
92SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11085870
93FUS_26573619_Chip-Seq_HEK293_Human1.10529572
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09474649
95CMYC_18555785_Chip-Seq_ESCs_Mouse1.08687333
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08524866
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07073833
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.06933112
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.06284143
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.05549918
101HTT_18923047_ChIP-ChIP_STHdh_Human1.05101834
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05074125
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04947409
104RACK7_27058665_Chip-Seq_MCF-7_Human1.04753296
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04393598
106NANOG_19829295_ChIP-Seq_ESCs_Human1.03590236
107SOX2_19829295_ChIP-Seq_ESCs_Human1.03590236
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03060035
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.02681466
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.02226573
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01080229
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00859868
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00810115
114TP53_16413492_ChIP-PET_HCT116_Human0.99827030
115SMAD_19615063_ChIP-ChIP_OVARY_Human0.99555853
116CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99446374
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98989781
118* STAT3_23295773_ChIP-Seq_U87_Human0.98985969
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.98405879
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98373487
121ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98337649
122ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98316979
123SMAD4_21741376_ChIP-Seq_EPCs_Human0.98263350
124* TP53_23651856_ChIP-Seq_MEFs_Mouse0.97803041
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97613565
126LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97165106
127REST_18959480_ChIP-ChIP_MESCs_Mouse0.96860129
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96504549
129P300_18555785_Chip-Seq_ESCs_Mouse0.96450516
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96137780
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96136997
132POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95647082
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94781526
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94592073
135SMC4_20622854_ChIP-Seq_HELA_Human0.93731824
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92844056
137* MITF_21258399_ChIP-Seq_MELANOMA_Human0.92727162
138SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92458687
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92324815
140TP53_20018659_ChIP-ChIP_R1E_Mouse0.91764772
141TRIM28_21343339_ChIP-Seq_HEK293_Human0.90886865
142ESR2_21235772_ChIP-Seq_MCF-7_Human0.90745909
143GATA1_26923725_Chip-Seq_HPCs_Mouse0.89858933
144AHR_22903824_ChIP-Seq_MCF-7_Human0.89629679
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89450382
146* RARB_27405468_Chip-Seq_BRAIN_Mouse0.88540307
147SMAD4_21799915_ChIP-Seq_A2780_Human0.88227728
148KDM2B_26808549_Chip-Seq_REH_Human0.88140554
149RING1B_27294783_Chip-Seq_NPCs_Mouse0.88036724
150OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87960464
151TCF4_23295773_ChIP-Seq_U87_Human0.87689541
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87601442
153STAT3_18555785_Chip-Seq_ESCs_Mouse0.87500158
154EGR1_19032775_ChIP-ChIP_M12_Human0.87346592
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87317192
156MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87083545
157ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86065014
158CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84532436
159SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83189595
160P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79131058
161RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78249545
162TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.78095795
163AR_19668381_ChIP-Seq_PC3_Human0.77132201
164DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76918305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.60604548
2MP0003950_abnormal_plasma_membrane4.10928190
3MP0003011_delayed_dark_adaptation3.88082504
4MP0003880_abnormal_central_pattern3.12804802
5MP0003690_abnormal_glial_cell3.09974234
6MP0004270_analgesia2.90612719
7MP0003329_amyloid_beta_deposits2.85337513
8MP0001529_abnormal_vocalization2.80650696
9MP0005171_absent_coat_pigmentation2.78050224
10MP0005503_abnormal_tendon_morphology2.76265633
11MP0005670_abnormal_white_adipose2.74467581
12MP0000751_myopathy2.64213667
13MP0005423_abnormal_somatic_nervous2.47079619
14MP0003136_yellow_coat_color2.45847422
15MP0004885_abnormal_endolymph2.45629867
16MP0002272_abnormal_nervous_system2.39563648
17MP0004742_abnormal_vestibular_system2.38850815
18MP0001905_abnormal_dopamine_level2.38189971
19MP0005275_abnormal_skin_tensile2.36829498
20MP0001486_abnormal_startle_reflex2.35150956
21MP0003634_abnormal_glial_cell2.24444871
22MP0004142_abnormal_muscle_tone2.20782085
23MP0003806_abnormal_nucleotide_metabolis2.18375729
24MP0005409_darkened_coat_color2.17479695
25MP0003195_calcinosis2.16043727
26MP0009780_abnormal_chondrocyte_physiolo2.11341363
27MP0004043_abnormal_pH_regulation2.04000207
28MP0005075_abnormal_melanosome_morpholog2.02817838
29MP0005410_abnormal_fertilization1.99517096
30MP0002064_seizures1.91498221
31MP0001485_abnormal_pinna_reflex1.88520283
32MP0000778_abnormal_nervous_system1.84867920
33MP0010678_abnormal_skin_adnexa1.84626172
34MP0004272_abnormal_basement_membrane1.82285050
35MP0003632_abnormal_nervous_system1.79924826
36MP0004858_abnormal_nervous_system1.79830498
37MP0002229_neurodegeneration1.72494468
38MP0008260_abnormal_autophagy1.64842117
39MP0001502_abnormal_circadian_rhythm1.63221001
40MP0000604_amyloidosis1.62626401
41MP0004130_abnormal_muscle_cell1.60530365
42MP0003279_aneurysm1.56728193
43MP0000462_abnormal_digestive_system1.56716787
44MP0004134_abnormal_chest_morphology1.52941434
45MP0004381_abnormal_hair_follicle1.49556679
46MP0002734_abnormal_mechanical_nocicepti1.48739471
47* MP0003631_nervous_system_phenotype1.46999839
48MP0000383_abnormal_hair_follicle1.45056488
49MP0002108_abnormal_muscle_morphology1.44803261
50MP0003635_abnormal_synaptic_transmissio1.43880027
51MP0005257_abnormal_intraocular_pressure1.38908257
52MP0005551_abnormal_eye_electrophysiolog1.38206799
53MP0003879_abnormal_hair_cell1.37746861
54MP0001970_abnormal_pain_threshold1.35879177
55* MP0003633_abnormal_nervous_system1.33236301
56MP0009745_abnormal_behavioral_response1.32409904
57MP0005058_abnormal_lysosome_morphology1.31368544
58MP0006138_congestive_heart_failure1.31044062
59MP0005451_abnormal_body_composition1.30275384
60MP0004859_abnormal_synaptic_plasticity1.29195222
61MP0005666_abnormal_adipose_tissue1.28232380
62MP0009046_muscle_twitch1.26112318
63MP0004084_abnormal_cardiac_muscle1.25897733
64MP0008569_lethality_at_weaning1.25642821
65MP0003705_abnormal_hypodermis_morpholog1.25283563
66MP0000955_abnormal_spinal_cord1.24249271
67MP0001958_emphysema1.21770566
68MP0008438_abnormal_cutaneous_collagen1.20065775
69MP0002572_abnormal_emotion/affect_behav1.19748751
70MP0000747_muscle_weakness1.17869960
71MP0002295_abnormal_pulmonary_circulatio1.17818619
72MP0005623_abnormal_meninges_morphology1.17633637
73MP0005167_abnormal_blood-brain_barrier1.16781497
74MP0003656_abnormal_erythrocyte_physiolo1.16463968
75MP0002882_abnormal_neuron_morphology1.14739563
76MP0001440_abnormal_grooming_behavior1.14300404
77MP0000762_abnormal_tongue_morphology1.14111322
78MP0001963_abnormal_hearing_physiology1.12074080
79MP0000647_abnormal_sebaceous_gland1.10934949
80MP0003045_fibrosis1.08414046
81* MP0002066_abnormal_motor_capabilities/c1.08292791
82MP0005248_abnormal_Harderian_gland1.07519592
83MP0003878_abnormal_ear_physiology1.07411251
84MP0005377_hearing/vestibular/ear_phenot1.07411251
85MP0005195_abnormal_posterior_eye1.06407443
86MP0005375_adipose_tissue_phenotype1.05352506
87MP0001968_abnormal_touch/_nociception1.05009773
88MP0002938_white_spotting1.04869041
89MP0002067_abnormal_sensory_capabilities1.04427592
90MP0004215_abnormal_myocardial_fiber1.01530949
91MP0001851_eye_inflammation1.00557118
92MP0004036_abnormal_muscle_relaxation1.00532251
93MP0009840_abnormal_foam_cell0.99966800
94MP0002752_abnormal_somatic_nervous0.99487030
95* MP0002063_abnormal_learning/memory/cond0.99443608
96MP0000579_abnormal_nail_morphology0.98847991
97MP0005620_abnormal_muscle_contractility0.98522181
98MP0004087_abnormal_muscle_fiber0.97140239
99MP0002972_abnormal_cardiac_muscle0.96941289
100MP0005508_abnormal_skeleton_morphology0.96232587
101MP0000759_abnormal_skeletal_muscle0.96172027
102MP0002909_abnormal_adrenal_gland0.95190039
103MP0004145_abnormal_muscle_electrophysio0.94191695
104MP0002733_abnormal_thermal_nociception0.93793615
105MP0000003_abnormal_adipose_tissue0.90250310
106MP0002736_abnormal_nociception_after0.89894397
107MP0001177_atelectasis0.89789817
108MP0005386_behavior/neurological_phenoty0.88760732
109MP0004924_abnormal_behavior0.88760732
110MP0001299_abnormal_eye_distance/0.88263368
111MP0005330_cardiomyopathy0.86036605
112MP0003091_abnormal_cell_migration0.85523277
113MP0003075_altered_response_to0.84874660
114MP0001346_abnormal_lacrimal_gland0.84185500
115MP0002971_abnormal_brown_adipose0.83789241
116MP0005595_abnormal_vascular_smooth0.82528885
117MP0004484_altered_response_of0.82363683
118MP0000749_muscle_degeneration0.81734806
119MP0006082_CNS_inflammation0.80065527
120MP0002060_abnormal_skin_morphology0.78588042
121MP0003938_abnormal_ear_development0.78460749
122MP0005253_abnormal_eye_physiology0.78359358
123MP0002735_abnormal_chemical_nociception0.78190352
124MP0000372_irregular_coat_pigmentation0.77049789
125MP0000015_abnormal_ear_pigmentation0.75815460
126MP0005369_muscle_phenotype0.75294862
127MP0009250_abnormal_appendicular_skeleto0.75201001
128MP0005388_respiratory_system_phenotype0.74677631
129MP0002133_abnormal_respiratory_system0.74677631
130MP0002822_catalepsy0.73644830
131MP0001348_abnormal_lacrimal_gland0.73341933
132MP0005165_increased_susceptibility_to0.73178096
133MP0004085_abnormal_heartbeat0.73076107
134MP0001340_abnormal_eyelid_morphology0.72873118
135MP0000569_abnormal_digit_pigmentation0.72335060
136MP0006072_abnormal_retinal_apoptosis0.71700705
137MP0002557_abnormal_social/conspecific_i0.68585316
138MP0003183_abnormal_peptide_metabolism0.68333007
139MP0002152_abnormal_brain_morphology0.68030729
140MP0004147_increased_porphyrin_level0.67250813
141MP0005535_abnormal_body_temperature0.67101541
142MP0005646_abnormal_pituitary_gland0.66718191
143MP0003937_abnormal_limbs/digits/tail_de0.66439446
144MP0000026_abnormal_inner_ear0.64403504
145MP0005408_hypopigmentation0.63605010
146MP0002933_joint_inflammation0.61518902
147MP0001501_abnormal_sleep_pattern0.60044884
148MP0001661_extended_life_span0.59716142
149MP0000566_synostosis0.59174382
150MP0002090_abnormal_vision0.59105211

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.94306978
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.61908217
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.61908217
4Cerebral inclusion bodies (HP:0100314)5.08441103
5Abnormality of the corticospinal tract (HP:0002492)4.86070406
6Peripheral hypomyelination (HP:0007182)4.50017249
7Parakeratosis (HP:0001036)4.44639507
8Onion bulb formation (HP:0003383)4.18493622
9Insidious onset (HP:0003587)4.18167423
10Termporal pattern (HP:0011008)4.18167423
11Supranuclear gaze palsy (HP:0000605)3.99115214
12Segmental peripheral demyelination/remyelination (HP:0003481)3.91229912
13Obstructive sleep apnea (HP:0002870)3.87466467
14Increased serum pyruvate (HP:0003542)3.82656599
15Abnormality of glycolysis (HP:0004366)3.82656599
16Distal lower limb muscle weakness (HP:0009053)3.69272254
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.56728039
18Cerebral hypomyelination (HP:0006808)3.47554343
19Blue irides (HP:0000635)3.44737336
20Retinal dysplasia (HP:0007973)3.33699255
21Abnormal auditory evoked potentials (HP:0006958)3.30791467
22Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.26423782
23Distal upper limb amyotrophy (HP:0007149)3.24693157
24Upper limb amyotrophy (HP:0009129)3.24693157
25Hand muscle atrophy (HP:0009130)3.21936647
26Cerebral aneurysm (HP:0004944)3.21556222
27Spastic gait (HP:0002064)3.20951735
28Leukodystrophy (HP:0002415)3.18042329
29Scanning speech (HP:0002168)3.14614810
30Sensory axonal neuropathy (HP:0003390)3.13630072
31Heterochromia iridis (HP:0001100)3.09322727
32Type 1 muscle fiber predominance (HP:0003803)3.09207307
33Ankle clonus (HP:0011448)3.00419342
34Axonal loss (HP:0003447)2.92838165
35Increased variability in muscle fiber diameter (HP:0003557)2.90273689
36Dysmetria (HP:0001310)2.89955124
37Shallow orbits (HP:0000586)2.87430874
38Slow saccadic eye movements (HP:0000514)2.85507770
39Hypoplastic pelvis (HP:0008839)2.81467590
40Intention tremor (HP:0002080)2.81405440
41Upper limb muscle weakness (HP:0003484)2.80743527
42Hypoplasia of the iris (HP:0007676)2.76786464
43Hypophosphatemic rickets (HP:0004912)2.74982169
44Protrusio acetabuli (HP:0003179)2.73484266
45Stridor (HP:0010307)2.68922318
46Congenital ichthyosiform erythroderma (HP:0007431)2.67225798
47Bundle branch block (HP:0011710)2.65616614
48Increased connective tissue (HP:0009025)2.60561215
49Cerebral hemorrhage (HP:0001342)2.59620556
50Alacrima (HP:0000522)2.58457210
51Myokymia (HP:0002411)2.56468746
52Abnormality of skeletal muscle fiber size (HP:0012084)2.54394087
53CNS hypomyelination (HP:0003429)2.53609484
54Autoamputation (HP:0001218)2.51263993
55Anteriorly placed anus (HP:0001545)2.49610923
56Foot dorsiflexor weakness (HP:0009027)2.47106723
57Torticollis (HP:0000473)2.46962075
58Absent septum pellucidum (HP:0001331)2.44641364
59Ocular albinism (HP:0001107)2.44188601
60Clumsiness (HP:0002312)2.42488165
61Abnormal pupillary function (HP:0007686)2.41582888
62Metabolic alkalosis (HP:0200114)2.41505430
63Spinal rigidity (HP:0003306)2.39547835
64Morphological abnormality of the inner ear (HP:0011390)2.37501239
65Spastic paraparesis (HP:0002313)2.34654540
66Methylmalonic acidemia (HP:0002912)2.33607640
67Pheochromocytoma (HP:0002666)2.33280004
68J-shaped sella turcica (HP:0002680)2.31254133
69Diplopia (HP:0000651)2.30119022
70Abnormality of binocular vision (HP:0011514)2.30119022
71Abnormality of the phalanges of the 2nd finger (HP:0009541)2.29788503
72Muscle fiber splitting (HP:0003555)2.29520513
73Increased circulating renin level (HP:0000848)2.29242239
74Abnormality of the foot musculature (HP:0001436)2.26836034
75Hypoventilation (HP:0002791)2.26563571
76Steppage gait (HP:0003376)2.23702840
77Spastic tetraparesis (HP:0001285)2.23546278
78Mildly elevated creatine phosphokinase (HP:0008180)2.22368873
79Postural tremor (HP:0002174)2.21756237
80Hepatosplenomegaly (HP:0001433)2.21557478
81Focal motor seizures (HP:0011153)2.17575284
82Iris hypopigmentation (HP:0007730)2.17327793
83Abnormality of the calf musculature (HP:0001430)2.16871384
84Action tremor (HP:0002345)2.16113322
85Decreased motor nerve conduction velocity (HP:0003431)2.15568612
86Nonprogressive disorder (HP:0003680)2.14625240
87Hypopigmentation of the fundus (HP:0007894)2.14244179
88Patchy hypopigmentation of hair (HP:0011365)2.13593983
89Hammertoe (HP:0001765)2.13237105
90Asymmetric septal hypertrophy (HP:0001670)2.13156565
91Thickened helices (HP:0000391)2.11044772
92Lower limb muscle weakness (HP:0007340)2.10908314
93Bulbar palsy (HP:0001283)2.10786528
94Coronal craniosynostosis (HP:0004440)2.10781774
95Hyporeflexia of lower limbs (HP:0002600)2.09943732
96Infantile muscular hypotonia (HP:0008947)2.09575577
97Hypokalemic alkalosis (HP:0001949)2.08814768
98Abnormality of the septum pellucidum (HP:0007375)2.07456156
99Abnormality of the salivary glands (HP:0010286)2.06982851
100Buphthalmos (HP:0000557)2.06914231
101Turricephaly (HP:0000262)2.06334432
102EMG: myopathic abnormalities (HP:0003458)2.06161661
103White forelock (HP:0002211)2.05634978
104Increased CSF protein (HP:0002922)2.05287449
105Aplasia involving bones of the extremities (HP:0009825)2.02768760
106Aplasia involving bones of the upper limbs (HP:0009823)2.02768760
107Aplasia of the phalanges of the hand (HP:0009802)2.02768760
108Diaphragmatic weakness (HP:0009113)2.02132995
109Fetal akinesia sequence (HP:0001989)2.02034764
110Abnormality of the middle phalanges of the toes (HP:0010183)2.00921617
111Peripheral demyelination (HP:0011096)2.00757324
112Abnormal atrioventricular conduction (HP:0005150)2.00571756
113Neuroendocrine neoplasm (HP:0100634)1.99748579
114Acute necrotizing encephalopathy (HP:0006965)1.99124332
115Abnormality of the musculature of the hand (HP:0001421)1.98711707
116Split foot (HP:0001839)1.98402376
117Distal lower limb amyotrophy (HP:0008944)1.96416587
118Sudden death (HP:0001699)1.96171360
119Hypomagnesemia (HP:0002917)1.96061210
120Decreased lacrimation (HP:0000633)1.95576541
121Lower limb amyotrophy (HP:0007210)1.95369717
122Gowers sign (HP:0003391)1.95171730
123Exercise-induced myalgia (HP:0003738)1.94336375
124Vertebral compression fractures (HP:0002953)1.94076537
125Premature skin wrinkling (HP:0100678)1.92535026
126Difficulty running (HP:0009046)1.91848800
127Sleep apnea (HP:0010535)1.91291723
128Megalencephaly (HP:0001355)1.90610805
129Epiphyseal dysplasia (HP:0002656)1.88714047
130Focal seizures (HP:0007359)1.87613832
131Centrally nucleated skeletal muscle fibers (HP:0003687)1.87291612
132Esophageal atresia (HP:0002032)1.86646282
133Achilles tendon contracture (HP:0001771)1.86554440
134Glomerulonephritis (HP:0000099)1.86431991
135Type II lissencephaly (HP:0007260)1.84822058
136Myelomeningocele (HP:0002475)1.84627723
137Craniofacial dystonia (HP:0012179)1.84127236
138Acute encephalopathy (HP:0006846)1.84064178
139Urinary urgency (HP:0000012)1.83555386
140Scapular winging (HP:0003691)1.82733565
141Heart block (HP:0012722)1.82720324
142Hemiparesis (HP:0001269)1.81215297
143Paraparesis (HP:0002385)1.80832407
144Prolonged neonatal jaundice (HP:0006579)1.80183443
145Distal sensory impairment (HP:0002936)1.80052070
146Confusion (HP:0001289)1.78941506
147Neuronal loss in central nervous system (HP:0002529)1.78649924
148Choreoathetosis (HP:0001266)1.78515008
149Spinal cord compression (HP:0002176)1.78261816
150Clonus (HP:0002169)1.78068354
151Morphological abnormality of the pyramidal tract (HP:0002062)1.77405075
152Aplasia of the musculature (HP:0100854)1.77058909
153Ulnar claw (HP:0001178)1.76871941
154Focal dystonia (HP:0004373)1.76792973
155Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.76689415
156Muscle hypertrophy of the lower extremities (HP:0008968)1.76348912
157Generalized amyotrophy (HP:0003700)1.75247387
158Poor speech (HP:0002465)1.72585209
159Bowel incontinence (HP:0002607)1.72374377
160Urinary incontinence (HP:0000020)1.71749051
161Truncal ataxia (HP:0002078)1.70141586
162Neck muscle weakness (HP:0000467)1.69714223
163Complement deficiency (HP:0004431)1.68700557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.04966127
2EPHB14.26478216
3MAPKAPK54.08462503
4OXSR13.70375610
5PBK3.20278047
6RIPK13.07332109
7PKN12.93620731
8LMTK22.73327490
9PNCK2.69011077
10WNK42.52661396
11TESK22.41107150
12NTRK32.39681198
13BCR2.12425359
14UHMK12.09998448
15MET2.04985069
16DAPK22.04948985
17FGFR22.03293333
18LATS22.00294470
19LIMK11.94579789
20TRIB31.88532997
21WNK11.81626809
22MST41.70326410
23CAMK2B1.60280266
24MYLK1.59525123
25CSNK1G31.57278895
26NTRK11.56873971
27PDGFRA1.56112601
28CSNK1A1L1.54852925
29SGK2231.50473479
30SGK4941.50473479
31TTN1.47661649
32CLK11.42718874
33ROCK21.38279207
34CAMKK11.36807860
35MOS1.35965379
36CAMK2D1.29808230
37DYRK21.29353657
38CAMK1G1.23521285
39CDK191.23432415
40FGR1.21911402
41TESK11.19826221
42CSNK1G11.19019615
43MARK21.15130186
44MAP3K31.14951469
45CSNK1G21.13692587
46ERBB41.13532949
47CASK1.13120750
48MAP3K61.07938491
49RIPK41.05396645
50MAPKAPK31.04824243
51PRKD11.01854290
52MAPK151.00923830
53NEK60.98881078
54CAMK2G0.97400777
55MARK10.97292932
56FER0.97227838
57MUSK0.96720833
58RET0.96061879
59PTK20.95907549
60PDGFRB0.95364689
61MKNK10.94550825
62PINK10.94549208
63ERN10.93739922
64TNK20.90835691
65SIK10.90591791
66MAP2K20.90315764
67CAMK2A0.89892666
68NME20.89306728
69TIE10.88731705
70RPS6KA50.85530767
71MAP3K130.85266238
72SGK20.84862055
73TGFBR20.84386650
74PAK60.84125312
75PAK30.82722587
76PHKG20.81323058
77PHKG10.81323058
78EPHA30.80480832
79PRKCE0.77503904
80ICK0.77236643
81SGK30.75061754
82STK380.74237268
83ROCK10.73486685
84CDK140.73354871
85MINK10.71653508
86BMPR1B0.71457537
87PRKCQ0.70378083
88CDK50.69059147
89PAK40.66840364
90GSK3A0.65869367
91CDK150.65089552
92AKT30.64051582
93MAPK100.64017026
94MAP3K110.63446355
95SGK10.63036576
96MAP3K10.61810540
97CDC42BPA0.60517120
98TYRO30.59541157
99CDK180.59167632
100MAP2K10.57918073
101TNIK0.57493402
102CDK11A0.57250068
103PDK10.56325646
104PRKG10.56158444
105CSNK1D0.55612274
106GRK70.55224906
107DAPK10.53646182
108PDPK10.53133985
109KSR20.53040076
110ABL20.52120564
111EPHA40.51205895
112CAMK40.51140360
113PRKACB0.50183507
114CSNK1A10.47342433
115FYN0.46877230
116OBSCN0.46120189
117DDR20.45814512
118DAPK30.45534829
119MAPK130.44951686
120GRK50.44389650
121HIPK20.42214764
122ADRBK20.42127722
123BUB10.40956268
124NTRK20.39372595
125MAPK120.38213218
126PRKD30.38179883
127DMPK0.37917727
128MAP3K20.37142768
129PIK3CA0.37133764
130PRKACA0.35117926
131PAK10.34638965
132PAK20.34185974
133DYRK1A0.33561398
134PLK20.32062243
135ARAF0.31016090
136CSNK1E0.29643112
137PRPF4B0.29542549
138IRAK20.29399264
139GRK10.29362795
140MAPK40.29312526
141PRKD20.28831689
142PRKCH0.27922297
143INSR0.27732571
144CAMK10.26294363
145BMPR20.24840165
146STK110.24733325
147PTK2B0.24469840
148MAPK70.23754939

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.73934119
2Fatty acid elongation_Homo sapiens_hsa000624.87950099
3Steroid biosynthesis_Homo sapiens_hsa001004.85288716
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.37318385
5Ether lipid metabolism_Homo sapiens_hsa005653.19745832
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.05878408
7Nitrogen metabolism_Homo sapiens_hsa009102.80510551
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.67391664
9Vitamin B6 metabolism_Homo sapiens_hsa007502.24412017
10Histidine metabolism_Homo sapiens_hsa003402.20943281
11Phenylalanine metabolism_Homo sapiens_hsa003602.12873610
12Synaptic vesicle cycle_Homo sapiens_hsa047212.04947856
13Dilated cardiomyopathy_Homo sapiens_hsa054141.99616943
14Protein export_Homo sapiens_hsa030601.90948574
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88170618
16Sulfur metabolism_Homo sapiens_hsa009201.85325212
17Oxidative phosphorylation_Homo sapiens_hsa001901.84307864
18Linoleic acid metabolism_Homo sapiens_hsa005911.80634833
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77887670
20Insulin secretion_Homo sapiens_hsa049111.73752387
21Long-term potentiation_Homo sapiens_hsa047201.68775018
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63468830
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.52802545
24Amphetamine addiction_Homo sapiens_hsa050311.52386545
25Circadian rhythm_Homo sapiens_hsa047101.48741656
26Butanoate metabolism_Homo sapiens_hsa006501.47693921
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47074524
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46670402
29Sphingolipid metabolism_Homo sapiens_hsa006001.46580721
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46319345
31Parkinsons disease_Homo sapiens_hsa050121.44179855
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43474162
33PPAR signaling pathway_Homo sapiens_hsa033201.36143704
34Alzheimers disease_Homo sapiens_hsa050101.31541136
35GABAergic synapse_Homo sapiens_hsa047271.27635456
36Focal adhesion_Homo sapiens_hsa045101.24753641
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17553834
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17282286
39Calcium signaling pathway_Homo sapiens_hsa040201.13641157
40Protein digestion and absorption_Homo sapiens_hsa049741.13162547
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11680182
42Glutamatergic synapse_Homo sapiens_hsa047241.11625585
43Oxytocin signaling pathway_Homo sapiens_hsa049211.10192207
44Serotonergic synapse_Homo sapiens_hsa047261.08847061
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08321746
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08238255
47cAMP signaling pathway_Homo sapiens_hsa040241.08238105
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07209697
49GnRH signaling pathway_Homo sapiens_hsa049121.05791829
50Arginine and proline metabolism_Homo sapiens_hsa003301.05533526
51Estrogen signaling pathway_Homo sapiens_hsa049151.05392139
52Axon guidance_Homo sapiens_hsa043601.03117132
53Bile secretion_Homo sapiens_hsa049761.02937478
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.01700931
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.99119387
56Renal cell carcinoma_Homo sapiens_hsa052110.92073319
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90769878
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85955836
59Long-term depression_Homo sapiens_hsa047300.84870479
60Fatty acid metabolism_Homo sapiens_hsa012120.84826976
61Propanoate metabolism_Homo sapiens_hsa006400.83362451
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82857778
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.82121381
64Mineral absorption_Homo sapiens_hsa049780.81616522
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81322695
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80417137
67Morphine addiction_Homo sapiens_hsa050320.79697990
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.79643047
69Glioma_Homo sapiens_hsa052140.79113313
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78811286
71Arachidonic acid metabolism_Homo sapiens_hsa005900.77042049
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75316417
73Cardiac muscle contraction_Homo sapiens_hsa042600.74957240
74Glutathione metabolism_Homo sapiens_hsa004800.74612223
75Tight junction_Homo sapiens_hsa045300.74064990
76Cocaine addiction_Homo sapiens_hsa050300.71714024
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71673884
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.69579318
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69544485
80Chemical carcinogenesis_Homo sapiens_hsa052040.68269596
81Ovarian steroidogenesis_Homo sapiens_hsa049130.67919647
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.67910944
83Rap1 signaling pathway_Homo sapiens_hsa040150.67322096
84AMPK signaling pathway_Homo sapiens_hsa041520.66522744
85Vibrio cholerae infection_Homo sapiens_hsa051100.66438432
86Glucagon signaling pathway_Homo sapiens_hsa049220.65874341
87Thyroid hormone synthesis_Homo sapiens_hsa049180.65591268
88Circadian entrainment_Homo sapiens_hsa047130.65328292
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64622411
90Huntingtons disease_Homo sapiens_hsa050160.63435004
91Collecting duct acid secretion_Homo sapiens_hsa049660.63424310
92Insulin signaling pathway_Homo sapiens_hsa049100.62862969
93Amoebiasis_Homo sapiens_hsa051460.61027273
94VEGF signaling pathway_Homo sapiens_hsa043700.60774935
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60370909
96Gastric acid secretion_Homo sapiens_hsa049710.58397148
97Vitamin digestion and absorption_Homo sapiens_hsa049770.57756192
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.57182161
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.56851150
100Salivary secretion_Homo sapiens_hsa049700.56378739
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55298201
102Dorso-ventral axis formation_Homo sapiens_hsa043200.52538015
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52382545
104Ras signaling pathway_Homo sapiens_hsa040140.51827100
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51474199
106Inositol phosphate metabolism_Homo sapiens_hsa005620.51326694
107Hedgehog signaling pathway_Homo sapiens_hsa043400.50001026
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49949550
109ErbB signaling pathway_Homo sapiens_hsa040120.49245892
110Cholinergic synapse_Homo sapiens_hsa047250.48867700
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48475443
112Dopaminergic synapse_Homo sapiens_hsa047280.48071411
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47011878
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46335745
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46277688
116Choline metabolism in cancer_Homo sapiens_hsa052310.45957381
117Lysosome_Homo sapiens_hsa041420.45747579
118MAPK signaling pathway_Homo sapiens_hsa040100.45730243
119Peroxisome_Homo sapiens_hsa041460.45622858
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45438338
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45415079
122Phototransduction_Homo sapiens_hsa047440.45157216
123Pancreatic secretion_Homo sapiens_hsa049720.45131135
124Adherens junction_Homo sapiens_hsa045200.44726486
125Pyruvate metabolism_Homo sapiens_hsa006200.44598765
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43189474
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43022985
128Rheumatoid arthritis_Homo sapiens_hsa053230.42630266
129Autoimmune thyroid disease_Homo sapiens_hsa053200.42614138
130Metabolic pathways_Homo sapiens_hsa011000.39124372
131ECM-receptor interaction_Homo sapiens_hsa045120.39039419
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39004920
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.38555520
134Folate biosynthesis_Homo sapiens_hsa007900.38100473
135Renin secretion_Homo sapiens_hsa049240.37854064
136Phagosome_Homo sapiens_hsa041450.37846383
137Tyrosine metabolism_Homo sapiens_hsa003500.36430416
138Endocytosis_Homo sapiens_hsa041440.36060774
139Retinol metabolism_Homo sapiens_hsa008300.34284437
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34143022
141beta-Alanine metabolism_Homo sapiens_hsa004100.32855157
142Gap junction_Homo sapiens_hsa045400.31735591
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31017626
144Prion diseases_Homo sapiens_hsa050200.28141543
145Fatty acid biosynthesis_Homo sapiens_hsa000610.27664672
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26955658
147Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25981769
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.23874291
149Taste transduction_Homo sapiens_hsa047420.23458606
150Nicotine addiction_Homo sapiens_hsa050330.21244086
151Melanogenesis_Homo sapiens_hsa049160.20740702
152ABC transporters_Homo sapiens_hsa020100.19806671

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