APOC1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)6.61083329
2drug catabolic process (GO:0042737)6.34011688
3glyoxylate metabolic process (GO:0046487)5.75566399
4omega-hydroxylase P450 pathway (GO:0097267)5.19897250
5tryptophan catabolic process (GO:0006569)5.18255802
6indole-containing compound catabolic process (GO:0042436)5.18255802
7indolalkylamine catabolic process (GO:0046218)5.18255802
8aromatic amino acid family catabolic process (GO:0009074)5.08809467
9epoxygenase P450 pathway (GO:0019373)5.07318909
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.98182340
11L-phenylalanine catabolic process (GO:0006559)4.98182340
12cellular ketone body metabolic process (GO:0046950)4.65271888
13tryptophan metabolic process (GO:0006568)4.57255774
14oxidative demethylation (GO:0070989)4.55197451
15S-adenosylmethionine metabolic process (GO:0046500)4.36780099
16regulation of fibrinolysis (GO:0051917)4.35501009
17serine family amino acid catabolic process (GO:0009071)4.22508663
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.21324649
19L-phenylalanine metabolic process (GO:0006558)4.21324649
20ketone body metabolic process (GO:1902224)4.21254256
21indolalkylamine metabolic process (GO:0006586)4.14143632
22water-soluble vitamin biosynthetic process (GO:0042364)4.13754560
23negative regulation of cholesterol transport (GO:0032375)4.07530513
24negative regulation of sterol transport (GO:0032372)4.07530513
25drug metabolic process (GO:0017144)4.04079055
26regulation of triglyceride catabolic process (GO:0010896)4.00688935
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.88241408
28ethanol oxidation (GO:0006069)3.85526134
29bile acid biosynthetic process (GO:0006699)3.83745014
30phenylpropanoid metabolic process (GO:0009698)3.79467315
31aromatic amino acid family metabolic process (GO:0009072)3.77796211
32kynurenine metabolic process (GO:0070189)3.72996351
33negative regulation of fibrinolysis (GO:0051918)3.72593605
34amine catabolic process (GO:0009310)3.71304514
35cellular biogenic amine catabolic process (GO:0042402)3.71304514
36high-density lipoprotein particle remodeling (GO:0034375)3.70751776
37complement activation, alternative pathway (GO:0006957)3.60780228
38L-methionine salvage (GO:0071267)3.54390461
39L-methionine biosynthetic process (GO:0071265)3.54390461
40amino acid salvage (GO:0043102)3.54390461
41aldehyde catabolic process (GO:0046185)3.54359278
42reverse cholesterol transport (GO:0043691)3.51771391
43glycine metabolic process (GO:0006544)3.49907586
44arginine metabolic process (GO:0006525)3.49246240
45phospholipid efflux (GO:0033700)3.46966453
46regulation of protein activation cascade (GO:2000257)3.42546768
47behavioral response to nicotine (GO:0035095)3.39572792
48cholesterol efflux (GO:0033344)3.36736285
49blood coagulation, intrinsic pathway (GO:0007597)3.34200838
50triglyceride homeostasis (GO:0070328)3.33923938
51acylglycerol homeostasis (GO:0055090)3.33923938
52alpha-amino acid catabolic process (GO:1901606)3.27151005
53DNA deamination (GO:0045006)3.26885122
54regulation of complement activation (GO:0030449)3.25826869
55regulation of cholesterol esterification (GO:0010872)3.20116004
56plasma lipoprotein particle remodeling (GO:0034369)3.19639208
57protein-lipid complex remodeling (GO:0034368)3.19639208
58macromolecular complex remodeling (GO:0034367)3.19639208
59pyrimidine nucleobase catabolic process (GO:0006208)3.19118125
60tyrosine metabolic process (GO:0006570)3.18762937
61bile acid metabolic process (GO:0008206)3.17554724
62peptidyl-glutamic acid carboxylation (GO:0017187)3.17286176
63protein carboxylation (GO:0018214)3.17286176
64positive regulation of fatty acid transport (GO:2000193)3.13330058
65glucuronate metabolic process (GO:0019585)3.12425948
66uronic acid metabolic process (GO:0006063)3.12425948
67imidazole-containing compound metabolic process (GO:0052803)3.11432056
68benzene-containing compound metabolic process (GO:0042537)3.10936014
69ethanol metabolic process (GO:0006067)3.08167172
70amino-acid betaine metabolic process (GO:0006577)3.07414461
71positive regulation of icosanoid secretion (GO:0032305)3.06992378
72protein-cofactor linkage (GO:0018065)3.05693969
73fibrinolysis (GO:0042730)3.03810557
74nucleobase catabolic process (GO:0046113)3.02848301
75arginine catabolic process (GO:0006527)3.02528642
76indole-containing compound metabolic process (GO:0042430)3.02096954
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.00971130
78cellular glucuronidation (GO:0052695)3.00925941
79serine family amino acid metabolic process (GO:0009069)3.00255661
80alkaloid metabolic process (GO:0009820)2.96896311
81cellular amino acid catabolic process (GO:0009063)2.95573892
82heme transport (GO:0015886)2.91752318
83xenobiotic catabolic process (GO:0042178)2.90948058
84basic amino acid transport (GO:0015802)2.88251105
85vitamin biosynthetic process (GO:0009110)2.88197195
86piRNA metabolic process (GO:0034587)2.86558625
87dopamine transport (GO:0015872)2.83725916
88response to pheromone (GO:0019236)2.83269557
89peptidyl-glutamic acid modification (GO:0018200)2.81327160
90L-fucose catabolic process (GO:0042355)2.80372203
91fucose catabolic process (GO:0019317)2.80372203
92L-fucose metabolic process (GO:0042354)2.80372203
93respiratory chain complex IV assembly (GO:0008535)2.78645883
94protein complex biogenesis (GO:0070271)2.73793841
95bile acid and bile salt transport (GO:0015721)2.71986430
96methionine biosynthetic process (GO:0009086)2.71331129
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70092744
98methionine metabolic process (GO:0006555)2.64183438
99regulation of lipoprotein particle clearance (GO:0010984)2.62764124
100protein polyglutamylation (GO:0018095)2.61990468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.73110522
2VDR_22108803_ChIP-Seq_LS180_Human3.09911454
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.01997493
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79710013
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60201314
6IGF1R_20145208_ChIP-Seq_DFB_Human2.52524957
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47448834
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.40183301
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32613351
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.30270906
11GBX2_23144817_ChIP-Seq_PC3_Human2.25341412
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21217062
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16430633
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.10812962
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.08369144
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07338593
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.06374947
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99765397
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98043786
20CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.89489416
21IRF1_19129219_ChIP-ChIP_H3396_Human1.79638834
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78223228
23P300_19829295_ChIP-Seq_ESCs_Human1.77503551
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74418187
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70894054
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70887100
27FUS_26573619_Chip-Seq_HEK293_Human1.68679682
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68519562
29TAF15_26573619_Chip-Seq_HEK293_Human1.68121996
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.61200774
31EWS_26573619_Chip-Seq_HEK293_Human1.57935025
32ER_23166858_ChIP-Seq_MCF-7_Human1.57241050
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56950429
34TP53_22573176_ChIP-Seq_HFKS_Human1.51711551
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.50416353
36BCAT_22108803_ChIP-Seq_LS180_Human1.49296594
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.48628976
38NANOG_19829295_ChIP-Seq_ESCs_Human1.45153265
39SOX2_19829295_ChIP-Seq_ESCs_Human1.45153265
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44565887
41HTT_18923047_ChIP-ChIP_STHdh_Human1.44275468
42AR_20517297_ChIP-Seq_VCAP_Human1.42794472
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42550902
44CBP_20019798_ChIP-Seq_JUKART_Human1.42550902
45MYC_18940864_ChIP-ChIP_HL60_Human1.42382020
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40675404
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40453620
48VDR_23849224_ChIP-Seq_CD4+_Human1.39097264
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38837822
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38106415
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.38106415
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.37785192
53ELK1_19687146_ChIP-ChIP_HELA_Human1.35139174
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33250329
55NCOR_22424771_ChIP-Seq_293T_Human1.31867503
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.30892538
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30838086
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30786948
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30560631
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.30110454
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.28186889
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.26625267
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.25941403
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25145259
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22727583
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22600990
67AR_25329375_ChIP-Seq_VCAP_Human1.20990283
68TCF4_22108803_ChIP-Seq_LS180_Human1.20287207
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.19085942
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18606351
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17872310
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16242436
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.16217512
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15721046
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13173634
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.12427868
77FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12276164
78STAT3_23295773_ChIP-Seq_U87_Human1.12204918
79TCF4_23295773_ChIP-Seq_U87_Human1.11782649
80MYC_19829295_ChIP-Seq_ESCs_Human1.11431627
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.10573621
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07568090
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.07174046
84SMAD4_21799915_ChIP-Seq_A2780_Human1.06834151
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.06619202
86RUNX2_22187159_ChIP-Seq_PCA_Human1.06551003
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06014132
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05157414
89CDX2_22108803_ChIP-Seq_LS180_Human1.04934879
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02557642
91FOXP3_21729870_ChIP-Seq_TREG_Human1.01579083
92CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01271706
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00576144
94PHF8_20622853_ChIP-Seq_HELA_Human1.00121804
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99695523
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99573060
97* HOXB7_26014856_ChIP-Seq_BT474_Human0.97896740
98EZH2_22144423_ChIP-Seq_EOC_Human0.97399003
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97150360
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95619455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis5.29515735
2MP0002139_abnormal_hepatobiliary_system4.86948200
3MP0005360_urolithiasis4.64347903
4MP0008875_abnormal_xenobiotic_pharmacok4.34050077
5MP0005085_abnormal_gallbladder_physiolo3.79730206
6MP0005365_abnormal_bile_salt3.33727667
7MP0002138_abnormal_hepatobiliary_system3.17111939
8MP0002876_abnormal_thyroid_physiology2.59434995
9MP0003252_abnormal_bile_duct2.53444723
10MP0010329_abnormal_lipoprotein_level2.33167616
11MP0005332_abnormal_amino_acid2.32259095
12MP0001986_abnormal_taste_sensitivity2.16185289
13MP0008877_abnormal_DNA_methylation2.11168041
14MP0003806_abnormal_nucleotide_metabolis2.08061719
15MP0006292_abnormal_olfactory_placode1.99625492
16MP0008872_abnormal_physiological_respon1.99363012
17MP0005646_abnormal_pituitary_gland1.97271650
18MP0003011_delayed_dark_adaptation1.96387106
19MP0005551_abnormal_eye_electrophysiolog1.96311664
20MP0002102_abnormal_ear_morphology1.93453433
21MP0000372_irregular_coat_pigmentation1.80585614
22MP0001764_abnormal_homeostasis1.79010911
23MP0006072_abnormal_retinal_apoptosis1.75496967
24MP0002837_dystrophic_cardiac_calcinosis1.73713915
25MP0009697_abnormal_copulation1.67739174
26MP0005084_abnormal_gallbladder_morpholo1.67373597
27MP0005645_abnormal_hypothalamus_physiol1.55562885
28MP0001984_abnormal_olfaction1.50392411
29MP0001968_abnormal_touch/_nociception1.50152805
30MP0001666_abnormal_nutrient_absorption1.45218483
31MP0004147_increased_porphyrin_level1.39224309
32MP0005253_abnormal_eye_physiology1.36104775
33MP0002736_abnormal_nociception_after1.28701102
34MP0004885_abnormal_endolymph1.28150144
35MP0003718_maternal_effect1.24623194
36MP0005379_endocrine/exocrine_gland_phen1.23575175
37MP0002938_white_spotting1.22740493
38MP0009745_abnormal_behavioral_response1.19750752
39MP0003186_abnormal_redox_activity1.17201988
40MP0004019_abnormal_vitamin_homeostasis1.16032663
41MP0002638_abnormal_pupillary_reflex1.13303095
42MP0009046_muscle_twitch1.12662004
43MP0003787_abnormal_imprinting1.11951764
44MP0004142_abnormal_muscle_tone1.10394579
45MP0004043_abnormal_pH_regulation1.10314571
46MP0005636_abnormal_mineral_homeostasis1.08456092
47MP0004133_heterotaxia1.08145191
48MP0009840_abnormal_foam_cell1.07159981
49MP0005075_abnormal_melanosome_morpholog1.07066935
50MP0002118_abnormal_lipid_homeostasis1.06293296
51MP0006036_abnormal_mitochondrial_physio1.03327151
52MP0003878_abnormal_ear_physiology1.00744338
53MP0005377_hearing/vestibular/ear_phenot1.00744338
54MP0002909_abnormal_adrenal_gland1.00411727
55MP0003646_muscle_fatigue0.96969058
56MP0002272_abnormal_nervous_system0.96917054
57MP0001501_abnormal_sleep_pattern0.95339217
58MP0002928_abnormal_bile_duct0.93178489
59MP0006276_abnormal_autonomic_nervous0.92796325
60MP0000609_abnormal_liver_physiology0.91135045
61MP0002653_abnormal_ependyma_morphology0.89220609
62MP0000427_abnormal_hair_cycle0.87222787
63MP0001486_abnormal_startle_reflex0.86057061
64MP0003868_abnormal_feces_composition0.85744051
65MP0009764_decreased_sensitivity_to0.85345207
66MP0002163_abnormal_gland_morphology0.84546486
67MP0005319_abnormal_enzyme/_coenzyme0.84524876
68MP0003136_yellow_coat_color0.81882319
69MP0005389_reproductive_system_phenotype0.79495438
70MP0009643_abnormal_urine_homeostasis0.77633327
71MP0001324_abnormal_eye_pigmentation0.76830150
72MP0001485_abnormal_pinna_reflex0.76231859
73MP0005410_abnormal_fertilization0.75812235
74MP0010386_abnormal_urinary_bladder0.74074775
75MP0008058_abnormal_DNA_repair0.73873646
76MP0008995_early_reproductive_senescence0.73830330
77MP0000631_abnormal_neuroendocrine_gland0.72586583
78MP0002557_abnormal_social/conspecific_i0.71182982
79MP0008775_abnormal_heart_ventricle0.70979798
80MP0000569_abnormal_digit_pigmentation0.70604151
81MP0005395_other_phenotype0.70287972
82MP0002064_seizures0.69715834
83MP0000647_abnormal_sebaceous_gland0.69546514
84MP0001919_abnormal_reproductive_system0.69255796
85MP0002733_abnormal_thermal_nociception0.69133678
86MP0005167_abnormal_blood-brain_barrier0.69079826
87MP0002234_abnormal_pharynx_morphology0.67918206
88MP0005174_abnormal_tail_pigmentation0.67394278
89MP0002282_abnormal_trachea_morphology0.67071005
90MP0004215_abnormal_myocardial_fiber0.66669998
91MP0003121_genomic_imprinting0.66622822
92MP0005195_abnormal_posterior_eye0.66618225
93MP0000230_abnormal_systemic_arterial0.65359264
94MP0005386_behavior/neurological_phenoty0.64097627
95MP0004924_abnormal_behavior0.64097627
96MP0002090_abnormal_vision0.63840464
97MP0001905_abnormal_dopamine_level0.63333408
98MP0000639_abnormal_adrenal_gland0.63184499
99MP0005408_hypopigmentation0.62730146
100MP0003122_maternal_imprinting0.62249389

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)4.35343713
2Hyperglycinemia (HP:0002154)3.74543450
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.68178034
4Delayed CNS myelination (HP:0002188)3.65975976
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.62668664
6Pancreatic cysts (HP:0001737)3.51820615
7Complement deficiency (HP:0004431)3.21930788
8Hypobetalipoproteinemia (HP:0003563)3.19986174
9Pancreatic fibrosis (HP:0100732)3.13418666
10Congenital stationary night blindness (HP:0007642)3.03174927
11True hermaphroditism (HP:0010459)3.01586547
12Acute encephalopathy (HP:0006846)3.01192146
13Deep venous thrombosis (HP:0002625)2.99509496
14Abnormality of glycine metabolism (HP:0010895)2.98113205
15Abnormality of serine family amino acid metabolism (HP:0010894)2.98113205
16Renal cortical cysts (HP:0000803)2.81531605
17Hyperglycinuria (HP:0003108)2.79951756
18Nephronophthisis (HP:0000090)2.79943230
19Generalized aminoaciduria (HP:0002909)2.78740645
20Acute necrotizing encephalopathy (HP:0006965)2.78392937
21Abnormality of the renal cortex (HP:0011035)2.78066249
22Molar tooth sign on MRI (HP:0002419)2.76987154
23Abnormality of midbrain morphology (HP:0002418)2.76987154
24Hypothermia (HP:0002045)2.76038153
25Abnormality of serum amino acid levels (HP:0003112)2.72831974
26Hepatic necrosis (HP:0002605)2.72115174
27Joint hemorrhage (HP:0005261)2.71235274
28Ketosis (HP:0001946)2.68160769
29Increased CSF lactate (HP:0002490)2.65347533
30Mitochondrial inheritance (HP:0001427)2.64398711
31Abnormal biliary tract physiology (HP:0012439)2.63911997
32Bile duct proliferation (HP:0001408)2.63911997
33Glycosuria (HP:0003076)2.59102784
34Abnormality of urine glucose concentration (HP:0011016)2.59102784
35Conjugated hyperbilirubinemia (HP:0002908)2.57702025
36Hepatocellular necrosis (HP:0001404)2.55883610
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54905268
38Progressive macrocephaly (HP:0004481)2.54253662
39Abnormality of pyrimidine metabolism (HP:0004353)2.53420126
40Decreased central vision (HP:0007663)2.52140390
41Type II lissencephaly (HP:0007260)2.51394861
42Cerebral edema (HP:0002181)2.48414369
43Abolished electroretinogram (ERG) (HP:0000550)2.45199346
44Lethargy (HP:0001254)2.44858171
45Methylmalonic acidemia (HP:0002912)2.40731965
46Abnormality of methionine metabolism (HP:0010901)2.39735831
47Abnormal mitochondria in muscle tissue (HP:0008316)2.39009587
48Fair hair (HP:0002286)2.37812652
49Abnormality of the renal medulla (HP:0100957)2.36154578
50Xanthomatosis (HP:0000991)2.34892044
51Hyperlipoproteinemia (HP:0010980)2.29579160
52Medial flaring of the eyebrow (HP:0010747)2.28816407
53Attenuation of retinal blood vessels (HP:0007843)2.25701323
54Pendular nystagmus (HP:0012043)2.20757428
55Methylmalonic aciduria (HP:0012120)2.19988537
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.17791062
57Abnormality of alanine metabolism (HP:0010916)2.17791062
58Hyperalaninemia (HP:0003348)2.17791062
59Spontaneous abortion (HP:0005268)2.17677010
60Systemic lupus erythematosus (HP:0002725)2.14088702
61Increased serum lactate (HP:0002151)2.12419830
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12236170
63Intrahepatic cholestasis (HP:0001406)2.09360583
64Cystic liver disease (HP:0006706)2.09194764
65Ketoacidosis (HP:0001993)2.06722528
66Abnormal rod and cone electroretinograms (HP:0008323)2.05339062
67Metabolic acidosis (HP:0001942)2.00027278
68Hypomagnesemia (HP:0002917)1.99827111
69Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98685216
70Optic disc pallor (HP:0000543)1.98534423
71Large for gestational age (HP:0001520)1.98259559
72Sclerocornea (HP:0000647)1.97093585
73Polydipsia (HP:0001959)1.95518994
74Abnormal drinking behavior (HP:0030082)1.95518994
75Abnormality of complement system (HP:0005339)1.94534411
76Chronic hepatic failure (HP:0100626)1.93744832
77Hyperammonemia (HP:0001987)1.92507146
78Hyperventilation (HP:0002883)1.91779783
79Lactic acidosis (HP:0003128)1.91327896
80Cerebral palsy (HP:0100021)1.91250474
81Aplasia/hypoplasia of the uterus (HP:0008684)1.87352614
82Lipid accumulation in hepatocytes (HP:0006561)1.84397736
83Arthropathy (HP:0003040)1.83996972
84Male pseudohermaphroditism (HP:0000037)1.82615266
85Abnormality of sulfur amino acid metabolism (HP:0004339)1.81911729
86Hypoglycemic coma (HP:0001325)1.78879765
87CNS demyelination (HP:0007305)1.78476712
88Progressive inability to walk (HP:0002505)1.78003642
893-Methylglutaconic aciduria (HP:0003535)1.75538181
90Hyperphosphaturia (HP:0003109)1.74599473
91Dicarboxylic aciduria (HP:0003215)1.73735560
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73735560
93Gait imbalance (HP:0002141)1.72496574
94Keratoconus (HP:0000563)1.72487628
95Increased corneal curvature (HP:0100692)1.72487628
96Stomach cancer (HP:0012126)1.72268949
97Inability to walk (HP:0002540)1.71390466
98Congenital hepatic fibrosis (HP:0002612)1.69646960
99Generalized hypopigmentation of hair (HP:0011358)1.69614352
100Congenital primary aphakia (HP:0007707)1.69421269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.44788459
2MAP4K23.25884080
3TAOK33.25545234
4WNK32.76139153
5NUAK12.75251747
6ADRBK22.60831727
7WNK42.60210221
8MAP3K122.52027612
9ZAK2.46870310
10GRK12.33993034
11BMPR1B2.27487240
12BCKDK1.96282844
13STK391.85443717
14TLK11.81506985
15TRIM281.73053084
16TXK1.65933185
17PINK11.64831649
18VRK21.61467621
19OXSR11.58488449
20INSRR1.51991465
21MAP3K41.49619829
22CASK1.48328745
23MAPK131.47328925
24EIF2AK31.38089908
25TIE11.37733096
26ACVR1B1.28178341
27TNIK1.24457204
28MUSK1.24311106
29STK161.22834734
30MST41.21447974
31ERBB31.10258337
32VRK11.09941262
33PRKCG1.06739796
34PHKG21.05704966
35PHKG11.05704966
36DYRK21.04167900
37CSNK1G31.00222985
38DAPK21.00106774
39EIF2AK10.98364102
40PLK20.98187011
41CSNK1G10.93480881
42PAK30.91843740
43CSNK1G20.90228793
44MKNK20.88475058
45PRKCE0.88469981
46MAP2K70.87924952
47PLK30.83201130
48PDK20.82024317
49EPHA40.80979361
50MAP2K40.80102045
51BRSK20.79681812
52IKBKB0.73514142
53FGFR20.70872342
54CSNK1A1L0.68336808
55PIK3CA0.66628712
56BUB10.64418623
57TGFBR10.63102416
58ADRBK10.62945435
59KIT0.61162374
60NME10.61015927
61BCR0.60822123
62PRKCQ0.59726304
63MAPKAPK30.57734811
64MARK10.57422687
65PLK40.57278660
66EIF2AK20.56375115
67PRKACA0.54913418
68GRK70.54424596
69SRPK10.53701156
70FER0.52854049
71CSNK1A10.51425972
72TEC0.51093358
73NEK10.50458658
74PBK0.49789323
75CCNB10.49702953
76DAPK10.48815021
77MAP2K60.48174470
78GRK50.47556438
79WEE10.45287940
80PRKCI0.44863556
81PLK10.43643646
82PRKCA0.43286098
83IGF1R0.42856961
84PRKACG0.41399969
85CSNK1D0.41368436
86MAP2K20.41295812
87ATR0.41033286
88CAMKK20.40812361
89RPS6KA50.40534064
90MKNK10.39120176
91TNK20.39031379
92GRK60.38294004
93PRKG10.38052206
94NTRK30.37873811
95PIK3CG0.37721366
96CSNK2A10.37512598
97PRKAA20.37117304
98STK38L0.35645873
99PKN10.35032969
100LIMK10.34844842

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.46429836
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.12014016
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.74910891
4Retinol metabolism_Homo sapiens_hsa008302.69429589
5Butanoate metabolism_Homo sapiens_hsa006502.48272290
6Chemical carcinogenesis_Homo sapiens_hsa052042.46439729
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42518962
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36134890
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.33026064
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.31806650
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.28838878
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.25223128
13Complement and coagulation cascades_Homo sapiens_hsa046102.19960446
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19361680
15Tryptophan metabolism_Homo sapiens_hsa003802.16058832
16Linoleic acid metabolism_Homo sapiens_hsa005912.12120427
17Fatty acid degradation_Homo sapiens_hsa000712.07196053
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.00974490
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98660419
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88750090
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.82601012
22Peroxisome_Homo sapiens_hsa041461.68591734
23Oxidative phosphorylation_Homo sapiens_hsa001901.62005871
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.60296141
25Tyrosine metabolism_Homo sapiens_hsa003501.52449269
26Arginine biosynthesis_Homo sapiens_hsa002201.49444585
27Propanoate metabolism_Homo sapiens_hsa006401.48790437
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.46143148
29Arachidonic acid metabolism_Homo sapiens_hsa005901.36257805
30Protein export_Homo sapiens_hsa030601.35012047
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33829353
32Histidine metabolism_Homo sapiens_hsa003401.32860026
33One carbon pool by folate_Homo sapiens_hsa006701.31823685
34Phototransduction_Homo sapiens_hsa047441.30512976
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30072211
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25969375
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.24667263
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24168579
39Selenocompound metabolism_Homo sapiens_hsa004501.22346536
40Phenylalanine metabolism_Homo sapiens_hsa003601.18300202
41Parkinsons disease_Homo sapiens_hsa050121.17726829
42Proteasome_Homo sapiens_hsa030501.16417602
43beta-Alanine metabolism_Homo sapiens_hsa004101.15044182
44Sulfur metabolism_Homo sapiens_hsa009201.14036392
45RNA polymerase_Homo sapiens_hsa030201.09398674
46Nitrogen metabolism_Homo sapiens_hsa009101.06822247
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00033653
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95983416
49Homologous recombination_Homo sapiens_hsa034400.94692691
50Fat digestion and absorption_Homo sapiens_hsa049750.90209915
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87599024
52ABC transporters_Homo sapiens_hsa020100.85797976
53Pyruvate metabolism_Homo sapiens_hsa006200.84410149
54Fatty acid metabolism_Homo sapiens_hsa012120.83471349
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82907399
56Bile secretion_Homo sapiens_hsa049760.81773643
57Fatty acid elongation_Homo sapiens_hsa000620.81652937
58Metabolic pathways_Homo sapiens_hsa011000.81623583
59Starch and sucrose metabolism_Homo sapiens_hsa005000.81119343
60Arginine and proline metabolism_Homo sapiens_hsa003300.78397984
61Basal transcription factors_Homo sapiens_hsa030220.77942228
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75726343
63PPAR signaling pathway_Homo sapiens_hsa033200.75449724
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.74418355
65Fanconi anemia pathway_Homo sapiens_hsa034600.72751774
66RNA degradation_Homo sapiens_hsa030180.72207523
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71404799
68Staphylococcus aureus infection_Homo sapiens_hsa051500.63014982
69Ether lipid metabolism_Homo sapiens_hsa005650.62980498
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60685097
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60394126
72Huntingtons disease_Homo sapiens_hsa050160.60369102
73Steroid biosynthesis_Homo sapiens_hsa001000.58572468
74Nicotine addiction_Homo sapiens_hsa050330.58000250
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56931301
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.56405660
77Alzheimers disease_Homo sapiens_hsa050100.55876385
78Collecting duct acid secretion_Homo sapiens_hsa049660.55706084
79Glutathione metabolism_Homo sapiens_hsa004800.48167809
80Pyrimidine metabolism_Homo sapiens_hsa002400.46870023
81Vitamin B6 metabolism_Homo sapiens_hsa007500.46064722
82Folate biosynthesis_Homo sapiens_hsa007900.44273715
83Glycerolipid metabolism_Homo sapiens_hsa005610.44167946
84Asthma_Homo sapiens_hsa053100.41071275
85Non-homologous end-joining_Homo sapiens_hsa034500.40854420
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40434942
87Regulation of autophagy_Homo sapiens_hsa041400.39660612
88Serotonergic synapse_Homo sapiens_hsa047260.38679181
89Purine metabolism_Homo sapiens_hsa002300.36715418
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36636294
91Mineral absorption_Homo sapiens_hsa049780.35823609
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35474261
93Cardiac muscle contraction_Homo sapiens_hsa042600.33438230
94Sulfur relay system_Homo sapiens_hsa041220.32319497
95Biosynthesis of amino acids_Homo sapiens_hsa012300.32271315
96Carbon metabolism_Homo sapiens_hsa012000.31967271
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29565003
98Taste transduction_Homo sapiens_hsa047420.29443953
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28963669
100Olfactory transduction_Homo sapiens_hsa047400.28517063

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