APOBEC3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid segregation (GO:0000070)5.01030787
2mitotic chromosome condensation (GO:0007076)4.72478191
3establishment of integrated proviral latency (GO:0075713)4.59368719
4sister chromatid segregation (GO:0000819)4.48502404
5DNA strand elongation involved in DNA replication (GO:0006271)4.48231470
6telomere maintenance via semi-conservative replication (GO:0032201)4.48217836
7protein localization to chromosome, centromeric region (GO:0071459)4.40330234
8mitotic metaphase plate congression (GO:0007080)4.34291395
9DNA strand elongation (GO:0022616)4.33995347
10proteasome assembly (GO:0043248)4.14917651
11protein localization to kinetochore (GO:0034501)4.13343929
12establishment of viral latency (GO:0019043)4.05428287
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.05301501
14anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.95285732
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.92818283
16mitotic nuclear envelope disassembly (GO:0007077)3.91100275
17deoxyribonucleotide biosynthetic process (GO:0009263)3.88002168
18DNA unwinding involved in DNA replication (GO:0006268)3.85757472
19regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.84366667
20telomere maintenance via recombination (GO:0000722)3.81524704
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.74785812
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.73720884
23regulation of spindle organization (GO:0090224)3.67038751
24nucleobase-containing small molecule interconversion (GO:0015949)3.66935157
25nuclear envelope disassembly (GO:0051081)3.62213178
26membrane disassembly (GO:0030397)3.62213178
27negative regulation of ligase activity (GO:0051352)3.62163241
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.62163241
29metaphase plate congression (GO:0051310)3.61537087
30Golgi transport vesicle coating (GO:0048200)3.60628191
31COPI coating of Golgi vesicle (GO:0048205)3.60628191
32mitotic recombination (GO:0006312)3.60441889
33nuclear pore complex assembly (GO:0051292)3.58647108
34regulation of mitotic spindle organization (GO:0060236)3.55816266
35establishment of chromosome localization (GO:0051303)3.54912783
36folic acid-containing compound biosynthetic process (GO:0009396)3.43930532
37kinetochore organization (GO:0051383)3.35726957
38DNA topological change (GO:0006265)3.32754930
39DNA ligation (GO:0006266)3.29543479
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27338672
41signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23322940
42intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23322940
43DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.22268090
44ribosome assembly (GO:0042255)3.22197091
45signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.21296446
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.21296446
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.21296446
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19949436
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.19949436
50positive regulation of ligase activity (GO:0051351)3.19602324
51IMP biosynthetic process (GO:0006188)3.19326050
52DNA replication initiation (GO:0006270)3.17500709
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.16929861
54chromosome segregation (GO:0007059)3.15755869
55chromosome condensation (GO:0030261)3.13795123
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10947235
57signal transduction involved in cell cycle checkpoint (GO:0072395)3.10273821
58regulation of cellular amino acid metabolic process (GO:0006521)3.10115732
59regulation of chromosome segregation (GO:0051983)3.08714602
60regulation of ubiquitin-protein transferase activity (GO:0051438)3.07356363
61CENP-A containing nucleosome assembly (GO:0034080)3.03020854
62spindle checkpoint (GO:0031577)3.02707601
63nuclear pore organization (GO:0006999)3.02688411
64regulation of ligase activity (GO:0051340)3.01710606
65antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.01526993
66positive regulation of chromosome segregation (GO:0051984)3.00058033
67mitotic nuclear envelope reassembly (GO:0007084)2.99922497
68nuclear envelope reassembly (GO:0031468)2.99922497
69DNA replication checkpoint (GO:0000076)2.98665137
70G1/S transition of mitotic cell cycle (GO:0000082)2.97931151
71cell cycle G1/S phase transition (GO:0044843)2.97931151
72formation of translation preinitiation complex (GO:0001731)2.94978867
73telomere maintenance via telomere lengthening (GO:0010833)2.94749572
74protoporphyrinogen IX metabolic process (GO:0046501)2.94153492
75nucleotide-excision repair, DNA gap filling (GO:0006297)2.93383840
76deoxyribose phosphate biosynthetic process (GO:0046385)2.89033419
772-deoxyribonucleotide biosynthetic process (GO:0009265)2.89033419
78nuclear envelope organization (GO:0006998)2.86745446
79negative regulation of chromosome segregation (GO:0051985)2.86670728
80pore complex assembly (GO:0046931)2.85929460
81mitotic spindle checkpoint (GO:0071174)2.85917264
82kinetochore assembly (GO:0051382)2.83644290
83protein maturation by protein folding (GO:0022417)2.82090460
84pentose-phosphate shunt (GO:0006098)2.78432632
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77604920
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.77604920
87negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77604920
88negative regulation of mitotic sister chromatid separation (GO:2000816)2.77604920
89negative regulation of sister chromatid segregation (GO:0033046)2.77604920
90purine nucleobase biosynthetic process (GO:0009113)2.76829584
91IMP metabolic process (GO:0046040)2.76451295
92mitotic spindle assembly checkpoint (GO:0007094)2.75860322
93chromatin remodeling at centromere (GO:0031055)2.74612804
94mitotic cell cycle (GO:0000278)2.73384915
95viral mRNA export from host cell nucleus (GO:0046784)2.73296992
96regulation of exit from mitosis (GO:0007096)2.71079014
97spindle assembly checkpoint (GO:0071173)2.71028438
98DNA packaging (GO:0006323)2.70755345
99regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68517944
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.68517944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.17994440
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.93172431
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.69124078
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68418803
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44123177
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.08912323
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05574037
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.48779585
9AR_21909140_ChIP-Seq_LNCAP_Human2.47613405
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45681369
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40714462
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27906320
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27879527
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27795598
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16708727
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14796467
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.14490896
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12274559
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05545785
20DCP1A_22483619_ChIP-Seq_HELA_Human1.96615141
21E2F1_21310950_ChIP-Seq_MCF-7_Human1.94214236
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.92840513
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92491985
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.89514947
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.88626659
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83544431
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82784671
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77411763
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70638581
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66955573
31XRN2_22483619_ChIP-Seq_HELA_Human1.66081133
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64613926
33MYC_22102868_ChIP-Seq_BL_Human1.63822320
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61191210
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58995993
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52657270
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52441620
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48805180
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48640693
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47395242
41GABP_19822575_ChIP-Seq_HepG2_Human1.47328702
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46434653
43HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.44219584
44FOXP3_21729870_ChIP-Seq_TREG_Human1.43586576
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41800274
46VDR_23849224_ChIP-Seq_CD4+_Human1.40416083
47ELK1_19687146_ChIP-ChIP_HELA_Human1.38934159
48GATA1_22025678_ChIP-Seq_K562_Human1.37561951
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.37375750
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36899040
51TFEB_21752829_ChIP-Seq_HELA_Human1.36736407
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36030160
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34916635
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34374311
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33381386
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32050345
57ZNF263_19887448_ChIP-Seq_K562_Human1.31041756
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29490190
59TTF2_22483619_ChIP-Seq_HELA_Human1.26797303
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25527242
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25446064
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24815660
63KDM5A_27292631_Chip-Seq_BREAST_Human1.21522962
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21275697
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21260215
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20684894
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20189067
68VDR_21846776_ChIP-Seq_THP-1_Human1.19679139
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18126629
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17028677
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14118327
72SPI1_23547873_ChIP-Seq_NB4_Human1.13304822
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13258867
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.12686286
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11555734
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09620854
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07677907
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06221901
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06080185
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04968288
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04906699
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04758931
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02048761
84CIITA_25753668_ChIP-Seq_RAJI_Human1.02044886
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01084327
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00799124
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00384320
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00152073
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98413866
90* ATF3_27146783_Chip-Seq_COLON_Human0.98361428
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98272146
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97943637
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94310847
94MAF_26560356_Chip-Seq_TH1_Human0.93378112
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92738748
96NCOR1_26117541_ChIP-Seq_K562_Human0.92624972
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92500504
98BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92304568
99* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91943950
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91137777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.55542800
2MP0003111_abnormal_nucleus_morphology4.14170042
3MP0003693_abnormal_embryo_hatching3.92554390
4MP0004957_abnormal_blastocyst_morpholog3.37481376
5MP0003077_abnormal_cell_cycle3.31691241
6MP0002877_abnormal_melanocyte_morpholog3.24286111
7MP0003806_abnormal_nucleotide_metabolis3.19548488
8MP0008058_abnormal_DNA_repair2.66496582
9MP0008007_abnormal_cellular_replicative2.41553946
10MP0008057_abnormal_DNA_replication2.22508172
11MP0008932_abnormal_embryonic_tissue2.05259714
12MP0002396_abnormal_hematopoietic_system2.03693803
13MP0003786_premature_aging1.93224198
14MP0003950_abnormal_plasma_membrane1.92931903
15MP0005451_abnormal_body_composition1.87392527
16MP0003656_abnormal_erythrocyte_physiolo1.81981551
17MP0000350_abnormal_cell_proliferation1.80036481
18MP0000685_abnormal_immune_system1.74451437
19MP0010352_gastrointestinal_tract_polyps1.73223217
20MP0005408_hypopigmentation1.70269854
21MP0009697_abnormal_copulation1.70142203
22MP0000015_abnormal_ear_pigmentation1.68334888
23MP0001730_embryonic_growth_arrest1.65114968
24MP0001835_abnormal_antigen_presentation1.63218870
25MP0003566_abnormal_cell_adhesion1.62947929
26MP0003186_abnormal_redox_activity1.55979823
27MP0001853_heart_inflammation1.54793242
28MP0000858_altered_metastatic_potential1.50251281
29MP0010234_abnormal_vibrissa_follicle1.45928013
30MP0010307_abnormal_tumor_latency1.45250344
31MP0000313_abnormal_cell_death1.44656381
32MP0002019_abnormal_tumor_incidence1.44507740
33MP0009333_abnormal_splenocyte_physiolog1.43252168
34MP0000372_irregular_coat_pigmentation1.41876169
35MP0002166_altered_tumor_susceptibility1.36992213
36MP0003191_abnormal_cellular_cholesterol1.31811955
37MP0005058_abnormal_lysosome_morphology1.29018549
38MP0006035_abnormal_mitochondrial_morpho1.28662900
39MP0000358_abnormal_cell_content/1.28477017
40MP0002398_abnormal_bone_marrow1.28461721
41MP0002080_prenatal_lethality1.25353822
42MP0003763_abnormal_thymus_physiology1.23379644
43MP0001697_abnormal_embryo_size1.20440073
44MP0003718_maternal_effect1.19403831
45MP0006036_abnormal_mitochondrial_physio1.18610341
46MP0005464_abnormal_platelet_physiology1.16670417
47MP0004808_abnormal_hematopoietic_stem1.16612793
48MP0002006_tumorigenesis1.16122334
49MP0005501_abnormal_skin_physiology1.15420335
50MP0003705_abnormal_hypodermis_morpholog1.14647928
51MP0002722_abnormal_immune_system1.14243518
52MP0003941_abnormal_skin_development1.12306052
53MP0000490_abnormal_crypts_of1.10952664
54MP0003436_decreased_susceptibility_to1.09946098
55MP0002429_abnormal_blood_cell1.08868632
56MP0002452_abnormal_antigen_presenting1.07477498
57MP0000703_abnormal_thymus_morphology1.06823846
58MP0002148_abnormal_hypersensitivity_rea1.06570887
59MP0004233_abnormal_muscle_weight1.06411470
60MP0003300_gastrointestinal_ulcer1.06198051
61MP0000689_abnormal_spleen_morphology1.05853862
62MP0002132_abnormal_respiratory_system1.05525110
63MP0001790_abnormal_immune_system1.04405933
64MP0005387_immune_system_phenotype1.04405933
65MP0001672_abnormal_embryogenesis/_devel1.03972730
66MP0005380_embryogenesis_phenotype1.03972730
67MP0009785_altered_susceptibility_to1.03804813
68MP0005025_abnormal_response_to1.02236051
69MP0005621_abnormal_cell_physiology1.01664361
70MP0005000_abnormal_immune_tolerance1.00332192
71MP0005330_cardiomyopathy0.99111544
72MP0008260_abnormal_autophagy0.97916445
73MP0001819_abnormal_immune_cell0.96896723
74MP0002420_abnormal_adaptive_immunity0.96735052
75MP0001800_abnormal_humoral_immune0.96463911
76MP0005384_cellular_phenotype0.94145383
77MP0002723_abnormal_immune_serum0.93401807
78MP0003984_embryonic_growth_retardation0.92654689
79MP0000716_abnormal_immune_system0.92648247
80MP0002796_impaired_skin_barrier0.92300824
81MP0005075_abnormal_melanosome_morpholog0.91934775
82MP0005671_abnormal_response_to0.90718476
83MP0004947_skin_inflammation0.90587247
84MP0001873_stomach_inflammation0.89761735
85MP0005076_abnormal_cell_differentiation0.89706104
86MP0002086_abnormal_extraembryonic_tissu0.89266396
87MP0000371_diluted_coat_color0.88768812
88MP0002060_abnormal_skin_morphology0.88666430
89MP0001348_abnormal_lacrimal_gland0.88479409
90MP0003221_abnormal_cardiomyocyte_apopto0.87587434
91MP0005397_hematopoietic_system_phenotyp0.87376615
92MP0001545_abnormal_hematopoietic_system0.87376615
93MP0002088_abnormal_embryonic_growth/wei0.87182695
94MP0001881_abnormal_mammary_gland0.86953740
95MP0004264_abnormal_extraembryonic_tissu0.85681957
96MP0000569_abnormal_digit_pigmentation0.85306465
97MP0003453_abnormal_keratinocyte_physiol0.84784995
98MP0002419_abnormal_innate_immunity0.84143339
99MP0001216_abnormal_epidermal_layer0.80485183
100MP0001727_abnormal_embryo_implantation0.79810389

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)4.35194527
2Cholecystitis (HP:0001082)4.35194527
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.06092039
4Chromsome breakage (HP:0040012)3.76691971
5Abnormality of glycolysis (HP:0004366)3.22927958
6Rough bone trabeculation (HP:0100670)3.04333709
7Abnormality of the preputium (HP:0100587)3.03119102
8Abnormality of the heme biosynthetic pathway (HP:0010472)2.90121647
9Increased serum pyruvate (HP:0003542)2.84215597
10Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75351815
11Hypertensive crisis (HP:0100735)2.71470792
12Squamous cell carcinoma (HP:0002860)2.68861202
13Cholelithiasis (HP:0001081)2.64179419
14Onycholysis (HP:0001806)2.58426653
15Duodenal stenosis (HP:0100867)2.54263009
16Small intestinal stenosis (HP:0012848)2.54263009
17Reticulocytosis (HP:0001923)2.54070297
18Myelodysplasia (HP:0002863)2.47773316
19Orthostatic hypotension (HP:0001278)2.47237444
20Hypokinesia (HP:0002375)2.40304531
21Abnormal trabecular bone morphology (HP:0100671)2.35997547
22Abnormal gallbladder morphology (HP:0012437)2.33057865
23Abnormality of chromosome stability (HP:0003220)2.31683450
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.31180223
25Osteolytic defects of the hand bones (HP:0009699)2.31180223
26Trismus (HP:0000211)2.28357844
27Hepatosplenomegaly (HP:0001433)2.25857822
28Abnormality of the umbilical cord (HP:0010881)2.24619418
29Meckel diverticulum (HP:0002245)2.21546406
30Abnormality of reticulocytes (HP:0004312)2.18444665
31Increased nuchal translucency (HP:0010880)2.18428807
32Birth length less than 3rd percentile (HP:0003561)2.18396179
33Increased connective tissue (HP:0009025)2.17969265
34Pancytopenia (HP:0001876)2.17356782
35Petechiae (HP:0000967)2.16594242
36Sparse eyelashes (HP:0000653)2.16151627
37Abnormality of T cell physiology (HP:0011840)2.15443259
38Microvesicular hepatic steatosis (HP:0001414)2.12612559
39Reduced antithrombin III activity (HP:0001976)2.12431697
40Progressive muscle weakness (HP:0003323)2.11723285
41Type I transferrin isoform profile (HP:0003642)2.10457997
42Gastrointestinal stroma tumor (HP:0100723)2.08344333
43Upper limb muscle weakness (HP:0003484)2.06991574
44IgA deficiency (HP:0002720)2.06589073
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.05334488
46Ragged-red muscle fibers (HP:0003200)2.04156562
47Entropion (HP:0000621)2.02091714
48Abnormality of the anterior horn cell (HP:0006802)2.01448383
49Degeneration of anterior horn cells (HP:0002398)2.01448383
50Abnormality of the ileum (HP:0001549)1.99507622
51Albinism (HP:0001022)1.98078752
52Reduced subcutaneous adipose tissue (HP:0003758)1.97173319
53Abnormality of the gallbladder (HP:0005264)1.93693676
54Abnormalities of placenta or umbilical cord (HP:0001194)1.93604478
55Bone marrow hypocellularity (HP:0005528)1.89895473
56Selective tooth agenesis (HP:0001592)1.87865700
57Recurrent viral infections (HP:0004429)1.86852449
58Polycythemia (HP:0001901)1.85725037
59IgM deficiency (HP:0002850)1.85321057
60Urticaria (HP:0001025)1.84218896
61Secondary amenorrhea (HP:0000869)1.81039721
62Multiple enchondromatosis (HP:0005701)1.78789757
63Rhabdomyolysis (HP:0003201)1.78762661
64Poikiloderma (HP:0001029)1.77583668
65Hypopigmented skin patches (HP:0001053)1.76966367
66Proximal placement of thumb (HP:0009623)1.76717486
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76225006
68Abnormal protein N-linked glycosylation (HP:0012347)1.76225006
69Abnormal protein glycosylation (HP:0012346)1.76225006
70Abnormal glycosylation (HP:0012345)1.76225006
71Cafe-au-lait spot (HP:0000957)1.75967674
72Deviation of the thumb (HP:0009603)1.74496782
73Abnormal lung lobation (HP:0002101)1.73770919
74Premature graying of hair (HP:0002216)1.73586123
75Lymphoma (HP:0002665)1.73230219
76Progressive hearing impairment (HP:0001730)1.73216781
77Abnormality of methionine metabolism (HP:0010901)1.72809357
78Abnormal umbilical cord blood vessels (HP:0011403)1.72477690
79Single umbilical artery (HP:0001195)1.72477690
80Abnormality of the fetal cardiovascular system (HP:0010948)1.72477690
81Abnormality of the duodenum (HP:0002246)1.70633949
82Hyperbilirubinemia (HP:0002904)1.70353169
83Cellulitis (HP:0100658)1.69884667
84Abnormality of placental membranes (HP:0011409)1.69386073
85Amniotic constriction ring (HP:0009775)1.69386073
86Esophageal neoplasm (HP:0100751)1.67291157
87Neoplasm of head and neck (HP:0012288)1.67291157
88Nonimmune hydrops fetalis (HP:0001790)1.66590976
89Abnormal platelet function (HP:0011869)1.66587945
90Impaired platelet aggregation (HP:0003540)1.66587945
91Nephroblastoma (Wilms tumor) (HP:0002667)1.65958314
92Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64111181
93Micronodular cirrhosis (HP:0001413)1.63874779
94Chronic obstructive pulmonary disease (HP:0006510)1.63440961
95Obstructive lung disease (HP:0006536)1.63440961
96Abnormality of macrophages (HP:0004311)1.62583752
97Aplastic anemia (HP:0001915)1.62130918
98Decreased activity of mitochondrial respiratory chain (HP:0008972)1.62116464
99Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.62116464
100Aplasia/Hypoplasia of the thymus (HP:0010515)1.61387823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.32313683
2EIF2AK13.98298763
3VRK23.11578986
4NME23.11148292
5NEK12.81204541
6EIF2AK32.41345259
7TTK2.40842170
8IRAK32.33145706
9MST1R2.21582682
10WEE12.21507408
11SMG12.16569176
12CDC72.16268912
13MST42.11926605
14PBK2.08275904
15CCNB12.07811779
16EPHA21.99209983
17STK101.92174518
18TESK21.84336531
19SCYL21.75703535
20PAK41.75164472
21VRK11.71328223
22BRSK11.67791138
23SIK31.58478396
24ERN11.50134698
25BRSK21.48851289
26MAP3K81.47652082
27PLK31.43103106
28TESK11.40152985
29SRPK11.35848491
30TSSK61.31598154
31PLK41.30101990
32PLK11.26966414
33AURKB1.24866166
34NME11.18985470
35AURKA1.14001373
36IRAK41.13336982
37CHEK21.09451498
38ZAK1.09151467
39NEK21.07939021
40PDK21.07378704
41EIF2AK21.03652730
42STK41.00818365
43CDK70.99975628
44TAOK20.98877528
45PRPF4B0.97830381
46MAP3K120.97014230
47MAP3K30.87574866
48STK160.86346376
49CLK10.86299824
50RIPK40.82763471
51LIMK10.81905422
52CDK80.80595015
53ATR0.78328619
54DAPK10.76267623
55TAF10.75302973
56RPS6KB20.73368994
57MAP3K140.71970838
58TRIM280.71831783
59PAK10.70418971
60MARK30.69790048
61CHEK10.69499774
62BCKDK0.69039459
63MAP2K30.68960974
64BRAF0.66833253
65ARAF0.65285808
66TBK10.65056036
67MELK0.64134587
68PIM20.59192127
69ALK0.58345183
70MET0.57160044
71RAF10.54728884
72PRKCI0.54659331
73MAPKAPK20.53236156
74ERBB40.52086520
75PTK20.50746580
76CDK40.49499581
77BMPR20.46806417
78LRRK20.46674570
79CDK120.46052521
80ILK0.44876887
81DAPK30.44546804
82KDR0.43022165
83DMPK0.40868942
84ICK0.38800610
85NUAK10.38216488
86CDK90.36745044
87EPHB10.35437116
88TYK20.34145676
89AKT20.33586452
90TRIB30.33559410
91CDK10.33461713
92CSNK2A10.31379115
93MAP4K10.29119461
94ATM0.28757751
95CDK60.28728547
96SIK10.28379349
97CSNK2A20.28160965
98MOS0.27171635
99NEK90.26426878
100BMX0.25151431

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.57236838
2Proteasome_Homo sapiens_hsa030504.56944396
3Mismatch repair_Homo sapiens_hsa034303.61040739
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.59463840
5Non-homologous end-joining_Homo sapiens_hsa034502.56441216
6Base excision repair_Homo sapiens_hsa034102.51398804
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43896443
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41659006
9Cell cycle_Homo sapiens_hsa041102.26285809
10Homologous recombination_Homo sapiens_hsa034402.18464640
11One carbon pool by folate_Homo sapiens_hsa006702.10577099
12Nucleotide excision repair_Homo sapiens_hsa034202.08653418
13Pyrimidine metabolism_Homo sapiens_hsa002401.84558141
14Spliceosome_Homo sapiens_hsa030401.83039087
15Pentose phosphate pathway_Homo sapiens_hsa000301.71661385
16RNA transport_Homo sapiens_hsa030131.67658380
17Biosynthesis of amino acids_Homo sapiens_hsa012301.66657567
18Systemic lupus erythematosus_Homo sapiens_hsa053221.60812298
19Fanconi anemia pathway_Homo sapiens_hsa034601.60449894
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58699654
21Carbon metabolism_Homo sapiens_hsa012001.49465703
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.37322679
23Viral carcinogenesis_Homo sapiens_hsa052031.25341848
24Epstein-Barr virus infection_Homo sapiens_hsa051691.22783469
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20544184
26p53 signaling pathway_Homo sapiens_hsa041151.20002095
27N-Glycan biosynthesis_Homo sapiens_hsa005101.19919131
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15468742
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12720322
30Fructose and mannose metabolism_Homo sapiens_hsa000511.11759865
31Pyruvate metabolism_Homo sapiens_hsa006201.09344409
32Shigellosis_Homo sapiens_hsa051311.08989111
33RNA polymerase_Homo sapiens_hsa030201.08909085
34Glutathione metabolism_Homo sapiens_hsa004801.08894097
35Folate biosynthesis_Homo sapiens_hsa007901.07851950
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03157985
37Fatty acid elongation_Homo sapiens_hsa000621.02729417
38Herpes simplex infection_Homo sapiens_hsa051681.02206750
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00388633
40Galactose metabolism_Homo sapiens_hsa000520.98134104
41Protein export_Homo sapiens_hsa030600.95224573
42Ribosome_Homo sapiens_hsa030100.94535759
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92834537
44Apoptosis_Homo sapiens_hsa042100.92645045
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89296146
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.88104945
47Viral myocarditis_Homo sapiens_hsa054160.86576297
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.85054343
49Influenza A_Homo sapiens_hsa051640.83411483
50Antigen processing and presentation_Homo sapiens_hsa046120.80992005
51Measles_Homo sapiens_hsa051620.80291804
52Primary immunodeficiency_Homo sapiens_hsa053400.79581241
53Thyroid cancer_Homo sapiens_hsa052160.77733166
54Alcoholism_Homo sapiens_hsa050340.76028089
55Sulfur relay system_Homo sapiens_hsa041220.75901299
56Bladder cancer_Homo sapiens_hsa052190.75033162
57Hepatitis B_Homo sapiens_hsa051610.74228557
58Oocyte meiosis_Homo sapiens_hsa041140.72551094
59Purine metabolism_Homo sapiens_hsa002300.72160362
60Allograft rejection_Homo sapiens_hsa053300.71193117
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70709320
62HTLV-I infection_Homo sapiens_hsa051660.70146734
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.69002746
64mRNA surveillance pathway_Homo sapiens_hsa030150.68849096
65RNA degradation_Homo sapiens_hsa030180.67714639
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67176839
67Parkinsons disease_Homo sapiens_hsa050120.66097745
68Pancreatic cancer_Homo sapiens_hsa052120.63336019
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.62888545
70Legionellosis_Homo sapiens_hsa051340.62857671
71Vitamin B6 metabolism_Homo sapiens_hsa007500.61490393
72Autoimmune thyroid disease_Homo sapiens_hsa053200.61274040
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58587590
74Other glycan degradation_Homo sapiens_hsa005110.57886516
75Chronic myeloid leukemia_Homo sapiens_hsa052200.52858170
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.51889520
77Leishmaniasis_Homo sapiens_hsa051400.51843925
78Small cell lung cancer_Homo sapiens_hsa052220.51791073
79Sulfur metabolism_Homo sapiens_hsa009200.50640840
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.49689218
81Oxidative phosphorylation_Homo sapiens_hsa001900.48926087
82Huntingtons disease_Homo sapiens_hsa050160.46756386
83Hepatitis C_Homo sapiens_hsa051600.45861597
84B cell receptor signaling pathway_Homo sapiens_hsa046620.44799658
85Basal transcription factors_Homo sapiens_hsa030220.44116107
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43651482
87Non-small cell lung cancer_Homo sapiens_hsa052230.43427479
88Graft-versus-host disease_Homo sapiens_hsa053320.41979074
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41724859
90Asthma_Homo sapiens_hsa053100.41391177
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41144656
92Acute myeloid leukemia_Homo sapiens_hsa052210.41064621
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37735145
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36401479
95Vibrio cholerae infection_Homo sapiens_hsa051100.33367831
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33167263
97Salmonella infection_Homo sapiens_hsa051320.33021206
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31511250
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29431605
100Prostate cancer_Homo sapiens_hsa052150.29250107

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