APLNR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)9.64735508
2endothelium development (GO:0003158)8.11878232
3lymphangiogenesis (GO:0001946)7.87825470
4vascular endothelial growth factor signaling pathway (GO:0038084)7.61248891
5positive regulation of vasculogenesis (GO:2001214)6.49976490
6cellular response to vascular endothelial growth factor stimulus (GO:0035924)6.25781992
7retina vasculature morphogenesis in camera-type eye (GO:0061299)6.08488722
8hyperosmotic salinity response (GO:0042538)5.73060702
9one-carbon compound transport (GO:0019755)5.66736280
10blood vessel maturation (GO:0001955)5.57231238
11regulation of vasculogenesis (GO:2001212)5.41969490
12basement membrane organization (GO:0071711)5.32063679
13central nervous system myelination (GO:0022010)5.25981906
14axon ensheathment in central nervous system (GO:0032291)5.25981906
15endothelial cell differentiation (GO:0045446)5.20404977
16heart trabecula formation (GO:0060347)5.14414013
17endothelial tube morphogenesis (GO:0061154)5.13628037
18morphogenesis of an endothelium (GO:0003159)5.13628037
19vascular endothelial growth factor receptor signaling pathway (GO:0048010)5.08505866
20vasculogenesis (GO:0001570)4.84325478
21cellular potassium ion homeostasis (GO:0030007)4.72203745
22negative regulation of nitric-oxide synthase activity (GO:0051001)4.58429942
23patterning of blood vessels (GO:0001569)4.55806866
24renal absorption (GO:0070293)4.55508109
25negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.53369814
26cell migration involved in sprouting angiogenesis (GO:0002042)4.53003547
27astrocyte differentiation (GO:0048708)4.48487797
28blood vessel endothelial cell migration (GO:0043534)4.45937271
29embryonic heart tube development (GO:0035050)4.41804344
30regulation of endothelial cell differentiation (GO:0045601)4.37625022
31sodium ion export (GO:0071436)4.36329793
32cardiac myofibril assembly (GO:0055003)4.31242027
33glomerular filtration (GO:0003094)4.27993467
34sprouting angiogenesis (GO:0002040)4.27327837
35plasma membrane repair (GO:0001778)4.17168071
36potassium ion import (GO:0010107)4.08550853
37cell migration involved in heart development (GO:0060973)4.04136734
38cellular response to nitric oxide (GO:0071732)3.96675090
39substrate-dependent cell migration (GO:0006929)3.95106655
40endothelial cell morphogenesis (GO:0001886)3.95059030
41surfactant homeostasis (GO:0043129)3.94763767
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.93795028
43astrocyte development (GO:0014002)3.93712596
44potassium ion homeostasis (GO:0055075)3.90930205
45renal filtration (GO:0097205)3.90655931
46ventricular trabecula myocardium morphogenesis (GO:0003222)3.85521714
47negative regulation of cell fate specification (GO:0009996)3.80497612
48L-amino acid import (GO:0043092)3.76396492
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.72979964
50sarcomere organization (GO:0045214)3.65358683
51heart trabecula morphogenesis (GO:0061384)3.65256158
52regulation of cardioblast differentiation (GO:0051890)3.65101736
53bundle of His cell to Purkinje myocyte communication (GO:0086069)3.64161634
54cGMP-mediated signaling (GO:0019934)3.63141941
55venous blood vessel morphogenesis (GO:0048845)3.59835688
56trabecula formation (GO:0060343)3.58939122
57cell communication by electrical coupling (GO:0010644)3.57801411
58cardiac muscle cell proliferation (GO:0060038)3.56800704
59myofibril assembly (GO:0030239)3.55726886
60cellular sodium ion homeostasis (GO:0006883)3.52121936
61ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.49930234
62endothelial cell migration (GO:0043542)3.49513154
63negative regulation of vascular permeability (GO:0043116)3.49053249
64trabecula morphogenesis (GO:0061383)3.48212254
65axon extension involved in axon guidance (GO:0048846)3.44578140
66neuron projection extension involved in neuron projection guidance (GO:1902284)3.44578140
67peptidyl-tyrosine autophosphorylation (GO:0038083)3.40252017
68Notch signaling involved in heart development (GO:0061314)3.36589930
69neuronal ion channel clustering (GO:0045161)3.35867489
70regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.30510821
71positive regulation of endothelial cell differentiation (GO:0045603)3.30117466
72activation of protein kinase A activity (GO:0034199)3.29743329
73dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.29560844
74amino acid import (GO:0043090)3.29307626
75regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.25294667
76angiogenesis involved in wound healing (GO:0060055)3.20344056
77cardiac muscle tissue morphogenesis (GO:0055008)3.19467322
78coronary vasculature morphogenesis (GO:0060977)3.19205260
79negative regulation of Rho protein signal transduction (GO:0035024)3.16612290
80regulation of tight junction assembly (GO:2000810)3.13668110
81cAMP biosynthetic process (GO:0006171)3.13592151
82regulation of vascular permeability (GO:0043114)3.12501712
83hippo signaling (GO:0035329)3.11787438
84blood vessel morphogenesis (GO:0048514)3.11472153
85heart morphogenesis (GO:0003007)3.09096463
86chemical homeostasis within a tissue (GO:0048875)3.08908986
87positive regulation of protein kinase C signaling (GO:0090037)3.08349074
88negative regulation of endothelial cell proliferation (GO:0001937)3.06966586
89cellular response to reactive nitrogen species (GO:1902170)3.06065568
90positive regulation of endothelial cell migration (GO:0010595)3.04236509
91endothelial cell proliferation (GO:0001935)3.03833735
92establishment of endothelial barrier (GO:0061028)3.02682732
93cell volume homeostasis (GO:0006884)3.02009685
94negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01480558
95response to mercury ion (GO:0046689)3.01197021
96artery development (GO:0060840)3.00687170
97regulation of skeletal muscle cell differentiation (GO:2001014)3.00545765
98water transport (GO:0006833)2.96885639
99negative regulation of blood vessel endothelial cell migration (GO:0043537)2.96633447
100endocrine hormone secretion (GO:0060986)2.95675104
101regulation of actin filament-based movement (GO:1903115)2.94576560
102ovulation from ovarian follicle (GO:0001542)2.93115570
103neurotransmitter uptake (GO:0001504)2.90598923
104cell migration involved in gastrulation (GO:0042074)2.88914948
105muscle tissue morphogenesis (GO:0060415)2.88821050
106negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.88381547
107cellular hyperosmotic response (GO:0071474)2.88099098
108regulation of endothelial cell migration (GO:0010594)2.88038104
109adherens junction assembly (GO:0034333)2.87897168
110striated muscle cell proliferation (GO:0014855)2.87604054
111cell surface receptor signaling pathway involved in heart development (GO:0061311)2.86619146
112cardiac muscle cell development (GO:0055013)2.86265689
113positive regulation of cell junction assembly (GO:1901890)2.85521063
114positive regulation of focal adhesion assembly (GO:0051894)2.85521063
115branching involved in salivary gland morphogenesis (GO:0060445)2.85451961
116positive regulation of endothelial cell proliferation (GO:0001938)2.85235251
117positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.83838702
118negative regulation of endothelial cell apoptotic process (GO:2000352)2.83616656
119peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.83575606
120regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.83481888
121exocrine pancreas development (GO:0031017)2.83052572
122response to nitric oxide (GO:0071731)2.82781432
123positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.82738790
124regulation of sarcomere organization (GO:0060297)2.82399548
125mRNA transcription from RNA polymerase II promoter (GO:0042789)2.81087096
126postsynaptic membrane organization (GO:0001941)2.80167203
127actin-myosin filament sliding (GO:0033275)2.79098910
128muscle filament sliding (GO:0030049)2.79098910
129cardiac cell development (GO:0055006)2.78904782
130cyclic purine nucleotide metabolic process (GO:0052652)2.78311419
131regulation of endothelial cell proliferation (GO:0001936)2.78053796
132embryonic foregut morphogenesis (GO:0048617)2.77820925
133polyol transport (GO:0015791)2.77778699
134semaphorin-plexin signaling pathway (GO:0071526)2.77109003
135neuron projection regeneration (GO:0031102)2.75859825
136regulation of the force of heart contraction (GO:0002026)2.75843437
137axon ensheathment (GO:0008366)2.75475072
138ensheathment of neurons (GO:0007272)2.75475072
139negative regulation of endothelial cell migration (GO:0010596)2.74604264
140angiogenesis (GO:0001525)2.72355043
141response to dietary excess (GO:0002021)2.71316258
142myelination (GO:0042552)2.71032955
143positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70895024
144regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.70715791
145vocalization behavior (GO:0071625)2.69136984
146myelin maintenance (GO:0043217)2.69077107
147fluid transport (GO:0042044)2.68596309
148regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.64993670
149response to methylmercury (GO:0051597)2.63058739
150regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.62915504
151myelination in peripheral nervous system (GO:0022011)2.60842512
152peripheral nervous system axon ensheathment (GO:0032292)2.60842512
153cyclic nucleotide biosynthetic process (GO:0009190)2.60122778
154metanephric nephron epithelium development (GO:0072243)2.59703990
155regulation of p38MAPK cascade (GO:1900744)2.58228541
156presynaptic membrane organization (GO:0097090)2.57532329
157metanephric nephron tubule development (GO:0072234)2.55704485
158metanephric tubule development (GO:0072170)2.55704485
159regulation of apoptotic cell clearance (GO:2000425)2.55502042
160embryonic retina morphogenesis in camera-type eye (GO:0060059)2.53952206
161regulation of synapse structural plasticity (GO:0051823)2.53506372
162regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53462004
163synaptic vesicle docking involved in exocytosis (GO:0016081)2.52436200
164neurotransmitter-gated ion channel clustering (GO:0072578)2.51983482
165cell communication involved in cardiac conduction (GO:0086065)2.51916786
166regulation of synapse maturation (GO:0090128)2.50840888
167positive regulation of macrophage cytokine production (GO:0060907)2.49909912
168dermatan sulfate biosynthetic process (GO:0030208)2.48935213
169gas transport (GO:0015669)2.47580976
170regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.47116295
171presynaptic membrane assembly (GO:0097105)2.45711065
172negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.42042217
173regulation of cardiac muscle cell contraction (GO:0086004)2.40499545
174neurotransmitter catabolic process (GO:0042135)2.37367546
175substantia nigra development (GO:0021762)2.37330372
176photoreceptor cell differentiation (GO:0046530)2.36541053
177eye photoreceptor cell differentiation (GO:0001754)2.36541053
178positive regulation of synapse maturation (GO:0090129)2.35997684
179positive regulation of digestive system process (GO:0060456)2.35642793
180cerebellar granule cell differentiation (GO:0021707)2.35295352
181metanephric epithelium development (GO:0072207)2.33724693
182dermatan sulfate metabolic process (GO:0030205)2.33289566
183cardiac epithelial to mesenchymal transition (GO:0060317)2.32542310
184regulation of neurotransmitter uptake (GO:0051580)2.31450541
185neuronal action potential propagation (GO:0019227)2.31359683
186regulation of skeletal muscle contraction (GO:0014819)2.30758384
187regulation of female receptivity (GO:0045924)2.29787153
188locomotory exploration behavior (GO:0035641)2.29036801
189positive regulation of p38MAPK cascade (GO:1900745)2.28933490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.39571928
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.46078866
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.40921321
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.40446169
5GATA2_21666600_ChIP-Seq_HMVEC_Human3.39836968
6CLOCK_20551151_ChIP-Seq_293T_Human3.33336298
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.26662295
8EP300_21415370_ChIP-Seq_HL-1_Mouse3.23632086
9EZH2_22144423_ChIP-Seq_EOC_Human3.09257706
10ELK3_25401928_ChIP-Seq_HUVEC_Human3.02206136
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.95079975
12EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.81234311
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68726466
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.66237621
15TBX20_22080862_ChIP-Seq_HEART_Mouse2.53316279
16TBX20_22328084_ChIP-Seq_HEART_Mouse2.53316279
17HIF1A_21447827_ChIP-Seq_MCF-7_Human2.46551718
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.44121540
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.31158246
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30580743
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.28955503
22ZNF263_19887448_ChIP-Seq_K562_Human2.21961194
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17342446
24ESR1_20079471_ChIP-ChIP_T-47D_Human2.15154782
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.13731039
26GBX2_23144817_ChIP-Seq_PC3_Human2.12202301
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.07612978
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06540929
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03277218
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.01967682
31KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01892655
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.96710693
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95963907
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95880923
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95186367
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94952860
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94952860
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94952860
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.91228282
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.86084131
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84026133
42DROSHA_22980978_ChIP-Seq_HELA_Human1.78861320
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73511484
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.71984959
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.70975599
46SMAD3_21741376_ChIP-Seq_HESCs_Human1.70692286
47MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.70431544
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70174175
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68359344
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59446915
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58754213
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58595167
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56955913
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53765884
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51519946
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49796544
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48250980
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46184218
59ISL1_27105846_Chip-Seq_CPCs_Mouse1.45211571
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44116522
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44110967
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.43774346
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.43672299
64SMAD4_21741376_ChIP-Seq_HESCs_Human1.42708213
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42306896
66WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42002715
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.41737796
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39653068
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38024872
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36683097
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.35944465
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34447137
73BRD4_25478319_ChIP-Seq_HGPS_Human1.34377996
74* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31889647
75* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30923588
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.30687635
77* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.30109714
78CJUN_26792858_Chip-Seq_BT549_Human1.30049840
79* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.30032792
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29958289
81GATA1_19941826_ChIP-Seq_K562_Human1.29745865
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.29744052
83FOXM1_23109430_ChIP-Seq_U2OS_Human1.26092789
84SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25787083
85KDM2B_26808549_Chip-Seq_DND41_Human1.25760946
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24735066
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24473901
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23453501
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23453501
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21796218
91AR_21572438_ChIP-Seq_LNCaP_Human1.21447242
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21359468
93KDM2B_26808549_Chip-Seq_K562_Human1.19525270
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19351066
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18109436
96RACK7_27058665_Chip-Seq_MCF-7_Human1.17814686
97CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16868570
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16845613
99ESR1_21235772_ChIP-Seq_MCF-7_Human1.15858844
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15805170
101CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15313560
102GATA1_22025678_ChIP-Seq_K562_Human1.15149590
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15128849
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15020747
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14641499
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14641499
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.13281231
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12777584
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.12654059
110TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11866972
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.11627276
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11525020
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10477815
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09796219
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09602386
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09152378
117SMAD4_21799915_ChIP-Seq_A2780_Human1.08511602
118FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07372504
119FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07290348
120* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07111436
121REST_21632747_ChIP-Seq_MESCs_Mouse1.06945344
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06024777
123ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05554687
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03319158
125KDM2B_26808549_Chip-Seq_JURKAT_Human1.03228382
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03205331
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02050140
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01944424
129SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01500637
130PIAS1_25552417_ChIP-Seq_VCAP_Human1.00443648
131SMAD3_21741376_ChIP-Seq_ESCs_Human1.00330987
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00105228
133SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99962619
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99362665
135UBF1/2_26484160_Chip-Seq_HMECs_Human0.98159268
136SOX2_21211035_ChIP-Seq_LN229_Gbm0.98076682
137PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98009952
138TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97639719
139SOX2_20726797_ChIP-Seq_SW620_Human0.96857447
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96640982
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.96632400
142TP53_20018659_ChIP-ChIP_R1E_Mouse0.96533584
143TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96079209
144LXR_22292898_ChIP-Seq_THP-1_Human0.95773419
145CBX2_27304074_Chip-Seq_ESCs_Mouse0.95444560
146GATA4_21415370_ChIP-Seq_HL-1_Mouse0.95378766
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95001833
148NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94762643
149ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93319675
150POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93193852
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92613891
152GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92298344
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91769064
154TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91615089
155NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86046407
156TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85655868
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85507153
158AR_19668381_ChIP-Seq_PC3_Human0.83929793
159NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83097286
160NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83097286
161OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82024172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system8.23397453
2MP0001879_abnormal_lymphatic_vessel6.11542909
3MP0004272_abnormal_basement_membrane4.62286414
4MP0003690_abnormal_glial_cell4.26394876
5MP0005167_abnormal_blood-brain_barrier3.34556260
6MP0003828_pulmonary_edema3.28744473
7MP0003705_abnormal_hypodermis_morpholog3.26266323
8MP0004084_abnormal_cardiac_muscle3.18658126
9MP0006054_spinal_hemorrhage3.15875099
10MP0004270_analgesia2.89963918
11MP0005423_abnormal_somatic_nervous2.67592195
12MP0003122_maternal_imprinting2.50040585
13MP0004859_abnormal_synaptic_plasticity2.46033674
14MP0000920_abnormal_myelination2.42598305
15MP0003950_abnormal_plasma_membrane2.37373096
16* MP0004215_abnormal_myocardial_fiber2.36972811
17MP0006138_congestive_heart_failure2.35500155
18MP0000751_myopathy2.19352412
19MP0000013_abnormal_adipose_tissue2.12173433
20MP0002837_dystrophic_cardiac_calcinosis1.96874752
21MP0004885_abnormal_endolymph1.95736969
22MP0003890_abnormal_embryonic-extraembry1.94848601
23MP0003279_aneurysm1.94296031
24MP0000767_abnormal_smooth_muscle1.86839344
25MP0001486_abnormal_startle_reflex1.84866353
26MP0003633_abnormal_nervous_system1.84039024
27MP0009780_abnormal_chondrocyte_physiolo1.82963201
28MP0005330_cardiomyopathy1.81145204
29MP0010630_abnormal_cardiac_muscle1.81110652
30MP0004036_abnormal_muscle_relaxation1.81076174
31MP0003329_amyloid_beta_deposits1.80018371
32MP0005385_cardiovascular_system_phenoty1.79742859
33MP0001544_abnormal_cardiovascular_syste1.79742859
34MP0003635_abnormal_synaptic_transmissio1.76230835
35MP0005623_abnormal_meninges_morphology1.71889086
36MP0000747_muscle_weakness1.71626290
37MP0003191_abnormal_cellular_cholesterol1.69296537
38MP0002735_abnormal_chemical_nociception1.68679763
39MP0003724_increased_susceptibility_to1.67665800
40MP0002127_abnormal_cardiovascular_syste1.63926546
41MP0003567_abnormal_fetal_cardiomyocyte1.62664094
42MP0003634_abnormal_glial_cell1.56750056
43MP0002064_seizures1.53493940
44MP0008569_lethality_at_weaning1.52167701
45MP0004087_abnormal_muscle_fiber1.50197989
46MP0000750_abnormal_muscle_regeneration1.50176175
47MP0002734_abnormal_mechanical_nocicepti1.49757573
48MP0003631_nervous_system_phenotype1.49494413
49MP0002272_abnormal_nervous_system1.48870949
50MP0008438_abnormal_cutaneous_collagen1.47321209
51* MP0002925_abnormal_cardiovascular_devel1.44160619
52MP0008775_abnormal_heart_ventricle1.43744753
53MP0003879_abnormal_hair_cell1.43075169
54* MP0002972_abnormal_cardiac_muscle1.42899843
55* MP0002332_abnormal_exercise_endurance1.37084166
56MP0003385_abnormal_body_wall1.35411076
57MP0005165_increased_susceptibility_to1.34777850
58MP0004085_abnormal_heartbeat1.33655882
59MP0002128_abnormal_blood_circulation1.32352486
60MP0004145_abnormal_muscle_electrophysio1.31851790
61MP0003566_abnormal_cell_adhesion1.30080737
62MP0003632_abnormal_nervous_system1.29176654
63MP0000749_muscle_degeneration1.27306660
64MP0001177_atelectasis1.26074745
65MP0001614_abnormal_blood_vessel1.24851048
66* MP0000266_abnormal_heart_morphology1.24602713
67MP0005409_darkened_coat_color1.23303397
68MP0003880_abnormal_central_pattern1.23224856
69MP0002063_abnormal_learning/memory/cond1.23128609
70MP0003075_altered_response_to1.22864402
71MP0001502_abnormal_circadian_rhythm1.22098090
72MP0004147_increased_porphyrin_level1.21733593
73MP0001984_abnormal_olfaction1.19975035
74MP0000778_abnormal_nervous_system1.19279465
75* MP0005620_abnormal_muscle_contractility1.19137903
76MP0001485_abnormal_pinna_reflex1.18453414
77MP0004484_altered_response_of1.17787127
78MP0009745_abnormal_behavioral_response1.17528400
79MP0001915_intracranial_hemorrhage1.17041020
80MP0001970_abnormal_pain_threshold1.15783033
81MP0002249_abnormal_larynx_morphology1.14682634
82MP0000462_abnormal_digestive_system1.14607276
83MP0004185_abnormal_adipocyte_glucose1.13998628
84MP0006276_abnormal_autonomic_nervous1.13056230
85MP0005360_urolithiasis1.12847441
86MP0010030_abnormal_orbit_morphology1.12120020
87MP0004130_abnormal_muscle_cell1.12097161
88MP0005595_abnormal_vascular_smooth1.09328667
89MP0000003_abnormal_adipose_tissue1.07974517
90MP0002106_abnormal_muscle_physiology1.07345316
91MP0002971_abnormal_brown_adipose1.05277596
92MP0000249_abnormal_blood_vessel1.03628445
93MP0001299_abnormal_eye_distance/1.03129570
94MP0002088_abnormal_embryonic_growth/wei1.03126760
95MP0003121_genomic_imprinting1.02671295
96MP0003984_embryonic_growth_retardation1.02650065
97MP0002733_abnormal_thermal_nociception1.01846169
98MP0003119_abnormal_digestive_system1.01569596
99MP0000343_altered_response_to1.01140128
100MP0003300_gastrointestinal_ulcer1.00844455
101MP0005503_abnormal_tendon_morphology0.99912133
102MP0005670_abnormal_white_adipose0.99529433
103MP0001784_abnormal_fluid_regulation0.96267818
104MP0002572_abnormal_emotion/affect_behav0.96219580
105MP0009278_abnormal_bone_marrow0.95350948
106MP0002086_abnormal_extraembryonic_tissu0.93599845
107MP0001501_abnormal_sleep_pattern0.92801416
108MP0001905_abnormal_dopamine_level0.92329002
109MP0002108_abnormal_muscle_morphology0.90501931
110MP0000733_abnormal_muscle_development0.90365420
111MP0001672_abnormal_embryogenesis/_devel0.88101522
112MP0005380_embryogenesis_phenotype0.88101522
113MP0005171_absent_coat_pigmentation0.87563074
114MP0000762_abnormal_tongue_morphology0.86854089
115MP0003137_abnormal_impulse_conducting0.86626788
116MP0000537_abnormal_urethra_morphology0.86079068
117MP0003935_abnormal_craniofacial_develop0.85372124
118MP0005369_muscle_phenotype0.84120193
119MP0003123_paternal_imprinting0.82895872
120MP0000759_abnormal_skeletal_muscle0.82759001
121MP0002066_abnormal_motor_capabilities/c0.81621288
122MP0004510_myositis0.81582064
123MP0003091_abnormal_cell_migration0.80441067
124MP0004883_abnormal_blood_vessel0.79840794
125MP0001963_abnormal_hearing_physiology0.79679854
126MP0002269_muscular_atrophy0.79288712
127MP0002295_abnormal_pulmonary_circulatio0.78250153
128MP0005275_abnormal_skin_tensile0.77353085
129MP0003195_calcinosis0.76562230
130MP0000428_abnormal_craniofacial_morphol0.76445635
131MP0005187_abnormal_penis_morphology0.75072877
132MP0003221_abnormal_cardiomyocyte_apopto0.74346988
133MP0004858_abnormal_nervous_system0.74121458
134MP0000955_abnormal_spinal_cord0.74078251
135MP0005646_abnormal_pituitary_gland0.73596508
136MP0005375_adipose_tissue_phenotype0.72483483
137MP0003646_muscle_fatigue0.71778794
138MP0002932_abnormal_joint_morphology0.70164533
139MP0010352_gastrointestinal_tract_polyps0.69586536
140MP0003045_fibrosis0.68503564
141MP0001958_emphysema0.67832899
142MP0003943_abnormal_hepatobiliary_system0.67689843
143MP0000465_gastrointestinal_hemorrhage0.65769154
144MP0008004_abnormal_stomach_pH0.65330564
145MP0004808_abnormal_hematopoietic_stem0.62697213
146MP0001697_abnormal_embryo_size0.60287085
147MP0003303_peritoneal_inflammation0.57044731
148MP0005666_abnormal_adipose_tissue0.56441565
149MP0002133_abnormal_respiratory_system0.55643355
150MP0005388_respiratory_system_phenotype0.55643355
151MP0001851_eye_inflammation0.54284594
152MP0002896_abnormal_bone_mineralization0.53695697

Predicted human phenotypes

RankGene SetZ-score
1Nonimmune hydrops fetalis (HP:0001790)5.18963191
2Ventricular tachycardia (HP:0004756)4.88248914
3Sudden death (HP:0001699)4.71673984
4Action tremor (HP:0002345)4.61939706
5Muscle fiber splitting (HP:0003555)4.46965519
6Protrusio acetabuli (HP:0003179)4.40718016
7Lymphangioma (HP:0100764)4.35007335
8Broad metatarsal (HP:0001783)4.34643133
9Hematochezia (HP:0002573)4.12188947
10Atrial fibrillation (HP:0005110)3.93817962
11Peripheral hypomyelination (HP:0007182)3.90349962
12Cerebral aneurysm (HP:0004944)3.89773220
13Polycythemia (HP:0001901)3.89435668
14Increased connective tissue (HP:0009025)3.86715377
15Supraventricular arrhythmia (HP:0005115)3.84472455
16Primary atrial arrhythmia (HP:0001692)3.72041128
17Spontaneous hematomas (HP:0007420)3.69854506
18Skull defect (HP:0001362)3.66819948
19Lipoatrophy (HP:0100578)3.66521624
20Supraventricular tachycardia (HP:0004755)3.58708140
21Asymmetry of the thorax (HP:0001555)3.49411476
22Systemic lupus erythematosus (HP:0002725)3.42740327
23Complement deficiency (HP:0004431)3.38604021
24Hyporeflexia of lower limbs (HP:0002600)3.36497439
25Neoplasm of the heart (HP:0100544)3.33245770
26Bell-shaped thorax (HP:0001591)3.32130273
27Aplasia involving bones of the extremities (HP:0009825)3.24454816
28Aplasia involving bones of the upper limbs (HP:0009823)3.24454816
29Aplasia of the phalanges of the hand (HP:0009802)3.24454816
30Esophageal varix (HP:0002040)3.23618582
31Capillary hemangiomas (HP:0005306)3.23328753
32Ulnar claw (HP:0001178)3.19927303
33Short 4th metacarpal (HP:0010044)3.18458228
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.18458228
35Right ventricular cardiomyopathy (HP:0011663)3.16434362
36Neurofibrillary tangles (HP:0002185)3.11771067
37Myotonia (HP:0002486)3.07779993
38Obstructive sleep apnea (HP:0002870)3.07478729
39Wrist flexion contracture (HP:0001239)3.05113539
40Distal arthrogryposis (HP:0005684)3.00692261
41Difficulty running (HP:0009046)2.93652331
42Termporal pattern (HP:0011008)2.92238987
43Insidious onset (HP:0003587)2.92238987
44Glomerulonephritis (HP:0000099)2.88031574
45Exercise-induced muscle cramps (HP:0003710)2.80875552
46Congenital malformation of the right heart (HP:0011723)2.80593359
47Double outlet right ventricle (HP:0001719)2.80593359
48Spinal rigidity (HP:0003306)2.78709382
49Reduced subcutaneous adipose tissue (HP:0003758)2.76364373
50Increased variability in muscle fiber diameter (HP:0003557)2.75690227
51Abnormality of the 4th metacarpal (HP:0010012)2.74038725
52Absent eyebrow (HP:0002223)2.72100998
53Cerebral hemorrhage (HP:0001342)2.70694322
54Calf muscle hypertrophy (HP:0008981)2.70563667
55Neonatal death (HP:0003811)2.69735128
56Hammertoe (HP:0001765)2.68458442
57Adactyly (HP:0009776)2.66534707
58Round ear (HP:0100830)2.65773577
59Overgrowth (HP:0001548)2.63921737
60Subaortic stenosis (HP:0001682)2.63296879
61Abnormality of the left ventricular outflow tract (HP:0011103)2.63296879
62Large hands (HP:0001176)2.60264998
63Absent eyelashes (HP:0000561)2.58625521
64Abnormality of the calf musculature (HP:0001430)2.57268392
65Abnormality of skeletal muscle fiber size (HP:0012084)2.57207296
66Foot dorsiflexor weakness (HP:0009027)2.57193506
67High pitched voice (HP:0001620)2.57003062
68Difficulty climbing stairs (HP:0003551)2.56502160
69EMG: myopathic abnormalities (HP:0003458)2.56429955
70Megalencephaly (HP:0001355)2.53844232
71Dilated cardiomyopathy (HP:0001644)2.53449449
72Abnormality of complement system (HP:0005339)2.52817248
73Increased CSF protein (HP:0002922)2.52274974
74Ankle clonus (HP:0011448)2.52164562
75Short hallux (HP:0010109)2.51140722
76Hemiplegia (HP:0002301)2.51111147
77Segmental peripheral demyelination/remyelination (HP:0003481)2.51011887
78Abnormality of the foot musculature (HP:0001436)2.49971173
79Abnormality of binocular vision (HP:0011514)2.47967842
80Diplopia (HP:0000651)2.47967842
81Lymphedema (HP:0001004)2.46044725
82Shallow orbits (HP:0000586)2.45829002
83Venous insufficiency (HP:0005293)2.44434396
84Hypoplastic ischia (HP:0003175)2.43427292
85Atrioventricular block (HP:0001678)2.43196931
86Aneurysm (HP:0002617)2.43009476
87Hypoplastic left heart (HP:0004383)2.42197296
88Bundle branch block (HP:0011710)2.41650129
89Growth hormone excess (HP:0000845)2.41153631
90Syncope (HP:0001279)2.39980775
91Exercise-induced myalgia (HP:0003738)2.39615172
92Visceral angiomatosis (HP:0100761)2.39006800
93Muscle fiber inclusion bodies (HP:0100299)2.38126105
94Muscle hypertrophy of the lower extremities (HP:0008968)2.37434619
95Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.35238417
96Mucosal telangiectasiae (HP:0100579)2.33872792
97Cavernous hemangioma (HP:0001048)2.32861450
98Prolonged QT interval (HP:0001657)2.31921499
99Camptodactyly of toe (HP:0001836)2.31665152
100Nemaline bodies (HP:0003798)2.29560168
101Porencephaly (HP:0002132)2.29499558
102Aplasia/Hypoplasia of the hallux (HP:0008362)2.29402660
103Venous abnormality (HP:0002624)2.27829013
104Centrally nucleated skeletal muscle fibers (HP:0003687)2.26148603
105Flexion contracture of toe (HP:0005830)2.24698393
106Joint contractures involving the joints of the feet (HP:0100492)2.24698393
107Abnormality of the ischium (HP:0003174)2.23128489
108Conjunctival telangiectasia (HP:0000524)2.23018420
109Hemangiomatosis (HP:0007461)2.22911049
110Absent hand (HP:0004050)2.21392710
111Aortic aneurysm (HP:0004942)2.20747704
112Hypoplastic heart (HP:0001961)2.19745123
113Bicuspid aortic valve (HP:0001647)2.19553600
114Turricephaly (HP:0000262)2.19462901
115Areflexia of lower limbs (HP:0002522)2.19327831
116Cerebral inclusion bodies (HP:0100314)2.18383649
117Congenital, generalized hypertrichosis (HP:0004540)2.17187012
118Myoglobinuria (HP:0002913)2.17078825
119Hip contracture (HP:0003273)2.15416215
120Split foot (HP:0001839)2.15226926
121Fetal akinesia sequence (HP:0001989)2.14577247
122Increased circulating renin level (HP:0000848)2.13931723
123Long eyelashes (HP:0000527)2.12751240
124Palpitations (HP:0001962)2.11814743
125Abnormality of the pulmonary veins (HP:0011718)2.11300234
126Prominent supraorbital ridges (HP:0000336)2.10777908
127Alacrima (HP:0000522)2.08795839
128Anomalous pulmonary venous return (HP:0010772)2.07993947
129Abnormality of the parietal bone (HP:0002696)2.02262120
130Aortic dissection (HP:0002647)2.02177606
131Heart block (HP:0012722)2.02019104
132Portal hypertension (HP:0001409)2.00246660
133Steppage gait (HP:0003376)1.99606393
134Limited hip movement (HP:0008800)1.97294986
135Cutis marmorata (HP:0000965)1.97271781
136Abnormality of the nasal mucosa (HP:0000433)1.95171296
137Rectal prolapse (HP:0002035)1.95124510
138Bone cyst (HP:0012062)1.94399438
139Ventricular fibrillation (HP:0001663)1.93230389
140Pulmonary artery stenosis (HP:0004415)1.92739979
141Cutaneous syndactyly (HP:0012725)1.90881703
142Focal motor seizures (HP:0011153)1.90564351
143Abnormality of the periventricular white matter (HP:0002518)1.90432251
144Abnormal auditory evoked potentials (HP:0006958)1.90309002
145Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89470161
146Thickened helices (HP:0000391)1.88437834
147Absent toe (HP:0010760)1.87654970
148Abnormal atrioventricular conduction (HP:0005150)1.87139022
149Renal duplication (HP:0000075)1.85786828
150Hypoplasia of the iris (HP:0007676)1.85582690
151Type 1 muscle fiber predominance (HP:0003803)1.84259987
152Premature rupture of membranes (HP:0001788)1.84104100
153Neck muscle weakness (HP:0000467)1.83628356
154Decreased motor nerve conduction velocity (HP:0003431)1.83141839
155Abnormal eating behavior (HP:0100738)1.82915786
156Intestinal polyp (HP:0005266)1.82834429
157Abnormality of the peritoneum (HP:0002585)1.82196404
158Hemiparesis (HP:0001269)1.81259714
159Neoplasm of the oral cavity (HP:0100649)1.81154700
160Akinesia (HP:0002304)1.80923240
161Axonal loss (HP:0003447)1.80590469
162Skin pits (HP:0100276)1.78245333
163Myokymia (HP:0002411)1.76757654
164Preauricular pit (HP:0004467)1.74214491
165Periauricular skin pits (HP:0100277)1.74214491
166Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.72887460
167Scanning speech (HP:0002168)1.71818295
168Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70410559
169Distal lower limb muscle weakness (HP:0009053)1.67477249

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.99617376
2KDR9.34992602
3NTRK33.59584691
4TGFBR13.12070132
5TGFBR23.07983001
6MARK12.53095586
7NTRK22.12070939
8DDR22.11961184
9UHMK12.03838834
10EPHB22.01752502
11TTN1.89122257
12TYRO31.86799100
13LATS21.83029905
14RIPK11.77173321
15PKN21.76481533
16EPHA41.76352423
17NTRK11.74143678
18PTK2B1.68607170
19DMPK1.59353173
20PTK61.53855310
21CASK1.49092837
22SGK2231.45476439
23SGK4941.45476439
24TRIB31.44749132
25CAMK2B1.42132488
26SGK21.42125349
27PKN11.36797972
28TNIK1.33888089
29CAMK2G1.31905329
30PAK41.31722077
31FES1.27693325
32ERN11.23941055
33MAP2K31.18231727
34FER1.17767302
35SCYL21.15104148
36NEK61.13531819
37PLK41.12072603
38MYLK1.08727665
39PDGFRA1.07576778
40MAPK101.06161585
41PAK61.04933070
42MAPK41.04228354
43EPHB11.00529825
44SGK30.99712231
45OBSCN0.96935972
46TSSK60.96907007
47LMTK20.96477013
48PINK10.95812971
49GRK10.95109030
50DAPK20.93061596
51CAMK2D0.91030661
52SGK10.89358920
53LATS10.89090366
54ERBB20.87490248
55CDK50.87361674
56PTK20.83199458
57MINK10.81181227
58CAMK2A0.81163282
59MAP3K100.79615472
60PRKD30.77790884
61LRRK20.76539828
62PRKD10.75390828
63MAPK120.75230807
64ALK0.72054269
65NEK90.69462882
66PRKG10.68421966
67STK100.67769934
68PHKG20.67384726
69PHKG10.67384726
70MARK20.64593924
71STK38L0.60983221
72NEK10.60968356
73PDK20.60627332
74MAP2K10.59246830
75MAP3K30.58947821
76PRKG20.58821626
77MAPK130.58649948
78KSR20.57812761
79MAP3K40.57019319
80TNK20.56262103
81MET0.56095898
82ILK0.55490738
83CAMK10.55009933
84PLK20.54839676
85RPS6KA30.53630092
86FGFR30.50820333
87FGFR10.50618544
88MAP3K110.49910685
89ACVR1B0.47910123
90BCKDK0.47631257
91PDK30.46694216
92PDK40.46694216
93BMX0.46542290
94MAP2K40.45754872
95AKT30.40578308
96CAMK40.40135658
97ROCK10.39609565
98FGFR40.39352029
99FGFR20.38589172
100SRC0.37438852
101PDGFRB0.37333709
102PRKACG0.37080227
103MAP3K80.36566022
104BCR0.36256965
105NEK20.36231218
106ERBB40.35397025
107STK30.34904526
108INSRR0.34893320
109IGF1R0.34651316
110PRKCG0.33464782
111MARK30.32572514
112TAOK20.31299514
113DYRK1A0.30913406
114PBK0.30767062
115CSK0.30592070
116ABL20.30400294
117PRKAA20.30109803
118RET0.29533729
119PRKCH0.29359100
120MTOR0.29137874
121SIK10.28893762
122ROCK20.28199550
123CDK80.26962786
124CDK90.26479625
125MAPK70.26418149
126MAP3K10.26303693
127STK240.26018769
128PAK20.25071236
129EGFR0.24262155
130PAK30.23917571
131BMPR1B0.23374729
132CDK60.23326270
133PIK3CA0.23290325
134AKT20.22553351
135INSR0.21517889
136FLT30.21305012
137TEC0.21201750
138EPHA30.21151757
139BUB10.21043567
140STK40.20964211
141MAP3K70.19767606
142SIK20.19722079
143MKNK10.18864542
144GSK3A0.18473238
145JAK20.16090396
146PRKACB0.14238462
147JAK10.13948515
148GRK70.12842116
149MKNK20.12064782
150PRKAA10.11817375
151CAMK1D0.11344314
152NLK0.10884597
153PRKCE0.10452123
154CAMK1G0.10309364

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.74958009
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.19516339
3Dilated cardiomyopathy_Homo sapiens_hsa054143.18734008
4ECM-receptor interaction_Homo sapiens_hsa045122.98299016
5Adherens junction_Homo sapiens_hsa045202.86955516
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.84461295
7Focal adhesion_Homo sapiens_hsa045102.77094817
8Histidine metabolism_Homo sapiens_hsa003402.74103617
9Viral myocarditis_Homo sapiens_hsa054162.61554024
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.47173591
11Leukocyte transendothelial migration_Homo sapiens_hsa046702.14856949
12Circadian entrainment_Homo sapiens_hsa047132.11551287
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06506347
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.05696071
15Rap1 signaling pathway_Homo sapiens_hsa040151.96294104
16GABAergic synapse_Homo sapiens_hsa047271.92909053
17Small cell lung cancer_Homo sapiens_hsa052221.88442019
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88417308
19Cardiac muscle contraction_Homo sapiens_hsa042601.79056801
20Proteoglycans in cancer_Homo sapiens_hsa052051.78463589
21Tight junction_Homo sapiens_hsa045301.78258578
22Insulin secretion_Homo sapiens_hsa049111.77733699
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76074091
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71732460
25Morphine addiction_Homo sapiens_hsa050321.71531084
26Arginine and proline metabolism_Homo sapiens_hsa003301.65521596
27Glutamatergic synapse_Homo sapiens_hsa047241.64596742
28Long-term potentiation_Homo sapiens_hsa047201.63537516
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57129593
30Basal cell carcinoma_Homo sapiens_hsa052171.49826423
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.48975783
32Notch signaling pathway_Homo sapiens_hsa043301.47375787
33Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.47287159
34Salivary secretion_Homo sapiens_hsa049701.45544904
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43839560
36Prion diseases_Homo sapiens_hsa050201.40251590
37Nicotine addiction_Homo sapiens_hsa050331.40191979
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40095774
39Hippo signaling pathway_Homo sapiens_hsa043901.37377667
40Amphetamine addiction_Homo sapiens_hsa050311.33310246
41Propanoate metabolism_Homo sapiens_hsa006401.32133024
42Platelet activation_Homo sapiens_hsa046111.31969329
43Dorso-ventral axis formation_Homo sapiens_hsa043201.31852487
44beta-Alanine metabolism_Homo sapiens_hsa004101.30758386
45Axon guidance_Homo sapiens_hsa043601.30461806
46Insulin resistance_Homo sapiens_hsa049311.29552231
47Phenylalanine metabolism_Homo sapiens_hsa003601.27573514
48Pathways in cancer_Homo sapiens_hsa052001.27138619
49VEGF signaling pathway_Homo sapiens_hsa043701.25093418
50Amoebiasis_Homo sapiens_hsa051461.23658262
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19425264
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19404712
53Malaria_Homo sapiens_hsa051441.18238679
54Thyroid hormone synthesis_Homo sapiens_hsa049181.17558039
55Protein digestion and absorption_Homo sapiens_hsa049741.16230958
56TGF-beta signaling pathway_Homo sapiens_hsa043501.13238262
57HIF-1 signaling pathway_Homo sapiens_hsa040661.12448449
58Toxoplasmosis_Homo sapiens_hsa051451.12283793
59Calcium signaling pathway_Homo sapiens_hsa040201.12082765
60Cocaine addiction_Homo sapiens_hsa050301.11008757
61Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10941767
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10352765
63Renal cell carcinoma_Homo sapiens_hsa052111.08728892
64Dopaminergic synapse_Homo sapiens_hsa047281.07155984
65Pancreatic secretion_Homo sapiens_hsa049721.04575875
66Fatty acid degradation_Homo sapiens_hsa000711.02736112
67HTLV-I infection_Homo sapiens_hsa051661.01761723
68Complement and coagulation cascades_Homo sapiens_hsa046101.01655785
69Ras signaling pathway_Homo sapiens_hsa040141.01565833
70Vascular smooth muscle contraction_Homo sapiens_hsa042701.01147926
71Melanogenesis_Homo sapiens_hsa049160.99967248
72Cholinergic synapse_Homo sapiens_hsa047250.99502727
73Hedgehog signaling pathway_Homo sapiens_hsa043400.99454021
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98274020
75Thyroid cancer_Homo sapiens_hsa052160.97079199
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96821910
77Gap junction_Homo sapiens_hsa045400.96045597
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95361039
79Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92912331
80MicroRNAs in cancer_Homo sapiens_hsa052060.92536141
81Renin secretion_Homo sapiens_hsa049240.88899828
82African trypanosomiasis_Homo sapiens_hsa051430.84974346
83PPAR signaling pathway_Homo sapiens_hsa033200.79927485
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79441301
85Endocytosis_Homo sapiens_hsa041440.76387410
86Synaptic vesicle cycle_Homo sapiens_hsa047210.75777117
87Carbon metabolism_Homo sapiens_hsa012000.74980960
88Estrogen signaling pathway_Homo sapiens_hsa049150.74900417
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72952410
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72267367
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72161557
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69123155
93Serotonergic synapse_Homo sapiens_hsa047260.68354797
94Oocyte meiosis_Homo sapiens_hsa041140.68233576
95Long-term depression_Homo sapiens_hsa047300.67537348
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67473472
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66735745
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65935624
99Wnt signaling pathway_Homo sapiens_hsa043100.65906818
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.65897705
101Lysine degradation_Homo sapiens_hsa003100.65731557
102Parkinsons disease_Homo sapiens_hsa050120.65640351
103Melanoma_Homo sapiens_hsa052180.65285865
104Chronic myeloid leukemia_Homo sapiens_hsa052200.64688702
105Fatty acid metabolism_Homo sapiens_hsa012120.63962674
106cAMP signaling pathway_Homo sapiens_hsa040240.63353898
107Oxytocin signaling pathway_Homo sapiens_hsa049210.62939132
108AMPK signaling pathway_Homo sapiens_hsa041520.61866664
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61447070
110Glioma_Homo sapiens_hsa052140.60083800
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60074999
112Glycerolipid metabolism_Homo sapiens_hsa005610.58377571
113Glucagon signaling pathway_Homo sapiens_hsa049220.56806510
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.56360884
115Shigellosis_Homo sapiens_hsa051310.55836259
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55399129
117Colorectal cancer_Homo sapiens_hsa052100.54944771
118Salmonella infection_Homo sapiens_hsa051320.54674280
119Tryptophan metabolism_Homo sapiens_hsa003800.52600569
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52358146
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52049368
122Inositol phosphate metabolism_Homo sapiens_hsa005620.51141531
123Ovarian steroidogenesis_Homo sapiens_hsa049130.50697192
124Fatty acid biosynthesis_Homo sapiens_hsa000610.50365370
125Staphylococcus aureus infection_Homo sapiens_hsa051500.50249096
126ABC transporters_Homo sapiens_hsa020100.50132146
127Circadian rhythm_Homo sapiens_hsa047100.50130863
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48191469
129Taste transduction_Homo sapiens_hsa047420.48014519
130Insulin signaling pathway_Homo sapiens_hsa049100.47394458
131Arginine biosynthesis_Homo sapiens_hsa002200.47371424
132Prostate cancer_Homo sapiens_hsa052150.46860201
133Mineral absorption_Homo sapiens_hsa049780.44642858
134Tyrosine metabolism_Homo sapiens_hsa003500.43818265
135Gastric acid secretion_Homo sapiens_hsa049710.43497348
136Pyruvate metabolism_Homo sapiens_hsa006200.42258864
137Bile secretion_Homo sapiens_hsa049760.39712394
138Cell cycle_Homo sapiens_hsa041100.39186554
139Huntingtons disease_Homo sapiens_hsa050160.38996069
140MAPK signaling pathway_Homo sapiens_hsa040100.38916194
141Pancreatic cancer_Homo sapiens_hsa052120.37908294
142Endometrial cancer_Homo sapiens_hsa052130.37863094
143Bladder cancer_Homo sapiens_hsa052190.36813071
144TNF signaling pathway_Homo sapiens_hsa046680.36788780
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.36043592
146GnRH signaling pathway_Homo sapiens_hsa049120.36005665
147Fat digestion and absorption_Homo sapiens_hsa049750.35723060
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.34744540

Most similar genes based on co-expression Upload to Enrichr

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