APLN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelial tube morphogenesis (GO:0061154)7.93838629
2morphogenesis of an endothelium (GO:0003159)7.93838629
3negative regulation of blood vessel endothelial cell migration (GO:0043537)7.33963178
4doxorubicin metabolic process (GO:0044598)6.24678317
5daunorubicin metabolic process (GO:0044597)6.24678317
6polyketide metabolic process (GO:0030638)6.24678317
7angiogenesis involved in wound healing (GO:0060055)6.16898552
8wound healing, spreading of epidermal cells (GO:0035313)6.06333931
9sprouting angiogenesis (GO:0002040)5.86626556
10regulation of response to osmotic stress (GO:0047484)5.62508711
11regulation of cell migration involved in sprouting angiogenesis (GO:0090049)5.58412717
12central nervous system myelination (GO:0022010)5.41557536
13axon ensheathment in central nervous system (GO:0032291)5.41557536
14negative regulation of endothelial cell migration (GO:0010596)5.28624197
15glomerular filtration (GO:0003094)5.28193619
16positive regulation of endothelial cell differentiation (GO:0045603)5.23566252
17regulation of endothelial cell differentiation (GO:0045601)5.14775433
18regulation of blood vessel endothelial cell migration (GO:0043535)5.02366108
19renal filtration (GO:0097205)4.94491278
20patterning of blood vessels (GO:0001569)4.87712954
21Notch signaling involved in heart development (GO:0061314)4.78905132
22negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.63084064
23negative regulation of focal adhesion assembly (GO:0051895)4.48159589
24negative regulation of cell junction assembly (GO:1901889)4.48159589
25negative regulation of adherens junction organization (GO:1903392)4.48159589
26somite rostral/caudal axis specification (GO:0032525)4.47546128
27artery development (GO:0060840)4.45850619
28basement membrane organization (GO:0071711)4.42948703
29hyaluronan catabolic process (GO:0030214)4.17747799
30wound healing, spreading of cells (GO:0044319)4.17529085
31synaptic vesicle maturation (GO:0016188)4.13075527
32embryonic heart tube development (GO:0035050)4.12745934
33semaphorin-plexin signaling pathway (GO:0071526)4.11749390
34substrate-dependent cell migration (GO:0006929)4.10447465
35aminoglycoside antibiotic metabolic process (GO:0030647)4.05311479
36negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.00884869
37positive regulation of macrophage cytokine production (GO:0060907)3.92027037
38muscle organ morphogenesis (GO:0048644)3.90538703
39endothelial cell proliferation (GO:0001935)3.90497720
40maintenance of protein location in nucleus (GO:0051457)3.89769675
41regulation of endothelial cell migration (GO:0010594)3.87640775
42negative regulation of epithelial cell migration (GO:0010633)3.82636235
43endothelial cell morphogenesis (GO:0001886)3.79683918
44regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.77862277
45vasculogenesis (GO:0001570)3.76271494
46positive regulation of urine volume (GO:0035810)3.74646464
47myelin maintenance (GO:0043217)3.72106981
48nephron epithelium development (GO:0072009)3.71971879
49blood vessel endothelial cell migration (GO:0043534)3.71720995
50angiogenesis (GO:0001525)3.71529283
51phenol-containing compound catabolic process (GO:0019336)3.71356137
52proline transport (GO:0015824)3.70229529
53calcium-mediated signaling using intracellular calcium source (GO:0035584)3.67453560
54regulation of glomerular filtration (GO:0003093)3.63340790
55phagocytosis, recognition (GO:0006910)3.58683211
56labyrinthine layer development (GO:0060711)3.57790083
57neuron remodeling (GO:0016322)3.57591682
58positive regulation of endothelial cell migration (GO:0010595)3.56438992
59axon extension involved in axon guidance (GO:0048846)3.55730831
60neuron projection extension involved in neuron projection guidance (GO:1902284)3.55730831
61response to dietary excess (GO:0002021)3.54896866
62positive regulation of blood vessel endothelial cell migration (GO:0043536)3.51786467
63regulation of mammary gland epithelial cell proliferation (GO:0033599)3.48236024
64anatomical structure maturation (GO:0071695)3.47387810
65positive regulation of odontogenesis (GO:0042482)3.45128563
66negative regulation of potassium ion transmembrane transport (GO:1901380)3.43695440
67negative regulation of telomerase activity (GO:0051974)3.41329623
68negative regulation of epidermis development (GO:0045683)3.40393658
69notochord development (GO:0030903)3.39765898
70layer formation in cerebral cortex (GO:0021819)3.38479410
71venous blood vessel morphogenesis (GO:0048845)3.35423624
72endothelium development (GO:0003158)3.31162359
73peptidyl-tyrosine autophosphorylation (GO:0038083)3.28955714
74negative regulation of angiogenesis (GO:0016525)3.28460106
75blood vessel remodeling (GO:0001974)3.28378262
76primitive streak formation (GO:0090009)3.28004431
77vascular endothelial growth factor signaling pathway (GO:0038084)3.25976207
78negative regulation of platelet activation (GO:0010544)3.25071654
79endothelial cell migration (GO:0043542)3.24635338
80ganglion development (GO:0061548)3.24339798
81Notch receptor processing (GO:0007220)3.23563295
82endothelial cell chemotaxis (GO:0035767)3.23382896
83mRNA transcription from RNA polymerase II promoter (GO:0042789)3.22417496
84negative regulation of endothelial cell proliferation (GO:0001937)3.19130061
85cellular response to cholesterol (GO:0071397)3.19098451
86negative regulation of chondrocyte differentiation (GO:0032331)3.16045519
87ensheathment of neurons (GO:0007272)3.15398324
88axon ensheathment (GO:0008366)3.15398324
89negative regulation of blood vessel morphogenesis (GO:2000181)3.14972218
90regulation of epithelial cell migration (GO:0010632)3.10799037
91positive regulation of protein kinase C signaling (GO:0090037)3.09024370
92hormone catabolic process (GO:0042447)3.08815182
93myelination (GO:0042552)3.08031570
94lymph vessel development (GO:0001945)3.06892573
95positive regulation of epithelial cell migration (GO:0010634)3.03049441
96polarized epithelial cell differentiation (GO:0030859)3.01774945
97cell migration involved in gastrulation (GO:0042074)3.00681841
98negative regulation of vasculature development (GO:1901343)3.00479572
99positive regulation of endothelial cell proliferation (GO:0001938)2.99983406
100positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.99977786
101positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.99061467
102amino acid import (GO:0043090)2.95987383
103cell adhesion mediated by integrin (GO:0033627)2.95130361
104L-amino acid import (GO:0043092)2.94768699
105regulation of synapse maturation (GO:0090128)2.94142882
106blood vessel maturation (GO:0001955)2.93129590
107positive regulation of receptor recycling (GO:0001921)2.92928043
108plasma membrane fusion (GO:0045026)2.91019246
109anterior/posterior axis specification (GO:0009948)2.90650518
110negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.90166861
111negative regulation of smoothened signaling pathway (GO:0045879)2.86478626
112negative regulation of cell-substrate adhesion (GO:0010812)2.85858555
113regulation of adherens junction organization (GO:1903391)2.85602915
114regulation of focal adhesion assembly (GO:0051893)2.85151295
115regulation of cell-substrate junction assembly (GO:0090109)2.85151295
116surfactant homeostasis (GO:0043129)2.84328376
117cell fate commitment involved in formation of primary germ layer (GO:0060795)2.79933114
118heart trabecula morphogenesis (GO:0061384)2.79601065
119regulation of endothelial cell proliferation (GO:0001936)2.76763911
120detection of temperature stimulus (GO:0016048)2.76338697
121tachykinin receptor signaling pathway (GO:0007217)2.75506503
122endodermal cell differentiation (GO:0035987)2.75425780
123negative regulation of cell-matrix adhesion (GO:0001953)2.75233525
124negative regulation of catenin import into nucleus (GO:0035414)2.74343347
125vasculature development (GO:0001944)2.73560695
126ventricular system development (GO:0021591)2.73031288
127branching involved in salivary gland morphogenesis (GO:0060445)2.72279607
128dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.71698140
129regulation of vascular permeability (GO:0043114)2.71624572
130cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.71383054
131regulation of apoptotic process involved in morphogenesis (GO:1902337)2.71239106
132retina vasculature morphogenesis in camera-type eye (GO:0061299)2.70657865
133ventricular trabecula myocardium morphogenesis (GO:0003222)2.68255978
134positive regulation of Rap GTPase activity (GO:0032854)2.67617194
135endochondral ossification (GO:0001958)2.67039892
136replacement ossification (GO:0036075)2.67039892
137histone H4-K8 acetylation (GO:0043982)2.66691221
138histone H4-K5 acetylation (GO:0043981)2.66691221
139positive regulation of chondrocyte differentiation (GO:0032332)2.66054562
140branching involved in mammary gland duct morphogenesis (GO:0060444)2.62279669
141positive regulation of histone deacetylation (GO:0031065)2.62060052
142potassium ion import (GO:0010107)2.60522576
143regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.60419031
144cardiovascular system development (GO:0072358)2.58138632
145trabecula morphogenesis (GO:0061383)2.57236331
146establishment of endothelial barrier (GO:0061028)2.56808054
147endothelial cell differentiation (GO:0045446)2.56805463
148neurotransmitter uptake (GO:0001504)2.55831452
149lateral sprouting from an epithelium (GO:0060601)2.55825414
150ovulation cycle (GO:0042698)2.55799606
151anterior/posterior axis specification, embryo (GO:0008595)2.54739588
152microtubule severing (GO:0051013)2.54595005
153positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.53916993
154cardiac muscle cell proliferation (GO:0060038)2.52896985
155bone trabecula formation (GO:0060346)2.52459979
156coenzyme catabolic process (GO:0009109)2.50883348
157vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.48768574
158epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45781123
159cell migration involved in sprouting angiogenesis (GO:0002042)2.45300410
160negative regulation of DNA biosynthetic process (GO:2000279)2.45219137
161protein localization to endosome (GO:0036010)2.44715808
162negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.44193871
163vitamin A metabolic process (GO:0006776)2.42347417
164negative regulation of protein localization to cell surface (GO:2000009)2.42315641
165mitochondrion distribution (GO:0048311)2.42148589
166negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.41310536
167mammary gland development (GO:0030879)2.40748407
168cellular response to sterol (GO:0036315)2.40722955
169positive regulation of vasculogenesis (GO:2001214)2.40705901
170negative regulation of cell fate commitment (GO:0010454)2.39979393
171heme transport (GO:0015886)2.39728898
172striated muscle cell proliferation (GO:0014855)2.38534363
173negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.38442946
174regulation of Rap GTPase activity (GO:0032317)2.36760226
175negative regulation of epidermal cell differentiation (GO:0045605)2.36364486
176regulation of vasculogenesis (GO:2001212)2.35140510
177icosanoid secretion (GO:0032309)2.34990355
178arachidonic acid secretion (GO:0050482)2.34990355
179transepithelial transport (GO:0070633)2.33828837
180positive regulation of protein deacetylation (GO:0090312)2.33182994
181lymphangiogenesis (GO:0001946)2.32580864
182extracellular matrix assembly (GO:0085029)2.32473012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.89745373
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.89745373
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.89745373
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.88687327
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.70905478
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.63279155
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.55148842
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.42906518
9SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.30951672
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.29838289
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28446601
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.24978003
13* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17400374
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17400374
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11885510
16CLOCK_20551151_ChIP-Seq_293T_Human2.11837396
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.11510798
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.09146725
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.02813460
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.02566406
21* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01672069
22TCF3_18692474_ChIP-Seq_MESCs_Mouse2.00368428
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.99851823
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.97846114
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.96501424
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95525562
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94369314
28* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93353789
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.84478595
30* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84089785
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.80046805
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76572431
33NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.72689576
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.71914291
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70547519
36LXR_22292898_ChIP-Seq_THP-1_Human1.70167086
37RING1B_27294783_Chip-Seq_NPCs_Mouse1.66311440
38KDM2B_26808549_Chip-Seq_K562_Human1.64529064
39NFIB_24661679_ChIP-Seq_LUNG_Mouse1.60022298
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55435338
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55333455
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.54962353
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54008177
44* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53998593
45* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53499634
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53190491
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52575722
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.50093781
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49657950
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48609455
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.47757923
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.45962655
53TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.45398509
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42084000
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41823683
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41631240
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.41459150
58* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40920398
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.40174327
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37997315
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36739564
62POU5F1_16518401_ChIP-PET_MESCs_Mouse1.36682995
63PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.35811792
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35611397
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34731250
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.31980935
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30606009
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30258066
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29805768
70* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28563937
71SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27656144
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27271911
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25004825
74TP53_23651856_ChIP-Seq_MEFs_Mouse1.23622914
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21778704
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.18234538
77NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18065564
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.17879221
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.17218052
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17185513
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.17085687
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.17049805
83SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16214803
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16173643
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15759299
86CDX2_20551321_ChIP-Seq_CACO-2_Human1.15483490
87NANOG_18692474_ChIP-Seq_MESCs_Mouse1.15454873
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.13880747
89KDM2B_26808549_Chip-Seq_DND41_Human1.13516319
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12661549
91SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11988422
92EOMES_21245162_ChIP-Seq_HESCs_Human1.11935532
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11796554
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11582919
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11520635
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.11193038
97ELK3_25401928_ChIP-Seq_HUVEC_Human1.11046104
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10778170
99SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10379134
100POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10036591
101RARB_27405468_Chip-Seq_BRAIN_Mouse1.09889456
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09441937
103UBF1/2_26484160_Chip-Seq_HMECs_Human1.08265642
104FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06979147
105TP63_17297297_ChIP-ChIP_HaCaT_Human1.06821690
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05874234
107TCF7_22412390_ChIP-Seq_EML_Mouse1.05000044
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04871225
109TP53_22127205_ChIP-Seq_IMR90_Human1.03717480
110* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02926305
111ZNF263_19887448_ChIP-Seq_K562_Human1.02347087
112IRF1_19129219_ChIP-ChIP_H3396_Human1.01730875
113DROSHA_22980978_ChIP-Seq_HELA_Human1.01216274
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00573583
115TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00464602
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00027590
117TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99884225
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99592639
119PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99586652
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99314080
121BRD4_25478319_ChIP-Seq_HGPS_Human0.97686258
122ESR1_21235772_ChIP-Seq_MCF-7_Human0.97527568
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97260609
124CJUN_26792858_Chip-Seq_BT549_Human0.96948886
125CTCF_27219007_Chip-Seq_Bcells_Human0.96777240
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96377122
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94332684
128P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94326412
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.94130101
130SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93903434
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.91943608
132RACK7_27058665_Chip-Seq_MCF-7_Human0.91339582
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90755247
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89631048
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89536265
136NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88222147
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88220779
138SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88220779
139KLF5_25053715_ChIP-Seq_YYC3_Human0.87431987
140NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87221916
141RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86545310
142TBX20_22328084_ChIP-Seq_HEART_Mouse0.86145197
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.86145197
144AHR_22903824_ChIP-Seq_MCF-7_Human0.85739139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane3.51783663
2MP0004858_abnormal_nervous_system3.46961705
3MP0002254_reproductive_system_inflammat3.33751401
4MP0005623_abnormal_meninges_morphology3.25353032
5MP0005409_darkened_coat_color2.91934900
6MP0000465_gastrointestinal_hemorrhage2.79339680
7MP0003705_abnormal_hypodermis_morpholog2.73584788
8MP0003011_delayed_dark_adaptation2.72492231
9MP0003303_peritoneal_inflammation2.62120323
10MP0005167_abnormal_blood-brain_barrier2.61738591
11MP0003122_maternal_imprinting2.59328270
12MP0010368_abnormal_lymphatic_system2.52928352
13MP0002138_abnormal_hepatobiliary_system2.40439859
14MP0003890_abnormal_embryonic-extraembry2.37351108
15MP0010030_abnormal_orbit_morphology2.05455303
16MP0005394_taste/olfaction_phenotype2.01025719
17MP0005499_abnormal_olfactory_system2.01025719
18MP0003566_abnormal_cell_adhesion2.00115527
19MP0003950_abnormal_plasma_membrane1.96781994
20MP0005171_absent_coat_pigmentation1.94806551
21MP0000013_abnormal_adipose_tissue1.88341087
22* MP0002332_abnormal_exercise_endurance1.80222485
23MP0002127_abnormal_cardiovascular_syste1.79689033
24MP0003283_abnormal_digestive_organ1.79417027
25MP0001915_intracranial_hemorrhage1.78935712
26MP0001879_abnormal_lymphatic_vessel1.77302102
27MP0003136_yellow_coat_color1.72984770
28MP0002653_abnormal_ependyma_morphology1.62911120
29MP0004084_abnormal_cardiac_muscle1.61960860
30MP0002877_abnormal_melanocyte_morpholog1.61221352
31MP0000920_abnormal_myelination1.55445533
32MP0003137_abnormal_impulse_conducting1.54792516
33MP0004264_abnormal_extraembryonic_tissu1.54425043
34MP0000762_abnormal_tongue_morphology1.52059254
35MP0003279_aneurysm1.50873885
36MP0004782_abnormal_surfactant_physiolog1.49563796
37MP0002932_abnormal_joint_morphology1.47161305
38MP0003300_gastrointestinal_ulcer1.46598190
39MP0002933_joint_inflammation1.45544312
40MP0003724_increased_susceptibility_to1.41853556
41MP0000249_abnormal_blood_vessel1.41207236
42MP0008438_abnormal_cutaneous_collagen1.40787593
43MP0000049_abnormal_middle_ear1.39078957
44MP0004859_abnormal_synaptic_plasticity1.37639293
45MP0003690_abnormal_glial_cell1.36356312
46MP0004233_abnormal_muscle_weight1.34352897
47MP0001486_abnormal_startle_reflex1.33037840
48MP0004270_analgesia1.32233890
49MP0002128_abnormal_blood_circulation1.31919726
50MP0000750_abnormal_muscle_regeneration1.30078591
51MP0002233_abnormal_nose_morphology1.27629681
52MP0006138_congestive_heart_failure1.26591930
53MP0006292_abnormal_olfactory_placode1.26487930
54MP0002925_abnormal_cardiovascular_devel1.23871356
55MP0004043_abnormal_pH_regulation1.23392754
56MP0003121_genomic_imprinting1.23387472
57MP0000428_abnormal_craniofacial_morphol1.22993690
58MP0003935_abnormal_craniofacial_develop1.22488386
59MP0003634_abnormal_glial_cell1.22068171
60MP0003938_abnormal_ear_development1.21918887
61MP0004145_abnormal_muscle_electrophysio1.21311456
62MP0006054_spinal_hemorrhage1.20069509
63MP0004085_abnormal_heartbeat1.17312480
64MP0005508_abnormal_skeleton_morphology1.16185422
65MP0000749_muscle_degeneration1.15533181
66MP0002249_abnormal_larynx_morphology1.15340690
67MP0010678_abnormal_skin_adnexa1.14599749
68MP0005257_abnormal_intraocular_pressure1.14377450
69MP0005330_cardiomyopathy1.14132561
70MP0004885_abnormal_endolymph1.10684909
71MP0003937_abnormal_limbs/digits/tail_de1.09931417
72MP0003755_abnormal_palate_morphology1.08862445
73MP0010630_abnormal_cardiac_muscle1.07705599
74MP0001849_ear_inflammation1.05478108
75MP0003984_embryonic_growth_retardation1.04281678
76MP0001672_abnormal_embryogenesis/_devel1.04256305
77MP0005380_embryogenesis_phenotype1.04256305
78MP0000383_abnormal_hair_follicle1.03858115
79MP0002088_abnormal_embryonic_growth/wei1.03674595
80MP0001348_abnormal_lacrimal_gland1.02725114
81MP0000778_abnormal_nervous_system1.01933466
82MP0000432_abnormal_head_morphology1.00887134
83MP0003091_abnormal_cell_migration0.99975793
84MP0000003_abnormal_adipose_tissue0.99364410
85MP0008961_abnormal_basal_metabolism0.97795795
86MP0009250_abnormal_appendicular_skeleto0.96003720
87MP0001784_abnormal_fluid_regulation0.95445342
88MP0001958_emphysema0.95406491
89MP0000678_abnormal_parathyroid_gland0.95380165
90MP0004087_abnormal_muscle_fiber0.93070991
91MP0004133_heterotaxia0.92147041
92MP0000955_abnormal_spinal_cord0.91730386
93* MP0004215_abnormal_myocardial_fiber0.90643626
94MP0000767_abnormal_smooth_muscle0.89829156
95MP0004883_abnormal_blood_vessel0.89244105
96MP0009697_abnormal_copulation0.88976551
97* MP0002972_abnormal_cardiac_muscle0.88809622
98MP0010352_gastrointestinal_tract_polyps0.88267894
99MP0003828_pulmonary_edema0.87897846
100MP0000733_abnormal_muscle_development0.87606029
101MP0002114_abnormal_axial_skeleton0.86556973
102MP0002064_seizures0.86471223
103MP0003635_abnormal_synaptic_transmissio0.86015523
104MP0002116_abnormal_craniofacial_bone0.85093418
105MP0000537_abnormal_urethra_morphology0.84608069
106* MP0001614_abnormal_blood_vessel0.83397810
107MP0003941_abnormal_skin_development0.80342901
108* MP0005620_abnormal_muscle_contractility0.80095345
109MP0005084_abnormal_gallbladder_morpholo0.79005373
110MP0002295_abnormal_pulmonary_circulatio0.77706551
111MP0000534_abnormal_ureter_morphology0.77696505
112* MP0005165_increased_susceptibility_to0.77361851
113MP0003861_abnormal_nervous_system0.77253000
114MP0003633_abnormal_nervous_system0.77080565
115MP0000759_abnormal_skeletal_muscle0.76617537
116MP0008770_decreased_survivor_rate0.75677766
117MP0002086_abnormal_extraembryonic_tissu0.75478962
118MP0002085_abnormal_embryonic_tissue0.74757318
119MP0003329_amyloid_beta_deposits0.74476013
120MP0005197_abnormal_uvea_morphology0.74471911
121MP0003045_fibrosis0.74197186
122MP0003632_abnormal_nervous_system0.74007131
123MP0005595_abnormal_vascular_smooth0.73694547
124MP0004036_abnormal_muscle_relaxation0.73655637
125* MP0002092_abnormal_eye_morphology0.73465583
126MP0000343_altered_response_to0.73200237
127MP0000266_abnormal_heart_morphology0.70145325
128MP0003075_altered_response_to0.68782303
129MP0005023_abnormal_wound_healing0.68196528
130MP0002697_abnormal_eye_size0.67915163
131MP0005388_respiratory_system_phenotype0.66369227
132MP0002133_abnormal_respiratory_system0.66369227
133MP0009780_abnormal_chondrocyte_physiolo0.66289975
134MP0003385_abnormal_body_wall0.64269299
135MP0009053_abnormal_anal_canal0.63358450
136MP0004510_myositis0.61861891
137MP0002896_abnormal_bone_mineralization0.60437890
138MP0001544_abnormal_cardiovascular_syste0.59437950
139MP0005385_cardiovascular_system_phenoty0.59437950
140MP0003868_abnormal_feces_composition0.55217488
141MP0000467_abnormal_esophagus_morphology0.55067832
142MP0000613_abnormal_salivary_gland0.51386809
143MP0000747_muscle_weakness0.50618114
144MP0000751_myopathy0.50174926
145* MP0004484_altered_response_of0.49296199
146MP0002796_impaired_skin_barrier0.48871708
147MP0003631_nervous_system_phenotype0.48423369
148* MP0003948_abnormal_gas_homeostasis0.46775344
149MP0005193_abnormal_anterior_eye0.45113942
150MP0005058_abnormal_lysosome_morphology0.44144805
151MP0002168_other_aberrant_phenotype0.43666595

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)6.06494239
2Nonimmune hydrops fetalis (HP:0001790)6.00394372
3Hematochezia (HP:0002573)5.96805668
4Bilateral microphthalmos (HP:0007633)5.60750273
5Esophageal varix (HP:0002040)5.44062995
6Polycythemia (HP:0001901)4.97044803
7Skull defect (HP:0001362)4.74436486
8Cerebral aneurysm (HP:0004944)4.72587306
9Wrist flexion contracture (HP:0001239)4.65853656
10Cerebral hemorrhage (HP:0001342)4.65447953
11Conjunctival telangiectasia (HP:0000524)4.45879674
12Arterial tortuosity (HP:0005116)4.42525912
13Vascular tortuosity (HP:0004948)3.96900928
14Hypochromic microcytic anemia (HP:0004840)3.80048398
15Adactyly (HP:0009776)3.79043650
16Portal hypertension (HP:0001409)3.76551083
17Spinal rigidity (HP:0003306)3.60829015
18Tetraparesis (HP:0002273)3.60167807
19Abnormality of the vasculature of the conjunctiva (HP:0008054)3.57834320
20Difficulty running (HP:0009046)3.56186995
21Abnormality of the nasal mucosa (HP:0000433)3.55929658
22Hepatoblastoma (HP:0002884)3.52216221
23Rib fusion (HP:0000902)3.46195610
24Abnormality of the hepatic vasculature (HP:0006707)3.42863005
25Abnormality of the lower motor neuron (HP:0002366)3.36271771
26Porencephaly (HP:0002132)3.34106429
27Overgrowth (HP:0001548)3.21392706
28Hemiparesis (HP:0001269)3.20854132
29Absent hand (HP:0004050)3.11992236
30Difficulty climbing stairs (HP:0003551)3.10740323
31Vertebral clefting (HP:0008428)3.08277272
32Partial duplication of thumb phalanx (HP:0009944)3.06282791
33Multiple enchondromatosis (HP:0005701)3.02472914
34Fused cervical vertebrae (HP:0002949)3.02418150
35Myotonia (HP:0002486)3.01509215
36Neonatal death (HP:0003811)3.00451233
37Partial duplication of the phalanx of hand (HP:0009999)2.88444442
38Exercise-induced muscle cramps (HP:0003710)2.87243165
39Hemorrhage of the eye (HP:0011885)2.85338865
40Abnormal vertebral ossification (HP:0100569)2.79733807
41Hemiplegia (HP:0002301)2.74643448
42Hyperinsulinemic hypoglycemia (HP:0000825)2.73344115
43Abnormality of the salivary glands (HP:0010286)2.72227282
44Hyporeflexia of lower limbs (HP:0002600)2.70450391
45Bifid tongue (HP:0010297)2.68173423
46Aplasia involving bones of the upper limbs (HP:0009823)2.65601279
47Aplasia of the phalanges of the hand (HP:0009802)2.65601279
48Aplasia involving bones of the extremities (HP:0009825)2.65601279
49Stroke (HP:0001297)2.64368431
50Premature rupture of membranes (HP:0001788)2.62463019
51Generalized hypotonia (HP:0001290)2.59110800
52Short humerus (HP:0005792)2.58488443
53Short 4th metacarpal (HP:0010044)2.55265754
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.55265754
55Capillary hemangiomas (HP:0005306)2.55074239
56Venous insufficiency (HP:0005293)2.54798187
57Neurofibrillary tangles (HP:0002185)2.53583321
58Abnormal auditory evoked potentials (HP:0006958)2.52849526
59Sensory axonal neuropathy (HP:0003390)2.48694678
60Cavernous hemangioma (HP:0001048)2.47836630
61Menorrhagia (HP:0000132)2.44418223
62Aplasia/hypoplasia of the humerus (HP:0006507)2.42790144
63Aortic dissection (HP:0002647)2.38907087
64Broad metatarsal (HP:0001783)2.35681306
65Increased variability in muscle fiber diameter (HP:0003557)2.35520865
66Large earlobe (HP:0009748)2.33299204
67Megalencephaly (HP:0001355)2.31845724
68Preaxial foot polydactyly (HP:0001841)2.31687419
69Renal duplication (HP:0000075)2.28347925
70Increased connective tissue (HP:0009025)2.27663337
71Pulmonary hypertension (HP:0002092)2.27442064
72High pitched voice (HP:0001620)2.27395498
73Ependymoma (HP:0002888)2.26798419
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.26275432
75Astrocytoma (HP:0009592)2.24570107
76Abnormality of the astrocytes (HP:0100707)2.24570107
77Cervical subluxation (HP:0003308)2.22019557
78Venous abnormality (HP:0002624)2.21796587
79Protrusio acetabuli (HP:0003179)2.21438874
80Hypopigmentation of the fundus (HP:0007894)2.21102997
81Hyperventilation (HP:0002883)2.21078231
82Abnormality of chromosome segregation (HP:0002916)2.20952178
83Ectopia lentis (HP:0001083)2.19573748
84Aortic valve stenosis (HP:0001650)2.18912189
85Mildly elevated creatine phosphokinase (HP:0008180)2.17643328
86Tracheal stenosis (HP:0002777)2.16477993
87Abnormality of the pubic bones (HP:0003172)2.15813684
88Mucosal telangiectasiae (HP:0100579)2.15443555
89Joint contractures involving the joints of the feet (HP:0100492)2.14705694
90Flexion contracture of toe (HP:0005830)2.14705694
91Aortic aneurysm (HP:0004942)2.14673109
92Coxa vara (HP:0002812)2.12267600
93Distal lower limb muscle weakness (HP:0009053)2.12097493
94Broad face (HP:0000283)2.11313059
95Neoplasm of the heart (HP:0100544)2.10835207
96Disproportionate tall stature (HP:0001519)2.10771126
97Buphthalmos (HP:0000557)2.09308662
98Neoplasm of striated muscle (HP:0009728)2.09028133
99Rectovaginal fistula (HP:0000143)2.08532170
100Rectal fistula (HP:0100590)2.08532170
101Abnormality of the corticospinal tract (HP:0002492)2.08048032
102Abnormal platelet function (HP:0011869)2.07973755
103Impaired platelet aggregation (HP:0003540)2.07973755
104Resting tremor (HP:0002322)2.07362506
105Hip contracture (HP:0003273)2.07315548
106Centrally nucleated skeletal muscle fibers (HP:0003687)2.05872286
107Amblyopia (HP:0000646)2.05468443
108Apathy (HP:0000741)2.04080071
109Cerebral inclusion bodies (HP:0100314)2.03754362
110Nuclear cataract (HP:0100018)2.03492552
111Preauricular pit (HP:0004467)2.03008655
112Periauricular skin pits (HP:0100277)2.03008655
113Abnormality of the distal phalanx of the thumb (HP:0009617)2.02435628
114Mask-like facies (HP:0000298)2.02118666
115Pseudobulbar signs (HP:0002200)2.00653060
116Blue sclerae (HP:0000592)2.00564146
117Trismus (HP:0000211)1.99427221
118Atrial fibrillation (HP:0005110)1.98951544
119Abnormality of the 4th metacarpal (HP:0010012)1.98680786
120Polygenic inheritance (HP:0010982)1.98373568
121Abnormality of the pulmonary veins (HP:0011718)1.96452027
122Hydroureter (HP:0000072)1.96336657
123Abnormality of the intrinsic pathway (HP:0010989)1.95109160
124Lymphangioma (HP:0100764)1.94958097
125Visceral angiomatosis (HP:0100761)1.94402243
126Abnormality of oral frenula (HP:0000190)1.93133482
127Wormian bones (HP:0002645)1.92847643
128Anomalous pulmonary venous return (HP:0010772)1.92456325
129Abnormality of the musculature of the hand (HP:0001421)1.91808609
130Aneurysm (HP:0002617)1.91109046
131Ventricular tachycardia (HP:0004756)1.91046723
132Lymphedema (HP:0001004)1.90951692
133Limited hip movement (HP:0008800)1.88617761
134Ankyloglossia (HP:0010296)1.87369321
135Pancreatic islet-cell hyperplasia (HP:0004510)1.87098297
136Horizontal nystagmus (HP:0000666)1.87075225
137Abnormal lung lobation (HP:0002101)1.86715054
138Hemangiomatosis (HP:0007461)1.85878221
139Onion bulb formation (HP:0003383)1.85624266
140Testicular atrophy (HP:0000029)1.85155944
141Short 5th finger (HP:0009237)1.84734969
142Supraventricular arrhythmia (HP:0005115)1.84625103
143Primary atrial arrhythmia (HP:0001692)1.84587163
144Diminished motivation (HP:0000745)1.84501014
145Nasolacrimal duct obstruction (HP:0000579)1.83561063
146Achilles tendon contracture (HP:0001771)1.82610688
147Nephroblastoma (Wilms tumor) (HP:0002667)1.81992503
148Absent eyebrow (HP:0002223)1.81111582
149Increased serum pyruvate (HP:0003542)1.79950962
150Abnormality of glycolysis (HP:0004366)1.79950962
151Upper limb amyotrophy (HP:0009129)1.78904196
152Distal upper limb amyotrophy (HP:0007149)1.78904196
153Abnormality of skeletal muscle fiber size (HP:0012084)1.78627329
154Neoplasm of the oral cavity (HP:0100649)1.77736795
155Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77475476
156Congenital cataract (HP:0000519)1.77144725
157Vitreoretinal degeneration (HP:0000655)1.76897445
158Prominent occiput (HP:0000269)1.74919148
159Intention tremor (HP:0002080)1.74811815
160Amyotrophic lateral sclerosis (HP:0007354)1.74192551
161Shawl scrotum (HP:0000049)1.73985975
162Clumsiness (HP:0002312)1.73009008
163Stenosis of the external auditory canal (HP:0000402)1.72953747
164Supraventricular tachycardia (HP:0004755)1.72697015
165Vaginal fistula (HP:0004320)1.72063454
166Shallow orbits (HP:0000586)1.70650707
167Lumbar hyperlordosis (HP:0002938)1.70573806
168Embryonal renal neoplasm (HP:0011794)1.69968939
169Muscle fiber splitting (HP:0003555)1.69838446
170Intestinal fistula (HP:0100819)1.68619532
171Macroorchidism (HP:0000053)1.68303729
172Joint hemorrhage (HP:0005261)1.67294167
173Mitral valve prolapse (HP:0001634)1.66951502
174Hypoplasia of the iris (HP:0007676)1.66684183
175Congenital hip dislocation (HP:0001374)1.66650697
176Rapidly progressive (HP:0003678)1.66106554
177Vertebral fusion (HP:0002948)1.65767766
178Absent eyelashes (HP:0000561)1.65387215
179Preauricular skin tag (HP:0000384)1.64564674
180Anterior segment dysgenesis (HP:0007700)1.64321893
181Short nail (HP:0001799)1.64250000
182Abnormality of the phalanges of the hallux (HP:0010057)1.63984607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.77676357
2GRK54.24755605
3TYRO33.02636602
4FES2.98924623
5KDR2.91977780
6ERN12.75056481
7GRK12.71246834
8TIE12.70843519
9GRK62.62218243
10WNK12.46890268
11TGFBR22.39419261
12EPHB22.37859734
13NTRK12.27475817
14PRKD32.01992951
15STK391.98894346
16ADRBK21.92029971
17MAPK71.88647983
18PRKG21.70066707
19MOS1.69964629
20TGFBR11.64320472
21GRK71.60595332
22CSF1R1.58791900
23PDGFRA1.54326457
24MARK21.50268005
25MATK1.48134580
26RIPK11.48068999
27PAK61.38966493
28LATS21.27242928
29STK101.23595132
30FGFR21.23008701
31PAK41.22771664
32SIK11.18813571
33LMTK21.16309372
34PHKG21.15421907
35PHKG11.15421907
36CAMK41.14947297
37DDR21.14773320
38NTRK21.12411814
39MAPK121.05746555
40OXSR11.02760169
41EPHA41.00958038
42DMPK0.99179700
43BMX0.95775189
44PAK30.94956357
45PTK2B0.94812084
46ADRBK10.93113856
47ERBB40.92243220
48PRKD10.92153509
49TRIB30.92122621
50UHMK10.89093148
51CSK0.88793849
52ALK0.87414514
53MAP2K40.86260182
54TTK0.83058246
55MET0.82304538
56ARAF0.78658640
57PTK20.76185696
58PKN10.76174669
59MAPKAPK50.75867216
60HIPK20.74067538
61ROCK20.73883442
62MAP2K30.73528425
63PRKCH0.73081019
64WNK40.72725331
65CAMK1G0.71648933
66IRAK30.71431851
67MAP3K70.70482793
68LRRK20.68996006
69TTN0.68528561
70TESK10.67677349
71EEF2K0.67497593
72MAP3K110.67057485
73AKT20.66869324
74FLT30.65579840
75PDGFRB0.63775148
76MAP3K90.63616101
77FGFR40.63367986
78CDK140.63160577
79PTK60.63117919
80PAK20.59890913
81EPHB10.59886908
82PRKD20.59465745
83PDK20.58798437
84ROCK10.56832183
85KSR20.56235346
86FGFR30.56032082
87IGF1R0.55861706
88CDK150.54069214
89ZAP700.53588754
90CDK50.52193771
91SMG10.51532326
92TRPM70.50670585
93EPHA20.49460234
94MAP3K130.49151244
95GSK3A0.49050385
96DAPK30.47563435
97FGR0.47012616
98RPS6KA20.46821110
99CDK180.46745104
100SRC0.45603552
101ILK0.45562973
102NTRK30.44960968
103MAP3K10.43276619
104TEC0.42585200
105CDK11A0.42150864
106ITK0.42101567
107PDK40.41755036
108PDK30.41755036
109INSR0.40688863
110HCK0.40357920
111MTOR0.39319456
112BCR0.38926365
113MUSK0.38809210
114PAK10.38659544
115FER0.37810563
116CAMK1D0.37277259
117MAPK100.36611616
118FGFR10.36488596
119IRAK20.36448029
120MAPKAPK30.34526932
121ICK0.33407123
122ERBB20.33245680
123PRKAA20.32354816
124CDK190.32321804
125LIMK10.30351258
126PKN20.28116536
127RET0.27919596
128JAK30.27340887
129TESK20.25177443
130PDPK10.24673362
131MAP3K30.24227233
132EGFR0.23892600
133MARK10.22990508
134SGK2230.21401828
135SGK4940.21401828
136ABL20.20959634
137MAP3K120.19922778
138SGK30.18568889
139CDK90.14900365
140MAP3K100.12759645
141MAP3K80.11964708
142CAMK2B0.11614701
143KSR10.11230085
144FYN0.09228749

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.67666227
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.42479933
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.32306027
4Vitamin B6 metabolism_Homo sapiens_hsa007503.26125948
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.91374543
6Fatty acid biosynthesis_Homo sapiens_hsa000611.90791817
7Prion diseases_Homo sapiens_hsa050201.75601628
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67279714
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.66099947
10GABAergic synapse_Homo sapiens_hsa047271.65846298
11Dilated cardiomyopathy_Homo sapiens_hsa054141.63873125
12Glutamatergic synapse_Homo sapiens_hsa047241.61034115
13Rap1 signaling pathway_Homo sapiens_hsa040151.56807581
14Axon guidance_Homo sapiens_hsa043601.53819697
15Amoebiasis_Homo sapiens_hsa051461.52480949
16Phospholipase D signaling pathway_Homo sapiens_hsa040721.49383591
17ECM-receptor interaction_Homo sapiens_hsa045121.41636026
18Tight junction_Homo sapiens_hsa045301.40457784
19Focal adhesion_Homo sapiens_hsa045101.39761585
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39741486
21Basal cell carcinoma_Homo sapiens_hsa052171.39052247
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36819357
23Ether lipid metabolism_Homo sapiens_hsa005651.36670369
24Dorso-ventral axis formation_Homo sapiens_hsa043201.35094966
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31181781
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30508344
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29599274
28Pancreatic cancer_Homo sapiens_hsa052121.27859517
29Hedgehog signaling pathway_Homo sapiens_hsa043401.27062629
30Renal cell carcinoma_Homo sapiens_hsa052111.26155415
31Fructose and mannose metabolism_Homo sapiens_hsa000511.25796932
32Platelet activation_Homo sapiens_hsa046111.24092051
33Ras signaling pathway_Homo sapiens_hsa040141.22990272
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.22785518
35Hippo signaling pathway_Homo sapiens_hsa043901.21565754
36Ovarian steroidogenesis_Homo sapiens_hsa049131.21281522
37Linoleic acid metabolism_Homo sapiens_hsa005911.19010816
38Proteoglycans in cancer_Homo sapiens_hsa052051.15766686
39Adherens junction_Homo sapiens_hsa045201.14542664
40Chronic myeloid leukemia_Homo sapiens_hsa052201.13164749
41Long-term depression_Homo sapiens_hsa047301.11367799
42Gastric acid secretion_Homo sapiens_hsa049711.10342949
43Gap junction_Homo sapiens_hsa045401.08809561
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07226778
45Shigellosis_Homo sapiens_hsa051311.07039206
46Cardiac muscle contraction_Homo sapiens_hsa042601.05762660
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.04930232
48VEGF signaling pathway_Homo sapiens_hsa043701.04031650
49Melanogenesis_Homo sapiens_hsa049161.03969073
50Pathways in cancer_Homo sapiens_hsa052001.02968028
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.01314034
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.00435161
53Estrogen signaling pathway_Homo sapiens_hsa049150.99945610
54Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99247208
55TGF-beta signaling pathway_Homo sapiens_hsa043500.99112275
56Renin secretion_Homo sapiens_hsa049240.98950709
57Thyroid cancer_Homo sapiens_hsa052160.98051959
58Vibrio cholerae infection_Homo sapiens_hsa051100.97824146
59Arachidonic acid metabolism_Homo sapiens_hsa005900.97788729
60Arginine biosynthesis_Homo sapiens_hsa002200.97440589
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.96798631
62Salivary secretion_Homo sapiens_hsa049700.96564612
63Oxytocin signaling pathway_Homo sapiens_hsa049210.95812596
64Wnt signaling pathway_Homo sapiens_hsa043100.94437440
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94391095
66Malaria_Homo sapiens_hsa051440.93523305
67Serotonergic synapse_Homo sapiens_hsa047260.93254412
68Complement and coagulation cascades_Homo sapiens_hsa046100.90819226
69cAMP signaling pathway_Homo sapiens_hsa040240.90457163
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90343916
71Choline metabolism in cancer_Homo sapiens_hsa052310.90248963
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89945720
73GnRH signaling pathway_Homo sapiens_hsa049120.88572591
74Circadian entrainment_Homo sapiens_hsa047130.88517138
75Protein digestion and absorption_Homo sapiens_hsa049740.87660779
76Galactose metabolism_Homo sapiens_hsa000520.87490345
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86999787
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.86625468
79Salmonella infection_Homo sapiens_hsa051320.85791350
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84434227
81Long-term potentiation_Homo sapiens_hsa047200.81859960
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81433747
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80756569
84Morphine addiction_Homo sapiens_hsa050320.76504516
85mTOR signaling pathway_Homo sapiens_hsa041500.76334252
86Calcium signaling pathway_Homo sapiens_hsa040200.76115223
87Notch signaling pathway_Homo sapiens_hsa043300.75587355
88Glioma_Homo sapiens_hsa052140.74988360
89MicroRNAs in cancer_Homo sapiens_hsa052060.73808529
90Pertussis_Homo sapiens_hsa051330.73125231
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73012676
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72012421
93Bile secretion_Homo sapiens_hsa049760.71267028
94Endocytosis_Homo sapiens_hsa041440.70801984
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70725750
96Fatty acid elongation_Homo sapiens_hsa000620.70604314
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70147318
98Bladder cancer_Homo sapiens_hsa052190.68603010
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67067163
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65894186
101Dopaminergic synapse_Homo sapiens_hsa047280.65751227
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65243028
103Taste transduction_Homo sapiens_hsa047420.65094505
104Cocaine addiction_Homo sapiens_hsa050300.64779318
105Colorectal cancer_Homo sapiens_hsa052100.64645747
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64431158
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.64188272
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63476737
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62700033
110MAPK signaling pathway_Homo sapiens_hsa040100.62197612
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62194459
112Fatty acid metabolism_Homo sapiens_hsa012120.61844883
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61073225
114Melanoma_Homo sapiens_hsa052180.60682876
115Cholinergic synapse_Homo sapiens_hsa047250.60291916
116ErbB signaling pathway_Homo sapiens_hsa040120.59337638
117Small cell lung cancer_Homo sapiens_hsa052220.58846690
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58535816
119Other glycan degradation_Homo sapiens_hsa005110.57011332
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55136284
121AMPK signaling pathway_Homo sapiens_hsa041520.55001108
122Inositol phosphate metabolism_Homo sapiens_hsa005620.54237239
123Insulin secretion_Homo sapiens_hsa049110.53230769
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.52710594
125HIF-1 signaling pathway_Homo sapiens_hsa040660.52701145
126Arginine and proline metabolism_Homo sapiens_hsa003300.51173827
127Non-small cell lung cancer_Homo sapiens_hsa052230.51009111
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49842215
129Thyroid hormone synthesis_Homo sapiens_hsa049180.49740626
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49343124
131Toxoplasmosis_Homo sapiens_hsa051450.48797544
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48190128
133Synaptic vesicle cycle_Homo sapiens_hsa047210.46656391
134Pentose phosphate pathway_Homo sapiens_hsa000300.45986611
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45408063

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